Journal of medicinal food最新文献

Standardized Curcuma xanthorrhiza Extract and Its Major Compound, Xanthorrhizol, Mitigate Cancer-Associated Muscle Atrophy in CT26-Bearing Mice by Inhibiting Catabolic Signaling Pathways.

IF 1.7 3区农林科学

Journal of medicinal food Pub Date : 2025-02-20 DOI: 10.1089/jmf.2024.k.0092

Haeun Kim, Taeuk Kim, Boeun Oh, Dong-Woo Lee, Jae-Kwan Hwang

{"title":"Standardized Curcuma xanthorrhiza Extract and Its Major Compound, Xanthorrhizol, Mitigate Cancer-Associated Muscle Atrophy in CT26-Bearing Mice by Inhibiting Catabolic Signaling Pathways.","authors":"Haeun Kim, Taeuk Kim, Boeun Oh, Dong-Woo Lee, Jae-Kwan Hwang","doi":"10.1089/jmf.2024.k.0092","DOIUrl":"https://doi.org/10.1089/jmf.2024.k.0092","url":null,"abstract":"Cancer cachexia, defined by the gradual depletion of muscle and fat mass, is a complex multifactorial syndrome affecting up to 80% of cancer patients. This study investigated the effects of Curcuma xanthorrhiza extract (CXE) and xanthorrhizol (XAN) in ameliorating cancer-induced muscle atrophy in BALB/c mice. Treatment with CXE and XAN reversed muscle mass loss, grip strength decline, and decrease in myofiber size induced by cancer. In gastrocnemius muscle tissue, CXE and XAN downregulated the expression of nuclear factor kappa-beta (NF-κB), reducing the expression levels of proinflammatory cytokines. They also suppressed catabolic factors, including myostatin and ubiquitin-proteasome E3 ligases, and the nuclear translocation of forkhead box O3a. Furthermore, CXE and XAN promoted skeletal muscle anabolism by stimulating myogenesis and activating the phosphoinositide 3-kinase/protein kinase B signaling pathway. This activation subsequently upregulated the mammalian target of rapamycin and its downstream molecules. Overall, CXE and XAN effectively mitigated skeletal muscle catabolism induced by cancer cachexia and may serve as an intervention for inhibiting muscle atrophy in affected cancer patients if efficacy can be confirmed in human trials.","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143457910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Aruncus Dioicus Var. Kamtschaticus Extract Prevents Ocular Endoplasmic Reticulum Stress, Inflammation, and Oxidative Stress In Vitro.

IF 1.7 3区农林科学

Journal of medicinal food Pub Date : 2025-02-20 DOI: 10.1089/jmf.2024.k.0240

Sunyoung Jeong, Miae Doo, Kihun Sung, Young Jun Kim, Jong-Hwa Lee, Jung-Heun Ha

{"title":"Aruncus Dioicus Var. Kamtschaticus Extract Prevents Ocular Endoplasmic Reticulum Stress, Inflammation, and Oxidative Stress In Vitro.","authors":"Sunyoung Jeong, Miae Doo, Kihun Sung, Young Jun Kim, Jong-Hwa Lee, Jung-Heun Ha","doi":"10.1089/jmf.2024.k.0240","DOIUrl":"https://doi.org/10.1089/jmf.2024.k.0240","url":null,"abstract":"The aim of this study was to determine the anti-inflammatory and anti-endoplasmic reticulum (ER) stress effects of Aruncus dioicus var. kamtschaticus (ADK) extract on ARPE-19 cells. Pretreatment with ADK effectively mitigated thapsigargin (Tg)-induced increases in vascular endothelial growth factor protein secretion and intracellular calcium levels. Furthermore, pretreatment with ADK suppressed ocular ER stress-related protein expression in a dose-dependent manner, inhibited the loss of tight junctions, and suppressed interleukin-6 gene expression. Moreover, ADK pretreatment significantly prevented lipopolysaccharide-inducible proinflammatory cytokine gene expression at the transcription level and the phosphorylation of proteins involved in the mitogen-activated protein kinase-nuclear factor kappa-light-chain-enhancer of activated B cells (NFκB) axis at the posttranslational level. Additionally, ADK extract enhanced antioxidant activity, as evidenced by increased heme oxygenase-1 protein expression and increased 2,2-diphenyl-1-picrylhydrazyl radical scavenging and ferric-reducing antioxidant power. In conclusion, ADK extract effectively protected ARPE-19 cells from ocular ER stress, inflammation, and oxidative stress, demonstrating its potential as a nutraceutical intervention for ocular diseases.","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143457909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enzymatic Hydrolysate of Low-Molecular-Weight Soybean Peptides Suppresses Hydrogen Peroxide-Induced Apoptosis of Murine Myoblast C2C12 Cells Possibly via AMPK Activation.

