Journal of medicinal food最新文献

{"title":"<i>Lactiplantibacillus plantarum</i> Q180 Mitigates Early High-Fat Diet-Induced Metabolic Dysfunction-Associated Steatotic Liver Disease by Modulating Gut-Liver Axis Inflammation and Barrier Integrity.","authors":"Yeon-Woo Kim, Hyunchae Joung, Hyunsoo Jang, Jiwoo Lee, Ji-Woo Lee, Yoo Jin Kwon, Chang Hun Shin, Jisu Lee, Jung-Heun Ha","doi":"10.1177/1096620X261481601","DOIUrl":"https://doi.org/10.1177/1096620X261481601","url":null,"abstract":"<p><p>Metabolic dysfunction-associated steatotic liver disease (MASLD) develops through systemic metabolic dysregulation and gut-liver axis-mediated inflammation; however, effective preventive strategies remain limited. Probiotics such as <i>Lactiplantibacillus plantarum</i> have emerged as potential modulators of intestinal barrier integrity and hepatic inflammation; however, preventive efficacy during early MASLD progression has not been fully elucidated. The present study evaluated whether <i>L. plantarum</i> Q180 attenuates early high-fat diet (HFD)-induced MASLD in a murine model. Male C57BL/6J mice were fed a normal diet or 60% HFD for 12 weeks, and Q180 was orally administered at 1.0 × 10⁹ CFU/day from weeks 5 to 12. HFD feeding induced obesity, hepatic lipid accumulation, and an elevated nonalcoholic fatty liver disease activity score (NAS), confirming early-stage MASLD. Although Q180 did not significantly reduce body weight gain or adipose tissue mass, Q180 did significantly decrease hepatic triglyceride levels and NAS, accompanied by improvements in steatosis, hepatocellular ballooning, and inflammatory infiltration. Hepatic expressions of <i>Dgat1</i> and <i>Sod</i> were significantly upregulated, whereas <i>Ldlr</i> expression was downregulated. In the colon, Q180 markedly suppressed <i>Tnf-α</i> and <i>Il-6</i> expression and partially restored <i>Zo-1</i>, <i>Occludin</i>, and <i>Muc2</i> expressions. Serum endotoxin levels were significantly reduced, and a decreasing trend was observed in fecal endotoxin levels. Overall, Q180 exerted metabolic and immunological benefits during early MASLD progression by reducing hepatic lipid accumulation, enhancing antioxidant defenses, attenuating intestinal inflammation, reinforcing intestinal barrier integrity, and lowering endotoxin exposure. The results support Q180 as a promising probiotic candidate for the prevention and early management of MASLD through gut-liver axis modulation.</p>","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":"1096620X261481601"},"PeriodicalIF":1.8,"publicationDate":"2026-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148813387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combined Extracts of <i>Actinidia arguta</i>and <i>Perilla frutescens</i>, HX114, Exert Photoprotective Effects on Epidermal Barrier Function and Dermal Matrix Integrity in UVB-Irradiated Hairless Mice.","authors":"Dahyeon Kim, Dongkyu Kim, Ju-Young Lee, Kun-Pyo Kim, Yunhi Cho","doi":"10.1177/1096620X261479617","DOIUrl":"https://doi.org/10.1177/1096620X261479617","url":null,"abstract":"<p><p>Extracts of <i>Actinidia arguta</i> (hardy kiwi) and <i>Perilla frutescens</i>, which are rich in rosmarinic acid (RA) and hyperoside, are known to alleviate skin dryness; however, their photoprotective effects remain largely unclear. This study investigated the comprehensive effects of HX114, a combined extract of <i>A. arguta</i> fruit and <i>P. frutescens</i> leaves, on the epidermal barrier and dermal structure in UVB-irradiated SKH-1 hairless mice. The mice were fed HX114-supplemented diets (200, 400, or 800 mg/kg body weight or 1% in the diet) for 10 weeks, concurrent with UVB exposure. Skin health parameters-hydration, transepidermal water loss (TEWL), pH, and wrinkle indices-and key molecular factors and their processing enzymes were evaluated. UVB irradiation significantly impaired both the skin health parameters and key molecular factors. Conversely, HX114 supplementation restored all skin health parameters, showing dose-dependent improvements in hydration, TEWL, epidermal thickness, and wrinkle area. Concurrently, HX114 increased total epidermal free amino acid (FAA) levels and dose-dependently elevated the expression of filaggrin (FLG), peptidylarginine deiminase 3, and caspase-14. In addition, total ceramide levels