Journal of Ophthalmic Inflammation and Infection最新文献

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Clinical and radiological characteristics of odontogenic orbital cellulitis. 牙源性眼眶蜂窝织炎的临床和放射学特征。
IF 2.9
Journal of Ophthalmic Inflammation and Infection Pub Date : 2024-10-01 DOI: 10.1186/s12348-024-00422-0
Vinay Tumuluri, Jessica Y Tong, Krishna Tumuluri, Dinesh Selva
{"title":"Clinical and radiological characteristics of odontogenic orbital cellulitis.","authors":"Vinay Tumuluri, Jessica Y Tong, Krishna Tumuluri, Dinesh Selva","doi":"10.1186/s12348-024-00422-0","DOIUrl":"10.1186/s12348-024-00422-0","url":null,"abstract":"<p><strong>Purpose: </strong>To assess the radiological features and clinical outcomes of odontogenic orbital cellulitis.</p><p><strong>Method: </strong>Multi-centre retrospective study of odontogenic orbital cellulitis. Primary outcomes assessed were causal organism(s), clinical signs, radiological findings, management and visual outcomes.</p><p><strong>Results: </strong>Four patients with odontogenic orbital cellulitis were identified for inclusion. There was an equal proportion of men and women with a mean age of 43 years (range 25-56 years). All patients presented with an orbital compartment syndrome, with visual acuity of counting fingers (n = 1, 25%), hand movements (n = 1, 25%) and no perception of light (n = 2, 50%). The organisms implicated were Streptococcus milleri (n = 3, 75%) and Streptococcus constellatus (n = 1, 25%). MRI findings showed a subperiosteal abscess was present in all cases, which was characterised radiologically as a T1-hyperintense, T2 minimally hyperintense collection with restricted diffusion and a low apparent diffusion coefficient signal. Final visual acuity ranged from 6/6 to no light perception. One patient required an orbital exenteration due to extensive necrosis with sepsis and systemic deterioration.</p><p><strong>Conclusions: </strong>Odontogenic orbital cellulitis carries a serious risk of vision loss with a propensity to present with an orbital compartment syndrome secondary to Streptococcus species. Outcomes were highly variable, with two cases progressing to blindness of which one required an orbital exenteration.</p>","PeriodicalId":16600,"journal":{"name":"Journal of Ophthalmic Inflammation and Infection","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11445216/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142348543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bilateral purtscher-like retinopathy associated with DRESS syndrome: a case report. 与 DRESS 综合征相关的双侧脓肿样视网膜病变:病例报告。
IF 2.9
Journal of Ophthalmic Inflammation and Infection Pub Date : 2024-09-30 DOI: 10.1186/s12348-024-00433-x
Langxuan Yuan, Yuchen Li, Hanze Zhang, Yucen Hou, Qianyan Kang, Jianqin Lei
{"title":"Bilateral purtscher-like retinopathy associated with DRESS syndrome: a case report.","authors":"Langxuan Yuan, Yuchen Li, Hanze Zhang, Yucen Hou, Qianyan Kang, Jianqin Lei","doi":"10.1186/s12348-024-00433-x","DOIUrl":"10.1186/s12348-024-00433-x","url":null,"abstract":"<p><strong>Background: </strong>To report a case of Bilateral Purtscher-like retinopathy associated with DRESS syndrome managed with ocular and systemic treatments.</p><p><strong>Case presentation: </strong>A 29-year-old healthy female developed multi-organ (cutaneous, hematologic, renal and hepatic) disfunction and profound vision loss 1 month after Human papillomavirus vaccine injection. At the first presentation, her visual acuity was counting fingers in both eyes. Fundus exam showed remarkable cotton-wool spots, retinal hemorrhages and macular edema. She was diagnosed DRESS syndrome and Purtscher-like retinopathy and treated with intravitreal injection of ranibizumab, systemic steroids anticoagulants, and plasma exchange. The patient finally recovered from this life-threatening condition but left with permanent visual damage.</p><p><strong>Conclusion: </strong>Purtscher-like retinopathy could be complicated by DRESS syndrome which is usually considered a type IV hypersensitivity reaction.</p>","PeriodicalId":16600,"journal":{"name":"Journal of Ophthalmic Inflammation and Infection","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11442731/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142348542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tocilizumab for cystoid macular edema secondary to retinitis pigmentosa. 托西珠单抗治疗继发于视网膜色素变性的囊样黄斑水肿。
