Journal of medicinal food最新文献

{"title":"Lutein-Zeaxanthin Extract (XanMax^® 2002) Attenuates Oxidative Stress, Neuroinflammation, and Memory Deficits in H₂O₂-Exposed Neuro-2a Cells and Scopolamine-Induced Mice.","authors":"Yeonhwa Lee, Hyelim Kim, Jinhee Kim, Jeongjin Park, Yuri Gwon, Jinhak Kim, Priya Mk, Woojin Jun","doi":"10.1177/1096620X261430176","DOIUrl":"10.1177/1096620X261430176","url":null,"abstract":"<p><p>Age-related cognitive impairment is often linked to cholinergic dysfunction and increased oxidative stress. This study explored the neuroprotective potential of lutein-zeaxanthin extract (XanMax^® 2002; LZ) through both <i>in vitro</i> and <i>in vivo</i> approaches. <i>In vitro</i>, Neuro-2a cells exposed to hydrogen peroxide (H₂O₂) were treated with LZ (5-20 μg/mL), leading to decreased expression of apoptosis-related proteins. <i>In vivo</i>, memory impairment was induced by scopolamine in C57BL/6N mice, followed by oral administration of LZ (4 or 8 mg/kg) for 4 weeks. Behavioral assessments-including the Morris water maze, Y-maze, and passive avoidance tests-demonstrated significant improvements in spatial learning, working memory, and memory retention in LZ-treated groups, particularly at the higher dose. Biochemical analysis revealed increased acetylcholine levels, reduced acetylcholinesterase activity, and downregulation of oxidative stress and neuroinflammatory markers in brain tissue. Moreover, LZ supplementation upregulated genes associated with synaptic function and memory. The cognitive-enhancing effects of LZ were comparable with those of donepezil. These findings suggest that LZ may exert neuroprotective effects through antioxidant and anti-inflammatory mechanisms and are a potential dietary intervention for cognitive decline.</p>","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":"268-278"},"PeriodicalIF":2.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147574355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preventive Effect of Standardized <i>Lespedeza cuneata</i> Extract on Dexamethasone-Induced Muscle Atrophy in C57BL/6N Mice.","authors":"Minseong Kang, Eun Jin Kim, Taeuk Kim, Yeeun Kim, Dahye Kang, Changhee Kim, Jae-Kwan Hwang","doi":"10.1177/1096620X261428023","DOIUrl":"10.1177/1096620X261428023","url":null,"abstract":"<p><p>Muscle atrophy, characterized by a decline in muscle mass and function, results from an imbalance between protein synthesis and degradation. This study explored the effects of standardized <i>Lespedeza cuneata</i> extract (LCE) on dexamethasone (DEX)-induced muscle atrophy. The mice were orally administered LCE for 17 days. Starting on day 7 of oral administration, DEX was intraperitoneally injected into mice daily for 10 days to induce muscle atrophy. LCE treatment significantly improved grip strength by 22.27% and 33.16% and increased muscle volume by 17.47% and 23.00% at doses of 250 and 500 mg/kg/day, respectively, compared with the DEX group, and also markedly restored hind limb muscle weight. At the molecular level, LCE decreased the mRNA expression of myostatin, muscle ring finger1, and muscle atrophy F-box, which are involved in proteolysis, by inhibiting forkhead box O3a translocation. Furthermore, LCE activated the mammalian target of rapamycin pathway and upregulated myogenesis-related genes via the phosphoinositide 3-kinase/Akt pathway. It also reduced nuclear factor kappa B-mediated inflammatory cytokines, including tumor necrosis factor alpha and interleukin-6. Thus, LCE may serve as a functional food ingredient that prevents muscle atrophy.</p>","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":"247-256"},"PeriodicalIF":2.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147390216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cinnamyl Alcohol Attenuates Osteoarthritis Progression via PIGR-Mediated Regulation of Chondrocyte Senescence and Cartilage Homeostasis.","authors":"Qi Zhu, Qingxia You, Jiaojiao Deng, Hongting Tang, Yuhan Hu, Yuanmeng Liao, Ying Miao","doi":"10.1177/1096620X261430173","DOIUrl":"10.1177/1096620X261430173","url":null,"abstract":"<p><p>Osteoarthritis (OA) is characterized by inflammation-driven chondrocyte senescence and extracellular-matrix degradation. However, the molecular mechanisms linking inflammatory stress to chondrocyte aging remain poorly understood. Here, we identify cinnamyl alcohol (CA) as a natural small-molecule compound that attenuates OA progression through polymeric immunoglobulin receptor (PIGR)-mediated signaling <i>in vitro</i>. CA reduced inflammatory cytokine production, suppressed senescence-associated secretory phenotype gene expression, and preserved cartilage homeostasis in lipopolysaccharide- or interleukin-1β-stimulated chondrocytes. In a