Journal of medicinal food最新文献_第2页

Flavonoid Derivatives Isolated from Hypericum monogynum Ameliorate Insulin Resistance via Modulation of IRS-1/PI3K/Akt/FOXO1 Pathway in HepG2 Cells. 金丝桃黄酮衍生物通过调节IRS-1/PI3K/Akt/FOXO1通路改善HepG2细胞的胰岛素抵抗。

IF 1.7 3区农林科学

Journal of medicinal food Pub Date : 2025-03-01 Epub Date: 2024-12-23 DOI: 10.1089/jmf.2024.k.0242

Seungjoo Baik, Yunhua Qianshi, Samuel Park, Hana Lee, Huijin Heo, Junsoo Lee, Chunmao Yuan, Jeehye Sung

{"title":"Flavonoid Derivatives Isolated from Hypericum monogynum Ameliorate Insulin Resistance via Modulation of IRS-1/PI3K/Akt/FOXO1 Pathway in HepG2 Cells.","authors":"Seungjoo Baik, Yunhua Qianshi, Samuel Park, Hana Lee, Huijin Heo, Junsoo Lee, Chunmao Yuan, Jeehye Sung","doi":"10.1089/jmf.2024.k.0242","DOIUrl":"10.1089/jmf.2024.k.0242","url":null,"abstract":"In this study, two high-content flavonoid derivatives [3-8 biapigenin (HM 104) and quercetin-3-O-β-d-galactopyranoside (HM 111)] were obtained through the bioactivity-guided isolation of antidiabetic compounds from Hypericum monogynum flowers. HM 104 and HM 111 exhibited good glucose consumption in fatty acid-induced insulin-resistant HepG2 cells. Moreover, both active compounds enhanced glucose uptake by restoring the expression of key regulators of glucose metabolism, including insulin receptor substrate 1, phosphoinositide 3-kinase, protein kinase B, and glucose transporter type 4, and by mitigating the expression of forkhead box O1 and the factors involved in gluconeogenesis. They upregulate the phosphorylation of glycogen synthase kinase-3β, which may affect glycogen synthesis. Furthermore, the production of reactive oxygen species was decreased by the two compounds. This study provides novel mechanistic insights into the protective effects of flavonoid derivatives isolated from H. monogynum flowers in preventing and managing insulin resistance and associated metabolic disorders.","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":"243-255"},"PeriodicalIF":1.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142876502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chrysanthemum Zawadskii Var. and Platycodon Grandifloras Extract Mixture Protects Against Lipopolysaccharide-Induced Pulmonary Inflammation and Cyclophosphamide-Induced Immune Deficiency: In Vivo Evidence. 菊花和桔梗提取物混合物对脂多糖诱导的肺部炎症和环磷酰胺诱导的免疫缺陷的体内证据。

IF 1.7 3区农林科学

Journal of medicinal food Pub Date : 2025-03-01 Epub Date: 2025-01-06 DOI: 10.1089/jmf.2024.k.0245