IF 1.7 3区农林科学

Journal of medicinal food Pub Date : 2025-02-06 DOI: 10.1089/jmf.2024.k.0278

Wan Heo, Jeong Hoon Pan

{"title":"Enzymatic Hydrolysate of Low-Molecular-Weight Soybean Peptides Suppresses Hydrogen Peroxide-Induced Apoptosis of Murine Myoblast C2C12 Cells Possibly via AMPK Activation.","authors":"Wan Heo, Jeong Hoon Pan","doi":"10.1089/jmf.2024.k.0278","DOIUrl":"https://doi.org/10.1089/jmf.2024.k.0278","url":null,"abstract":"Skeletal muscle health is essential for metabolic homeostasis, and dysregulated apoptosis in muscle cells can lead to muscle wasting and degenerative diseases. Although soybean-derived peptides are known for their bioactive properties, including antioxidant and anti-apoptotic effects, their impact on apoptosis regulation in skeletal muscle cells remains underexplored. This study aims to investigate the effects of low-molecular-weight soy peptide hydrolysate (SPH) on apoptosis and related markers in C2C12 myoblasts. SPH was prepared by enzymatic hydrolysis, and its antioxidant and anti-apoptotic activities were analyzed through in vitro assays (i.e., ABTS, DPPH). Cellular studies were used to evaluate SPH effects on ROS scavenging and apoptosis. Results show that SPH enhanced antioxidant activity, reduced ROS levels, and promoted cell proliferation in a dose-dependent manner. SPH notably decreased apoptosis under oxidative stress by down-regulating p53, c-Caspase-3, and Cyto-c, while promoting HO-1 expression, likely via AMPK activation. Importantly, SPH had no significant impact on inflammation-related proteins or MAPK activation. These findings suggest that SPH may have therapeutic potential against oxidative stress and apoptosis in muscle cells through intrinsic pathways, contributing to muscle health maintenance.","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143256097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pharmacological Evaluation of Respiratory Safety Following a Single Intravenous Administration of Theophylline in Sprague-Dawley Rats.

IF 1.7 3区农林科学

Journal of medicinal food Pub Date : 2025-02-05 DOI: 10.1089/jmf.2024.k.0275

Sung-Hyun Cho, Minseo Cho, Miae Doo, Jung-Heun Ha

{"title":"Pharmacological Evaluation of Respiratory Safety Following a Single Intravenous Administration of Theophylline in Sprague-Dawley Rats.","authors":"Sung-Hyun Cho, Minseo Cho, Miae Doo, Jung-Heun Ha","doi":"10.1089/jmf.2024.k.0275","DOIUrl":"https://doi.org/10.1089/jmf.2024.k.0275","url":null,"abstract":"Drinking tea is an important cultural and sensory activity in modern society. However, tea consumption may influence biological functions because of its high polyphenol and methylxanthine content. Theophylline is a methylxanthine that plays a significant role in respiratory physiology and is used clinically as a bronchodilator. In this study, we assessed the pharmacological safety of theophylline by investigating its effects on the respiratory responses of experimental rodents. Six-week-old male Sprague-Dawley rats were intravenously administered 0, 2.5, 5, or 10 mg/kg theophylline. After systemic theophylline exposure, the respiratory rate, tidal volume, and minute volume were monitored and statistically analyzed. There was a significant increase in respiratory rate and minute volume with no change in tidal volume at theophylline doses of >5 mg/kg. Changes in respiratory rate and minute volume peaked at 0.25 h after exposure; the respiratory rate increased by 58.2% and 88.9%, and the minute volume increased by 50.5% and 72.8% with the 5 and 10 mg/kg doses, respectively, compared with the vehicle control. These results provide fundamental scientific data that can be used in clinical applications.","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143189318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Narrative Review of Moringa oleifera Lam., Moringaceae, Swietenia mahagoni L. Jacq., Meliaceae, and Momordica charantia L., Cucurbitaceae Plants Found in The Bahamas as Antidiabetes Phytomedicine. 辣木叙事述评。；辣木科；发现于巴哈马群岛的瓜科植物，作为抗糖尿病植物药物。

IF 1.7 3区农林科学

Journal of medicinal food Pub Date : 2025-02-01 Epub Date: 2024-12-11 DOI: 10.1089/jmf.2024.0100

