Recurrent strokes as the sole manifestation of antineutrophil cytoplasmic antibody associated vasculitis in a patientwith panuveitis: a case report.

IF 2.9 Q1 OPHTHALMOLOGY
Hadeel Seraj, Hanan A Alshalan, Reham Alemam, Mohammed A Omair
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引用次数: 0

Abstract

Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitides (AAV) are a heterogeneous group of rare, autoimmune conditions characterized by widespread, multisystemic inflammation of small to medium-sized blood vessels. We present a case report of a 46-year-old male with a history of prior ischemic strokes and recurrent bilateral non-granulomatous panuveitis associated with a strongly positive cytoplasmic anti-neutrophil cytoplasmic antibody (c-ANCA) titer. Initial treatment with steroids, methotrexate, and rituximab were ineffective, but the condition responded moderately to cyclophosphamide. This case underscores the importance of considering AAV in patients with unexplained ocular inflammation and highlights the role of c-ANCA testing in diagnosing and managing such cases, even in the absence of classic systemic symptoms.

复发性中风是全葡萄膜炎患者抗中性粒细胞细胞质抗体相关血管炎的唯一表现:1例报告。
抗中性粒细胞细胞质抗体(ANCA)相关血管炎(AAV)是一种罕见的异质性自身免疫性疾病,其特征是小到中等血管的广泛、多系统炎症。我们报告一例46岁男性患者,既往缺血性卒中和复发性双侧非肉芽肿性全葡萄膜炎伴强阳性细胞质抗中性粒细胞细胞质抗体(c-ANCA)滴度。最初用类固醇、甲氨蝶呤和利妥昔单抗治疗无效,但对环磷酰胺有中度反应。本病例强调了在不明原因眼部炎症患者中考虑AAV的重要性,并强调了c-ANCA检测在诊断和治疗此类病例中的作用,即使没有典型的全身症状。
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来源期刊
CiteScore
3.80
自引率
3.40%
发文量
39
审稿时长
13 weeks
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