Dong-Uk Jo, Yongeun Kim, Heejin Ko, Sujung Hong, Wonchul Lim, Tae-Gyu Lim

{"title":"Chrysanthemum Zawadskii Var. and Platycodon Grandifloras Extract Mixture Protects Against Lipopolysaccharide-Induced Pulmonary Inflammation and Cyclophosphamide-Induced Immune Deficiency: In Vivo Evidence.","authors":"Dong-Uk Jo, Yongeun Kim, Heejin Ko, Sujung Hong, Wonchul Lim, Tae-Gyu Lim","doi":"10.1089/jmf.2024.k.0245","DOIUrl":"10.1089/jmf.2024.k.0245","url":null,"abstract":"Respiratory tract diseases (RTDs) cause airflow limitations and impaired respiratory function, primarily due to pulmonary inflammation and immune dysfunction. Chrysanthemum zawadskii var. latilobum Kitamur and Platycodon grandifloras (CP) are traditional herbs known for their anti-inflammatory and immune-enhancing properties. This study investigates the anti-inflammatory and immune-enhancing effects of a combined extract of CP in vivo. CP was prepared by mixing equal volumes of Chrysanthemum zawadskii extract (CE) and Platycodon grandifloras extract (PE) at the same concentration. The anti-inflammatory effects of CP were evaluated using a lipopolysaccharide (LPS)-induced inflammation model in BALB/c mice. The immune-enhancing effects were assessed using a cyclophosphamide (CYP)-induced immunosuppression model. Protein and mRNA expressions of inflammatory and immune markers were analyzed through Western blotting and quantitative real-time PCR. CP significantly reduced LPS-induced pulmonary inflammation by decreasing interleukin (IL)-1β and cyclooxygenase-2 expression in lung tissues. In the CYP-induced model, CP treatment restored spleen and thymus weights, reversed reductions in immune cell counts, and increased TNF-α and IL-2 mRNA expression in the spleen. In conclusion, CP inhibits pulmonary inflammation by suppressing inflammatory mediators and enhances immune function by increasing immune-related indicators. This suggests that CP may have potential therapeutic applications for treating respiratory inflammation and related diseases.","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":"256-265"},"PeriodicalIF":1.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142931991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Phenylethanol Glycosides from Cistanche tubulosa Modulate the Gut Microbiota and Cecal Metabolites to Ameliorate Diabetic Nephropathy Induced by Streptozotocin Combined with High-Fat Diet in Rats. 肉苁蓉中的苯乙醇苷调节肠道微生物群和盲肠代谢物，改善链脲佐菌素联合高脂饮食诱导的大鼠糖尿病肾病

IF 1.7 3区农林科学

Journal of medicinal food Pub Date : 2025-03-01 Epub Date: 2024-10-14 DOI: 10.1089/jmf.2024.k.0175

Chong Ma, Bowei Ju, Jiangyun Liu, Limei Wen, Yao Zhao, Jianhua Yang, Junping Hu

{"title":"Phenylethanol Glycosides from Cistanche tubulosa Modulate the Gut Microbiota and Cecal Metabolites to Ameliorate Diabetic Nephropathy Induced by Streptozotocin Combined with High-Fat Diet in Rats.","authors":"Chong Ma, Bowei Ju, Jiangyun Liu, Limei Wen, Yao Zhao, Jianhua Yang, Junping Hu","doi":"10.1089/jmf.2024.k.0175","DOIUrl":"10.1089/jmf.2024.k.0175","url":null,"abstract":"Diabetic nephropathy (DN) is a prevalent complication and serious microvascular of diabetes mellitus. After previous studies, we found that phenylethanol glycosides (CPhGs) derived from Cistanche tubulosa (Schenk) Wight exerts antidiabetic and renoprotective effects. However, the effects of CPhGs on DN remain incompletely understood. The study aimed to examine the effects of CPhGs on DN in rats and explore the underlying mechanism involved. A DN rat model was established by streptozotocin (STZ) combined with a high-fat diet. Reagent kits were used to assess the extent to which CPhGs ameliorate hyperglycemia, insulin resistance (IR), renal dysfunction, kidney oxidative stress, and peripheral inflammation. Histology and immunohistochemical staining were used to detect the changes in renal tissue structure and the expression levels of α-smooth muscle actin (α-SMA) and collagen I. Furthermore, we analyzed the cecal contents of DN rats to investigate the effect of CPhGs on gut microbiota by using 16S rRNA sequencing and broad-spectrum metabolite profiling. The results showed that CPhGs demonstrated a range of advantageous outcomes in DN, encompassing the enhancement of kidney function and alleviation of hyperglycemia, IR, renal injury, oxidative stress, and peripheral inflammatory reactions. In addition, CPhGs regulated the abundance of the [Eubacterium]_coprostanoligenes_group, Oscillospiraceae_UCG-005, etc. to modulate the gut microbiota. CPhGs significantly upregulated the content of vitamin B6 and tyrosyl-tryptophan and downregulated histamine, L-methionine, etc. In summary, the therapeutic efficacy of CPhGs on DN rats may be achieved by modulating the gut microbiota and cecal metabolites to restore the metabolic disorders of vitamin B6, histidine, etc.","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":"219-231"},"PeriodicalIF":1.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142467872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hyperomocysteinemia in an Unselected Female Population: Incidence and Treatment Options. 高半胱氨酸血症在未选择的女性人群：发病率和治疗方案。

IF 1.7 3区农林科学

Journal of medicinal food Pub Date : 2025-03-01 Epub Date: 2024-11-29 DOI: 10.1089/jmf.2024.0214

