Journal of Ophthalmic Inflammation and Infection最新文献

{"title":"Multizonal outer retinopathy and retinal pigment epitheliopathy (MORR) with a chronologically divergent presentation- a case report.","authors":"Blerta Lang, Karl Boden, Boris V Stanzel, Ulrich Prothmann, Peter Szurman","doi":"10.1186/s12348-025-00519-0","DOIUrl":"10.1186/s12348-025-00519-0","url":null,"abstract":"","PeriodicalId":16600,"journal":{"name":"Journal of Ophthalmic Inflammation and Infection","volume":"15 1","pages":"57"},"PeriodicalIF":2.3,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12283491/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144690572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Real-world treatment patterns for patients with non-infectious uveitis in Japan: a descriptive study using a large-scale claims database (J-CAT study).","authors":"Sentaro Kusuhara, Koh-Hei Sonoda, Toshikatsu Kaburaki, Tachie Fujita, Saki Katayama, Misako Makishima, Takao Nakamura, Mariko Nio, Takashi Omoto, Yukari Matsuo-Tezuka, Tomoki Yoshizaki, Kensuke Sasaki, Kairi Ri, Keiko Sato, Hiroshi Goto","doi":"10.1186/s12348-025-00514-5","DOIUrl":"10.1186/s12348-025-00514-5","url":null,"abstract":"<p><strong>Purpose: </strong>Non-infectious uveitis (NIU) can arise from various inflammatory disorders and can cause vision loss. Patients with mild NIU are typically treated with corticosteroid eye drops to reduce intraocular inflammation; however, other local/systemic treatments (corticosteroids, immunosuppressants, biologics) may be required for moderate-to-severe NIU, which may cause ocular complications. Here, we investigated real-world treatment patterns for NIU in Japan.</p><p><strong>Methods: </strong>Patients were selected from a large, Japanese insurance claims database using International Classification of Diseases, Tenth Revision codes; diagnosis of NIU was confirmed via ophthalmological examination (October 2016-October 2023). Sankey diagrams were used to describe treatment transitions. Post-treatment ocular complications, potentially related surgeries, and fundus findings associated with uveitis were determined.</p><p><strong>Results: </strong>The majority of patients (68.7%; 37,869/55,091) were treated with corticosteroid eye drops only for mild NIU; 19.0% (10,449/55,091) were given other treatments for moderate-to-severe NIU, mostly oral corticosteroids (7,473/10,449) and posterior sub-Tenon's corticosteroid injections (1,636/10,449). In patients treated with corticosteroids orally or via sub-Tenon's injections, common transitions were to corticosteroid eye drops or censor (end of treatment/dataset or insurance withdrawal). A higher incidence of treatment-related ocular complications and potentially related surgeries (including glaucoma) was observed during the first year of NIU treatment compared with subsequent years (for moderate-to-severe NIU, estimated incidence of prescription of glaucoma drugs was 106 per 1,000 person-years [at 1 year], 73 per 1,000 person-years [at 2 years], and 52 per 1,000 person-years [at 5 years]).</p><p><strong>Conclusion: </strong>Our comprehensive analysis of a large claims database included all prescribed medications and medical procedures (including local injections) for NIU treatment in Japan up to October 2023. Although corticosteroids are a mainstay of NIU treatment in Japan, we found that a number of treatments for moderate-to-severe NIU, other than corticosteroid eye drops, are frequently used in combination with or when switching from corticosteroid eye drops. These findings are of importance when assessing the treatment landscape and may help identify unmet clinical needs in patients with NIU.</p>","PeriodicalId":16600,"journal":{"name":"Journal of Ophthalmic Inflammation and Infection","volume":"15 1","pages":"56"},"PeriodicalIF":2.3,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12283504/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144690573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tubulointerstitial nephritis and uveitis (TINU) syndrome: a case series.","authors":"Richard Farnan, John Stokes, Rob Casey, Aisling McGlacken Byrne, Sean Leavey","doi":"10.1186/s12348-025-00500-x","DOIUrl":"10.1186/s12348-025-00500-x","url":null,"abstract":"<p><strong>Purpose: </strong>Tubulointerstitial nephritis and uveitis (TINU) syndrome, characterised by the co-occurrence of tubulointerstitial nephritis and uveitis in the absence of other systemic diseases, presents a