Journal of medicinal food最新文献

{"title":"Epigallocatechin-3-Gallate and Glabridin Synergistically Inhibited Melanogenesis by Molecular Interaction and the MicroRNA-Microphthalmia-Related Transcription Factor Pathway.","authors":"Jingwu Song, Zhaowen Chen, Tongtong Li, Weijia Xu, Guan Feng, Jian Ge","doi":"10.1089/jmf.2024.k.0274","DOIUrl":"10.1089/jmf.2024.k.0274","url":null,"abstract":"<p><p>Epigallocatechin-3-gallate (EGCG) and glabridin (GLA) are two phytochemicals derived from homologous plants used for medicine and food that have demonstrated efficacy in inhibiting excessive production of melanin and promoting skin whitening properties. However, it is unknown whether EGCG and GLA can synergistically inhibit melanogenesis. The aim of this study was to explore the effects of the combination of EGCG and GLA on the expression and activity of microphthalmia-related transcription factor (MITF) and to reveal the mechanism of the synergistic treatment with EGCG and GLA on excessive melanin deposition. This study used B16F10 cells to screen for the synergistic effect on melanin deposition and determined the best ratio of EGCG and GLA. Dual-luciferase reported gene assays were used to explore whether GLA and EGCG could regulate the mRNA level of MITF. Molecular docking and molecular dynamics simulation were used to explain the synergistic interaction of EGCG and GLA with MITF, and then Masson-Fontana and hematoxylin-eosin were used to observe the skin changes of mice. The results showed that the combination of EGCG and GLA could synergistically regulate MITF and thus inhibit melanogenesis by modulating microRNA expression. EGCG and GLA were also able to synergistically interact with MITF to inhibit excessive melanogenesis. [Figure: see text].</p>","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":"553-567"},"PeriodicalIF":1.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144127934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oral Supplements and Photoprotection: A Systematic Review.","authors":"Nicole Natarelli, Shaliz Aflatooni, Kaylee Stankiewicz, Lilia Correa-Selm, Raja K Sivamani","doi":"10.1089/jmf.2024.0023","DOIUrl":"10.1089/jmf.2024.0023","url":null,"abstract":"<p><p>Photoprotective effects of various nutritional components and supplements have been demonstrated in animal and <i>in vitro</i> studies. The objective of this systematic review is to assess the photoprotective effects of various dietary supplements. A systematic review of studies assessing dietary supplements on photoprotective outcomes was performed. Human studies were retrieved from PubMed, Embase, and Cochrane in February 2023. Supplement keywords included \"dietary supplements,\" \"vitamins,\" \"minerals,\" \"carotenoids,\" \"lutein,\" \"isoflavones,\" \"polyphenols,\" \"<i>Polypodium leucotomos</i>,\" \"heliocare,\" \"herbal medicine,\" \"probiotics,\" \"prebiotics,\" \"astaxanthin,\" \"rosmarinic acid,\" \"botanical,\" and \"herb,\" and outcome keywords included \"photoprotection,\" \"ultraviolet rays,\" UVA,\" \"UVB,\" and \"blue light.\" A total of 47 studies were included in the systematic review. Studied supplements included carotenoids, polyphenols, <i>Polypodium leucotomos</i> (PL), melon concentrate, vitamins, coenzyme Q, squalene, and omega-3 and omega-6 fatty acids. Some studies evaluated mixed supplementation and incorporated other active ingredients such as selenium and probiotics. The greatest evidence of photoprotection exists for polyphenols, carotenoid-based, and PL supplementation. While flavanol supplementation exhibited dose-dependency, dose-dependency could not be consistently demonstrated for polyphenol supplementation. The weakest evidence exists for photoprotective effects of isolated vitamin or coenzyme Q supplementation. Dietary supplements may promote enhanced photoprotection, although current evidence is limited by small sample size and short duration. Supplementation with photoprotective active ingredients may be especially favorable for individuals with predisposed ultraviolet sensitivity, such as those with polymorphic light eruption. Future research is necessary to determine optimal dosing and supplementation duration for intended photoprotective outcomes.