Francesca Manganello, Giuseppe Mungo, Donatella Rettore, Esther Otaño Ruiz, Antonio Frungillo

{"title":"Hyperomocysteinemia in an Unselected Female Population: Incidence and Treatment Options.","authors":"Francesca Manganello, Giuseppe Mungo, Donatella Rettore, Esther Otaño Ruiz, Antonio Frungillo","doi":"10.1089/jmf.2024.0214","DOIUrl":"10.1089/jmf.2024.0214","url":null,"abstract":"Homocysteine (HCys) is a sulfur-containing amino acid involved in the conversion of methionine to cysteine. Elevated levels of HCys, known as hyperhomocysteinemia, have been associated with health risks, including cardiovascular and neurological disorders. This study examined the incidence of hyperhomocysteinemia in an unselected female population and evaluated the effectiveness of a Food for Special Medical Purposes (FSMPs), EUCIS PLUS, in reducing HCys levels.The study was divided into two phases: The first phase of the study, conducted at the Poliambulatorio Polimedica in Trebaseleghe (PD), evaluated the incidence of hyperhomocysteinemia in 181 women with an average age of 47.8 years; the second phase tested the effectiveness of EUCIS PLUS, a FSMPs, in reducing HCys levels in women with values above 10 µmol/L. During Phase 1, an incidence of hyperhomocysteinemia was observed in 81.2% of 181 women, with mean HCys levels of 15.4 µmol/L. Phase 2 involved treating 44 women with HCys >10 µmol/L using EUCIS PLUS, resulting in an average reduction of HCys levels by 36%, reaching 10.7 µmol/L after two months of treatment. Hyperomocysteinemia is an underdiagnosed risk condition. The results of this study highlight the importance of diagnosing and managing hyperhomocysteinemia and suggest that the FSMPs EUCIS PLUS can be an effective and well-tolerated therapeutic option.","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":"304-307"},"PeriodicalIF":1.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142750854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Aqueous Leaf Extract of Azadirachta indica Protects Against Gentamicin-Induced Kidney Injury via Decreases in Renal Function, Inflammation, and Apoptosis Markers. 印楝叶水提物通过降低肾功能、炎症和细胞凋亡标志物对庆大霉素所致肾损伤的保护作用。

IF 1.7 3区农林科学

Journal of medicinal food Pub Date : 2025-03-01 Epub Date: 2025-01-13 DOI: 10.1089/jmf.2023.0294

Oluwadare J Ogundipe, Abodunrin A Ojetola, Omolola F Akinpelu, Ibukun T Sossou, Ayomide Babatunde Ishola

{"title":"Aqueous Leaf Extract of Azadirachta indica Protects Against Gentamicin-Induced Kidney Injury via Decreases in Renal Function, Inflammation, and Apoptosis Markers.","authors":"Oluwadare J Ogundipe, Abodunrin A Ojetola, Omolola F Akinpelu, Ibukun T Sossou, Ayomide Babatunde Ishola","doi":"10.1089/jmf.2023.0294","DOIUrl":"10.1089/jmf.2023.0294","url":null,"abstract":"The effect of the aqueous extract of Azadirachta indica (AAI) on gentamicin (GEN)-induced kidney injury was investigated. The study involves 20 adult male Wistar rats (housed in four separate plastic cages) such that graded dosages of AAI were administered to the experimental group for 14 days per oral (PO) before exposure to GEN toxicity (100 mg/kg) for 1 week. At the end of the study, comparisons of some markers of renal functions, antioxidant status, and inflammatory and apoptotic markers were made between the control, GEN, and AAI-pretreated groups at P < .05. The result showed that GEN treatment caused a significant increase (P < .05) in body weight, kidney weight, urea, bilirubin, kidney injury molecule 1 (KIM 1), cystatin C, malondialdehyde (MDA), reduced glutathione (GSH), tumor necrotic factor alpha (TNF-α), interleukin-1 (IL-2), caspase-3, and B-cell lymphoma-2 associated X (BAX) as well as a significant decrease (P < .05) in superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (Gpx), and B-cell lymphoma (BCL)-2 level. Pre-treatment with graded doses of AAI caused a significant increase in urea, CAT, and GPx as well as a significant decrease (P < .05) in kidney weight, bilirubin, KIM 1, cystatin C, MDA, GSH, SOD, TNF-α, IL-2, caspase-3, BAX, and BCL-2. There was an appreciable difference in the kidney histology of the AAI pre-treated groups compared with the GEN. Hence, the extract has prophylactic potential in managing GEN-induced nephrotoxicity by decreasing the markers of renal function and inflammation and downregulating the markers of apoptosis.","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":"272-280"},"PeriodicalIF":1.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142971259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring the Effects of a Calming Herbal Tea Blend on Perioperative Anxiety: A Randomized Clinical Trial. 探索镇静草药茶对围术期焦虑的影响：随机临床试验

