Journal of medicinal food最新文献_第9页

Hot-Air-Dried Eruca sativa Mill. Extracts Prevent Retinal Inflammation and Unfolded Protein Responses in ARPE-19 Cells. 热风干燥的芥菜磨坊。提取物预防视网膜炎症和ARPE-19细胞的未折叠蛋白反应。

IF 1.8 3区农林科学

Journal of medicinal food Pub Date : 2026-02-01 Epub Date: 2026-01-07 DOI: 10.1177/1096620X251412888

Minseo Cho, Jisu Lee, Yoseob Kim, Young Jun Kim, Caglar Doguer, Misook Kim, Jung-Heun Ha

{"title":"Hot-Air-Dried Eruca sativa Mill. Extracts Prevent Retinal Inflammation and Unfolded Protein Responses in ARPE-19 Cells.","authors":"Minseo Cho, Jisu Lee, Yoseob Kim, Young Jun Kim, Caglar Doguer, Misook Kim, Jung-Heun Ha","doi":"10.1177/1096620X251412888","DOIUrl":"10.1177/1096620X251412888","url":null,"abstract":"Age-related macular degeneration (AMD) and diabetic retinopathy (DR) constitute leading causes of irreversible visual impairment; both are pathologically linked to chronic inflammation and endoplasmic reticulum (ER) stress in retinal pigment epithelial (RPE) cells. This study aimed to investigate the protective effects of hot-air-dried Eruca sativa Mill. extract (ESH) on lipopolysaccharide (LPS)- and thapsigargin (Tg)-induced inflammatory and ER stress responses, respectively, in ARPE-19 cells. ESH pretreatment significantly suppressed LPS-induced phosphorylation of nuclear factor kappa B (NF-κB), inhibitor of kappa B alpha, and c-Jun N-terminal kinase, indicating effective inhibition of inflammatory signaling cascades. At the transcriptional level, ESH markedly attenuated the expression of tumor necrosis factor-α mRNA, suggesting downstream prevention of NF-κB-mitogen-activated protein kinase-mediated inflammatory gene activation. Under ER stress conditions, ESH significantly attenuated the upregulation of CCAAT/enhancer-binding protein (C/EBP) homologous protein and X-box binding protein-1, along with reductions in the expressions of cleaved caspase-3 and -9, indicating mitigation of ER stress-associated retinal apoptosis. Additionally, ESH prevented Tg-inducible vascular endothelial growth factor (VEGF) mRNA expression, VEGF protein secretion, and intracellular calcium level. Strong positive correlations were observed between intracellular calcium and VEGF secretion (r = 0.888), and between VEGF mRNA and protein levels (r = 0.843), supporting a potential mechanistic link. Collectively, these findings demonstrate that ESH modulates inflammatory, ER stress, apoptotic, and angiogenic pathways, suggesting its potential as a functional dietary supplement to mitigate RPE dysfunction in AMD and DR.","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":"29 2","pages":"91-101"},"PeriodicalIF":1.8,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147468196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anti-Obesity Effect of Puffed Zingiber Officinale Ethanol Extract on 3T3-L1 Adipocytes and High-Fat Diet-Fed Mice 膨化铁皮姜乙醇提取物对小鼠3T3-L1脂肪细胞和高脂饮食的抗肥胖作用

