Journal of medicinal food最新文献

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Gamma-Aminobutyric Acid in Rice Bran Extract Exerts Antistress Effects in Mouse Models with Depressive-Like Behaviors. 米糠提取物中的γ-氨基丁酸在抑郁样行为小鼠模型中发挥抗抑郁作用
IF 2.4 3区 农林科学
Journal of medicinal food Pub Date : 2024-03-01 DOI: 10.1089/jmf.2023.K.0107
Ji-Hye Song, Hyunhee Kim, Min-Jeong Kong, Yoon-Taek Hong, Su-Jin Oh, Kyung-Chul Choi
{"title":"Gamma-Aminobutyric Acid in Rice Bran Extract Exerts Antistress Effects in Mouse Models with Depressive-Like Behaviors.","authors":"Ji-Hye Song, Hyunhee Kim, Min-Jeong Kong, Yoon-Taek Hong, Su-Jin Oh, Kyung-Chul Choi","doi":"10.1089/jmf.2023.K.0107","DOIUrl":"https://doi.org/10.1089/jmf.2023.K.0107","url":null,"abstract":"<p><p>Various neurotransmitters are involved in regulating stress systems. In this study, we investigated the effects of gamma-aminobutyric acid-rich rice bran extract (GRBe) in mice stressed by forced swimming and tail suspension tests. Four weeks of oral administration of GRBe (500-2000 mg/kg) reduced the levels of dopamine and corticosterone in the blood and brain while increasing serotonin levels. GRBe was involved not only in stress but also in regulating sleep and obesity-related genes. Modern society experiences diverse and tense lives because of urbanization and informatization, which cause excessive stress due to complicated interpersonal relationships, heavy work burden, and fatigue from the organized society. High levels of stress cause psychological instability and disrupt the balance in the autonomic nervous system, which maintains the body's equilibrium, resulting in cardiovascular and cerebrovascular diseases, hormonal imbalances, and sleep disorders. Therefore, our results suggest that GRBe is a useful substance that can relieve tension by ultimately influencing a depressive-like state by lowering the levels of neuronal substances, hormones, and cytokines involved in stress and sleep disorders.</p>","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140175132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Respiratory Safety Pharmacological Testing with Single Intravenous Administration of Caffeine in Sprague-Dawley Rats. 在 Sprague-Dawley 大鼠体内单次静脉注射咖啡因的呼吸安全药理测试
IF 2.4 3区 农林科学
Journal of medicinal food Pub Date : 2024-03-01 Epub Date: 2024-02-19 DOI: 10.1089/jmf.2023.K.0264
Sung-Hyun Cho, Miae Doo, Jong-Choon Kim, Jung-Heun Ha
{"title":"Respiratory Safety Pharmacological Testing with Single Intravenous Administration of Caffeine in Sprague-Dawley Rats.","authors":"Sung-Hyun Cho, Miae Doo, Jong-Choon Kim, Jung-Heun Ha","doi":"10.1089/jmf.2023.K.0264","DOIUrl":"10.1089/jmf.2023.K.0264","url":null,"abstract":"<p><p>As caffeine consumption continues to increase, both positive and negative effects are becoming evident. Caffeine directly affects the cardiovascular system, including heart function and rate. Thus, understanding the current respiratory safety pharmacological responses is of utmost importance. To elucidate the respiratory safety pharmacological characteristics of caffeine, male Sprague-Dawley rats, aged 6 weeks, were intravenously administered doses of 0, 2, 6, and 20 mg/kg of caffeine. Respiratory rate, tidal volume, and minute volume were subsequently measured. In this study, we observed a significant increase in respiratory rate and minute volume, but a remarkable reduction in tidal volume following the intravenous administration of caffeine at doses exceeding 6 mg/kg. These changes were evident within the timeframe of 0.25 to 1.5 h. The data we have collected can serve as valuable foundational scientific information for future research on caffeine, encompassing absorption, distribution, metabolism, excretion, and pharmacological core-battery experiments.</p>","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139912831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prevention of Postoperative Malnutrition with Oral Nutritional Supplements in Patients Undergoing Gastrointestinal Surgery. 通过口服营养补充剂预防胃肠道手术患者术后营养不良。
