Journal of medicinal food最新文献_第5页

100% Fruit Juice Intake, Glucose Profile, and Uric Acid: A Systematic Review. 100%果汁摄入、葡萄糖和尿酸：一项系统综述。

IF 2 3区农林科学

Journal of medicinal food Pub Date : 2025-08-01 Epub Date: 2025-06-13 DOI: 10.1089/jmf.2024.0139

Lanfranco D'Elia, Aquilino Flavio Zarrella, Ilaria Libera Pizzulo, Alessia Attanasio, Domenico Rendina, John L Sievenpiper

{"title":"100% Fruit Juice Intake, Glucose Profile, and Uric Acid: A Systematic Review.","authors":"Lanfranco D'Elia, Aquilino Flavio Zarrella, Ilaria Libera Pizzulo, Alessia Attanasio, Domenico Rendina, John L Sievenpiper","doi":"10.1089/jmf.2024.0139","DOIUrl":"10.1089/jmf.2024.0139","url":null,"abstract":"Several studies suggest a favorable effect of 100% fruit juice (100%FJ) on cardio-metabolic risk. However, international dietary guidelines disagree on recommendations regarding fruit drink consumption, and the published European Food Safety Authority draft, based only on epidemiological data, suggested a direct relationship between 100%FJ intake and the development of type 2 diabetes mellitus (T2DM) and gout. Thus, we performed a systematic review of both randomized controlled trials (RCT) and prospective studies that assessed the relationship between 100%FJ intake, uric acid metabolism, and glucose profile. Concerning previous meta-analyses, no new prospective studies were identified for the evaluation of T2DM, and no studies were identified for the assessment of gout risk in the general population; conversely, 3 studies were detected for the assessment of gestational diabetes risk. Moreover, new RCTs were detected and included in an updated meta-analysis on glucose profile and uric acid. 100%FJ intake was associated with a decrease in uric acid, and neutral associations were found for different markers of glucose metabolism and the risk of gestational diabetes. In summary, this meta-analysis confirmed that there was no difference between 100%FJ intake and the comparator on glucose metabolism. It also showed that 100%FJ intake resulted in lower levels of uric acid than the comparator. In addition, the analysis indicated a neutral effect of 100%FJ on gestational diabetes. Finally, the systematic review confirmed the neutral effect of 100%FJ on T2DM and suggested the need for further studies to evaluate the risk of gout.","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":"743-756"},"PeriodicalIF":2.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144289474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Phytochemical Properties of (-)-Epicatechin Promotes Bone Regeneration Inducing Osteogenic Markers Expression BMP2, SPARC, and RUNX2 in Mesenchymal Stem Cells In Vitro. （-）-表儿茶素的植物化学性质促进骨再生，诱导间充质干细胞成骨标志物BMP2、SPARC和RUNX2的体外表达

IF 2 3区农林科学

Journal of medicinal food Pub Date : 2025-08-01 Epub Date: 2025-05-30 DOI: 10.1089/jmf.2024.0256

Icela Palma-Lara, Claudia Camelia Calzada-Mendoza, Elvia Mera-Jiménez, Ernesto Romero López, Juan Luis Amaya-Espinoza, Alberto Parra-Barrera, Gisela Gutiérrez-Iglesias

{"title":"Phytochemical Properties of (-)-Epicatechin Promotes Bone Regeneration Inducing Osteogenic Markers Expression BMP2, SPARC, and RUNX2 in Mesenchymal Stem Cells In Vitro.","authors":"Icela Palma-Lara, Claudia Camelia Calzada-Mendoza, Elvia Mera-Jiménez, Ernesto Romero López, Juan Luis Amaya-Espinoza, Alberto Parra-Barrera, Gisela Gutiérrez-Iglesias","doi":"10.1089/jmf.2024.0256","DOIUrl":"10.1089/jmf.2024.0256","url":null,"abstract":"(-)-Epicatechin (EC), a bioactive compound found in the plant kingdom contained in beans from the cacao tree, and other vegetables, has high flavonoid content. Traditionally consumed as chocolate, presents various benefits in human health. Many flavonoids have demonstrated therapeutic effects against osteoporosis by enhancing bone density; however, the specific impact of EC on bone regeneration remains unknown. Since bone regeneration involves a small group of responsive stem cells, we investigated the flavonoids' effects on key bone precursors like mesenchymal stem cells (MSCs). We used a conventional osteogenic medium alone or combined with different EC concentrations. Our study revealed that low concentrations of EC could enhance the expression of osteogenic genes when combined with low concentrations of osteogenic medium and induced the highest differentiation of human MSCs compared with pharmacological concentrations. So, the increase in the expression of osteoblastic marker genes such as bone morphogenetic protein 2, Runt-related transcription factor 2, and secreted protein acidic and cysteine rich agreed with an increase in cellular calcium deposits. Therefore, we conclude that the natural flavonol (-)-EC improved the expression of genes involved in bone regeneration and could potentially serve as an adjunctive therapy for bone loss diseases.","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":"757-767"},"PeriodicalIF":2.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144183576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Water Extract of Allium Victorialis L. Prevents Doxorubicin-Induced Cardiotoxicity Through Its Antioxidant Property. 大蒜水提物通过抗氧化作用预防阿霉素引起的心脏毒性。

