Journal of medicinal food最新文献_第8页

Anticoagulant Effects of Albiflorin via Factor Xa Inhibition. Albiflorin通过Xa因子抑制的抗凝作用。

IF 1.8 3区农林科学

Journal of medicinal food Pub Date : 2026-03-01 Epub Date: 2026-02-10 DOI: 10.1177/1096620X261422285

Xiao-Xuan Du, Yun Hee Jeong, Gyuri Han, Jong-Sup Bae

{"title":"Anticoagulant Effects of Albiflorin via Factor Xa Inhibition.","authors":"Xiao-Xuan Du, Yun Hee Jeong, Gyuri Han, Jong-Sup Bae","doi":"10.1177/1096620X261422285","DOIUrl":"10.1177/1096620X261422285","url":null,"abstract":"Albiflorin (AF), a primary bioactive compound from the roots of Paeonia lactiflora Pall. (Peony), demonstrates anti-inflammatory, antioxidant, and cytoprotective effects. This study aims to investigate the antithrombotic potential of AF and clarify its mechanisms of action. Its anticoagulant effects were assessed via activated partial thromboplastin time, prothrombin time, thrombin, and factor Xa (FXa) activities, as well as fibrin formation and platelet aggregation. Additionally, the effect of plasminogen activator inhibitor type 1 and tissue-type plasminogen activator was evaluated in tumor necrosis factor-α-stimulated human umbilical vein endothelial cells (HUVECs). Our experiments revealed that AF exhibited antithrombotic activity comparable to that of rivaroxaban, a well-established direct FXa inhibitor, particularly in suppressing FXa activity and platelet aggregation induced by adenosine diphosphate (ADP) and U46619, a synthetic thromboxane A2 analog. AF also reduced the surface expression of P-selectin, inhibited phosphorylation of myristoylated alanine-rich C kinase substrate, and decreased PAC-1 activation following ADP or U46619 stimulation. Furthermore, AF enhanced nitric oxide production while preventing excess endothelin-1 release in HUVECs exposed to these agonists. In vivo experiments in mouse models of arterial and pulmonary thrombosis demonstrated that AF is a potent anticoagulant and antithrombotic agent. These findings indicate that AF could serve as a promising lead compound for developing innovative anti-FXa and antiplatelet therapeutics.","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":"127-136"},"PeriodicalIF":1.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146157378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction to: Effects of a Mixture of Humulus japonicus on Longitudinal Bone Growth in Hypophysectomized Rats by Kim et al. Journal of Medicinal Food 2021;24(5):497-504; doi: 10.1089/jmf.2020.4876. Kim等人更正：葎草合剂对去垂体大鼠纵骨生长的影响。药用食品学报；2021;24(5):497-504；doi: 10.1089 / jmf.2020.4876。

IF 2 3区农林科学

Journal of medicinal food Pub Date : 2026-03-01 Epub Date: 2026-04-02 DOI: 10.1089/jmf.2020.4876.correx

引用次数: 0

Black Raspberry and Phlomis Umbrosa Turcz. Extract Mixture (BLB301) Alleviates Dexamethasone-Induced Muscle Atrophy by Modulating Oxidative Stress and Protein Turnover Pathways. 黑覆盆子和黑凤仙花。提取物混合物（BLB301）通过调节氧化应激和蛋白质转换途径减轻地塞米松诱导的肌肉萎缩。

IF 1.8 3区农林科学

Journal of medicinal food Pub Date : 2026-03-01 Epub Date: 2026-01-23 DOI: 10.1177/1096620X251412890

