Journal of medicinal food最新文献

{"title":"<i>Abelmoschus manihot</i> Flower Extract Retards Platelet-Derived Growth Factor-BB-Stimulated Proliferation and Migration in Vascular Smooth Muscle Cells by Inhibiting the MAPK/NF-κB Pathway and Matrix Metalloproteinase Expressions.","authors":"Chin-Feng Hsuan, Yi-Ting Kuo, Tzu-Hsien Chang, Ya-Ling Chen, Hsin-Ya Houng, Natasha Chang, Sabrina Chang, Chi-Chang Chang, Jer-Yiing Houng","doi":"10.1089/jmf.2024.k.0263","DOIUrl":"https://doi.org/10.1089/jmf.2024.k.0263","url":null,"abstract":"<p><p>Vascular smooth muscle cells (VSMCs) are vital to the structure of blood vessel walls. Under abnormal vascular conditions, VSMCs undergo a phenotypic transformation, leading to enhanced cell proliferation, migration, and matrix synthesis. This contributes to the development of vascular diseases such as atherosclerosis, arteriosclerosis, and restenosis. During this process, platelet-derived growth factor (PDGF)-BB is a key inducer of the VSMC phenotypic transformation. <i>Abelmoschus manihot</i> (L.) Medic flower (AMf) is known for its rich nutritional value and traditional medicinal uses. Its extract has been clinically used to treat kidney diseases, but its impact on VSMCs has not been documented. This study explored the inhibitory effects of AMf ethanol extract (AME), hot water extract (AMW), and supercritical CO₂ extract (AMS), and their five indicator components (rutin, quercetin, isoquercitrin, myricetin, and hyperoside) on PDGF-BB-stimulated proliferation and migration using a rat aortic smooth muscle cell (RASMC) model. Both AME and AMS showed a significant dose-dependent inhibition of PDGF-BB-induced RASMC proliferation and migration, with AME being more effective than AMS. In contrast, AMW had no effect. The five indicator compounds also showed excellent inhibitory effects. AME treatment effectively reduced the phosphorylation of JNK, ERK, p38, and NF-κB, and downregulated the expressions of the migration-promoting factors <i>MMP-2</i> and <i>MMP-9</i> in PDGF-BB-stimulated RASMCs. These findings suggest that AME protects VSMCs by regulating the phosphorylation of the MAPK/NF-κB pathway and suppressing MMP expression. Consequently, AME may help prevent or slow the progression of vascular diseases.</p>","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144078456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>Humulus japonicus</i> Enhances Bone Growth and Microarchitecture in Rats: Potential Involvement of IGF-1 Signaling.","authors":"Seong-Hoo Park, Jeongjin Park, Jung-Yoon Yoo, Hong-Sik Kim, Minhee Lee, Ok-Kyung Kim","doi":"10.1089/jmf.2025.k.0002","DOIUrl":"https://doi.org/10.1089/jmf.2025.k.0002","url":null,"abstract":"<p><p>This study investigated the effects of <i>Humulus japonicus</i> extract supplementation on bone growth and microstructural properties in male and female rats, with a particular focus on the JAK2/STAT5/IGF-1 signaling pathway. Three-week-old Sprague-Dawley rats were assigned to different groups receiving a normal diet (ND), growth hormone (GH), or varying doses of <i>H. japonicus</i> extract: low (L; 73 mg/kg body weight [bw]/day), medium (M; 146 mg/kg bw/day), and high (H; 292 mg/kg bw/day) for four weeks. The results demonstrated that the H group exhibited significant increases in femur and tibia lengths, trabecular and cortical bone mineral density, and growth plate thickness compared with the ND group. Furthermore, the H group demonstrated elevated serum and hepatic IGF-1 and IGFBP-3 levels, as well as enhanced phosphorylation of JAK2 and STAT5. The findings suggest that <i>H. japonicus</i> supplementation promotes longitudinal bone growth by stimulating growth plate activity and modulating the JAK2/STAT5-IGF-1 signaling pathway. This research indicates that <i>H. japonicus</i> extract could potentially be used as a natural therapeutic agent to support skeletal development and maintain bone health.