diagnostic challenge due to its non-specific symptoms. This case series aims to shed light on TINU syndrome's clinical features, underlying causes, and management strategies. The prevalence of TINU syndrome is relatively low with estimates of 3.5 cases/ million people with an incidence of 0.2 cases/ million/ year and it often goes underdiagnosed. The ratio of males to females reported was 4:1. Histological confirmation through renal biopsy is crucial, while systemic conditions such as systemic lupus erythematosus, tuberculosis, sarcoidosis, and Sjogren's disease should be excluded. In most cases, TINU appears to be an idiopathic immune-mediated process, but it may be precipitated by drugs or infections. Antibiotics and non-steroidal anti-inflammatory drugs (NSAIDs) have been associated with some cases of TINU syndrome. Genetic markers, particularly HLA subtypes, have shown a strong association with TINU syndrome. Uveitis which is characterised by intraocular inflammation is a common feature of TINU syndrome. Anterior uveitis, the most prevalent form, presents with symptoms such as red eye, eye pain, photophobia, and keratic precipitates which are subdivided into granulomatous and non-granulomatous. Corticosteroids represent the primary treatment for ocular inflammation, while immunosuppressant medications may be employed for treatment of nephritis.</p><p><strong>Observations: </strong>Through the analysis of five TINU syndrome cases, this case series provides insights into the clinical presentations, laboratory findings, and biopsy results of patients with TINU syndrome. The cases include individuals with associated systemic conditions such as asthma, psoriasis and hyperthyroidism.</p><p><strong>Conclusion and importance: </strong>In conclusion, TINU syndrome is a rare condition characterised by the simultaneous occurrence of tubulointerstitial nephritis and uveitis. Increased awareness among healthcare professionals is necessary for early recognition and appropriate management of this syndrome. Further research is needed to elucidate the pathogenesis, optimise diagnostic criteria, and explore more targeted therapeutic approaches for TINU syndrome.</p>","PeriodicalId":16600,"journal":{"name":"Journal of Ophthalmic Inflammation and Infection","volume":"15 1","pages":"55"},"PeriodicalIF":2.9,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12274152/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144659470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Publisher Correction: Pharmacotherapy for non-infectious uveitis: spotlight on phase III clinical trials of locally injected or implanted therapeutics and systemic immunomodulatory drugs.","authors":"Melissa K Shields, Lisia Barros Ferreira, Syed B Ali, Liana Dedina, Lyndell L Lim, Eric B Suhler, Justine R Smith","doi":"10.1186/s12348-025-00513-6","DOIUrl":"10.1186/s12348-025-00513-6","url":null,"abstract":"","PeriodicalId":16600,"journal":{"name":"Journal of Ophthalmic Inflammation and Infection","volume":"15 1","pages":"54"},"PeriodicalIF":2.9,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12271016/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144659469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retinal and choroidal detachment following corneal wasp sting: a case report and literature review.","authors":"Shaofei Xue, Jiang Yao, Daniel Hillarion Scotland, Yuanyuan Qi","doi":"10.1186/s12348-025-00510-9","DOIUrl":"10.1186/s12348-025-00510-9","url":null,"abstract":"<p><strong>Purpose: </strong>Ocular injuries caused by wasp stings are rare but potentially devastating. This report describes a case of severe retinal and choroidal detachment secondary to corneal wasp envenomation, with a focus on pathogenesis and management challenges.</p><p><strong>Case presentation: </strong>A 63-year-old female sustained a left corneal wasp sting, progressing to corneal edema, hypopyon, retinal-choroidal detachment, and eventual light perception loss. Despite medical therapy (topical corticosteroids, antibiotics), the patient declined surgical intervention, ultimately resulting in evisceration.</p><p><strong>Conclusion: </strong>Wasp venom triggers synergistic neurotoxic and immune-mediated damage, emphasizing the necessity of individualized management. Clinicians should prioritize multimodal approaches to mitigate irreversible vision loss in such cases.