Jeongjin Park, Woojin Jun

{"title":"Black Raspberry and Phlomis Umbrosa Turcz. Extract Mixture (BLB301) Alleviates Dexamethasone-Induced Muscle Atrophy by Modulating Oxidative Stress and Protein Turnover Pathways.","authors":"Jeongjin Park, Woojin Jun","doi":"10.1177/1096620X251412890","DOIUrl":"10.1177/1096620X251412890","url":null,"abstract":"This study aimed to evaluate the protective effects of black raspberry (Rubus occidentalis L. L.), shady Jerusalem sage (Phlomis umbrosa Turcz.), and their combination (BLB301) on dexamethasone-induced muscle atrophy using both cellular and animal models. In the former, the cytotoxicity and mRNA expression of key anabolic and catabolic markers were evaluated in C2C12 cells subjected to hydrogen peroxide (H2O2)-induced oxidative stress and treated with the extracts. In the latter, male ICR mice were assigned to the following groups: control (CON), dexamethasone injection (DEX), and DEX receiving 100 mg/kg, 200 mg/kg, or 400 mg/kg BLB301. C2C12 cells treated with BLB301 exhibited higher scavenging activity and mTOR expression than the CON and DEX cells. The mice in the DEX group exhibited significantly lower body weight (b.w.), grip strength, and muscle-to-b.w. ratios and higher oxidative stress and catabolic marker (myostatin, atrogin-1, and MuRF1) expression levels than those in the other groups. BLB301 mitigated the foregoing effects in a dose-dependent manner by increasing the antioxidant enzyme activity and decreasing the malondialdehyde levels. It also upregulated key anabolic pathways (PI3K/Akt/mTOR/S6K1) and muscle-specific transcription factors (Myf5, MyoD, and myogenin). BLB301 also downregulated the catabolic markers and restored the balance between protein synthesis and degradation. Therefore, BLB301 alleviates dexamethasone-induced muscle atrophy by modulating oxidative stress and by promoting and inhibiting anabolic and catabolic pathways, respectively. The findings of this study demonstrate the potential of BLB301 as a therapeutic agent for muscle-wasting conditions.","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":"107-115"},"PeriodicalIF":1.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146029899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enhanced Proliferation and Activation of Natural Killer Cells by Deer Antler Velvet Extract, YC-1101, and Its Synergistic Antitumor Effects in CT26 Syngeneic Mouse Model. 鹿茸提取物YC-1101增强CT26同基因小鼠自然杀伤细胞增殖、活化及其协同抗肿瘤作用

IF 1.8 3区农林科学

Journal of medicinal food Pub Date : 2026-03-01 Epub Date: 2026-02-04 DOI: 10.1177/1096620X261418535

Ji-Young Lee, Jinhui Lee, Dayoung Yeon, Jeong Seon Yoon, Sung Hwan Hwang, Sin Hwa Baek, Kun Hee Park, Aeri Song, Jeongho Jeong, Jae Won Seo, Junghwa Kang, Hyun-Je Park

{"title":"Enhanced Proliferation and Activation of Natural Killer Cells by Deer Antler Velvet Extract, YC-1101, and Its Synergistic Antitumor Effects in CT26 Syngeneic Mouse Model.","authors":"Ji-Young Lee, Jinhui Lee, Dayoung Yeon, Jeong Seon Yoon, Sung Hwan Hwang, Sin Hwa Baek, Kun Hee Park, Aeri Song, Jeongho Jeong, Jae Won Seo, Junghwa Kang, Hyun-Je Park","doi":"10.1177/1096620X261418535","DOIUrl":"10.1177/1096620X261418535","url":null,"abstract":"Deer antler velvet (Cervus elaphus L.) is a traditional material in oriental medicine, extensively utilized for its anti-aging, antioxidant, and immune-boosting properties. Our prior research revealed that enzyme-derived deer antler velvet extract (YC-1101) stimulated the immune system by activating macrophages and augmenting splenocyte proliferation. In this study, we investigated the effect of YC-1101 on the proliferation, activation, and cytotoxicity of natural killer (NK) cells, emphasizing activation-receptor upregulation, cytokine secretion, and antitumor efficacy. Our findings demonstrated that YC-1101 treatment markedly enhanced NK cell proliferation in a dose-dependent and time-dependent manner by preserving mitochondrial function. NK cells expanded through YC-1101 treatment exhibited a significant increase in surface expression of activating NK receptors, NKG2D, and NKp44. Additionally, levels of immune-related cytokines like tumor necrosis factor-alpha, interferon-gamma, and granulocyte-macrophage colony-stimulating factor were substantially elevated in the YC-1101-treated group compared with control. Notably, NK cell activation induced by YC-1101 intensified cytotoxicity against various cancer cell lines, and combining YC-1101 with immune checkpoint inhibition synergistically enhanced antitumor activity. Collectively, our results indicate that integration of YC-1101 with expanded NK cells could be a promising approach to augment cancer treatment efficacy.","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":"116-126"},"PeriodicalIF":1.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146119256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Suppressive Effect of Chrysanthemum × Morifolium Ramat. on Type I Hypersensitivity Reactions and Its Molecular Mechanism. 菊花（Chrysanthemum × Morifolium Ramat）的抑制作用。I型超敏反应及其分子机制研究

