Journal of medicinal food最新文献_第7页

Lutein-Zeaxanthin Extract (XanMax^® 2002) Attenuates Oxidative Stress, Neuroinflammation, and Memory Deficits in H₂O₂-Exposed Neuro-2a Cells and Scopolamine-Induced Mice. 叶黄素-玉米黄素提取物（XanMax®2002）减轻h2o2暴露的神经2a细胞和东莨菪碱诱导小鼠的氧化应激、神经炎症和记忆缺陷。

IF 1.8 3区农林科学

Journal of medicinal food Pub Date : 2026-05-01 Epub Date: 2026-03-30 DOI: 10.1177/1096620X261430176

Yeonhwa Lee, Hyelim Kim, Jinhee Kim, Jeongjin Park, Yuri Gwon, Jinhak Kim, Priya Mk, Woojin Jun

{"title":"Lutein-Zeaxanthin Extract (XanMax® 2002) Attenuates Oxidative Stress, Neuroinflammation, and Memory Deficits in H2O2-Exposed Neuro-2a Cells and Scopolamine-Induced Mice.","authors":"Yeonhwa Lee, Hyelim Kim, Jinhee Kim, Jeongjin Park, Yuri Gwon, Jinhak Kim, Priya Mk, Woojin Jun","doi":"10.1177/1096620X261430176","DOIUrl":"10.1177/1096620X261430176","url":null,"abstract":"Age-related cognitive impairment is often linked to cholinergic dysfunction and increased oxidative stress. This study explored the neuroprotective potential of lutein-zeaxanthin extract (XanMax® 2002; LZ) through both in vitro and in vivo approaches. In vitro, Neuro-2a cells exposed to hydrogen peroxide (H2O2) were treated with LZ (5-20 μg/mL), leading to decreased expression of apoptosis-related proteins. In vivo, memory impairment was induced by scopolamine in C57BL/6N mice, followed by oral administration of LZ (4 or 8 mg/kg) for 4 weeks. Behavioral assessments-including the Morris water maze, Y-maze, and passive avoidance tests-demonstrated significant improvements in spatial learning, working memory, and memory retention in LZ-treated groups, particularly at the higher dose. Biochemical analysis revealed increased acetylcholine levels, reduced acetylcholinesterase activity, and downregulation of oxidative stress and neuroinflammatory markers in brain tissue. Moreover, LZ supplementation upregulated genes associated with synaptic function and memory. The cognitive-enhancing effects of LZ were comparable with those of donepezil. These findings suggest that LZ may exert neuroprotective effects through antioxidant and anti-inflammatory mechanisms and are a potential dietary intervention for cognitive decline.","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":"268-278"},"PeriodicalIF":1.8,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147574355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neohesperidin from Aurantii Fructus Immaturus Exerts Antidepressant-Like Effects and Modulates Glucocorticoid Receptor Signaling in a Chronic Stress Model. 枳实新橙皮苷在慢性应激模型中发挥抗抑郁样作用并调节糖皮质激素受体信号传导。

IF 1.8 3区农林科学

Journal of medicinal food Pub Date : 2026-05-01 Epub Date: 2026-03-19 DOI: 10.1177/1096620X261434812

Eunho Chun, Soojung Yoon, Hamid Iqbal, Sun Yeou Kim, Seon Hee Kim, Jeong June Choi, Mirim Jin

{"title":"Neohesperidin from Aurantii Fructus Immaturus Exerts Antidepressant-Like Effects and Modulates Glucocorticoid Receptor Signaling in a Chronic Stress Model.","authors":"Eunho Chun, Soojung Yoon, Hamid Iqbal, Sun Yeou Kim, Seon Hee Kim, Jeong June Choi, Mirim Jin","doi":"10.1177/1096620X261434812","DOIUrl":"10.1177/1096620X261434812","url":null,"abstract":"Depression, a mood disorder characterized by persistent negative emotions and impaired functioning, is associated with dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis and glucocorticoid receptor (GR) dysfunction. Aurantii Fructus Immaturus (AFI), the immature fruit of Citrus aurantium Linné, has been used in East Asian herbal medicine, and neohesperidin (NHD), a principal constituent of AFI, has been studied for its antidepressant properties. This study aimed to elucidate the mechanisms underlying the antidepressant effects of NHD, focusing on its ability to enhance GR expression and activity, thereby normalizing HPA axis function and mitigating neuroinflammation. AFI extract and its component NHD ameliorated depression-like behaviors in chronic restraint stress mice with normalized plasma corticosterone (CORT) levels. Moreover, NHD treatment reduced hippocampal expression of proinflammatory cytokine genes (TNFA, IL6, IL1A, and IL1B) while enhancing GR expression, particularly the NR3C1 exon 17 and 110 variants homologous to human GR variants implicated in depression. In cultured cells, NHD not only reversed CORT-induced neurite atrophy in N2a cells but also suppressed lipopolysaccharide-induced cytokine release in BV2 microglia. Notably, gene silencing of the GR via siRNA abrogated these neuritogenic and antineuroinflammatory effects, demonstrating that NHD exerts its antidepressant and neuroinflammation-suppressive actions in a GR-dependent manner. These findings suggest a promising therapeutic potential for AFI and NHD in stress-related depressive disorders, offering a multi-target approach that addresses both stress response and neuroinflammation through modulation of GR expression.","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":"257-267"},"PeriodicalIF":1.8,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147486357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cinnamyl Alcohol Attenuates Osteoarthritis Progression via PIGR-Mediated Regulation of Chondrocyte Senescence and Cartilage Homeostasis. 肉桂醇通过pigr介导的软骨细胞衰老和软骨稳态调节减缓骨关节炎的进展。