</p>","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144078457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Supplementation Containing Bromelain on the Side Effects of Oncological Treatment: Systematic Review.","authors":"Irislene Costa Pereira, Raquel Barros Passos, Camila de Meneses Caetano Viana, Isabele Frazão Mascarenhas, Glauto Tuquarre de Melo Nascimento, Felipe Cavalcanti Carneiro da Silva, João Marcelo de Castro E Sousa, Francisco Leonardo Torres-Leal","doi":"10.1089/jmf.2023.0027","DOIUrl":"https://doi.org/10.1089/jmf.2023.0027","url":null,"abstract":"<p><p>Systemic therapies for the treatment of cancer collaborate to reduce cancer progression and have been used for decades. However, despite the clinical benefits, its long-term use is associated with toxicity, promoting important side effects that can compromise the quality of life. Enzyme supplementation has been pointed out as a therapeutic potential in several diseases. Bromelain is an enzyme complex that regulates pathways associated with inflammation. This review aims to evaluate the use of bromelain-containing supplements to improve the side effects of cancer treatment. This systematic review was developed in PubMed, Web of Science, and Cochrane Library, using the terms: Cancer AND Bromelain. 239 studies were retrieved, and only three met our objective. In general, it was possible to observe that supplementation was able to reduce side effects of adjuvant hormone therapy and chemotherapy, such as mucosal dryness, arthralgia, and peripheral neuropathy induced by chemotherapy.</p>","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144078473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Combined Turmeric and Allspice Supplement Improves Metabolic Health in Obese Rats by Reducing Carbohydrate and Lipid Absorption.","authors":"Jazel Barragan-Zuñiga, Mayra Denise Herrera, Luis E Simental-Mendía, Alejandro Zamilpa, Dulce Lourdes Morales-Ferra, Gerardo Martínez-Aguilar, José Salas-Pacheco, Claudia I Gamboa-Gómez","doi":"10.1089/jmf.2024.0024","DOIUrl":"https://doi.org/10.1089/jmf.2024.0024","url":null,"abstract":"<p><p>The objective of this study is to assess the impact of a combined turmeric (<i>Curcuma longa</i> L.) and allspice (<i>Pimenta dioica</i> L. Merril) supplement (TAS), on obesity, hypertriglyceridemia, hyperglycemia, and insulin resistance through inhibition of carbohydrate and lipid absorption. In vitro assessments demonstrated that TAS inhibits key enzymes implicated in the carbohydrate and lipid absorption. Oral starch and lipid tolerance tests showed that combined supplement reduced lipid (∼47% TAS) and carbohydrate absorption (∼33%) compared to the negative control. In a 36-week diet-induced obesity model, intervention with TAS was found that reduced body weight gain (∼18%), lower triglycerides (∼35%), and fasting glucose levels (∼14%) compared to obese control. Furthermore, TAS-treated rats showed reduced oral glucose tolerance test values (∼25%), insulin levels (∼14%), and insulin resistance (∼14%). Our results suggest that TAS enhances carbohydrate and lipid absorption while effectively improving hypertriglyceridemia, hyperglycemia, and insulin resistance in obese rats.</p>","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143996741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Randomized Placebo Controlled Clinical Study of Dill (<i>Anethum Graveolens L.</i>) in Thyroiditis and Nodular Goiter Patients.","authors":"Sabahattin Destek, İlker Demirbolat, Ayşegül Yabacı, Murat Kalemoglu, Murat Kartal, Emine Yeliz Ersoy, Vahit Onur Gul, Zulal Kayıran, Mustafa Erhan Aysan","doi":"10.1089/jmf.2024.0263","DOIUrl":"https://doi.org/10.1089/jmf.2024.0263","url":null,"abstract":"<p><p>Thyroid nodules are common and affect half of the general population by the age of 60 years. The cause is believed to be due to hypothyroidism, mutational changes, and autoimmunity leading to thyroid carcinoma. Dill, a traditional herbal remedy, has been used to treat thyroid dysfunctions such as hyperthyroidism and hypothyroidism. This study evaluates the effects of dill (<i>Anethum graveolens L.