IF 1.8 3区农林科学

Journal of medicinal food Pub Date : 2026-03-01 Epub Date: 2026-03-04 DOI: 10.1177/1096620X261425894

Yuki Mitsuda, Shunsuke Kotani, Mikiyo Wada

{"title":"Suppressive Effect of Chrysanthemum × Morifolium Ramat. on Type I Hypersensitivity Reactions and Its Molecular Mechanism.","authors":"Yuki Mitsuda, Shunsuke Kotani, Mikiyo Wada","doi":"10.1177/1096620X261425894","DOIUrl":"10.1177/1096620X261425894","url":null,"abstract":"Chrysanthemum × morifolium Ramat. (CM) has long been valued as both an ornamental plant and also for its medicinal and culinary uses. In Japanese folk medicine, a decoction of CM capitulum (CMC) is taken to relieve hay fever symptoms. Previous studies have confirmed the anti-type I hypersensitivity activity of CMC, although its mechanism of action remains unclear. This study reports that two dried CMC extracts-Hachinohegiku capitulum extracts (HCE) and Abokew capitulum extracts (ACE)-among three edible CM cultivars tested, significantly inhibited passive cutaneous anaphylaxis (PCA), an in vivo model of type I hypersensitivity. In mast cell model RBL-2H3 cells, all three extracts, HCE, ACE, and Enmeiraku capitulum extracts (ECE) suppressed antigen-antibody-induced increases in intracellular Ca2+ concentration and degranulation in a concentration-dependent manner. The strength of inhibition correlated with the degree of PCA suppression. Activation of PLCγ1, a key protein in the antigen-antibody signaling cascade, was significantly inhibited only by ACE, which showed the strongest PCA inhibition. Both HCE and ACE significantly reduced Akt activation, whereas ECE, which lacked significant PCA activity, did not inhibit either protein. The degree of protein-activation inhibition corresponded with suppression of Ca2+ elevation, degranulation, and PCA response. These findings suggest that inhibition of PLCγ1 and Akt activation underlies the anti-type I hypersensitivity effects of HCE and ACE.","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":"137-146"},"PeriodicalIF":1.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147355609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bacopa monnieri-A Functional Leafy Vegetable and Medicinal Herb: A Comprehensive Review of Scientific Evidence and Proposed Mechanisms Underlying Its Influence on Circadian Rhythm. 假马齿苋-一种功能性叶菜和草药：科学证据的综合综述及其影响昼夜节律的机制。

IF 1.8 3区农林科学

Journal of medicinal food Pub Date : 2026-03-01 Epub Date: 2026-03-14 DOI: 10.1177/1096620X261425916

Maddapitigalage Dilshani Thisanjula, Dulani Somendrika, Piumi De Abrew Abeysundara

