Journal of medicinal food最新文献

Ellagic Acid Attenuates MASLD by Reducing Hepatic Lipogenesis and Fibrosis in ApoE^-/- Mice Fed a Cholesterol- and Cholate-Rich Paigen Diet. 鞣花酸通过减少ApoE-/-小鼠饲喂富含胆固醇和胆固醇的饲料的肝脏脂肪生成和纤维化来减轻MASLD。

IF 2 3区农林科学

Journal of medicinal food Pub Date : 2026-06-01 Epub Date: 2026-03-30 DOI: 10.1177/1096620X261438294

Yulim Choi, Eunkyeong Kim, Sin-Hye Park, Young-Hee Kang, Sookyoung Jeon

{"title":"Ellagic Acid Attenuates MASLD by Reducing Hepatic Lipogenesis and Fibrosis in ApoE-/- Mice Fed a Cholesterol- and Cholate-Rich Paigen Diet.","authors":"Yulim Choi, Eunkyeong Kim, Sin-Hye Park, Young-Hee Kang, Sookyoung Jeon","doi":"10.1177/1096620X261438294","DOIUrl":"10.1177/1096620X261438294","url":null,"abstract":"Metabolic dysfunction-associated steatotic liver disease (MASLD) is a chronic liver condition with a rising global incidence, closely linked to metabolic risk factors such as dyslipidemia. Apolipoprotein E-deficient (ApoE-/-) mice fed a Paigen diet are an established model for MASLD and atherosclerosis research. This study investigated the effects of ellagic acid (EA) on MASLD progression in ApoE-/- mice fed a Paigen diet. Wild-type (WT) and ApoE-/- mice were fed a Paigen diet for 10 weeks to induce metabolic dysregulation. ApoE-/- mice were concurrently administered either EA (10 mg/kg/day orally) or no treatment. After 10 weeks, ApoE-/- mice exhibited significant hepatic lipid accumulation, confirmed by increased Oil Red O staining. EA treatment significantly reduced hepatic lipid accumulation and lipid peroxidation. Furthermore, EA administration decreased hepatic expression of lipogenic proteins, including sterol regulatory element-binding protein 1, fatty acid synthase, and CCAAT/enhancer-binding protein alpha. The hepatic fibrogenic marker, α-smooth muscle actin (α-SMA), was significantly elevated in ApoE-/- mice compared with WT, and was significantly reduced by EA. In addition, transforming growth factor-β (TGF-β) protein levels and downstream SMAD signaling components, including phosphorylated SMAD2 and total SMAD2, SMAD3, and SMAD4, were significantly attenuated by EA treatment. In conclusion, EA effectively ameliorated MASLD and hypercholesterolemia in ApoE-/- mice fed a Paigen diet. The beneficial effects of EA may be mediated through downregulating lipogenic pathways and suppressing TGF-β/SMAD signaling.","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":"356-363"},"PeriodicalIF":2.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147574358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical Efficacy of the Probiotic Weissella cibaria CMU in Adults with Gingivitis: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial. 益生菌西巴利菌CMU治疗成人牙龈炎的临床疗效：一项随机、双盲、安慰剂对照临床试验

IF 2 3区农林科学

Journal of medicinal food Pub Date : 2026-06-01 Epub Date: 2026-03-12 DOI: 10.1177/1096620X261430298