</p>","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":"519-541"},"PeriodicalIF":1.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142971281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Therapeutic Effects of Edible Desert Truffle Specie (<i>Tirmania nivea</i>) on Hepatogastric Toxicity Induced by Aspirin Treatment in Rats.","authors":"Dorra Ben Said, Ridha Ben Ali, Ezzedine Nouiri, Mohamed Bassem Hammami, Michelle-Véronique Elmay, Sihem El Aidli","doi":"10.1089/jmf.2023.0202","DOIUrl":"10.1089/jmf.2023.0202","url":null,"abstract":"<p><p>Edible mushrooms (<i>Tirmania nivea</i>: Desert truffle specie) are a nutrient-dense source of flavonoids, proteins, fatty acids, minerals, and vitamins. The current study aimed to evaluate the curative effect of an aqueous extract of <i>T. nivea</i> ascocarps against aspirin-induced gastric, liver, and kidney injuries in rats. Hepatogastric disorders induced by aspirin at a dose of 10 mg/kg body weight (BW) treatment in rats and treated with aqueous extract of <i>T. nivea</i> at different doses 25, 50, and 100 mg/kg BW). <i>T. nivea</i> aqueous extract liquid chromatography-mass spectroscopy analysis showed several actives biomolecules such as quinic acid, syringic acid, O-coumaric acid, chlorogenic acid, caffeic acid, luteolin-7-O-glucoside, 4-O-caffeoylquinic acid, and vitamin C. The 1,1-diphenyl-2-picrylhydrazyl radical-scavenging activity revealed significant antioxidant activity (EC₅₀% = 0.6 mg/mL). Aspirin administration caused severe injuries with linear hemorrhagic lesions. The treatment with <i>T. nivea</i> extract ameliorates gastric mucosal structure. The aspirin treatment caused significant increase of alanine aminotransferase and aspartate aminotransferase activities. In curative objective, <i>T. nivea</i> extract significantly corrected the disturbance of liver parameters. Rats given aspirin showed altered liver architecture, apoptosis, and inflammation; in contrast, sections of liver tissue in the rats treated with <i>T. nivea</i> extract at 25 mg/(kg·day) after aspirin administration showed normal liver architecture. A normal architecture was restored once the treatment dose was increased to 50 mg/kg. After 14 days of treatment with 100 mg/(kg·day) of <i>T. nivea</i> extract, aspirin disruptions completely collapse with development of steatosis. On contrary, one week of rat's treatment by aspirin succeed by 2 weeks without any treatment, the histological examination of the kidney showed a dilated capillary and altered Bellini tubes. Normal renal architecture was observed at a dosage of 25 mg/(kg·day) of <i>T. nivea</i>. Extract from <i>T. nivea</i> restored the renal disturbances caused by aspirin.</p>","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":"595-602"},"PeriodicalIF":1.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143996088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond Performance: Creatine Delays the Onset of Fatigue and Augments Muscle Regeneration in Doxorubicin-Induced Myotoxicity.","authors":"Salaheddin Sharif, Raquel Busekrus, Brandon Jones, David Hydock","doi":"10.1089/jmf.2022.0070","DOIUrl":"10.1089/jmf.2022.0070","url":null,"abstract":"<p><p>Doxorubicin (Dox) impairs myogenic regulatory factor (MRF) expression and induces myotoxicity, and previous studies showed that creatine (Cr) supplementation before Dox treatment prevents forelimb grip (FG) force reduction and alleviates fatigue. However, Cr supplementation's effects on MRFs with Dox treatment are not well known. The effects of Cr on skeletal muscle function and MRFs 1, 3, and 5 days following Dox treatment are investigated. Male rats were randomly assigned to the control saline group (Con+Sal), control doxorubicin group (Con+Dox), standard Cr diet (2% Cr for 4 weeks) doxorubicin group (Cr1+Dox), or Cr loading diet (4% Cr for 1 week followed by 2% Cr 3 weeks) doxorubicin group (Cr2+Dox). After 4 weeks of feeding, Dox groups received 15 mg/kg Dox and Sal received saline as a placebo. At 1, 3, and 5 days postinjection, FG force and <i>ex vivo</i> muscle function of the extensor digitorum longus (EDL) were measured. Myf-6, Myf-5, MyoD, and myogenin expression was analyzed using Western blotting. At 5 days postinjection, Con+Dox, Cr1+Dox, and Cr2+Dox groups had significantly lower FG force than Con+Sal (<i>P</i> < .05). EDL maximal twitch force of Con+Dox, Cr1+Dox, and Cr2+Dox groups was significantly lower than Con+Sal (<i>P</i> < .05) at 3 and 5 days postinjection. At 1 and 5 days postinjection, Cr alleviated Dox-induced fatigue in EDL muscle. At 1-day postinjection, Cr1+Dox, and Cr2+Dox had significantly higher Myf-6 and myogenin expression than the Con+Sal group, and Cr2+Dox group had significantly higher Myf-5 and MyoD compared with the Con+Sal group (<i>P</i> < .05). Cr supplementation attenuated fatigue and enhanced early muscle repair and regeneration in Dox-induced myotoxicity.