IF 2.9
Journal of Ophthalmic Inflammation and Infection Pub Date : 2024-09-30 DOI: 10.1186/s12348-024-00430-0
Stéphane Abramowicz, Prochore Kamgang Semeu, Isabelle Nubourgh, Laurence Postelmans, François Willermain
{"title":"Tocilizumab for cystoid macular edema secondary to retinitis pigmentosa.","authors":"Stéphane Abramowicz, Prochore Kamgang Semeu, Isabelle Nubourgh, Laurence Postelmans, François Willermain","doi":"10.1186/s12348-024-00430-0","DOIUrl":"10.1186/s12348-024-00430-0","url":null,"abstract":"<p><strong>Purpose: </strong>To describe the effect of tocilizumab (TCZ) on cystoid macular edema (CME) and retinal vascular leakage (RVL) in retinitis pigmentosa (RP).</p><p><strong>Methods: </strong>Retrospective case series.</p><p><strong>Results: </strong>We present 2 cases of RP with marked inflammatory features in the form of CME and RVL. There was initial diagnostic uncertainty with posterior uveitis. Both patients were treated with corticosteroids, conventional disease-modifying antirheumatic drugs (cDMARDs), and biological DMARDs (bDMARDs) for the inflammatory features with partial and inconsistent treatment response. When treatment was switched to intravenous (IV) TCZ, dramatic reduction in CME and RVL were observed in both patients. Diagnosis of RP was eventually made based on findings of ancillary tests (macular spectral-domain optical coherence tomography, visual fields, full-field electroretinogram). Genetic testing led to a molecular diagnosis of EYS-related autosomal recessive RP in patient 1, while patient 2 had negative gene panel results.</p><p><strong>Conclusions: </strong>IV TCZ can be an effective treatment option in RP-related CME and RVL. Whether this treatment strategy has an effect on prognosis remains to be established, but it is possible considering chronic CME-related retinal damage is a major driver of central vision loss in RP.</p>","PeriodicalId":16600,"journal":{"name":"Journal of Ophthalmic Inflammation and Infection","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11442707/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142348545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Occlusive retinal vasculitis associated with intravitreal Faricimab injections. 与玻璃体内注射 Faricimab 相关的闭塞性视网膜血管炎。
IF 2.9
Journal of Ophthalmic Inflammation and Infection Pub Date : 2024-09-27 DOI: 10.1186/s12348-024-00429-7
Felix F Reichel, Peter Kiraly, Roopa Vemala, Stella Hornby, Samantha R De Silva, M Dominik Fischer
{"title":"Occlusive retinal vasculitis associated with intravitreal Faricimab injections.","authors":"Felix F Reichel, Peter Kiraly, Roopa Vemala, Stella Hornby, Samantha R De Silva, M Dominik Fischer","doi":"10.1186/s12348-024-00429-7","DOIUrl":"https://doi.org/10.1186/s12348-024-00429-7","url":null,"abstract":"<p><strong>Purpose: </strong>We describe a case of occlusive vasculitis associated with intravitreal Faricimab (Vabysmo) injections.</p><p><strong>Methods: </strong>A retrospective case report.</p><p><strong>Results: </strong>A 52-year old man treated with monthly Faricimab injections for diabetic macula oedema presented with sudden reduced vision, new retinal hemorrhages, significant retinal vascular occlusions and ischemia. After screening for differential diagnoses was unremarkable, the patient was treated with oral and intravitreal steroid therapy under which the occlusive vasculitis was stabilized.</p><p><strong>Conclusion: </strong>Occlusive vasculitis, though rare, is a potential complication of Faricimab therapy. Comprehensive reporting and large-scale analyses are essential to better understand and manage this adverse event.</p>","PeriodicalId":16600,"journal":{"name":"Journal of Ophthalmic Inflammation and Infection","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2024-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11436497/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142348544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fluocinolone acetonide 0.18-mg implant for treatment of recurrent inflammation due to non-infectious uveitis: a case series of 15 patients 治疗非感染性葡萄膜炎复发性炎症的 0.18 毫克氟西诺龙醋内酯植入剂:15 例患者的病例系列研究
