Journal of medicinal food最新文献

{"title":"Oral Collagen Oligopeptides as a Modulator of Skin Health: A Comprehensive Evaluation of Clinical and Molecular Effects.","authors":"Vivian Zague, Ana Lucia Tabarini Alves Pinheiro, Juliana Rodrigues Pinto, Gustavo Facchini, Samara Eberlin","doi":"10.1089/jmf.2024.0252","DOIUrl":"10.1089/jmf.2024.0252","url":null,"abstract":"<p><p>Collagen peptides (CPs) have been recognized for their potential to enhance skin health, particularly by improving hydration, firmness, and elasticity. However, the molecular mechanisms driving these benefits remain not fully understood, especially regarding their influence on essential extracellular matrix (ECM) components and enzymes that regulate collagen turnover. This study investigated both the clinical efficacy and the underlying preclinical molecular effects of oral collagen oligopeptides (Col-OP) supplementation, aiming to clarify how these peptides contribute to skin improvements. In clinical trials, a double-blind, randomized, placebo-controlled study with 85 women aged 45-60 years examined the effects of daily 2.5 g Col-OP supplementation over 84 days, measuring skin hydration (Corneometer®), firmness, and elasticity (Cutometer®). In addition to clinical studies, preclinical <i>in vitro</i> experiments were conducted on human dermal fibroblast cultures to elucidate the molecular effects of Col-OP. Fibroblasts were treated with noncytotoxic concentrations of Col-OP (10.0, 3.16, and 1.0 mg/mL) for 96 h, assessing the synthesis of type I collagen, matrix metalloproteinase-1 (MMP-1), tissue inhibitor of matrix metalloproteinases (TIMP-1), decorin, versican, biglycan, and hyaluronic acid (HA) through gene expression and enzyme-linked immunosorbent assays. Results showed that Col-OP treatment significantly enhanced gene expression of type I procollagen, decorin, and biglycan while decreasing versican levels (<i>P</i> < .001). It also promoted type I collagen synthesis and TIMP-1 levels, modulating MMP-1 and HA production. Clinically, Col-OP significantly enhanced skin firmness and elasticity compared with placebo (<i>P</i> < .05), while improvements in skin hydration did not achieve statistical significance. Based on the current data, it can be concluded that oral supplementation with Col-OP effectively enhances skin health by promoting key ECM components and modulating collagen turnover, offering a promising approach for improving skin health.</p>","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":"869-876"},"PeriodicalIF":2.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144302242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genotoxicity Evaluation of Biokesum® <i>Polygonum minus</i> (<i>Persicaria Minor</i>) Standardized Extract Using Bacterial Reverse Mutation, <i>In Vitro</i> Micronucleus, and <i>In Vitro</i> Chromosomal Aberration Studies.","authors":"Jennifer Ator, Mitchell Kelly, Rekha Shivaram, Rakesh Chikkagundagallu Krisnamurthy, Yogini Pradip Soman, Margaret H Whittaker","doi":"10.1089/jmf.2024.0255","DOIUrl":"10.1089/jmf.2024.0255","url":null,"abstract":"<p><p><i>Persicaria minor</i> is a shrub native to Southeast Asia that is commonly known as \"kesum.\" Its leaf extract is used medicinally and in dietary supplements. To add to the overall toxicological dataset, Biokesum® <i>Polygonum minus</i> (<i>Persicaria minor</i>) standardized extract was tested in a battery of guideline genotoxicity tests, namely the OECD Guideline 471 bacterial reverse mutation test, the OECD Guideline 473 <i>in vitro</i> mammalian cell chromosomal aberration test, and the OECD Guideline 487 <i>in vitro</i> micronucleus assay. The use of multiple standardized, validated assays increases the overall predictive value relative to individual assays and provides greater confidence in the test results. All three assays were negative, demonstrating that Biokesum® is not genotoxic.</p>","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":"877-884"},"PeriodicalIF":2.