</p>","PeriodicalId":16600,"journal":{"name":"Journal of Ophthalmic Inflammation and Infection","volume":"15 1","pages":"53"},"PeriodicalIF":2.9,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12263537/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144637317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical findings, outcomes following management and complications of acute retinal necrosis: the experience of a tertiary eye centre in Saudi Arabia.","authors":"Enas Magharbil, Faisal Al-Qahtani, Maram Al-Enazi, Abdulrahman H Badawi, Nora Alyousif, Moustafa S Magliyah, Hassan Al-Dhibi","doi":"10.1186/s12348-025-00511-8","DOIUrl":"10.1186/s12348-025-00511-8","url":null,"abstract":"<p><strong>Purpose: </strong>To study the clinical picture, outcomes and the complications of acute retinal necrosis (ARN) in a tertiary eye hospital.</p><p><strong>Methods: </strong>This is retrospective chart review of all patients who were diagnosed with ARN and were treated and followed up at King Khaled Eye Specialist Hospital (KKESH). Details of clinical examinations, Polymerase Chain Reaction (PCR) results, systemic and topical treatments, complications and managements of complications were obtained.</p><p><strong>Results: </strong>Twenty eight eyes of 26 patients were included. The results of PCR were positive in 22 eyes. Systemic antiviral therapy with intravenous Acyclovir 10 mg/Kg three times daily was given to all cases. Eight patients were treated with intravitreal ganciclovir injections. Fifteen eyes (56.3%) had rhegmatogenous retinal detachment (RRD) and 11 of them had surgical interventions. The risk of developing RRD was significantly high in severe vitritis (P = 0.007, OR = 3.825), diffuse or multifocal retinitis (P = 0.010, OR = 1.04) and the larger extent of retinitis (P = 0.016). The final visual outcome was worse among eyes which developed RRD (LogMAR 1.6 ± 0.94, Snellen = 20/800) than eyes which did not develop RRD (LogMAR 0.81 ± 0.84, Snellen = 20/125) and the difference was statistically significant (P = 0.031).</p><p><strong>Conclusion: </strong>The visual outcomes of ARN are significantly worse in eyes which develop RRD. More severe and larger extent of posterior segment involvement confer higher risks of RRD development in ARN.</p>","PeriodicalId":16600,"journal":{"name":"Journal of Ophthalmic Inflammation and Infection","volume":"15 1","pages":"51"},"PeriodicalIF":2.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12214190/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144540589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimal infiltration depth threshold for low-temperature plasma ablation in fungal keratitis.","authors":"Zhengwei Yang, Miaomiao Liu, Guihua Yang, Lijin Wen, Juan Yang, Hanqiao Li, Zhiwen Xie, Xie Fang, Shunrong Luo, Xianwen Xiao, Yuan Lin, Huping Wu","doi":"10.1186/s12348-025-00501-w","DOIUrl":"10.1186/s12348-025-00501-w","url":null,"abstract":"<p><strong>Purpose: </strong>To identify prognostic factors and their optimal thresholds influencing the treatment outcome of low-temperature plasma ablation therapy in patients with fungal keratitis (FK).</p><p><strong>Methods: </strong>The clinical information of fifty-one patients with FK treated with low-temperature plasma ablation at Xiamen Eye Center from 2018 to 2024 was retrospectively analyzed. Patients were categorized into Responder and Non-Responder groups based on their response to treatment: complete/partial healing (Responder group) versus disease progression or need for additional surgery (Non-Responder group). Differences in demographic and clinical characteristics between the two groups were compared. Additionally, exact univariate and multivariate logistic regression were performed to identify prognostic factors. Lastly, receiver operating characteristic (ROC) curve analysis was utilized to determine the cut-off value for significant prognostic factors.</p><p><strong>Results: </strong>Among the 51 patients, 37 were classified in the Responder group and 14 in the Non-Responder group. Univariate analysis revealed significant differences in the presence of hypopyon (p = 0.038), ulcer size (p = 0.002), infiltration depth (p = 0.001), and paracentral ulcer location (p = 0.030) between the groups. Multivariate analysis identified infiltration depth (adjusted odds ratio [aOR] = 1.41, 95% CI: 1.05-1.91, p = 0.024) as the sole significant independent prognostic factor. ROC analysis demonstrated excellent discrimination ability for infiltration depth, with an area under the curve of 0.966. Finally, the optimal threshold for infiltration depth was determined to be 0.48, exhibiting a sensitivity of 92.86% and specificity of 91.89%.