IF 2.9
Journal of Ophthalmic Inflammation and Infection Pub Date : 2024-09-19 DOI: 10.1186/s12348-024-00427-9
Robert A. Sisk, Daniel F. Kiernan, David Almeida, Anton M. Kolomeyer, David Eichenbaum, John W. Kitchens
{"title":"Fluocinolone acetonide 0.18-mg implant for treatment of recurrent inflammation due to non-infectious uveitis: a case series of 15 patients","authors":"Robert A. Sisk, Daniel F. Kiernan, David Almeida, Anton M. Kolomeyer, David Eichenbaum, John W. Kitchens","doi":"10.1186/s12348-024-00427-9","DOIUrl":"https://doi.org/10.1186/s12348-024-00427-9","url":null,"abstract":"Uncontrolled non-infectious uveitis affecting the posterior segment (NIU-PS) can lead to vision loss due to repeated bouts of inflammation and consequent tissue damage. Patients with chronic NIU-PS who experience recurrent uveitis after being treated with systemic and short-acting local corticosteroids may benefit from the sustained-release 0.18-mg fluocinolone acetonide implant (FAi). In this case series, 18 eyes with chronic, recurrent NIU-PS and cystoid macular edema (CME) treated with the 0.18-mg FAi were analyzed retrospectively. Data on patient demographics, clinical history, previous and concomitant treatments for uveitis recurrence, time to and number of uveitis recurrences, intraocular pressure (IOP), central subfield thickness (CST), and visual acuity (VA) were collected and summarized. A majority of patients (14/15 [93%]) had a history of ocular surgery, largely cataract extraction, and all developed chronic and recurrent NIU-PS and CME. At baseline, patients had a mean age of 72 years (range: 46 to 93), were 53% male, and had a mean duration of NIU-PS of 3 years (range: 1 to 19). Patients were followed for an average of 16.5 months (range: 2 to 42.5 months) post FAi. Eleven of the 18 eyes (61%) had ≥ 5 recurrences of uveitis since diagnosis, with an average time to recurrence of approximately 12 weeks (range: 1 to 27). All eyes treated with the 0.18-mg FAi showed reduced NIU-PS recurrence and visual and anatomical improvement, as measured by VA and CST, respectively. Two eyes had an IOP elevation that was managed with topical therapy, and one eye was treated with topical prednisolone for additional inflammation management. Two eyes required adjunct therapy with short-acting intravitreal corticosteroids at 7 and 16 weeks for NIU-PS recurrence after 0.18-mg FAi insertion. After receiving the 0.18-mg FAi, eyes with uncontrolled NIU-PS had sustained resolution of CME and inflammation with limited need for supplementary steroid drops or injections and minimal steroid class-specific adverse effects; none required incisional IOP-lowering surgery.","PeriodicalId":16600,"journal":{"name":"Journal of Ophthalmic Inflammation and Infection","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142268066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Use of in vivo confocal microscopy in suspected Acanthamoeba keratitis: a 12-year real-world data study at a Swedish regional referral center 活体共聚焦显微镜在疑似阿卡阿米巴角膜炎中的应用:瑞典地区转诊中心 12 年真实数据研究
IF 2.9
Journal of Ophthalmic Inflammation and Infection Pub Date : 2024-09-10 DOI: 10.1186/s12348-024-00424-y
Bogdana Toba, Neil Lagali
{"title":"Use of in vivo confocal microscopy in suspected Acanthamoeba keratitis: a 12-year real-world data study at a Swedish regional referral center","authors":"Bogdana Toba, Neil Lagali","doi":"10.1186/s12348-024-00424-y","DOIUrl":"https://doi.org/10.1186/s12348-024-00424-y","url":null,"abstract":"To report real-world data (RWD) on the use of in vivo confocal microscopy (IVCM) in handling cases of suspected Acanthamoeba keratitis (AK) cases at a regional referral center during a 12-year period. Retrospective study of patients with suspected AK presenting at a regional referral center for IVCM in Sweden from 2010 to 2022. Demographics, symptoms, outcomes, and clinical management were analyzed, and IVCM images were interpreted. Of 74 included