Journal of medicinal food最新文献

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Hydrolyzed Keratin Peptide Enhances Hair Condition and Promotes Hair Regeneration. 水解角蛋白肽改善头发状况,促进头发再生。
IF 1.8 3区 农林科学
Journal of medicinal food Pub Date : 2026-09-01 Epub Date: 2026-05-26 DOI: 10.1177/1096620X261453142
San Kim, Jun Young Kim, Ji Won Leem, Hyeon Jeong Jo, Ji Won Leem, Ha Yeong Kang, Eun-Hye Han, Bong-Gyeong Lee, Hai-Hua Jiang, Eunmiri Roh, Sung Keun Jung
{"title":"Hydrolyzed Keratin Peptide Enhances Hair Condition and Promotes Hair Regeneration.","authors":"San Kim, Jun Young Kim, Ji Won Leem, Hyeon Jeong Jo, Ji Won Leem, Ha Yeong Kang, Eun-Hye Han, Bong-Gyeong Lee, Hai-Hua Jiang, Eunmiri Roh, Sung Keun Jung","doi":"10.1177/1096620X261453142","DOIUrl":"10.1177/1096620X261453142","url":null,"abstract":"<p><p>Growing interest in hair health has increased the demand for safe and effective hair growth agents. Keratin, a structural protein abundant in hair, skin, and nails, is essential for maintaining hair integrity and resilience. This study evaluated the effects of orally administered hydrolyzed keratin peptide on hair growth in male and female C57BL/6 mice and its cellular impact on human follicle dermal papilla cells (HFDPCs) and HaCaT keratinocytes. Oral administration of hydrolyzed keratin peptide promoted the telogen-to-anagen transition and increased expression of proliferation markers (<i>β-catenin, cyclin D1</i>, and proliferating cell nuclear antigen [<i>PCNA</i>]) in both sexes, while upregulating growth factors and antioxidant enzymes in male mice. <i>In vitro</i>, hydrolyzed keratin peptide enhanced HFDPC proliferation by activating <i>β-catenin</i> and improving cellular antioxidant capacity in both HaCaT keratinocytes and HFDPCs. These findings suggest that hydrolyzed keratin peptides are a promising functional food ingredient for promoting hair health through both proliferative and antioxidant mechanisms.</p>","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":"555-566"},"PeriodicalIF":1.8,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148031807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Retraction: Therapeutic Effect of Acer tegmentosum Maxim Twig Extract in Bile Duct Ligation-Induced Acute Cholestasis in Mice. 缩回:槭叶提取物对胆管结扎致小鼠急性胆汁淤积症的治疗作用。
IF 1.8 3区 农林科学
Journal of medicinal food Pub Date : 2026-09-01 Epub Date: 2026-04-24 DOI: 10.1177/1096620X261443792
{"title":"<i>Retraction:</i> Therapeutic Effect of <i>Acer tegmentosum</i> Maxim Twig Extract in Bile Duct Ligation-Induced Acute Cholestasis in Mice.","authors":"","doi":"10.1177/1096620X261443792","DOIUrl":"10.1177/1096620X261443792","url":null,"abstract":"","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":"576"},"PeriodicalIF":1.8,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147774218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Antidiarrheal Activity of Fermented Soybean Powder by Bacillus subtilis DKU_09 Strain in Mice with Castor Oil-Induced Diarrhea. 枯草芽孢杆菌DKU_09菌株发酵大豆粉对蓖麻油致腹泻小鼠的止泻作用
IF 1.8 3区 农林科学
Journal of medicinal food Pub Date : 2026-09-01 Epub Date: 2026-06-19 DOI: 10.1177/1096620X261462218
Su Kang Kim, Min Kyoung Kim, Chung-Hun Oh, Ju Yeon Ban
{"title":"Antidiarrheal Activity of Fermented Soybean Powder by <i>Bacillus subtilis</i> DKU_09 Strain in Mice with Castor Oil-Induced Diarrhea.","authors":"Su Kang Kim, Min Kyoung Kim, Chung-Hun Oh, Ju Yeon Ban","doi":"10.1177/1096620X261462218","DOIUrl":"10.1177/1096620X261462218","url":null,"abstract":"<p><p>Diarrhea is characterized by excessive intestinal secretion and motility, often linked to inflammatory activation. Although synthetic antidiarrheal drugs are effective, their prolonged use can cause side effects, underscoring the need for safe, natural alternatives.This study investigated the antidiarrheal and anti-inflammatory activities of <i>Bacillus subtilis</i> DKU_09-fermented soybean (FS) powder in a mouse model of castor oil-induced diarrhea.Male ICR mice were orally administered FS (100, 200, or 300 mg/kg) for 7 days before the induction of diarrhea with castor oil. Diarrheal onset, frequency, fecal water content, and gastrointestinal (GI) transit were recorded. Inflammatory mediators in the small intestine were analyzed using