Journal of Ophthalmic Inflammation and Infection最新文献

{"title":"Recurrent strokes as the sole manifestation of antineutrophil cytoplasmic antibody associated vasculitis in a patientwith panuveitis: a case report.","authors":"Hadeel Seraj, Hanan A Alshalan, Reham Alemam, Mohammed A Omair","doi":"10.1186/s12348-025-00454-0","DOIUrl":"10.1186/s12348-025-00454-0","url":null,"abstract":"<p><p>Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitides (AAV) are a heterogeneous group of rare, autoimmune conditions characterized by widespread, multisystemic inflammation of small to medium-sized blood vessels. We present a case report of a 46-year-old male with a history of prior ischemic strokes and recurrent bilateral non-granulomatous panuveitis associated with a strongly positive cytoplasmic anti-neutrophil cytoplasmic antibody (c-ANCA) titer. Initial treatment with steroids, methotrexate, and rituximab were ineffective, but the condition responded moderately to cyclophosphamide. This case underscores the importance of considering AAV in patients with unexplained ocular inflammation and highlights the role of c-ANCA testing in diagnosing and managing such cases, even in the absence of classic systemic symptoms.</p>","PeriodicalId":16600,"journal":{"name":"Journal of Ophthalmic Inflammation and Infection","volume":"15 1","pages":"10"},"PeriodicalIF":2.9,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11842660/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143468362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biopsy-proven ocular sarcoidosis manifesting as Weerfordt-Waldenström syndrome presenting with bilateral anterior granulomatous uveitis, multifocal retinal granulomas, and multifocal choroiditis.","authors":"Zina Berbich, Imen Ksiaa, Yassir Imani, Sanaa Ahbeddou, Hicham Harmouche, Omar Berbich, Moncef Khairallah","doi":"10.1186/s12348-025-00464-y","DOIUrl":"10.1186/s12348-025-00464-y","url":null,"abstract":"","PeriodicalId":16600,"journal":{"name":"Journal of Ophthalmic Inflammation and Infection","volume":"15 1","pages":"9"},"PeriodicalIF":2.9,"publicationDate":"2025-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11830646/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143425536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnosis of microbial keratitis using smartphone-captured images; a deep-learning model.","authors":"Mohammad Soleimani, Albert Y Cheung, Amir Rahdar, Artak Kirakosyan, Nicholas Tomaras, Isaiah Lee, Margarita De Alba, Mehdi Aminizade, Kosar Esmaili, Natalia Quiroz-Casian, Mohamad Javad Ahmadi, Siamak Yousefi, Kasra Cheraqpour","doi":"10.1186/s12348-025-00465-x","DOIUrl":"10.1186/s12348-025-00465-x","url":null,"abstract":"<p><strong>Background: </strong>Microbial keratitis (MK) poses a substantial threat to vision and is the leading cause of corneal blindness. The outcome of MK is heavily reliant on immediate treatment following an accurate diagnosis. The current diagnostics are often hindered by the difficulties faced in low and middle-income countries where there may be a lack of access to ophthalmic units with clinical experts and standardized investigating equipment. Hence, it is crucial to develop new and expeditious diagnostic approaches. This study explores the application of deep learning (DL) in diagnosing and differentiating subtypes of MK using smartphone-captured images.</p><p><strong>Materials and methods: </strong>The dataset comprised 889 cases of bacterial keratitis (BK), fungal keratitis (FK), and acanthamoeba keratitis (AK) collected from 2020 to 2023. A convolutional neural network-based model was developed and trained for classification.</p><p><strong>Results: </strong>The study demonstrates the model's overall classification accuracy of 83.8%, with specific accuracies for AK, BK, and FK at 81.2%, 82.3%, and 86.6%, respectively, with an AUC of 0.92 for the ROC curves.</p><p><strong>Conclusion: </strong>The model exhibits practicality, especially with the ease of image acquisition using smartphones, making it applicable in diverse settings.</p>","PeriodicalId":16600,"journal":{"name":"Journal of Ophthalmic Inflammation and Infection","volume":"15 1","pages":"8"},"PeriodicalIF":2.9,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11825435/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143408842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retinitis linked to human herpesvirus type 6: a case study in a splenectomised patient.","authors":"Joana Santos-Oliveira, Ana Maria Cunha, Ana Filipa Moleiro, Margarida Ribeiro, Sónia Torres-Costa, Cláudia Oliveira-Ferreira, Ana Catarina Pedrosa, Joana Araújo, Luís Figueira, Marta Silva","doi":"10.1186/s12348-025-00460-2","DOIUrl":"10.1186/s12348-025-00460-2","url":null,"abstract":"<p><p>Human herpesvirus-6 (HHV-6) is a member of the HHV family and is a rare cause of infectious uveitis. We report a case of a