Journal of medicinal food最新文献_第10页

UG0712, A Ginsenoside Complex, Improved Endurance Performance and Changed Hepatic and Muscular Transcriptomic Signatures in C57BL/6N Male Mice. 人参皂苷复合物 UG0712 可提高 C57BL/6N 雄性小鼠的耐力表现并改变其肝脏和肌肉转录组特征。

IF 1.7 3区农林科学

Journal of medicinal food Pub Date : 2025-02-01 Epub Date: 2024-11-25 DOI: 10.1089/jmf.2024.k.0089

Su Hyun Yu, Hea Ry Oh, Yong Hyun Park, Hye Ryeong Hong, Hyun Jin Kim, Jinbong Park, Yohan Han, Seong-Gyu Ko, Eui Cheol Shin, Tae Gyun Kim, Hyung Taek Cho, Jeong Hoon Pan, Youn Young Shim, Martin J T Reaney, Tae Jin Cho, Ji Youn Hong, Young Jun Kim, Bok Kyung Han, Geung-Joo Lee, Kangwook Lee, Seon Gil Do, Jae Kyeom Kim

{"title":"UG0712, A Ginsenoside Complex, Improved Endurance Performance and Changed Hepatic and Muscular Transcriptomic Signatures in C57BL/6N Male Mice.","authors":"Su Hyun Yu, Hea Ry Oh, Yong Hyun Park, Hye Ryeong Hong, Hyun Jin Kim, Jinbong Park, Yohan Han, Seong-Gyu Ko, Eui Cheol Shin, Tae Gyun Kim, Hyung Taek Cho, Jeong Hoon Pan, Youn Young Shim, Martin J T Reaney, Tae Jin Cho, Ji Youn Hong, Young Jun Kim, Bok Kyung Han, Geung-Joo Lee, Kangwook Lee, Seon Gil Do, Jae Kyeom Kim","doi":"10.1089/jmf.2024.k.0089","DOIUrl":"10.1089/jmf.2024.k.0089","url":null,"abstract":"Ginsenosides, active compounds derived from Panax ginseng, exhibit promising potential in enhancing physical performance. This study investigates the impact of UG0712 (UG), a novel ginsenoside compound, on endurance capacity, body weight, organ weights, blood parameters, and specific transcriptomic changes in liver and muscle tissues using a C57BL/6N mouse model. The mice received UGs orally at three doses: UG50 (50 mg/kg), UG100 (100 mg/kg), and UG200 (200 mg/kg) for a specified duration. Endurance capacity, physiological parameters, and transcriptome signatures in liver and muscle tissues were assessed. UG administration significantly improved time to exhaustion, with UG50 and UG200 showing substantial enhancements. Body and organ weights exhibited no notable differences, suggesting a lack of adverse effects. Biochemical markers, except for decreased creatine kinase levels in the UG100 group, showed no significant variations. Transcriptome analysis revealed limited group separation and dose-dependent patterns. The UG100 group displayed significant enrichment in lipid metabolism and muscle-related terms. Identified dose-dependent improvements in endurance capacity highlight UGs' potential as supplements. The absence of adverse effects on body and organ weights, along with positive effects on biochemical markers, supports their safety. Despite limited dose-dependent patterns in transcriptomic analyses, the UG100 group showcased significant enrichment in pathways related to muscle and lipid metabolism. These findings offer valuable insights for athletes and aging individuals seeking to enhance physical performance, warranting further exploration into UG effects' on molecular mechanisms.","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":"127-143"},"PeriodicalIF":1.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142695378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Buttermilk and Whey as Functional Foods to Ameliorate Clindamycin-Induced Changes in Mouse Intestine: Modulation of Intestinal Motility and Toll-like Receptors Expression. 酪乳和乳清作为功能性食品可改善克林霉素诱发的小鼠肠道变化：调节肠道运动和 Toll 样受体的表达。

IF 1.7 3区农林科学

Journal of medicinal food Pub Date : 2025-02-01 Epub Date: 2024-11-07 DOI: 10.1089/jmf.2024.0155

Andrea Bellés, Inés Abad, Berta Buey, Claudia Vergara, José Emilio Mesonero, Lourdes Sánchez, Laura Grasa