Gloria Miller, Oliver Grundmann

{"title":"A Narrative Review of Moringa oleifera Lam., Moringaceae, Swietenia mahagoni L. Jacq., Meliaceae, and Momordica charantia L., Cucurbitaceae Plants Found in The Bahamas as Antidiabetes Phytomedicine.","authors":"Gloria Miller, Oliver Grundmann","doi":"10.1089/jmf.2024.0100","DOIUrl":"10.1089/jmf.2024.0100","url":null,"abstract":"Moringa (Moringa oleifera Lam., Moringaceae), West Indian mahogany (Swietenia mahagoni [L.] Jacq., Meliaceae), and Cerasee (Momordica charantia L., Cucurbitaceae) are plants that are used for medicinal purposes in The Bahamas. They have various medicinal uses, including treating diabetes, anemia, inflammation, dermatological issues, backaches, cold, flu, and gastrointestinal problems. This review aims to summarize the current knowledge about natural products found in The Bahamas that can be used to treat diabetes mellitus. The search terms \"Moringa oleifera Lam.,\" \"Swietenia mahagoni (L.),\" \"Momordica charantia L.,\" \"Tecoma stans,\" \"Persea americana,\" \"Psidium guajava,\" \"Hamelia patens,\" and \"Carica papaya L.\" in combination with \"diabetes\" were utilized to obtain pertinent data by searching PubMed and Google Scholar. Moringa oleifera Lam. significantly decreased fasting glucose levels in rodents after 3 months of consumption. The ethanolic extract of S. mahagoni seeds and the methanol extract of its bark can decrease blood glucose levels. Momordica charantia L. and H. patens Jacq. produce the same hypoglycemic effects as metformin. The plant extracts and compounds of T. stans (L.) Juss. ex Kunth, P. americana Mill., P. guajava L., and C. papaya L. showed diverse pharmacological activities such as reducing fasting glucose, lowering blood pressure and blood sugar, decreasing total triglycerides and total cholesterol, and improving structural damage of cardiac muscles caused by diabetes. Literature analysis reveals that the diverse pharmacological activities of various plants native to The Bahamas show promise as a medicinal food in the treatment of diabetes.","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":"119-126"},"PeriodicalIF":1.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142807244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cordyceps cicadae Extracts Exert Antiaging Effects by Activating the AMPK/SIRT1 Pathway in d-Galactose-Induced Aging Rats. 冬虫夏草提取物通过激活AMPK/SIRT1通路在d-半乳糖诱导的衰老大鼠中发挥抗衰老作用

IF 1.7 3区农林科学

Journal of medicinal food Pub Date : 2025-02-01 Epub Date: 2024-11-25 DOI: 10.1089/jmf.2024.k.0132

Yangzhen Liao, Zhaoyong Zhou, Xue Jiang, Feixuan Wang, Jingqiong Wan, Shangyu Liu, Xia Deng, Yuan Wei, Zhen Ouyang

{"title":"Cordyceps cicadae Extracts Exert Antiaging Effects by Activating the AMPK/SIRT1 Pathway in d-Galactose-Induced Aging Rats.","authors":"Yangzhen Liao, Zhaoyong Zhou, Xue Jiang, Feixuan Wang, Jingqiong Wan, Shangyu Liu, Xia Deng, Yuan Wei, Zhen Ouyang","doi":"10.1089/jmf.2024.k.0132","DOIUrl":"10.1089/jmf.2024.k.0132","url":null,"abstract":"Cordyceps cicadae, a valuable traditional edible and medicinal resource, is recognized for its potential in slowing aging but has not been effectively exploited. This study aimed to explore antiaging activity and mechanisms of C. cicadae extracts (CCe). We used liquid chromatography-mass spectrometry to identify 23 CCe compounds and focused on quantifying six nucleoside components as quality markers. We also assessed the antiaging influences in d-galactose (d-gal)-induced aging rats. CCe improved learning memory deficits, enhanced organ indices, and mitigated oxidative brain damage caused by d-gal. CCe elevated superoxide dismutase and glutathione peroxidase activities, while downregulating malondialdehyde. Molecular analyses indicated the involvement of adenosine 5'-monophosphate-activated protein kinase/sirtuin 1 (AMPK/SIRT1) pathway in the antiaging mechanism of CCe. This study demonstrates the potential of CCe in mitigating d-gal-induced damage in aging rats, with the AMPK/SIRT1 pathway emerging as a regulatory axis. These findings contribute to the theoretical foundation for developing antiaging pharmaceuticals and functional foods using CCe, offering promising applications in aging-related contexts in succinct manner.","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":"144-155"},"PeriodicalIF":1.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142710493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Standardized Boesenbergia pandurata Extract Prevents Dexamethasone-Induced Muscle Atrophy and Dysfunction in C57BL/6 Mice. 标准白参提取物对C57BL/6小鼠地塞米松诱导的肌肉萎缩和功能障碍的预防作用

