Journal of medicinal food最新文献_第3页

Oral Supplements and Photoprotection: A Systematic Review. 口服补充剂和光防护：系统综述。

IF 1.7 3区农林科学

Journal of medicinal food Pub Date : 2025-01-13 DOI: 10.1089/jmf.2024.0023

Nicole Natarelli, Shaliz Aflatooni, Kaylee Stankiewicz, Lilia Correa-Selm, Raja K Sivamani

{"title":"Oral Supplements and Photoprotection: A Systematic Review.","authors":"Nicole Natarelli, Shaliz Aflatooni, Kaylee Stankiewicz, Lilia Correa-Selm, Raja K Sivamani","doi":"10.1089/jmf.2024.0023","DOIUrl":"https://doi.org/10.1089/jmf.2024.0023","url":null,"abstract":"Photoprotective effects of various nutritional components and supplements have been demonstrated in animal and in vitro studies. The objective of this systematic review is to assess the photoprotective effects of various dietary supplements. A systematic review of studies assessing dietary supplements on photoprotective outcomes was performed. Human studies were retrieved from PubMed, Embase, and Cochrane in February 2023. Supplement keywords included \"dietary supplements,\" \"vitamins,\" \"minerals,\" \"carotenoids,\" \"lutein,\" \"isoflavones,\" \"polyphenols,\" \"Polypodium leucotomos,\" \"heliocare,\" \"herbal medicine,\" \"probiotics,\" \"prebiotics,\" \"astaxanthin,\" \"rosmarinic acid,\" \"botanical,\" and \"herb,\" and outcome keywords included \"photoprotection,\" \"ultraviolet rays,\" UVA,\" \"UVB,\" and \"blue light.\" A total of 47 studies were included in the systematic review. Studied supplements included carotenoids, polyphenols, Polypodium leucotomos (PL), melon concentrate, vitamins, coenzyme Q, squalene, and omega-3 and omega-6 fatty acids. Some studies evaluated mixed supplementation and incorporated other active ingredients such as selenium and probiotics. The greatest evidence of photoprotection exists for polyphenols, carotenoid-based, and PL supplementation. While flavanol supplementation exhibited dose-dependency, dose-dependency could not be consistently demonstrated for polyphenol supplementation. The weakest evidence exists for photoprotective effects of isolated vitamin or coenzyme Q supplementation. Dietary supplements may promote enhanced photoprotection, although current evidence is limited by small sample size and short duration. Supplementation with photoprotective active ingredients may be especially favorable for individuals with predisposed ultraviolet sensitivity, such as those with polymorphic light eruption. Future research is necessary to determine optimal dosing and supplementation duration for intended photoprotective outcomes.","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142971281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nbeg, a Neglected Functional Fruit from Sedra (Ziziphus lotus L.): A Mini Review. 一种被忽视的功能水果——紫皮莲（Ziziphus lotus L.）：综述。

IF 1.7 3区农林科学

Journal of medicinal food Pub Date : 2025-01-08 DOI: 10.1089/jmf.2024.0193

Chemes ElHouda Messaad, Hani Belhadj

引用次数: 0

A Short-Term Murine Toxicity Study of 4'-Phosphopantetheine, a Rational Therapeutic for the Dietary Management of Inborn Errors of Coenzyme A Metabolism. 膳食管理辅酶A代谢先天缺陷的合理药物- 4'-磷酸蜂氨酸对小鼠的短期毒性研究