</p>","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":"625-637"},"PeriodicalIF":1.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144127932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative Study of Two <i>Erythronium sibiricum</i> Bulb Polysaccharide Fractions in Alleviating Airway Remodeling by Affecting Autophagy and Apoptosis.","authors":"Shan Shan Gao, Yue Xuan Cheng, Yue Zhou, Rong Chang Liu, Xue Li, Xiang Yun Xie, Chunli Chen","doi":"10.1089/jmf.2024.k.0231","DOIUrl":"10.1089/jmf.2024.k.0231","url":null,"abstract":"<p><p><i>Erythronium sibiricum</i> (<i>E. sibiricum</i>), which is an indigenous herb in China, is gathered and consumed by nomads in Xinjiang due to its medicinal value. Only a few studies have evaluated its possible pharmacological activity. This study aims to examine and compare the ways in which two <i>E. sibiricum</i> bulb polysaccharide fractions (ESBP and E1P) alleviate airway remodeling based on apoptosis and autophagy. In a mouse model of chronic asthma produced by ovalbumin, the anti-asthmatic effects of E1P and ESBP were investigated. The expression levels of the proteins linked to autophagy and apoptosis (cleaved-caspase 3, Beclin1, LC3B, Bad, and Bax) as well as the activity of the PI3K/Akt/mTOR signaling pathway were assessed. Airway remodeling was alleviated by E1P and ESBP. While E1P could only prevent the increase in PI3K, ESBP was capable of inhibiting the PI3K/Akt/mTOR signaling pathway. Furthermore, ESBP decreased the levels of cleaved-caspase 3, Beclin1, LC3B, Bad, and Bax protein expressions. By modifying signaling pathways linked to autophagy and apoptosis, <i>E. sibiricum</i> bulb polysaccharides successfully improved the airway remodeling of asthma. Additionally, ESBP exhibited more potent inhibitory effects on asthmatic defective autophagy than E1P.</p>","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":"574-583"},"PeriodicalIF":1.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143730477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Combined Turmeric and Allspice Supplement Improves Metabolic Health in Obese Rats by Reducing Carbohydrate and Lipid Absorption.","authors":"Jazel Barragan-Zuñiga, Mayra Denise Herrera, Luis E Simental-Mendía, Alejandro Zamilpa, Dulce Lourdes Morales-Ferra, Gerardo Martínez-Aguilar, José Salas-Pacheco, Claudia I Gamboa-Gómez","doi":"10.1089/jmf.2024.0024","DOIUrl":"10.1089/jmf.2024.0024","url":null,"abstract":"<p><p>The objective of this study is to assess the impact of a combined turmeric (<i>Curcuma longa</i> L.) and allspice (<i>Pimenta dioica</i> L. Merril) supplement (TAS), on obesity, hypertriglyceridemia, hyperglycemia, and insulin resistance through inhibition of carbohydrate and lipid absorption. In vitro assessments demonstrated that TAS inhibits key enzymes implicated in the carbohydrate and lipid absorption. Oral starch and lipid tolerance tests showed that combined supplement reduced lipid (∼47% TAS) and carbohydrate absorption (∼33%) compared to the negative control. In a 36-week diet-induced obesity model, intervention with TAS was found that reduced body weight gain (∼18%), lower triglycerides (∼35%), and fasting glucose levels (∼14%) compared to obese control. Furthermore, TAS-treated rats showed reduced oral glucose tolerance test values (∼25%), insulin levels (∼14%), and insulin resistance (∼14%). Our results suggest that TAS enhances carbohydrate and lipid absorption while effectively improving hypertriglyceridemia, hyperglycemia, and insulin resistance in obese rats. [Figure: see text].</p>","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":"603-614"},"PeriodicalIF":1.