IF 1.7 3区农林科学

Journal of medicinal food Pub Date : 2025-02-01 Epub Date: 2024-12-04 DOI: 10.1089/jmf.2024.k.0182

Minseong Kang, Taeuk Kim, Heeyeon Joo, Doun Kim, Dong-Woo Lee, Jae-Kwan Hwang

{"title":"Standardized Boesenbergia pandurata Extract Prevents Dexamethasone-Induced Muscle Atrophy and Dysfunction in C57BL/6 Mice.","authors":"Minseong Kang, Taeuk Kim, Heeyeon Joo, Doun Kim, Dong-Woo Lee, Jae-Kwan Hwang","doi":"10.1089/jmf.2024.k.0182","DOIUrl":"10.1089/jmf.2024.k.0182","url":null,"abstract":"Muscle atrophy, characterized by diminished muscle mass and impaired function, poses a substantial global health concern. Boesenbergia pandurata (Roxb.) Schltr., commonly known as fingerroot, possesses a variety of advantageous activities, including anti-inflammatory, antioxidant, antibacterial, and anticancer effects. However, there are currently no preclinical studies available that explore the potential of B. pandurata extract (BPE) to mitigate muscle atrophy. In this study, we aimed to explore the protective effects of BPE, standardized to panduratin A content, against muscle atrophy and its underlying molecular mechanisms in a dexamethasone-induced muscle atrophy mouse model. Compared with the dexamethasone group, BPE significantly restored muscle mass, muscle volume, muscle fiber cross-sectional area, grip strength, and exercise endurance. Additionally, BPE suppressed inflammatory responses by downregulating the expressions of nuclear factor kappa B and inflammatory cytokines while also enhancing antioxidant effects by increasing the expressions of antioxidant enzymes. Moreover, BPE promoted protein synthesis and muscle differentiation by stimulating the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin signaling pathway. Furthermore, it suppressed myostatin expression and inhibited the expressions of E3 ubiquitin ligases by preventing the nuclear translocation of forkhead box O3a, thereby alleviating proteolysis. Overall, BPE effectively regulates unbalanced protein metabolism, suggesting its potential as a functional food ingredient for preventing muscle wasting diseases.","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":"182-190"},"PeriodicalIF":1.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142769567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ginsenoside Rg1 Promotes Wound Healing in Mice with Superficial Second-Degree Burns Through Energy Metabolism, Cell Migration, and Cell Adhesion Pathways. 人参皂苷 Rg1 通过能量代谢、细胞迁移和细胞粘附途径促进浅二度烧伤小鼠的伤口愈合

IF 1.7 3区农林科学

Journal of medicinal food Pub Date : 2025-02-01 Epub Date: 2024-10-29 DOI: 10.1089/jmf.2024.k.0146

Yunna Qin, Ziyu Zhang, Ru Jiang

{"title":"Ginsenoside Rg1 Promotes Wound Healing in Mice with Superficial Second-Degree Burns Through Energy Metabolism, Cell Migration, and Cell Adhesion Pathways.","authors":"Yunna Qin, Ziyu Zhang, Ru Jiang","doi":"10.1089/jmf.2024.k.0146","DOIUrl":"10.1089/jmf.2024.k.0146","url":null,"abstract":"Natural products are known to have distinct roles in the treatment of various diseases. However, the potential role of ginsenoside Rg1 (GRg1) in the context of scald injuries remains unclear. This study aimed to elucidate the effects of GRg1 on scald wound healing by utilizing a mouse scald wound model and administering varying concentrations of GRg1 orally. RNA sequencing (RNA-seq) was employed to identify the signaling pathways and key genes influenced by GRg1 in the wound healing process. Our findings indicate that mice treated with a low concentration of GRg1 exhibited a significantly higher wound healing rate compared with the model group and other treatment groups. Through RNA-seq, we observed that the gene expression profile in the wound tissues of the low-concentration-treated group was consistent with that of the normal control group. Furthermore, a low concentration of GRg1 was found to maintain cellular energy metabolism homeostasis by enhancing mitochondrial aerobic respiration and the tricarboxylic acid cycle. In addition, GRg1 facilitated wound healing by restoring the expression of genes associated with cell migration and adhesion. Confirming the appropriate concentration of GRg1 that accelerates tissue healing at scald sites and enhances our understanding of the efficacy and molecular mechanisms underlying the therapeutic effects of natural products in disease treatment.","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":"165-173"},"PeriodicalIF":1.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142522093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Beneficial Effects of CGK012 Against Lipopolysaccharide-Induced Inflammation.

