疱疹病毒引发痴呆和自身免疫性疾病。

IF 1.9 4区 医学 Q3 NEUROSCIENCES
Journal of NeuroVirology Pub Date : 2025-08-01 Epub Date: 2025-07-07 DOI:10.1007/s13365-025-01265-8
Kevin Roe
{"title":"疱疹病毒引发痴呆和自身免疫性疾病。","authors":"Kevin Roe","doi":"10.1007/s13365-025-01265-8","DOIUrl":null,"url":null,"abstract":"<p><p>Several viral, bacterial, fungal, and protozoan parasite pathogens are capable of causing either active and/or latent chronic infections, particularly if they are highly immuno-evasive. The nine human herpesviruses are among the most evasive pathogens. They can remain latent for decades, but can periodically reactivate into active chronic infections after various triggers: medical treatments causing intentional or unintentional immune system suppression, other pathogen infections, malnutrition, stress, or unusual host cell signaling. Various neurological disorders including dementias and severe autoimmune diseases have been linked to highly prevalent human herpesvirus infections including herpes simplex type 1 and 2, varicella-zoster virus, Epstein-Barr virus, human cytomegalovirus, and herpesviruses 6A, 6B, 7 and 8. For example, dementias including Alzheimer's disease have been extensively linked to herpes simplex type 1 and 2, and herpesvirus 6A and 7, but other herpesviruses may be indirectly involved in dementias. For instance, recent evidence strongly suggests dementias can result from reactivated varicella-zoster herpes virus infections, whereas effective vaccinations against varicella-zoster herpes virus reactivations to avoid shingles have also shown significant reductions in dementia probabilities for vaccinated individuals. This raises questions about how various herpesviruses can initiate or enable neurological diseases including dementias and autoimmune diseases, and how their infections and particularly their reactivations from latency can initiate these diseases.</p>","PeriodicalId":16665,"journal":{"name":"Journal of NeuroVirology","volume":" ","pages":"305-332"},"PeriodicalIF":1.9000,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Herpesvirus initiation of dementias and autoimmune diseases.\",\"authors\":\"Kevin Roe\",\"doi\":\"10.1007/s13365-025-01265-8\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Several viral, bacterial, fungal, and protozoan parasite pathogens are capable of causing either active and/or latent chronic infections, particularly if they are highly immuno-evasive. The nine human herpesviruses are among the most evasive pathogens. They can remain latent for decades, but can periodically reactivate into active chronic infections after various triggers: medical treatments causing intentional or unintentional immune system suppression, other pathogen infections, malnutrition, stress, or unusual host cell signaling. Various neurological disorders including dementias and severe autoimmune diseases have been linked to highly prevalent human herpesvirus infections including herpes simplex type 1 and 2, varicella-zoster virus, Epstein-Barr virus, human cytomegalovirus, and herpesviruses 6A, 6B, 7 and 8. For example, dementias including Alzheimer's disease have been extensively linked to herpes simplex type 1 and 2, and herpesvirus 6A and 7, but other herpesviruses may be indirectly involved in dementias. For instance, recent evidence strongly suggests dementias can result from reactivated varicella-zoster herpes virus infections, whereas effective vaccinations against varicella-zoster herpes virus reactivations to avoid shingles have also shown significant reductions in dementia probabilities for vaccinated individuals. This raises questions about how various herpesviruses can initiate or enable neurological diseases including dementias and autoimmune diseases, and how their infections and particularly their reactivations from latency can initiate these diseases.</p>\",\"PeriodicalId\":16665,\"journal\":{\"name\":\"Journal of NeuroVirology\",\"volume\":\" \",\"pages\":\"305-332\"},\"PeriodicalIF\":1.9000,\"publicationDate\":\"2025-08-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of NeuroVirology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1007/s13365-025-01265-8\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/7/7 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q3\",\"JCRName\":\"NEUROSCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of NeuroVirology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s13365-025-01265-8","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/7/7 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"NEUROSCIENCES","Score":null,"Total":0}
引用次数: 0