splenectomised patient, hospitalised due to invasive pneumococcal disease, who was diagnosed with retinitis in the right eye, with good visual acuity (0.1 LogMAR). Given the presence of HHV-6 Polymerase chain reaction (PCR) in the cerebrospinal fluid and the serum and the coexistence of a severe central nervous system infection, the ophthalmological features were attributed to the HHV-6 infection. He was treated with topical corticosteroid eyedrops, cyclopentolate, and prednisolone acetate ointment and systemically with intravenous ganciclovir 5 mg/kg bid for 14 days and then oral valganciclovir 900 mg bid for 4 weeks. The diagnosis was promptly presumed, enabling the early initiation of appropriate treatment and contributing to the preservation of the good visual acuity initially observed.</p>","PeriodicalId":16600,"journal":{"name":"Journal of Ophthalmic Inflammation and Infection","volume":"15 1","pages":"7"},"PeriodicalIF":2.9,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11811316/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143382413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of macular retinal thickness in polyarteritis nodosa using spectral domain optical coherence tomography.","authors":"Che-Ning Yang, Chia-Ping Chen, Yi-Ting Hsieh","doi":"10.1186/s12348-025-00453-1","DOIUrl":"10.1186/s12348-025-00453-1","url":null,"abstract":"<p><strong>Purpose: </strong>To identify the macular retinal layer thickness changes in polyarteritis nodosa (PAN) patients without pathological findings appearing in color fundus photography (CFP), and to investigate the correlations with disease durations.</p><p><strong>Methods: </strong>A total of 24 PAN patients who had been for 3 years or more and underwent SD-OCT were recruited from the UK Biobank, with exclusions for diabetes, eye disease, or abnormal CFP findings. Only the right eyes were included, with each PAN patient paired one-to-one with a control matched for age, sex, and ethnicity. Paired t-tests or Wilcoxon Signed-Rank tests were used to assess the differences in thickness of different retinal layers between groups, followed by linear regression analysis to evaluate the correlations with disease durations.</p><p><strong>Results: </strong>PAN patients had significantly thinner retinal nerve fiber layer (RNFL) by 12.27% (mean ± standard deviation = 27.39 ± 8.94 μm for PAN patients and 31.22 ± 5.57 μm for controls, p = 0.048) and thinner outer plexiform and outer nuclear layers (OPL-ONL complex) by 10.67% (44.93 ± 6.59 μm for PAN patients and 50.31 ± 7.60 μm for controls, p = 0.032). Visual acuity and the whole macular thickness showed no statistical difference. The RNFL was thinned by 1.22 μm per year of disease progression (95% confidence interval: 0.12, 2.32, p = 0.042).</p><p><strong>Conclusions: </strong>PAN patients without visual impairments or abnormal CFP findings may exhibit significant thinning in RNFL and OPL-ONL complex. SD-OCT may serve as a useful tool for early screening of ophthalmic changes in PAN.</p>","PeriodicalId":16600,"journal":{"name":"Journal of Ophthalmic Inflammation and Infection","volume":"15 1","pages":"6"},"PeriodicalIF":2.9,"publicationDate":"2025-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11732801/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142978989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acute macular neuroretinopathy occurrence in a Behçet disease patient: a case report.","authors":"Ayman Mabchour, Moncef Ould Hamou, Simon Correa, François Willermain, Nacima Kisma","doi":"10.1186/s12348-025-00457-x","DOIUrl":"10.1186/s12348-025-00457-x","url":null,"abstract":"<p><strong>Purpose: </strong>To report the occurrence of AMN (Acute Macular Neuroretinopathy) in a Behçet Disease (BD) patient during an active systemic inflammatory relapse and to describe the SD-OCT features of this entity.</p><p><strong>Patients and methods: </strong>Retrospective observational case report of a patient who presented with an AMN during a BD associated ocular inflammation (Saint Pierre Hospital, Brussels, Belgium). Clinical record and imaging, including infrared reflectance image (IR) and spectral domain optical coherence tomography (SD-OCT), were analyzed.</p><p><strong>Results: </strong>A 25-year-old man presented with an acute right eye scotoma due to AMN in the setting of active systemic BD. Oral corticosteroid therapy and corticosteroid sparing agents (azathioprine) were prescribed. Close observation revealed progressive lesion regression.</p><p><strong>Conclusion: </strong>In conclusion, the association between AMN and BD may occur in the context of active systemic disease, though further studies are required to better establish this link. Vigilance appears warranted during inflammatory episodes in BD, as they might contribute to such manifestations. Clinicians could consider BD as a potential differential diagnosis in patients presenting with features suggestive of AMN, and neurological involvement may merit cerebral imaging to exclude other causes. Additionally, the management of posterior uveitis in BD, if present, may benefit from timely and targeted treatment. Further investigations are necessary to refine management strategies for AMN in patients with BD.