Hee-Won Jeon, Keon-Il Yang, Sang-Joun Yu, Mi-Sun Kang, Won-Pyo Lee

{"title":"Clinical Efficacy of the Probiotic Weissella cibaria CMU in Adults with Gingivitis: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial.","authors":"Hee-Won Jeon, Keon-Il Yang, Sang-Joun Yu, Mi-Sun Kang, Won-Pyo Lee","doi":"10.1177/1096620X261430298","DOIUrl":"10.1177/1096620X261430298","url":null,"abstract":"Periodontal disease results from dysbiotic oral biofilms and the host's inflammatory response. Given the limitations of conventional therapies, this study aimed to evaluate the efficacy and safety of Weissella cibaria CMU (OraCMU) in improving gingival inflammation in individuals with gingivitis and incipient periodontitis. In this randomized, double-blind, placebo-controlled trial, 80 participants received either OraCMU tablets (2.0 × 108 CFU/g; n = 40) or placebo (n = 40) twice daily for 8 weeks. The primary outcome was the gingival index (GI), and secondary outcomes included bleeding on probing (BOP), probing depth, clinical attachment level, gingival recession, plaque index, inflammation-related proteins, and oral microbiota. Clinical parameters were assessed at six preselected index teeth (#16, 12, 24, 32, 36, and 44). At week 8, the probiotic group showed significantly greater reductions in GI (-0.19 ± 0.03 vs. -0.08 ± 0.04; P = .035) and BOP (-7.74 ± 1.54 vs. -2.82 ± 1.60; P = .030) compared with the placebo group. Inflammatory markers, including fibroblast growth factor-5 (P = .003), thymic stromal lymphopoietin (P = .017), and the receptor activator of nuclear factor κB ligand/osteoprotegerin ratio (P = .021), were significantly decreased. The levels of Porphyromonas gingivalis (P = .001), Treponema denticola (P = .005), and Prevotella intermedia (P = .046) were also significantly reduced, while Weissella increased (P < .001) in the probiotic group. Eight-week supplementation with OraCMU improved gingival health and modulated the oral microbiota and inflammatory response. No serious adverse events were reported during the study period. These findings support the potential clinical utility of OraCMU as a probiotic adjunct for managing gingivitis.","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":"319-331"},"PeriodicalIF":2.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147433738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Corrigendum to: "Clinical Efficacy of the Probiotic Weissella cibaria CMU in Adults with Gingivitis: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial". 更正：“益生菌西巴利菌CMU治疗成人牙龈炎的临床疗效：一项随机、双盲、安慰剂对照临床试验”。

IF 2 3区农林科学

Journal of medicinal food Pub Date : 2026-06-01 Epub Date: 2026-04-09 DOI: 10.1177/1096620X261441328

引用次数: 0

Effects of Lacticaseibacillus paracasei HP7 Against Helicobacter pylori-Induced Gastric Mucosal Inflammation and Mucosal Protection. 副干酪乳杆菌HP7抗幽门螺杆菌诱导的胃黏膜炎症及黏膜保护作用。

IF 2 3区农林科学

Journal of medicinal food Pub Date : 2026-06-01 Epub Date: 2026-03-23 DOI: 10.1177/1096620X261435979

Heewoo Lee, Jeong Yoon Lee, Jae-Ho Lee, Ju-Yeon Kim, Il-Dong Choi, Jae-Jung Shim, Jae-Hwan Lee, Yoo-Hyun Lee

{"title":"Effects of Lacticaseibacillus paracasei HP7 Against Helicobacter pylori-Induced Gastric Mucosal Inflammation and Mucosal Protection.","authors":"Heewoo Lee, Jeong Yoon Lee, Jae-Ho Lee, Ju-Yeon Kim, Il-Dong Choi, Jae-Jung Shim, Jae-Hwan Lee, Yoo-Hyun Lee","doi":"10.1177/1096620X261435979","DOIUrl":"10.1177/1096620X261435979","url":null,"abstract":"Helicobacter pylori (H. pylori) is a major pathogen that colonizes the human gastric surface and induces chronic inflammation and mucosal damage, leading to various gastric diseases. This study examined the gastroprotective effects of Lacticaseibacillus paracasei HP7 in an H. pylori-infected animal model. Male C57BL/6 mice were divided into four groups: normal control, H. pylori-infected control (HP), H. pylori-infected group treated with live L. paracasei HP7 for 4 weeks (L-HP7), and H. pylori-infected group treated with heat-killed L. paracasei HP7 for 4 weeks (HK-HP7). The results showed that serum histamine and gastrin levels, as well as gastric mucosal inflammatory cytokine mRNA levels, including interleukin (IL)-1β, IL-6, IL-8, IL-18, interferon gamma, and tumor necrosis factor alpha, were significantly reduced in both the L-HP7 and HK-HP7 groups. Histopathological scoring of hematoxylin & eosin-stained gastric mucosal tissues also showed significant improvements in both groups. Serum anti-H. pylori immunoglobulin G (IgG) and CCK2R mRNA levels decreased in the L-HP7 group, whereas MUC1 mRNA levels increased. Collectively, these findings indicate that L. paracasei HP7, in both live and heat-killed forms, protects gastric surface epithelial and mucosal cells and alleviates inflammatory status by reducing the expression of pro-inflammatory cytokines. L. paracasei HP7 may serve as a promising adjunct to antibiotics in the management of H. pylori-associated diseases.","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":"332-341"},"PeriodicalIF":2.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147498868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Inhaling Odor-Active Compounds of Osmanthus fragrans Var. aurantiacus Suppresses Inflammation-Related Transcriptomic Signatures in LPS-Exposed SD Rat Brains: Applications of GC-MS-O and RNA Sequencing. 吸入桂花的气味活性化合物抑制lps暴露SD大鼠脑中炎症相关的转录组特征：GC-MS-O和RNA测序的应用