IF 2.4 3区 农林科学
Journal of medicinal food Pub Date : 2024-03-01 Epub Date: 2024-02-23 DOI: 10.1089/jmf.2023.0204
Jarosław Cwaliński, Agnieszka Cwalińska, Barbara Kuczyńska, Wiktoria Zasada, Hanna Cholerzyńska, Tomasz Banasiewicz, Jacek Paszkowski
{"title":"Prevention of Postoperative Malnutrition with Oral Nutritional Supplements in Patients Undergoing Gastrointestinal Surgery.","authors":"Jarosław Cwaliński, Agnieszka Cwalińska, Barbara Kuczyńska, Wiktoria Zasada, Hanna Cholerzyńska, Tomasz Banasiewicz, Jacek Paszkowski","doi":"10.1089/jmf.2023.0204","DOIUrl":"10.1089/jmf.2023.0204","url":null,"abstract":"<p><p>Oral nutritional supplements (ONSs) offer support for the nutritional needs of surgical patients. However, their efficacy is contingent upon the nutrient composition, absorption efficiency, and postingestion tolerance. Our study included a cohort of 84 patients who underwent elective open surgery involving at least one intestine anastomosis. To mitigate the risk of malnutrition, 2 groups of 28 patients each received either a high-protein low-osmotic ONS (Group I) or a high-calorie high-osmotic ONS (Group II). A standard diet was used in the control group (Group III). The metabolic effects were evaluated by measuring body weight and relative change in body weight (Δkg) from 24 h (-1 day) presurgery to 28 days postprocedure. Subjective tolerance following ONS consumption on the second postoperative day was also assessed. Our findings showed that, across all groups, the average body weight decreased during the initial 2 weeks postsurgery, subsequently stabilizing or returning to baseline levels by the third and fourth week of observation. Patients receiving ONS demonstrated greater weight gain between days 14 and 28, with Group I exhibiting the highest rate of gain. Low-osmotic ONS displayed superior tolerance and elicited fewer patient complaints postconsumption. Postoperative hospitalization duration did not differ significantly among the nutritional strategies. In conclusion, early administration of ONS supplies essential nutrients and facilitates refeeding, thereby reducing the risk of malnutrition. Low-osmotic preparations are better tolerated and contribute more effectively to the restoration of preoperative body weight, despite their lower caloric content.</p>","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139940068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ameliorative Effect of Macadamia Nut Protein Peptides on Acetaminophen-Induced Acute Liver Injury in Mice. 澳洲坚果蛋白肽对对乙酰氨基酚诱发的小鼠急性肝损伤的改善作用
IF 2.4 3区 农林科学
Journal of medicinal food Pub Date : 2024-03-01 Epub Date: 2024-02-20 DOI: 10.1089/jmf.2023.K.0192
Chunlan Shan, Fujun Miao, Gangjun Guo
{"title":"Ameliorative Effect of Macadamia Nut Protein Peptides on Acetaminophen-Induced Acute Liver Injury in Mice.","authors":"Chunlan Shan, Fujun Miao, Gangjun Guo","doi":"10.1089/jmf.2023.K.0192","DOIUrl":"10.1089/jmf.2023.K.0192","url":null,"abstract":"<p><p>This study aims to examine the ameliorative effect of macadamia nut protein peptides (MPP) on acetaminophen (APAP)-induced liver injury (AILI) in mice, and develop a new strategy for identifying hepatoprotective functional foods. The molecular weight distribution and amino acid composition of MPP were first studied. Forty mice were then randomized into four groups: control group (CON), APAP model group, APAP+MPP low-dose group (APAP+L-MPP), and APAP+MPP high-dose group (APAP+H-MPP). The APAP+L-MPP (320 mg/kg per day) and APAP+H-MPP (640 mg/kg per day) groups received continuous MPP gavage for 2 weeks. A 12 h of APAP (200 mg/kg) gavage resulted in liver damage. Pathological alterations, antioxidant index levels, expression of toll-like receptor 4 (TLR4)/nuclear factor-<i>κ</i>B (NF-<i>κ</i>B), and associated inflammatory factors were determined for each treatment group. The results revealed that the total amino acid content of MPP was 39.58 g/100 g, with Glu, Arg, Asp, Leu, Tyr, and Gly being the major amino acids. The molecular weight range of 0-1000 Da accounted for 73.54%, and 0-500 Da accounted for 62.84% of MPP. MPP ameliorated the pathological morphology and reduced the serum levels of alanine aminotransferase, aspartate aminotransferase, and alkaline phosphatase of AILI in mice. MPP significantly increased the activities of superoxide dismutase and glutathione peroxidase in the liver compared with the APAP group. MPP inhibited the expression of TLR4, NF-<i>κ</i>B, interleukin-1<i>β</i> (IL-1<i>β</i>), and tumor necrosis factor-<i>α</i> (TNF-<i>α</i>) genes in AILI mice. MPP also inhibited the expression levels of inflammatory factors (TNF-<i>α</i> and IL-6). Our study concludes that MPP alleviates AILI in mice by enhancing antioxidant capacity and inhibiting TLR4/NF-<i>κ</i>B pathway-related gene activation.</p>","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139931562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cytotoxic and Antitumoral Effects of Methanolic Extracts of Avocado Fruit Mesocarp in Colorectal Cancer Cell Line HT29. 酪梨果实中果皮甲醇提取物对结直肠癌细胞株 HT29 的细胞毒性和抗肿瘤作用
IF 2.4 3区 农林科学
Journal of medicinal food Pub Date : 2024-03-01 Epub Date: 2024-02-26 DOI: 10.1089/jmf.2023.0112
Gloria Yareli Gutierrez-Silerio, Pablo Garcia-Solis, Elhadi M Yahia, José David Núñez-Ríos, Francisco Vázquez-Cuevas, Pablo Alan Rodriguez-Salinas, Rolando Mendoza-Zuñiga, Aaron Kuri-García
{"title":"Cytotoxic and Antitumoral Effects of Methanolic Extracts of Avocado Fruit Mesocarp in Colorectal Cancer Cell Line HT29.","authors":"Gloria Yareli Gutierrez-Silerio, Pablo Garcia-Solis, Elhadi M Yahia, José David Núñez-Ríos, Francisco Vázquez-Cuevas, Pablo Alan Rodriguez-Salinas, Rolando Mendoza-Zuñiga, Aaron Kuri-García","doi":"10.1089/jmf.2023.0112","DOIUrl":"10.1089/jmf.2023.0112","url":null,"abstract":"<p><p>Colorectal cancer is a widespread neoplasia with high ratios of chemoresistance. Phytochemicals in plant-based extracts could be useful to treat colorectal cancer, and/or reduce chemoresistance. Methanolic extract of avocado mesocarp (MEAM) has demonstrated antitumoral properties, depending on the fruit ripening stage (RS). The aim of this study was to analyze the effects of methanolic extracts of \"Hass\" avocado fruit at different RS on cytotoxicity, antioxidative, anti-inflammatory, anti-invasive, cell cycle, and epithelial-mesenchymal transition inhibition in colorectal adenocarcinoma cell line HT29. The MEAM showed an increasing concentration of total phenolic compounds as the RS progressed, which was correlated with antioxidant capacity measured by the Ferric Reducing Antioxidant Power assay but not with the 2.2-diphenyl-1-picrylhydrazyl assay. The specific phenolic compounds of MEAM were determined by high-performance liquid chromatography, and it was found that concentrations of epicatechin decreased while concentrations of chlorogenic acid increased as the RS progressed. The HT29 cell line was treated with MEAM for 48 h, and all MEAM had a cytotoxic effect, reported by MTT assay, nevertheless, the strongest effect was associated with the presence of chlorogenic acid. MEAM induced apoptosis and cell cycle arrest in phase G0/G1, reported by flow cytometry. Moreover, MEAM inhibited cell migration evidenced by the wound healing assay. On the other hand, MEAM significantly reduced expression of mRNA of tumor necrosis factor-alpha and cyclooxygenase 2. These effects comprise important inhibition of some hallmarks of cancer. This, in turn, may provide interesting guidelines for developing antitumoral intervention agents.