Journal of medicinal food最新文献

{"title":"<i>Fridericia chica</i> (Bonpl.) L.G. Lohmann: An Overview of Medicinal Plant Studies.","authors":"Vitória Ribeiro Garcia de Figueiredo-Muniz, Ana Paula Biz, Ilza Maria de Oliveira Sousa, Luciana Igarashi Mafra, Mary Ann Foglio, Alvaro Luiz Mathias, Marcos Rogério Mafra","doi":"10.1089/jmf.2023.0286","DOIUrl":"https://doi.org/10.1089/jmf.2023.0286","url":null,"abstract":"<p><p><i>Fridericia chica</i> (Bonpl.) L.G. Lohmann (synonym <i>Arrabidaea chica</i> Verlot) has aroused the medical interest of researchers in recent years. The leaves of <i>F. chica</i> are used in folk medicine as anti-inflammatory, antimicrobial, for wound healing of skin or mucous membranes, ulcers, intestinal colic, diarrhea, and blood disorders such as hemorrhage and anemia. Herein, we present a review of the scientific production on <i>F. chica</i> employing the SciVerse Scopus database to elucidate the research trends and perspectives in this field of science. To identify relevant publications, 95 research articles and 10 reviews were selected, totaling 105 publications, of which Brazilian researchers published 91. The research areas most covered in the publications were Pharmacology, Agricultural and Biological Sciences, with the keywords highlighting flavonoids chemical class as the most cited. The data collected provides an overview of the status of this species, with scarce research reports on the application of <i>F. chica</i> products. Furthermore, <i>F. chica</i> is also unexplored in Food Science and Technology, demonstrating new research opportunities.</p>","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144234367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and Safety of <i>Saururus chinensis</i> Extract (LHF618) for Treating Allergic Rhinitis: A Randomized, Double-Blind, Placebo-Controlled, Multicenter Clinical Study.","authors":"Yoonhee Lee, Jae Kyung Lee, Juyeon Park, Nahyeon Kim, Hye-Ryun Kang, Yongbum Kwon","doi":"10.1089/jmf.2025.k.0008","DOIUrl":"https://doi.org/10.1089/jmf.2025.k.0008","url":null,"abstract":"<p><p>Allergic rhinitis (AR) has become a global health concern due to its increasing prevalence, significantly impacting the quality of life. Traditional treatment options often provide only temporary symptom relief and may cause adverse effects, leading to the exploration of alternative therapies. This study evaluates the effectiveness and safety of standardized <i>Saururus chinensis</i> extract (LHF618) for alleviating symptoms of AR. Over a 4-week period, patients receiving LHF618 showed significant reductions in total nasal symptom scores, particularly for symptoms such as nasal itching, sneezing, and congestion, compared with the control group. Additionally, LHF618 led to a marked improvement in rhinitis control assessment test scores and a significant reduction in specific immunoglobulin E levels related to dust mite allergens. Importantly, no significant adverse effects were observed, indicating that LHF618 is a well-tolerated and safe option. These findings suggest LHF618 could be a promising natural alternative for managing AR, especially in cases related to dust mite allergies.</p>","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144225733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of Metabolomics and Microbiome Analysis for Revealing the Endogenous Mechanism of Baizhu Xiaozhong San in Postpartum Rats with Spleen-qi Deficiency.","authors":"Di Cao, Jie Chen, Yanhua Zhang, Hao Rui, Ke Guang, Le Zhang, Ruyi Wu, Sihui Nian, Xiaojun Song","doi":"10.1089/jmf.2024.k.0233","DOIUrl":"10.1089/jmf.2024.k.0233","url":null,"abstract":"<p><p>Postpartum women are in a state of physical weakness and suffering from fatigue. Metabolic disturbances in the postpartum period may lead to an increased prevalence of postpartum depression, hemorrhage, and obesity, underscoring the importance of prioritizing maternal health. The combination (Baizhu Xiaozhong San, BZXZS) of charred <i>Atractylodis macrocephalae</i> Koidz. (Baizhu, BZ) and charred <i>Fructus Aurantii</i> Immaturus (Zhishi, ZS) has primary applications for invigorating the spleen and promoting diuresis. This study utilized serum/spleen metabolomics in conjunction with 16S rDNA sequencing analysis to investigate the endogenous metabolic alterations and intestinal homeostasis in postpartum rats exhibiting spleen-deficiency syndrome (SDS). The pathological symptoms of postpartum SDS rats in the administration groups were gradually restored, in particular, the symptoms of the BZXZS-H group rats improved significantly. As a result, 32 differential metabolites and 7 correlated metabolic pathways (impact value > 0.1) demonstrated the improvement effect of BZXZS on postpartum SDS rats mostly focusing on disorders of energy, carbohydrate, and lipid metabolism. 16S rDNA gene sequencing indicated that BZXZS had a significantly better regulatory effect on <i>Lactobacillus faecis</i>. The findings suggest that BZXZS exerts a positive impact on the intestinal health and the immune system of postpartum SDS rats through an intricate cascade of interactions with various targets.</p>","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":"584-594"},"PeriodicalIF":1.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143988668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of Prebiotics and Probiotics (Synbiotics) on Weight Loss and Biochemical Parameters in Obese Individuals.","authors":"Nazan Erenoglu Son, Eren Son","doi":"10.1089/jmf.2023.0233","DOIUrl":"10.1089/jmf.2023.0233","url":null,"abstract":"<p><p>This study examined the effects of prebiotic and probiotic (synbiotic) supplementation on weight loss and biochemical parameters in treating obesity. The study was conducted with 110 participants in Eskisehir Anadolu Hospital, Turkiye, between February 15, 2019 and February 15, 2020. Individuals with obesity, who were following a weight loss diet, were randomly assigned to two groups. While one group (the control group) followed the diet only, the other group received synbiotic tablets in the morning and evening, in addition to the diet. Anthropometric values and biochemical parameters of the patients were measured at the beginning of the study and 3 months after. A significant decrease was found in weight, body mass index (BMI), and waist circumference values compared with baseline in both groups (<i>P</i>: .001; <i>P</i> < .05). A significant decrease was found in fasting blood sugar and HOMA-IR values compared with baseline in both groups. Furthermore, there was a significant increase in vitamin B12 and vitamin D values in the group receiving synbiotics compared with their baseline values. As a result of our study, both groups experienced similar weight loss and a decrease in BMI values. The vitamin B12 and vitamin D values of the group that took supplements increased significantly. The HOMA-IR values were significantly lower in both groups, albeit more in the synbiotic group. Changes in vitamin B12, vitamin D, and HOMA-IR values are extremely important for improving the health parameters in the long term.</p>","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":"568-573"},"PeriodicalIF":1.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143795719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>Humulus japonicus</i> Enhances Bone Growth and Microarchitecture in Rats: Potential Involvement of IGF-1 Signaling.","authors":"Seong-Hoo Park, Jeongjin Park, Jung-Yoon Yoo, Hong-Sik Kim, Minhee Lee, Ok-Kyung Kim","doi":"10.1089/jmf.2025.k.0002","DOIUrl":"10.1089/jmf.2025.k.0002","url":null,"abstract":"<p><p>This study investigated the effects of <i>Humulus japonicus</i> extract supplementation on bone growth and microstructural properties in male and female rats, with a particular focus on the JAK2/STAT5/IGF-1 signaling pathway. Three-week-old Sprague-Dawley rats were assigned to different groups receiving a normal diet (ND), growth hormone (GH), or varying doses of <i>H. japonicus</i> extract: low (L; 73 mg/kg body weight [bw]/day), medium (M; 146 mg/kg bw/day), and high (H; 292 mg/kg bw/day) for four weeks. The results demonstrated that the H group