destabilization-of-the-medial-meniscus mouse model, intra-articular CA administration markedly alleviated cartilage degeneration and matrix loss. Integrating network pharmacology, molecular docking, and mass-spectrometry-based proteomic profiling, we identified PIGR as a convergent target of CA, validated by limited proteolysis (drug affinity responsive target stability) and loss-of-function assays. PIGR silencing abolished CA's antisenescent and cartilage-protective effects, confirming its essential role. Mechanistically, CA restored PIGR expression to modulate inflammatory signaling and maintain chondrocyte phenotype stability. These findings uncover a previously unrecognized CA-PIGR axis that couples inflammatory stress to cartilage aging and suggest CA as a promising natural therapeutic candidate for OA management.</p>","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":"279-293"},"PeriodicalIF":2.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147717035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of <i>Lactiplantibacillus Plantarum</i> KABP051 Probiotic on Body Composition, Microbiome and Mood in Healthy Overweight Adults.","authors":"Shawn Talbott, Bret Stephens, Julie Talbott, Marc Oddou, Aoki Fumiki","doi":"10.1177/1096620X261448041","DOIUrl":"https://doi.org/10.1177/1096620X261448041","url":null,"abstract":"<p><p>Obesity and mental health disorders are among the greatest public health challenges of the 21st century. Interestingly, an altered microbiome profile has been associated with both conditions. The aim of this randomized, double-blind, placebo-controlled clinical trial was to evaluate the effects of dietary supplementation with a specific probiotic strain (<i>Lactiplantibacillus plantarum</i> KABP051) on body composition and gut microbiome balance, together with measures of mood state, in a population of healthy overweight subjects. Sixty healthy, moderately stressed, nondepressed and overweight or obese volunteers were supplemented for 12 weeks with probiotic (<i>L. plantarum</i> KABP051; 1 billion colony forming units/day) or placebo (microcrystalline cellulose). The KABP051 group experienced significantly greater improvements compared with placebo on body composition measurements, including a reduction in body weight and waist circumference, which decreased in 1.97 ± 0.77 (mean ± SE) kg and 2.15 ± 0.81 (mean ± SE) cm versus placebo at the end of the intervention (both <i>P</i> < .05, mixed model for repeated measures [MMRM] and <i>post-hoc</i> analysis). Microbiome composition improved in KABP051 group, with significant increase in the relative abundance of <i>Lactiplantibacillus</i> spp. versus placebo. Body fat percentage, profile of mood states fatigue, and confusion sub-scores showed a global trend toward improvement compared with placebo, with the change at 12 weeks being significant in the three measurements in <i>post-hoc</i> analysis (<i>P</i> = .015, <i>P</i> = .014, and <i>P</i> = .016, respectively). No serious adverse events were registered during the intervention period. These results suggest that a specific strain of probiotic bacteria (<i>L. plantarum</i> KABP051) may have both metabolic and psychobiotic effects and may be beneficial for enhancing weight loss and body composition, improving energy (less fatigue) and mood levels while embarking on a healthy lifestyle regimen. ClinicalTrials.gov identifier: NCT06808061.</p>","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":"1096620X261448041"},"PeriodicalIF":2.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147816098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modulation of Antioxidant and Anti-Inflammatory Response in the Eyes of CKD Animals Supplemented with Larch Arabinogalactan.","authors":"Pedro Henrique Alves Reis, Isabela de Paula Destro, Ingrid Bertollini Lamy, Giuliana Petri, Estella Freitas Silvestri, Isabella Dudjak Rosa Trufelli, Beatriz da Costa Aguiar Alves, Vagner Loduca Lima, Glaucia Luciano da Veiga, Fernando Luiz Affonso Fonseca","doi":"10.1177/1096620X261447993","DOIUrl":"https://doi.org/10.1177/1096620X261447993","url":null,"abstract":"<p><p>Chronic kidney disease (CKD) is a systemic condition associated with inflammation and oxidative stress, affecting organs beyond the kidneys. Although rarely emphasized, the eyes may also be affected but underlying molecular mechanisms remain largely unexplored. The gut-kidney and gut-eye axes are emerging as therapeutic targets with prebiotics like ResistAid®-a Larch Arabinogalactan (LAG) supplement with antioxidant and immunomodulatory effects-showing promise through gut microbiota modulation. This study assessed ResistAid®'s effects on ocular gene expression in a CKD rat model. Twenty four Wistar rats were assigned to Sham (S), Sham + Treatment (ST), Nephrectomized (N), Nephrectomized + Treatment (NT) (<i>n</i> = 6 each). CKD was induced by 5/6 nephrectomy. The treatment was administered via gavage for 30 days at a dose of 5.35 mg/day, adapted from human recommendations. At day 30, blood and tissues were collected. Expression of antioxidant enzymes (<i>Cat, Sod1, Gpx1, Gpx4</i>) and other genes (<i>Nfe2l2, Nfκb1, Timp3, Hif-1α, Kim1, Klotho</i>) was analyzed by qPCR. Biochemical and well-being assessments were also conducted. Nephrectomy, regardless of treatment, increased <i>Sod1</i> and <i>Hif1ɑ</i> expression in eye and blood; Specific to NT animals, ocular <i>Gpx1</i>, <i>Gpx4</i> and <i>Nfe2l2</i> expressions were markedly elevated when compared with N animals and blood <i>Kim1</i> and ocular <i>Nfκb1</i> expressions were not elevated, differing from N animals. No significant changes were observed between the S and ST groups. CKD induces systemic oxidative and inflammatory responses. ResistAid® partially mitigated these effects in blood and eye, suggesting systemic and local benefits, possibly via gut microbiota modulation.</p>","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":"1096620X261447993"},"PeriodicalIF":2.0,"publicationDate":"2026-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147774241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Melphalan's Effect on Testicular Prepubertal Rats: Induction of Autophagy and Apoptosis, Modulated by the Potential of Chrysin.","authors":"Amir-Hossein Ebadi, Maryam Moghimian, Seyed-Hossein Abtahi-Evari, Zahra Saadatian, Seyed-Hasan Hosseini, Malihe Soltani","doi":"10.1177/1096620X261434448","DOIUrl":"https://doi.org/10.1177/1096620X261434448","url":null,"abstract":"<p><p>Melphalan, a widely used alkylating chemotherapeutic agent, is known to cause gonadotoxicity, particularly affecting spermatogenesis and steroidogenesis. This study investigated the protective effects of chrysin, a flavonoid with antioxidant and antiapoptotic properties, on melphalan-induced testicular damage in immature male rats. Forty-eight prepubertal Wistar rats were divided into six groups receiving melphalan (0.5 mg/kg/day, intraperitoneally), chrysin (50 or 75 mg/kg/day, orally), or combinations thereof. Treatment spanned 30 days, covering the prepubertal to pubertal transition. Melphalan exposure significantly reduced testosterone levels, disrupted spermatogenesis, and increased oxidative stress, as indicated by elevated malondialdehyde and decreased glutathione peroxidase levels. Gene expression analysis revealed marked upregulation of autophagy (LC3β, Beclin-1, Atg5, Atg7, Atg12) and apoptosis (BAX, caspase-3) markers, alongside downregulation of the antiapoptotic gene BCL2. Histological analysis showed severe damage to seminiferous tubules and reduced Johnsen scores. Chrysin coadministration, particularly at 75 mg/kg, significantly ameliorated these effects by restoring antioxidant capacity, reducing expression of cell death-related genes, and improving testicular structure and hormone levels. These findings demonstrate that chrysin mitigates melphalan-induced gonadotoxicity through modulation of oxidative stress, apoptosis, and autophagy pathways. Chrysin's dose-dependent protective effects highlight its potential as a natural therapeutic agent to preserve reproductive function in individuals undergoing chemotherapy during prepuberty.</p>","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":"1096620X261434448"},"PeriodicalIF":2.0,"publicationDate":"2026-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147774205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>Retraction:</i> Therapeutic Effect of <i>Acer tegmentosum</i> Maxim Twig Extract in Bile Duct Ligation-Induced Acute Cholestasis in Mice.","authors":"","doi":"10.1177/1096620X261443792","DOIUrl":"https://doi.org/10.1177/1096620X261443792","url":null,"abstract":"","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":"1096620X261443792"},"PeriodicalIF":2.0,"publicationDate":"2026-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147774218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Red Ginseng Oil Enhances Lipid Metabolism and Liver Function in HepG2 Cells and Hypercholesterolemic Rats.","authors":"Soo-Jeung Park, Minhee Lee, Seong-Hoo Park, Hyelim Kim, JiYeon Park, Han Ol Kwon, Jong Han Kim, Jeongmin Lee","doi":"10.1177/1096620X261438295","DOIUrl":"https://doi.org/10.1177/1096620X261438295","url":null,"abstract":"<p><p>Hypercholesterolemia is a major risk factor for cardiovascular disease, necessitating the development of effective and safe lipid-lowering interventions. This study evaluated the antihypercholesterolemic effects of KGC11<i>o</i>, a red ginseng oil obtained via supercritical fluid extraction, using both HepG2 