IF 2 3区农林科学

Journal of medicinal food Pub Date : 2026-06-01 Epub Date: 2026-03-25 DOI: 10.1177/1096620X261429015

Moon Yeon Youn, Jae Kyeom Kim, Hyeonjin Park, Younglan Ban, Se Young Yu, Hee Sung Moon, Seong Jun Hong, Kangwook Lee, Hyo Ri Shin, Young Jun Kim, Eui-Cheol Shin

{"title":"Inhaling Odor-Active Compounds of Osmanthus fragrans Var. aurantiacus Suppresses Inflammation-Related Transcriptomic Signatures in LPS-Exposed SD Rat Brains: Applications of GC-MS-O and RNA Sequencing.","authors":"Moon Yeon Youn, Jae Kyeom Kim, Hyeonjin Park, Younglan Ban, Se Young Yu, Hee Sung Moon, Seong Jun Hong, Kangwook Lee, Hyo Ri Shin, Young Jun Kim, Eui-Cheol Shin","doi":"10.1177/1096620X261429015","DOIUrl":"10.1177/1096620X261429015","url":null,"abstract":"This study investigated the effects of nasal inhalation of Osmanthus fragrans var. aurantiacus (OFA) extract in lipopolysaccharide (LPS)-challenged rats. Electronic nose analysis of the OFA extracts identified 25 volatile organic compounds. Gas chromatography-mass spectrometry-olfactometry (GC-MS-O) analysis revealed that β-ionone, linalool, and related derivatives are the primary odor-active compounds in the OFA extract. LPS exposure increased pro-inflammatory markers like tumor necrosis factor-alpha, caused organ hypertrophy in the liver, lungs, and spleen, and altered transcriptional profiles linked to nuclear factor-kappa B (NF-κΒ) and immune pathways. RNA sequencing of brain tissues showed that while LPS strongly elevated NF-κΒ and cytokine pathways, this effect was less pronounced in OFA-treated rats, indicating reduced LPS-driven inflammation at the transcriptome level. Overall, these findings highlight the potential of OFA extract, abundant in β-ionone and linalool, to mitigate inflammatory signaling and improve select metabolic markers in an LPS-induced inflammatory model.","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":"342-355"},"PeriodicalIF":2.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147512836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Coffee Berry Pulp Extract Improves Hepatic Lipid Metabolism and Reduces Triglyceride Levels in High-Fat, High-Fructose Diet-Fed Mice. 咖啡浆果果肉提取物改善高脂肪、高果糖饮食小鼠的肝脏脂质代谢并降低甘油三酯水平。

IF 2 3区农林科学

Journal of medicinal food Pub Date : 2026-06-01 Epub Date: 2026-04-10 DOI: 10.1177/1096620X261441411

Mi Jeong Kim, Su Bin Lee, Dong Gun Park, Han-Hee Jo, Soonyeong Park, Jung-In Kim, Ji Youn Hong, Young Jun Kim, Bok Kyung Han

