Journal of medicinal food最新文献

{"title":"In Silico and In Vivo Biological Evaluation of Extracts from Tunisian Desert Truffles (<i>Tirmania nivea</i> and <i>Terfezia boudieri</i>) on Scopolamine-Induced Memory Impairment in Mice.","authors":"Mohamed Ali Smach, Rihab Hammami, Amira Zarrouk, Jawhar Hafsa, Bassem Charfeddine, Khalifa Limem, Ayda Khadhri","doi":"10.1089/jmf.2023.0178","DOIUrl":"https://doi.org/10.1089/jmf.2023.0178","url":null,"abstract":"<p><p>The present work focuses on studying the effectiveness of truffle extract administration to enhance memory functions in a scopolamine-induced amnesia mice model. Major phytochemical constituents, gallic acid and myricetin, underwent <i>in silico</i> studies using Autodock Vina and Discovery Studio visualizer software. Male mice were pretreated orally with either truffle extracts (400 mg/kg) or donepezil (3 mg/kg) for 21 days. Dementia was induced in mice by scopolamine (1 mg/kg) after 19 days of pretreatment and until day 28. The mice were divided into five experimental groups: (1) control; (2) model; (3) donepezil (1 mg/kg); (4) <i>Tirmania nivea</i> (400 mg/kg); and (5) <i>Terfezia boudieri</i> (400 mg/kg). Mice were subsequently subjected to a battery of behavioral tests, including an open field locomotor activity assay, and the Morris water maze (MWM) test. Biochemical, histopathological analyses and molecular docking were performed. Chronic Scopolamine administration decreased learning and memory enhancement during the MWM test. A significant increase in time to find the hidden platform and escape was observed. Scopolamine increases acetylcholinesterase (AChE) activity and oxidative stress. Conversely, treatment with the <i>T. nivea</i> and <i>T. boudieri</i> extracts (400 mg/kg orally administered) increased the memory of mice in the MWM task and suppressed scopolamine-induced oxidative damage. The memory enhancement effect was observed by the best docking scores of gallic acid and myricetin against AChE. This study reveals truffle's ameliorative effect on scopolamine-induced dementia in mice, possibly mediated by modulation of cholinergic activity and antioxidant activity. The docking of two major compounds, gallic acid and myricetin, predicted their potential as memory enhancers.</p>","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144015824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hypoglycemic Effect of Black Tea and Its Mechanism: Regulation of Glycometabolism and Intestinal Flora.","authors":"Fanglan Li, Hui Zhou, Jiangxiong Zhu, Xinlin Wei, Yuanfeng Wang","doi":"10.1089/jmf.2024.k.0251","DOIUrl":"10.1089/jmf.2024.k.0251","url":null,"abstract":"<p><p>This study aimed to investigate the hypoglycemic effects of different concentrations of black tea (BT) extracts and their underlying mechanisms in type 2 diabetic (T2DM) mice. Results indicated that BT extracts significantly mitigated weight loss, improved glucose and insulin tolerance, and modulated cytokine levels related to glucose and lipid metabolism in T2DM mice. Moreover, BT extracts ameliorated liver and pancreas damage resulting from high-sugar/high-fat diets and insulin resistance. Among the tested concentrations, low-concentration BT (BT-L) extract exhibited the most potent hypoglycemic ability. Furthermore, BT-L restored pancreatic function in hyperglycemic mice via activating the glucagon-like peptide-1 receptor-protein kinase A-pancreatic and duodenal homeobox-1-glucokinase cascade pathway. In terms of intestinal homeostasis, all BT-treated groups adjusted the gut microbiota structure by regulating the distribution and diversity of gut microbiota in T2DM mice. Among them, BT-L intervention specifically and significantly increased the levels of probiotic <i>Bifidobacterium</i> in the intestine of T2DM mice. Furthermore, BT-L intervention effectively promoted the synthesis of streptomycin by gut microbiota, thereby exerting anti-inflammatory effect. Comprehensively, the hypoglycemic effect of BT cannot show an absolute concentration-dependent relationship. Our findings highlight the potential of BT as an effective blood glucose regulator and provide valuable insights for BT-based functional food development.</p>","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":"435-447"},"PeriodicalIF":1.