increased in parallel with reduced aCDase expression. In the dermis, HX114 enhanced type I collagen (COL1) levels, which was accompanied by dose-dependent reductions in matrix metalloproteinase (MMP)1/MMP13 and increased tissue inhibitor of metalloproteinase 1 expression; it also dose-dependently increased hyaluronic acid (HA) levels. Furthermore, FAAs, FLG, and HA correlated strongly with skin hydration, TEWL, and pH, and COL1 correlated with wrinkle area and length. Notably, the skin health parameters were significantly interrelated, indicating a holistic protective effect. HX114, containing RA and hyperoside, appears to protect against photodamage by synergistically improving both epidermal barrier function and dermal structural integrity.</p>","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":"1096620X261479617"},"PeriodicalIF":1.8,"publicationDate":"2026-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148794291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Review of the Antioxidant, Anti-Inflammatory, and Immunomodulatory Properties of <i>Baccharis dracunculifolia</i>.","authors":"Grazieli Beatriz de Oliveira Gonçalves, Marcos Adriano Carlos Batista, Renata Maria Leal de Souza, João Pedro Mendes Moura, Isabela Jesus de Deus, Sílvia Paula-Gomes, Sandra Aparecida Lima de Moura, Leonardo Máximo Cardoso, Carla Speroni Ceron","doi":"10.1177/1096620X261474397","DOIUrl":"https://doi.org/10.1177/1096620X261474397","url":null,"abstract":"<p><p><i>Baccharis dracunculifolia</i>, the main botanical source of Brazilian green propolis, has gained prominence as a versatile medicinal species due to its rich profile of phenolic acids, flavonoids, and terpenoids with recognized antioxidant and anti-inflammatory properties. This review synthesizes experimental evidence on how different preparations of <i>B. dracunculifolia</i>, including hydroalcoholic, ethanolic, glycolic, methanolic, <i>n</i>-hexane and ethyl acetate extracts, and essential oil, modulate redox balance, inflammatory, and immunomodulatory responses <i>in vitro</i> and <i>in vivo</i>. Emphasis is placed on metabolites such as caffeic and <i>p</i>-coumaric acids, artepillin C, baccharin, isosakuranetin, and nerolidol, which contribute to reactive oxygen species scavenging, preservation of mitochondrial function, reinforcement of endogenous antioxidant defenses, and inhibition of enzymes like myeloperoxidase, nicotinamide adenine dinucleotide phosphate oxidase oxidase, and cyclooxygenase-2. The impact of seasonality, plant part, solvent, and extraction technique on phytochemical composition and mechanisms of biological activity is presented in preclinical models of colitis, gastric ulcer, arthritis, hepatotoxicity, cardiometabolic syndrome, diabetes, and inflammatory skin diseases, in which treatment with extracts of <i>B. dracunculifolia</i> attenuates leukocyte recruitment, tissue edema, oxidative damage, and production of pro-inflammatory cytokines. Finally, <i>B. dracunculifolia</i> is a promising phytotherapeutic resource with potential applications ranging from complementary treatments for inflammatory and oxidative stress-related disorders.</p>","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":"1096620X261474397"},"PeriodicalIF":1.8,"publicationDate":"2026-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148689271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nowarta110 Displays Antiviral Properties Against Coxsackievirus B and Herpes Simplex Virus 2.","authors":"Jon Sin, Hong-An Tran, Thanh X Hoang, Anh K Nguyen, Ferre Akbarpour, Bo Han, Ba X Hoang","doi":"10.1177/1096620X261427691","DOIUrl":"10.1177/1096620X261427691","url":null,"abstract":"<p><p>Nowarta110 is a novel fig extract and colloidal silver therapeutic composition initially designed to treat plantar warts caused by human papilloma virus (HPV). In a recent study, we also demonstrated that our nutraceutical formulation exhibits potent antitumoral activity in mice xenografted with HPV-transformed cells. Fig extracts have been shown to provide antiviral effects toward a number of viruses; thus, to explore Nowarta110's potential antiviral activity, we evaluated its impact on <i>in vitro</i> models of both Coxsackievirus B (CVB) and herpes simplex virus type 2 infections. We found that Nowarta110 significantly reduced infection of human cells with both CVB and herpes simplex virus 2. In all, these findings demonstrate that Nowarta110 possesses antiviral properties against a broad range of viruses. Thus, further studies interrogating its antiviral therapeutic potential are warranted.