</i>) on patients with thyroiditis and nodular goiter. A study was conducted on patients with benign thyroid nodules. They were divided into two groups; placebo (=35) and dill group (<i>n</i> = 33). Dried and ground dill was put into hydroxypropyl methylcellulose capsules and patients were given three capsules per day for 90 days. Various tests were conducted at the beginning and end of the study, including thyroid stimulating hormone (TSH), free triiodothyronine (FT3), free thyroxine (FT4), anti-thyroid peroxidase (anti-TPO), anti-thyroglobulin (anti-Tg), and C-reactive protein (CRP) analysis, and thyroid nodule dimensions were measured by ultrasound. Statistical analysis was performed. After 90 days of treatment with dill extract, patients showed significant reductions in TSH, FT4, anti-TPO, and CRP levels, as well as a decrease in thyroid nodule sizes as demonstrated by ultrasonography. The dill-treated group had significantly decreased TSH (<i>P</i> = .020), FT4 (<i>P</i> = .001), anti-TPO (<i>P</i> = .004), CRP (<i>P</i> = .003) levels, and nodule sizes (<i>P</i> = .001) at the beginning and end of the study. Compared to the control group, the dill group had significantly decreased TSH (<i>P</i> = .009), fT4 (<i>P</i> < .001), anti-TPO (<i>P</i> = .001), CRP (<i>P</i> < .001) levels and nodule sizes (<i>P</i> < .001), which reached normal values. <i>A. graveolens</i> suppressed inflammation of the thyroid gland, reduced nodule size, and normalized TSH levels. Dill supplementation should be recommended for the treatment of thyroid nodules in selected patients.</p>","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143968034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Therapeutic Effects of Edible Desert Truffle Specie (<i>Tirmania nivea</i>) on Hepatogastric Toxicity Induced by Aspirin Treatment in Rats.","authors":"Dorra Ben Said, Ridha Ben Ali, Ezzedine Nouiri, Mohamed Bassem Hammami, Michelle-Véronique Elmay, Sihem El Aidli","doi":"10.1089/jmf.2023.0202","DOIUrl":"https://doi.org/10.1089/jmf.2023.0202","url":null,"abstract":"<p><p>Edible mushrooms (<i>Tirmania nivea</i>: Desert truffle specie) are a nutrient-dense source of flavonoids, proteins, fatty acids, minerals, and vitamins. The current study aimed to evaluate the curative effect of an aqueous extract of <i>T. nivea</i> ascocarps against aspirin-induced gastric, liver, and kidney injuries in rats. Hepatogastric disorders induced by aspirin at a dose of 10 mg/kg body weight (BW) treatment in rats and treated with aqueous extract of <i>T. nivea</i> at different doses 25, 50, and 100 mg/kg BW). <i>T. nivea</i> aqueous extract liquid chromatography-mass spectroscopy analysis showed several actives biomolecules such as quinic acid, syringic acid, O-coumaric acid, chlorogenic acid, caffeic acid, luteolin-7-O-glucoside, 4-O-caffeoylquinic acid, and vitamin C. The 1,1-diphenyl-2-picrylhydrazyl radical-scavenging activity revealed significant antioxidant activity (EC₅₀% = 0.6 mg/mL). Aspirin administration caused severe injuries with linear hemorrhagic lesions. The treatment with <i>T. nivea</i> extract ameliorates gastric mucosal structure. The aspirin treatment caused significant increase of alanine aminotransferase and aspartate aminotransferase activities. In curative objective, <i>T. nivea</i> extract significantly corrected the disturbance of liver parameters. Rats given aspirin showed altered liver architecture, apoptosis, and inflammation; in contrast, sections of liver tissue in the rats treated with <i>T. nivea</i> extract at 25 mg/(kg·day) after aspirin administration showed normal liver architecture. A normal architecture was restored once the treatment dose was increased to 50 mg/kg. After 14 days of treatment with 100 mg/(kg·day) of <i>T. nivea</i> extract, aspirin disruptions completely collapse with development of steatosis. On contrary, one week of rat's treatment by aspirin succeed by 2 weeks without any treatment, the histological examination of the kidney showed a dilated capillary and altered Bellini tubes. Normal renal architecture was observed at a dosage of 25 mg/(kg·day) of <i>T. nivea</i>. Extract from <i>T. nivea</i> restored the renal disturbances caused by aspirin.