IF 1.7 3区农林科学

Journal of medicinal food Pub Date : 2025-02-01 Epub Date: 2025-02-03 DOI: 10.1089/jmf.2024.k.0194

Jinhee Lee, Jong Beom Heo, Hae Joon Heo, Gaewon Nam, Gyu Yong Song, Jong-Sup Bae

{"title":"The Beneficial Effects of CGK012 Against Lipopolysaccharide-Induced Inflammation.","authors":"Jinhee Lee, Jong Beom Heo, Hae Joon Heo, Gaewon Nam, Gyu Yong Song, Jong-Sup Bae","doi":"10.1089/jmf.2024.k.0194","DOIUrl":"10.1089/jmf.2024.k.0194","url":null,"abstract":"This study investigates the protective effects of CGK012 [(7S)-(+)-cyclopentyl carbamic acid 8,8-dimethyl-2-oxo-6,7-dihydro-2H,8H-pyrano[3,2-g]chromen-7-yl-ester], a small-molecule inhibitor targeting the Wnt/β-catenin signaling pathway, against inflammatory responses elicited by lipopolysaccharide (LPS). The study evaluated the influence of CGK012 on heme oxygenase (HO)-1, cyclooxygenase (COX)-2, and inducible nitric oxide synthase (iNOS) expressions in LPS-stimulated human endothelial cells. It examined its effects on iNOS, tumor necrosis factor (TNF)-α, and interleukin (IL)-1β in LPS-challenged mice. CGK012 treatment resulted in increased HO-1 production, inhibited nuclear factor-kappa B activation, and decreased the levels of COX-2/PGE2 and iNOS/NO. Additionally, CGK012 reduced signal transducer and activator of transcription-1 phosphorylation and facilitated Nrf2 nuclear translocation and binding to antioxidant response elements, culminating in reduced IL-1β production in LPS-exposed human umbilical vein endothelial cells. Notably, the inhibitory effect of CGK012 on iNOS/NO was reversed upon HO-1 knockdown via RNA interference. In vivo, CGK012 markedly attenuated iNOS expression in lung tissue and decreased TNF-α levels in bronchoalveolar lavage fluid. These findings underscore the anti-inflammatory potential of CGK012, suggesting its therapeutic promise for conditions characterized by pathological inflammation.","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":"156-164"},"PeriodicalIF":1.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143080373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Honey from Different Species of Stingless Bees (Apidae: Meliponini) is Effective Against Gram-Positive and Gram-Negative Bacteria. 不同种类无刺蜂的蜂蜜对革兰氏阳性和革兰氏阴性细菌有效。

IF 1.7 3区农林科学

Journal of medicinal food Pub Date : 2025-02-01 Epub Date: 2024-12-24 DOI: 10.1089/jmf.2023.0107

Mayara Faleiros-Quevedo, Gabriel Reginatto Silva, Aline Negromonte Dos Santos, Tiago Maurício Francoy

{"title":"Honey from Different Species of Stingless Bees (Apidae: Meliponini) is Effective Against Gram-Positive and Gram-Negative Bacteria.","authors":"Mayara Faleiros-Quevedo, Gabriel Reginatto Silva, Aline Negromonte Dos Santos, Tiago Maurício Francoy","doi":"10.1089/jmf.2023.0107","DOIUrl":"10.1089/jmf.2023.0107","url":null,"abstract":"Stingless bee honey is a natural product consisting of sugars, organic acids, proteins, minerals, vitamins, phenolic compounds, and flavonoids. Due to its healing properties, honey is often used in phytotherapy and for homemade syrups. The search for natural therapeutic alternatives has been an increasing trend in recent years, mainly due to the side effects of artificial drugs and increasing antibiotic resistance. Therefore, the aim of this study was to characterize physicochemical properties and the antimicrobial activity of honey from different species of stingless bees against the pathogenicity of the bacteria Escherichia coli and Staphylococcus aureus and to determine the minimum inhibitory concentrations (MICs) and minimum bactericidal concentrations (MBCs). Honey samples from 15 different species of stingless bees from different regions of Brazil were used, and the analysis was performed by the broth microdilution method. We found a large variation in the physicochemical features among all the samples and no correlation to the MIC or MBC. It was also found that honey produced by Melipona rufiventris and Scaptotrigona tubiba were the most effective in combating pathogenic microorganisms due to its high antimicrobial activity, comparable to the results found for propolis. These data are important for the development of new strategies for the prevention and control of diseases caused by pathogenic microorganisms.","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":"198-204"},"PeriodicalIF":1.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142885908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0