Journal of medicinal food最新文献

{"title":"<i>Schisandra Chinensis</i> Polysaccharide Ameliorates Renal Dysfunction by Inhibiting Inflammatory Reactions and Oxidative Stress in Diabetic Rats.","authors":"Chunmei Wang, Ting Li, Chengcheng Lin, Xudong Qiu, Wenyue Zhuang, He Li, Xingming Feng, Xingxu Du, Jinghui Sun","doi":"10.1089/jmf.2024.k.0285","DOIUrl":"https://doi.org/10.1089/jmf.2024.k.0285","url":null,"abstract":"<p><p><i>Schisandra chinensis</i> (<i>S. chinensis</i>) polysaccharide (SCP) is an active ingredient from <i>S. chinensis</i> used mainly for the treatment of diabetes, owing to its antioxidant, hypoglycemic, and lipidemic-modulating activities. A rat type II diabetes mellitus model was established by giving rats a high-fat diet and streptozotocin (STZ) to investigate the protective effect of SCP against renal injury in diabetic rats. It was found in this study that fasting blood glucose, serum lipids, serum creatinine, and blood urea nitrogen levels were decreased, the insulin sensitivity was increased, and pathological injuries of the kidney were alleviated in SCP-treated groups, indicating that SCP should have a protective effect against renal injury in diabetic rats. SCP treatment reduced serum C-reactive protein and inhibited the expression of nuclear factors-κB and related inflammatory factors in the renal tissue of diabetic rats. SCP treatment also regulated the expression of Nuclear factor (erythroid-derived 2) like-2, heme oxygenase-1, and kelch-like ECH-associated protein-1, reduced serum malondialdehyde content, and increased superoxide dismutase activity. Furthermore, SCP down-regulated the expression of fibronectin, α-SMA, transforming growth factor β1, and p-Smad3, up-regulated Smad7 expression, and mitigated the collagen fiber deposition in the renal interstitium in diabetic rats. It can be concluded that the mechanism of SCP in alleviating renal injury may be related to inhibiting inflammation, increasing antioxidant stress capacity, and improving renal fibrosis in diabetic rats.</p>","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143811559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of Prebiotics and Probiotics (Synbiotics) on Weight Loss and Biochemical Parameters in Obese Individuals.","authors":"Nazan Erenoglu Son, Eren Son","doi":"10.1089/jmf.2023.0233","DOIUrl":"https://doi.org/10.1089/jmf.2023.0233","url":null,"abstract":"<p><p>This study examined the effects of prebiotic and probiotic (synbiotic) supplementation on weight loss and biochemical parameters in treating obesity. The study was conducted with 110 participants in Eskisehir Anadolu Hospital, Turkiye, between February 15, 2019 and February 15, 2020. Individuals with obesity, who were following a weight loss diet, were randomly assigned to two groups. While one group (the control group) followed the diet only, the other group received synbiotic tablets in the morning and evening, in addition to the diet. Anthropometric values and biochemical parameters of the patients were measured at the beginning of the study and 3 months after. A significant decrease was found in weight, body mass index (BMI), and waist circumference values compared with baseline in both groups (<i>P</i>: .001; <i>P</i> < .05). A significant decrease was found in fasting blood sugar and HOMA-IR values compared with baseline in both groups. Furthermore, there was a significant increase in vitamin B12 and vitamin D values in the group receiving synbiotics compared with their baseline values. As a result of our study, both groups experienced similar weight loss and a decrease in BMI values. The vitamin B12 and vitamin D values of the group that took supplements increased significantly. The HOMA-IR values were significantly lower in both groups, albeit more in the synbiotic group. Changes in vitamin B12, vitamin D, and HOMA-IR values are extremely important for improving the health parameters in the long term.