Journal of medicinal food最新文献

{"title":"Tea from Pods with Seeds of <i>Libidibia ferrea</i> (Jucá) Does Not Attenuate Inflammatory Reaction of Acute Colitis in Rats.","authors":"Marcela A B Fagiani, Ana P M Andrade, Anna C P Pereira, Arthur S Zulli, Bianca M E Estopa, Breno L G Rosa, Fabíola A Mello, Gracielle V Gonçalves, Isabella B Ferreira, Liliane G Pereira, Sandra C Genaro, Cecília L Santarém, Sabrina A Lenquiste","doi":"10.1177/1096620X251385497","DOIUrl":"https://doi.org/10.1177/1096620X251385497","url":null,"abstract":"<p><p>This study aimed to evaluate the effects of Jucá tea for curative treatment in rats with acute colitis. A total of 40 male <i>Wistar</i> rats (<i>n</i> = 10 per group) were fed a commercial ration and filtered water, wherein one group received Jucá tea by gavage. The rats were divided into the following groups: control, colitis control, drug control receiving sulfasalazine, and Jucá group, where the rats received an intermediate dose of the fruit (285 mg/kg/day). The disease activity index, macroscopic damage score of the large intestine (LI), histopathological analysis of the LI, biochemical examinations, and antioxidant measurements were performed. The group that received Jucá tea exhibited reduced water and feed consumption (<i>P</i> = .000) and presented a higher index of disease activity on days 1 (<i>P</i> = .000) and 7 (<i>P</i> = .004). Additionally, this group presented more severe intestinal lesions on histopathological evaluation of the total damage score (<i>P</i> = .017). The intestinal crypts were not negatively affected by tea consumption (<i>P</i> = .001). Jucá did not cause hepatic alterations in rats, as verified by alanine aminotransferase measurement (<i>P</i> = .04), but lowered albumin levels (<i>P</i> = .00). Jucá tea alters the dietary consumption in animals, is implicated in intestinal damage, and does not soften the inflammatory process caused by colitis. Jucá does not induce hepatotoxicity.</p>","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145251562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Almond Consumption on HDL Cholesterol and CVD Risk Factors in Adults with High Cholesterol: A Randomized, Comparator-Controlled Trial.","authors":"Katarina M Doma, Marc Moulin, David C Crowley, Najla Guthrie, Erin D Lewis","doi":"10.1177/1096620X251378321","DOIUrl":"https://doi.org/10.1177/1096620X251378321","url":null,"abstract":"<p><p>Dietary modifications are recommended for individuals with hypercholesterolemia to reduce cardiovascular disease (CVD) risk. While almonds have been shown to improve certain CVD risk factors, the effects of almonds on high-density lipoprotein cholesterol (HDL-C) are less clear. This study aimed to determine the quantity of almonds that would provide optimal increases in HDL-C in a population with hypercholesterolemia. Participants were randomized (<i>n</i> = 25/group) to low-dose almond (LDA; 1.5 oz/day), high-dose almond (HDA; 2.5 oz/day), or nut-free diet (NFD; cookies isocaloric to LDA) for 16 weeks. Change in HDL-C (primary outcome), Framingham Risk Score (FRS), blood pressure (BP), apolipoproteins, anthropometrics, and serum α-tocopherol were assessed at baseline and weeks 4, 8, 12, and 16. There were no significant differences in HDL-C between groups; however, there were reductions in FRS of 1.4% and 0.6% from baseline at week 16 in the HDA and LDA groups (<i>P</i> ≤ .05), respectively, while the NFD group had a 1.0% decrease (<i>P</i> = .14). There were decreases of 4.7 mmHg, 4.1 mmHg, 5.1 mmHg, and 3.8 mmHg in systolic BP for the HDA group after 4, 8, 12, and 16 weeks, respectively (<i>P</i> ≤ .06), which was significantly lower than the NFD group from baseline at week 8. The NFD group had increases in sagittal abdominal diameter of 4.0% and 2.7% after 4 and 8 weeks (<i>P</i> ≤ .05), respectively, whereas the almond groups did not. Findings suggest almond consumption may support dietary strategies for improving CVD risk factors in adults with hypercholesterolemia.