Journal of Ophthalmic Inflammation and Infection最新文献

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Role of paranasal abnormalities and systemic inflammation on primary acquired nasolacrimal duct obstruction. 副鼻腔异常和全身炎症对原发性后天性鼻泪管阻塞的影响。
IF 2.9
Journal of Ophthalmic Inflammation and Infection Pub Date : 2024-08-14 DOI: 10.1186/s12348-024-00416-y
Neslihan Sevimli, Sevda Aydın Kurna, Muhammet Çakır, Sezen Akkaya
{"title":"Role of paranasal abnormalities and systemic inflammation on primary acquired nasolacrimal duct obstruction.","authors":"Neslihan Sevimli, Sevda Aydın Kurna, Muhammet Çakır, Sezen Akkaya","doi":"10.1186/s12348-024-00416-y","DOIUrl":"10.1186/s12348-024-00416-y","url":null,"abstract":"<p><strong>Background: </strong>To determine the paranasal changes and inflammatory markers that may cause primary acquired nasolacrimal duct obstruction (PANDO) and to determine their relationship with success rates on different types of surgeries.</p><p><strong>Main body: </strong>We retrospectively reviewed the blood sample and computed tomography (CT) results on 92 patients who underwent dacryocystorhinostomy (DCR) surgery for PANDO and 82 healthy controls. Age, gender, paranasal abnormalities, hemogram values, International Normalized Ratio (INR) values, type of surgery, and recurrence rate were recorded; systemic Immune-inflammation Index (SII), neutrophil-to-lymphocyte ratio (NLR), monocytes-to- lymphocyte ratio (MLR) and platelet-to-lymphocyte ratio (PLR) were calculated in both groups. In the case group, total white blood cells, monocytes, and INR values were significantly lower (p < 0.05). Platelet, lymphocyte, neutrophil, PLR, MLR, NLR, and SII values did not differ significantly between the control and case groups (p > 0.05). There was no significant difference in the CT results between the groups (p > 0.05). No correlation was found between CT findings and inflammatory markers. Dacryocystitis (DC) was seen in 20% of patients and they were all in the case group. No correlation was found between recurrence rate and age, gender, type of surgery, CT findings, and blood results (p > 0.05). The recurrence rate was significantly higher in patients with bilateral PANDO and with DC (p < 0.05).</p><p><strong>Short conclusion: </strong>The incidence of PANDO may not be directly related to paranasal abnormalities and systemic inflammation. Low INR values may cause obstruction in the nasolacrimal duct. Age, gender, type of surgery, CT findings, and inflammation level do not affect the success of the surgery.</p>","PeriodicalId":16600,"journal":{"name":"Journal of Ophthalmic Inflammation and Infection","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2024-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11324618/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141982567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Utility of pan-bacterial and pan-fungal PCR in endophthalmitis: case report and review of the literature. 泛细菌和泛真菌 PCR 在眼底病中的应用:病例报告和文献综述。
IF 2.9
Journal of Ophthalmic Inflammation and Infection Pub Date : 2024-08-01 DOI: 10.1186/s12348-024-00419-9
Carson W Ercanbrack, Dania A Rahal, Muhammad Z Chauhan, Sayena Jabbehdari, Sami H Uwaydat
{"title":"Utility of pan-bacterial and pan-fungal PCR in endophthalmitis: case report and review of the literature.","authors":"Carson W Ercanbrack, Dania A Rahal, Muhammad Z Chauhan, Sayena Jabbehdari, Sami H Uwaydat","doi":"10.1186/s12348-024-00419-9","DOIUrl":"10.1186/s12348-024-00419-9","url":null,"abstract":"<p><strong>Background: </strong>Endophthalmitis is a clinical diagnosis but identification of the disease-causing agent or agents allows for a more tailored treatment. This is routinely done through intraocular fluid cultures and staining. However, culture-negative endophthalmitis is a relatively common occurrence, and a causative organism cannot be identified. Thus, further diagnostic testing, such as pan-bacterial and pan-fungal polymerase chain reactions (PCRs), may be required. BODY: There are now newer, other testing modalities, specifically