</p>","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143795719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Functional Observation Battery Test for Single Intravenous Caffeine Exposure in Male ICR Mice.","authors":"Sung-Hyun Cho, Yeon-Woo Kim, Miae Doo, Jung-Heun Ha","doi":"10.1089/jmf.2024.k.0289","DOIUrl":"https://doi.org/10.1089/jmf.2024.k.0289","url":null,"abstract":"<p><p>This study investigated the behavioral responses of male Institute for Cancer Research (ICR) mice to intravenous caffeine exposure via a functional observation battery (FOB) test. Thirty-two experimental mice were randomly assigned to four groups (<i>n</i> = 8 per group) and received intravenous caffeine at a dose of 0, 5, 10, or 20 mg/kg. Functional behaviors were observed at 0, 0.25, 1.5, 6, and 24 h after intravenous caffeine administration. Among the hand-held observations, the ease of removal from the cage and the ease of handling were significantly altered in all caffeine-exposed mice in both a dose-dependent and a time-dependent manner. In terms of physiological responses, both stimulus responses and locomotor activities were significantly affected by intravenous caffeine exposure. Specifically, the tail pinch response was significantly impaired in half of the mice in the 10 mg/kg and 20 mg/kg groups. Moreover, the rearing count decreased in the 10 mg/kg group at 1.5 to 6 h and in the 20 mg/kg group at 1.5 h after intravenous caffeine exposure. Furthermore, locomotor activity was markedly increased 0.25 h after intravenous caffeine administration in the 20 mg/kg group. These findings clearly indicate that intravenous caffeine exposure significantly impacts functional behaviors, as assessed by an FOB test, which is consistent with widely accepted safety pharmacology testing guidelines.</p>","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143780257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bioimpedance Phase Angle as a Diagnostic Tool of Nutritional Status in Children with Crohn's Disease on Exclusive Enteral Nutrition Therapy: One-Year Follow-Up Study.","authors":"Agata Wasilewska, Przemysław Tomasik, Aleksander Gałaś, Anna Stochel-Gaudyn, Dorota Drożdż, Krzysztof Fyderek, Małgorzata Sładek","doi":"10.1089/jmf.2023.0242","DOIUrl":"https://doi.org/10.1089/jmf.2023.0242","url":null,"abstract":"<p><p>Exclusive enteral nutrition (EEN) is highly effective in achieving remission and improving nutritional status in pediatric Crohn's disease (CD), commonly associated with altered body mass composition (BC). Bioimpedance analysis (BIA) with phase angle (PA) assessment is a noninvasive, reliable tool in screening for BC alterations. In the present study we aimed to assess the PA's usefulness in the detection of malnutrition in newly diagnosed pediatric CD, ongoing EEN treatment, and during 1-year follow-up. Patients and study design: Fourty-three patients with CD, qualified for EEN, were enrolled in the study. Additionally, 22 healthy children, being in the same age category, served as controls. Fat-free mass (FFM), fat-free mass index (FFMI), and BIA-derived PA were assessed at diagnosis, after EEN completion, and at week 52. The same parameters were obtained in the control group once. The majority of patients presented with normal body mass index at diagnosis. PA values were lower than 5 degrees in 65% of the study group. FFMI deficiencies were observed in 74% of patients. After EEN completion, an increase in FFM (<i>P</i> < .001) was observed. The highest mean of FFM (<i>P</i> < .001) and PA (<i>P</i> < .001) were observed at week 52. A strong correlation between PA and FFM at CD diagnosis (Spearman's rho = 0.671, <i>r</i> = 0.702, <i>P</i> < .001), after EEN completion (Spearman's rho = 0.781, <i>P</i> < .00) and at week 52 (Spearman's rho = 0.657, <i>P</i> < .001) was present. PA has been observed as positively associated with albumin concentrations both at diagnosis and after EEN. Our study provides some support that PA may be a reliable tool for screening alteration in BC, especially FFM and lean tissue mass (LTM). Moreover, PA has been observed as positively associated with albumin levels at CD diagnosis, which provides some evidence that it may be considered as a risk indicator of malnutrition and protein deficiency in newly diagnosed CD pediatric patients.