</p>","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":"498-501"},"PeriodicalIF":1.8,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147355503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Supplemental Lycopene Reduces Feed Intake, Increases Fluid Consumption, and Enhances Bone and Stomach Growth in Growing Wistar Rats Fed a High-Fructose Diet.","authors":"Mercy Omoye Shafe, Nontobeko Myllet Gumede, Trevor Tapiwa Nyakudya, Eliton Chivandi","doi":"10.1177/1096620X251409053","DOIUrl":"10.1177/1096620X251409053","url":null,"abstract":"<p><p>Dietary modification in early life can either increase susceptibility or improve resistance to metabolic diseases in adulthood. This study evaluated the potential of lycopene to mitigate metabolic derangements caused by a high-fructose diet in rats mimicking adolescents fed a high-fructose diet. Ninety-six weanling Wistar rats (male and female, aged 21 days) were randomly allocated to six treatment groups: (1) standard rat chow (SRC), plain drinking water (PDW), and plain gelatin cubes (PG); (2) SRC + PDW + 20% fructose solution (FS); (3) SRC + FS + 100 mg/kg fenofibrate (FENO) + PG; and (4-6) SRC + FS with lycopene at 30, 60, and 100 mg/kg/day, respectively, for 12 weeks. Body mass, feed, and fluid intake were measured twice weekly. At termination, rats were fasted overnight, weighed, euthanized, and assessed for gastrointestinal viscera, femora, and tibiae parameters, including mass and length, with bone mass-to-length ratios computed. The rats grew significantly (<i>P</i> < .05) during the trial. Control males had higher mean weekly body mass than medium-dose lycopene-supplemented rats (weeks 3-4) and fenofibrate-treated rats (weeks 10-12), and higher terminal body mass than fructose-fed and fenofibrate groups (<i>P</i> < .05). In both sexes, controls had greater total feed intake (TFI) than all groups (<i>P</i> < .05). Lycopene reduced TFI but increased fluid intake compared with control and fenofibrate-treated groups (<i>P</i> < .05). Fenofibrate increased total calorie intake in females compared with all groups and in males compared with fructose-fed and lycopene-supplemented groups (<i>P</i> < .05). Lycopene-supplemented males had heavier femora and longer tibiae than fenofibrate-treated counterparts (<i>P</i> < .05). Medium- and high-dose lycopene increased stomach mass in males compared with controls, while low-dose lycopene reduced small intestine mass compared with fenofibrate (<i>P</i> < .05). Lycopene may support bone health, enhance gastric function, and prevent fenofibrate-induced bone loss in male Wistar rats.</p>","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":"471-484"},"PeriodicalIF":1.8,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147498857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>Lachnum singerianum</i> Polyphenols Alleviate Hyperglycemia in Streptozotocin-Induced Diabetic Mice via the IRS/Akt/GSK-3β Pathway.","authors":"Ning Sun, Xue Chen, Tingting Chen, Ming Ye, Shuai Zong","doi":"10.1177/1096620X261449339","DOIUrl":"10.1177/1096620X261449339","url":null,"abstract":"<p><p>This study evaluated the antihyperglycemic effects and mechanisms of <i>Lachnum singerianum</i> polyphenols (LPs) in streptozotocin-induced diabetic mice. LP was obtained via ethanol extraction, purified using XAD-4 resin, and characterized by LC-MS/MS. Diabetic mice were administered low- or high-dose LP (50 or 100 mg/kg), metformin, or their combination for 6 weeks. Metabolic parameters, organ indices, serum and liver biomarkers, histopathology, and signaling pathways were assessed. Liquid chromatography-tandem mass spectrometry (LC-MS/MS) identified LP as flavonoid-, tannin-, and phenolic acid-enriched fractions. LP treatment significantly ameliorated hyperglycemia, as evidenced by reduced fasting blood glucose, improved glucose and insulin tolerance, and restored homeostasis model assessment indices. Furthermore, LP alleviated hepatic injury, attenuated oxidative stress, and ameliorated dyslipidemia, with histopathological analysis confirming protective effects on pancreatic islets and liver tissues. Mechanistically, LP activated the insulin receptor substrate (IRS)/protein kinase B (Akt)/glycogen synthase kinase (GSK)-3β pathway by enhancing IRS-2/Akt phosphorylation and suppressing GSK-3β expression. This is the first study to characterize the bioactive polyphenols from <i>L. singerianum</i> and demonstrate their multitarget efficacy against diabetic hyperglycemia through coordinated modulation of insulin resistance, oxidative stress, and lipid metabolism.