{"title":"Coffee Berry Pulp Extract Improves Hepatic Lipid Metabolism and Reduces Triglyceride Levels in High-Fat, High-Fructose Diet-Fed Mice.","authors":"Mi Jeong Kim, Su Bin Lee, Dong Gun Park, Han-Hee Jo, Soonyeong Park, Jung-In Kim, Ji Youn Hong, Young Jun Kim, Bok Kyung Han","doi":"10.1177/1096620X261441411","DOIUrl":"10.1177/1096620X261441411","url":null,"abstract":"This study examined the effects of coffee berry pulp (CBP) extract on hepatic lipid accumulation and blood lipid levels in mice fed on a high-fat, high-fructose (HFHF) diet. Male C57BL/6J mice were divided into the following four groups and fed their respective diets for 15 weeks: normal diet, HFHF diet, and HFHF diet supplemented with 100 or 200 mg/kg body weight CBP extract. CBP inhibited weight gain and normalized blood glucose and insulin levels. CBP supplementation also inhibited lipid and lipoprotein accumulation in the liver, thereby effectively regulating triglyceride (TG) levels in both the blood and liver. Analysis of liver lipid metabolism revealed that CBP suppressed the increased messenger RNA (mRNA) expression of sterol regulatory element-binding protein-1C induced by HFHF and downregulated both mRNA and protein levels of peroxisome proliferator-activated receptor-γ. Liver X receptor regulation occurred at the mRNA level, and the adenosine monophosphate-activated protein kinase (AMPK)/phosphorylated AMPK ratio was modulated at the protein level. Among the lipid catabolic enzymes, adipose TG lipase expression was specifically modulated by CBP treatment. These findings suggest that CBP supplementation modulates key hepatic lipid regulators and reduces blood and liver TG accumulation. Although CBP shows promise in regulating TG synthesis and storage in a mouse model, further studies, including clinical validation, are required to confirm its potential as a treatment for human non-alcoholic fatty liver disease.","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":"364-372"},"PeriodicalIF":2.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147654236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of Bromelain in Maternal Deprivation and Social Isolation Models of Schizophrenia in Male BALB/c Mice. 菠萝蛋白酶在雄性BALB/c小鼠精神分裂症母亲剥夺和社会隔离模型中的作用。

IF 2 3区农林科学

Journal of medicinal food Pub Date : 2026-05-06 DOI: 10.1177/1096620X261448411

Gideon Opeyemi Ayilara, Bamidele Victor Owoyele

{"title":"Effects of Bromelain in Maternal Deprivation and Social Isolation Models of Schizophrenia in Male BALB/c Mice.","authors":"Gideon Opeyemi Ayilara, Bamidele Victor Owoyele","doi":"10.1177/1096620X261448411","DOIUrl":"https://doi.org/10.1177/1096620X261448411","url":null,"abstract":"Bromelain is a mixture of enzymes found in several parts of the pineapple plant, including the stem, fruit, leaves, and peel. Its use was recommended to slow down the progression of neurological disorders such as Parkinson's disease. Although studies have examined the beneficial effects of bromelain (Br) in neurological disorders, its detailed benefits in schizophrenia are still poorly understood. We, thus, modeled schizophrenia using two developmental methods. In the first experiment, postweaning social isolation (SI) method where male mice were weaned at postnatal day (PND) 21 and isolated in individual cage for 5 weeks was used to induce schizophrenia. The second experiment used a maternal deprivation (MD) model, where mothers were separated from their pups for 24 h at PND 9. In both experiments 1 and 2, Br was administered orally from PND 21 to PND 56. At PND 56, there were behavioral assessments of nest building, anxiety, depression, and locomotion, while oxidative stress, neuroinflammation, brain-derived neurotrophic factor, and astrocyte expression in the prefrontal cortex and hippocampus were assessed at the end of the behavioral studies. Our study found that both SI and MD caused anxiety, depression, and hyperlocomotion. This was accompanied by oxidative stress in the prefrontal cortex and hippocampus, and neuroinflammation was observed only in the hippocampus. While SI rearing caused poor nest-building capacity, MD rearing did not impact nest-building capacity of the mice. The study found that administration of 50 mg/kg of Br reversed oxidative stress and neuroinflammation and significantly reduced anxiety level, hyperlocomotion, and depression in the mice. Mice administered Br also had a better nest-building capacity. Br may, therefore, benefit individuals at ultra-high risk and patients with schizophrenia, alleviating the positive, negative, and cognitive symptoms of the disease, without the side effects reported in the use of psychotic drugs.","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":"1096620X261448411"},"PeriodicalIF":2.0,"publicationDate":"2026-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147839203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Genetic Variation of Human Long-Chain Fatty Acyl-CoA Synthetase and Nutritional Implication. 人长链脂肪酰基辅酶a合成酶的遗传变异及其营养意义。