pan-bacterial and pan-fungal PCRs, that may allow ophthalmologists to isolate a causative agent when quantitative PCRs and cultures remain negative. We present a case report in which pan-fungal PCR was the only test, amongst quantitative PCRs, cultures, and biopsies, that was able to identify a pathogen in endophthalmitis. Pan-PCR has unique advantages over quantitative PCR in that it does not have a propensity for false-positive results due to contamination. Conversely, pan-PCR has drawbacks, including its inability to detect viruses and parasites and its increased turnaround time and cost. Based on two large retrospective studies, pan-PCR was determined not to be recommended in routine cases of systemic infection as it does not typically add value to the diagnostic workup and does not change the treatment course in most cases. However, in cases like the one presented, pan-bacterial and pan-fungal PCRs may be considered if empiric treatment fails or if the infective organism cannot be isolated. If pan-PCR remains negative or endophthalmitis continues to persist, an even newer form of testing, next-generation sequencing, may aid in the diagnostic workup of culture-negative endophthalmitis.</p><p><strong>Conclusion: </strong>Pan-bacterial and pan-fungal PCR testing is a relatively new diagnostic tool with unique advantages and drawbacks compared to traditional culturing and PCR methods. Similar to the tests' use in non-ophthalmic systemic infections, pan-bacterial and pan-fungal PCRs are unlikely to become the initial diagnosis test and completely replace culture methods. However, they can provide useful diagnostic information if an infectious agent is unable to be identified with traditional methods or if empiric treatment of endophthalmitis continues to fail.</p>","PeriodicalId":16600,"journal":{"name":"Journal of Ophthalmic Inflammation and Infection","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11294505/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141860104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical characteristics, predisposing factors, and management of moraxella keratitis in a tertiary eye hospital. 一家三级眼科医院莫拉菌角膜炎的临床特征、诱发因素和处理方法。
IF 2.9
Journal of Ophthalmic Inflammation and Infection Pub Date : 2024-07-30 DOI: 10.1186/s12348-024-00417-x
Mohammad Soleimani, Sadra Jalali Najafabadi, Alireza Razavi, Seyed Ali Tabatabaei, Saeed Mirmoosavi, Hassan Asadigandomani
{"title":"Clinical characteristics, predisposing factors, and management of moraxella keratitis in a tertiary eye hospital.","authors":"Mohammad Soleimani, Sadra Jalali Najafabadi, Alireza Razavi, Seyed Ali Tabatabaei, Saeed Mirmoosavi, Hassan Asadigandomani","doi":"10.1186/s12348-024-00417-x","DOIUrl":"10.1186/s12348-024-00417-x","url":null,"abstract":"<p><strong>Purpose: </strong>The Moraxella species is a very uncommon pathogen that leads to microbial keratitis (MK). This study aimed to evaluate the clinical features, predisposing factors, and outcomes of Moraxella keratitis in patients of a tertiary eye hospital.</p><p><strong>Methods: </strong>This retrospective study was conducted from 2015 to 2022, on patients who were admitted with the diagnosis of Moraxella keratitis confirmed by positive culture in a referral eye hospital. Demographics, predisposing factors, best-corrected visual acuity (BCVA), and prognosis were assessed.</p><p><strong>Results: </strong>A total of 106 individuals diagnosed with Moraxella keratitis, were analyzed. The mean age was 54.42 ± 19.43 years. The mean baseline BCVA of the patients was 2.28 ± 0.6 LogMAR, while this amount reached 1.49 ± 0.81 in the 6-month follow-up (P-value = 0.02). The mean BCVA in the six-month follow-up of the patients who needed surgical interventions was significantly lower than the patients who received only medical treatment (2.15 ± 0.65 vs. 1.29 ± 0.75 LogMAR, P-value = 0.02). Patients with diabetes and those without diabetes did not substantially vary in the prevalence of corneal perforation (P-value = 0.515). Three predisposing factors including corneal perforation (odds ratio = 19.27, P-value = 0.001), hypertension (HTN) (odds ratio = 3.62, P-value = 0.03), and older age (odds ratio = 1.03, P-value = 0.008) were significantly associated with more need for surgical interventions.