real-time polymerase chain reaction and Western blotting, while serum immunoglobulin A (IgA) and immunoglobulin G (IgG) were measured by enzyme-linked immunosorbent assay.Pretreatment with FS significantly delayed the onset of diarrhea (FS200: 132.0 ± 9.8 min vs. castor oil-treated control [DC]: 76.9 ± 5.6 min, <i>P</i> < .05) and reduced diarrheal frequency (FS200: 32.9 ± 5.4% vs. DC: 51.9 ± 6.1%, <i>P</i> < .05). FS normalized the accelerated GI transit and markedly suppressed intestinal inflammation. The expression of <i>Il-1β</i>, <i>Cox-2</i>, <i>mPGES-1</i>, and <i>NF-κB</i> (<i>p65</i>) mRNA was significantly decreased by FS, accompanied by inhibition of mitogen-activated protein kinase (MAPK) phosphorylation (ERK, JNK, and p38). Serum IgG and IgA levels were unaffected, indicating that the effects were localized to intestinal tissue.Soybeans fermented by <i>B. subtilis</i> DKU_09 exert potent antidiarrheal effects through suppression of the NF-κB/Cox-2/PGE<sub>2</sub> and MAPK signaling pathways, thereby reducing intestinal inflammation and motility. These findings suggest that the FS used in the present study may serve as a safe and natural functional food for the management of acute diarrhea.</p>","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":"567-575"},"PeriodicalIF":1.8,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148277673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Corrigendum to: "Black Raspberry and Phlomis Umbrosa Turcz. Extract Mixture (BLB301) Alleviates Dexamethasone-Induced Muscle Atrophy by Modulating Oxidative Stress and Protein Turnover Pathways". 更正:“黑覆盆子和凤梨。”提取物混合物(BLB301)通过调节氧化应激和蛋白质转换途径减轻地塞米松诱导的肌肉萎缩。
IF 1.8 3区 农林科学
Journal of medicinal food Pub Date : 2026-09-01 Epub Date: 2026-07-25 DOI: 10.1177/1096620X261470290
{"title":"<i>Corrigendum to:</i> \"Black Raspberry and Phlomis Umbrosa Turcz. Extract Mixture (BLB301) Alleviates Dexamethasone-Induced Muscle Atrophy by Modulating Oxidative Stress and Protein Turnover Pathways\".","authors":"","doi":"10.1177/1096620X261470290","DOIUrl":"10.1177/1096620X261470290","url":null,"abstract":"","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":"577"},"PeriodicalIF":1.8,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148592297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Toxicological Characterization of Polyporus umbellatus Extract: Genotoxicity and 2-Week Repeated-Dose Toxicity Study. 伞形蓼提取物的毒理学特征:遗传毒性和2周重复剂量毒性研究。
IF 1.8 3区 农林科学
Journal of medicinal food Pub Date : 2026-08-31 DOI: 10.1177/1096620X261481643
Yeon-Woo Kim, Se-Myo Park, Mi-Sun Choi, Heeyoung Yang, Jung-Hwa Oh, Seokjoo Yoon, Hyoung-Yun Han, Jung-Heun Ha
{"title":"Toxicological Characterization of <i>Polyporus umbellatus</i> Extract: Genotoxicity and 2-Week Repeated-Dose Toxicity Study.","authors":"Yeon-Woo Kim, Se-Myo Park, Mi-Sun Choi, Heeyoung Yang, Jung-Hwa Oh, Seokjoo Yoon, Hyoung-Yun Han, Jung-Heun Ha","doi":"10.1177/1096620X261481643","DOIUrl":"https://doi.org/10.1177/1096620X261481643","url":null,"abstract":"<p><p><i>Polyporus umbellatus</i> is a traditional medicinal fungus with potential application as a food-related bioactive; however, toxicological data for concentrated extracts remain limited. This study evaluated aqueous <i>P. umbellatus</i> extract using three complementary genotoxicity assays and a 2-week repeated-dose toxicity study. Genotoxicity was assessed using an <i>in vitro</i> chromosomal aberration assay in Chinese hamster lung cells, a bacterial reverse mutation assay, and an <i>in vivo</i> bone marrow micronucleus assay. The repeated-dose toxicity study was performed in F344 rats administered 500, 1000, or 2000 mg/kg/day <i>P. umbellatus</i> extract by oral gavage for 2 weeks. <i>P. umbellatus</i> extract significantly increased structural chromosomal aberrations <i>in vitro</i> under short-term treatment with metabolic activation, and under short-term and continuous-treatment conditions without metabolic activation. In contrast, the extract did not increase revertant colonies of <i>Salmonella typhimurium</i> or <i>Escherichia coli</i> tester strains, and oral administration did not increase micronucleated polychromatic erythrocytes in male or female ICR mice. Repeated oral administration for 2 weeks