IF 2 3区农林科学

Journal of medicinal food Pub Date : 2025-08-01 Epub Date: 2025-06-24 DOI: 10.1089/jmf.2025.k.0031

Ji-Hye Song, Jangho Lee, Sun-Ho Lee, Jin-Taek Hwang, Min-Sun Kim, JaeEun Myoung, Seunghyun Lee, Hyo-Kyoung Choi

{"title":"Water Extract of Allium Victorialis L. Prevents Doxorubicin-Induced Cardiotoxicity Through Its Antioxidant Property.","authors":"Ji-Hye Song, Jangho Lee, Sun-Ho Lee, Jin-Taek Hwang, Min-Sun Kim, JaeEun Myoung, Seunghyun Lee, Hyo-Kyoung Choi","doi":"10.1089/jmf.2025.k.0031","DOIUrl":"10.1089/jmf.2025.k.0031","url":null,"abstract":"Doxorubicin (DOX), an anthracycline-based anticancer drug, is commonly used to treat various cancers, but its prolonged use may lead to cardiotoxicity. Despite extensive research efforts, effective strategies for managing DOX-induced cardiotoxicity (DICT) remain limited. This study investigated the DICT-inhibitory efficacy of the water extract of Allium victorialis L. (AVE) and its underlying mechanism. AVE protected mouse cardiomyocytes, H9c2 cells, from DOX-induced toxicity while not interfering with DOX's cytotoxic effect on the MDA-MB-231 cells, human breast cancer cells. DOX-induced abnormal heart rate, RR interval, cQT prolongation, and segmentation were normalized following AVE supplementation. Also, AVE reduced the serum levels of creatine kinase and lactate dehydrogenase and suppressed myocardial fibrosis and cell death by DICT in the AVE-fed mice group. Moreover, AVE was shown to restore DOX-induced impaired electrophysiological changes in human-induced pluripotent stem cell-derived cardiomyocytes, including reduced total activity and decreased conduction velocity, while also normalizing the beat period irregularity and beat period mean. A total of 57 metabolites were tentatively identified in the AVE sample. Furthermore, PCR microarray and western blot analyses confirmed that AVE reversibly increased the expression of antioxidant-related genes and proteins. Altogether, the antioxidant properties of AVE could be utilized as a new strategy for preventing and treating DICT.","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":"776-787"},"PeriodicalIF":2.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144475652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficacy and Safety of MT104, A Dietary Supplement Based on Cuscuta Seeds and Heat-Killed Probiotics, on Cognitive Function in Patients with Mild Cognitive Impairment: A 12-Week, Multicenter, Randomized, Double-Blind, Placebo-Controlled Clinical Trial. 基于库库塔籽和热杀益生菌的膳食补充剂MT104对轻度认知障碍患者认知功能的疗效和安全性：一项为期12周、多中心、随机、双盲、安慰剂对照的临床试验

IF 2 3区农林科学

Journal of medicinal food Pub Date : 2025-08-01 Epub Date: 2025-06-25 DOI: 10.1089/jmf.2024.k.0267

Bo-Hyung Kim, Minji Kwon, Sung-Vin Yim, Jin-Woo Park, Chan-Nyoung Lee, Soo-Wan Chae, Jin Gyu Choi, Sang Cheol Park, Mi Won Sohn, Sang Zin Choi, Jin San Lee