</p><p><strong>Conclusion: </strong>In this cohort, poor prognosis necessitating surgical interventions in Moraxella keratitis was found to be associated with corneal perforation, HTN, and older age.</p>","PeriodicalId":16600,"journal":{"name":"Journal of Ophthalmic Inflammation and Infection","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2024-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11289192/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141855798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Management of Uveitis Patients on Anti-TNF Agents Who Develop Demyelinating Disease - A Case Series. 使用抗肿瘤坏死因子药物的葡萄膜炎患者出现脱髓鞘疾病时的管理--一个病例系列。
IF 2.9
Journal of Ophthalmic Inflammation and Infection Pub Date : 2024-07-30 DOI: 10.1186/s12348-024-00403-3
Abel Hamdan, Sumit Sharma, Kimberly Baynes, Rula A Hajj Ali, Careen Y Lowder, Sunil K Srivastava
{"title":"Management of Uveitis Patients on Anti-TNF Agents Who Develop Demyelinating Disease - A Case Series.","authors":"Abel Hamdan, Sumit Sharma, Kimberly Baynes, Rula A Hajj Ali, Careen Y Lowder, Sunil K Srivastava","doi":"10.1186/s12348-024-00403-3","DOIUrl":"10.1186/s12348-024-00403-3","url":null,"abstract":"<p><strong>Background/aims: </strong>Anti-tumor necrosis factor (Anti-TNF) agents have proven beneficial for the treatment of chronic non-infectious uveitis, yet rare neurological complications and demyelinating disease can occur with their use. Management of uveitis and neurological disease after developing these rare complications is not well understood. We sought to identify these specific cases and their outcomes through a retrospective observational case series.</p><p><strong>Methods: </strong>Electronic Medical Record (EMR) chart review of 394 non-infectious uveitis patients on anti-TNF therapy focused on identifying patients seen by uveitis specialists at a single institution who were on anti-TNF therapy and had developed neurological symptoms. Cases were reviewed for subsequent management and outcomes of both their neurologic and ocular inflammatory disease.</p><p><strong>Results: </strong>Five (5) patients were included following complaints of neurological symptoms while on anti-TNF therapy. Subsequent demyelinating diagnosis, acute treatment, and long-term course were described. All five patients continue to be inactive at around three years of anti-TNF discontinuation.</p><p><strong>Conclusion: </strong>Unidentified rare neurological symptoms and demyelinating disease associated with the use of anti-TNF agents can be detrimental to patient treatment outcomes. Emphasis is given on possible avoidance and early identification of exacerbating underlying disease through a detailed neurologic history and use of imaging when suspicion is high. Patients may have no evidence of higher neurological risk prior to starting an anti-TNF treatment. Discontinuation of an anti-TNF agent and subsequent control of disease is possible with alternative immunosuppressive treatments.</p>","PeriodicalId":16600,"journal":{"name":"Journal of Ophthalmic Inflammation and Infection","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2024-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11289187/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141792704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Paediatric Uveitis - the uniqueness in clinical presentation and the efficacy of biologics treatment. 小儿葡萄膜炎--临床表现的独特性和生物制剂治疗的疗效。
IF 2.9
Journal of Ophthalmic Inflammation and Infection Pub Date : 2024-07-17 DOI: 10.1186/s12348-024-00415-z
Mei Kwan Yiu, Mary Ho, Assunta C H Ho, Winnie K Y Chan, Wing Yung, Wilson W K Yip, Alvin L Young
