Journal of medicinal food最新文献

{"title":"C-Phycocyanin: A Phycobiliprotein from <i>Spirulina</i> with Metabolic Syndrome and Oxidative Stress Effects.","authors":"Van D Castro-Gerónimo, Rosa Virginia García-Rodríguez, Alberto Sánchez-Medina, German A Chamorro-Cevallos, Dolores Javier Sánchez-González, Enrique Méndez-Bolaina","doi":"10.1089/jmf.2022.0113","DOIUrl":"10.1089/jmf.2022.0113","url":null,"abstract":"<p><p><i>Spirulina maxima</i> is a cyanobacterium considered a \"superfood\" due to its metabolites and nutrient content. These include a complex mixture of minerals, vitamins, fatty acids, proteins, and accessory pigments. In recent years, it has positioned itself as a promising source of bioactive molecules for the treatment of several diseases, including metabolic syndrome, coronary diseases, cancer, and the improvement of health modulating oxidative stress. C-Phycocyanin (C-PC) is a photosynthetic pigment from green-blue cyanobacterium and the most abundant phycobiliprotein in the Spirulina genus with various pharmacological properties attributed due to its antioxidant capacity but has no specific cellular target. This has made it a molecule of great interest in biomedical research. This review focuses on the pharmacological effects and the benefits on metabolic syndrome and oxidative stress of C-PC.</p>","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":"807-813"},"PeriodicalIF":1.7,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10508326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prebiotic Potential of Goji Berry (<i>Lycium barbarum</i>) in Improving Intestinal Integrity and Inflammatory Profiles via Modification of the Gut Microbiota in High-Fat Diet-Fed Rats.","authors":"Eunji Jeong, Sungjin Eun, Seoyeon Chae, Sunhye Lee","doi":"10.1089/jmf.2024.k.0031","DOIUrl":"10.1089/jmf.2024.k.0031","url":null,"abstract":"<p><p><i><b>Background:</b></i> Imbalances in gut microbiota and subsequent destabilization of intestinal barrier equilibrium have been related to the evolution of metabolic disorders. Goji berries (Lycium barbarum; GB) and their fermented counterpart (FGB) have been identified for their prebiotic capacity in managing intestinal barrier functions and inflammatory profiles Consequently, this research was designed to investigate the effects of supplementing GB and FGB on intestinal integrity, inflammation, and changes in the composition of gut microbiota in high-fat (HF)-fed rats. <i><b>Materials and Methods:</b></i> Thirty-two male Sprague-Dawley rats (6 weeks old, 8 per group) were divided into four categories based on their weight and provided with either respective diets over a 6-week period: low-fat (LF; 10% of calories from fat), HF (45% of calories from fat), and HF diets supplemented with either GB or FGB at a 2% (w/w). <i><b>Results:</b></i> Supplementation of GB and FGB resulted in compositional changes in the gut microbiota, denoted by a distinct abundance of Faecalibacterium prausnitzii with GB and Akkermansia muciniphila species with FGB, which have been linked to ameliorated obesity phenotypes and metabolic parameters. These alterations were correlated with enhancements in gut barrier integrity, thereby protecting against local and systemic inflammation induced by a HF diet. Supplementation with GB and FGB also mitigated lipopolysaccharide-induced inflammation through inhibition of its downstream pathway. <i><b>Conclusion:</b></i> These findings indicate that both GB and FGB supplementation can improve gut barrier function and inflammatory profiles in HF-fed rats via modulation of the microbial composition of the gut, supporting the potential application of GB and FGB in improving gut barrier function and managing inflammation amid metabolic challenges.