</p>","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145251517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anti-Obesity Effects of Fatdizol, a Blend of <i>Rosmarinus officinalis</i> and <i>Morus alba</i>, in 3T3-L1 Cells and Obese Mouse Models.","authors":"Jinhee Kim, Yoonhee Lee, Seong-Hoo Park, Yeojin Jang, Juyeon Park, Jae Kyung Lee, Soo-Jeung Park, Yongbum Kwon","doi":"10.1089/jmf.2025.k.0024","DOIUrl":"10.1089/jmf.2025.k.0024","url":null,"abstract":"<p><p>This study explored the anti-obesity potential of Fatdizol, a blend composed of <i>Rosmarinus officinalis</i> L. and <i>Morus alba</i>, in differentiated 3T3-L1 adipocytes and in a high-fat diet (HFD)-induced obese mouse model. High-performance liquid chromatography analysis of Fatdizol verified the presence of two key bioactive constituents, rosmarinic acid and 1-deoxynojirimycin (1-DNJ), which are recognized for their anti-obesity effects. In vitro, the influence of Fatdizol on adipogenesis and lipogenesis was assessed through glycerol release assays, Oil Red O staining, and Western blotting. Fatdizol treatment notably reduced lipid accumulation and triglyceride content while enhancing glycerol release in differentiated adipocytes. In vivo, obesity was induced in C57BL/6J mice by administration of a 60% HFD, followed by oral supplementation with Fatdizol for 16 weeks. Various analyses, including micro-computed tomography imaging, enzyme-linked immunosorbent assay of plasma, adipose tissue, and feces, histological evaluation by hematoxylin and eosin staining of adipose tissues and liver, and western blot analysis, were conducted. Fatdizol administration significantly attenuated body weight gain, reduced white adipose tissue (WAT) and brown adipose tissue mass, improved serum lipid profiles, and decreased both systemic WAT accumulation and lipid droplet size. Mechanistically, Fatdizol inhibited adipogenic and lipogenic protein expression, enhanced lipolytic pathways, stimulated energy metabolism, activated the phosphatidylinositol 3-kinase/protein kinase B signaling axis, and promoted glucose metabolism. Collectively, these findings suggest that Fatdizol holds significant promise as a therapeutic agent for obesity management and may serve as a functional ingredient for health-promoting food development if its efficacy can be confirmed in human clinical trials.</p>","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":"1033-1046"},"PeriodicalIF":2.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144475650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Human Breast Milk-Derived Extracellular Vesicles Enhance Osteoblast Activation via BMP2/MAPK Signaling Pathways.","authors":"Jae-Hee Kwon, Hayeon Jang, Ji-Su Kim, Sang-Hoon Lee, Dong-Ha Kim, Young-Eun Cho, Han-Saem Park, Young-Eun Cho","doi":"10.1177/1096620X251360922","DOIUrl":"10.1177/1096620X251360922","url":null,"abstract":"<p><p>Human breast milk-derived extracellular vesicles (HMEVs) have various physiological functions, including immune regulation, cell regeneration, and inflammation suppression, as well as potential therapeutic applications; however, research on the role of HMEVs in bone growth and bone remodeling is insufficient. This study examined the effects of extracellular vesicles derived from human breast milk on osteoblast differentiation and mineralization and elucidated their role in the prevention and treatment of osteoporosis. The study's results showed that HMEVs significantly enhance osteoblast proliferation, differentiation, and mineralization, as confirmed by increased expression of proteins and genes related to bone formation. These effects are mediated via the bone morphogenetic protein 2 (BMP2) and mitogen-activated protein kinase (MAPK) signaling pathways. In other words, this study suggests that HMEVs may have a beneficial effect on the prevention and treatment of osteoporosis by promoting differentiation and mineralization of bone cells through the BMP2 and MAPK signaling pathways.</p>","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":"1047-1059"},"PeriodicalIF":2.