IF 1.7 3区农林科学

Journal of medicinal food Pub Date : 2025-01-08 DOI: 10.1089/jmf.2024.0157

Suh Young Jeong, Alison Freed, Dolly Zhen, Penelope Hogarth, Susan J Hayflick

{"title":"A Short-Term Murine Toxicity Study of 4'-Phosphopantetheine, a Rational Therapeutic for the Dietary Management of Inborn Errors of Coenzyme A Metabolism.","authors":"Suh Young Jeong, Alison Freed, Dolly Zhen, Penelope Hogarth, Susan J Hayflick","doi":"10.1089/jmf.2024.0157","DOIUrl":"https://doi.org/10.1089/jmf.2024.0157","url":null,"abstract":"Vitamin B5, or pantothenate, forms the molecular \"backbone\" of coenzyme A (CoA), which is essential for more than a hundred biochemical reactions in humans. Genetic defects that disrupt the CoA pathway cause severe degenerative disorders that may be amenable to treatment with compounds that can bypass the metabolic block. The pantothenate metabolite, 4'-phosphopantetheine (4'PPT), can serve as an alternative substrate for cellular CoA synthesis and may therefore be an essential nutrient in managing disorders where pantothenate cannot meet all metabolic requirements. 4'PPT is present in foods in low quantities, but the safety of the compound administered at higher doses than available in a normal diet has never been evaluated. In this study, we examined the effects of short-term high-dose oral 4'PPT in wild-type mice. Three doses of up to 250 mg/kg body weight were administered orally each day for 15 days. Daily body weights and cage-side general health and neurotoxicity screens were obtained. These were followed by terminal necropsy and histological analysis of major organs and tissues, including liver, kidney, heart, brain, stomach, muscle, spleen, and testis/ovary. No significant adverse effects were found in any of the analyses. We conclude that even at high doses, 4'PPT, like pantothenate, causes no observed adverse effects.","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142950267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chrysanthemum Zawadskii Var. and Platycodon Grandifloras Extract Mixture Protects Against Lipopolysaccharide-Induced Pulmonary Inflammation and Cyclophosphamide-Induced Immune Deficiency: In Vivo Evidence. 菊花和桔梗提取物混合物对脂多糖诱导的肺部炎症和环磷酰胺诱导的免疫缺陷的体内证据。

IF 1.7 3区农林科学

Journal of medicinal food Pub Date : 2025-01-06 DOI: 10.1089/jmf.2024.k.0245

Dong-Uk Jo, Yongeun Kim, Heejin Ko, Sujung Hong, Wonchul Lim, Tae-Gyu Lim

{"title":"Chrysanthemum Zawadskii Var. and Platycodon Grandifloras Extract Mixture Protects Against Lipopolysaccharide-Induced Pulmonary Inflammation and Cyclophosphamide-Induced Immune Deficiency: In Vivo Evidence.","authors":"Dong-Uk Jo, Yongeun Kim, Heejin Ko, Sujung Hong, Wonchul Lim, Tae-Gyu Lim","doi":"10.1089/jmf.2024.k.0245","DOIUrl":"https://doi.org/10.1089/jmf.2024.k.0245","url":null,"abstract":"Respiratory tract diseases (RTDs) cause airflow limitations and impaired respiratory function, primarily due to pulmonary inflammation and immune dysfunction. Chrysanthemum zawadskii var. latilobum Kitamur and Platycodon grandifloras (CP) are traditional herbs known for their anti-inflammatory and immune-enhancing properties. This study investigates the anti-inflammatory and immune-enhancing effects of a combined extract of CP in vivo. CP was prepared by mixing equal volumes of Chrysanthemum zawadskii extract (CE) and Platycodon grandifloras extract (PE) at the same concentration. The anti-inflammatory effects of CP were evaluated using a lipopolysaccharide (LPS)-induced inflammation model in BALB/c mice. The immune-enhancing effects were assessed using a cyclophosphamide (CYP)-induced immunosuppression model. Protein and mRNA expressions of inflammatory and immune markers were analyzed through Western blotting and quantitative real-time PCR. CP significantly reduced LPS-induced pulmonary inflammation by decreasing interleukin (IL)-1β and cyclooxygenase-2 expression in lung tissues. In the CYP-induced model, CP treatment restored spleen and thymus weights, reversed reductions in immune cell counts, and increased TNF-α and IL-2 mRNA expression in the spleen. In conclusion, CP inhibits pulmonary inflammation by suppressing inflammatory mediators and enhances immune function by increasing immune-related indicators. This suggests that CP may have potential therapeutic applications for treating respiratory inflammation and related diseases.","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142931991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of Hair Growth Promoting Activity of Standardized Soybean Extract on Testosterone-Induced Alopecia. 标准化大豆提取物对睾酮性脱发促发活性的评价。

IF 1.7 3区农林科学

Journal of medicinal food Pub Date : 2025-01-01 Epub Date: 2025-01-03 DOI: 10.1089/jmf.2023.0117

Alaa Youssef, Dalia A Al-Mahdy, Rabab H Sayed, Mouchira A Choucry, Hesham El-Askary