{"title":"Buttermilk and Whey as Functional Foods to Ameliorate Clindamycin-Induced Changes in Mouse Intestine: Modulation of Intestinal Motility and Toll-like Receptors Expression.","authors":"Andrea Bellés, Inés Abad, Berta Buey, Claudia Vergara, José Emilio Mesonero, Lourdes Sánchez, Laura Grasa","doi":"10.1089/jmf.2024.0155","DOIUrl":"10.1089/jmf.2024.0155","url":null,"abstract":"Antibiotic treatment is one of the main causes of intestinal dysbiosis, leading, in turn, to other intestinal alterations given the multiple relationships of the microbiota with gut health. Whey and buttermilk are two by-products from the dairy industry with numerous bioactive components. This study aimed to assess the potential of two formulas, containing a mixture of lactoferrin, milk fat globule membrane (MFGM), and whey or buttermilk, to reverse the negative effects of clindamycin on gut motility, Toll-like receptors (TLRs) expression, and oxidative stress in the intestine. For this purpose, a murine model of intestinal dysbiosis was established by clindamycin treatment. Male C57BL/6 mice were treated with saline (Control), clindamycin (Clin), a formula containing whey (F1), or buttermilk (F2) supplemented with lactoferrin and MFGM, Clin+F1, or Clin+F2. Clin delayed the whole gut transit, reduced the response to acetylcholine, decreased TLR2 expression, and increased TLR4 expression in the intestine. F1 and F2 formulas reversed the effects of Clin, restoring TLR2 receptor levels and normalizing intestinal dysmotility. These results indicate that whey- and buttermilk-based formulas supplemented with lactoferrin and MFGM could be used as functional foods to prevent or treat motility disorders and restore some components of the immune system after antibiotic treatment.","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":"205-211"},"PeriodicalIF":1.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142604505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hepatotoxic Medicinal Plants in Weight Loss Formulations Sold at Ver-o-Peso Market, Amazon Region, Brazil. 巴西亚马逊地区 Ver-o-Peso 市场销售的减肥配方中的肝毒性药用植物。

IF 1.7 3区农林科学

Journal of medicinal food Pub Date : 2025-02-01 Epub Date: 2024-11-08 DOI: 10.1089/jmf.2024.0188

Júlia Pereira Alexandre Borges, Beatriz Baia da Silva, Rafael Monteiro Fernandes, Thaís Lopes do Amaral Uchôa, Tamyris Regina Matos Lopes, José Luiz Fernandes Vieira

{"title":"Hepatotoxic Medicinal Plants in Weight Loss Formulations Sold at Ver-o-Peso Market, Amazon Region, Brazil.","authors":"Júlia Pereira Alexandre Borges, Beatriz Baia da Silva, Rafael Monteiro Fernandes, Thaís Lopes do Amaral Uchôa, Tamyris Regina Matos Lopes, José Luiz Fernandes Vieira","doi":"10.1089/jmf.2024.0188","DOIUrl":"10.1089/jmf.2024.0188","url":null,"abstract":"Obesity represents a significant global public health challenge. Various therapeutic strategies for weight reduction are available, including formulations containing medicinal plants, which are favored due to their availability and low cost. The efficacy and safety of these formulations must be evaluated as they can lead to adverse reactions, including severe hepatic injuries. Despite their widespread usage, particularly among residents of the Amazon, there is a considerable gap in knowledge regarding the species of medicinal plants used in these formulations. This study evaluated the labels of natural weight loss products sold from January to October 2022 at the Ver-o-Peso market in Belém, Brazil. A subsequent review of databases was performed to identify plants listed on the labels that were associated with hepatic injuries. In total, 54 plants were identified in these products, primarily in mixed formulations. None of the labels adhered to current legislative standards. Furthermore, nine of these plants were documented in the literature as having hepatotoxic effects, either through in vivo or in vitro studies. The presence of medicinal plants that can cause liver injury on the labels of weight loss compounds is a relevant issue requiring rigorous health surveillance intervention.","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":"212-217"},"PeriodicalIF":1.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142604529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hypoglycemic Activity of the Hydroalcoholic Extract of Porophyllum ruderale in CD1 Mice. 红景天水醇提取物对 CD1 小鼠的降血糖活性

IF 1.7 3区农林科学

Journal of medicinal food Pub Date : 2025-02-01 Epub Date: 2024-11-04 DOI: 10.1089/jmf.2024.0156