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144715114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>Salacia Reticulata</i> Extract Improves Insulin Sensitivity and Glucose Homeostasis by Activating Insulin Signaling and Glucagon-like Peptide-1 Modulation.","authors":"Jaeeun Jung, Seong-Hoo Park, Wonhee Cho, Minhee Lee, Jinhak Kim, Yuri Gwon, Ok-Kyung Kim","doi":"10.1089/jmf.2025.k.0038","DOIUrl":"10.1089/jmf.2025.k.0038","url":null,"abstract":"<p><p>This study evaluated the effects of <i>Salacia reticulata</i> on glucose metabolism, insulin signaling, and key metabolic markers in type 2 diabetes (T2D). We evaluated how <i>S. reticulata</i> influences the activity of major enzymes responsible for carbohydrate breakdown. <i>In vitro</i> studies on C2C12 cells also examined glucose uptake and insulin signaling pathway activation. Otsuka Long-Evans Tokushima Fatty (OLETF) rats were treated with <i>S. reticulata</i> (25 and 50 mg/kg body weight [bw]) or metformin (126 mg/kg bw) for 16 weeks<i>. S. reticulata</i> suppressed the activities of α-glucosidase and α-amylase while promoting insulin signaling pathways and glucose uptake in C2C12 myotubes. In OLETF rats, administration of <i>S. reticulata</i> markedly enhanced glucose tolerance, lowered fasting blood glucose and HbA1c levels, and significantly decreased the homeostatic model assessment for insulin resistance (HOMA-IR) index, reflecting improved insulin sensitivity. Western blot analysis revealed increased insulin receptor substrate-1, PI3K, Akt, and activated protein kinase (AMPK) phosphorylation, along with upregulated GLUT4 expression in skeletal muscle. Serum glucagon-like peptide-1 (GLP-1) and adiponectin levels were significantly elevated in the <i>S. reticulata</i>-treated groups, helping improve insulin action and systemic metabolic regulation. As a result, <i>S. reticulata</i> exerts beneficial effects on insulin sensitivity and glucose homeostasis by affecting key mechanisms such as insulin signaling, incretin dynamics, and adipokine modulation, reinforcing its value as a n'atural agent for treating T2D and associated metabolic issues.</p>","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":"1060-1068"},"PeriodicalIF":2.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144310047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Protective Effect of Açai Seed Extract (<i>Euterpe oleracea</i> Mart.) Combined with Exercise Training on Cardiovascular Alterations, Oxidative Stress, and Loss of Physical Performance in Spontaneously Hypertensive Rats.","authors":"Beatriz Cardoso de Oliveira, Ricardo de Andrade Soares, Matheus Pontes de Menezes, Mariana Alencar Cavalheira, Dafne Lopes Beserra da Silva, Graziele Freitas de Bem, Dayane Teixeira Ognibene, Cristiane Aguiar da Costa, Roberto Soares de Moura, Angela Castro Resende","doi":"10.1177/1096620X251361429","DOIUrl":"10.1177/1096620X251361429","url":null,"abstract":"<p><p>Hypertension increases the risk of mortality from cardiovascular complications. The objective of this study was to evaluate whether <i>Euterpe oleracea</i> Mart. (açaí) seed extract (ASE), a polyphenol-rich Amazonian plant, and moderate exercise training (TR), in combination or not, exert beneficial effects on cardiovascular structural and functional changes, oxidative stress, and loss of physical performance (PP) in spontaneously hypertensive rats (SHR). Five groups were assigned: Control (CT), SHR, SHR + ASE (200 mg/kg/day by gavage), SHR + TR, and SHR + TR + ASE. The TR was performed on a treadmill for 8 weeks (5×/week) for 30 min. Blood pressure, cholesterol, and triglyceride levels were measured. Vascular reactivity was evaluated in the mesenteric arterial bed (MAB) and aortic ring. Aorta samples were obtained for biochemical, immunohistochemical, and morphological assessments. Running distance and exercise time increased in SHR + TR compared with the first maximal stress test. This performance was lost in the third test but restored with ASE. Hypertension, aorta hypertrophy, reduced acetylcholine-induced vasodilation, phosphorylated endothelial nitric oxide synthase (p-eNOS) expression, oxidative damage (3,4-methylenedioxyamphetamine), and superoxide dismutase activity were improved by ASE but not TR. ASE and TR alone improved endothelial dysfunction in MAB and fibrosis in the aorta. The lipid profile and glutathione peroxidase activity improvement were observed only in SHR + TR + ASE, and additional p-eNOS expression and anti-hypertrophy effect were observed. In conclusion, ASE was superior to TR as an antihypertensive strategy because it improved vascular endothelial dysfunction, hypertrophy, and oxidative stress in SHR. The association of both strategies further improves vascular hypertrophy, antioxidant defense, the loss of PP, and lipid profile, which may benefit hypertension-related cardiovascular risks.