摘要

几种病毒、细菌、真菌和原生动物寄生虫病原体能够引起活动性和/或潜伏性慢性感染,特别是如果它们是高度免疫逃避的。这九种人类疱疹病毒属于最难以捉摸的病原体。它们可以潜伏数十年,但可以在各种触发因素后周期性地重新激活为活跃的慢性感染:医学治疗引起有意或无意的免疫系统抑制,其他病原体感染,营养不良,压力或异常的宿主细胞信号。包括痴呆和严重自身免疫性疾病在内的各种神经系统疾病与高度流行的人类疱疹病毒感染有关,包括单纯疱疹1型和2型、水痘带状疱疹病毒、爱泼斯坦-巴尔病毒、人类巨细胞病毒和疱疹病毒6A、6B、7和8。例如,包括阿尔茨海默病在内的痴呆症与1型和2型单纯疱疹病毒以及疱疹病毒6A和7型广泛相关,但其他疱疹病毒可能间接与痴呆症有关。例如,最近的证据有力地表明,痴呆症可由水痘-带状疱疹病毒再激活感染引起,而针对水痘-带状疱疹病毒再激活以避免带状疱疹的有效疫苗接种也显示,接种疫苗的个体患痴呆症的可能性显著降低。这就提出了各种疱疹病毒如何引发或使神经系统疾病(包括痴呆和自身免疫性疾病)成为可能的问题,以及它们的感染,特别是它们在潜伏期的再激活如何引发这些疾病。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Herpesvirus initiation of dementias and autoimmune diseases.

Several viral, bacterial, fungal, and protozoan parasite pathogens are capable of causing either active and/or latent chronic infections, particularly if they are highly immuno-evasive. The nine human herpesviruses are among the most evasive pathogens. They can remain latent for decades, but can periodically reactivate into active chronic infections after various triggers: medical treatments causing intentional or unintentional immune system suppression, other pathogen infections, malnutrition, stress, or unusual host cell signaling. Various neurological disorders including dementias and severe autoimmune diseases have been linked to highly prevalent human herpesvirus infections including herpes simplex type 1 and 2, varicella-zoster virus, Epstein-Barr virus, human cytomegalovirus, and herpesviruses 6A, 6B, 7 and 8. For example, dementias including Alzheimer's disease have been extensively linked to herpes simplex type 1 and 2, and herpesvirus 6A and 7, but other herpesviruses may be indirectly involved in dementias. For instance, recent evidence strongly suggests dementias can result from reactivated varicella-zoster herpes virus infections, whereas effective vaccinations against varicella-zoster herpes virus reactivations to avoid shingles have also shown significant reductions in dementia probabilities for vaccinated individuals. This raises questions about how various herpesviruses can initiate or enable neurological diseases including dementias and autoimmune diseases, and how their infections and particularly their reactivations from latency can initiate these diseases.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Journal of NeuroVirology
Journal of NeuroVirology 医学-病毒学
CiteScore
6.60
自引率
3.10%
发文量
77
审稿时长
6-12 weeks
期刊介绍: The Journal of NeuroVirology (JNV) provides a unique platform for the publication of high-quality basic science and clinical studies on the molecular biology and pathogenesis of viral infections of the nervous system, and for reporting on the development of novel therapeutic strategies using neurotropic viral vectors. The Journal also emphasizes publication of non-viral infections that affect the central nervous system. The Journal publishes original research articles, reviews, case reports, coverage of various scientific meetings, along with supplements and special issues on selected subjects. The Journal is currently accepting submissions of original work from the following basic and clinical research areas: Aging & Neurodegeneration, Apoptosis, CNS Signal Transduction, Emerging CNS Infections, Molecular Virology, Neural-Immune Interaction, Novel Diagnostics, Novel Therapeutics, Stem Cell Biology, Transmissable Encephalopathies/Prion, Vaccine Development, Viral Genomics, Viral Neurooncology, Viral Neurochemistry, Viral Neuroimmunology, Viral Neuropharmacology.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信