{"title":"Structure-Guided Preference Feeding Behavioral Responses of Coumarin Analogs in <i>Caenorhabditis elegans</i>.","authors":"Aaron Taehwan Kim, Yeonhwa Park","doi":"10.1177/1096620X261416760","DOIUrl":"10.1177/1096620X261416760","url":null,"abstract":"<p><p>Coumarins are a group of naturally occurring phytochemicals found in various plants with many bioactivities. Recently, it was reported that esculetin (6,7-dihydroxycoumarin) reduced food preference behavior of <i>Caenorhabditis elegans</i> dependent on the human µ-opioid receptor (MOPR). Thus, this study investigated the structure-activity relationships (SAR) of 17 coumarin analogs using a food preference assay in <i>C. elegans</i>. While the parent compound, coumarin, and single substitutions at C3, C5, C7, or C8 had no effect, modifications at C4 and C6 were critical for modulating this behavior. Specifically, 4-hydroxycoumarin, 4-methylcoumarin, 6-hydroxycoumarin, 4-hydroxy-6-methylcoumarin, 6,7-dihydroxycoumarin (esculetin), 7-hydroxy-6-methoxycoumarin (scopoletin), and several di-substituted derivatives significantly reduced the preference index, which was abolished in <i>npr-17</i> (opioid receptor homolog) knockout strains. Additional determination of preference behaviors was conducted with a strain carrying the human MOPR, which showed results comparable to the wildtype, except for 4-hydroxy-6-methylcoumarin and scopoletin. This work demonstrates the potential antagonistic effects of selected coumarins and the utility of <i>C. elegans</i> as an <i>in vivo</i> model for SAR studies targeting human MOPR.</p>","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":"485-488"},"PeriodicalIF":1.8,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146040951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A Review on <i>In Silico</i> Evaluation of Flavonoids as Potential Pharmaceutical Ingredients.","authors":"Sinan Simsek, Emel Akyol, Ilknur Kucuk","doi":"10.1177/1096620X261430296","DOIUrl":"10.1177/1096620X261430296","url":null,"abstract":"<p><p>Flavonoids have antioxidant, antibacterial, and anti-inflammatory properties and are promising candidates for therapeutic and health-promoting applications. The effects of bioactive compounds on health are contingent upon their ingestion and bioavailability. The impact of flavonoids on humans and their potential as food supplements can often be predicted using <i>in silico</i> ADMET (absorption, distribution, metabolism, excretion, and toxicity) modeling. The aim of this review is to examine the drug-like properties of flavonoids using SwissADME and evaluate their pharmaceutical potential as supplements. In the future, flavonoids are expected to find wider use not only as food preservatives or colorants but also as functional food ingredients and nutraceutical supplements. Trends in personalized nutrition, healthy aging, and strategies for chronic disease prevention will particularly enhance the value of flavonoids. However, for this potential to be realized, clarification of regulations, strengthening of toxicological data, and intensifying collaboration between industry and academia are crucial.</p>","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":"517-530"},"PeriodicalIF":1.8,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147444135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Chaimae Alla, Anca Lucau-Danila, Afaf Mehiou, Zachee L E Akissi, Jean-Louis Hilbert, Abdelkhaleq Legssyer, Sevser Sahpaz, Abderrahim Ziyyat
{"title":"Nutrigenomic Insights and Cardiovascular Benefits of Jujube Tree (<i>Ziziphus lotus</i> L.).","authors":"Chaimae Alla, Anca Lucau-Danila, Afaf Mehiou, Zachee L E Akissi, Jean-Louis Hilbert, Abdelkhaleq Legssyer, Sevser Sahpaz, Abderrahim Ziyyat","doi":"10.1177/1096620X261427698","DOIUrl":"10.1177/1096620X261427698","url":null,"abstract":"<p><p><i>Ziziphus lotus</i> has traditionally been used as a phytotherapeutic agent for cardiovascular, metabolic, immune, nervous, and reproductive health. In this study, a multidisciplinary approach combining <i>in vivo</i> nutrigenomic analyses, cardiovascular physiology experiments, and phytochemical and ethnobotanical data was employed to investigate the effects of aqueous <i>Z. lotus</i> extract (ZLex). ZLex significantly upregulated genes involved in nitric oxide synthesis (<i>Camk1</i>, <i>Gch1</i>), smooth muscle relaxation, and angiotensin degradation, correlating with reductions in systolic, diastolic, and