{"title":"Paediatric Uveitis - the uniqueness in clinical presentation and the efficacy of biologics treatment.","authors":"Mei Kwan Yiu, Mary Ho, Assunta C H Ho, Winnie K Y Chan, Wing Yung, Wilson W K Yip, Alvin L Young","doi":"10.1186/s12348-024-00415-z","DOIUrl":"10.1186/s12348-024-00415-z","url":null,"abstract":"<p><strong>Aims: </strong>To evaluate unique clinical characteristics of paediatric uveitis in our locality and treatment outcomes especially the efficacy of biologics.</p><p><strong>Methods: </strong>This was a retrospective cohort.</p><p><strong>Results: </strong>37 paediatric uveitis cases involving 67 eyes were included. Male-to-female ratio was 1:1.3. Mean age of uveitis onset was 11 ± 3.7 (4-18). 81.1% cases suffered from bilateral uveitis. 75.7% cases were chronic uveitis. Nearly half of the cases (40.5%) presented with anterior uveitis. The predominant diagnosis of uveitis in our cohort was idiopathic. Unlike studies from other populations, the associated systemic conditions in this mostly Chinese cohort were Behçet's disease (8.1%), tubulointerstitial nephritis and uveitis (8.1%) and HLA-B27 associated uveitis (8.1%). Steroid response was a common phenomenon, observed in 40.5% of cases. The most common complication was posterior synechiae (45.9%), followed by cataract (37.8%), glaucoma (27.0%), band keratopathy (18.9%) and macular oedema (13.5%). 3/37 patients encountered either first attack of uveitis or flare after receiving COVID-19 vaccine. 54.1% of patients required systemic steroid for disease control. The majority required steroid sparing immunotherapy, including Methotrexate (43.2%), Mycophenolate Mofetil (24.3%), Cyclosporine A (8.1%), Azathioprine (5.4%) and Tacrolimus (2.7%). Resistant cases required biologics including tumour necrosis factor alpha inhibitors (Adalimumab 32.4%, Infliximab 2.7%) and interleukin-6 inhibitors (Tocilizumab 2.7%).</p><p><strong>Conclusions: </strong>Clinical presentation of the local paediatric uveitis differs from previously described features in Caucasian and other populations. According to our experience as a tertiary eye centre, Behçet's disease, tubulointerstitial nephritis and uveitis and HLA-B27 associated uveitis were more often encountered than Juvenile Idiopathic Arthritis associated uveitis. Our report evaluated the efficacy of immunomodulatory therapy and biologics in controlling uveitis and reducing ocular complications.</p>","PeriodicalId":16600,"journal":{"name":"Journal of Ophthalmic Inflammation and Infection","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2024-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11254883/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141627003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Infectious keratitis in pediatric population aged less than two years: a tertiary eye institute experience. 两岁以下儿童感染性角膜炎:一家三级眼科研究所的经验。
IF 2.9
Journal of Ophthalmic Inflammation and Infection Pub Date : 2024-07-15 DOI: 10.1186/s12348-024-00414-0
Mohammad Soleimani, Seyed Mahbod Baharnoori, Sadegh Ghafarian, Mehrnaz Atighehchian, Kasra Cheraqpour, Seyed Ali Tabatabaei, Hamidreza Ghanbari, Mahdi Soleimanzadeh, Faezeh Moghimpour Bijani, Solmaz Almasi, Haniyeh Zeidabadinejad, Ali Davarpanah, Marzieh Sajedi, Bahram Bohrani Sefidan, Samer Habeel, Ahmad Masoumi, Mohammad Hossein Zamani, Ali R Djalilian
{"title":"Infectious keratitis in pediatric population aged less than two years: a tertiary eye institute experience.","authors":"Mohammad Soleimani, Seyed Mahbod Baharnoori, Sadegh Ghafarian, Mehrnaz Atighehchian, Kasra Cheraqpour, Seyed Ali Tabatabaei, Hamidreza Ghanbari, Mahdi Soleimanzadeh, Faezeh Moghimpour Bijani, Solmaz Almasi, Haniyeh Zeidabadinejad, Ali Davarpanah, Marzieh Sajedi, Bahram Bohrani Sefidan, Samer Habeel, Ahmad Masoumi, Mohammad Hossein Zamani, Ali R Djalilian","doi":"10.1186/s12348-024-00414-0","DOIUrl":"10.1186/s12348-024-00414-0","url":null,"abstract":"<p><strong>Background: </strong>Infectious keratitis is a serious ocular condition, which can lead to corneal scarring, vision loss, and even blindness. Pediatric infectious keratitis accounts for about 13% of all cases, although there is a lack of comprehensive data regarding keratitis in less than two years of age population group. This study was aimed to determine predisposing factors, clinical characteristics, microbial profile, and management of infectious keratitis in a population of children aged less than two years.