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143573278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anti-Inflammatory Effects of <i>Huberantha luensis and Ancistrocladus tectorius</i> Extracts Through Inhibition of Nuclear Factor-κB and Mitogen-Activated Protein Kinase Pathways.","authors":"Seong Ju Oh, Young Sun Jang, Eun-Ryoung Kim, Jun Il Kim, HyeBin Kim, YoungEun Kim, Chae Won Park, Hi Su Jang, The Bach Tran, Thu Thuy Nguyen, In-Kee Hong","doi":"10.1089/jmf.2024.k.0276","DOIUrl":"https://doi.org/10.1089/jmf.2024.k.0276","url":null,"abstract":"<p><p>Inflammation is a crucial response to harmful stimuli, but its chronic activation contributes to various diseases, including inflammatory bowel disease, osteoarthritis, and neurological disorders. While nonsteroidal anti-inflammatory drugs are widely used as anti-inflammation drugs, their extended usage often results in severe side effects, emphasizing the need for safer alternatives. Therefore, it is of the greatest importance to identify and discover new anti-inflammatory agents that exhibit a reduced incidence of adverse side effects. This study investigates the anti-inflammatory potential of methanol extracts from eight native Vietnamese plant species. These extracts were screened for their ability to inhibit nitric oxide production and pro-inflammatory cytokine expression in lipopolysaccharides-stimulated RAW264.7 macrophages. Among the tested extracts, those derived from <i>Huberantha luensis</i> (Pierre) Chaowasku and <i>Ancistrocladus tectorius</i> (Lour.) Merr. demonstrated notable reductions in NO, TNF-α, interleukin (IL)-1β, and IL-6 levels. Further analysis revealed that these extracts are abundant in polyphenols and flavonoids, compounds recognized for their anti-inflammatory effects. Furthermore, these extracts exerted their effects by inhibiting the kappa-light-chain-enhancer of activated B cells and mitogen-activated protein kinase signaling pathways, as evidenced by reduced phosphorylation of the proteins. These results suggest that the methanol extracts obtained from <i>H. luensis</i> and <i>A. tectorius</i> possess considerable potential in paving the way towards the innovative development of new therapeutic approaches aimed at alleviating chronic inflammation.</p>","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":"28 5","pages":"448-454"},"PeriodicalIF":1.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144015993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pharmacological Evaluation of Respiratory Safety Following a Single Intravenous Administration of Theophylline in Sprague-Dawley Rats.","authors":"Sung-Hyun Cho, Minseo Cho, Miae Doo, Jung-Heun Ha","doi":"10.1089/jmf.2024.k.0275","DOIUrl":"10.1089/jmf.2024.k.0275","url":null,"abstract":"<p><p>Drinking tea is an important cultural and sensory activity in modern society. However, tea consumption may influence biological functions because of its high polyphenol and methylxanthine content. Theophylline is a methylxanthine that plays a significant role in respiratory physiology and is used clinically as a bronchodilator. In this study, we assessed the pharmacological safety of theophylline by investigating its effects on the respiratory responses of experimental rodents. Six-week-old male Sprague-Dawley rats were intravenously administered 0, 2.5, 5, or 10 mg/kg theophylline. After systemic theophylline exposure, the respiratory rate, tidal volume, and minute volume were monitored and statistically analyzed. There was a significant increase in respiratory rate and minute volume with no change in tidal volume at theophylline doses of >5 mg/kg. Changes in respiratory rate and minute volume peaked at 0.25 h after exposure; the respiratory rate increased by 58.2% and 88.9%, and the minute volume increased by 50.5% and 72.8% with the 5 and 10 mg/kg doses, respectively, compared with the vehicle control. These results provide fundamental scientific data that can be used in clinical applications.</p>","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":"508-512"},"PeriodicalIF":1.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143189318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Mixture of Nicotinamide Mononucleotide, Decursin, and l-Cysteine Lowered Senescence-Associated Markers In Vitro and Was Effective Against 2,4-Dinitrochlorobenzene-Induced Atopic Dermatitis In Vivo: An Application of Network Pharmacology.","authors":"Hyo Ri Shin, La Yoon Choi, Seong Hwan Bae, Tae Gyun Kim, Hyung Taek Cho, Tae Jin Cho, Nam Su Oh, Youn Young Shim, Martin J T Reaney, Jeong Hoon Pan, Jeong-Oh Shin, Eui-Cheol Shin, Seong-Gyu Ko, Jinbong Park, Yohan Han, Kyung-Chul Choi, Young Jun Kim, Wan Heo, Kangwook Lee, Jae Kyeom Kim","doi":"10.1089/jmf.2024.k.0282","DOIUrl":"10.1089/jmf.2024.k.0282","url":null,"abstract":"<p><p>Skin aging, accelerated by oxidative stress from environmental factors, results in the breakdown of collagen