{"title":"Bacopa monnieri-A Functional Leafy Vegetable and Medicinal Herb: A Comprehensive Review of Scientific Evidence and Proposed Mechanisms Underlying Its Influence on Circadian Rhythm.","authors":"Maddapitigalage Dilshani Thisanjula, Dulani Somendrika, Piumi De Abrew Abeysundara","doi":"10.1177/1096620X261425916","DOIUrl":"10.1177/1096620X261425916","url":null,"abstract":"Bacopa monnieri (BM) is a known leafy vegetable with reported uses in traditional medicine in many countries. In traditional medicine, B. monnieri has been used to manage neurological disorders, enhance memory, and address sleep problems. As it is already recognized as a leafy vegetable suitable for consumption by both children and adults, it is timely to investigate its potential in addressing one of the most prevalent health issues in modern society-sleep disorders. This review connects traditional medicinal knowledge and modern scientific findings by examining the chronotherapeutic potential of B. monnieri. Relevant studies on B. monnieri and its effects on circadian rhythm and sleep quality were identified through a systematic and comprehensive examination of the literature. A total of 160 references, including research articles, review articles, and book chapters, were identified and summarized to provide the current scientific evidence on the effects of B. monnieri in improving sleep quality. After a thorough review, three possible pathways were identified: B. monnieri's effects on brain neurotransmitters responsible for circadian rhythm, hormonal regulation, and its effect on stress levels, which indirectly affect sleep quality. Scientific evidence supporting the use of B. monnieri for sleep or circadian regulation remains limited and has shown mixed results. Some studies report improved sleep duration and reduced stress, with strong evidence suggesting that B. monnieri has significant potential to improve sleep quality; others show no significant effect on sleep quality. Therefore, more standardized studies are needed to confirm whether B. monnieri is effective in improving sleep quality.","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":"160-177"},"PeriodicalIF":1.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147458133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Centella asiatica, Daucus carota, and Brassica oleracea Extracts Protect Against Dexamethasone-Induced Muscle Atrophy Through the Activation of the AKT/mTOR Pathway. 积雪草、胡萝卜和甘蓝提取物通过激活AKT/mTOR通路防止地塞米松诱导的肌肉萎缩。

IF 1.8 3区农林科学

Journal of medicinal food Pub Date : 2026-03-01 Epub Date: 2026-02-27 DOI: 10.1177/1096620X261426879

Eunju Jang, Tae-Baek Lee, Soobin Choi, Lisa Tonini, Da-Ye Nam, Ji-Youl Jung, Hyuk-Joon Choi, Changhwan Ahn

{"title":"Centella asiatica, Daucus carota, and Brassica oleracea Extracts Protect Against Dexamethasone-Induced Muscle Atrophy Through the Activation of the AKT/mTOR Pathway.","authors":"Eunju Jang, Tae-Baek Lee, Soobin Choi, Lisa Tonini, Da-Ye Nam, Ji-Youl Jung, Hyuk-Joon Choi, Changhwan Ahn","doi":"10.1177/1096620X261426879","DOIUrl":"10.1177/1096620X261426879","url":null,"abstract":"Degenerative muscle atrophy leads to reduced muscle mass, strength, and function, increasing the risk of falls and impairing quality of life. While plant-derived compounds possess anti-inflammatory and antioxidant properties, their capacity to mitigate muscle atrophy has not been fully explored. This study aimed to evaluate the protective effects of Centella asiatica, Daucus carota, and Brassica oleracea extracts against dexamethasone-induced muscle atrophy. In vivo experiments were conducted using a dexamethasone-induced muscle injury model in mice. Following induction of muscle atrophy, plant extracts were administered for two weeks. Muscle strength was assessed using a grip strength meter, and histological analysis was performed on the gastrocnemius tissues. All three extracts significantly restored grip strength and preserved muscle fiber size. At the molecular level, the extracts suppressed FoxO3a-mediated expression of the atrophy-related genes MuRF1 and MAFbx, while enhancing phosphorylation of Akt and mTOR. Myogenic markers MyoD and Myogenin were also upregulated. Furthermore, similar protective effects were observed in dexamethasone-treated C2C12 myotubes, including recovery of myotube diameter. Mechanistically, the extracts inhibited catabolic signaling through downregulation of FoxO3a and promoted myogenesis via activation of the Akt/mTOR pathway. These findings support the potential therapeutic application of C. asiatica, D. carota, and B. oleracea extracts for the prevention and treatment of muscle atrophy.","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":"147-159"},"PeriodicalIF":1.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147307067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anti-Inflammatory Effects of Cyrtomium falcatum (L.f.) Presl in Lipopolysaccharide-Activated BV2 Microglial Cells via MAPK and Nrf2 Signaling. 镰状细胞的抗炎作用脂多糖通过MAPK和Nrf2信号激活BV2小胶质细胞。