</p>","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139972238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association of Common Foods with Inflammation and Mortality: Analysis from a Large Prospective Cohort Study. 常见食物与炎症和死亡率的关系:一项大型前瞻性队列研究的分析。
IF 2.4 3区 农林科学
Journal of medicinal food Pub Date : 2024-03-01 Epub Date: 2024-02-14 DOI: 10.1089/jmf.2023.0203
Nicholas W Carris, Rahul Mhaskar, Emily Coughlin, Easton Bracey, Srinivas M Tipparaju, Koushik R Reddy, Hariom Yadav, Ganesh V Halade
{"title":"Association of Common Foods with Inflammation and Mortality: Analysis from a Large Prospective Cohort Study.","authors":"Nicholas W Carris, Rahul Mhaskar, Emily Coughlin, Easton Bracey, Srinivas M Tipparaju, Koushik R Reddy, Hariom Yadav, Ganesh V Halade","doi":"10.1089/jmf.2023.0203","DOIUrl":"10.1089/jmf.2023.0203","url":null,"abstract":"<p><p>Some dietary patterns are associated with inflammation, while others lower inflammation and improve health. However, many people cannot follow a complete, healthy diet. Therefore, this study's aim was to identify specific foods associated chronic inflammation and mortality. The study used Multi-Ethnic Study of Atherosclerosis (MESA) research materials from the NHLBI Biologic Specimen and Data Repository Information Coordinating Center. Three plant-based and three animal-based MESA food categories were chosen based on perceived availability in the western diet. The assessed food categories were avocado, ham, sausage, eggs, greens, and broccoli. Inflammatory markers assessed were interleukin-6 (IL-6), fibrinogen antigen, C-reactive protein, D-Dimer, interleukin-2, matrix metalloproteinase 3, necrosis factor-a soluble receptors, oxidized LDL (oxLDL), and total homocysteine. The primary outcome was the multivariable association of foods and inflammatory markers with all-cause mortality. All inflammatory makers, except oxLDL, were associated with mortality in univariate analysis. The effect was largest with IL-6 and D-dimer. The category of broccoli had the most consistent association in univariate analyses with lower inflammation and lower mortality odds. Low and high broccoli consumption versus no consumption were associated with lower mortality odds in the multivariable models with IL-6 and D-dimer. Consumption of the MESA<b>-</b>defined food category \"broccoli\" (<i>i.e.</i>, broccoli, cabbage, cauliflower, brussels sprouts, sauerkraut, and kimchee) was associated with lower inflammation and lower mortality odds. These findings should be validated in randomized controlled trials testing a \"food is medicine\" approach to identify which, if any, of these foods may have potential as an herbal therapeutic for chronic inflammation.</p>","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10954602/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139735392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of Ecklonia stolonifera Extract on Metabolic Dysregulation in High-Fat Diet-Induced Obese Mice. Ecklonia stolonifera 提取物对高脂饮食诱发肥胖小鼠代谢失调的影响
IF 2.4 3区 农林科学
Journal of medicinal food Pub Date : 2024-03-01 Epub Date: 2024-02-14 DOI: 10.1089/jmf.2023.K.0252
Su Yeon Cho, Jae Sue Choi, Un Ju Jung