IF 2 3区农林科学

Journal of medicinal food Pub Date : 2026-05-01 Epub Date: 2026-03-23 DOI: 10.1177/1096620X261433056

So Young Bu

{"title":"Genetic Variation of Human Long-Chain Fatty Acyl-CoA Synthetase and Nutritional Implication.","authors":"So Young Bu","doi":"10.1177/1096620X261433056","DOIUrl":"10.1177/1096620X261433056","url":null,"abstract":"Interindividual genetic differences influence the metabolism, absorption, and utilization of nutrients in various biological processes. In nutrition research, elucidating gene functions and understanding polymorphisms are essential for clarifying how genetic variations influence individual responses to diet, metabolism, and health outcomes. Long-chain fatty acyl-CoA synthetase (ACSL) catalyzes the conversion of long-chain fatty acids into acyl-CoA forms, which are channeled into multiple metabolic processes. Several isoforms of ACSL have been identified, each with unique metabolic properties. The functional characterization of ACSL has been extensively explored both in vitro and in vivo in recent years. These experimental investigations of gene functions may provide valuable information for human applications. This review summarizes ACSL polymorphisms reported to date and their functional implications. Most studies on human ACSL have employed genome-wide association studies, and each reported ACSL single-nucleotide polymorphism (SNP) has been associated with specialized functions, but the metabolic effects of ACSL SNPs were moderate or, in some traits, remain inconclusive. Yet, the direction of gene expression or function based on each ACSL variant has not been clearly indicated in existing genome-wide association studies' results. Thus, ACSL-based target mechanisms for nutrition intervention could not be specified. Further research should be conducted on studies that employ expression quantitative trait loci datasets, standardized nutrition assessment, and polygenic score approaches.","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":"294-311"},"PeriodicalIF":2.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147499084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neohesperidin from Aurantii Fructus Immaturus Exerts Antidepressant-Like Effects and Modulates Glucocorticoid Receptor Signaling in a Chronic Stress Model. 枳实新橙皮苷在慢性应激模型中发挥抗抑郁样作用并调节糖皮质激素受体信号传导。

IF 2 3区农林科学

Journal of medicinal food Pub Date : 2026-05-01 Epub Date: 2026-03-19 DOI: 10.1177/1096620X261434812

Eunho Chun, Soojung Yoon, Hamid Iqbal, Sun Yeou Kim, Seon Hee Kim, Jeong June Choi, Mirim Jin

