非裔美国成年人神经元源性细胞外囊泡的性别特异性线粒体DNA变化：HIV感染和吸烟的影响

IF 1.9 4区医学 Q3 NEUROSCIENCES

Journal of NeuroVirology Pub Date : 2025-08-01 Epub Date: 2025-07-25 DOI:10.1007/s13365-025-01272-9

Vladimir Berthaud, Tarik Smith, Venkateswara R Amara, Derek Wilus, Franklin J Nouvet, Waldemar Popik

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引用次数: 0

摘要

细胞外囊泡（EVs）中的线粒体DNA （mtDNA）可能追踪hiv相关的神经元损伤。我们测量了48名非裔美国成年人神经元源性电动汽车（nev）和总血浆电动汽车的mtDNA拷贝数，这些成年人按性别、艾滋病毒感染状况和吸烟情况分层。NEV-mtDNA组间差异(p

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Sex-specific mitochondrial DNA changes in neuron-derived extracellular vesicles of African American adults: impact of HIV infection and smoking.

Mitochondrial DNA (mtDNA) in extracellular vesicles (EVs) may track HIV-related neuronal injury. We measured mtDNA copy number in neuron-derived EVs (NEVs) and total plasma EVs from 48 African American adults stratified by sex, HIV status, and smoking. NEV-mtDNA differed by group (p < 0.05): men with HIV showed the highest levels, markedly exceeding HIV-negative men and all women, while smoking raised NEV-mtDNA only in men. Plasma EV-mtDNA paralleled NEVs but was ~ 100-fold higher, reflecting systemic release. These sex-specific increases implicate HIV as a stronger mitochondrial stressor in men and support NEV-mtDNA as a convenient biomarker of neuro-mitochondrial dysfunction.

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来源期刊

Journal of NeuroVirology 医学-病毒学

CiteScore

6.60

自引率

3.10%

发文量

审稿时长

6-12 weeks

期刊介绍： The Journal of NeuroVirology (JNV) provides a unique platform for the publication of high-quality basic science and clinical studies on the molecular biology and pathogenesis of viral infections of the nervous system, and for reporting on the development of novel therapeutic strategies using neurotropic viral vectors. The Journal also emphasizes publication of non-viral infections that affect the central nervous system. The Journal publishes original research articles, reviews, case reports, coverage of various scientific meetings, along with supplements and special issues on selected subjects. The Journal is currently accepting submissions of original work from the following basic and clinical research areas: Aging & Neurodegeneration, Apoptosis, CNS Signal Transduction, Emerging CNS Infections, Molecular Virology, Neural-Immune Interaction, Novel Diagnostics, Novel Therapeutics, Stem Cell Biology, Transmissable Encephalopathies/Prion, Vaccine Development, Viral Genomics, Viral Neurooncology, Viral Neurochemistry, Viral Neuroimmunology, Viral Neuropharmacology.