and elastin, causing visible signs like wrinkles and inflammation. Natural antioxidants such as nicotinamide mononucleotide (NMN), decursin, and l-cysteine have shown potential in combating oxidative damage and inflammation. This study explored the effects of a formulated mixture of these compounds on skin aging and atopic dermatitis (AD) through a combination of <i>in vitro</i>, <i>in vivo</i>, and <i>in silico</i> methods. Using human keratinocyte cells, we assessed cytotoxicity via a cell viability assay, confirming NMN and l-cysteine were nontoxic up to 100 µM, while decursin exhibited toxicity above 10 µM. The intracellular oxidative stress measurement demonstrated that mixtures A and B, composed of the same concentrations of decursin and l-cysteine but differing in NMN levels (low in mixture A and moderate in mixture B), significantly reduced oxidative stress levels induced by 2,2'-azobis(2-amidinopropane) dihydrochloride, whereas mixture C, which contained the highest NMN concentration, was ineffective. Mixture B further reduced senescence-associated heterochromatin foci formation under oxidative stress, while mixture C caused cell structure disruptions. In the dinitrochlorobenzene-induced AD model in BALB/c mice, both, mixture-L and mixture-H treatments reduced epidermal thickness, scratching behavior, and transepidermal water loss, with mixture-L also lowering dermal thickness and mast cell infiltration. Gene expression analysis confirmed that mixture B decreased proinflammatory cytokines like <i>TNF-α</i> and <i>IL-6</i>, while network pharmacology predicted key antioxidant pathways, validated through restored <i>NOS2</i> gene expression. Overall, the findings highlight the potential of these compound mixtures to mitigate oxidative stress and inflammation, offering a promising approach for skin aging and dermatitis management, though further validation is needed to optimize efficacy and safety.</p>","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":"490-500"},"PeriodicalIF":1.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143699562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bioimpedance Phase Angle as a Diagnostic Tool of Nutritional Status in Children with Crohn's Disease on Exclusive Enteral Nutrition Therapy: One-Year Follow-Up Study.","authors":"Agata Wasilewska, Przemysław Tomasik, Aleksander Gałaś, Anna Stochel-Gaudyn, Dorota Drożdż, Krzysztof Fyderek, Małgorzata Sładek","doi":"10.1089/jmf.2023.0242","DOIUrl":"10.1089/jmf.2023.0242","url":null,"abstract":"<p><p>Exclusive enteral nutrition (EEN) is highly effective in achieving remission and improving nutritional status in pediatric Crohn's disease (CD), commonly associated with altered body mass composition (BC). Bioimpedance analysis (BIA) with phase angle (PA) assessment is a noninvasive, reliable tool in screening for BC alterations. In the present study we aimed to assess the PA's usefulness in the detection of malnutrition in newly diagnosed pediatric CD, ongoing EEN treatment, and during 1-year follow-up. Patients and study design: Fourty-three patients with CD, qualified for EEN, were enrolled in the study. Additionally, 22 healthy children, being in the same age category, served as controls. Fat-free mass (FFM), fat-free mass index (FFMI), and BIA-derived PA were assessed at diagnosis, after EEN completion, and at week 52. The same parameters were obtained in the control group once. The majority of patients presented with normal body mass index at diagnosis. PA values were lower than 5 degrees in 65% of the study group. FFMI deficiencies were observed in 74% of patients. After EEN completion, an increase in FFM (<i>P</i> < .001) was observed. The highest mean of FFM (<i>P</i> < .001) and PA (<i>P</i> < .001) were observed at week 52. A strong correlation between PA and FFM at CD diagnosis (Spearman's rho = 0.671, <i>r</i> = 0.702, <i>P</i> < .001), after EEN completion (Spearman's rho = 0.781, <i>P</i> < .00) and at week 52 (Spearman's rho = 0.657, <i>P</i> < .001) was present. PA has been observed as positively associated with albumin concentrations both at diagnosis and after EEN. Our study provides some support that PA may be a reliable tool for screening alteration in BC, especially FFM and lean tissue mass (LTM). Moreover, PA has been observed as positively associated with albumin levels at CD diagnosis, which provides some evidence that it may be considered as a risk indicator of malnutrition and protein deficiency in newly diagnosed CD pediatric patients.</p>","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":"501-507"},"PeriodicalIF":1.