</p>","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143996088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In Silico and In Vivo Biological Evaluation of Extracts from Tunisian Desert Truffles (<i>Tirmania nivea</i> and <i>Terfezia boudieri</i>) on Scopolamine-Induced Memory Impairment in Mice.","authors":"Mohamed Ali Smach, Rihab Hammami, Amira Zarrouk, Jawhar Hafsa, Bassem Charfeddine, Khalifa Limem, Ayda Khadhri","doi":"10.1089/jmf.2023.0178","DOIUrl":"https://doi.org/10.1089/jmf.2023.0178","url":null,"abstract":"<p><p>The present work focuses on studying the effectiveness of truffle extract administration to enhance memory functions in a scopolamine-induced amnesia mice model. Major phytochemical constituents, gallic acid and myricetin, underwent <i>in silico</i> studies using Autodock Vina and Discovery Studio visualizer software. Male mice were pretreated orally with either truffle extracts (400 mg/kg) or donepezil (3 mg/kg) for 21 days. Dementia was induced in mice by scopolamine (1 mg/kg) after 19 days of pretreatment and until day 28. The mice were divided into five experimental groups: (1) control; (2) model; (3) donepezil (1 mg/kg); (4) <i>Tirmania nivea</i> (400 mg/kg); and (5) <i>Terfezia boudieri</i> (400 mg/kg). Mice were subsequently subjected to a battery of behavioral tests, including an open field locomotor activity assay, and the Morris water maze (MWM) test. Biochemical, histopathological analyses and molecular docking were performed. Chronic Scopolamine administration decreased learning and memory enhancement during the MWM test. A significant increase in time to find the hidden platform and escape was observed. Scopolamine increases acetylcholinesterase (AChE) activity and oxidative stress. Conversely, treatment with the <i>T. nivea</i> and <i>T. boudieri</i> extracts (400 mg/kg orally administered) increased the memory of mice in the MWM task and suppressed scopolamine-induced oxidative damage. The memory enhancement effect was observed by the best docking scores of gallic acid and myricetin against AChE. This study reveals truffle's ameliorative effect on scopolamine-induced dementia in mice, possibly mediated by modulation of cholinergic activity and antioxidant activity. The docking of two major compounds, gallic acid and myricetin, predicted their potential as memory enhancers.</p>","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144015824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hypoglycemic Effect of Black Tea and Its Mechanism: Regulation of Glycometabolism and Intestinal Flora.","authors":"Fanglan Li, Hui Zhou, Jiangxiong Zhu, Xinlin Wei, Yuanfeng Wang","doi":"10.1089/jmf.2024.k.0251","DOIUrl":"10.1089/jmf.2024.k.0251","url":null,"abstract":"<p><p>This study aimed to investigate the hypoglycemic effects of different concentrations of black tea (BT) extracts and their underlying mechanisms in type 2 diabetic (T2DM) mice. Results indicated that BT extracts significantly mitigated weight loss, improved glucose and insulin tolerance, and modulated cytokine levels related to glucose and lipid metabolism in T2DM mice. Moreover, BT extracts ameliorated liver and pancreas damage resulting from high-sugar/high-fat diets and insulin resistance. Among the tested concentrations, low-concentration BT (BT-L) extract exhibited the most potent hypoglycemic ability. Furthermore, BT-L restored pancreatic function in hyperglycemic mice via activating the glucagon-like peptide-1 receptor-protein kinase A-pancreatic and duodenal homeobox-1-glucokinase cascade pathway. In terms of intestinal homeostasis, all BT-treated groups adjusted the gut microbiota structure by regulating the distribution and diversity of gut microbiota in T2DM mice. Among them, BT-L intervention specifically and significantly increased the levels of probiotic <i>Bifidobacterium</i> in the intestine of T2DM mice. Furthermore, BT-L intervention effectively promoted the synthesis of streptomycin by gut microbiota, thereby exerting anti-inflammatory effect. Comprehensively, the hypoglycemic effect of BT cannot show an absolute concentration-dependent relationship. Our findings highlight the potential of BT as an effective blood glucose regulator and provide valuable insights for BT-based functional food development.</p>","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":"435-447"},"PeriodicalIF":1.