{"title":"Efficacy and Safety of MT104, A Dietary Supplement Based on Cuscuta Seeds and Heat-Killed Probiotics, on Cognitive Function in Patients with Mild Cognitive Impairment: A 12-Week, Multicenter, Randomized, Double-Blind, Placebo-Controlled Clinical Trial.","authors":"Bo-Hyung Kim, Minji Kwon, Sung-Vin Yim, Jin-Woo Park, Chan-Nyoung Lee, Soo-Wan Chae, Jin Gyu Choi, Sang Cheol Park, Mi Won Sohn, Sang Zin Choi, Jin San Lee","doi":"10.1089/jmf.2024.k.0267","DOIUrl":"10.1089/jmf.2024.k.0267","url":null,"abstract":"Mild cognitive impairment (MCI) represents the symptomatic predementia stage of Alzheimer's disease (AD). To delay the progression of MCI to AD, appropriate interventions capable of modulating the microbiota-gut-brain (MGB) axis are necessary. This study was designed to assess the efficacy and safety of MT104, a dietary supplement comprising Cuscuta seeds and heat-killed probiotics, based on the biological mechanisms regulating the MGB axis in patients with MCI. This was a multicenter, randomized, double-blind, and placebo-controlled study. All patients were randomly allocated in a 1:1 ratio to the MT104 or placebo group. Global cognition was assessed using the Korean-Montreal Cognitive Assessment (K-MoCA) and Korean-Mini Mental State Examination at baseline and after 12 weeks of treatment. The visuospatial function was assessed using the copying performance from the Rey Complex Figure Test (RCFT), and verbal and visual memory functions were evaluated using the Seoul Verbal Learning Test (SVLT) and RCFT. Differences between groups were analyzed using either the t-test or the Mann-Whitney U test. Analyses of covariance and ranked analysis of covariance were performed. The mean changes in verbal memory function, as measured by the SVLT delayed recall, showed clinically significant improvement in the MT104 group relative to the placebo group in the intention-to-treat and per-protocol groups. Global cognition, as measured using the K-MoCA, also significantly improved in the per-protocol group. In addition, no significant findings were identified. This study highlighted the potential of dietary therapeutic strategies focused on reducing the risk of progression from MCI to AD.","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":"812-823"},"PeriodicalIF":2.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144528397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fridericia chica (Bonpl.) L.G. Lohmann: An Overview of Medicinal Plant Studies. Fridericia china （Bonpl.）L.G. Lohmann：药用植物研究综述。

IF 2 3区农林科学

Journal of medicinal food Pub Date : 2025-08-01 Epub Date: 2025-06-06 DOI: 10.1089/jmf.2023.0286

Vitória Ribeiro Garcia de Figueiredo-Muniz, Ana Paula Biz, Ilza Maria de Oliveira Sousa, Luciana Igarashi Mafra, Mary Ann Foglio, Alvaro Luiz Mathias, Marcos Rogério Mafra

{"title":"Fridericia chica (Bonpl.) L.G. Lohmann: An Overview of Medicinal Plant Studies.","authors":"Vitória Ribeiro Garcia de Figueiredo-Muniz, Ana Paula Biz, Ilza Maria de Oliveira Sousa, Luciana Igarashi Mafra, Mary Ann Foglio, Alvaro Luiz Mathias, Marcos Rogério Mafra","doi":"10.1089/jmf.2023.0286","DOIUrl":"10.1089/jmf.2023.0286","url":null,"abstract":"Fridericia chica (Bonpl.) L.G. Lohmann (synonym Arrabidaea chica Verlot) has aroused the medical interest of researchers in recent years. The leaves of F. chica are used in folk medicine as anti-inflammatory, antimicrobial, for wound healing of skin or mucous membranes, ulcers, intestinal colic, diarrhea, and blood disorders such as hemorrhage and anemia. Herein, we present a review of the scientific production on F. chica employing the SciVerse Scopus database to elucidate the research trends and perspectives in this field of science. To identify relevant publications, 95 research articles and 10 reviews were selected, totaling 105 publications, of which Brazilian researchers published 91. The research areas most covered in the publications were Pharmacology, Agricultural and Biological Sciences, with the keywords highlighting flavonoids chemical class as the most cited. The data collected provides an overview of the status of this species, with scarce research reports on the application of F. chica products. Furthermore, F. chica is also unexplored in Food Science and Technology, demonstrating new research opportunities.","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":"727-742"},"PeriodicalIF":2.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144234367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Therapeutic and Biological Properties of White Garlic and Black Garlic Extracts (Allium sativum L.): A Comparative Analysis. 白蒜和黑蒜提取物的治疗和生物学特性：比较分析。

IF 2 3区农林科学

Journal of medicinal food Pub Date : 2025-08-01 Epub Date: 2025-06-13 DOI: 10.1089/jmf.2023.0229