</p><p><strong>Materials and methods: </strong>A retrospective study was carried out in a tertiary eye institute over a period of 18 years from July 2005 to December 2022. Collected data was analyzed for demographics, predisposing factors, clinical features, and treatment methods.</p><p><strong>Results: </strong>Fifty-seven cases of keratitis were identified. Age of the patients ranged from 1 to 24 months (Median: 6, interquartile range: 2-10). Thirty cases were male (52.6%). Predisposing factors were identified in 39 cases (68.4%): consisting of prior ocular trauma (n = 15), previous intraocular surgery (n = 11), ocular surface disease (n = 10), nasolacrimal duct obstruction (n = 4), prematurity (n = 3), developmental delay (n = 2), TORCH infection (n = 1), and contact lens (n = 1). Corneal thinning was observed in 29 eyes (50.9%), which progressed to perforation in 13 eyes (22.8%). Three patients developed endophthalmitis (95% CI, 1.5-13.4%). Most eyes had negative smear (60.4%) and culture (59.6%) results. Pseudomonas aeruginosa was the most common microorganism (11 of 21). Candida albicans was isolated in one case. In vitro susceptibility results showed good coverage of the combined ceftazidime and vancomycin regimen (100%). Surgical procedures were carried out in 35 eyes (61.4%) and 15 eyes required tectonic procedures (26.3%).</p><p><strong>Conclusion: </strong>Despite good coverage of medical treatment over cultured isolates, surgical tectonic intervention was required in nearly a quarter of cases to resolve the corneal infection. This finding indicates the necessity of prompt patient referring, corneal sampling and initiation of the treatment.</p>","PeriodicalId":16600,"journal":{"name":"Journal of Ophthalmic Inflammation and Infection","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2024-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11250718/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141616638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Human ocular dirofilariasis in Poland. 波兰的人类眼丝虫病。
IF 2.9
Journal of Ophthalmic Inflammation and Infection Pub Date : 2024-07-10 DOI: 10.1186/s12348-024-00401-5
Piotr J Gaca, Rafal Nowak, Robert Rejdak, Magdalena Rejdak, Maja Nowak, Beata Flis, Mohammad Javed Ali
{"title":"Human ocular dirofilariasis in Poland.","authors":"Piotr J Gaca, Rafal Nowak, Robert Rejdak, Magdalena Rejdak, Maja Nowak, Beata Flis, Mohammad Javed Ali","doi":"10.1186/s12348-024-00401-5","DOIUrl":"10.1186/s12348-024-00401-5","url":null,"abstract":"","PeriodicalId":16600,"journal":{"name":"Journal of Ophthalmic Inflammation and Infection","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2024-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11236825/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141563569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Retinal vasculitis in HLA-A29 birdshot retinochoroiditis, particularities and imaging narrative of an under-estimated and diagnostic component of the disease. HLA-A29 鸟枪状视网膜脉络膜炎中的视网膜血管炎,一种被低估的诊断性疾病的特殊性和影像学描述。
IF 2.9
Journal of Ophthalmic Inflammation and Infection Pub Date : 2024-07-09 DOI: 10.1186/s12348-024-00406-0
Jérôme Galand, Ioannis Papasavvas, Carl P Herbort
{"title":"Retinal vasculitis in HLA-A29 birdshot retinochoroiditis, particularities and imaging narrative of an under-estimated and diagnostic component of the disease.","authors":"Jérôme Galand, Ioannis Papasavvas, Carl P Herbort","doi":"10.1186/s12348-024-00406-0","DOIUrl":"10.1186/s12348-024-00406-0","url":null,"abstract":"<p><strong>Background: </strong>HLA-A29 birdshot retinochoroiditis (BRC) is a primary stromal choroiditis (PSC), the hallmark being the choroidal rice-shaped hypopigmented fundus lesions (\"birdshot lesions\"). BRC is characterised by dual independent retinal vasculitis and choroiditis, the former often preceding manifest choroidal lesions. The