patients with suspected AK, 18 (24%) were IVCM-positive, 33 (44%) were IVCM-negative, 15 had inconclusive IVCM results (20.2%), and 8 (11%) were referred for a second opinion based on IVCM, 4 of which were IVCM-positive (5.5%), yielding an overall IVCM-positive rate of 29.5%. Cultures were taken in 38 cases (51%) with only 2 cases (2.7%) culture-positive for AK. Of IVCM-negative cases, cultures were taken in 22 (67%) of cases and 100% of these were AK-negative. IVCM-positive cases had more clinic visits (median 30, P = 0.018) and longer follow-up time (median 890 days, P = 0.009) than IVCM-negative patients, while visual acuity improvement did not differ (P > 0.05). Of IVCM-positive cases, 10 (56%) underwent surgery despite prior anti-amoebic treatment, and 14 (78%) had 3 or more IVCM examinations during follow-up, with cysts (100%), dendritic cells (89%) and inflammatory infiltrate (67%) as the most prevalent features. Longitudinal IVCM indicated improvement in cysts, dendritic cells and subbasal nerves with treatment, while clinical resolution was not always consistent with complete absence of cysts. In a real-world setting, IVCM has a high reliability in classifying AK-negative cases, while IVCM detects AK-positive cases more frequently than the gold-standard culture method, leading to its preferential use over the culture method where time or resources are limited. Despite this, a subset of cases are IVCM-inconclusive, the clinical course of referred patients is long requiring many hospital visits, and visual acuity in most cases does not improve with medical treatment alone. Information sharing across centers and standardization of referral and diagnostic routines is needed to exploit the full potential of IVCM in AK patient management.","PeriodicalId":16600,"journal":{"name":"Journal of Ophthalmic Inflammation and Infection","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142185365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association between in vitro susceptibility and clinical outcomes in fungal keratitis. 真菌性角膜炎的体外易感性与临床结果之间的关系。
IF 2.9
Journal of Ophthalmic Inflammation and Infection Pub Date : 2024-09-02 DOI: 10.1186/s12348-024-00418-w
Louisa Lu, N Venkatesh Prajna, Prajna Lalitha, Revathi Rajaraman, Muthiah Srinivasan, Benjamin F Arnold, Nisha Acharya, Thomas Lietman, Jennifer Rose-Nussbaumer
{"title":"Association between in vitro susceptibility and clinical outcomes in fungal keratitis.","authors":"Louisa Lu, N Venkatesh Prajna, Prajna Lalitha, Revathi Rajaraman, Muthiah Srinivasan, Benjamin F Arnold, Nisha Acharya, Thomas Lietman, Jennifer Rose-Nussbaumer","doi":"10.1186/s12348-024-00418-w","DOIUrl":"10.1186/s12348-024-00418-w","url":null,"abstract":"<p><strong>Purpose: </strong>The purpose of this study was to assess the association between antifungal susceptibility as measured by minimum inhibitory concentration (MIC) and clinical outcomes in fungal keratitis.</p><p><strong>Methods: </strong>This pre-specified secondary analysis of the Mycotic Ulcer Treatment Trial II (MUTT II) involved patients with filamentous fungal keratitis presenting to Aravind Eye Hospitals in South India. Antifungal susceptibility testing for natamycin and voriconazole was performed on all samples with positive fungal culture results according to Clinical and Laboratory Standards Institute Guidelines. The relationship between MIC and clinical outcomes of best-corrected visual acuity, infiltrate or scar size, corneal perforation, need for therapeutic penetrating keratoplasty, and time to re-epithelialization were assessed.</p><p><strong>Results: </strong>We obtained MIC values from 141 patients with fungal keratitis. The most commonly cultured organisms were Aspergillus (46.81%, n = 66) and Fusarium (44.68%, n = 63) species. Overall, there was no association between antifungal MICs and clinical outcomes. Subgroup analysis revealed that among Fusarium-positive cases, higher voriconazole MIC was correlated with worse three-month best-corrected visual acuity (p = 0.03), increased need for therapeutic penetrating keratoplasty (p = 0.04), and time to re-epithelialization (p = 0.03). No significant correlations were found among Aspergillus-positive cases. There were no significant correlations found between natamycin MIC and clinical outcomes among organism subgroups.