{"title":"Effects of <i>Ecklonia stolonifera</i> Extract on Metabolic Dysregulation in High-Fat Diet-Induced Obese Mice.","authors":"Su Yeon Cho, Jae Sue Choi, Un Ju Jung","doi":"10.1089/jmf.2023.K.0252","DOIUrl":"10.1089/jmf.2023.K.0252","url":null,"abstract":"<p><p>This study aimed to test the hypothesis that long-term and low-dose supplementation with an ethanol extract of <i>Ecklonia stolonifera</i> may confer protection against high-fat diet (HFD)-induced obesity in mice. Male C57BL/6J mice were divided into two groups, one of which was fed an HFD (40 kcal% fat) and the other an HFD+<i>E. stolonifera</i> (0.006%, w/w, ∼5 mg/kg body weight/day) for 16 weeks. <i>E. stolonifera</i> supplementation significantly reduced body weight from week 3 and until the end of the experiment. <i>E. stolonifera</i>-supplemented mice also exhibited lower fat mass (epididymal, perirenal, and mesenteric fat) and smaller adipocyte size than HFD control mice. The two groups displayed similar food intakes, but <i>E. stolonifera</i> markedly decreased lipogenesis and increased lipolysis and fatty acid oxidation in adipose tissue. Moreover, <i>E. stolonifera</i> significantly decreased plasma and hepatic lipid levels, hepatic lipid droplet accumulation, plasma aminotransferase levels, and liver weight by decreasing lipogenesis and increasing fatty acid oxidation. As <i>E. stolonifera</i>-supplemented mice showed improvements in hyperglycemia, insulin resistance, and inflammation, compared to control mice, it is possible that the beneficial effects of <i>E. stolonifera</i> on obesity might be associated with decreased inflammation and insulin resistance. Collectively, these results indicate that <i>E. stolonifera</i> could be used as a novel means of preventing and treating obesity and obesity-related metabolic disorders.</p>","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139735451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Protective Effect of Whole Wheat on Muscle Atrophy in C2C12 Cells via Akt/FoxO1 Signaling Pathways. 全麦通过 Akt/FoxO1 信号通路对 C2C12 细胞肌肉萎缩的保护作用
IF 2.4 3区 农林科学
Journal of medicinal food Pub Date : 2024-03-01 Epub Date: 2024-01-08 DOI: 10.1089/jmf.2023.K.0164
Huijin Heo, Seonghwa Hong, Hana Lee, Jinhee Park, Kyeong-Hoon Kim, Heon-Sang Jeong, Junsoo Lee
{"title":"Protective Effect of Whole Wheat on Muscle Atrophy in C2C12 Cells via <i>Akt/FoxO1</i> Signaling Pathways.","authors":"Huijin Heo, Seonghwa Hong, Hana Lee, Jinhee Park, Kyeong-Hoon Kim, Heon-Sang Jeong, Junsoo Lee","doi":"10.1089/jmf.2023.K.0164","DOIUrl":"10.1089/jmf.2023.K.0164","url":null,"abstract":"<p><p>Skeletal muscles are important for body movement, postural maintenance, and energy metabolism. Muscle atrophy is caused by various factors, including lack of exercise, age, genetics, and malnutrition, leading to the loss of muscle mass. The <i>Akt</i>/<i>FoxO</i> signaling pathway plays a key role in the regulation of muscle protein synthesis and degradation. Whole wheat contains functional ingredients that may indirectly contribute to muscle health and function and can help prevent or slow the progression of muscle atrophy. In this study, the protective effects of three wheat cultivars (Seodun, Ol, and Shinmichal 1) against hydrogen peroxide-induced muscle atrophy in C2C12 cells were investigated. We found that whole-wheat treatment reduced reactive oxygen species production, prevented glutathione depletion, and increased myotube diameter, thereby reducing muscle atrophy by activating myoblast differentiation. Generally, \"Shinmichal 1\" exhibited the highest activation of the <i>Akt</i>/<i>FoxO</i> signaling pathway. In contrast, \"Seodun\" showed similar or slightly higher activities than those of the H<sub>2</sub>O<sub>2</sub>-treated only group. In conclusion, whole wheat exerts a protective effect against muscle atrophy by activating the <i>Akt</i>/<i>FoxO</i> signaling pathway. This study indicates that whole wheat may help prevent muscle atrophy.