purpose of this study was to analyse the type and severity of retinal vasculitis and determine whether it represented a diagnostic contribution. Medical records of patients with the diagnosis of BRC examined in the uveitis clinic of the Centre for Ophthalmic Specialised care (COS) in Lausanne from 1994 to 2020, were retrospectively reviewed. All patients had a complete ophthalmic examination, including visual field testing, optical coherence tomography (OCT), and fluorescein (FA) and indocyanine green (ICGA) angiography. Key retinal angiographic features were assessed. The study also established the angiographic score for retinal (FA) compared to choroidal involvement (ICGA). Among the 2102 newly diagnosed patients, 33 (1.57%) were diagnosed as BRC. Of the 21 patients with sufficient data included, all exhibited bilateral retinal vasculitis, of which 5 (24%) had no \"birdshot lesions\" at presentation with ICGA however always showing choroidal involvement. FA characteristics included (1) profuse retinal exudation in 17/21 cases (81%), (2) macular oedema in 17 patients (81%) with foveolar sparing for 14 of them (82%), (3) thick sheathing/staining of large posterior pole vessels in 13 patients (62%) and (4) profuse disc hyperfluorescence in all 21 patients. (5) A specific feature was the so-called pseudo arterio-venous circulatory delay in 17/21 cases (81%). The FA angiographic score at presentation was 14.49 ± 5.1 equivalent to the ICGA angiographic score of 14.29 ± 3.6, and higher than in other chorioretinitis entities. Both angiographic scores decreased similarly after treatment with a slower response of the retinal involvement.</p><p><strong>Conclusions: </strong>Retinal vasculitis in BRC is often very pronounced and presents distinct angiographic features that help substantially in the diagnosis and understanding of the disease course. Retinal vasculitis can present initially as an isolated feature in absence of the characteristic \"birdshot lesions\". The presence of all or some of the specific FA features strongly orient towards BRC to seek confirmation by ICGA and the search for the HLA-A29 antigen.</p>","PeriodicalId":16600,"journal":{"name":"Journal of Ophthalmic Inflammation and Infection","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2024-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11233484/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141558977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Corneal ulceration following periocular scorpion sting: a case report. 眼周被蝎子蛰伤后角膜溃疡:病例报告。
IF 2.9
Journal of Ophthalmic Inflammation and Infection Pub Date : 2024-06-25 DOI: 10.1186/s12348-024-00411-3
Mohammad Shiravani, Mahmood Nejabat, Alireza Attar
{"title":"Corneal ulceration following periocular scorpion sting: a case report.","authors":"Mohammad Shiravani, Mahmood Nejabat, Alireza Attar","doi":"10.1186/s12348-024-00411-3","DOIUrl":"10.1186/s12348-024-00411-3","url":null,"abstract":"<p><strong>Background: </strong>Scorpion envenomation, a prevalent medical emergency in rural areas, demands immediate attention due to its potential severity. While ocular manifestations are uncommon, they can lead to significant complications such as corneal ulceration. We present a unique case of corneal ulceration subsequent to a yellow scorpion (Hemiscorpius lepturus) sting near the eye, a scenario not previously documented.</p><p><strong>Case presentation: </strong>A 34-year-old male sought medical care following a scorpion sting despite prior anti-venom treatment. Clinical examination revealed pronounced ocular inflammation, corneal stromal melting, and anterior chamber inflammation, with microbiological confirmation of Pseudomonas spp infection. Treatment comprised fortified ceftazidime and vancomycin eye drops, alongside topical corticosteroids, leading to visual and corneal healing.