3区农林科学

Journal of medicinal food Pub Date : 2026-01-01 DOI: 10.1177/1096620x251412893

Ye Jin Koo, Jeong Yoon Lee, Min Jeong Kim, Yoo‐Hyun Lee

{"title":"Anti-Obesity Effect of Puffed Zingiber Officinale Ethanol Extract on 3T3-L1 Adipocytes and High-Fat Diet-Fed Mice","authors":"Ye Jin Koo, Jeong Yoon Lee, Min Jeong Kim, Yoo‐Hyun Lee","doi":"10.1177/1096620x251412893","DOIUrl":"https://doi.org/10.1177/1096620x251412893","url":null,"abstract":"Obesity is a prevalent global health issue and a primary risk factor for various cardiovascular and metabolic diseases, including type 2 diabetes, hypertension, hyperlipidemia, and myocardial infarction. Although drugs targeting lipid metabolism are being developed, their adverse side effects raise safety concerns. Ginger ( Zingiber officinale ) is known for its antioxidant, anti-inflammatory, and anti-obesity effects. This study aimed to investigate the anti-obesity effects of puffed Zingiber officinale ethanol extract (PGE) both in vitro and in vivo . In vitro experiments were conducted using PGE to evaluate its enhanced anti-obesity activity. The PGE-treated group showed reduced lipid accumulation and triglyceride (TG) levels, as confirmed by Oil Red O staining and TG measurements. To assess the inhibition of adipocyte differentiation, the mRNA expression levels of key adipogenic genes, Pparγ and Cebpα , were significantly downregulated. Srebp1c , a regulator of lipogenesis, showed a significant decrease at all concentrations of PGE treatment. The expression levels of Acc , Fas , and Scd1 were reduced, while that of Cpt1 was increased. Together, these results indicate that PGE notably inhibits lipogenesis and increases fatty acid oxidation. In vivo experiments were conducted using PGE in C57BL/6J mice. PGE treatment significantly reduced body weight, improved serum lipid profiles, and lowered hepatic TG levels. It also led to a reduction in white adipose tissue and ameliorated insulin resistance. Collectively, these findings suggest the potential of PGE as a functional food ingredient for preventing and managing obesity.","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":"29 1","pages":"43-54"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147913334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sicyos angulatus Protects Against Binge-Drinking Alcohol-Induced Liver Injury by Preserving the Intestinal Barrier Integrity. 角鲨通过保持肠道屏障完整性来预防狂饮酒精性肝损伤。

IF 2 3区农林科学

Journal of medicinal food Pub Date : 2025-12-01 DOI: 10.1177/1096620X251384554

Min-Chan Kim, Hye-Rin Kim, Eun-Jung Kang, Jung-Ran Noh, Jung Hyeon Choi, Young-Keun Choi, In-Bok Lee, Dong-Hee Choi, Yun Jeong Seo, Jae Sang Park, Won Keun Oh, Yong-Hoon Kim, Chul-Ho Lee

{"title":"Sicyos angulatus Protects Against Binge-Drinking Alcohol-Induced Liver Injury by Preserving the Intestinal Barrier Integrity.","authors":"Min-Chan Kim, Hye-Rin Kim, Eun-Jung Kang, Jung-Ran Noh, Jung Hyeon Choi, Young-Keun Choi, In-Bok Lee, Dong-Hee Choi, Yun Jeong Seo, Jae Sang Park, Won Keun Oh, Yong-Hoon Kim, Chul-Ho Lee","doi":"10.1177/1096620X251384554","DOIUrl":"https://doi.org/10.1177/1096620X251384554","url":null,"abstract":"Alcoholic liver injury (ALI) is a prevalent and severe form of liver disease that lacks specific therapies, relying instead on supportive care. In ALI, gut epithelial tight junction proteins are compromised, leading to increased intestinal permeability and the translocation of endotoxins, such as lipopolysaccharides (LPS), into the bloodstream, thereby aggravating liver injury. The plant Sicyos angulatus (SA), part of the Cucurbitaceae family, is recognized for its anti-inflammatory and antioxidant effects but has not yet been studied for potential efficacy in mitigating ALI. In this study, we induced ALI in mice by administering high oral doses of ethanol following pretreatment with or without SA. The SA-treated mice exhibited significantly lower levels of plasma alanine aminotransferase and aspartate aminotransferase, markers indicative of reduced liver damage. Despite observing no notable changes in hepatic fat accumulation or expression of alcohol metabolism-related genes, we found that the SA group exhibited a marked reduction in terminal transferase dUTP nick end labeling-positive hepatocytes and reactive oxygen species within the mitochondrial fraction of liver tissue. Additionally, SA preserved intestinal barrier integrity by upregulating genes associated with tight junctions in the ileum and colon, resulting in lower LPS levels in the blood. Complementary in vitro studies with Caco-2 cells further showed that SA pretreatment protected against LPS-induced tight junction disruption by inhibiting NF-κB pathway activation. Collectively, our findings indicate that SA protects against ALI by supporting gut barrier integrity, thereby limiting LPS translocation and hepatic oxidative stress. This study underscores the potential of SA as a therapeutic agent targeting the gut-liver axis.","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":"28 12","pages":"1256-1269"},"PeriodicalIF":2.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145714677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Almond Consumption on HDL Cholesterol and CVD Risk Factors in Adults with High Cholesterol: A Randomized, Comparator-Controlled Trial. 食用杏仁对成人高胆固醇患者高密度脂蛋白胆固醇和心血管疾病危险因素的影响：一项随机对照试验