{"title":"Neohesperidin from Aurantii Fructus Immaturus Exerts Antidepressant-Like Effects and Modulates Glucocorticoid Receptor Signaling in a Chronic Stress Model.","authors":"Eunho Chun, Soojung Yoon, Hamid Iqbal, Sun Yeou Kim, Seon Hee Kim, Jeong June Choi, Mirim Jin","doi":"10.1177/1096620X261434812","DOIUrl":"10.1177/1096620X261434812","url":null,"abstract":"Depression, a mood disorder characterized by persistent negative emotions and impaired functioning, is associated with dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis and glucocorticoid receptor (GR) dysfunction. Aurantii Fructus Immaturus (AFI), the immature fruit of Citrus aurantium Linné, has been used in East Asian herbal medicine, and neohesperidin (NHD), a principal constituent of AFI, has been studied for its antidepressant properties. This study aimed to elucidate the mechanisms underlying the antidepressant effects of NHD, focusing on its ability to enhance GR expression and activity, thereby normalizing HPA axis function and mitigating neuroinflammation. AFI extract and its component NHD ameliorated depression-like behaviors in chronic restraint stress mice with normalized plasma corticosterone (CORT) levels. Moreover, NHD treatment reduced hippocampal expression of proinflammatory cytokine genes (TNFA, IL6, IL1A, and IL1B) while enhancing GR expression, particularly the NR3C1 exon 17 and 110 variants homologous to human GR variants implicated in depression. In cultured cells, NHD not only reversed CORT-induced neurite atrophy in N2a cells but also suppressed lipopolysaccharide-induced cytokine release in BV2 microglia. Notably, gene silencing of the GR via siRNA abrogated these neuritogenic and antineuroinflammatory effects, demonstrating that NHD exerts its antidepressant and neuroinflammation-suppressive actions in a GR-dependent manner. These findings suggest a promising therapeutic potential for AFI and NHD in stress-related depressive disorders, offering a multi-target approach that addresses both stress response and neuroinflammation through modulation of GR expression.","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":"257-267"},"PeriodicalIF":2.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147486357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lutein-Zeaxanthin Extract (XanMax^® 2002) Attenuates Oxidative Stress, Neuroinflammation, and Memory Deficits in H₂O₂-Exposed Neuro-2a Cells and Scopolamine-Induced Mice. 叶黄素-玉米黄素提取物（XanMax®2002）减轻h2o2暴露的神经2a细胞和东莨菪碱诱导小鼠的氧化应激、神经炎症和记忆缺陷。

IF 2 3区农林科学

Journal of medicinal food Pub Date : 2026-05-01 Epub Date: 2026-03-30 DOI: 10.1177/1096620X261430176

Yeonhwa Lee, Hyelim Kim, Jinhee Kim, Jeongjin Park, Yuri Gwon, Jinhak Kim, Priya Mk, Woojin Jun

{"title":"Lutein-Zeaxanthin Extract (XanMax® 2002) Attenuates Oxidative Stress, Neuroinflammation, and Memory Deficits in H2O2-Exposed Neuro-2a Cells and Scopolamine-Induced Mice.","authors":"Yeonhwa Lee, Hyelim Kim, Jinhee Kim, Jeongjin Park, Yuri Gwon, Jinhak Kim, Priya Mk, Woojin Jun","doi":"10.1177/1096620X261430176","DOIUrl":"10.1177/1096620X261430176","url":null,"abstract":"Age-related cognitive impairment is often linked to cholinergic dysfunction and increased oxidative stress. This study explored the neuroprotective potential of lutein-zeaxanthin extract (XanMax® 2002; LZ) through both in vitro and in vivo approaches. In vitro, Neuro-2a cells exposed to hydrogen peroxide (H2O2) were treated with LZ (5-20 μg/mL), leading to decreased expression of apoptosis-related proteins. In vivo, memory impairment was induced by scopolamine in C57BL/6N mice, followed by oral administration of LZ (4 or 8 mg/kg) for 4 weeks. Behavioral assessments-including the Morris water maze, Y-maze, and passive avoidance tests-demonstrated significant improvements in spatial learning, working memory, and memory retention in LZ-treated groups, particularly at the higher dose. Biochemical analysis revealed increased acetylcholine levels, reduced acetylcholinesterase activity, and downregulation of oxidative stress and neuroinflammatory markers in brain tissue. Moreover, LZ supplementation upregulated genes associated with synaptic function and memory. The cognitive-enhancing effects of LZ were comparable with those of donepezil. These findings suggest that LZ may exert neuroprotective effects through antioxidant and anti-inflammatory mechanisms and are a potential dietary intervention for cognitive decline.","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":"268-278"},"PeriodicalIF":2.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147574355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0