{"title":"Evaluation of Hair Growth Promoting Activity of Standardized Soybean Extract on Testosterone-Induced Alopecia.","authors":"Alaa Youssef, Dalia A Al-Mahdy, Rabab H Sayed, Mouchira A Choucry, Hesham El-Askary","doi":"10.1089/jmf.2023.0117","DOIUrl":"10.1089/jmf.2023.0117","url":null,"abstract":"Millions of men and women suffer from alopecia, especially androgenic alopecia (AGA), which is considered the most common form of hair loss. The available treatments for hair loss include multiple approaches, with the most popular being synthetic drugs including minoxidil and finasteride, in addition to natural products. However, synthetic drugs have shown many undesirable side effects, on the contrary, the specifications of the commonly used natural drugs have not been reported in most of the previous studies, despite the high market preference for them. One of these natural drugs is soybean (Glycine max), an economically important bean that has been reported in several studies to effectively prevent hair loss in humans and is widely used in many products treating alopecia. However, no reports were traced on the specification and standardization of the used soybean extract, which may lead to unreproducible results. Thus, in this study, we investigated the effects of different concentrations; 1%, 3%, and 5% (v/v) of a specified soybean extract (SSE) in coconut oil, using a testosterone-induced model of alopecia in adult male Wistar rats in comparison with a 2% finasteride solution. Visual and microscopical evaluations of follicular diameter, length, and density were performed. The data showed that 5% of SSE exhibited the highest activity with results comparable to standard 2% finasteride for hair diameter, length, and density, which could be attributed to the extract's isoflavone content. Genistin and diadzin isoflavones were isolated from the ethyl acetate fraction of the SSE. The total extract was standardized using high-performance liquid chromatography using genistin as a marker and showed a content of 6.2 µg/mL. Accordingly, the formulated 3% and 5% SSEs (containing 0.186 and 0.31 µg/mL of genistin, respectively) could be considered as a promising natural treatment for AGA.","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":"75-86"},"PeriodicalIF":1.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142921842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficacy and Safety of Vuong Hoat Natural Health Supplement in Managing Low Back Pain: A Randomized Clinical Trial. Vuong Hoat 天然保健品治疗腰背痛的有效性和安全性：随机临床试验。

IF 1.7 3区农林科学

Journal of medicinal food Pub Date : 2025-01-01 Epub Date: 2024-11-20 DOI: 10.1089/jmf.2023.0284

Phuong T Pham, Quan T Hoang, Lam V Trinh, Anh K Nguyen, Bo Han, Ba X Hoang

{"title":"Efficacy and Safety of Vuong Hoat Natural Health Supplement in Managing Low Back Pain: A Randomized Clinical Trial.","authors":"Phuong T Pham, Quan T Hoang, Lam V Trinh, Anh K Nguyen, Bo Han, Ba X Hoang","doi":"10.1089/jmf.2023.0284","DOIUrl":"10.1089/jmf.2023.0284","url":null,"abstract":"This clinical study aimed to assess the effectiveness and safety of Vuong Hoat (VH) natural health supplement for reducing the negative impact of low back pain, improving the quality of life, and enhancing functional activities in patients with lumbar degenerative disc disease (LDD). The open-label, randomized, controlled clinical trial involved 60 patients suffering from low back pain caused by LDD. The participants were randomly assigned to either a study group (SG) comprising 30 subjects or a control group (CG) comprising 30 subjects. Patients in the CG received treatment with electro-acupuncture, while those in the SG were administered VH in conjunction with the same electro-acupuncture protocol for 28 days. The clinical progression and tolerability of both groups were compared based on seven objective measurements: visual analog scale index, Schober test, fingertip-to-floor distance, spinal flexion, spinal extension, spinal tilt, and spinal rotation. After 14 days of treatment, the SG showed a significant improvement in overall outcomes compared to the CG. Specifically, 43.3% of SG patients achieved very good results, 53.3% had good results, and 3.4% had moderate results, whereas corresponding figures for the CG were 6.7%, 76.7%, and 16.6%, respectively (P < .05). After 28 days of treatment, both groups demonstrated a shift toward very good results, with the SG continuing to show better outcomes than the CG (P < .05). In the SG, the very good results increased to 76.7%, good results decreased to 20%, and moderate results were 3.3%. On the other hand, the CG had 46.7% very good results, 43.3% good results, and 10% moderate results. Notably, no side effects were reported from the VH treatments during the study. The findings of this study indicate that VH health supplement is a safe and effective approach for managing low back pain and limited spinal movement in patients with LDD.","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":"87-95"},"PeriodicalIF":1.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142676003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Metabolites Generated from Foods Through Lactic Fermentation and Their Benefits on the Intestinal Microbiota and Health. 食物经乳酸发酵产生的代谢物及其对肠道微生物群和健康的益处

IF 1.7 3区农林科学

Journal of medicinal food Pub Date : 2025-01-01 Epub Date: 2024-10-30 DOI: 10.1089/jmf.2023.0218

Daniela Guzmán-Escalera, Elia Herminia Valdés-Miramontes, Laura E Iñiguez-Muñoz, Zyanya Reyes-Castillo, Ana C Espinoza-Gallardo