</p>","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143780256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Therapeutic Role of Saffron and Its Components Mediated Through Nrf2 in Diabetes and Related Pathologies.","authors":"Mahboobeh Sabeti Akbar-Abad, Tahereh Farkhondeh, Mahdi Majidpour, Fariborz Samini, Michael Aschner, Effat Alemzadeh, Saeed Samarghandian","doi":"10.1089/jmf.2024.k.0135","DOIUrl":"https://doi.org/10.1089/jmf.2024.k.0135","url":null,"abstract":"<p><p>Today, diabetes is considered a growing global epidemic. In the diabetic environment, a large amount of reactive oxygen species are produced. This type of active oxygen causes severe damage to cell membranes, proteins, and DNA. Therefore, finding a solution to deal with and reduce this type of reactive oxygen is very important. One of the most effective ways to deal with oxidative damage and inflammation is the modulation of the nuclear factor erythroid 2 (Nrf2) signaling pathway. One of the useful natural substances that can be used for treatment in the signaling system is saffron. In this article, research evaluating the medicinal effects of saffron and its compounds and their mechanisms of action, especially the Nrf2 signaling pathway, have been investigated and studied. The results show that saffron and its components have the potential to treat diabetes due to their unique properties.</p>","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143764177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>Centella Asiatica</i> Fraction-3 Enhances Antioxidant Capacity and Apoptotic Cell Death in HEK293 Kidney Cells.","authors":"Dhaneshree B Naidoo, Alisa Phulukdaree, Anil Armichund Chuturgoon, Vikash Sewram","doi":"10.1089/jmf.2022.0109","DOIUrl":"https://doi.org/10.1089/jmf.2022.0109","url":null,"abstract":"<p><p>The traditional medicinal plant <i>Centella asiatica</i> is commonly used in Chinese and Ayurvedic medicine due to its vast range of therapeutic properties. Previously, the ethanolic <i>C. asiatica</i> leaf extract was subjected to silica column fractionation, and the C3 fraction was obtained. We investigated the antioxidant and anti-proliferative effects of C3 in human embryonic kidney (HEK293) cells. In HEK293 cells, C3 cytotoxicity was assessed (viability assay; 24 h; [0.2-3 mg/mL]), and a half maximal inhibitory concentration (IC₅₀) was determined. Malondialdehyde (MDA), lactate dehydrogenase (LDH) (spectrophotometry), mitochondrial depolarization (<i>Δψ</i>_m), intracellular reactive oxygen species (flow cytometry), glutathione (GSH), oxidized glutathione (GSSG) concentrations, caspase activities, ATP levels (luminometry), and fragmentation of DNA (SCGE assay) were evaluated. Protein expressions were assessed by western blotting. Gene expressions were quantified by qPCR. Cell viability in HEK293 cells was decreased in a dose-dependent manner by C3. MDA, <i>Δψ</i>_m, LDH, caspase activities, and DNA fragmentation (<i>P</i> < .0004) were significantly increased by C3. Nuclear factor erythroid 2-related factor 2 (Nrf-2) protein expression, GSH, and GSSG concentrations were increased, whereas antioxidant (<i>Nrf-2</i>, <i>GPx</i>, <i>SOD,</i> and <i>CAT</i>) gene expression was significantly decreased by C3 (<i>P</i> < .001). C3 decreased both Bax and Bcl-2 protein expression (<i>P</i> < .03). Gene expression of <i>c-myc</i> was significantly increased, whereas <i>OGG-1</i> was significantly reduced by C3 (<i>P</i> < .05). C3 reduced antioxidant gene expression, increased antioxidant levels, and elevated anti-proliferative effects in HEK293 cells, suggesting that high concentrations of C3 are potentially toxic to kidney cells, thus rendering cause for concern with its human use.