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143573278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anti-Inflammatory Effects of <i>Huberantha luensis and Ancistrocladus tectorius</i> Extracts Through Inhibition of Nuclear Factor-κB and Mitogen-Activated Protein Kinase Pathways.","authors":"Seong Ju Oh, Young Sun Jang, Eun-Ryoung Kim, Jun Il Kim, HyeBin Kim, YoungEun Kim, Chae Won Park, Hi Su Jang, The Bach Tran, Thu Thuy Nguyen, In-Kee Hong","doi":"10.1089/jmf.2024.k.0276","DOIUrl":"https://doi.org/10.1089/jmf.2024.k.0276","url":null,"abstract":"<p><p>Inflammation is a crucial response to harmful stimuli, but its chronic activation contributes to various diseases, including inflammatory bowel disease, osteoarthritis, and neurological disorders. While nonsteroidal anti-inflammatory drugs are widely used as anti-inflammation drugs, their extended usage often results in severe side effects, emphasizing the need for safer alternatives. Therefore, it is of the greatest importance to identify and discover new anti-inflammatory agents that exhibit a reduced incidence of adverse side effects. This study investigates the anti-inflammatory potential of methanol extracts from eight native Vietnamese plant species. These extracts were screened for their ability to inhibit nitric oxide production and pro-inflammatory cytokine expression in lipopolysaccharides-stimulated RAW264.7 macrophages. Among the tested extracts, those derived from <i>Huberantha luensis</i> (Pierre) Chaowasku and <i>Ancistrocladus tectorius</i> (Lour.) Merr. demonstrated notable reductions in NO, TNF-α, interleukin (IL)-1β, and IL-6 levels. Further analysis revealed that these extracts are abundant in polyphenols and flavonoids, compounds recognized for their anti-inflammatory effects. Furthermore, these extracts exerted their effects by inhibiting the kappa-light-chain-enhancer of activated B cells and mitogen-activated protein kinase signaling pathways, as evidenced by reduced phosphorylation of the proteins. These results suggest that the methanol extracts obtained from <i>H. luensis</i> and <i>A. tectorius</i> possess considerable potential in paving the way towards the innovative development of new therapeutic approaches aimed at alleviating chronic inflammation.</p>","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":"28 5","pages":"448-454"},"PeriodicalIF":1.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144015993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pharmacological Evaluation of Respiratory Safety Following a Single Intravenous Administration of Theophylline in Sprague-Dawley Rats.","authors":"Sung-Hyun Cho, Minseo Cho, Miae Doo, Jung-Heun Ha","doi":"10.1089/jmf.2024.k.0275","DOIUrl":"10.1089/jmf.2024.k.0275","url":null,"abstract":"<p><p>Drinking tea is an important cultural and sensory activity in modern society. However, tea consumption may influence biological functions because of its high polyphenol and methylxanthine content. Theophylline is a methylxanthine that plays a significant role in respiratory physiology and is used clinically as a bronchodilator. In this study, we assessed the pharmacological safety of theophylline by investigating its effects on the respiratory responses of experimental rodents. Six-week-old male Sprague-Dawley rats were intravenously administered 0, 2.5, 5, or 10 mg/kg theophylline. After systemic theophylline exposure, the respiratory rate, tidal volume, and minute volume were monitored and statistically analyzed. There was a significant increase in respiratory rate and minute volume with no change in tidal volume at theophylline doses of >5 mg/kg. Changes in respiratory rate and minute volume peaked at 0.25 h after exposure; the respiratory rate increased by 58.2% and 88.9%, and the minute volume increased by 50.5% and 72.8% with the 5 and 10 mg/kg doses, respectively, compared with the vehicle control. These results provide fundamental scientific data that can be used in clinical applications.</p>","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":"508-512"},"PeriodicalIF":1.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143189318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}