Halima Ben Hmad, Najet Sellami, Houda Ben Jemaa, Mohamed Montassar Lasram

{"title":"Therapeutic and Biological Properties of White Garlic and Black Garlic Extracts (Allium sativum L.): A Comparative Analysis.","authors":"Halima Ben Hmad, Najet Sellami, Houda Ben Jemaa, Mohamed Montassar Lasram","doi":"10.1089/jmf.2023.0229","DOIUrl":"10.1089/jmf.2023.0229","url":null,"abstract":"Black garlic is a rich natural source of beneficial compounds and exhibits various biological activities. This study aimed to quantify flavonoids and polyphenols in white garlic and black garlic extracts, evaluate their antioxidant power, assess their antibacterial activity against specific pathogenic bacteria, and examine their antiproliferative effects on U87 glioblastoma cancer cells. The extraction was conducted using distilled water, methanol, and ethanol, and the quantification of bioactive compounds, antioxidant activity using the 2,2-diphenyl-1-picrylhydrazyl test, antibacterial activity, and antiproliferative activity using the MTT assay. The findings of this research showed significantly higher levels of phenolic acids and flavonoids in black garlic compared to raw garlic, with methanol extracts containing the highest concentration of flavonoids (2.33 mg quercetin equivalent/g DM) and polyphenols (63.25 mg ascorbic acid equivalent/g DM). Both white garlic and black garlic extracts displayed excellent antioxidant activity, while methanol extracts of black garlic exhibited the highest inhibition percentages (96.3% ± 0.36). Methanol extracts of black garlic also demonstrated effective antibacterial activity, while the antiproliferative effects were significant for all extracts on U87 glioblastoma cancer cells. These findings highlight black garlic as a promising source of compounds with antiproliferative, antibacterial, and antioxidant properties, although the concentration of bioactive compounds may vary among different extracts.","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":"768-775"},"PeriodicalIF":2.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144289477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of Locusta migratoria Hydrolysate on Metabolic Dysfunction-Associated Steatotic Liver Disease in Mice. 枇杷水解液对小鼠代谢功能障碍相关脂肪变性肝病的影响。

IF 2 3区农林科学

Journal of medicinal food Pub Date : 2025-08-01 Epub Date: 2025-06-30 DOI: 10.1089/jmf.2025.k.0003

Jiaxiang Zheng, Sunyoon Jung, Jung-Heun Ha, Yoonhwa Jeong

{"title":"Effects of Locusta migratoria Hydrolysate on Metabolic Dysfunction-Associated Steatotic Liver Disease in Mice.","authors":"Jiaxiang Zheng, Sunyoon Jung, Jung-Heun Ha, Yoonhwa Jeong","doi":"10.1089/jmf.2025.k.0003","DOIUrl":"10.1089/jmf.2025.k.0003","url":null,"abstract":"Locusta migratoria (LM) is an edible insect recognized as a valuable source of high-quality proteins, essential amino acids, vitamins, and minerals. Metabolic dysfunction-associated steatotic liver disease (MASLD) is often associated with metabolic syndrome (MetS) and is characterized by excessive fat accumulation in the liver along with low-grade chronic inflammation. In addition, chronic metabolic dysfunction and hepatic lipid toxicity can induce acute liver injury (ALI). This study investigated the protective effects of LM hydrolysate against MASLD and the related liver pathophysiology. Mice were fed a high-fat, high-fructose, and high-cholesterol diet to induce MASLD, whereas ALI was induced using lipopolysaccharide (LPS) and d-galactosamine (Gal). LM hydrolysate reduced liver weight by decreasing hepatic ectopic fat accumulation and downregulating lipogenic gene expression in the liver. In addition, LM hydrolysate improved dyslipidemia by lowering the serum triglyceride and low-density lipoprotein cholesterol levels. LM hydrolysate also demonstrated hepatoprotective properties by reducing the protein levels of tumor necrosis factor-alpha and interleukin-6 while enhancing antioxidant capacity, thereby mitigating liver damage induced by LPS/Gal under MASLD-promoting conditions. Thus, LM hydrolysate significantly attenuated the pathological changes in the hepatic tissue. These findings suggest that LM hydrolysate has potential as a functional food or dietary supplement for managing MetS-related disorders and protecting against liver pathology.","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":"788-801"},"PeriodicalIF":2.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144528396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Curative Effects of Vitamins D3&K2 on the Expressions of p53, Bax, Bcl-2, and Oxidative Stress Induced by Methotrexate in ZFL Epithelial Cells. 维生素d3和k2对甲氨蝶呤诱导ZFL上皮细胞p53、Bax、Bcl-2表达及氧化应激的影响

IF 1.7 3区农林科学

Journal of medicinal food Pub Date : 2025-07-01 Epub Date: 2025-04-24 DOI: 10.1089/jmf.2024.0261