</p><p><strong>Conclusions: </strong>Decreased susceptibility to voriconazole was associated with increased odds of requiring a therapeutic penetrating keratoplasty in Fusarium-positive cases. Susceptibility to natamycin was not associated with any of the measured outcomes.</p>","PeriodicalId":16600,"journal":{"name":"Journal of Ophthalmic Inflammation and Infection","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2024-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11368879/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142108386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A case of adnexal cutaneous leishmaniasis in Washington DC. 华盛顿特区的一例附件皮肤利什曼病。
IF 2.9
Journal of Ophthalmic Inflammation and Infection Pub Date : 2024-08-23 DOI: 10.1186/s12348-024-00423-z
Sinan Akosman, Heeyah Song, Paul Sheils, Tamer Mansour, Keith J Wroblewski, Lamise Rajjoub
{"title":"A case of adnexal cutaneous leishmaniasis in Washington DC.","authors":"Sinan Akosman, Heeyah Song, Paul Sheils, Tamer Mansour, Keith J Wroblewski, Lamise Rajjoub","doi":"10.1186/s12348-024-00423-z","DOIUrl":"10.1186/s12348-024-00423-z","url":null,"abstract":"<p><strong>Purpose: </strong>To report a rare non-endemic case of Leishmania aethiopica in Washington DC.</p><p><strong>Case report: </strong>A 68-year-old female presented for a routine examination with a complaint of right upper eyelid lesions for the past 5 months. On examination, a cluster of elevated and erythematous lesions extending from the medial canthus to the brow area of the right eye were seen. Initial treatment with Valtrex based on a suspected viral etiology failed. Although a biopsy was recommended at this time, the patient declined, and subsequent workup included nasolacrimal duct irrigation, blood work to rule out autoimmune etiology, a course of doxycycline, and an MRI, which yielded no improvement. Upon progression of the lesions into persistent plaques on the eyelids, a punch biopsy was performed, confirming leishmaniasis. The patient was then started on a 28-day course of oral miltefosine which led to complete resolution of her symptoms.</p><p><strong>Conclusion: </strong>This case underlines the importance of a broad differential including non-endemic diseases, particularly in urban areas with frequent patient travel. Furthermore, the delayed punch biopsy in this case highlights the importance of patient counseling to ensure prompt diagnosis and treatment.</p>","PeriodicalId":16600,"journal":{"name":"Journal of Ophthalmic Inflammation and Infection","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2024-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11341790/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142036087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impact of contact lens hygiene risk factors on the prevalence of contact lens-related keratitis in Alexandria-Egypt. 埃及亚历山大市隐形眼镜卫生风险因素对隐形眼镜相关角膜炎发病率的影响。
IF 2.9
Journal of Ophthalmic Inflammation and Infection Pub Date : 2024-08-20 DOI: 10.1186/s12348-024-00421-1
Suzan Ibrahim Sakr, Amira Ahmed Nayel, Ahmed Lotfi Khattab, Waad Mahmoud Elhamamsy, Islam Abdelmonaem Abozaid, Ramy Awad, Hager AbdelKhalek Elkazaz, Christeena Saeed Habeel, Raymond Samaha, Alaa Atef Ghaith
{"title":"Impact of contact lens hygiene risk factors on the prevalence of contact lens-related keratitis in Alexandria-Egypt.","authors":"Suzan Ibrahim Sakr, Amira Ahmed Nayel, Ahmed Lotfi Khattab, Waad Mahmoud Elhamamsy, Islam Abdelmonaem Abozaid, Ramy Awad, Hager AbdelKhalek Elkazaz, Christeena Saeed Habeel, Raymond Samaha, Alaa Atef Ghaith","doi":"10.1186/s12348-024-00421-1","DOIUrl":"10.1186/s12348-024-00421-1","url":null,"abstract":"<p><strong>Background: </strong>This study aimed at measuring the effect of contact lens hygiene risk factors on the prevalence of contact lens-related keratitis and identifying the specific risk factors to both microbial and non-microbial keratitis independently.