mean arterial blood pressure. In addition, ZLex modulated key neurotransmission-related genes (<i>Dbh</i>, <i>Htr2a</i>, <i>Gabrg3</i>), supporting its potential anxiolytic and neuroprotective actions. Immune modulation was indicated by the upregulation of genes associated with anti-inflammatory and antimicrobial responses. Metabolic benefits were linked to the regulation of genes involved in glucose and lipid metabolism, mitochondrial function, and body weight control. Positive effects on reproductive health were suggested by the induction of genes implicated in spermatogenesis. These effects are likely mediated by bioactive constituents such as rutin, kaempferol-3-O-rutinoside, 3',5'-di-C-β-glucopyranosylphloretin, a quercetin dirhamnosyl-galactoside, and myricetin-3-O-rutinoside. Altogether, the findings provide mechanistic support for the traditional use of <i>Z. lotus</i> and highlight its therapeutic potential in managing hypertension and other chronic disorders, including diabetes, obesity, and anxiety.</p>","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":"502-516"},"PeriodicalIF":1.8,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147355657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lizbeth Anahí Portillo-Torres, Aurea Bernardino-Nicanor, Carlos Alberto Gómez-Aldapa, Leopoldo Gonzalez-Cruz, Esmeralda Rangel-Vargas, Ma Refugio Torres-Vitela, Javier Castro-Rosas
{"title":"Inhibitory Effects of Hibiscus Acid on Foodborne Bacteria: A Comprehensive Analysis of the Viability, Motility, and Membrane Disruption of Enterohemorrhagic <i>Escherichia coli</i>, <i>Salmonella</i> Typhimurium, and <i>Listeria monocytogenes</i>.","authors":"Lizbeth Anahí Portillo-Torres, Aurea Bernardino-Nicanor, Carlos Alberto Gómez-Aldapa, Leopoldo Gonzalez-Cruz, Esmeralda Rangel-Vargas, Ma Refugio Torres-Vitela, Javier Castro-Rosas","doi":"10.1177/1096620X251403975","DOIUrl":"10.1177/1096620X251403975","url":null,"abstract":"<p><p>Hibiscus acid has antimicrobial activity against pathogenic bacteria; however, the mechanism of action against these bacteria has not been completely identified. The effect of hibiscus acid on the viability, motility, and cell membrane of multidrug-resistant enterohemorrhagic <i>Escherichia coli</i>, <i>Salmonella</i> Typhimurium, and <i>Listeria monocytogenes</i> was determined. Cell viability was determined by the pour plate technique, and motility was determined by phase contrast microscopy. Acridine orange/ethidium bromide fluorescent staining was performed using a fluorescence microscope to observe live and dead cells. Bacterial cell damage was analyzed by scanning electron microscopy. Finally, nucleotide leakage (DNA and RNA) was evaluated by measuring absorbance at 260 nm using a UV-VIS spectrophotometer. Hibiscus acid treatments (minimum inhibitory concentration [MIC], minimum bactericidal concentration [MBC], 10× minimum inhibitory concentration [10× MIC]) significantly decreased the viable cell counts of the three pathogenic bacterial strains in a time-dependent manner. Hibiscus acid at concentrations of MIC, MBC, and 10× MIC inhibited the motility of bacteria and caused lysis of the bacterial cell membrane. The damage to the membrane was greater as the concentration of hibiscus acid increased. High red fluorescence was found in the cells treated with hibiscus acid at the MIC and 10× MIC, and the release of intracellular material was observed after 2 h of treatment with the three pathogenic bacteria studied. The antimicrobial effect of hibiscus acid was due to the alteration of the membrane permeability of the three pathogenic bacteria studied. Hibiscus acid may represent an alternative to antibiotics for the treatment or prevention of infectious bacterial diseases.</p>","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":"459-470"},"PeriodicalIF":1.8,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145743079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Marcela A B Fagiani, Ana P M Andrade, Anna C P Pereira, Arthur S Zulli, Bianca M E Estopa, Breno L G Rosa, Fabíola A Mello, Gracielle V Gonçalves, Isabella B Ferreira, Liliane G Pereira, Sandra C Genaro, Cecília L Santarém, Sabrina A Lenquiste