</p>","PeriodicalId":16600,"journal":{"name":"Journal of Ophthalmic Inflammation and Infection","volume":"15 1","pages":"5"},"PeriodicalIF":2.9,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11729604/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142978986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Infectious keratitis following photorefractive keratectomy: a 13-year study at a tertiary center.","authors":"Alireza Attar, Hossein Jamali, Julio Ortega-Usobiaga, Golnoush Mahmoudinezhad, Dagny Zhu, Mohammad Mohammadi","doi":"10.1186/s12348-025-00452-2","DOIUrl":"10.1186/s12348-025-00452-2","url":null,"abstract":"<p><strong>Introduction: </strong>Infectious keratitis is a rare but devastating complication following photorefractive keratectomy (PRK) that may lead to visual impairment. This study assessed the clinical features, treatment strategies, and outcomes of post-PRK infectious keratitis.</p><p><strong>Methods: </strong>This retrospective study was conducted on patients with post-PRK infectious keratitis presenting to Khalili Hospital, Shiraz, Iran, from June 2011 to March 2024. The study was conducted in two stages: the first stage assessed the incidence of post-PRK infectious keratitis among patients who underwent PRK at our center, while the second stage included all patients with post-PRK infectious keratitis, regardless of where their PRK was performed. The following data were collected: demographics, post-surgery presentation time, risk factors, culture results, treatments, follow-up duration, complications, and corrected distance visual acuity (CDVA) at admission and the last follow-up.</p><p><strong>Results: </strong>Forty-two patients (42 eyes) with a mean age of 28.74 years (male-to-female ratio of 1.2:1) were included. Among 38,938 PRK procedures performed at our center, the incidence of keratitis was estimated to be 0.018% (7/38,938). The odds of keratitis during the COVID-19 pandemic were 7.05 times higher (95% CI: 1.58 to 31.52, p-value = 0.015) than outside this timeframe (February 2020 to August 2023). Gram-positive bacteria were the most commonly isolated pathogens in microbiological studies, accounting for 45.2% (19/42) of cases. Early-onset infections were primarily caused by Staphylococcus aureus (9/26, 34.6%), Staphylococcus epidermidis (4/26, 15.4%), and Pseudomonas aeruginosa (4/26, 15.4%), whereas all of the cases with fungi (4/4, 100% (and Acanthamoeba (3/3, 100%) infections caused late-onset infections. All patients received broad-spectrum antibiotic therapy, followed by adjusted treatment based on microbial results. Cases developing endophthalmitis and those not responding to treatment or having non-resolving corneal scars required further interventions, such as penetrating keratoplasty and deep vitrectomy. The mean follow-up duration was 40.81 months, and 97.6% (41/42) of cases experienced CDVA improvement at follow-up.</p><p><strong>Conclusion: </strong>This long-term study found a post-PRK keratitis rate of 0.018%, with gram-positive bacteria as the most common pathogens. Prompt management and regular follow-up assessments are essential for achieving satisfactory outcomes.</p>","PeriodicalId":16600,"journal":{"name":"Journal of Ophthalmic Inflammation and Infection","volume":"15 1","pages":"4"},"PeriodicalIF":2.9,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11723873/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142950355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Automated quantification of anterior chamber cells using swept-source anterior segment optical coherence tomography.","authors":"Shani Pillar, Shin Kadomoto, Keren Chen, Saitiel Sandoval Gonzalez, Nina Cherian, Joseph K Privratsky, Nicolette Zargari, Nicholas J Jackson, Giulia Corradetti, Judy L Chen, SriniVas R Sadda, Gary N Holland, Edmund Tsui","doi":"10.1186/s12348-025-00456-y","DOIUrl":"10.1186/s12348-025-00456-y","url":null,"abstract":"<p><strong>Purpose: </strong>To validate automated counts of presumed anterior chamber (AC) cells in eyes with histories of uveitis involving the anterior segment using swept-source (SS) anterior segment optical coherence tomography (AS-OCT) against manual counts and compare automated counts against Standardized Uveitis Nomenclature (SUN) criteria.</p><p><strong>Methods: </strong>Eyes were imaged with the ANTERION SS AS-OCT device (Heidelberg Engineering). A fully automated custom algorithm quantified the number of hyper-reflective foci (HRF) in line-scan images. Automated and manual counts were compared using interclass correlation (ICC) and Pearson correlation coefficient. Automated counts were compared to SUN grades using a mixed-effects linear regression model.