IF 2 3区农林科学

Journal of medicinal food Pub Date : 2025-12-01 Epub Date: 2025-10-08 DOI: 10.1177/1096620X251378321

Katarina M Doma, Marc Moulin, David C Crowley, Najla Guthrie, Erin D Lewis

{"title":"Almond Consumption on HDL Cholesterol and CVD Risk Factors in Adults with High Cholesterol: A Randomized, Comparator-Controlled Trial.","authors":"Katarina M Doma, Marc Moulin, David C Crowley, Najla Guthrie, Erin D Lewis","doi":"10.1177/1096620X251378321","DOIUrl":"10.1177/1096620X251378321","url":null,"abstract":"Dietary modifications are recommended for individuals with hypercholesterolemia to reduce cardiovascular disease (CVD) risk. While almonds have been shown to improve certain CVD risk factors, the effects of almonds on high-density lipoprotein cholesterol (HDL-C) are less clear. This study aimed to determine the quantity of almonds that would provide optimal increases in HDL-C in a population with hypercholesterolemia. Participants were randomized (n = 25/group) to low-dose almond (LDA; 1.5 oz/day), high-dose almond (HDA; 2.5 oz/day), or nut-free diet (NFD; cookies isocaloric to LDA) for 16 weeks. Change in HDL-C (primary outcome), Framingham Risk Score (FRS), blood pressure (BP), apolipoproteins, anthropometrics, and serum α-tocopherol were assessed at baseline and weeks 4, 8, 12, and 16. There were no significant differences in HDL-C between groups; however, there were reductions in FRS of 1.4% and 0.6% from baseline at week 16 in the HDA and LDA groups (P ≤ .05), respectively, while the NFD group had a 1.0% decrease (P = .14). There were decreases of 4.7 mmHg, 4.1 mmHg, 5.1 mmHg, and 3.8 mmHg in systolic BP for the HDA group after 4, 8, 12, and 16 weeks, respectively (P ≤ .06), which was significantly lower than the NFD group from baseline at week 8. The NFD group had increases in sagittal abdominal diameter of 4.0% and 2.7% after 4 and 8 weeks (P ≤ .05), respectively, whereas the almond groups did not. Findings suggest almond consumption may support dietary strategies for improving CVD risk factors in adults with hypercholesterolemia.","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":"1184-1193"},"PeriodicalIF":2.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145251517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gly-Pro-Val-Gly-Pro-Ser Low Molecular Weight Fish Collagen Peptide Promotes Hair Regeneration in Human Dermal Papilla Cells and C57BL/6 Mice. Gly-Pro-Val-Gly-Pro-Ser低分子量鱼胶原肽促进人真皮乳头细胞和C57BL/6小鼠毛发再生。

IF 2 3区农林科学

Journal of medicinal food Pub Date : 2025-12-01 Epub Date: 2025-08-28 DOI: 10.1177/1096620X251372008

Jamyeong Koo, Chaerin Lee, Jinhak Kim, Yuri Gwon, Wonchul Lim, Tae-Gyu Lim

{"title":"Gly-Pro-Val-Gly-Pro-Ser Low Molecular Weight Fish Collagen Peptide Promotes Hair Regeneration in Human Dermal Papilla Cells and C57BL/6 Mice.","authors":"Jamyeong Koo, Chaerin Lee, Jinhak Kim, Yuri Gwon, Wonchul Lim, Tae-Gyu Lim","doi":"10.1177/1096620X251372008","DOIUrl":"10.1177/1096620X251372008","url":null,"abstract":"Hair loss is characterized by reduced hair thickness, decreased density, and delayed growth and is associated with factors such as aging, stress, and environmental influences. This study investigated the effects of Gly-Pro-Val-Gly-Pro-Ser low molecular weight fish collagen peptide (FC) on improving hair health and alleviating hair loss. Human dermal papilla cells and C57BL/6 mice were used as experimental models. Mice were administered FC at doses of 200, 400, and 800 mg/kg body weight, followed by protein and RNA analyses and histological evaluations. The results showed that FC significantly increased the expression of vascular endothelial growth factor, PCNA, Hepatocyte growth factor, endothelial growth factor, and insulin-like growth factor 1, which play essential roles in hair follicle growth and regeneration. Additionally, FC administration reduced the expression of specific proteins negatively associated with hair health. Histological and morphological analyses revealed that FC enhanced hair follicle size, density, and overall hair quality. These findings suggest that FC may promote hair growth and regeneration.","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":"1225-1234"},"PeriodicalIF":2.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144957641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of Standardized Herbal Extract of Cynanchum wilfordii, Phlomis umbrosa, and Angelica gigas (EstroG-100®) on Physical Fatigue and Oxidative Stress in Vivo and in Vitro. 枸杞、蕨草和当归标准提取物（estog -100®）对体内和体外身体疲劳和氧化应激的影响