{"title":"Tea from Pods with Seeds of <i>Libidibia ferrea</i> (Jucá) Does Not Attenuate Inflammatory Reaction of Acute Colitis in Rats.","authors":"Marcela A B Fagiani, Ana P M Andrade, Anna C P Pereira, Arthur S Zulli, Bianca M E Estopa, Breno L G Rosa, Fabíola A Mello, Gracielle V Gonçalves, Isabella B Ferreira, Liliane G Pereira, Sandra C Genaro, Cecília L Santarém, Sabrina A Lenquiste","doi":"10.1177/1096620X251385497","DOIUrl":"10.1177/1096620X251385497","url":null,"abstract":"<p><p>This study aimed to evaluate the effects of Jucá tea for curative treatment in rats with acute colitis. A total of 40 male <i>Wistar</i> rats (<i>n</i> = 10 per group) were fed a commercial ration and filtered water, wherein one group received Jucá tea by gavage. The rats were divided into the following groups: control, colitis control, drug control receiving sulfasalazine, and Jucá group, where the rats received an intermediate dose of the fruit (285 mg/kg/day). The disease activity index, macroscopic damage score of the large intestine (LI), histopathological analysis of the LI, biochemical examinations, and antioxidant measurements were performed. The group that received Jucá tea exhibited reduced water and feed consumption (<i>P</i> = .000) and presented a higher index of disease activity on days 1 (<i>P</i> = .000) and 7 (<i>P</i> = .004). Additionally, this group presented more severe intestinal lesions on histopathological evaluation of the total damage score (<i>P</i> = .017). The intestinal crypts were not negatively affected by tea consumption (<i>P</i> = .001). Jucá did not cause hepatic alterations in rats, as verified by alanine aminotransferase measurement (<i>P</i> = .04), but lowered albumin levels (<i>P</i> = .00). Jucá tea alters the dietary consumption in animals, is implicated in intestinal damage, and does not soften the inflammatory process caused by colitis. Jucá does not induce hepatotoxicity.</p>","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":"395-406"},"PeriodicalIF":2.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145251562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Maria Magdalena Coman, Benedetta Torbidoni-Baldassari, Lucia Occhigrossi, Giovanni Deiana, Stefania Silvi, Maria Cristina Verdenelli, Valerio Napolioni
{"title":"Probiotic Supplementation in Aged Human Subjects Counteracts Leukocyte Telomere Attrition Rate.","authors":"Maria Magdalena Coman, Benedetta Torbidoni-Baldassari, Lucia Occhigrossi, Giovanni Deiana, Stefania Silvi, Maria Cristina Verdenelli, Valerio Napolioni","doi":"10.1177/1096620X251400155","DOIUrl":"10.1177/1096620X251400155","url":null,"abstract":"<p><p>Probiotic supplementation is gaining attention for its role in maintaining health and enhancing the quality of life of the elderly. Leukocyte telomere length (LTL) is a biomarker of cellular aging, with shorter LTL associated with cardiovascular morbidity and mortality. This study explored whether probiotics could counteract LTL attrition in an ethnically homogeneous cohort of older adults over a 6-month period. Samples were selected from the PROBIOSENIOR trial, a randomized, double-blind, placebo-controlled study involving 46 participants (≥60 years). Participants were randomized to receive either SYNBIO® probiotics (5 × 10<sup>9</sup> CFU/daily dose) or a placebo for 6 months. Genomic DNA was extracted from blood samples at baseline, and 6 months later, LTL measures were obtained via quantitative PCR. A general linear model assessed the \"treatment x time\" interaction as the main outcome. LTL was successfully assessed for all participants (<i>N</i> = 46 × 2 time points). Statistical analysis revealed a significant \"treatment x time\" interaction (<i>P</i> = .034), indicating a reduced LTL attrition rate in the probiotic group compared with the placebo group. A 6-month supplementation with SYNBIO probiotics significantly reduced LTL attrition in an ethnically homogeneous cohort of elderly adults. These findings suggest that probiotics may serve as a simple and effective intervention to mitigate cellular aging and promote healthy aging.</p>","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":"438-443"},"PeriodicalIF":1.8,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145668542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Soo-Jeung Park, Minhee Lee, Seong-Hoo Park, Hyelim Kim, JiYeon Park, Han Ol Kwon, Jong Han Kim, Jeongmin Lee