caused no mortality, treatment-related clinical signs, body weight loss, gross lesions, or consistent hematological or serum biochemical toxicity patterns. Isolated changes in male kidney weight, female salivary gland weight, and male creatine kinase activity were not accompanied by concordant findings and were therefore not interpreted as definitive adverse effects. Overall, the findings indicate an <i>in vitro</i> clastogenic response without evidence of bacterial mutagenicity, bone marrow micronucleus induction, or overt repeated-dose oral toxicity under the investigated experimental conditions, paving the way for long-term studies to complete the toxicological characterization of <i>P. umbellatus</i>.</p>","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":"1096620X261481643"},"PeriodicalIF":1.8,"publicationDate":"2026-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148865522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Effect of a Supplement Containing Bergamot and Plant Sterols with or Without a Diet on Dyslipidemia: A Randomized Controlled Trial. 含佛手柑和植物甾醇补充剂对血脂异常的影响:一项随机对照试验。
IF 1.8 3区 农林科学
Journal of medicinal food Pub Date : 2026-08-31 DOI: 10.1177/1096620X261484568
Aysu Nur Yündem, Hande Seven Avuk
{"title":"The Effect of a Supplement Containing Bergamot and Plant Sterols with or Without a Diet on Dyslipidemia: A Randomized Controlled Trial.","authors":"Aysu Nur Yündem, Hande Seven Avuk","doi":"10.1177/1096620X261484568","DOIUrl":"https://doi.org/10.1177/1096620X261484568","url":null,"abstract":"<p><p>Dyslipidemia is a significant risk factor for cardiovascular disease. This study evaluated the efficacy of a cholesterol-lowering diet, a supplement containing bergamot and plant sterols, and their combination in managing dyslipidemia. In this 12-week randomized controlled trial, 61 adults with dyslipidemia were assigned to one of three groups: diet-only (Group D, <i>n</i> = 19), supplement-only (Group B, <i>n</i> = 21; 150 mg bergamot flavonoids + 800 mg plant sterols/day), or mixed (Group M, <i>n</i> = 21; Diet + Supplement). Efficacy was assessed via changes in biochemical and anthropometric parameters. The primary finding was the superior efficacy of the mixed group (Group M), which demonstrated significantly greater reductions in total cholesterol (-53.9 mg/dL; -19.8%), low-density lipoprotein cholesterol (LDL-C) (-42.6 mg/dL; -23.3%), and triglycerides (TGs) (-57.2 mg/dL; -29.7%) compared to both diet-only and supplement-only groups (<i>P</i> < .05). While all three groups showed improved total and LDL-C, TG levels decreased significantly only in the supplement-receiving groups (Group B and Group M). Conversely, dietary intervention primarily drove significant improvements in body weight (Group D: -4.2 kg; Group M: -3.4 kg), body mass index (-1.5 and -1.2 kg/m<sup>2</sup>, respectively), and fat mass (-3.5 and -2.9 kg, respectively). High-density lipoprotein cholesterol and liver enzymes (alanine aminotransferase, aspartate aminotransferase) remained unchanged across all groups. Combining a cholesterol-lowering diet with a bergamot and plant sterol supplement offers a synergistic and superior strategy for improving the lipid profile in individuals with dyslipidemia, while the dietary component remains essential for improving body composition.</p>","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":"1096620X261484568"},"PeriodicalIF":1.8,"publicationDate":"2026-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148865519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lacticaseibacillus paracasei HP7 Attenuates Helicobacter pylori Activity and Improves Upper Gastrointestinal Symptoms: A Double-Blind, Randomized, Placebo-Controlled, Clinical Trial. 副干酪样乳杆菌HP7降低幽门螺杆菌活性并改善上消化道症状:一项双盲、随机、安慰剂对照的临床试验
IF 1.8 3区 农林科学
Journal of medicinal food Pub Date : 2026-08-31 DOI: 10.1177/1096620X261481599
Jae-Ho Lee, Ju-Yeon Kim, Eun-Ji Kim, Il-Dong Choi, Jae-Jung Shim, Seong-Soo Hong, Jong-Cheon Joo, Jae-Hwan Lee