IF 1.8 3区农林科学

Journal of medicinal food Pub Date : 2026-02-01 Epub Date: 2026-03-16 DOI: 10.1177/1096620X261426891

Ji-Won Choi, Kyoungjin Jeon, Sang Yoon Choi, Hyun Hee L Lee, Jinyoung Hur

{"title":"Anti-Inflammatory Effects of Cyrtomium falcatum (L.f.) Presl in Lipopolysaccharide-Activated BV2 Microglial Cells via MAPK and Nrf2 Signaling.","authors":"Ji-Won Choi, Kyoungjin Jeon, Sang Yoon Choi, Hyun Hee L Lee, Jinyoung Hur","doi":"10.1177/1096620X261426891","DOIUrl":"10.1177/1096620X261426891","url":null,"abstract":"Microglia are activated in response to injury, infection, and toxic pro-inflammatory molecules that threaten neuronal survival. Long-term microglial activation plays a crucial role in the progression of neurodegenerative diseases, and negative regulators of this process have been recognized as potential therapeutic options for various neurological disorders. In this study, we evaluated the effects of Cyrtomium falcatum (L.f.) Presl (CFL) extracts on lipopolysaccharide (LPS)-induced activation of BV2 microglial cells. CFL extracts significantly reduced excessive nitric oxide production in LPS-stimulated BV2 cells and decreased the expression of inducible nitric oxide synthase, cyclooxygenase-2, and pro-inflammatory cytokines, including interleukin-1β (IL-1β), interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α). Pretreatment with CFL extracts markedly suppressed the phosphorylation of mitogen-activated protein kinases (p38, JNK, and ERK1/2) and nuclear factor kappa B and modulated the antioxidant transcription factor, nuclear factor erythroid 2-related factor 2. In conclusion, these results indicate that CFL extracts exert neuroprotective effects by inhibiting pro-inflammatory signaling pathways and modulating antioxidant defense mechanisms, suggesting their potential as therapeutic candidates for neuroinflammatory disorders.","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":"29 2","pages":"82-90"},"PeriodicalIF":1.8,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147468194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

1β,6α-Dihydroxyeudesm-4(15)-ene Protects Against MPP⁺-Induced Cytotoxicity in SH-SY5Y Cells: An In Vitro Model of Parkinson's Disease. 1β，6α-二羟基脲-4(15)-烯保护SH-SY5Y细胞免受MPP+诱导的细胞毒性：帕金森病的体外模型

IF 1.8 3区农林科学

Journal of medicinal food Pub Date : 2026-02-01 Epub Date: 2026-03-16 DOI: 10.1177/1096620X261428649

Thida Svay, Ramesh Pariyar, Tonking Bastola, Chi-Su Yoon, Eun-Sol Lee, Hyuncheol Oh, Jungwon Seo