Güllü Kaymak

{"title":"The Curative Effects of Vitamins D3&K2 on the Expressions of p53, Bax, Bcl-2, and Oxidative Stress Induced by Methotrexate in ZFL Epithelial Cells.","authors":"Güllü Kaymak","doi":"10.1089/jmf.2024.0261","DOIUrl":"10.1089/jmf.2024.0261","url":null,"abstract":"Methotrexate (MTX), a folate antimetabolite, is a cytotoxic drug known to cause cytotoxicity associated with free oxygen radicals. This study investigated the effect of vitamins D3 and K2 on MTX-induced liver cell injury using the zebrafish liver cell line (CRL-2643). Observed effects, levels of antioxidant enzymes, lipid peroxidation marker, and total antioxidant/oxidant status were evaluated by spectrophotometric methods. The mRNA expressions of p53, Bax, and Bcl-2 were measured using RT-PCR. In addition, acridine orange/ethidium bromide staining was performed to analyze the apoptosis status of the cells. The IC50 value of MTX at 48 h was calculated as 442 µg/mL with an MTT assay. The doses of D3&K2 are determined based on the recommended dose to be taken daily. As a result, this study suggests that MTX treatment induced oxidative damage on the liver cell, as assessed by increased reactive oxygen levels, lipid peroxidation, and decreased glutathione levels. In addition, while MTX increased the expression of the p53 and proapoptotic marker Bax, it decreased the expression of the anti-apoptotic factor Bcl-2. In conclusion, D3&K2 treatment protects against MTX-induced liver cell toxicity. It is thought that they can be used as a potential agent in clinical applications with MTX in treatment.","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":"657-667"},"PeriodicalIF":1.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144030311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction to: Indian Gooseberry and Barley Sprout Complex Prevent Oxidative Stress and Photoaging of the Skin in Ultraviolet B-Irradiated SHK-I Mice by Lee et al. Journal of Medicinal Food 2024;27(6):488-501; doi: 10.1089/jmf.2023.K.0229. 更正：印度猕猴桃和大麦芽复合物防止紫外线b照射的SHK-I小鼠皮肤的氧化应激和光老化。药膳学报；2024;27(6):488-501；doi: 10.1089 / jmf.2023.K.0229。

IF 1.7 3区农林科学

Journal of medicinal food Pub Date : 2025-07-01 Epub Date: 2025-04-23 DOI: 10.1089/jmf.2023.K.0229.correx

引用次数: 0

Functional Observation Battery Test for Single Intravenous Caffeine Exposure in Male ICR Mice. 雄性ICR小鼠单次静脉咖啡因暴露的功能观察电池试验。

IF 1.7 3区农林科学

Journal of medicinal food Pub Date : 2025-07-01 Epub Date: 2025-04-03 DOI: 10.1089/jmf.2024.k.0289

Sung-Hyun Cho, Yeon-Woo Kim, Miae Doo, Jung-Heun Ha

{"title":"Functional Observation Battery Test for Single Intravenous Caffeine Exposure in Male ICR Mice.","authors":"Sung-Hyun Cho, Yeon-Woo Kim, Miae Doo, Jung-Heun Ha","doi":"10.1089/jmf.2024.k.0289","DOIUrl":"10.1089/jmf.2024.k.0289","url":null,"abstract":"This study investigated the behavioral responses of male Institute for Cancer Research (ICR) mice to intravenous caffeine exposure via a functional observation battery (FOB) test. Thirty-two experimental mice were randomly assigned to four groups (n = 8 per group) and received intravenous caffeine at a dose of 0, 5, 10, or 20 mg/kg. Functional behaviors were observed at 0, 0.25, 1.5, 6, and 24 h after intravenous caffeine administration. Among the hand-held observations, the ease of removal from the cage and the ease of handling were significantly altered in all caffeine-exposed mice in both a dose-dependent and a time-dependent manner. In terms of physiological responses, both stimulus responses and locomotor activities were significantly affected by intravenous caffeine exposure. Specifically, the tail pinch response was significantly impaired in half of the mice in the 10 mg/kg and 20 mg/kg groups. Moreover, the rearing count decreased in the 10 mg/kg group at 1.5 to 6 h and in the 20 mg/kg group at 1.5 h after intravenous caffeine exposure. Furthermore, locomotor activity was markedly increased 0.25 h after intravenous caffeine administration in the 20 mg/kg group. These findings clearly indicate that intravenous caffeine exposure significantly impacts functional behaviors, as assessed by an FOB test, which is consistent with widely accepted safety pharmacology testing guidelines.","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":"719-724"},"PeriodicalIF":1.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143780257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0