{"title":"<i>Lacticaseibacillus paracasei</i> HP7 Attenuates <i>Helicobacter pylori</i> Activity and Improves Upper Gastrointestinal Symptoms: A Double-Blind, Randomized, Placebo-Controlled, Clinical Trial.","authors":"Jae-Ho Lee, Ju-Yeon Kim, Eun-Ji Kim, Il-Dong Choi, Jae-Jung Shim, Seong-Soo Hong, Jong-Cheon Joo, Jae-Hwan Lee","doi":"10.1177/1096620X261481599","DOIUrl":"https://doi.org/10.1177/1096620X261481599","url":null,"abstract":"<p><p><i>Helicobacter pylori</i> remains a major cause of chronic gastritis and dyspeptic symptoms, and the effectiveness of standard eradication therapy continues to decline with increasing antibiotic resistance. <i>Lacticaseibacillus paracasei</i> HP7 has shown inhibitory and anti-inflammatory effects on <i>H. pylori</i> in preclinical studies. This study investigated whether 8-week oral HP7 supplementation could improve <i>H. pylori</i>-related outcomes in adults with confirmed infection. Seventy-eight adults with positive <sup>13</sup>C-urea breath test (<sup>13</sup>C-UBT) results and gastric discomfort were randomized to receive low-dose HP7 (HP7-L, 1.5 × 10<sup>9</sup> CFU/day), high-dose HP7 (HP7-H, 5.0 × 10<sup>9</sup> CFU/day), or placebo for 8 weeks. Outcomes included changes in <sup>13</sup>C-UBT values, upper gastrointestinal (GI) symptoms assessed by Korean Gastrointestinal Symptom Rating Scale, pepsinogen I/II ratio, serum tumor necrosis factor-α, and quality-of-life indices. HP7-H significantly reduced <sup>13</sup>C-UBT values compared with placebo. HP7 supplementation was also associated with improvements in gastric mucosal biomarkers and modest changes in selected upper GI symptom and quality-of-life domains. Overall microbial diversity was not significantly altered, although the abundance of <i>L. paracasei</i> increased following supplementation. No treatment-related serious adverse events were observed, and all laboratory findings remained within clinical reference ranges. Complete eradication of <i>H. pylori</i> was not achieved in most participants. These findings support the clinical potential of HP7 supplementation to attenuate <i>H. pylori</i>-related activity and improve gastric biomarkers, with modest benefits in selected dyspeptic symptom domains. HP7 may be a safe and effective functional food option for <i>H. pylori</i> management when antibiotics are contraindicated or ineffective. Further studies are warranted to confirm long-term efficacy and durability of these effects.</p>","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":"1096620X261481599"},"PeriodicalIF":1.8,"publicationDate":"2026-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148865456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
DX3004-Derived GABA Fermentate Ameliorates Stress-Induced Auditory Dysfunction-Associated Phenotypes Through Modulation of Auditory-Related Molecular Responses and Oxidative Stress in Drosophila melanogaster. dx3004衍生的GABA发酵物通过调节黑胃果蝇听觉相关分子反应和氧化应激改善应激诱导的听觉功能障碍相关表型
IF 1.8 3区 农林科学
Journal of medicinal food Pub Date : 2026-08-28 DOI: 10.1177/1096620X261481626
Do-Young Park, Dowon Park, Bonggyu Min, Suwon Lee, Kyuchan Kwon, Chongyoon Lim
{"title":"DX3004-Derived GABA Fermentate Ameliorates Stress-Induced Auditory Dysfunction-Associated Phenotypes Through Modulation of Auditory-Related Molecular Responses and Oxidative Stress in <i>Drosophila melanogaster</i>.","authors":"Do-Young Park, Dowon Park, Bonggyu Min, Suwon Lee, Kyuchan Kwon, Chongyoon Lim","doi":"10.1177/1096620X261481626","DOIUrl":"https://doi.org/10.1177/1096620X261481626","url":null,"abstract":"<p><p>Environmental stress is increasingly recognized as a contributor to auditory dysfunction through disruption of mechanotransduction-related processes and induction of oxidative stress. This study evaluated the protective effects of a <i>γ</i>-aminobutyric acid (GABA)-enriched fermentate (DX3004-GABA), derived from <i>Levilactobacillus brevis</i> DX3004, using a <i>Drosophila melanogaster</i> model of cold stress-induced auditory dysfunction. Auditory-associated phenotypes were assessed by courtship song-induced chaining behavior, and expression of mechanotransduction-related (<i>nan</i>, <i>nompB</i>), ciliary integrity-associated (<i>btv</i>, <i>rempA</i>, <i>ninaC</i>, <i>tilB</i>), and gene expressions related to antioxidant defense (<i>cncC</i>, <i>cat</i>, <i>sod</i>) was analyzed by quantitative real-time polymerase chain reaction. Cold stress markedly impaired chaining behavior, downregulated auditory-related gene expression, and increased