cells and a high-fat/high-cholesterol diet-induced hypercholesterolemic rat model. KGC11<i>o</i> treatment significantly improved serum and hepatic lipid profiles, reduced markers of liver injury, and enhanced fecal cholesterol excretion. At the molecular level, KGC11<i>o</i> modulated the expression of key genes involved in cholesterol biosynthesis (3-hydroxy-3-methylglutaryl-CoA reductase), esterification (acyl-CoA:cholesterol acyltransferase), transport (CETP, LPL), and catabolism (LCAT, cholesterol 7α-hydroxylase). Collectively, these findings suggest that KGC11<i>o</i> may serve as a safe, food-derived functional ingredient with potential benefits for the management of hypercholesterolemia and related metabolic disorders. Further studies are warranted to elucidate its molecular mechanisms and to confirm its clinical efficacy.</p>","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":"1096620X261438295"},"PeriodicalIF":2.0,"publicationDate":"2026-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147690548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inulin, Containing Frutco-Oligosaccharides, and Generalized Anxiety Disorder 7-Item Scale Scores in College Students.","authors":"Spencer Herkes, Judith M Lukaszuk, David A Walker, Masih Shokrani, Matthew Stark","doi":"10.1177/1096620X261421081","DOIUrl":"https://doi.org/10.1177/1096620X261421081","url":null,"abstract":"<p><p>This study was conducted to determine the effects of fructo-oligosaccharide (FOS) inulin on anxiety symptoms in college students. Forty million adults in the United States suffer from anxiety. Previous studies have viewed gut microbiota and its potential link to anxiety in both humans and mice. However, no previous studies focused on the effect of FOS inulin on college students. Fourteen subjects received 4.9 g per day of FOS inulin as the treatment (TX) or no supplement as the control (CON) for 28 days. Both the TX and CON groups were given the Generalized Anxiety Disorder 7-Item Scale (GAD-7) on days 1 and 28. Both groups were also given a 3-day food log at the beginning of the experiment and otherwise maintained their regular diet. Results showed a statistically significant decrease in median GAD-7 scores in both groups (<i>P</i> = .017, <i>r</i> = .637 and <i>P</i> = .042, <i>r</i> = .587 for the TX and CON groups, respectively). However, when comparing the GAD-7 scores between groups, no statistically significant results were found. FOS inulin supplementation did not alleviate anxiety symptoms in college students participating in this study.</p>","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":"1096620X261421081"},"PeriodicalIF":2.0,"publicationDate":"2026-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147690587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hydroxypropyl Methylcellulose as a Functional Dietary Fiber Preserves Intestinal Barrier Integrity via NF-κB Modulation Under Inflammatory Conditions.","authors":"Mingyeong Kim, Chi Heung Cho, Sera Kim, Mi-Jin Oh, Ho-Young Park, In-Wook Choi, Sang-Hoon Lee","doi":"10.1177/1096620X261430170","DOIUrl":"10.1177/1096620X261430170","url":null,"abstract":"<p><p>Intestinal epithelial barrier integrity is crucial for maintaining gut homeostasis and preventing luminal inflammation. Disruption of tight junctions (TJs) by pro-inflammatory cytokines such as tumor necrosis factor-α and interferon-γ contributes to barrier dysfunction, a hallmark of disorders like inflammatory bowel disease. In this study, we investigated the protective effects of hydroxypropyl methylcellulose (HPMC), a widely used excipient and dietary fiber, against cytokine-induced epithelial barrier dysfunction in Caco-2 cell monolayers. HPMC treatment preserved transepithelial electrical resistance, reduced paracellular leakage of FITC-dextran, and significantly suppressed the secretion of inflammatory mediators, including interleukin (IL)-8, IL-1β, IL-6, and monocyte chemoattractant protein (MCP)-1. Furthermore, HPMC restored the expression and localization of TJ proteins zonula occludens-1 and occludin and attenuated NF-κB activation by inhibiting IκBα phosphorylation and subsequent nuclear translocation. These findings indicate that HPMC counteracts cytokine-driven epithelial barrier disruption through coordinated anti-inflammatory and barrier-stabilizing actions. Collectively, our results demonstrate that noncytotoxic HPMC (12.5-100 μg/mL) has potential as a safe pharmaceutical excipient and functional dietary fiber capable of supporting intestinal health under inflammatory conditions.</p>","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":"222-231"},"PeriodicalIF":2.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147512849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}