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143780256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>Centella Asiatica</i> Fraction-3 Enhances Antioxidant Capacity and Apoptotic Cell Death in HEK293 Kidney Cells.","authors":"Dhaneshree B Naidoo, Alisa Phulukdaree, Anil Armichund Chuturgoon, Vikash Sewram","doi":"10.1089/jmf.2022.0109","DOIUrl":"10.1089/jmf.2022.0109","url":null,"abstract":"<p><p>The traditional medicinal plant <i>Centella asiatica</i> is commonly used in Chinese and Ayurvedic medicine due to its vast range of therapeutic properties. Previously, the ethanolic <i>C. asiatica</i> leaf extract was subjected to silica column fractionation, and the C3 fraction was obtained. We investigated the antioxidant and anti-proliferative effects of C3 in human embryonic kidney (HEK293) cells. In HEK293 cells, C3 cytotoxicity was assessed (viability assay; 24 h; [0.2-3 mg/mL]), and a half maximal inhibitory concentration (IC₅₀) was determined. Malondialdehyde (MDA), lactate dehydrogenase (LDH) (spectrophotometry), mitochondrial depolarization (<i>Δψ</i>_m), intracellular reactive oxygen species (flow cytometry), glutathione (GSH), oxidized glutathione (GSSG) concentrations, caspase activities, ATP levels (luminometry), and fragmentation of DNA (SCGE assay) were evaluated. Protein expressions were assessed by western blotting. Gene expressions were quantified by qPCR. Cell viability in HEK293 cells was decreased in a dose-dependent manner by C3. MDA, <i>Δψ</i>_m, LDH, caspase activities, and DNA fragmentation (<i>P</i> < .0004) were significantly increased by C3. Nuclear factor erythroid 2-related factor 2 (Nrf-2) protein expression, GSH, and GSSG concentrations were increased, whereas antioxidant (<i>Nrf-2</i>, <i>GPx</i>, <i>SOD,</i> and <i>CAT</i>) gene expression was significantly decreased by C3 (<i>P</i> < .001). C3 decreased both Bax and Bcl-2 protein expression (<i>P</i> < .03). Gene expression of <i>c-myc</i> was significantly increased, whereas <i>OGG-1</i> was significantly reduced by C3 (<i>P</i> < .05). C3 reduced antioxidant gene expression, increased antioxidant levels, and elevated anti-proliferative effects in HEK293 cells, suggesting that high concentrations of C3 are potentially toxic to kidney cells, thus rendering cause for concern with its human use.</p>","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":"455-464"},"PeriodicalIF":1.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143753178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fermented Strawberry (<i>Fragaria x Ananassa</i> Duch.) Mitigates Renal Fibrosis in a Unilateral Ureteral Obstruction Model by Reducing Inflammation, Oxidative Stress, and Regulating Smad Signaling.","authors":"Chia-Chu Chang, Erl-Shyh Kao, Yi-Chen Lee, Huei-Jane Lee","doi":"10.1089/jmf.2024.k.0257","DOIUrl":"https://doi.org/10.1089/jmf.2024.k.0257","url":null,"abstract":"<p><p>Renal fibrosis is a common outcome in many progressive renal diseases. Unilateral ureteral obstruction (UUO) is known to induce oxidative stress and inflammation in the kidneys, leading to the development of renal fibrosis. Fermented strawberry (<i>Fragaria x ananassa Duch.</i>) possesses antioxidant properties; however, its effect on renal fibrosis remains unclear. This study aimed to evaluate the impact of fermented strawberry dry powder (FSP) on renal fibrosis by assessing proinflammatory cytokines, oxidative stress markers, and underlying mechanisms. Male Sprague-Dawley rats were subjected to UUO surgery to induce tubulointerstitial fibrosis and obstructive nephropathy. Ten days postsurgery, the rats were randomly divided into four groups (<i>n</i> = 6), including a sham-operated control group. FSP was administered orally at doses of 0.05 or 0.5 g kg^-1 body weight daily for 21 days. FSP treatment significantly improved renal function, reduced tubular dilation, and decreased interstitial volume in UUO rats. FSP decreased levels of tumor necrosis factor-α and interleukin-6, while enhancing the activities of antioxidant enzymes such as superoxide dismutase and catalase. Treatment with 0.05 and 0.5 g kg^-1 FSP resulted in a reduction of collagen deposition in the kidneys by 49% and 69%, respectively, compared with UUO group. FSP increased E-cadherin expression and decreased α-smooth muscle actin level in the kidneys of UUO rats. Furthermore, FSP reduced transforming growth factor-β and Smad2/3 levels while upregulating Smad7 expression. These findings suggest that FSP mitigates renal tubulointerstitial fibrosis, likely through modulation of Smad signaling and attenuation of oxidative stress and inflammation.