both dihydroethidium-reactive and 2',7'-dichlorofluorescein (DCF)-reactive reactive oxygen species (ROS) levels in fly head samples. Supplementation with DX3004-GABA significantly improved auditory dysfunction-associated phenotypes, restored auditory-related gene expression, and reduced ROS accumulation more effectively than purified GABA. In addition, DX3004-GABA enhanced antioxidant defense-associated gene expression, suggesting improved redox regulation. Collectively, these findings indicate that a GABA-enriched fermentate ameliorates cold stress-induced auditory dysfunction-associated phenotypes through coordinated modulation of auditory-related molecular responses and oxidative stress-associated pathways. The enhanced efficacy of DX3004-GABA compared with purified GABA raises the possibility that additional fermentation-derived metabolites contribute to the observed biological activity, highlighting the potential of postbiotic fermentates as functional ingredients for stress-associated conditions.</p>","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":"1096620X261481626"},"PeriodicalIF":1.8,"publicationDate":"2026-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148840339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cudrania tricuspidata Leaf-Derived Polysaccharides Attenuate Cisplatin-Induced Cytotoxicity in HEK 293T Cells via the Nrf2/HO-1 Pathway. 三毛藤叶源多糖通过Nrf2/HO-1途径减弱顺铂诱导的HEK 293T细胞毒性
IF 1.8 3区 农林科学
Journal of medicinal food Pub Date : 2026-08-28 DOI: 10.1177/1096620X261481636
Hea-Ju Cho, Eui-Hong Byun
{"title":"<i>Cudrania tricuspidata</i> Leaf-Derived Polysaccharides Attenuate Cisplatin-Induced Cytotoxicity in HEK 293T Cells <i>via</i> the Nrf2/HO-1 Pathway.","authors":"Hea-Ju Cho, Eui-Hong Byun","doi":"10.1177/1096620X261481636","DOIUrl":"https://doi.org/10.1177/1096620X261481636","url":null,"abstract":"<p><p>Prolonged administration of cisplatin, a widely used chemotherapeutic agent, induces nephrotoxicity. Identifying natural compounds that attenuate cisplatin's adverse effects on renal tissues would be of clinical value. Thus, the present study aimed to evaluate the cytoprotective effects of <i>Cudrania tricuspidata</i> leaf-derived polysaccharides (CTP) in human embryonic kidney (HEK) 293T cells to explore their potential as a chemotherapeutic adjuvant. In the cell viability assay, CTP alone showed no inherent cytotoxic effects, whereas co-treatment with cisplatin led to a significant improvement in cell viability. These observations were corroborated by Annexin V/propidium iodide staining, which demonstrated that CTP effectively attenuated cisplatin-induced cell damage in HEK 293T cells. CTP also increased the total antioxidant capacity in the 2,2-diphenyl-1-picrylhydrazyl, 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid), and ferric reducing antioxidant power assays in a dose-dependent manner while elevating the activities of intracellular antioxidant enzymes, including catalase and superoxide dismutase, which correlated with the expression of nuclear factor erythroid 2-related factor 2 and heme oxygenase-1. Moreover, CTP reduced malondialdehyde levels, indicating that it protected against oxidative-stress-induced membrane damage. Mechanistically, CTP mitigated cisplatin-induced apoptosis by upregulating B cell lymphoma 2 (Bcl-2) expression while suppressing the expression of Bcl-2-associated X protein, cleaved caspase-3, and caspase-9. Collectively, the findings demonstrate that pretreatment with CTP protected HEK 293T cells from cisplatin-induced damage, highlighting its potential as a functional food ingredient.</p>","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":"1096620X261481636"},"PeriodicalIF":1.8,"publicationDate":"2026-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148840295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Attenuation of Fasting and Postprandial Glucose Exposure by Standardized Salacia reticulata Extract in Adults with Prediabetes: A Randomized, Double-Blind, Placebo-Controlled Trial. 标准化网槐提取物降低成人糖尿病前期空腹和餐后葡萄糖暴露:一项随机、双盲、安慰剂对照试验。
IF 1.8 3区 农林科学
Journal of medicinal food Pub Date : 2026-08-28 DOI: 10.1177/1096620X261479626
Hyang-Im Baek, Yuri Gwon, Soo Jung Park
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