María José Vázquez-Atanacio, Mirandeli Bautista, Minarda de la O-Arciniega, Araceli Castañeda-Ovando, Manasés González-Cortazar, Armando Peláez-Acero, Deyanira Ojeda-Ramírez

{"title":"Hypoglycemic Activity of the Hydroalcoholic Extract of Porophyllum ruderale in CD1 Mice.","authors":"María José Vázquez-Atanacio, Mirandeli Bautista, Minarda de la O-Arciniega, Araceli Castañeda-Ovando, Manasés González-Cortazar, Armando Peláez-Acero, Deyanira Ojeda-Ramírez","doi":"10.1089/jmf.2024.0156","DOIUrl":"10.1089/jmf.2024.0156","url":null,"abstract":"Diabetes, considered one of the main causes of death in the Mexican population, is a chronic disease caused by alterations in the synthesis of pancreatic insulin or because it is not used effectively by the body. Insufficient action of insulin causes hyperglycemia, which, if not controlled, causes damage to blood capillaries and nerve endings over time, affecting the functioning of various organs and systems. As mentioned above, controlling glucose levels in the population suffering from chronic diseases becomes an essential part of their treatment. The aim of this study was to evaluate the hypoglycemic effect of a hydroalcoholic extract of the aerial parts of Porophyllum ruderale (HEPr). A glucose tolerance curve was developed by monitoring at different times (0-120 min) glucose levels in blood samples taken from an apical tail slice of CD1 mice. HEPr showed a significant effect from baseline on basal glucose levels (114.33 ± 14.74 mg/dL) compared with the control group (60.33 ± 4.16 mg/dL) and the metformin-treated group (129 ± 13 mg/dL). In addition, the values at the end of the tolerance curve (120 min) showed a significant decrease in the study group (66 ± 10.39 mg/dL) compared with the metformin-treated group (108.67 ± 4.50 mg/dL). This effect can be attributed to the presence of chlorogenic acid, cryptochlorogenic acid, ferulic acid, quercetin, and kaempferol 3-O-glucosides in HEPr. In conclusion, P. ruderale constitutes an important source of compounds for use as an adjuvant treatment for the control of hypoglycemia in different chronic diseases.","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":"191-197"},"PeriodicalIF":1.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142576120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of Hair Growth Promoting Activity of Standardized Soybean Extract on Testosterone-Induced Alopecia. 标准化大豆提取物对睾酮性脱发促发活性的评价。

IF 1.7 3区农林科学

Journal of medicinal food Pub Date : 2025-01-01 Epub Date: 2025-01-03 DOI: 10.1089/jmf.2023.0117

Alaa Youssef, Dalia A Al-Mahdy, Rabab H Sayed, Mouchira A Choucry, Hesham El-Askary

{"title":"Evaluation of Hair Growth Promoting Activity of Standardized Soybean Extract on Testosterone-Induced Alopecia.","authors":"Alaa Youssef, Dalia A Al-Mahdy, Rabab H Sayed, Mouchira A Choucry, Hesham El-Askary","doi":"10.1089/jmf.2023.0117","DOIUrl":"10.1089/jmf.2023.0117","url":null,"abstract":"Millions of men and women suffer from alopecia, especially androgenic alopecia (AGA), which is considered the most common form of hair loss. The available treatments for hair loss include multiple approaches, with the most popular being synthetic drugs including minoxidil and finasteride, in addition to natural products. However, synthetic drugs have shown many undesirable side effects, on the contrary, the specifications of the commonly used natural drugs have not been reported in most of the previous studies, despite the high market preference for them. One of these natural drugs is soybean (Glycine max), an economically important bean that has been reported in several studies to effectively prevent hair loss in humans and is widely used in many products treating alopecia. However, no reports were traced on the specification and standardization of the used soybean extract, which may lead to unreproducible results. Thus, in this study, we investigated the effects of different concentrations; 1%, 3%, and 5% (v/v) of a specified soybean extract (SSE) in coconut oil, using a testosterone-induced model of alopecia in adult male Wistar rats in comparison with a 2% finasteride solution. Visual and microscopical evaluations of follicular diameter, length, and density were performed. The data showed that 5% of SSE exhibited the highest activity with results comparable to standard 2% finasteride for hair diameter, length, and density, which could be attributed to the extract's isoflavone content. Genistin and diadzin isoflavones were isolated from the ethyl acetate fraction of the SSE. The total extract was standardized using high-performance liquid chromatography using genistin as a marker and showed a content of 6.2 µg/mL. Accordingly, the formulated 3% and 5% SSEs (containing 0.186 and 0.31 µg/mL of genistin, respectively) could be considered as a promising natural treatment for AGA.","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":"75-86"},"PeriodicalIF":1.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142921842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficacy and Safety of Vuong Hoat Natural Health Supplement in Managing Low Back Pain: A Randomized Clinical Trial. Vuong Hoat 天然保健品治疗腰背痛的有效性和安全性：随机临床试验。