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144302241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>Crataegus songarica</i> Fruit Ameliorates Oxidative Stress, Hypertension, and Endothelial Dysfunction in Glucose-Induced Hypertensive Rats.","authors":"Waqas Younis, Alamgeer Alamgeer, Muhammad Nasir Hayat Malik, Tariq G Alsahli, Wajiha Manzoor, Muhammad Majid, Malik Zahid Imran, Muryam Abdul Razzaq, Alana Anne Kaneda Garcia, Emerson Luiz Botelho Lourenço, Aline Aparecida Macedo Marques, Arquimedes Gasparotto Junior","doi":"10.1089/jmf.2023.0115","DOIUrl":"10.1089/jmf.2023.0115","url":null,"abstract":"<p><p><i>Crataegus songarica</i> is a native species of Pakistan. Its fruits are locally consumed for the treatment of various cardiovascular disorders, including hypertension, heart failure, and vascular insufficiency. Despite its traditional use, data regarding its effectiveness remain unclear. Therefore, the aim of the study was to evaluate the cardioprotective effects of <i>C. songarica</i> fruit extract on glucose-induced hypertensive rats. First, the aqueous-methanol extract (AMECS) was obtained and subjected to phytochemical characterization. The antioxidant and cytotoxic properties were investigated <i>in vitro</i>. Acute toxicity as well as screening for hypotensive effects was also evaluated. The cardioprotective effects were assessed in glucose-induced hypertensive rats after 21 days of treatment with AMECS (500 mg/kg single-daily oral dose). At the conclusion of the treatments, we investigated hemodynamic and biochemical parameters as well as endothelium-dependent vascular reactivity and tissue redox state. AMECS exhibited a significant antioxidant effect <i>in vitro</i>. In addition, no evidence of acute toxicity was observed. In glucose-induced hypertensive rats, AMECS prevented the increase in systolic blood pressure, oxidative stress, endothelial dysfunction, and metabolic alterations induced by glucose. The data obtained led us to conclude that the fruit extract of <i>C. songarica</i> presents a significant cardioprotective effect in glucose-induced hypertensive rats.</p>","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":"897-908"},"PeriodicalIF":2.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144591470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ketogenic Diet for Epilepsy: The Olive Oil Effect to Optimization. A Narrative Review.","authors":"Sofia Zouganeli, Mary Yannakoulia, Achilleas Attilakos, Smaragdi Fessatou, Evdokia K Mitsou, Adamantini Kyriacou, Argirios Dinopoulos","doi":"10.1089/jmf.2025.0009","DOIUrl":"10.1089/jmf.2025.0009","url":null,"abstract":"<p><p>The ketogenic diet (KD) has long been used in the treatment of drug-resistant epilepsy, demonstrating significant beneficial health effects. Various modifications of the KD have been introduced as alternatives to the classical, more restrictive form, aiming to improve patient's adherence while maintaining therapeutic efficacy. Among these adaptations, the Mediterranean ketogenic diet (MedKD) has been primarily implemented in populations in the Mediterranean region. The MedKD integrates elements of the traditional Mediterranean diet, with olive oil as the primary fat source, leveraging its unique properties. This narrative review examines the possible connections between olive oil and the mechanisms of KD, proposing the extra virgin olive oil-rich MedKD as a healthier option with the potential for reduced adverse effects.</p>","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":"833-841"},"PeriodicalIF":2.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144553783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Safety Pharmacological Assessment of Oral Theophylline Administration on Respiratory Function in Sprague-Dawley Rats.","authors":"Sung-Hyun Cho, Minseo Cho, Caglar Doguer, Miae Doo, Jung-Heun Ha","doi":"10.1089/jmf.2025.k.0007","DOIUrl":"10.1089/jmf.2025.k.0007","url":null,"abstract":"<p><p>In this study, we evaluated the safety pharmacological effects and potential adverse reactions of orally administered theophylline. Theophylline, a commonly used bronchodilator, is a xanthine derivative that exerts stimulatory effects on the central nervous system. Using an experimental rat model, we explored the impact of theophylline on respiratory parameters, including respiratory rate, tidal volume, and minute volume. Thirty-two 6-week-old male Sprague-Dawley rats were randomly divided into control and experimental groups. The experimental group received a single oral dose of 100 mg/kg theophylline. Respiratory parameters were measured at baseline (0 h) and at 0.5, 1, 2, 4, and 6 h post oral administration of theophylline using a whole-body plethysmograph. Oral theophylline administration significantly increased the respiratory rate and minute volume at all postdose time points compared with those in the control group, and peak values were observed at 0.5 h postadministration (<i>P</i> < .05). In contrast, the tidal volume remained consistent across all time points, indicating that theophylline enhances respiratory efficiency primarily by increasing the frequency of breaths rather than by altering their depth. Our study demonstrated the ability of theophylline to enhance respiratory efficiency via increased breathing frequency without affecting tidal volume, thus offering insights into the clinical significance of oral theophylline in managing chronic respiratory diseases.