IF 2 3区农林科学

Journal of medicinal food Pub Date : 2025-12-01 Epub Date: 2025-11-19 DOI: 10.1177/1096620X251394920

Yoon-Young Han, Joo-Hyun Oh, Ji-Min Kim, Bo-Mi Kim, Chan-Sung Park, Yong-Wook Lee, Minhee Lee, Jeongmin Lee

{"title":"Effects of Standardized Herbal Extract of Cynanchum wilfordii, Phlomis umbrosa, and Angelica gigas (EstroG-100®) on Physical Fatigue and Oxidative Stress in Vivo and in Vitro.","authors":"Yoon-Young Han, Joo-Hyun Oh, Ji-Min Kim, Bo-Mi Kim, Chan-Sung Park, Yong-Wook Lee, Minhee Lee, Jeongmin Lee","doi":"10.1177/1096620X251394920","DOIUrl":"10.1177/1096620X251394920","url":null,"abstract":"EstroG-100®, a functional ingredient blend that has been used for menopausal health in women. However, detailed studies on its effects and their underlying mechanisms have been lacking. Herein, we evaluated the antifatigue effects of EstroG-100 using C2C12 cells exposed to oxidative stress and mice subjected to a forced swimming test. EstroG-100 significantly increased the viability and adenosine triphosphate (ATP) content of C2C12 cells under oxidative stress, while notably inhibiting the generation of reactive oxygen species. EstroG-100 tended to prolong the forced swimming time in mice. It also significantly inhibited the serum lactate dehydrogenase activity, increased intramuscular glycogen content, and upregulated the expression of peroxisme proliferator-activated receptor (PPAR)-δ and uncoupling protein (UCP)3 genes involved in β-oxidation of fatty acids. Furthermore, EstroG-100 significantly increased the activities of antioxidant enzymes, including catalase, superoxide dismutase, glutathione S-transferase, and glutathione levels, and decreased the malondialdehyde levels in the liver. These results indicate that EstroG-100 may contribute to recovery from physical fatigue by enhancing the antioxidant activity to alleviate oxidative stress and improving muscle function via modulation of glycogen and fatty acid metabolism.","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":"1205-1212"},"PeriodicalIF":2.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145604354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cardiovascular Evaluations of a Mixed Extract of Salvia Miltiorrhiza Bunge and Paeonia Lactiflora Pall. (USCP-GVH-014): A 12 Weeks Clinical Perspective. 丹参、芍药混合提取物的心血管评价。（USCP-GVH-014）： 12周临床观察

IF 2 3区农林科学

Journal of medicinal food Pub Date : 2025-12-01 Epub Date: 2025-09-10 DOI: 10.1177/1096620X251377431

Hyungyung Chai, Juah Son, Sukjin Song, Mi-Ran Cha, Byulnim Oh, Seyl Kim, Hyeon Gyu Lee, Soon Ae Kim