</p><p><strong>Conclusion: </strong>This case highlights the urgency of addressing scorpion envenomation and its potential for severe ocular complications, including corneal ulceration. Prompt diagnosis and targeted therapy with antibiotics and corticosteroids are crucial for favorable outcomes. A comprehensive understanding and timely intervention in scorpion sting-induced ocular manifestations are essential for optimal patient management and outcomes in such cases.</p>","PeriodicalId":16600,"journal":{"name":"Journal of Ophthalmic Inflammation and Infection","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2024-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11199440/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141452704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The roles of IRF8 in nonspecific orbital inflammation: an integrated analysis by bioinformatics and machine learning. IRF8在非特异性眼眶炎症中的作用:生物信息学和机器学习的综合分析。
IF 2.9
Journal of Ophthalmic Inflammation and Infection Pub Date : 2024-06-20 DOI: 10.1186/s12348-024-00410-4
Zixuan Wu, Jinfeng Xu, Yi Hu, Xin Peng, Zheyuan Zhang, Xiaolei Yao, Qinghua Peng
{"title":"The roles of IRF8 in nonspecific orbital inflammation: an integrated analysis by bioinformatics and machine learning.","authors":"Zixuan Wu, Jinfeng Xu, Yi Hu, Xin Peng, Zheyuan Zhang, Xiaolei Yao, Qinghua Peng","doi":"10.1186/s12348-024-00410-4","DOIUrl":"10.1186/s12348-024-00410-4","url":null,"abstract":"<p><strong>Background: </strong>Nonspecific Orbital Inflammation (NSOI) represents a persistent and idiopathic proliferative inflammatory disorder, characterized by polymorphous lymphoid infiltration within the orbit. The transcription factor Interferon Regulatory Factor 8 (IRF8), integral to the IRF protein family, was initially identified as a pivotal element for the commitment and differentiation of myeloid cell lineage. Serving as a central regulator of innate immune receptor signaling, IRF8 orchestrates a myriad of functions in hematopoietic cell development. However, the intricate mechanisms underlying IRF8 production remain to be elucidated, and its potential role as a biomarker for NSOI is yet to be resolved.</p><p><strong>Methods: </strong>IRF8 was extracted from the intersection analysis of common DEGs of GSE58331 and GSE105149 from the GEO and immune- related gene lists in the ImmPort database using The Lasso regression and SVM-RFE analysis. We performed GSEA and GSVA with gene sets coexpressed with IRF8, and observed that gene sets positively related to IRF8 were enriched in immune-related pathways. To further explore the correlation between IRF8 and immune-related biological process, the CIBERSORT algorithm and ESTIMATE method were employed to evaluate TME characteristics of each sample and confirmed that high IRF8 expression might give rise to high immune cell infiltration. Finally, the GSE58331 was utilized to confirm the levels of expression of IRF8.</p><p><strong>Results: </strong>Among the 314 differentially expressed genes (DEGs), some DEGs were found to be significantly different. With LASSO and SVM-RFE algorithms, we obtained 15 hub genes. For biological function analysis in IRF8, leukocyte mediated immunity, leukocyte cell-cell adhesion, negative regulation of immune system process were emphasized. B cells naive, Macrophages M0, Macrophages M1, T cells CD4 memory activated, T cells CD4 memory resting, T cells CD4 naive, and T cells gamma delta were shown to be positively associated with IRF8. While, Mast cells resting, Monocytes, NK cells activated, Plasma cells, T cells CD8, and T cells regulatory (Tregs) were shown to be negatively linked with IRF8. The diagnostic ability of the IRF8 in differentiating NSOI exhibited a good value.</p><p><strong>Conclusions: </strong>This study discovered IRF8 that are linked to NSOI. IRF8 shed light on potential new biomarkers for NSOI and tracking its progression.</p>","PeriodicalId":16600,"journal":{"name":"Journal of Ophthalmic Inflammation and Infection","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2024-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11190126/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141427019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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