</p>","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":"704-712"},"PeriodicalIF":1.7,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141476760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Supplementation with a Probiotic Formula Having β-Glucuronidase Activity Modulates Serum Estrogen Levels in Healthy Peri- and Postmenopausal Women.","authors":"Shinichi Honda, Yuji Tominaga, Jordi Espadaler-Mazo, Pol Huedo, Meritxell Aguiló, Marta Perez, Takahiro Ueda, Jinko Sawashita","doi":"10.1089/jmf.2023.k.0320","DOIUrl":"10.1089/jmf.2023.k.0320","url":null,"abstract":"<p><p>Declines in estrogen levels occur in women transitioning to menopause. Estrogen hormones play important roles in multiple systems of the body, and estrogen loss is associated with a variety of symptoms that can decrease quality of life. The gut microbiota is involved in regulating endogenous estrogen levels. A portion of estrogen glucuronides can be reactivated in the gut by the microbial enzyme β-glucuronidase, and the resulting free estrogens can return to the bloodstream. Here, we carried out <i>in vitro</i> screening of β-glucuronidase activities for 84 strains belonging to 16 different species of lactic acid bacteria and bifidobacteria and found that one and three strains of <i>Levilactobacillus brevis</i> and <i>Lacticasebacillus rhamnosus</i>, respectively, can deconjugate estrogens. Among these strains, <i>L. brevis</i> KABP052 had the highest β-glucuronidase activity. Moreover, in an exploratory, randomized, double-blind, placebo-controlled trial, we demonstrated that serum estrogen levels in healthy peri- and postmenopausal women given a probiotic formula containing KABP052 were maintained over time, whereas levels significantly decreased in the group given a placebo. Significantly higher levels of estradiol (31.62 ± 7.97 pg/mL vs. 25.12 ± 8.17 pg/mL) and estrone (21.38 ± 8.57 pg/mL vs. 13.18 ± 8.77 pg/mL) were observed in the probiotic versus placebo group after 12 weeks of intervention. This clinical study demonstrated for the first time the estrogen modulation capacity of a probiotic formula containing a bacterial strain having β-glucuronidase activity in women during the menopausal transition and formed the basis for future investigations using probiotics in the menopausal population.</p>","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":"720-727"},"PeriodicalIF":1.7,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140921911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>Coix</i> Sprouts Affect Triglyceride Metabolism in Huh7 Cells and High-Fat Diet-Induced Obese Mice.","authors":"Mi-Rae Shin, Min Ju Kim, Jin A Lee, Eun Song Lee, Hae-Jin Park, Seong-Soo Roh","doi":"10.1089/jmf.2023.k.0246","DOIUrl":"10.1089/jmf.2023.k.0246","url":null,"abstract":"<p><p>Lipolysis is the hydrolysis of triglycerides (TGs), commonly known as fats. Intracellular lipolysis of TG is associated with adipose triglyceride lipase (ATGL), which provides fatty acids during times of metabolic need. The aim of this study was to determine whether <i>Coix lacryma-jobi</i> L. <i>var. ma-yuen</i> Stapf (<i>Coix</i>) sprouts (CS) can alleviate obesity through lipolysis. Overall, we investigated the potential of CS under <i>in vitro</i> and <i>in vivo</i> conditions and confirmed the underlying mechanisms. Huh7 cells were exposed to free fatty acids (FFAs), and C57BL/6J mice were fed a 60% high-fat diet. When FFA were introduced into Huh7 cells, the intracellular TG levels increased within the Huh7 cells. However, CS treatment significantly reduced intracellular TG levels. Furthermore, CS decreased the expression of <i>Pparγ</i> and <i>Srebp1c</i> mRNA and downregulated the mutant <i>Pnpla3</i> (I148M) mRNA. Notably, CS significantly upregulated ATGL expression. CS treatment at a dose of 200 mg/kg/day resulted in a significant and dose-dependent decrease in body weight gain and epididymal adipose tissue weight. Specifically, the group treated with CS (200 mg/kg/day) exhibited a significant modulation of serum lipid biomarkers. In addition, CS ameliorated histological alterations in both the liver and adipose tissues. In summary, CS efficiently inhibited lipid accumulation through the activation of the lipolytic enzyme ATGL coupled with the suppression of enzymes involved in TG synthesis. Consequently, CS show promise as a potential anti-obesity agent.