{"title":"Metabolites Generated from Foods Through Lactic Fermentation and Their Benefits on the Intestinal Microbiota and Health.","authors":"Daniela Guzmán-Escalera, Elia Herminia Valdés-Miramontes, Laura E Iñiguez-Muñoz, Zyanya Reyes-Castillo, Ana C Espinoza-Gallardo","doi":"10.1089/jmf.2023.0218","DOIUrl":"10.1089/jmf.2023.0218","url":null,"abstract":"Metabolites generated in foods with lactic fermentation have been subject of research in recent years due to different beneficial effects attributed to them on the microbiota and health in general, including their properties as antihypertensives, antioxidants, anti-inflammatory, immunomodulatory, and antimicrobial, among others. The present review aims to systematically analyze the results of original research that evaluates effects on the microbiota and health in general, mediated by metabolites generated from the lactic fermentation of foods. The review was carried out in the PubMed database, three studies in humans, four in vivo studies in murine models, four in vitro studies, and the rest focused on the quantification of biofunctional qualities in fermented foods were analyzed. The results of the studies compiled in this systematic review reveal the potential of different food matrices and microorganisms to generate metabolites through lactic fermentation with important properties and effects on the intestinal microbiota and other health benefits. Among these benefits is the increase in short chain fatty acids to which anti-inflammatory properties are associated, as well as bioactive peptides with antihypertensive, antithrombotic, antioxidant, anti-inflammatory, and antimicrobial properties.","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":"1-11"},"PeriodicalIF":1.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142545978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Natural Honey Proteins Prevent Diet-Induced Obesity and Metabolic Disorders in Rats. 天然蜂蜜蛋白质可预防饮食引起的大鼠肥胖和代谢紊乱。

IF 1.7 3区农林科学

Journal of medicinal food Pub Date : 2025-01-01 Epub Date: 2024-10-31 DOI: 10.1089/jmf.2024.k.0093

Atia Gohar, Richard L Atkinson, Darakhshan J Haleem, Khaled Fahmi Fawy, Muhammad Shakeel

{"title":"Natural Honey Proteins Prevent Diet-Induced Obesity and Metabolic Disorders in Rats.","authors":"Atia Gohar, Richard L Atkinson, Darakhshan J Haleem, Khaled Fahmi Fawy, Muhammad Shakeel","doi":"10.1089/jmf.2024.k.0093","DOIUrl":"10.1089/jmf.2024.k.0093","url":null,"abstract":"Previous studies have shown that oral whole honey reduces weight gain in rats on a normal diet (ND) or high-fat diet (HFD) and suppresses inflammation by modulating immunological cytokines in human neutrophils and macrophages. We hypothesize that the honey proteins (HP) are responsible for the reduced weight gain in rats on ND and HFD and that HP would alleviate obesity parameters. To test this, proteins were isolated from acacia honey through the salting-out method. Wistar rats (N = 24) were randomized to get ND or HFD for 4 weeks, then further randomized to four groups and treated with HP or saline for another 4 weeks. Energy intake (EI), body weight gain, EI per gram body weight gain, serum glucose, and lipids were measured. Expression of adipose tissue genes fatty acid binding protein (FABP), lipase C (LIPC), and apolipoprotein A-1 (APOA1) was evaluated through the quantitative polymerase chain reaction. HFD increased the body weight versus ND in weeks 1-4. HP for the next 4 weeks reduced weight gain in ND-HP and HFD-HP groups versus saline controls (P < .01). EI was not significantly different among groups. However, EI per gram body weight gain among groups was markedly different (P < .01), demonstrating reduced weight gain efficiency by HP (P < .01). HP reduced glucose in ND but not in HFD groups. Triglycerides were lower in both HP groups. The expressions of FABP, LIPC, and APOA1 genes were significantly increased (P < .05) in HP-treated HFD rats. Collectively, weight gain efficiency was remarkably reduced without altering EI in rats following the HP treatment, suggesting HP increased metabolic rate or substrate partitioning. Studies of HP are suggested in humans.","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":"68-74"},"PeriodicalIF":1.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142545979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Cervus Elaphus and Eucommia Ulmoides Extract Blend Attenuates Muscle Atrophy by Regulating Protein Metabolism and Antioxidant Activity. 马鹿杜仲提取物通过调节蛋白质代谢和抗氧化活性减轻肌肉萎缩。

IF 1.7 3区农林科学

Journal of medicinal food Pub Date : 2025-01-01 Epub Date: 2024-12-30 DOI: 10.1089/jmf.2024.k.0220