</p>","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":"974-982"},"PeriodicalIF":2.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144667785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>Monarda Fistulosa</i> Flower Extract Decreases Interleukin-6 Production by Lipopolysaccharide-Stimulated RAW 264.7 Murine Macrophages.","authors":"Makenna D Gerold, Sierra M Paske, Kara M Nell, Rachel M Gibbons Johnson, Bryan P Nell","doi":"10.1177/1096620X251362016","DOIUrl":"10.1177/1096620X251362016","url":null,"abstract":"<p><p><i>Monarda fistulosa (M. fistulosa)</i> is a flowering plant used as an herbal remedy due to its anti-inflammatory properties. In this study, we sought to test the anti-inflammatory properties of a <i>M. fistulosa</i> methanolic flower crude extract and found that the extract decreased lipopolysaccharide-induced interleukin-6 cytokine production by RAW 264.7 macrophages. We went on to characterize potential anti-inflammatory bioactive compounds present in the methanolic extract of <i>M. fistulosa</i> flower using liquid chromatography-tandem mass spectrometry and molecular networking analysis. In total, 183 compounds were putatively identified. These findings contribute to our knowledge of the anti-inflammatory medicinal properties and underlying chemistry of <i>M. fistulosa</i>.</p>","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":"993-1002"},"PeriodicalIF":2.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144715112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Apiaceous Vegetables Attenuated Inflammation Markers and Enriched Gut <i>Lachnospiraceae</i> in Mice Fed Western Diets.","authors":"Hee-Seop Lee, Rosa Moreno Narvaez, Daniel D Gallaher, Jianmin Chai, Jiangchao Zhao, Jeonghoon Pan, Jae Kyeom Kim, Sabrina P Trudo","doi":"10.1177/1096620X251361131","DOIUrl":"10.1177/1096620X251361131","url":null,"abstract":"<p><p>Western-style diets are positively correlated with many chronic diseases, including obesity, diabetes, coronary artery disease, inflammatory disease, and colon cancer. Western-style diets are characterized by high consumption of protein, fat, sugar, salt, and low intake of fruits and vegetables. Here, we compared the effect of western-style diets (diet-induced obesity [DIO] and the Total Western Diet [TWD]) on colonic inflammation and gut microbiome, and the effects of supplementing apiaceous vegetables (API; celery and parsnip) to those diets. Mice were fed the western-style diets with or without API for 12 weeks; control mice were given the AIN-93G diet. TWD-induced inflammatory gene expression (<i>p65</i>, <i>IκBα</i>, <i>TNF-α</i>, <i>IL-1β</i>), which was reversed by API supplementation. DIO promoted p65 phosphorylation, which was suppressed by API supplementation. In microbiome analyses, <i>α</i>-diversity was increased by DIO but decreased by TWD, which were not restored by API. Both DIO and TWD showed distinct microbial structures, as indicated by Bray-Curtis and Jaccard <i>β</i>-diversity indices, compared with AIN-93G, and were distinct from each other. API supplementation led to differentiation from the DIO and TWD, except for TWD in Jaccard. Random forest analysis identified altered key taxa: [<i>Ruminococcus</i>]<i>_gnavus</i> was DIO- and TWD-specifically increased taxa, which was decreased by API supplementation, and <i>Lachnospiraceae</i> was enriched by API in both DIO and TWD. In conclusion, DIO and TWD both altered microbial composition in ways that could contribute to colonic inflammation. API may mitigate this inflammatory compositional shift through modulating bacterial abundance belonging to <i>Lachnospiraceae</i> family when supplemented to both DIO and TWD.