</p>","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139403303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prebiotic Activity of Pequi (Caryocar brasiliense Camb.) Shell on Lactobacillus and Bifidobacterium Strains: A Medicinal Food Ingredient. 枇杷(Caryocar brasiliense Camb.)壳对乳酸杆菌和双歧杆菌菌株的益生元活性:一种药用食品成分。
IF 2.4 3区 农林科学
Journal of medicinal food Pub Date : 2024-02-01 Epub Date: 2023-12-11 DOI: 10.1089/jmf.2022.0117
Aline M Alves-Santos, Monik Mariele de A Silva, Camilla Alves P Rodrigues, Thatyane Mariano R de Albuquerque, Evandro Leite de Souza, Maria Margareth V Naves
{"title":"Prebiotic Activity of Pequi (<i>Caryocar brasiliense</i> Camb.) Shell on <i>Lactobacillus</i> and <i>Bifidobacterium</i> Strains: A Medicinal Food Ingredient.","authors":"Aline M Alves-Santos, Monik Mariele de A Silva, Camilla Alves P Rodrigues, Thatyane Mariano R de Albuquerque, Evandro Leite de Souza, Maria Margareth V Naves","doi":"10.1089/jmf.2022.0117","DOIUrl":"10.1089/jmf.2022.0117","url":null,"abstract":"<p><p>Pequi is a native and popular fruit in Cerrado biome. The internal yellow-orange mesocarp is the edible fraction of the fruit, but its shell (peel and external mesocarp), which comprises 80% of the fruit, is not used by the agro-industry during fruit processing. There is a growing interest in the reduction of food loss and waste because of environmental, economic, and social impacts. So this study evaluated the chemical composition, antioxidant capacity, and <i>in vitro</i> prebiotic activity of pequi shell flour. Pequi shell flour was obtained from the lyophilization and milling of pequi shell. The content of dietary fibers, oligosaccharides, sugars, organic acids, total phenolics and tannins, polyphenol profile, and antioxidant capacity was determined in pequi shell flour. In addition, its prebiotic activity was evaluated on growth and metabolism of probiotics <i>Lactobacillus</i> and <i>Bifidobacterium</i> strains. Pequi shell flour has a high content of dietary fibers (47.92 g/100 g), soluble fibers (18.65 g/100 g), raffinose (2.39 g/100 g), and phenolic compounds (14,062.40 mg gallic acid equivalents/100 g). For the first time, the polyphenols epigallocatechin gallate, epicatechin, and procyanidin B2 were identified in this by-product. Pequi shell flour promoted greater growth of <i>Lacticaseibacillus casei</i> L-26 (at 24-48 h) and <i>Bifidobacterium animalis</i> subsp. <i>lactis</i> BB-12, as well as higher prebiotic activity scores than fructooligosaccharides (standard prebiotic). Pequi shell flour is rich in prebiotic compounds and has a high antioxidant and prebiotic potential. The promising results encourage its use as an ingredient with antioxidant and potential prebiotic properties to elaborate new functional foods and nutraceuticals.</p>","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":null,"pages":null},"PeriodicalIF":2.4,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138801666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Role of Nutraceuticals in Obesity Management: A Mechanism and Prospective Supported by Molecular Docking Studies. 营养保健品在肥胖症控制中的作用:分子对接研究支持的机理和前瞻性。
IF 2.4 3区 农林科学
Journal of medicinal food Pub Date : 2024-02-01 Epub Date: 2024-02-06 DOI: 10.1089/jmf.2023.0104
Abdel Nasser B Singab, Esraa A Elhawary, Yasmin A Elkhawas, Iten M Fawzy, Ashaimaa Y Moussa, Nada M Mostafa
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