IF 1.7 3区农林科学

Journal of medicinal food Pub Date : 2025-03-01 Epub Date: 2024-11-08 DOI: 10.1089/jmf.2024.0170

Victória Cosel Zampieri, Itamar Luís Gonçalves, Ana Luiza Lira, Jamile Zeni, Geciane Toniazzo Backes, André Keng Wei Hsu

{"title":"Exploring the Effects of a Calming Herbal Tea Blend on Perioperative Anxiety: A Randomized Clinical Trial.","authors":"Victória Cosel Zampieri, Itamar Luís Gonçalves, Ana Luiza Lira, Jamile Zeni, Geciane Toniazzo Backes, André Keng Wei Hsu","doi":"10.1089/jmf.2024.0170","DOIUrl":"10.1089/jmf.2024.0170","url":null,"abstract":"This research aimed to explore the effectiveness of consuming a calming herbal tea blend, comprising Matricaria recutita, Passiflora incarnata L., and Pimpinella anisum L., in comparison to a placebo tea infused with lemon, to ascertain whether the herbal blend possesses anxiety-reducing properties capable of alleviating perioperative anxiety. The study adopted a clinical randomized, double-blind design and collected data from volunteers undergoing elective surgery at Hospital Unimed Erechim in the northern region of Rio Grande do Sul, Brazil. A total of 210 participants were enrolled and randomly allocated into two groups: one receiving the placebo tea and the other the sedative herbal tea. All participants completed a questionnaire postoperatively to assess anxiety levels, employing the adapted Portuguese version of the DASS-21 Scale (Depression, Anxiety, and Stress Scale). Results revealed no significant difference in anxiety levels between the group consuming the calming herbal tea and the group consuming the placebo tea. However, consumption of the anxiolytic herbal tea was associated with a notable increase in positive sentiments toward the surgical procedure (P = .0009). Furthermore, the study demonstrated that the DASS-21 questionnaire exhibited a preoperative profile comparable to the clinical scenarios depicted by the scale. Both the calming herbal tea and the placebo tea were found to effectively mitigate perioperative anxiety. This suggests that both options-soothing herbal tea and placebo tea-can be considered safe, efficacious, and pleasant methods for reducing preoperative fasting requirements.","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":"266-271"},"PeriodicalIF":1.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142604507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cinnamon (Cinnamomum zeylanicum) Aqueous Extract Regulates the Parameters of Metabolic Syndrome in a Model of Wistar Rats with a Diet High in Fat and Fructose. 肉桂（Cinnamomum zeylanicum）水提物对高脂高果糖Wistar大鼠代谢综合征模型的调节作用

IF 1.7 3区农林科学

Journal of medicinal food Pub Date : 2025-03-01 Epub Date: 2024-12-18 DOI: 10.1089/jmf.2024.0227

Gabriela Portillo-Rentería, Mario Del Toro-Equihua, Karmina Sánchez-Meza, Mónica Ríos-Silva, Julio-Alcaraz Siqueiros, Javier Uribarren, Yolitzy Cárdenas