exhibited significant increases in femur and tibia lengths, trabecular and cortical bone mineral density, and growth plate thickness compared with the ND group. Furthermore, the H group demonstrated elevated serum and hepatic IGF-1 and IGFBP-3 levels, as well as enhanced phosphorylation of JAK2 and STAT5. The findings suggest that <i>H. japonicus</i> supplementation promotes longitudinal bone growth by stimulating growth plate activity and modulating the JAK2/STAT5-IGF-1 signaling pathway. This research indicates that <i>H. japonicus</i> extract could potentially be used as a natural therapeutic agent to support skeletal development and maintain bone health.</p>","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":"542-552"},"PeriodicalIF":1.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144078457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chemometric and Dereplication Analyses of the Anti-<i>Staphylococcus aureus</i> Strains Activity of <i>Salvia hispanica</i> L. Seeds.","authors":"Luis A Herbert-Doctor, Andrés Humberto Uc-Cachón, Angel Dzul-Beh, Avel A González-Sánchez, Jesús Alfredo Araujo-León, Gloria María Molina-Salinas, Hugo Pilotzi-Xahuentitla, Zhelmy Del Rocío Martín-Quintal, Rolffy Ortiz-Andrade","doi":"10.1089/jmf.2024.0241","DOIUrl":"10.1089/jmf.2024.0241","url":null,"abstract":"<p><p>Although the bactericidal activity of other <i>Salvia</i> spp. has been documented, research on <i>Salvia hispanica</i> seeds is sparse. This study examined the effects of <i>S. hispanica</i> seed extracts against drug-resistant <i>Staphylococcus aureus</i> reference strains and clinical isolates. Antibacterial effect was assessed using the minimal inhibitory concentration. Antibiofilm activity was evaluated using <i>S. aureus</i> ATCC 43300 and SAU-UIMY-31 strains, and antihemolytic effects were evaluated using <i>S. aureus</i> ATCC 29213 and SAU-UIMY-31. Biological effects and phytochemical profiles were analyzed through gas chromatography and mass spectrometry and chemometric tools. The nonpolar extract demonstrated antibiofilm activity with IC₅₀ values of 93.9 ± 5.4 µg/mL and 146.2 ± 2.4 µg/mL against <i>S. aureus</i> ATCC 43300 and SAU-UIMY-31, respectively. The median polar extract showed an IC₅₀ of 168.1 ± 13.9 µg/mL against <i>S. aureus</i> ATCC 43,300 and >250 µg/mL against SAU-UIMY-31. Antihemolysis IC₅₀ values for both extracts were 48.5 ± 3.3 and 52.9 ± 3.1 µg/mL against <i>S. aureus</i> ATCC 29213 and 58.0 ± 1.4 and 87.9 ± 2.4 µg/mL against SAU-UIMY-31, respectively. Chemometric analyses suggested that fatty acid methyl esters are potential contributors to biological activity. These findings provide a foundation for future studies on the use of <i>S. hispanica</i> seeds in antibacterial therapies.</p>","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":"615-624"},"PeriodicalIF":1.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144015991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epigallocatechin-3-Gallate and Glabridin Synergistically Inhibited Melanogenesis by Molecular Interaction and the MicroRNA-Microphthalmia-Related Transcription Factor Pathway.","authors":"Jingwu Song, Zhaowen Chen, Tongtong Li, Weijia Xu, Guan Feng, Jian Ge","doi":"10.1089/jmf.2024.k.0274","DOIUrl":"10.1089/jmf.2024.k.0274","url":null,"abstract":"<p><p>Epigallocatechin-3-gallate (EGCG) and glabridin (GLA) are two phytochemicals derived from homologous plants used for medicine and food that have demonstrated efficacy in inhibiting excessive production of melanin and promoting skin whitening properties. However, it is unknown whether EGCG and GLA can synergistically inhibit melanogenesis. The aim of this study was to explore the effects of the combination of EGCG and GLA on the expression and activity of microphthalmia-related transcription factor (MITF) and to reveal the mechanism of the synergistic treatment with EGCG and GLA on excessive melanin deposition. This study used B16F10 cells to screen for the synergistic effect on melanin deposition and determined the best ratio of EGCG and GLA. Dual-luciferase reported gene assays were used to explore whether GLA and EGCG could regulate the mRNA level of MITF. Molecular docking and molecular dynamics simulation were used to explain the synergistic interaction of EGCG and GLA with MITF, and then Masson-Fontana and hematoxylin-eosin were used to observe the skin changes of mice. The results showed that the combination of EGCG and GLA could synergistically regulate MITF and thus inhibit melanogenesis by modulating microRNA expression. EGCG and GLA were also able to synergistically interact with MITF to inhibit excessive melanogenesis. [Figure: see text].