</p>","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143753178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative Study of Two <i>Erythronium sibiricum</i> Bulb Polysaccharide Fractions in Alleviating Airway Remodeling by Affecting Autophagy and Apoptosis.","authors":"Shan Shan Gao, Yue Xuan Cheng, Yue Zhou, Rong Chang Liu, Xue Li, Xiang Yun Xie, Chun Chunli","doi":"10.1089/jmf.2024.k.0231","DOIUrl":"https://doi.org/10.1089/jmf.2024.k.0231","url":null,"abstract":"<p><p><i>Erythronium sibiricum</i> (<i>E. sibiricum</i>), which is an indigenous herb in China, is gathered and consumed by nomads in Xinjiang due to its medicinal value. Only a few studies have evaluated its possible pharmacological activity. This study aims to examine and compare the ways in which two <i>E. sibiricum</i> bulb polysaccharide fractions (ESBP and E1P) alleviate airway remodeling based on apoptosis and autophagy. In a mouse model of chronic asthma produced by ovalbumin, the anti-asthmatic effects of E1P and ESBP were investigated. The expression levels of the proteins linked to autophagy and apoptosis (cleaved-caspase 3, Beclin1, LC3B, Bad, and Bax) as well as the activity of the PI3K/Akt/mTOR signaling pathway were assessed. Airway remodeling was alleviated by E1P and ESBP. While E1P could only prevent the increase in PI3K, ESBP was capable of inhibiting the PI3K/Akt/mTOR signaling pathway. Furthermore, ESBP decreased the levels of cleaved-caspase 3, Beclin1, LC3B, Bad, and Bax protein expressions. By modifying signaling pathways linked to autophagy and apoptosis, <i>E. sibiricum</i> bulb polysaccharides successfully improved the airway remodeling of asthma. Additionally, ESBP exhibited more potent inhibitory effects on asthmatic defective autophagy than E1P.</p>","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143730477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Mixture of Nicotinamide Mononucleotide, Decursin, and l-Cysteine Lowered Senescence-Associated Markers In Vitro and Was Effective Against 2,4-Dinitrochlorobenzene-Induced Atopic Dermatitis In Vivo: An Application of Network Pharmacology.","authors":"Hyo Ri Shin, La Yoon Choi, Seong Hwan Bae, Tae Gyun Kim, Hyung Taek Cho, Tae Jin Cho, Nam Su Oh, Youn Young Shim, Martin J T Reaney, Jeong Hoon Pan, Jeong-Oh Shin, Eui-Cheol Shin, Seong-Gyu Ko, Jinbong Park, Yohan Han, Kyung-Chul Choi, Young Jun Kim, Wan Heo, Kangwook Lee, Jae Kyeom Kim","doi":"10.1089/jmf.2024.k.0282","DOIUrl":"https://doi.org/10.1089/jmf.2024.k.0282","url":null,"abstract":"<p><p>Skin aging, accelerated by oxidative stress from environmental factors, results in the breakdown of collagen and elastin, causing visible signs like wrinkles and inflammation. Natural antioxidants such as nicotinamide mononucleotide (NMN), decursin, and l-cysteine have shown potential in combating oxidative damage and inflammation. This study explored the effects of a formulated mixture of these compounds on skin aging and atopic dermatitis (AD) through a combination of <i>in vitro</i>, <i>in vivo</i>, and <i>in silico</i> methods. Using human keratinocyte cells, we assessed cytotoxicity via a cell viability assay, confirming NMN and l-cysteine were nontoxic up to 100 µM, while decursin exhibited toxicity above 10 µM. The intracellular oxidative stress measurement demonstrated that mixtures A and B, composed of the same concentrations of decursin and l-cysteine but differing in NMN levels (low in mixture A and moderate in mixture B), significantly reduced oxidative stress levels induced by 2,2'-azobis(2-amidinopropane) dihydrochloride, whereas mixture C, which contained the highest NMN concentration, was ineffective. Mixture B further reduced senescence-associated heterochromatin foci formation under oxidative stress, while mixture C caused cell structure disruptions. In the dinitrochlorobenzene-induced AD model in BALB/c mice, both, mixture-L and mixture-H treatments reduced epidermal thickness, scratching behavior, and transepidermal water loss, with mixture-L also lowering dermal thickness and mast cell infiltration. Gene expression analysis confirmed that mixture B decreased proinflammatory cytokines like <i>TNF-α</i> and <i>IL-6</i>, while network pharmacology predicted key antioxidant pathways, validated through restored <i>NOS2</i> gene expression. Overall, the findings highlight the potential of these compound mixtures to mitigate oxidative stress and inflammation, offering a promising approach for skin aging and dermatitis management, though further validation is needed to optimize efficacy and safety.