</p>","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":"728-739"},"PeriodicalIF":1.7,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141161259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improvement in Testosterone Production by <i>Acorus gramineus</i> for the Alleviation of Andropause Symptoms.","authors":"Jeong Yoon Lee, Seokho Kim, Hongeun Kim, Sung-Hum Yeon, Sang-Yoon Kim, Rak Ho Son, Chae Lee Park, Yoo-Hyun Lee","doi":"10.1089/jmf.2023.k.0332","DOIUrl":"10.1089/jmf.2023.k.0332","url":null,"abstract":"<p><p><i>Acorus gramineus</i> has a number of beneficial effects, including protective effects against age-related disorders. In this study, the effects of <i>A. gramineus</i> on testosterone production and andropause symptoms were evaluated. We first treated TM3 mouse Leydig cells, responsible for testosterone production, with <i>A. gramineus</i> aqueous extract at different concentrations. In TM3 cells, the testosterone concentration increased in a concentration-dependent manner compared with those in the control. In addition, at 400 μg/mL extract, the mRNA expression level of the steroidogenic enzyme <i>CYP11A1</i> was increased. Subsequently, 23-week-old Sprague-Dawley (SD) rats exhibiting an age-related reduction in serum testosterone (approximately 80% lower than that in 7-week-old SD rats) were administered <i>A. gramineus</i> aqueous extract for 8 weeks. Serum total testosterone and free testosterone levels were higher and serum estradiol, prostate-specific antigen levels, and total cholesterol levels were lower in the AG50 group (<i>A. gramineus</i> aqueous extract 50 mg/kg of body weight/day) than in the OLD (control group). The AG50 group also showed significant elevations in sperm count, grip strength, and mRNA expression of <i>StAR</i>, <i>CYP11A1</i>, <i>17β-HSD</i>, and <i>CYP17A1</i> compared with those in the OLD group. In conclusion, <i>A. gramineus</i> aqueous extract facilitated steroidogenesis in Leydig cells, elevated testosterone levels, lowered serum estradiol and total cholesterol levels, and increased muscle strength and sperm count, thus alleviating the symptoms of andropause. These findings suggest that <i>A. gramineus</i> aqueous extract is a potentially effective therapeutic agent against various symptoms associated with andropause.</p>","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":"740-748"},"PeriodicalIF":1.7,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141200001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Physicochemical Characterization of Yogurt Fortified with Microencapsulated Cinnamon (<i>Cinnamomum zeylanicum</i>) and Its Effects on Metabolic Syndrome Induced in Rabbits (<i>Oryctolagus cuniculus</i>).","authors":"María Fernanda Riós Pérez, Aurora Quintero Lira, Javier Piloni Martini, Maricela Ayala Martínez, Sergio Soto Simental, Rosa Hayde Alfaro Rodríguez, Juan Ocampo López, Raquel Cariño Cortés, Abigail Reyes Munguía","doi":"10.1089/jmf.2023.0153","DOIUrl":"10.1089/jmf.2023.0153","url":null,"abstract":"<p><p>Chronic noncommunicable diseases are a global health problem causing increased rates of mortality and sick leaves, which can be reduced by controlling dyslipidemia and hyperglycemia. Experimental and clinical studies have demonstrated the antidiabetic, lipid-lowering, antiobesogenic, anti-inflammatory, and antihypertensive properties of cinnamon; therefore, its use in yogurt can help reverse the effects of these diseases. Our study aims to evaluate the effect of a microencapsulated aqueous extract of cinnamon (<i>Cinnamomum zeylanicum</i>) (MCE Cz) incorporated in a yogurt drink on metabolic syndrome (MS) in a rabbit (<i>Oryctolagus cuniculus</i>). Physicochemical, microbiological, and proximal chemical characterization; total phenol, flavonoid, and 2,2-diphenyl-1-picrylhydrazil activity quantification; intestinal bioaccessibility; sensory analysis; MS induction through diet; and treatment with 5, 10, and 20 mg/kg of flavonoids contained in the MCE Cz were performed to help evaluate morphological, biochemical, and lipid peroxidation measurements in the liver and heart. The results show that the addition of MCE Cz in the yogurt modified the yogurt texture, increased its adhesiveness and firmness, and imparted a characteristic cinnamon color and biological value by providing intestinally bioaccessible antioxidants with antioxidant potential by reducing lipoperoxidation in the liver and heart after treatment. MCE Cz reduced the weight of the animals by up to 38.5% and the abdominal circumference by 29%. Biochemically, it decreased glucose levels by 24.38%, total cholesterol levels by 69.2%, triglyceride levels by 72.69%, and low-density lipoprotein levels by 89.25%; it increased high-density lipoprotein levels by 67.08%. Therefore, adding MCE Cz in doses of 5 and 10 mg of flavonoids in drinkable yogurt can be an alternative to preparing functional foods with physicochemical attributes and biological properties that can be consumed at all stages of life without undesirable effects. Moreover, it can act as a potential adjuvant in the treatment of comorbidities related to MS.