</p><p><strong>Results: </strong>90 eyes (54 participants) were included; 67 eyes (41 participants) had histories of uveitis, while 23 eyes (13 healthy participants) served as controls. ICC comparing automated to manual counts was 0.99 and the Pearson correlation coefficient was 0.98. Eyes at each SUN grade with corresponding median HRF (interquartile range [IQR]) were: Grade 0, 42 eyes, 2 HRF (0,4); 0.5+, 10 eyes, 10 HRF (8,15); 1+, 9 eyes, 22 HRF (15,33); 2+, 3 eyes, 27 HRF; 3+, 2 eyes, 128 HRF; 4+, 1 eye, 474 HRF. For every 1-step increase in grade, automated count increased by 38 (p < 0.001) or 293% (Pearson correlation coefficient 0.80, p < 0.001). Automated counts differed significantly between clinically inactive eyes (2 HRF [0,4]) and controls (0 HRF [0,1], p = 0.02).</p><p><strong>Conclusions: </strong>Our algorithm accurately counts HRF when compared to manual counts, with strong correlation to SUN clinical grades. SS AS-OCT offers the advantage of imaging of the entire AC and may allow detection of subclinical inflammation in eyes that appear clinically inactive.</p>","PeriodicalId":16600,"journal":{"name":"Journal of Ophthalmic Inflammation and Infection","volume":"15 1","pages":"3"},"PeriodicalIF":2.9,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11717729/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142950352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical and bacteriological characteristics of Corynebacterium keratitis.","authors":"Hidenori Inoue, Koji Toriyama, Shinobu Murakami, Hitoshi Miyamoto, Wakako Ikegawa, Yuki Takezawa, Yuri Sakane, Yuko Hara, Atsushi Shiraishi","doi":"10.1186/s12348-025-00451-3","DOIUrl":"10.1186/s12348-025-00451-3","url":null,"abstract":"<p><strong>Purpose: </strong>Corynebacterium species are commensals of human skin and mucous membranes and are recognized as important pathogens in ocular infections. This study investigated the clinical characteristics of Corynebacterium keratitis.</p><p><strong>Methods: </strong>We retrospectively reviewed cases of bacterial keratitis in which Corynebacterium species were solely isolated from corneal scraping cultures collected at Ehime University Hospital between January 2010 and February 2024. The clinical findings of Corynebacterium keratitis were divided into two types: adherent and infiltrative, which are defined as adhesion to the corneal surface or stromal infiltration, respectively.</p><p><strong>Results: </strong>Of the 232 culture-positive cases of bacterial keratitis, 23 (9.9%) were positive for Corynebacterium species alone. The mean patient age was 60.1 ± 21.0 years, and the cohort included 12 males and 11 females. Adherent type was found in 13 patients (56.5%) and infiltrative type was observed in 10 patients (43.5%). Fluoroquinolone eye drops were used by 14 (60.9%) patients and steroid eye drops by 12 (52.2%). Corynebacterium macginleyi was the most commonly identified species (85.7%). 91% of Corynebacterium isolates were resistant to fluoroquinolones. All of C. macginleyi isolates were fluoroquinolone-resistant, and 93.3% of the isolates were highly resistant (minimal inhibitory concentrations > 32 µg/mL). All cases were treated with frequent antimicrobial eye drops, mainly cephalosporins, and the mean treatment duration was 21.6 days. Although no patient required therapeutic keratoplasty, five adherent types required multiple therapeutic debridements to physically remove the bacteria.</p><p><strong>Conclusions: </strong>Corynebacterium keratitis presented as adherent and infiltrative types of lesions. The main characteristics of the patient included the use of fluoroquinolone and steroid eye drops.</p>","PeriodicalId":16600,"journal":{"name":"Journal of Ophthalmic Inflammation and Infection","volume":"15 1","pages":"2"},"PeriodicalIF":2.9,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11711437/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142950353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Fluocinolone acetonide 0.2 µg/day intravitreal implant in non-infectious uveitis affecting the posterior segment: EU expert user panel consensus-based clinical recommendations.","authors":"Uwe Pleyer, Carlos Pavesio, Elisabetta Miserocchi, Carsten Heinz, Helen Devonport, Víctor Llorenç, Tomás Burke, Vanda Nogueira, Laurent Kodjikian, Bahram Bodaghi","doi":"10.1186/s12348-024-00450-w","DOIUrl":"10.1186/s12348-024-00450-w","url":null,"abstract":"","PeriodicalId":16600,"journal":{"name":"Journal of Ophthalmic Inflammation and Infection","volume":"15 1","pages":"1"},"PeriodicalIF":2.9,"publicationDate":"2025-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11711418/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142950354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}