{"title":"Cardiovascular Evaluations of a Mixed Extract of Salvia Miltiorrhiza Bunge and Paeonia Lactiflora Pall. (USCP-GVH-014): A 12 Weeks Clinical Perspective.","authors":"Hyungyung Chai, Juah Son, Sukjin Song, Mi-Ran Cha, Byulnim Oh, Seyl Kim, Hyeon Gyu Lee, Soon Ae Kim","doi":"10.1177/1096620X251377431","DOIUrl":"10.1177/1096620X251377431","url":null,"abstract":"Salvia miltiorrhiza Bunge and Paeonia lactiflora Pall. are traditionally used to manage cardiovascular health. However, clinical evidence evaluating standardized extracts for specific cardiovascular benefits is still evolving. This study aimed to evaluate its efficacy and safety of a mixed extract of S. miltiorrhiza Bunge and P. lactiflora Pall. (USCP-GVH-014) for improving cardiovascular function in adults with early-stage vascular health decline. This 12-week, single-center, single-arm, prospective exploratory clinical trial enrolled 30 adults with at least two risk factors. Participants consumed USCP-GVH-014 (1200 mg/day), and outcomes included systolic blood pressure (SBP), carotid intima-media thickness (CIMT), lipid metabolism markers, and inflammatory markers, which were assessed at baseline, 6 weeks, and 12 weeks. USCP-GVH-014 significantly reduced SBP over time (P = .013), particularly at 12 weeks (P = .007). Total cholesterol significantly decreased at 6 weeks (P = .035), though the effect was not sustained at 12 weeks. Low-density lipoprotein cholesterol demonstrated a significant overall reduction (P = .031), but post-hoc comparisons did not confirm the significance between specific time points. CIMT significantly decreased after 12 weeks (P < .001). Additionally, improvements were observed in mean arterial pressure (P = .008), pulse pressure (P = .04), heart rate (P = .013), and right pulse wave velocity (P = .043). No serious adverse events related to the product were reported. USCP-GVH-014 may enhance vascular health by lowering SBP, reducing CIMT, and modulating lipid metabolism, highlighting its potential as a functional ingredient for cardiovascular health support.","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":"1235-1243"},"PeriodicalIF":2.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145033525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bacillus subtilis pb2441 Ameliorates Hepatic Steatosis by Decoupling Liver and Fat Tissue Lipid Accumulation in a High-Fat Diet-Fed Mouse Model. 枯草芽孢杆菌pb2441通过解耦肝脏和脂肪组织脂质积累改善高脂饮食喂养小鼠模型中的肝脏脂肪变性

IF 2 3区农林科学

Journal of medicinal food Pub Date : 2025-12-01 Epub Date: 2025-09-03 DOI: 10.1177/1096620X251372435

Jung-Yun Lee, Sung-Su Park, Il Kyu Cho, Kyoung-Sik Moon, Yangrae Cho

{"title":"Bacillus subtilis pb2441 Ameliorates Hepatic Steatosis by Decoupling Liver and Fat Tissue Lipid Accumulation in a High-Fat Diet-Fed Mouse Model.","authors":"Jung-Yun Lee, Sung-Su Park, Il Kyu Cho, Kyoung-Sik Moon, Yangrae Cho","doi":"10.1177/1096620X251372435","DOIUrl":"10.1177/1096620X251372435","url":null,"abstract":"Nonalcoholic fatty liver disease (NAFLD) is a global health issue, often associated with gut dysbiosis. In recent years, probiotics have gained attention as potential therapeutic agents for NAFLD. This study explored the effects of a single strain, Bacillus subtilis with high surfactin secretion, on C57BL/6 mice fed a high-fat diet (HFD), a model for NAFLD, for 13 weeks. We conducted efficacy assays over 13 weeks on liver fat accumulation and gut microbiome modulation. Bacillus supplementation reduced body weight gain and fat accumulation in the liver, but not in adipose tissues. This indicates a decoupling of hepatic and adipose lipid accumulation-meaning that lipid reduction occurred selectively in the liver, independent of changes in peripheral fat storage. Hepatic steatosis and liver enzyme levels were significantly improved. The supplementation largely maintained or amplified the bacterial abundance shifts caused by the HFD. Only seven-including Lactobacillus, Akkermansia, and Romboutsia-out of 53 bacterial genera which were significantly changed by HFD were restored to normal levels by the supplementation. These three genera are commonly regarded as beneficial for human health due to their roles in gut barrier integrity, immune modulation, and metabolic regulation. In contrast, despite these limited changes in bacterial composition, bacterial enzyme analysis suggested significant metabolic modulation by Bacillus supplementation. A single strain of Bacillus subtilis, instead of a mixture of multiple bacterial strains, can prevent hepatic steatosis without affecting fat tissue weight, underscoring its potential as a targeted therapeutic option through microbiome modulation of a few beneficial bacteria.","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":"1213-1224"},"PeriodicalIF":2.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144957671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Whole Montmorency Tart Cherry Smoothie Improves Disease Activity Index in Rat Model of DSS-Induced Ulcerative Colitis by Downregulating the Janus Kinase 1 and Interleukin-17A. 全蒙莫瑞西酸樱桃冰沙通过下调Janus激酶1和白细胞介素- 17a来改善dss诱导的溃疡性结肠炎模型大鼠的疾病活性指数。

IF 2 3区农林科学

Journal of medicinal food Pub Date : 2025-12-01 Epub Date: 2025-09-29 DOI: 10.1177/1096620X251383878