{"title":"Red Ginseng Oil Enhances Lipid Metabolism and Liver Function in HepG2 Cells and Hypercholesterolemic Rats.","authors":"Soo-Jeung Park, Minhee Lee, Seong-Hoo Park, Hyelim Kim, JiYeon Park, Han Ol Kwon, Jong Han Kim, Jeongmin Lee","doi":"10.1177/1096620X261438295","DOIUrl":"10.1177/1096620X261438295","url":null,"abstract":"<p><p>Hypercholesterolemia is a major risk factor for cardiovascular disease, necessitating the development of effective and safe lipid-lowering interventions. This study evaluated the antihypercholesterolemic effects of KGC11<i>o</i>, a red ginseng oil obtained via supercritical fluid extraction, using both HepG2 cells and a high-fat/high-cholesterol diet-induced hypercholesterolemic rat model. KGC11<i>o</i> treatment significantly improved serum and hepatic lipid profiles, reduced markers of liver injury, and enhanced fecal cholesterol excretion. At the molecular level, KGC11<i>o</i> modulated the expression of key genes involved in cholesterol biosynthesis (3-hydroxy-3-methylglutaryl-CoA reductase), esterification (acyl-CoA:cholesterol acyltransferase), transport (CETP, LPL), and catabolism (LCAT, cholesterol 7α-hydroxylase). Collectively, these findings suggest that KGC11<i>o</i> may serve as a safe, food-derived functional ingredient with potential benefits for the management of hypercholesterolemia and related metabolic disorders. Further studies are warranted to elucidate its molecular mechanisms and to confirm its clinical efficacy.</p>","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":"444-453"},"PeriodicalIF":2.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147690548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Esther E Nwanna, Bukola T Olanrewaju, Idowu S Oyeleye, Opeyemi O Ojueromi, Ganiyu Oboh
{"title":"Functional-Diet Potential of Black Cumin-Enriched Acha-Based Cookies on <i>Plasmodium berghei</i>-Infected Diabetic Mice.","authors":"Esther E Nwanna, Bukola T Olanrewaju, Idowu S Oyeleye, Opeyemi O Ojueromi, Ganiyu Oboh","doi":"10.1177/1096620X251386012","DOIUrl":"10.1177/1096620X251386012","url":null,"abstract":"<p><p>The prevalence of diabetes and malaria remains high in developing countries despite remarkable progress in the health sector. Functional food remedies with acha grains and black cumin have been used locally to treat/manage type 2 diabetes (T2D) and malaria separately. However, this study sought to assess the comorbidity and the ameliorative potential of black cumin-enriched acha-based cookies in <i>Plasmodium berghei</i> infection in diabetic mice. High-fat diet fed mice of 20-25 g were grouped into eight groups (<i>n</i> = 8), while a single dose of streptozotocin (35 mg/kg) was intraperitoneally administered to induce T2D. After this, the NK65 strain of <i>P. berghei</i> was used to infect the mice, and the infected diabetic mice were fed with the formulated cookies for 14 days, and the percentage (%) parasitemia suppression and blood glucose levels were evaluated at 3-day intervals in the morning. The effect of the cookies on pancreatic α-amylase, α-glucosidase, endogenous antioxidant enzymes (superoxide dismutase), catalase, glutathione peroxidase activities, reduced glutathione level, and inflammatory nuclear factor kappa-light-chain-enhancer and interleukin-10 markers was determined. The result of the malaria-infected diabetic mice fed with a fortified cookies diet indicates a reversal of damage incurred compared with the negative control group. This shows that black cumin-enriched acha-based cookies could be a promising nutraceutical therapy in T2D-malaria pathology.</p>","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":"407-417"},"PeriodicalIF":2.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145286427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Edilson Rodrigues Albuquerque, Fernanda de Abreu Braga, Glesie Bertuluci Martins, Ester Pelegrini Silva, Karina Sposito Negrini, Camila Maria Escardille Yoshitani, Arianne Jung Kluck, Lucas Pires Garnier, Gustavo Ratti da Silva, João Tadeu Ribeiro-Paes, Francislaine Aparecida Dos Reis Lívero
