Hypoglycemic Activity of the Hydroalcoholic Extract of Porophyllum ruderale in CD1 Mice.

Abstract

Diabetes, considered one of the main causes of death in the Mexican population, is a chronic disease caused by alterations in the synthesis of pancreatic insulin or because it is not used effectively by the body. Insufficient action of insulin causes hyperglycemia, which, if not controlled, causes damage to blood capillaries and nerve endings over time, affecting the functioning of various organs and systems. As mentioned above, controlling glucose levels in the population suffering from chronic diseases becomes an essential part of their treatment. The aim of this study was to evaluate the hypoglycemic effect of a hydroalcoholic extract of the aerial parts of Porophyllum ruderale (HEPr). A glucose tolerance curve was developed by monitoring at different times (0-120 min) glucose levels in blood samples taken from an apical tail slice of CD1 mice. HEPr showed a significant effect from baseline on basal glucose levels (114.33 ± 14.74 mg/dL) compared with the control group (60.33 ± 4.16 mg/dL) and the metformin-treated group (129 ± 13 mg/dL). In addition, the values at the end of the tolerance curve (120 min) showed a significant decrease in the study group (66 ± 10.39 mg/dL) compared with the metformin-treated group (108.67 ± 4.50 mg/dL). This effect can be attributed to the presence of chlorogenic acid, cryptochlorogenic acid, ferulic acid, quercetin, and kaempferol 3-O-glucosides in HEPr. In conclusion, P. ruderale constitutes an important source of compounds for use as an adjuvant treatment for the control of hypoglycemia in different chronic diseases.