</p>","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":"758-774"},"PeriodicalIF":1.7,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141442877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immune Boosting Effect of <i>Limosilactobacillus Reuteri</i> in Immunocompetent C57BL/6J Mice.","authors":"Hyunna Jung, Hwan Hee Lee, Hyojeung Kang, Hyosun Cho","doi":"10.1089/jmf.2024.k.0085","DOIUrl":"10.1089/jmf.2024.k.0085","url":null,"abstract":"<p><p>Probiotics are well-known to be directly or indirectly involved in the host immune system. In this study, we analyzed the immune-boosting effects of lactic acid bacteria, including <i>Limosilactobacillus</i> and <i>Lactococcus</i>, in immunocompetent C57BL/6J mice. Three different lactic acid bacteria strains were orally administered to C57BL/6J mice for 8 weeks. Then, liver, spleen, and whole blood were harvested after sacrificing the animals. There were no significant changes in whole-body weight, weight of organs, or complete blood cell count by oral administration of lactic acid bacteria. The frequencies of CD3⁺, CD4⁺, and CD8⁺ T cells were significantly increased in the <i>Limosilactobacillus reuteri</i> MG5462 group compared to control. The frequency of NK1.1⁺ cells was significantly increased in the <i>Lactococcus lactis</i> MG5474 group compared to control. On the other hand, splenocyte proliferations and natural killer cytotoxicity did not differ between groups. In addition, the MG5462 group had a significant increase in the production of TNF-α compared to the control, which is consistent with the upregulation of T cells in the MG5462 group. Therefore, <i>Limosilactobacillus reuteri</i> could be a functional food additive to boost immunity by positively affecting T cell populations.</p>","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":"713-719"},"PeriodicalIF":1.7,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141450699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rapid Mold Detection in Chinese Herbal Medicine Using Enhanced Deep Learning Technology.","authors":"Ting Zhu, Xincan Wu, Ling Ma, Yadian Zeng, Junbo Lian, Jiapeng Liu, Xinnan Chen, Lei Zhong, Jingnan Chang, Guohua Hui","doi":"10.1089/jmf.2024.k.0004","DOIUrl":"10.1089/jmf.2024.k.0004","url":null,"abstract":"<p><p>Mold contamination poses a significant challenge in the processing and storage of Chinese herbal medicines (CHM), leading to quality degradation and reduced efficacy. To address this issue, we propose a rapid and accurate detection method for molds in CHM, with a specific focus on <i>Atractylodes macrocephala</i>, using electronic nose (e-nose) technology. The proposed method introduces an eccentric temporal convolutional network (ETCN) model, which effectively captures temporal and spatial information from the e-nose data, enabling efficient and precise mold detection in CHM. In our approach, we employ the stochastic resonance (SR) technique to eliminate noise from the raw e-nose data. By comprehensively analyzing data from eight sensors, the SR-enhanced ETCN (SR-ETCN) method achieves an impressive accuracy of 94.3%, outperforming seven other comparative models that use only the response time of 7.0 seconds before the rise phase. The experimental results showcase the ETCN model's accuracy and efficiency, providing a reliable solution for mold detection in Chinese herbal medicine. This study contributes significantly to expediting the assessment of herbal medicine quality, thereby helping to ensure the safety and efficacy of traditional medicinal practices.