{"title":"Cinnamon (Cinnamomum zeylanicum) Aqueous Extract Regulates the Parameters of Metabolic Syndrome in a Model of Wistar Rats with a Diet High in Fat and Fructose.","authors":"Gabriela Portillo-Rentería, Mario Del Toro-Equihua, Karmina Sánchez-Meza, Mónica Ríos-Silva, Julio-Alcaraz Siqueiros, Javier Uribarren, Yolitzy Cárdenas","doi":"10.1089/jmf.2024.0227","DOIUrl":"10.1089/jmf.2024.0227","url":null,"abstract":"To identify the effect of Cinnamomum zeylanicum (CZ) aqueous extract on glucose, triglycerides, high-density lipoprotein (HDL) cholesterol, and blood pressure in male Wistar rats, fed with a high-fat and high-fructose diet (HFFD). Twenty-four male Wistar rats were randomized into four groups: Healthy (fed with standard diet), Healthy + CZ (fed with standard diet + CZ extract), HFFD (fed with HFFD), HFFD+CZ, (fed with HFFD + CZ extract). The CZ aqueous extract was administered 100 mg/kg/day by oral gavage to each rat for 8 weeks. Blood samples, blood pressure, and weight were taken at the beginning and end of the experiment. The rats were euthanized after the experiment, according to the Mexican Official Standard NOM-062-ZOOO-1999. The administration of CZ aqueous extract significantly decreased glucose levels (F[1,18]=46.458, P < .001). The interaction between the type of diet and the extract had an effect on triglycerides (F[1,18]=14.93, P = .001), and systolic (F[1,18]=127, P < .001) and diastolic blood pressure levels (F[1,18]=146.13, P < .001) in male Wistar rats. HFFD, plus the administration of CZ aqueous extract over 8 weeks, significantly improved glucose, triglyceride, and systolic and diastolic blood pressure levels, regulating metabolic parameters in male Wistar rats.","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":"299-303"},"PeriodicalIF":1.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142846680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rosa Roxburghii Tratt Polysaccharides Prevent Alzheimer's Disease-Like Cognitive Dysfunctions and Pathology in Rats by Regulating the Microbiota-Gut-Brain Axis and Oxidative Stress.

IF 1.7 3区农林科学

Journal of medicinal food Pub Date : 2025-03-01 Epub Date: 2025-03-05 DOI: 10.1089/jmf.2024.k.0160

Mingyue Yin, Jiangjiang Peng, Ming Chen, Qingqing Zhan, Hui Zhong

{"title":"Rosa Roxburghii Tratt Polysaccharides Prevent Alzheimer's Disease-Like Cognitive Dysfunctions and Pathology in Rats by Regulating the Microbiota-Gut-Brain Axis and Oxidative Stress.","authors":"Mingyue Yin, Jiangjiang Peng, Ming Chen, Qingqing Zhan, Hui Zhong","doi":"10.1089/jmf.2024.k.0160","DOIUrl":"10.1089/jmf.2024.k.0160","url":null,"abstract":"The microbial-gut-brain axis and oxidative stress may be important to the pathogenesis of Alzheimer's disease (AD). Rosa roxburghii Tratt polysaccharides (RRTP) have a strong antioxidant effect and can affect the gut microbiota, and whether it can affect AD is unknown. So, AlCl3 and d-galactose were used to establish AD model rats, and RRTP was used as an intervention treatment. Morris water maze test was used to detect cognitive functions. The hippocampus was used to observe the pathological changes, and the cortex was used to measure antioxidant markers. The stool was collected for 16S rDNA sequencing. Morris water maze test showed that the learning ability and memory level of AD group rats were decreased, and RRTP intervention could mitigate the injury to a certain extent. In the AD group, hematoxylin-eosin staining revealed changes in the morphology of neurons, silver glycine staining revealed neurofibrillary tangles and Congo red staining revealed β-amyloid. RRTP could ameliorate the above changes to some extent. The results of superoxide dismutase, malondialdehyde, and glutathione peroxidase showed that the antioxidant capacity in the RRTP intervention group was significantly higher than that in the AD group. 16S rDNA sequencing results showed that there were differences in the species composition of gut microbiota, and the ratio of Firmicutes to Bacteroidetes in the AD group was decreased. After RRTP intervention, the proportion of Lactobacillus increased. In conclusion, RRTP may prevent AD pathology and cognitive functions in rats to a certain extent through the microbiota-gut-brain axis and oxidative stress.","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":"232-242"},"PeriodicalIF":1.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143557195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enzymatic Hydrolysate of Low-Molecular-Weight Soybean Peptides Suppresses Hydrogen Peroxide-Induced Apoptosis of Murine Myoblast C2C12 Cells Possibly via AMPK Activation.