IF 1.7 3区农林科学

Journal of medicinal food Pub Date : 2025-01-01 Epub Date: 2024-11-20 DOI: 10.1089/jmf.2023.0284

Phuong T Pham, Quan T Hoang, Lam V Trinh, Anh K Nguyen, Bo Han, Ba X Hoang

{"title":"Efficacy and Safety of Vuong Hoat Natural Health Supplement in Managing Low Back Pain: A Randomized Clinical Trial.","authors":"Phuong T Pham, Quan T Hoang, Lam V Trinh, Anh K Nguyen, Bo Han, Ba X Hoang","doi":"10.1089/jmf.2023.0284","DOIUrl":"10.1089/jmf.2023.0284","url":null,"abstract":"This clinical study aimed to assess the effectiveness and safety of Vuong Hoat (VH) natural health supplement for reducing the negative impact of low back pain, improving the quality of life, and enhancing functional activities in patients with lumbar degenerative disc disease (LDD). The open-label, randomized, controlled clinical trial involved 60 patients suffering from low back pain caused by LDD. The participants were randomly assigned to either a study group (SG) comprising 30 subjects or a control group (CG) comprising 30 subjects. Patients in the CG received treatment with electro-acupuncture, while those in the SG were administered VH in conjunction with the same electro-acupuncture protocol for 28 days. The clinical progression and tolerability of both groups were compared based on seven objective measurements: visual analog scale index, Schober test, fingertip-to-floor distance, spinal flexion, spinal extension, spinal tilt, and spinal rotation. After 14 days of treatment, the SG showed a significant improvement in overall outcomes compared to the CG. Specifically, 43.3% of SG patients achieved very good results, 53.3% had good results, and 3.4% had moderate results, whereas corresponding figures for the CG were 6.7%, 76.7%, and 16.6%, respectively (P < .05). After 28 days of treatment, both groups demonstrated a shift toward very good results, with the SG continuing to show better outcomes than the CG (P < .05). In the SG, the very good results increased to 76.7%, good results decreased to 20%, and moderate results were 3.3%. On the other hand, the CG had 46.7% very good results, 43.3% good results, and 10% moderate results. Notably, no side effects were reported from the VH treatments during the study. The findings of this study indicate that VH health supplement is a safe and effective approach for managing low back pain and limited spinal movement in patients with LDD.","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":"87-95"},"PeriodicalIF":1.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142676003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Natural Honey Proteins Prevent Diet-Induced Obesity and Metabolic Disorders in Rats. 天然蜂蜜蛋白质可预防饮食引起的大鼠肥胖和代谢紊乱。

IF 1.7 3区农林科学

Journal of medicinal food Pub Date : 2025-01-01 Epub Date: 2024-10-31 DOI: 10.1089/jmf.2024.k.0093

Atia Gohar, Richard L Atkinson, Darakhshan J Haleem, Khaled Fahmi Fawy, Muhammad Shakeel