</p>","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":"797-806"},"PeriodicalIF":1.7,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141450700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Primary Mechanisms of Drug-Food Homologous Traditional Chinese Medicine Polysaccharides in the Prevention and Treatment of Diabetes.","authors":"Mengjie Wang, Yudong Li, Siye Yang, Ping Wei","doi":"10.1089/jmf.2023.k.0093","DOIUrl":"10.1089/jmf.2023.k.0093","url":null,"abstract":"<p><p>Diabetes mellitus is a metabolic disease associated with hyperglycemia caused by insufficient insulin secretion or insulin resistance. Early symptoms are related to an abnormal increase in water intake, food intake, and urination. In Chinese medicine, diabetes mellitus is categorized as a \"thirst-quenching\" condition. Currently, the clinical treatment of diabetes mellitus relies mainly on Western medications, which often target the symptoms rather than alter the cause of the disease, and can cause certain side effects and drug resistance. In comparison, the polysaccharides of Chinese medicines from the same source of food and medicine have become an emerging choice for the prevention and treatment of diabetes due to their wide sources, high safety, and low side effects. To reveal the mechanisms of the polysaccharides of traditional Chinese medicine (TCM) in the prevention and treatment of diabetes mellitus, the CiteSpace visualization software was used to conduct extensive literature searches through Chinese and international databases, such as PubMed, Medline, and China National Knowledge Infrastructure. Through literature volume analysis, keyword co-occurrence, cluster analysis, and trend highlighting, we found that the main mechanisms of TCM polysaccharides in the prevention and treatment of diabetes include regulating intestinal flora, improving insulin resistance, alleviating oxidative stress, adjusting lipid metabolism imbalance, and inhibiting inflammatory responses. Furthermore, this study systematically summarizes the mechanism of \"using sugar to reduce sugar\" to provide innovative ideas for the development of health products for the treatment of diabetes using the polysaccharides of Chinese medicinal herbs.</p>","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":"693-703"},"PeriodicalIF":1.7,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141076016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diet Based on <i>Pereskia aculeata</i> Miller Flour Increases Muscle Volume and Modulates the Expression of Myokines in Mice Subjected to Resistance Training.","authors":"Simon Calvacante Silva Damasceno, Eliezer Francisco Rocha, Sérgio Avelino Mota Nobre, Bruna Viana Caldas, Mateus Ferreira Mendes, Elizabethe Adriana Esteves, Alfredo Maurício Batista de Paula, Sérgio Henrique Sousa Santos, João Marcus Oliveira Andrade","doi":"10.1089/jmf.2023.0134","DOIUrl":"10.1089/jmf.2023.0134","url":null,"abstract":"<p><p>The study aimed to evaluate the effects of <i>Pereskia aculeata</i> Miller (ora-pro-nobis [OPN]) flour on body and biochemical parameters, thermogenic activity, and molecular expression of markers in the muscle tissue of mice subjected to resistance training (RT). Twelve mice were randomly assigned to two groups (n=6 animals/group): G1: control (Control) fed a standard diet + RT and G2: experimental (OPN) fed a diet based on OPN flour + RT. The RT consisted of a 6-week program using a vertical ladder combined with a fixed weight attached to the animal. Several parameters were measured, including assessment of body composition, biochemical markers, thermogenic activity, and molecular (mRNA expression of interleukin (IL)-6, fibronectin type III domain-containing protein 5 (FNDC5), peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α), nuclear respiratory factor 1 (NRF1), and mitochondrial transcription factor A (TFAM). The OPN group exhibited a decrease in body weight and visceral adiposity, higher energy expenditure, and lipid oxidation rate. In addition, it was observed an increase in muscle volume and in mRNA expression levels of IL-6, FNDC5, PGC-1α, and TFAM. These findings suggest that OPN flour could be a nutritional option to enhance performance in RT.</p>","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":"749-757"},"PeriodicalIF":1.7,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141626939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}