</p>","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":"531-542"},"PeriodicalIF":1.8,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147864015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immuno-Enhancing Effects and Minimum Effective Dose of the Co-Extracted Herbal Formulation JI-HK601 via NK Cell Activation.","authors":"Sang-Eun Lee, Young Ha Kim, Yun-Beom Sim, Seong-Gyu Ko","doi":"10.1177/1096620X261450801","DOIUrl":"10.1177/1096620X261450801","url":null,"abstract":"<p><p>This study compared the immunomodulatory effects of the co-extracted herbal formulation JI-HK601 with those of an individual extracts mixture (IEM) and evaluated the minimum effective dose of JI-HK601 through <i>in vivo</i> immune function analyses in mice. To assess safety, both extracts were administered orally at a dose of 400 mg/kg for 14 consecutive days. Measurements of body weight, spleen index, and peripheral blood cell profiles revealed no significant differences compared to the normal control group, suggesting that neither extract induced systemic toxicity or abnormal immune organ responses under the tested conditions. Immunological assessments indicated that JI-HK601 enhanced natural killer (NK) cell cytotoxic activity to a greater extent than IEM, suggesting a greater functional improvement in NK cell responsiveness. In subsequent dose-response studies of JI-HK601, no toxicity was observed at any dose, whereas increases in T-cell proportion and NK cell activity were noted at 400 mg/kg. Analysis of T-cell transcription factors showed selective upregulation of T-box transcription factor 21 (T-bet), a key regulator of T helper type 1 (Th1) differentiation. These results indicate that JI-HK601 preferentially stimulates Th1-associated immune pathways while enhancing innate cytotoxic function. Overall, the findings demonstrate that JI-HK601 strengthens NK cell activity and promotes Th1-related cellular immunity while maintaining a favorable safety profile across the evaluated dose range. Thus, these results provide foundational data for assessing the potential use of JI-HK601 as an immune-enhancing ingredient in functional foods and complementary and alternative medicine.</p>","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":"543-550"},"PeriodicalIF":1.8,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147874458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stimulatory Effects of (+)-Epicatechin on Mitochondrial Biogenesis and Function in Skeletal Muscle of Aged Rats: Underlying Mechanisms.","authors":"Israel Ramirez-Sanchez, Rosa Ordoñez-Razo, Veronica Najera, Guillermo Ceballos, Francisco Villarreal","doi":"10.1177/1096620X261421080","DOIUrl":"10.1177/1096620X261421080","url":null,"abstract":"<p><p>Mitochondrial dysfunction affects skeletal muscle (SkM) function and is critical in the etiology of age-related sarcopenia. The sirtuin 1-PGC1α pathway is a key regulator of mitochondrial mass, structure, and function. However, pathway activity decreases with aging. Cacao flavanols show promise in their ability to activate mitochondrial pathways. We evaluated the capacity of the flavanol (+)-epicatechin (+Epi) to stimulate such a pathway and favorably impact mitochondrial and oxidative stress (OS)-associated endpoints in aged SkM. Using 23-month-old male Sprague-Dawley rats, an 8-week oral administration of +Epi (1 mg/kg/day) was implemented, and results were compared versus vehicle-treated controls. Assessments included the nicotinamide adenine dinucleotide (NAD)/sirtuin 1/PGC1α pathway, acetylated proteins levels, mitochondrial function and biogenesis, as well as OS-related endpoints in SkM. +Epi increased the NAD/NADH ratio, activation of sirtuin 1, the deacetylation of nuclear protein content, including that of