</p>","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":"28 5","pages":"423-434"},"PeriodicalIF":1.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143972042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bioactive Properties of Murici (<i>Byrsonima crassifolia</i>) and Bacuri (<i>Platonia insignis</i>) and Their Antioxidant and Anti-Inflammatory Effects in Rats.","authors":"Raquel Martins Martinez, Audrey Cristina Cintra, Carolina de Oliveira Ramos Petra de Almeida, Thuane Passos Barbosa Lima, Isabelle Moraes de Souza, Matheus Augusto Patrício de Almeida, Stephan Pinheiro Frankenfeld, Fabio Luiz Cândido Cahuê, Gabriela de Queiroz Pereira Lopes, Verônica Salerno Pinto, Adriana Ribeiro Silva, Cassiano Felippe Gonçalves-de-Albuquerque, Manuela Dolisnky, Anderson Junger Teodoro","doi":"10.1089/jmf.2023.0029","DOIUrl":"https://doi.org/10.1089/jmf.2023.0029","url":null,"abstract":"<p><p>Fruit consumption favors energy balance, ensures essential nutrients, and provides bioactive compounds with antioxidant and anti-inflammatory activities capable of preventing and treating noncommunicable diseases. Tremendous Brazilian biodiversity favors countless fruit and vegetable crops, including exotic fruits. This study aimed to describe the nutritional characteristics of murici and bacuri and their effects on oxidative stress and inflammation. The murici lyophilized extract (MLE) and bacuri lyophilized extract (BLE) were evaluated for their antioxidant activity and total phenolic compounds content. Healthy female Wistar rats were divided into control and supplemented groups (50, 100, and 250 mg/kg body weight) for each fruit, with a 14-day supplementation. Parameters of oxidative damage and antioxidant system in plasma and inflammatory biomarkers in the kidney and liver tissues were evaluated. Murici has carotenoids as the main bioactive compound, whereas bacuri is a source of polyphenols, with relevant antioxidant activity for human health. Treatment with MLE in healthy rats resulted in increased plasma antioxidant capacity measured by DPPH assay, reduced plasma levels of lipid peroxidation (TBARS) and carbonylated proteins, and lower TNF-α production in the kidney and liver. BLE supplementation reduced plasma lipid peroxidation levels and led to lower activity of IL-1 β, IL-6, and TNF-α in supplemented animals' kidneys. Both fruits showed positive antioxidant and anti-inflammatory effects against oxidative stress and inflammation in an <i>in vivo</i> model. The results point to new antioxidant and anti-inflammatory resources to be studied.</p>","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":"28 5","pages":"478-489"},"PeriodicalIF":1.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144007167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Review of the Effects of Flavonoids on NAD(P)H Quinone Oxidoreductase 1 Expression and Activity.","authors":"Erik B Froyen, Gianluis Pimentel Barrantes","doi":"10.1089/jmf.2023.0132","DOIUrl":"10.1089/jmf.2023.0132","url":null,"abstract":"<p><p>Cancer is a significant cause of death worldwide. It has been suggested that the consumption of flavonoids decreases the risk for cancer by increasing phase II enzymes, such as Nicotinamide Adenine Dinucleotide Phosphate Hydrogen (NAD(P)H) quinone oxidoreductase 1 (NQO1), glutathione S-transferases, and Uridine 5'-diphospho- (UDP)-glucuronosyltransferases that assist in removing carcinogens from the human body. Flavonoids are bioactive compounds found in a variety of dietary sources, including fruits, vegetables, legumes, nuts, and teas. As such, it is important to investigate which flavonoids are involved in the metabolism of carcinogens to help reduce the risk of cancer. Therefore, the objective of this narrative review was to investigate the effects of commonly consumed flavonoids on NQO1 mRNA expression, protein, and activity in human cell and murine models. PubMed was used to search for peer-reviewed journal articles, which demonstrated that selected flavonoids (<i>e.g.</i>, quercetin, apigenin, luteolin, genistein, and daidzein) increase NQO1, and therefore, increase the excretion of carcinogens. However, more research is needed regarding the mechanisms by which flavonoids induce NQO1. Furthermore, it is suggested that future efforts focus on providing precise flavonoid recommendations to decrease the risk factors for chronic diseases.</p>","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":"407-422"},"PeriodicalIF":1.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143649329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}