</p>","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":"983-992"},"PeriodicalIF":2.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144715113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Heat-Modified Cornstarch by a Homemade Process with Glucose Extended-Release for Possible Dietary Treatment of Glycogen Storage Diseases.","authors":"Ana M Calderón de la Barca, Guillermo Olivarría-Flores, Ana L Cota-Ojeda, Irma Z Olivares-Sandoval","doi":"10.1177/1096620X251366868","DOIUrl":"10.1177/1096620X251366868","url":null,"abstract":"<p><p>Glycogen storage diseases are genetic disorders involving glycogen storage or release. The cost of the modified starch (trademark Glycosade®) for treatment sometimes is not feasible, and patients are treated with oral uncooked cornstarch every 3 h. Our aim was to modify cornstarch at the lab and to translate it to a homemade process to extend glucose uptake for at least 5 h. We measured the transition phase of available cornstarch at low moisture. Then, cornstarch was heat-treated in a laboratory convection oven at 90, 95, and 100°C for 2 and 5 h and analyzed for <i>in vitro</i> hydrolysis and digestibility in comparison to Glycosade® by a cluster analysis. We replicated conditions in a kitchen roasting oven. A trial with 19 fasted healthy adults evaluated glucose after intake of 100 g/300 mL for 5 h. There were no phase transitions at 30% moisture, up to 100°C. At the lab, optimum conditions were 5 h at 90°C, with similar <i>in vitro</i> behavior to Glycosade®, and 95°C for 2 h in the kitchen roasting oven. The glucose levels of participants were maintained (106 to 95 mg/dL) along 5 h. In conclusion, euglycemia was prolonged at least 5 h after our product dosing as breakfast. The modified cornstarch could be prepared at home and used in patients with glycogen storage diseases, after clinical assessment.</p>","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":"1003-1008"},"PeriodicalIF":2.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144835371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antidiabetic Effects and Underlying Mechanisms of Food-Derived Bioactive Peptides.","authors":"Hatice Ozcaliskan Ilkay, Gulhan Samur","doi":"10.1089/jmf.2024.0018","DOIUrl":"10.1089/jmf.2024.0018","url":null,"abstract":"<p><p>Type 2 diabetes mellitus (T2DM), characterized by progressive insulin secretion defect based on insulin resistance, is one of the leading public health problems with high morbidity and mortality rates. Uncontrolled hyperglycemia, which becomes a more severe indication with obesity in T2DM patients, increases the risk of cardiovascular disease, kidney damage, and retinal disorder. Effective diabetes treatment is possible with a comprehensive approach that includes controlling blood glucose levels, improving pancreatic β cell functions, and supporting insulin sensitivity through body weight management, nutritional therapy, and drug therapy. At this point, food-derived bioactive peptides and protein hydrolysates, which draw attention with their structural similarity to regulatory peptides in human metabolism, have great potential in treating T2DM and regulating glucose metabolism. Various glucoregulatory properties of bioactive peptides come to the fore through antidiabetic mechanisms such as the digestion of carbohydrates, the release of intestinal hormones, insulin function and secretion, glucose uptake, and adipose tissue modification. This review aims to evaluate the roles of food-derived bioactive peptides and protein hydrolysates in controlling glycemia and insulin sensitivity and their antidiabetic mechanisms of action and to examine the difficulties and opportunities related to the acquisition and research processes.</p>","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":"955-963"},"PeriodicalIF":2.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144553781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}