</p><p><strong>Methods: </strong>A cross-sectional study was conducted at Alexandria Ophthalmology Hospital from May to October 2023. All contact lens wearers attending the outpatient clinic had undergone face-to-face interviews using a standardized validated questionnaire which included demographic data and contact lenses (CLs) hygiene risk factors. Participants were classified into two groups; normal group and keratitis group. Keratitis group was further subdivided into non-microbial and microbial group.</p><p><strong>Results: </strong>The study included 245 contact lens wearers; 149 normal cases, 50 (20.4%) contact lens-related non-microbial keratitis (CLNK) cases, and 46 (18.8%) contact lens-related microbial keratitis (CLMK) cases. Sharing contact lenses and eye trauma were significant risk factors for both CLNK (p=0.036), (p=0.001) and CLMK (p=0.003), (p=0.017). CLs wear duration for more than 12 hours was associated with an increased risk of CLNK by about 4 times (p=0.030) and overnight wear of contact lenses increased the risk of CLNK by 2.6 times (p=0.030). Showering or swimming in lenses was identified as a significant risk factor for CLMK (p=0.012), moreover washing lenses with tap water increased the risk of CLMK (p=0.030).</p><p><strong>Conclusions: </strong>Poor compliance with contact lenses hygiene rules results in a high prevalence of contact lens-related keratitis. Eye trauma and sharing contact lenses were significant hygiene risk factors for both contact lens-related non-microbial keratitis and contact lens-related microbial keratitis.</p>","PeriodicalId":16600,"journal":{"name":"Journal of Ophthalmic Inflammation and Infection","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2024-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11336145/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142004440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Endogenous endophthalmitis secondary to Lemierre's Syndrome originating from pharyngotonsillitis. 继发于咽喉炎的雷米埃尔综合征的内源性眼内炎。
IF 2.9
Journal of Ophthalmic Inflammation and Infection Pub Date : 2024-08-16 DOI: 10.1186/s12348-024-00420-2
Nerea Gangoitia Gorrotxategi, Iñigo Salmeron Garmendia, Henar Heras-Mulero, Santiago López Arbués, Esther Compains Silva
{"title":"Endogenous endophthalmitis secondary to Lemierre's Syndrome originating from pharyngotonsillitis.","authors":"Nerea Gangoitia Gorrotxategi, Iñigo Salmeron Garmendia, Henar Heras-Mulero, Santiago López Arbués, Esther Compains Silva","doi":"10.1186/s12348-024-00420-2","DOIUrl":"10.1186/s12348-024-00420-2","url":null,"abstract":"<p><strong>Purpose: </strong>The purpose of this article is to report a case of Lemierre's Syndrome producing unilateral endogenous endophthalmitis in a healthy, young woman with a history of tonsillitis.</p><p><strong>Case report/observations: </strong>A 17-year-old healthy woman developed fever after a few days of sore throat. She later developed pneumonia with septic signs, leading to admission to the Intensive Care Unit. Lemierre Syndrome was diagnosed due to multiple septic pulmonary emboli and signs of sepsis following a recent episode of tonsillitis. During hospitalization, the patient complained of decreased visual acuity and floaters in her left eye. Ophthalmological examination revealed papillary edema, vitritis, foci of chorioretinitis in the macula and Roth's spots, confirming the diagnosis of endogenous endophthalmitis. Subsequently, she underwent appropriate treatment, progressing satisfactorily.</p><p><strong>Conclusion and importance: </strong>Although ophthalmological manifestations are rare, due to the pathophysiological characteristics of Lemierre's Syndrome, all patients should underwent standard ophthalmologic assessment, even in the absence of ophthalmic symptoms or visible findings, as part of a multidisciplinary management approach.</p>","PeriodicalId":16600,"journal":{"name":"Journal of Ophthalmic Inflammation and Infection","volume":null,"pages":null},"PeriodicalIF":2.9,"publicationDate":"2024-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11329438/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141995881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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