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143996741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Supplementation Containing Bromelain on the Side Effects of Oncological Treatment: Systematic Review.","authors":"Irislene Costa Pereira, Raquel Barros Passos, Camila de Meneses Caetano Viana, Isabele Frazão Mascarenhas, Glauto Tuquarre de Melo Nascimento, Felipe Cavalcanti Carneiro da Silva, João Marcelo de Castro E Sousa, Francisco Leonardo Torres-Leal","doi":"10.1089/jmf.2023.0027","DOIUrl":"10.1089/jmf.2023.0027","url":null,"abstract":"<p><p>Systemic therapies for the treatment of cancer collaborate to reduce cancer progression and have been used for decades. However, despite the clinical benefits, its long-term use is associated with toxicity, promoting important side effects that can compromise the quality of life. Enzyme supplementation has been pointed out as a therapeutic potential in several diseases. Bromelain is an enzyme complex that regulates pathways associated with inflammation. This review aims to evaluate the use of bromelain-containing supplements to improve the side effects of cancer treatment. This systematic review was developed in PubMed, Web of Science, and Cochrane Library, using the terms: Cancer AND Bromelain. 239 studies were retrieved, and only three met our objective. In general, it was possible to observe that supplementation was able to reduce side effects of adjuvant hormone therapy and chemotherapy, such as mucosal dryness, arthralgia, and peripheral neuropathy induced by chemotherapy.</p>","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":"513-518"},"PeriodicalIF":1.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144078473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phytochemical Properties of (-)-Epicatechin Promotes Bone Regeneration Inducing Osteogenic Markers Expression BMP2, SPARC, and RUNX2 in Mesenchymal Stem Cells <i>In Vitro</i>.","authors":"Icela Palma-Lara, Claudia Camelia Calzada-Mendoza, Elvia Mera-Jiménez, Ernesto Romero López, Juan Luis Amaya-Espinoza, Alberto Parra-Barrera, Gisela Gutiérrez-Iglesias","doi":"10.1089/jmf.2024.0256","DOIUrl":"https://doi.org/10.1089/jmf.2024.0256","url":null,"abstract":"<p><p>(-)-Epicatechin (EC), a bioactive compound found in the plant kingdom contained in beans from the cacao tree, and other vegetables, has high flavonoid content. Traditionally consumed as chocolate, presents various benefits in human health. Many flavonoids have demonstrated therapeutic effects against osteoporosis by enhancing bone density; however, the specific impact of EC on bone regeneration remains unknown. Since bone regeneration involves a small group of responsive stem cells, we investigated the flavonoids' effects on key bone precursors like mesenchymal stem cells (MSCs). We used a conventional osteogenic medium alone or combined with different EC concentrations. Our study revealed that low concentrations of EC could enhance the expression of osteogenic genes when combined with low concentrations of osteogenic medium and induced the highest differentiation of human MSCs compared with pharmacological concentrations. So, the increase in the expression of osteoblastic marker genes such as bone morphogenetic protein 2, Runt-related transcription factor 2, and secreted protein acidic and cysteine rich agreed with an increase in cellular calcium deposits. Therefore, we conclude that the natural flavonol (-)-EC improved the expression of genes involved in bone regeneration and could potentially serve as an adjunctive therapy for bone loss diseases.</p>","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144183576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>Abelmoschus manihot</i> Flower Extract Retards Platelet-Derived Growth Factor-BB-Stimulated Proliferation and Migration in Vascular Smooth Muscle Cells by Inhibiting the MAPK/NF-κB Pathway and Matrix Metalloproteinase Expressions.","authors":"Chin-Feng Hsuan, Yi-Ting Kuo, Tzu-Hsien Chang, Ya-Ling Chen, Hsin-Ya Houng, Natasha Chang, Sabrina Chang, Chi-Chang Chang, Jer-Yiing Houng","doi":"10.1089/jmf.2024.k.0263","DOIUrl":"https://doi.org/10.1089/jmf.2024.k.0263","url":null,"abstract":"<p><p>Vascular smooth muscle cells (VSMCs) are vital to the structure of blood vessel