</p>","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":"947-953"},"PeriodicalIF":2.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143968035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gly-Pro-Val-Gly-Pro-Ser Low Molecular Weight Fish Collagen Peptide Promotes Hair Regeneration in Human Dermal Papilla Cells and C57BL/6 Mice.","authors":"Jamyeong Koo, Chaerin Lee, Jinhak Kim, Yuri Gwon, Wonchul Lim, Tae-Gyu Lim","doi":"10.1177/1096620X251372008","DOIUrl":"https://doi.org/10.1177/1096620X251372008","url":null,"abstract":"<p><p>Hair loss is characterized by reduced hair thickness, decreased density, and delayed growth and is associated with factors such as aging, stress, and environmental influences. This study investigated the effects of Gly-Pro-Val-Gly-Pro-Ser low molecular weight fish collagen peptide (FC) on improving hair health and alleviating hair loss. Human dermal papilla cells and C57BL/6 mice were used as experimental models. Mice were administered FC at doses of 200, 400, and 800 mg/kg body weight, followed by protein and RNA analyses and histological evaluations. The results showed that FC significantly increased the expression of vascular endothelial growth factor, PCNA, Hepatocyte growth factor, endothelial growth factor, and insulin-like growth factor 1, which play essential roles in hair follicle growth and regeneration. Additionally, FC administration reduced the expression of specific proteins negatively associated with hair health. Histological and morphological analyses revealed that FC enhanced hair follicle size, density, and overall hair quality. These findings suggest that FC may promote hair growth and regeneration.</p>","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144957641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Combination of <i>Citrus Aurantifolia</i> Fruit Rind and <i>Theobroma cacao</i> Seed Extracts Ameliorates Obesity in High-Fat Diet-Fed Rats via the AMPK Pathway.","authors":"SukJin Kim, Sreenath Kundimi, Thirupathi Rao, Sudipta Veeramachaneni, Guru Ramanathan, Yean Kyoung Koo","doi":"10.1177/1096620X251368271","DOIUrl":"https://doi.org/10.1177/1096620X251368271","url":null,"abstract":"<p><p>In the present study, we investigated the anti-obesity effects of LN19183, a combination of extracts of <i>Citrus aurantifolia</i> fruit rind and <i>Theobroma cacao</i> seed, <i>in vitro</i> and <i>in vivo</i>. Oil Red O staining and Western blotting were performed on 3T3-L1 adipocytes to examine the inhibitory effects on lipid accumulation and the underlying mechanisms. Additionally, LN19183, along with a high-fat diet, was administered to rats for 28 days, and body weight and serum biochemical profiles were assessed. <i>In vitro</i> study results showed that LN19183 significantly reduced lipid accumulation in a dose-dependent manner. Moreover, treatment with LN19183 regulated the expression of markers of adipogenesis (PPAR-γ, C/EBPβ, SREBP-1, FABP4, FAS), lipolysis (ACYL, PPARα, CPT-1), and thermogenesis (PGC-1, UCP-1) by adiponectin, leptin, AMPK, and ACC. In vivo, LN19183 administration significantly reduced body weight, serum triglycerides, leptin, glucose and adipose weight. Our study was the first to reveal the anti-obesity effects of LN19183 through adipogenesis and lipolysis, supporting its potential as a nutraceutical for reducing body fat.</p>","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144957665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antioxidant Properties of Mexican <i>Ganoderma lucidum</i> Extracts in Obese C57BL/6 Mice Fed with a High-Fat and Sugar Diet.","authors":"Zoha Bautista-Montero, María E Meneses, Daniel Martínez-Carrera, Mónica Sánchez-Tapia, Julieta Hernández-Acosta, Nimbe Torres, Myrna Bonilla, Ivan Castillo, Beatriz Petlacalco, Nora Fernández, Alfredo Morales, Wilfrido Martínez, Diana Coutiño-Hernández, Mario Aliphat, Miguel Sánchez, Armando R Tovar, Aleyda Pérez-Herrera","doi":"10.1177/1096620X251370638","DOIUrl":"https://doi.org/10.1177/1096620X251370638","url":null,"abstract":"<p><p>Oxidative stress is a key factor of comorbidities in obesity. A Mexican genotype of the medicinal mushroom <i>Ganoderma lucidum</i> (<i>Gl</i>) contains bioactive compounds showing antioxidant, hypocholesterolemic, anti-inflammatory, anticancer, and prebiotic properties. We assessed the effect of standardized <i>Gl</i>-1 and <i>Gl</i>-2 extracts (1%) consumed by obese C57BL/6 mice fed with a high-fat and sugar diet (HFSD), on weight increase, serum parameters, liver lipid accumulation, and the expression of