</p>","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143699562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Laxative Effect of <i>Crataegus azarolus</i> Leaves Decoction Extract Against Loperamide-Induced Constipation and Oxidative Stress in Rats.","authors":"Houcem Sammari, Anouar Abidi, Saber Jedidi, Nourhène Dhawefi, Hichem Sebai","doi":"10.1089/jmf.2023.0255","DOIUrl":"https://doi.org/10.1089/jmf.2023.0255","url":null,"abstract":"<p><p>Constipation represents a common gastrointestinal disorder that has various adverse effects on the gastrointestinal tract. As a result, various civilizations have developed phytomedicines in order to treat and relieve its symptoms. In the current study, we evaluated the effect of <i>Crataegus azarolus</i> L. leaves decoction extract (CALDE) against loperamide (LOP)-induced constipation in rats. For 3 days, treated rats were administered LOP (3 mg/kg, <i>b.w., p.o</i>.) and CALDE (50, 100, and 200 mg/kg, <i>b.w., p.o.</i>) or yohimbine (2 mg/kg, <i>b.w., p.o</i>.). The gastric emptying test or intestinal transit time was calculated. The oxidative status was studied and evaluated using biochemical colorimetric methods. Results showed that CALDE administration improves gastric emptying and accelerates gastrointestinal transit. Pretreatment with LOP altered the defecation parameters and generated an oxidative status in healthy rats. In contrast, CALDE coadministration protected against the deregulation of intestinal motor function and frequency of defecation and significantly re-established oxidative marker levels. CALDE treatment demonstrated significant protection against experimental oxidative stress and constipation induced by LOP. Therefore, it can be considered a pharmacological drug to treat these gastrointestinal troubles.</p>","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143663679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Review of the Effects of Flavonoids on NAD(P)H Quinone Oxidoreductase 1 Expression and Activity.","authors":"Erik B Froyen, Gianluis Pimentel Barrantes","doi":"10.1089/jmf.2023.0132","DOIUrl":"https://doi.org/10.1089/jmf.2023.0132","url":null,"abstract":"<p><p>Cancer is a significant cause of death worldwide. It has been suggested that the consumption of flavonoids decreases the risk for cancer by increasing phase II enzymes, such as Nicotinamide Adenine Dinucleotide Phosphate Hydrogen (NAD(P)H) quinone oxidoreductase 1 (NQO1), glutathione S-transferases, and Uridine 5'-diphospho- (UDP)-glucuronosyltransferases that assist in removing carcinogens from the human body. Flavonoids are bioactive compounds found in a variety of dietary sources, including fruits, vegetables, legumes, nuts, and teas. As such, it is important to investigate which flavonoids are involved in the metabolism of carcinogens to help reduce the risk of cancer. Therefore, the objective of this narrative review was to investigate the effects of commonly consumed flavonoids on NQO1 mRNA expression, protein, and activity in human cell and murine models. PubMed was used to search for peer-reviewed journal articles, which demonstrated that selected flavonoids (<i>e.g.</i>, quercetin, apigenin, luteolin, genistein, and daidzein) increase NQO1, and therefore, increase the excretion of carcinogens. However, more research is needed regarding the mechanisms by which flavonoids induce NQO1. Furthermore, it is suggested that future efforts focus on providing precise flavonoid recommendations to decrease the risk factors for chronic diseases.</p>","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143649329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}