walls. Under abnormal vascular conditions, VSMCs undergo a phenotypic transformation, leading to enhanced cell proliferation, migration, and matrix synthesis. This contributes to the development of vascular diseases such as atherosclerosis, arteriosclerosis, and restenosis. During this process, platelet-derived growth factor (PDGF)-BB is a key inducer of the VSMC phenotypic transformation. <i>Abelmoschus manihot</i> (L.) Medic flower (AMf) is known for its rich nutritional value and traditional medicinal uses. Its extract has been clinically used to treat kidney diseases, but its impact on VSMCs has not been documented. This study explored the inhibitory effects of AMf ethanol extract (AME), hot water extract (AMW), and supercritical CO₂ extract (AMS), and their five indicator components (rutin, quercetin, isoquercitrin, myricetin, and hyperoside) on PDGF-BB-stimulated proliferation and migration using a rat aortic smooth muscle cell (RASMC) model. Both AME and AMS showed a significant dose-dependent inhibition of PDGF-BB-induced RASMC proliferation and migration, with AME being more effective than AMS. In contrast, AMW had no effect. The five indicator compounds also showed excellent inhibitory effects. AME treatment effectively reduced the phosphorylation of JNK, ERK, p38, and NF-κB, and downregulated the expressions of the migration-promoting factors <i>MMP-2</i> and <i>MMP-9</i> in PDGF-BB-stimulated RASMCs. These findings suggest that AME protects VSMCs by regulating the phosphorylation of the MAPK/NF-κB pathway and suppressing MMP expression. Consequently, AME may help prevent or slow the progression of vascular diseases.</p>","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144078456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Randomized Placebo Controlled Clinical Study of Dill (<i>Anethum Graveolens L.</i>) in Thyroiditis and Nodular Goiter Patients.","authors":"Sabahattin Destek, İlker Demirbolat, Ayşegül Yabacı, Murat Kalemoglu, Murat Kartal, Emine Yeliz Ersoy, Vahit Onur Gul, Zulal Kayıran, Mustafa Erhan Aysan","doi":"10.1089/jmf.2024.0263","DOIUrl":"https://doi.org/10.1089/jmf.2024.0263","url":null,"abstract":"<p><p>Thyroid nodules are common and affect half of the general population by the age of 60 years. The cause is believed to be due to hypothyroidism, mutational changes, and autoimmunity leading to thyroid carcinoma. Dill, a traditional herbal remedy, has been used to treat thyroid dysfunctions such as hyperthyroidism and hypothyroidism. This study evaluates the effects of dill (<i>Anethum graveolens L.</i>) on patients with thyroiditis and nodular goiter. A study was conducted on patients with benign thyroid nodules. They were divided into two groups; placebo (=35) and dill group (<i>n</i> = 33). Dried and ground dill was put into hydroxypropyl methylcellulose capsules and patients were given three capsules per day for 90 days. Various tests were conducted at the beginning and end of the study, including thyroid stimulating hormone (TSH), free triiodothyronine (FT3), free thyroxine (FT4), anti-thyroid peroxidase (anti-TPO), anti-thyroglobulin (anti-Tg), and C-reactive protein (CRP) analysis, and thyroid nodule dimensions were measured by ultrasound. Statistical analysis was performed. After 90 days of treatment with dill extract, patients showed significant reductions in TSH, FT4, anti-TPO, and CRP levels, as well as a decrease in thyroid nodule sizes as demonstrated by ultrasonography. The dill-treated group had significantly decreased TSH (<i>P</i> = .020), FT4 (<i>P</i> = .001), anti-TPO (<i>P</i> = .004), CRP (<i>P</i> = .003) levels, and nodule sizes (<i>P</i> = .001) at the beginning and end of the study. Compared to the control group, the dill group had significantly decreased TSH (<i>P</i> = .009), fT4 (<i>P</i> < .001), anti-TPO (<i>P</i> = .001), CRP (<i>P</i> < .001) levels and nodule sizes (<i>P</i> < .001), which reached normal values. <i>A. graveolens</i> suppressed inflammation of the thyroid gland, reduced nodule size, and normalized TSH levels. Dill supplementation should be recommended for the treatment of thyroid nodules in selected patients.</p>","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143968034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}