antioxidant genes (glutathione peroxidase 1, catalase [CAT], superoxide dismutase [SOD] 1, SOD2) and proteins (CAT, SOD2, nuclear factor erythroid 2-related factor 2) in the liver. Fifty-six male C57BL/6 mice were randomized into seven groups involving the control and treatments during 17 weeks, as well as using metformin (Met, 250 mg/kg/day) as a reference drug. Serum lipids and glucose levels decreased in mice groups consuming <i>Gl</i> extracts and metformin, in comparison with the HFSD group, as follows: total cholesterol (-11.8% to -35.7%), triglycerides (-8.3% to -24.8%), low-density lipoprotein cholesterol (-19.6% to -51.6%), and glucose (-3.1% to -25.7%). <i>Gl</i>-1 and <i>Gl</i>-2 extracts showed antioxidant properties and prevented lipid accumulation in the liver. The expression of antioxidant genes and proteins was significantly higher (<i>P</i> < .001) in the mice groups consuming <i>Gl</i> extracts, as compared to the HFSD group. This evidence showed that <i>Gl</i>-1 and <i>Gl</i>-2 extracts prevented oxidative stress in the <i>in vivo</i> model of obesity induced by an HFSD.</p>","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144957676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhanced Oral Bioavailability of Lutein and Zeaxanthin via a Self-Emulsifying Delivery System: A Randomized, Double-Blind Cross-Over Study.","authors":"Byung-Sun Choe, Ambrish C, Priya Mk, Jinhak Kim, Kwang-Soo Baek, Yoo-Kyoung Park","doi":"10.1089/jmf.2025.k.0060","DOIUrl":"10.1089/jmf.2025.k.0060","url":null,"abstract":"<p><p>This study was conducted to evaluate and verify the improved bioavailability, as determined by the plasma concentrations of lutein and zeaxanthin, of the test supplement, XanMax® 2002 plus LuZeAbility™, as compared to the reference supplement, XanMax® 2002. For this purpose, this study was designed as a randomized, double-blind, two-group, two-period cross-over clinical trial research. A total of 24 male subjects participated in the clinical trial. They were randomized 1:1 into group 1 or 2 to consume two types of supplements in two separate periods. This study aimed to propose and demonstrate that the bioavailability and the plasma concentrations of lutein and zeaxanthin in the test supplement were significantly higher (110-132.8%) than in the reference supplement in all consecutive periods, such as 12 to 72 h after intake and at the time of maximum concentration. These results are expected to strengthen macular pigment optical density levels, ultimately providing a safe and effective intervention for comprehensively promoting eye health. Therefore, the findings of this study have significant pharmacokinetic implications and offer valid theoretical and practical insights for both academic research and the industrial development in the supplement market.</p>","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":"824-832"},"PeriodicalIF":2.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144553782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and Safety of <i>Saururus chinensis</i> Extract (LHF618) for Treating Allergic Rhinitis: A Randomized, Double-Blind, Placebo-Controlled, Multicenter Clinical Study.","authors":"Yoonhee Lee, Jae Kyung Lee, Juyeon Park, Nahyeon Kim, Hye-Ryun Kang, Yongbum Kwon","doi":"10.1089/jmf.2025.k.0008","DOIUrl":"10.1089/jmf.2025.k.0008","url":null,"abstract":"<p><p>Allergic rhinitis (AR) has become a global health concern due to its increasing prevalence, significantly impacting the quality of life. Traditional treatment options often provide only temporary symptom relief and may cause adverse effects, leading to the exploration of alternative therapies. This study evaluates the effectiveness and safety of standardized <i>Saururus chinensis</i> extract (LHF618) for alleviating symptoms of AR. Over a 4-week period, patients receiving LHF618 showed significant reductions in total nasal symptom scores, particularly for symptoms such as nasal itching, sneezing, and congestion, compared with the control group. Additionally, LHF618 led to a marked improvement in rhinitis control assessment test scores and a significant reduction in specific immunoglobulin E levels related to dust mite allergens. Importantly, no significant adverse effects were observed, indicating that LHF618 is a well-tolerated and safe option. These findings suggest LHF618 could be a promising natural alternative for managing AR, especially in cases related to dust mite allergies.</p>","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":"802-811"},"PeriodicalIF":2.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144225733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}