IF 1.7 3区农林科学

Journal of medicinal food Pub Date : 2025-03-01 Epub Date: 2025-02-06 DOI: 10.1089/jmf.2024.k.0278

Wan Heo, Jeong Hoon Pan

{"title":"Enzymatic Hydrolysate of Low-Molecular-Weight Soybean Peptides Suppresses Hydrogen Peroxide-Induced Apoptosis of Murine Myoblast C2C12 Cells Possibly via AMPK Activation.","authors":"Wan Heo, Jeong Hoon Pan","doi":"10.1089/jmf.2024.k.0278","DOIUrl":"10.1089/jmf.2024.k.0278","url":null,"abstract":"Skeletal muscle health is essential for metabolic homeostasis, and dysregulated apoptosis in muscle cells can lead to muscle wasting and degenerative diseases. Although soybean-derived peptides are known for their bioactive properties, including antioxidant and anti-apoptotic effects, their impact on apoptosis regulation in skeletal muscle cells remains underexplored. This study aims to investigate the effects of low-molecular-weight soy peptide hydrolysate (SPH) on apoptosis and related markers in C2C12 myoblasts. SPH was prepared by enzymatic hydrolysis, and its antioxidant and anti-apoptotic activities were analyzed through in vitro assays (i.e., ABTS, DPPH). Cellular studies were used to evaluate SPH effects on ROS scavenging and apoptosis. Results show that SPH enhanced antioxidant activity, reduced ROS levels, and promoted cell proliferation in a dose-dependent manner. SPH notably decreased apoptosis under oxidative stress by down-regulating p53, c-Caspase-3, and Cyto-c, while promoting HO-1 expression, likely via AMPK activation. Importantly, SPH had no significant impact on inflammation-related proteins or MAPK activation. These findings suggest that SPH may have therapeutic potential against oxidative stress and apoptosis in muscle cells through intrinsic pathways, contributing to muscle health maintenance.","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":"294-298"},"PeriodicalIF":1.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143256097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Aruncus Dioicus Var. Kamtschaticus Extract Prevents Ocular Endoplasmic Reticulum Stress, Inflammation, and Oxidative Stress In Vitro.

IF 1.7 3区农林科学

Journal of medicinal food Pub Date : 2025-03-01 Epub Date: 2025-02-20 DOI: 10.1089/jmf.2024.k.0240

Sunyoung Jeong, Miae Doo, Kihun Sung, Young Jun Kim, Jong-Hwa Lee, Jung-Heun Ha

{"title":"Aruncus Dioicus Var. Kamtschaticus Extract Prevents Ocular Endoplasmic Reticulum Stress, Inflammation, and Oxidative Stress In Vitro.","authors":"Sunyoung Jeong, Miae Doo, Kihun Sung, Young Jun Kim, Jong-Hwa Lee, Jung-Heun Ha","doi":"10.1089/jmf.2024.k.0240","DOIUrl":"10.1089/jmf.2024.k.0240","url":null,"abstract":"The aim of this study was to determine the anti-inflammatory and anti-endoplasmic reticulum (ER) stress effects of Aruncus dioicus var. kamtschaticus (ADK) extract on ARPE-19 cells. Pretreatment with ADK effectively mitigated thapsigargin (Tg)-induced increases in vascular endothelial growth factor protein secretion and intracellular calcium levels. Furthermore, pretreatment with ADK suppressed ocular ER stress-related protein expression in a dose-dependent manner, inhibited the loss of tight junctions, and suppressed interleukin-6 gene expression. Moreover, ADK pretreatment significantly prevented lipopolysaccharide-inducible proinflammatory cytokine gene expression at the transcription level and the phosphorylation of proteins involved in the mitogen-activated protein kinase-nuclear factor kappa-light-chain-enhancer of activated B cells (NFκB) axis at the posttranslational level. Additionally, ADK extract enhanced antioxidant activity, as evidenced by increased heme oxygenase-1 protein expression and increased 2,2-diphenyl-1-picrylhydrazyl radical scavenging and ferric-reducing antioxidant power. In conclusion, ADK extract effectively protected ARPE-19 cells from ocular ER stress, inflammation, and oxidative stress, demonstrating its potential as a nutraceutical intervention for ocular diseases.","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":"281-293"},"PeriodicalIF":1.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143457909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0