{"title":"Exploring the Biomedical Potential of <i>Pereskia grandifolia</i>: A Comprehensive Review of Botanical, Phytochemical, and Pharmacological Aspects.","authors":"Edilson Rodrigues Albuquerque, Fernanda de Abreu Braga, Glesie Bertuluci Martins, Ester Pelegrini Silva, Karina Sposito Negrini, Camila Maria Escardille Yoshitani, Arianne Jung Kluck, Lucas Pires Garnier, Gustavo Ratti da Silva, João Tadeu Ribeiro-Paes, Francislaine Aparecida Dos Reis Lívero","doi":"10.1177/1096620X251389604","DOIUrl":"10.1177/1096620X251389604","url":null,"abstract":"<p><p><i>Pereskia grandifolia</i>, Cactaceae, is a plant native to temperate and tropical regions. Its leaves and fruits are utilized in food and traditional medicine due to their therapeutic and nutritional properties, which have garnered interest in both pharmaceutical and food industries. This review provides an overview of the current biomedical research on <i>P. grandifolia</i>, encompassing botanical and phytochemical aspects, traditional uses, nutritional evidence, <i>in vitro</i> and <i>in vivo</i> preclinical pharmacological studies, and toxicological evaluation. Scientific articles were sourced from databases such as PubMed, Science Direct, SciELO, and Web of Science. Saponins, phenolic compounds, and alkaloids emerge as the main bioactive substances within <i>P. grandifolia</i>. Nutritionally, its leaves and fruits are valued for their high protein and fiber content. In traditional medicine, its leaves are employed to address various ailments, including headache, gastric pain, hemorrhoids, atopic dermatitis, inflammation, hypertension, diabetes, and cancer. <i>In vitro</i> studies on the species have demonstrated antioxidant, cytotoxic, and antimicrobial activity, along with the ability to inhibit the enzyme acetylcholinesterase. <i>In vivo</i> research corroborates its diuretic, antihypertensive, antiobesity, and molluscicidal effects. However, there is limited investigation into its toxicity, and notably, no reports of clinical studies with the species were found. In conclusion, while promising effects of <i>P. grandifolia</i> have been reported, further research is warranted to substantiate its efficacy in folk medicine as an anticancer, antidiabetic, and antihypertensive agent.</p>","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":"428-437"},"PeriodicalIF":2.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145390259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nayane Maria Vieira, Marina Gaiato Monte, Paola da Silva Balin, Dijon Henrique Salomé de Campos, Ronny Peterson Cabral Filho, Anderson Seiji Soares Fujimori, Paulo Eduardo Martins Ribolla, Diego Peres Alonso, Camila Renata Correa, Paula Schmidt Azevedo, Bertha Furlan Polegato, Sergio Alberto Rupp de Paiva, Leonardo Antonio Mamede Zornoff, Katashi Okoshi, Marcos Ferreira Minicucci
{"title":"Influence of Bean Flour (<i>Phaseolus vulgaris</i>) on Cardiac Remodeling after Acute Myocardial Infarction in Rats.","authors":"Nayane Maria Vieira, Marina Gaiato Monte, Paola da Silva Balin, Dijon Henrique Salomé de Campos, Ronny Peterson Cabral Filho, Anderson Seiji Soares Fujimori, Paulo Eduardo Martins Ribolla, Diego Peres Alonso, Camila Renata Correa, Paula Schmidt Azevedo, Bertha Furlan Polegato, Sergio Alberto Rupp de Paiva, Leonardo Antonio Mamede Zornoff, Katashi Okoshi, Marcos Ferreira Minicucci","doi":"10.1177/1096620X251384549","DOIUrl":"10.1177/1096620X251384549","url":null,"abstract":"<p><p>Despite the introduction of new drugs, cardiac remodeling (CR) following myocardial infarction (MI) is still associated with increased mortality. Therefore, the search for new therapeutic strategies and bioactive compounds capable of attenuating CR is highly relevant. Although the underlying mechanisms are not fully understood, growing evidence suggests that oxidative stress regulation and modulation of the intestinal microbiota may contribute to the cardioprotective effects of bean consumption in cardiovascular diseases. We investigated the influence of bean flour on CR and intestinal microbiota after MI. Male Wistar rats underwent experimental infarction or sham surgery and were allocated into (1) Sham fed a standard diet (C = 18); (2) MI fed a standard diet (I = 22); and (3) MI fed a diet with bean flour (IB = 28) 15%. After 3 months were submitted to functional, morphometric, and biochemical study. The average infarct size was 38% for the I group and 40% for the IB group, there being no difference between the groups. The MI groups presented morphological changes and functional variables compared with C. Beans did not attenuate these changes, however, microbiota, the S24-7 Bacteroides, and the Halobacteriaceae firmicutes had reduced abundance after the MI in IB group. The supplementation of bean flour modulates the intestinal microbiota after MI. However, it does not attenuate the CR process following MI.</p>","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":"384-394"},"PeriodicalIF":2.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145286019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}