Johana Coronel, Marco Toc, Justin Guice, Anne Raggio, Michael J Keenan, Frank Greenway, Diana Coulon, Jack N Losso

{"title":"Whole Montmorency Tart Cherry Smoothie Improves Disease Activity Index in Rat Model of DSS-Induced Ulcerative Colitis by Downregulating the Janus Kinase 1 and Interleukin-17A.","authors":"Johana Coronel, Marco Toc, Justin Guice, Anne Raggio, Michael J Keenan, Frank Greenway, Diana Coulon, Jack N Losso","doi":"10.1177/1096620X251383878","DOIUrl":"10.1177/1096620X251383878","url":null,"abstract":"Montmorency tart cherries (TC; Prunus cerasus) are a good source of anti-inflammatory flavonoids. The aim of this research was to evaluate the protective effect of TC against ulcerative colitis (UC) in a rat model. The anthocyanin profile and content of TC were analyzed by UHPLC-PDA-MS. Rats were randomly assigned to one of eight groups (n = 6 in each group). UC was induced by adding 4% dextran sulfate solution (DSS) to the drinking water for 5 days. For the prevention, intervention, or treatment group, TC was administered orally in one or two servings (155 or 310 g of cherries/70 kg body weight/day) for 2 weeks prior to DSS administration, during the DSS administration, or after the DSS administration. Cytokines were determined by multiplex bead assay. Cyanidin-3-glucosyl-rutinoside and cyanidin-3-rutinoside were the major anthocyanins in TC extracts. TC at one or two servings reduced leukocyte infiltration in the colon. TC, as a prevention, intervention, or treatment, significantly reduced the secretion of myeloperoxidase, interleukin (IL)-6, IL-12/p40, IL-17A, tumor necrosis factor-α (TNF-α), and Janus kinase 1 (JAK1) and increased the secretion of anti-inflammatory IL-10 and JAK3. IL-1β was not significantly reduced by TC. Whole TC improved intestinal barrier function/disease activity index in UC by inhibiting IL-17A, IL-6, IL-12/p40, JAK1, and TNF-α and increasing IL-10 and JAK3 in UC rat models. TC was not inflammatory in control rats. TC has clinical potential for the treatment of UC.","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":"1175-1183"},"PeriodicalIF":2.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145191890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparing the Bioavailability of Two Seawater-Derived Magnesium Preparations. 两种海水衍生镁制剂的生物利用度比较。

IF 2 3区农林科学

Journal of medicinal food Pub Date : 2025-12-01 Epub Date: 2025-09-19 DOI: 10.1177/1096620X251380191

Brian K McFarlin, Anyla L Paschall, Molly E Kelly, Stephanie M Womack

{"title":"Comparing the Bioavailability of Two Seawater-Derived Magnesium Preparations.","authors":"Brian K McFarlin, Anyla L Paschall, Molly E Kelly, Stephanie M Womack","doi":"10.1177/1096620X251380191","DOIUrl":"10.1177/1096620X251380191","url":null,"abstract":"Magnesium deficiency is a common problem worldwide; however, existing magnesium dietary supplement sources require large doses to overcome low bioavailability. Previously research has established that seawater contains magnesium in addition to 72 other trace and ultratrace minerals, resulting in better bioavailability than traditional magnesium sources. The purpose of the present study was to compare the bioavailability of magnesium obtained from two different seawater processing methods (hydroxide vs. citrate). In a double-blind manner, healthy, young men and women (N = 20) completed three trials using a crossover design: placebo (maltodextrin), seawater magnesium citrate (Aquamin®-Mg; min 10% elemental magnesium), and seawater-derived magnesium hydroxide (Aquamin®-MgTg; min 33% elemental magnesium). Total magnesium doses were standardized on the Recommended Daily Allowance (RDA) for elemental magnesium. An incremental, 18-h urine magnesium excretion test was used to assess relative magnesium bioavailability. The urine uptake was verified by short-term serum magnesium measurements (1- and 2-h postingestion). Serum and urine magnesium concentration were analyzed in triplicate using a colorimetric assay. We found that both seawater-derived magnesium preparations significantly increased magnesium absorption compared with placebo (>97% change) but did not differ from each other when standardized on magnesium dose. The magnesium hydroxide form may be particularly useful since its greater magnesium content allows for ingestion of smaller total quantities compared to soluble magnesium citrate.","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":"1270-1273"},"PeriodicalIF":2.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145069730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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