{"title":"Natural Honey Proteins Prevent Diet-Induced Obesity and Metabolic Disorders in Rats.","authors":"Atia Gohar, Richard L Atkinson, Darakhshan J Haleem, Khaled Fahmi Fawy, Muhammad Shakeel","doi":"10.1089/jmf.2024.k.0093","DOIUrl":"10.1089/jmf.2024.k.0093","url":null,"abstract":"Previous studies have shown that oral whole honey reduces weight gain in rats on a normal diet (ND) or high-fat diet (HFD) and suppresses inflammation by modulating immunological cytokines in human neutrophils and macrophages. We hypothesize that the honey proteins (HP) are responsible for the reduced weight gain in rats on ND and HFD and that HP would alleviate obesity parameters. To test this, proteins were isolated from acacia honey through the salting-out method. Wistar rats (N = 24) were randomized to get ND or HFD for 4 weeks, then further randomized to four groups and treated with HP or saline for another 4 weeks. Energy intake (EI), body weight gain, EI per gram body weight gain, serum glucose, and lipids were measured. Expression of adipose tissue genes fatty acid binding protein (FABP), lipase C (LIPC), and apolipoprotein A-1 (APOA1) was evaluated through the quantitative polymerase chain reaction. HFD increased the body weight versus ND in weeks 1-4. HP for the next 4 weeks reduced weight gain in ND-HP and HFD-HP groups versus saline controls (P < .01). EI was not significantly different among groups. However, EI per gram body weight gain among groups was markedly different (P < .01), demonstrating reduced weight gain efficiency by HP (P < .01). HP reduced glucose in ND but not in HFD groups. Triglycerides were lower in both HP groups. The expressions of FABP, LIPC, and APOA1 genes were significantly increased (P < .05) in HP-treated HFD rats. Collectively, weight gain efficiency was remarkably reduced without altering EI in rats following the HP treatment, suggesting HP increased metabolic rate or substrate partitioning. Studies of HP are suggested in humans.","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":"68-74"},"PeriodicalIF":1.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142545979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Metabolites Generated from Foods Through Lactic Fermentation and Their Benefits on the Intestinal Microbiota and Health. 食物经乳酸发酵产生的代谢物及其对肠道微生物群和健康的益处

IF 1.7 3区农林科学

Journal of medicinal food Pub Date : 2025-01-01 Epub Date: 2024-10-30 DOI: 10.1089/jmf.2023.0218

Daniela Guzmán-Escalera, Elia Herminia Valdés-Miramontes, Laura E Iñiguez-Muñoz, Zyanya Reyes-Castillo, Ana C Espinoza-Gallardo

{"title":"Metabolites Generated from Foods Through Lactic Fermentation and Their Benefits on the Intestinal Microbiota and Health.","authors":"Daniela Guzmán-Escalera, Elia Herminia Valdés-Miramontes, Laura E Iñiguez-Muñoz, Zyanya Reyes-Castillo, Ana C Espinoza-Gallardo","doi":"10.1089/jmf.2023.0218","DOIUrl":"10.1089/jmf.2023.0218","url":null,"abstract":"Metabolites generated in foods with lactic fermentation have been subject of research in recent years due to different beneficial effects attributed to them on the microbiota and health in general, including their properties as antihypertensives, antioxidants, anti-inflammatory, immunomodulatory, and antimicrobial, among others. The present review aims to systematically analyze the results of original research that evaluates effects on the microbiota and health in general, mediated by metabolites generated from the lactic fermentation of foods. The review was carried out in the PubMed database, three studies in humans, four in vivo studies in murine models, four in vitro studies, and the rest focused on the quantification of biofunctional qualities in fermented foods were analyzed. The results of the studies compiled in this systematic review reveal the potential of different food matrices and microorganisms to generate metabolites through lactic fermentation with important properties and effects on the intestinal microbiota and other health benefits. Among these benefits is the increase in short chain fatty acids to which anti-inflammatory properties are associated, as well as bioactive peptides with antihypertensive, antithrombotic, antioxidant, anti-inflammatory, and antimicrobial properties.","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":"1-11"},"PeriodicalIF":1.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142545978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Schisandrol A Alleviates Allergic Asthma in Mice via Regulating the NF-κB/IκBα and Nrf2/HO-1 Signaling Pathways. 五味子醇 A 通过调节 NF-κB/IκBα 和 Nrf2/HO-1 信号通路缓解小鼠过敏性哮喘

IF 1.7 3区农林科学

Journal of medicinal food Pub Date : 2025-01-01 Epub Date: 2024-09-24 DOI: 10.1089/jmf.2024.k.0117

Yang Dong, Yi-Zhuo Zou, Ting Li, Jing-Hui Sun, He Li, Wen-Yue Zhuang, Yan Song, Chun-Mei Wang