{"title":"1β,6α-Dihydroxyeudesm-4(15)-ene Protects Against MPP+-Induced Cytotoxicity in SH-SY5Y Cells: An In Vitro Model of Parkinson's Disease.","authors":"Thida Svay, Ramesh Pariyar, Tonking Bastola, Chi-Su Yoon, Eun-Sol Lee, Hyuncheol Oh, Jungwon Seo","doi":"10.1177/1096620X261428649","DOIUrl":"10.1177/1096620X261428649","url":null,"abstract":"Parkinson's disease (PD) is a neurodegenerative disorder characterized by the progressive degeneration of the nigrostriatal dopaminergic pathway, which regulates body movements. 1-Methyl-4-phenylpyridinium (MPP+) is a widely used neurotoxin for studying the neurodegenerative process in PD models. 1β,6α-Dihydroxyeudesm-4(15)-ene (DE) is a sesquiterpene isolated from myrrh, previously reported to exhibit anti-neuroinflammatory effects. This study aimed to investigate the effects of DE on MPP+-induced cytotoxicity in SH-SY5Y cells and to elucidate the underlying molecular mechanism. We demonstrated that DE reverses MPP+-induced cell death in SH-SY5Y cells in a dose-dependent manner. DE attenuated the MPP+-induced loss of mitochondrial membrane potential, the release of cytochrome c from mitochondria, and the activation of caspase-3. In addition, DE decreased the Bax/Bcl-2 ratio as well as the production of reactive oxygen species and nitric oxide stimulated by MPP+ in SH-SY5Y cells. MPP+ treatment significantly increased the phosphorylation of extracellular signal-regulated kinases (ERKs) while decreasing the phosphorylation of p38 and c-Jun N-terminal kinases (JNKs). These effects were reversed by DE pretreatment. Furthermore, treatment with the ERK inhibitor PD98059 abolished the DE-induced protection against MPP+ cytotoxicity, and p38 inhibitor SB203580 or JNK inhibitor SP600125 mimicked DE-induced cytoprotective effects against MPP+. Our results demonstrate that DE exerts neuroprotective effects against MPP+-induced cytotoxicity by mitigating nitrosative stress, alleviating mitochondrial dysfunction, and modulating the mitogen-activated protein kinase signaling pathway, suggesting its therapeutic potential in PD.","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":"29 2","pages":"71-81"},"PeriodicalIF":1.8,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147468220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of Low-Lactose Processed Milk on Clinical Symptoms and Gut Microbiome Modulation in Lactose-Intolerant Adults. 低乳糖加工牛奶对乳糖不耐受成人临床症状和肠道微生物调节的影响

IF 1.8 3区农林科学

Journal of medicinal food Pub Date : 2026-02-01 Epub Date: 2026-01-09 DOI: 10.1177/1096620X251412892

Dong Hoon Jung, Ji-Min Cha, Ha-Neul Kim, Ye-Rin Lee, Gi Moon Nam, Chang Kyun Lee, Chul-Hong Kim, Hyun-San Lim, Ji Yeon Lee, Hee-Sook Lim

{"title":"Effect of Low-Lactose Processed Milk on Clinical Symptoms and Gut Microbiome Modulation in Lactose-Intolerant Adults.","authors":"Dong Hoon Jung, Ji-Min Cha, Ha-Neul Kim, Ye-Rin Lee, Gi Moon Nam, Chang Kyun Lee, Chul-Hong Kim, Hyun-San Lim, Ji Yeon Lee, Hee-Sook Lim","doi":"10.1177/1096620X251412892","DOIUrl":"10.1177/1096620X251412892","url":null,"abstract":"This study aimed to evaluate the effects of low-lactose processed milk consumption on body composition, clinical indicators, hydrogen breath levels, and gut microbiome changes in Korean adults with lactose intolerance. A total of 32 participants diagnosed with lactose intolerance, as determined by a hydrogen breath test, were enrolled in the study. During the 30-day intervention period, participants consumed one serving per day of banana-flavored milk containing 10.2 g of lactose. Stool and breath samples were collected before and after the intervention to assess changes in gut microbiota composition and lactose malabsorption. Following the intervention, significant improvements were observed in body composition, including reductions in body fat percentage (P < .001) and increases in fat-free mass (P < .001), skeletal muscle mass (P < .001), and soft-tissue lean mass (P < .001). Blood pressure also decreased; however, no significant changes were observed in hematological markers. Hydrogen breath test results demonstrated a significant reduction in hydrogen breath levels, and 40.6% of participants were reclassified as negative for lactose intolerance post-intervention. While no significant changes were observed in alpha diversity or overall microbial composition across all participants, a significant increase in the relative abundance of the Weissella confusa group (P = .007) was detected in individuals who tested negative for lactose intolerance after consuming the intervention food. These findings suggest that consuming low-lactose processed milk improves lactose intolerance, body composition, and gut microbiota composition, providing a feasible dietary strategy for managing lactose intolerance in adults.","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":"29 2","pages":"61-70"},"PeriodicalIF":1.8,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147468267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0