</p>","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":"553-567"},"PeriodicalIF":1.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144127934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oral Supplements and Photoprotection: A Systematic Review.","authors":"Nicole Natarelli, Shaliz Aflatooni, Kaylee Stankiewicz, Lilia Correa-Selm, Raja K Sivamani","doi":"10.1089/jmf.2024.0023","DOIUrl":"10.1089/jmf.2024.0023","url":null,"abstract":"<p><p>Photoprotective effects of various nutritional components and supplements have been demonstrated in animal and <i>in vitro</i> studies. The objective of this systematic review is to assess the photoprotective effects of various dietary supplements. A systematic review of studies assessing dietary supplements on photoprotective outcomes was performed. Human studies were retrieved from PubMed, Embase, and Cochrane in February 2023. Supplement keywords included \"dietary supplements,\" \"vitamins,\" \"minerals,\" \"carotenoids,\" \"lutein,\" \"isoflavones,\" \"polyphenols,\" \"<i>Polypodium leucotomos</i>,\" \"heliocare,\" \"herbal medicine,\" \"probiotics,\" \"prebiotics,\" \"astaxanthin,\" \"rosmarinic acid,\" \"botanical,\" and \"herb,\" and outcome keywords included \"photoprotection,\" \"ultraviolet rays,\" UVA,\" \"UVB,\" and \"blue light.\" A total of 47 studies were included in the systematic review. Studied supplements included carotenoids, polyphenols, <i>Polypodium leucotomos</i> (PL), melon concentrate, vitamins, coenzyme Q, squalene, and omega-3 and omega-6 fatty acids. Some studies evaluated mixed supplementation and incorporated other active ingredients such as selenium and probiotics. The greatest evidence of photoprotection exists for polyphenols, carotenoid-based, and PL supplementation. While flavanol supplementation exhibited dose-dependency, dose-dependency could not be consistently demonstrated for polyphenol supplementation. The weakest evidence exists for photoprotective effects of isolated vitamin or coenzyme Q supplementation. Dietary supplements may promote enhanced photoprotection, although current evidence is limited by small sample size and short duration. Supplementation with photoprotective active ingredients may be especially favorable for individuals with predisposed ultraviolet sensitivity, such as those with polymorphic light eruption. Future research is necessary to determine optimal dosing and supplementation duration for intended photoprotective outcomes.</p>","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":"519-541"},"PeriodicalIF":1.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142971281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Therapeutic Effects of Edible Desert Truffle Specie (<i>Tirmania nivea</i>) on Hepatogastric Toxicity Induced by Aspirin Treatment in Rats.","authors":"Dorra Ben Said, Ridha Ben Ali, Ezzedine Nouiri, Mohamed Bassem Hammami, Michelle-Véronique Elmay, Sihem El Aidli","doi":"10.1089/jmf.2023.0202","DOIUrl":"10.1089/jmf.2023.0202","url":null,"abstract":"<p><p>Edible mushrooms (<i>Tirmania nivea</i>: Desert truffle specie) are a nutrient-dense source of flavonoids, proteins, fatty acids, minerals, and vitamins. The current study aimed to evaluate the curative effect of an aqueous extract of <i>T. nivea</i> ascocarps against aspirin-induced gastric, liver, and kidney injuries in rats. Hepatogastric disorders induced by aspirin at a dose of 10 mg/kg body weight (BW) treatment in rats and treated with aqueous extract of <i>T. nivea</i> at different doses 25, 50, and 100 mg/kg BW). <i>T. nivea</i> aqueous extract liquid chromatography-mass spectroscopy analysis showed several actives biomolecules such as quinic acid, syringic acid, O-coumaric acid, chlorogenic acid, caffeic acid, luteolin-7-O-glucoside, 4-O-caffeoylquinic acid, and vitamin C. The 1,1-diphenyl-2-picrylhydrazyl radical-scavenging activity revealed significant antioxidant activity (EC₅₀% = 0.6 mg/mL). Aspirin administration caused severe injuries with linear hemorrhagic lesions. The treatment with <i>T. nivea</i> extract ameliorates gastric mucosal structure. The aspirin treatment caused significant increase of alanine aminotransferase and aspartate aminotransferase activities. In curative objective, <i>T. nivea</i> extract significantly corrected the disturbance of liver parameters. Rats given aspirin showed altered liver architecture, apoptosis, and inflammation; in contrast, sections of liver tissue in the rats treated with <i>T. nivea</i> extract at 25 mg/(kg·day) after aspirin administration showed normal liver architecture. A normal architecture was restored once the treatment dose was increased to 50 mg/kg. After 14 days of treatment with 100 mg/(kg·day) of <i>T. nivea</i> extract, aspirin disruptions completely collapse with development of steatosis. On contrary, one week of rat's treatment by aspirin succeed by 2 weeks without any treatment, the histological examination of the kidney showed a dilated capillary and altered Bellini tubes. Normal renal architecture was observed at a dosage of 25 mg/(kg·day) of <i>T. nivea</i>. Extract from <i>T. nivea</i> restored the renal disturbances caused by aspirin.</p>","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":"595-602"},"PeriodicalIF":1.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143996088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond Performance: Creatine Delays the Onset of Fatigue and Augments Muscle Regeneration in Doxorubicin-Induced Myotoxicity.","authors":"Salaheddin Sharif, Raquel Busekrus, Brandon Jones, David Hydock","doi":"10.1089/jmf.2022.0070","DOIUrl":"10.1089/jmf.2022.0070","url":null,"abstract":"<p><p>Doxorubicin (Dox) impairs myogenic regulatory factor (MRF) expression and induces myotoxicity, and previous studies showed that creatine (Cr) supplementation before Dox treatment prevents forelimb grip (FG) force reduction and alleviates fatigue. However, Cr supplementation's effects on MRFs with Dox treatment are not well known. The effects of Cr on skeletal muscle function and MRFs 1, 3, and 5 days following Dox treatment are investigated. Male rats were randomly assigned to the control saline group (Con+Sal), control doxorubicin group (Con+Dox), standard Cr diet (2% Cr for 4 weeks) doxorubicin group (Cr1+Dox), or Cr loading diet (4% Cr for 1 week followed by 2% Cr 3 weeks) doxorubicin group (Cr2+Dox). After 4 weeks of feeding, Dox groups received 15 mg/kg Dox and Sal received saline as a placebo. At 1, 3, and 5 days postinjection, FG force and <i>ex vivo</i> muscle function of the extensor digitorum longus (EDL) were measured. Myf-6, Myf-5, MyoD, and myogenin expression was analyzed using Western blotting. At 5 days postinjection, Con+Dox, Cr1+Dox, and Cr2+Dox groups had significantly lower FG force than Con+Sal (<i>P</i> < .05). EDL maximal twitch force of Con+Dox, Cr1+Dox, and Cr2+Dox groups was significantly lower than Con+Sal (<i>P</i> < .05) at 3 and 5 days postinjection. At 1 and 5 days postinjection, Cr alleviated Dox-induced fatigue in EDL muscle. At 1-day postinjection, Cr1+Dox, and Cr2+Dox had significantly higher Myf-6 and myogenin expression than the Con+Sal group, and Cr2+Dox group had significantly higher Myf-5 and MyoD compared with the Con+Sal group (<i>P</i> < .05). Cr supplementation attenuated fatigue and enhanced early muscle repair and regeneration in Dox-induced myotoxicity.</p>","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":"625-637"},"PeriodicalIF":1.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144127932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}