</p><p><strong>Conclusions: </strong>Low-temperature plasma ablation represents an effective treatment for FK, with infiltration depth serving as a crucial prognostic indicator. The identified threshold provides valuable guidance for patient selection. Nonetheless, larger prospective studies are warranted to validate these findings.</p>","PeriodicalId":16600,"journal":{"name":"Journal of Ophthalmic Inflammation and Infection","volume":"15 1","pages":"52"},"PeriodicalIF":2.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12214183/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144540590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retrospective analysis of Vogt-Koyanagi-Harada's recurrence within a case series of nineteen patients followed between 2003 and 2018 in an academic center.","authors":"Alexandra Kozyreff, Alice Bughin, Chantal Lefebvre, Lucie Pothen, Halil Yildiz","doi":"10.1186/s12348-025-00498-2","DOIUrl":"10.1186/s12348-025-00498-2","url":null,"abstract":"","PeriodicalId":16600,"journal":{"name":"Journal of Ophthalmic Inflammation and Infection","volume":"15 1","pages":"50"},"PeriodicalIF":2.9,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12214209/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144540591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pharmacotherapy for non-infectious uveitis: spotlight on phase III clinical trials of locally injected or implanted therapeutics and systemic immunomodulatory drugs.","authors":"Melissa K Shields, Lisia Barros Ferreira, Syed B Ali, Liana Dedina, Lyndell L Lim, Eric B Suhler, Justine R Smith","doi":"10.1186/s12348-025-00502-9","DOIUrl":"10.1186/s12348-025-00502-9","url":null,"abstract":"","PeriodicalId":16600,"journal":{"name":"Journal of Ophthalmic Inflammation and Infection","volume":"15 1","pages":"49"},"PeriodicalIF":2.9,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12141190/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144234373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Concurrent uveitis in monozygotic twins in the context of systemic sarcoidosis.","authors":"Doaa Maamoun Ashour, Reem Mohsen, Rahma A Elziaty, Omnia Bahaa Attia, Haytham Samy Diab, Caroline Atef Tawfik","doi":"10.1186/s12348-025-00504-7","DOIUrl":"10.1186/s12348-025-00504-7","url":null,"abstract":"<p><strong>Purpose: </strong>To report a case of two monozygotic twins presenting with simultaneous onset of bilateral uveitis of variable phenotypic presentations, one of whom was pathologically confirmed to have sarcoidosis.</p><p><strong>Observation: </strong>Two 21-year-old monozygotic male twins (Twin A and Twin B) presented with bilateral red eyes and photophobia of six weeks' duration. Their past medical history included learning difficulties and low IQ since early childhood. Twin A was operated for Celiac Artery Compression Syndrome. Examination and work-up revealed that Twin A had bilateral anterior granulomatous uveitis, and retinal phlebitis in addition to hilar and mediastinal lymphadenopathy. A biopsy was taken, and histopathological examination showed non-caseating granuloma. Twin B had bilateral non-granulomatous anterior uveitis, chorioretinal lesions, and peripheral retinal vasculitis. Genetic testing in the form of a Whole Exome Sequencing was done, and no causal variant was detected for uveitis or sarcoidosis, however, a homozygous likely pathogenic duplication in SYNGAP1 was detected. This mutation is associated with autosomal dominant intellectual developmental disorder.</p><p><strong>Conclusion: </strong>This is the first-reported case of concurrent bilateral uveitis in monozygotic twins, with confirmed sarcoidosis in one. This presentation highlights the role of genetic predisposition and shared environmental factors in disease onset and clinical manifestations. Further research into the genetic-environmental interplay is needed to elucidate the mechanisms underlying simultaneous disease onset and guide personalized monitoring strategies for at-risk families.</p>","PeriodicalId":16600,"journal":{"name":"Journal of Ophthalmic Inflammation and Infection","volume":"15 1","pages":"48"},"PeriodicalIF":2.9,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12125438/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144187224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}