Jeongjin Park, Gi-Bang Koo, Han Ol Kwon, Jong Han Kim, Woojin Jun

{"title":"A Cervus Elaphus and Eucommia Ulmoides Extract Blend Attenuates Muscle Atrophy by Regulating Protein Metabolism and Antioxidant Activity.","authors":"Jeongjin Park, Gi-Bang Koo, Han Ol Kwon, Jong Han Kim, Woojin Jun","doi":"10.1089/jmf.2024.k.0220","DOIUrl":"10.1089/jmf.2024.k.0220","url":null,"abstract":"Here, we investigated whether a mixture of Cervus elaphus and Eucommia ulmoides (1:3, KGC01CE) could suppress muscle atrophy in H2O2-induced C2C12 cells and dexamethasone-injected mice. Our results revealed that KGC01CE effectively safeguarded against H2O2-induced muscle atrophy in C2C12 cells compared with the same mixture at other ratios. We demonstrated that dexamethasone elicited oxidative stress in muscle tissue and decreased the grip strength and cross-sectional areas of muscle fibers; however, oral administration of KGC01CE (1:3) suppressed these dexamethasone-induced changes. Furthermore, oral KGC01CE (1:3) administration suppressed the expression of protein degradation-associated factors, myostatin, muscle RING finger 1, and atrogin-1 in muscle tissue from dexamethasone-injected mice. Oral KGC01CE administration stimulated protein synthesis by stimulating the PI3K/Akt/mTOR pathway in muscle tissue from dexamethasone-injected mice. These findings indicate that KGC01CE can suppress dexamethasone injection-induced muscle atrophy by inhibiting protein degradation and promoting muscle hypertrophy. Therefore, KGC01CE supplementation helps prevent muscle atrophy in mice and may be beneficial against various components of muscle atrophy.","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":"58-67"},"PeriodicalIF":1.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142895542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Schisandrol A Alleviates Allergic Asthma in Mice via Regulating the NF-κB/IκBα and Nrf2/HO-1 Signaling Pathways. 五味子醇 A 通过调节 NF-κB/IκBα 和 Nrf2/HO-1 信号通路缓解小鼠过敏性哮喘

IF 1.7 3区农林科学

Journal of medicinal food Pub Date : 2025-01-01 Epub Date: 2024-09-24 DOI: 10.1089/jmf.2024.k.0117

Yang Dong, Yi-Zhuo Zou, Ting Li, Jing-Hui Sun, He Li, Wen-Yue Zhuang, Yan Song, Chun-Mei Wang

{"title":"Schisandrol A Alleviates Allergic Asthma in Mice via Regulating the NF-κB/IκBα and Nrf2/HO-1 Signaling Pathways.","authors":"Yang Dong, Yi-Zhuo Zou, Ting Li, Jing-Hui Sun, He Li, Wen-Yue Zhuang, Yan Song, Chun-Mei Wang","doi":"10.1089/jmf.2024.k.0117","DOIUrl":"10.1089/jmf.2024.k.0117","url":null,"abstract":"Schisandra chinensis (Turcz) Baill (S. chinensis) is the key traditional Chinese medicine for the treatment of asthma used by ancient and modern medical practitioners. However, the material basis and the main mechanism of its antiasthmatic effect remain unclear. Our preliminary results showed that schisandrol A (SCA), a representative monomer of Schisandra lignans, had the best relaxation effect on tracheal rings in isolated rats. In this research, a mouse asthma model was prepared by combining ovalbumin (OVA) with Al (OH)3 for exploring the antiasthmatic action and the underlying mechanism of SCA. The study results demonstrated that SCA improved the behavior of mice with asthma and pathological changes in their lung tissues and airways, decreased serum immunoglobulin E (IgE) and OVA-IgE levels, interleukin-4 (IL-4), IL-5, IL-13, and eotaxin contents, and leukocytes number in bronchoalveolar lavage fluid. SCA downregulated the gene expressions of keratinocyte-derived protein chemokines and ILs and reduced the expressions of phosphorylated IκB kinase α (p-IKKα) and p-nuclear factor kappa-B (NF-κB) proteins in lung tissues. In addition, it was found that SCA could significantly increase T-superoxide dismutase and catalase activities, decrease malondialdehyde content, and elevate p-IκBα, NF-E2-related-factor 2 (Nrf2), and heme oxygenase-1 (HO-1) protein expressions. In summary, SCA treatment resulted in a significant improvement in the allergic bronchial asthma in mice, and its mechanisms may involve the regulation of the NF-κB/IκBα pathway to reduce inflammatory response and the Nrf2/HO-1 pathway to improve the body's antioxidant capacity. These results suggest that SCA is a key component of S. chinensis in exerting antiasthmatic effects.","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":"28-37"},"PeriodicalIF":1.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142307951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0