PGC1α. Also, +Epi induced increases of TFAM and NRF1 mRNA levels, deacetylation of mitochondrial complex I and V, increases in complex I activity, sirtuin 3, complexes I and V, mitofilin, and TFAM protein levels. SkM citrate synthase activity and ATP content increased with +Epi. OS markers in proteins and lipids were reduced, while buffering systems (superoxide dismutase 2 and catalase protein and activities) increased. In white blood cells, we documented serial reductions in mitochondrial DNA content and citrate synthase activity with aging, which were either fully or partially reversed with +Epi. Results demonstrate that +Epi treatment yields positive effects on mitochondrial biogenesis and function, leading to decreased OS and improved SkM bioenergetics in aged rats.</p>","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":"489-497"},"PeriodicalIF":1.8,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146118541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Structure-Guided Preference Feeding Behavioral Responses of Coumarin Analogs in <i>Caenorhabditis elegans</i>.","authors":"Aaron Taehwan Kim, Yeonhwa Park","doi":"10.1177/1096620X261416760","DOIUrl":"10.1177/1096620X261416760","url":null,"abstract":"<p><p>Coumarins are a group of naturally occurring phytochemicals found in various plants with many bioactivities. Recently, it was reported that esculetin (6,7-dihydroxycoumarin) reduced food preference behavior of <i>Caenorhabditis elegans</i> dependent on the human µ-opioid receptor (MOPR). Thus, this study investigated the structure-activity relationships (SAR) of 17 coumarin analogs using a food preference assay in <i>C. elegans</i>. While the parent compound, coumarin, and single substitutions at C3, C5, C7, or C8 had no effect, modifications at C4 and C6 were critical for modulating this behavior. Specifically, 4-hydroxycoumarin, 4-methylcoumarin, 6-hydroxycoumarin, 4-hydroxy-6-methylcoumarin, 6,7-dihydroxycoumarin (esculetin), 7-hydroxy-6-methoxycoumarin (scopoletin), and several di-substituted derivatives significantly reduced the preference index, which was abolished in <i>npr-17</i> (opioid receptor homolog) knockout strains. Additional determination of preference behaviors was conducted with a strain carrying the human MOPR, which showed results comparable to the wildtype, except for 4-hydroxy-6-methylcoumarin and scopoletin. This work demonstrates the potential antagonistic effects of selected coumarins and the utility of <i>C. elegans</i> as an <i>in vivo</i> model for SAR studies targeting human MOPR.</p>","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":"485-488"},"PeriodicalIF":1.8,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146040951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Review on <i>In Silico</i> Evaluation of Flavonoids as Potential Pharmaceutical Ingredients.","authors":"Sinan Simsek, Emel Akyol, Ilknur Kucuk","doi":"10.1177/1096620X261430296","DOIUrl":"10.1177/1096620X261430296","url":null,"abstract":"<p><p>Flavonoids have antioxidant, antibacterial, and anti-inflammatory properties and are promising candidates for therapeutic and health-promoting applications. The effects of bioactive compounds on health are contingent upon their ingestion and bioavailability. The impact of flavonoids on humans and their potential as food supplements can often be predicted using <i>in silico</i> ADMET (absorption, distribution, metabolism, excretion, and toxicity) modeling. The aim of this review is to examine the drug-like properties of flavonoids using SwissADME and evaluate their pharmaceutical potential as supplements. In the future, flavonoids are expected to find wider use not only as food preservatives or colorants but also as functional food ingredients and nutraceutical supplements. Trends in personalized nutrition, healthy aging, and strategies for chronic disease prevention will particularly enhance the value of flavonoids. However, for this potential to be realized, clarification of regulations, strengthening of toxicological data, and intensifying collaboration between industry and academia are crucial.</p>","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":"517-530"},"PeriodicalIF":1.8,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147444135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}