{"title":"Schisandrol A Alleviates Allergic Asthma in Mice via Regulating the NF-κB/IκBα and Nrf2/HO-1 Signaling Pathways.","authors":"Yang Dong, Yi-Zhuo Zou, Ting Li, Jing-Hui Sun, He Li, Wen-Yue Zhuang, Yan Song, Chun-Mei Wang","doi":"10.1089/jmf.2024.k.0117","DOIUrl":"10.1089/jmf.2024.k.0117","url":null,"abstract":"Schisandra chinensis (Turcz) Baill (S. chinensis) is the key traditional Chinese medicine for the treatment of asthma used by ancient and modern medical practitioners. However, the material basis and the main mechanism of its antiasthmatic effect remain unclear. Our preliminary results showed that schisandrol A (SCA), a representative monomer of Schisandra lignans, had the best relaxation effect on tracheal rings in isolated rats. In this research, a mouse asthma model was prepared by combining ovalbumin (OVA) with Al (OH)3 for exploring the antiasthmatic action and the underlying mechanism of SCA. The study results demonstrated that SCA improved the behavior of mice with asthma and pathological changes in their lung tissues and airways, decreased serum immunoglobulin E (IgE) and OVA-IgE levels, interleukin-4 (IL-4), IL-5, IL-13, and eotaxin contents, and leukocytes number in bronchoalveolar lavage fluid. SCA downregulated the gene expressions of keratinocyte-derived protein chemokines and ILs and reduced the expressions of phosphorylated IκB kinase α (p-IKKα) and p-nuclear factor kappa-B (NF-κB) proteins in lung tissues. In addition, it was found that SCA could significantly increase T-superoxide dismutase and catalase activities, decrease malondialdehyde content, and elevate p-IκBα, NF-E2-related-factor 2 (Nrf2), and heme oxygenase-1 (HO-1) protein expressions. In summary, SCA treatment resulted in a significant improvement in the allergic bronchial asthma in mice, and its mechanisms may involve the regulation of the NF-κB/IκBα pathway to reduce inflammatory response and the Nrf2/HO-1 pathway to improve the body's antioxidant capacity. These results suggest that SCA is a key component of S. chinensis in exerting antiasthmatic effects.","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":"28-37"},"PeriodicalIF":1.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142307951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Cervus Elaphus and Eucommia Ulmoides Extract Blend Attenuates Muscle Atrophy by Regulating Protein Metabolism and Antioxidant Activity. 马鹿杜仲提取物通过调节蛋白质代谢和抗氧化活性减轻肌肉萎缩。

IF 1.7 3区农林科学

Journal of medicinal food Pub Date : 2025-01-01 Epub Date: 2024-12-30 DOI: 10.1089/jmf.2024.k.0220

Jeongjin Park, Gi-Bang Koo, Han Ol Kwon, Jong Han Kim, Woojin Jun

{"title":"A Cervus Elaphus and Eucommia Ulmoides Extract Blend Attenuates Muscle Atrophy by Regulating Protein Metabolism and Antioxidant Activity.","authors":"Jeongjin Park, Gi-Bang Koo, Han Ol Kwon, Jong Han Kim, Woojin Jun","doi":"10.1089/jmf.2024.k.0220","DOIUrl":"10.1089/jmf.2024.k.0220","url":null,"abstract":"Here, we investigated whether a mixture of Cervus elaphus and Eucommia ulmoides (1:3, KGC01CE) could suppress muscle atrophy in H2O2-induced C2C12 cells and dexamethasone-injected mice. Our results revealed that KGC01CE effectively safeguarded against H2O2-induced muscle atrophy in C2C12 cells compared with the same mixture at other ratios. We demonstrated that dexamethasone elicited oxidative stress in muscle tissue and decreased the grip strength and cross-sectional areas of muscle fibers; however, oral administration of KGC01CE (1:3) suppressed these dexamethasone-induced changes. Furthermore, oral KGC01CE (1:3) administration suppressed the expression of protein degradation-associated factors, myostatin, muscle RING finger 1, and atrogin-1 in muscle tissue from dexamethasone-injected mice. Oral KGC01CE administration stimulated protein synthesis by stimulating the PI3K/Akt/mTOR pathway in muscle tissue from dexamethasone-injected mice. These findings indicate that KGC01CE can suppress dexamethasone injection-induced muscle atrophy by inhibiting protein degradation and promoting muscle hypertrophy. Therefore, KGC01CE supplementation helps prevent muscle atrophy in mice and may be beneficial against various components of muscle atrophy.","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":"58-67"},"PeriodicalIF":1.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142895542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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