IF 1.8 3区农林科学

Journal of medicinal food Pub Date : 2026-05-01 Epub Date: 2026-04-17 DOI: 10.1177/1096620X261430173

Qi Zhu, Qingxia You, Jiaojiao Deng, Hongting Tang, Yuhan Hu, Yuanmeng Liao, Ying Miao

{"title":"Cinnamyl Alcohol Attenuates Osteoarthritis Progression via PIGR-Mediated Regulation of Chondrocyte Senescence and Cartilage Homeostasis.","authors":"Qi Zhu, Qingxia You, Jiaojiao Deng, Hongting Tang, Yuhan Hu, Yuanmeng Liao, Ying Miao","doi":"10.1177/1096620X261430173","DOIUrl":"10.1177/1096620X261430173","url":null,"abstract":"Osteoarthritis (OA) is characterized by inflammation-driven chondrocyte senescence and extracellular-matrix degradation. However, the molecular mechanisms linking inflammatory stress to chondrocyte aging remain poorly understood. Here, we identify cinnamyl alcohol (CA) as a natural small-molecule compound that attenuates OA progression through polymeric immunoglobulin receptor (PIGR)-mediated signaling in vitro. CA reduced inflammatory cytokine production, suppressed senescence-associated secretory phenotype gene expression, and preserved cartilage homeostasis in lipopolysaccharide- or interleukin-1β-stimulated chondrocytes. In a destabilization-of-the-medial-meniscus mouse model, intra-articular CA administration markedly alleviated cartilage degeneration and matrix loss. Integrating network pharmacology, molecular docking, and mass-spectrometry-based proteomic profiling, we identified PIGR as a convergent target of CA, validated by limited proteolysis (drug affinity responsive target stability) and loss-of-function assays. PIGR silencing abolished CA's antisenescent and cartilage-protective effects, confirming its essential role. Mechanistically, CA restored PIGR expression to modulate inflammatory signaling and maintain chondrocyte phenotype stability. These findings uncover a previously unrecognized CA-PIGR axis that couples inflammatory stress to cartilage aging and suggest CA as a promising natural therapeutic candidate for OA management.","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":"279-293"},"PeriodicalIF":1.8,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147717035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preventive Effect of Standardized Lespedeza cuneata Extract on Dexamethasone-Induced Muscle Atrophy in C57BL/6N Mice. 标准胡椒子提取物对地塞米松致C57BL/6N小鼠肌萎缩的预防作用。

IF 1.8 3区农林科学

Journal of medicinal food Pub Date : 2026-05-01 Epub Date: 2026-03-09 DOI: 10.1177/1096620X261428023

Minseong Kang, Eun Jin Kim, Taeuk Kim, Yeeun Kim, Dahye Kang, Changhee Kim, Jae-Kwan Hwang

{"title":"Preventive Effect of Standardized Lespedeza cuneata Extract on Dexamethasone-Induced Muscle Atrophy in C57BL/6N Mice.","authors":"Minseong Kang, Eun Jin Kim, Taeuk Kim, Yeeun Kim, Dahye Kang, Changhee Kim, Jae-Kwan Hwang","doi":"10.1177/1096620X261428023","DOIUrl":"10.1177/1096620X261428023","url":null,"abstract":"Muscle atrophy, characterized by a decline in muscle mass and function, results from an imbalance between protein synthesis and degradation. This study explored the effects of standardized Lespedeza cuneata extract (LCE) on dexamethasone (DEX)-induced muscle atrophy. The mice were orally administered LCE for 17 days. Starting on day 7 of oral administration, DEX was intraperitoneally injected into mice daily for 10 days to induce muscle atrophy. LCE treatment significantly improved grip strength by 22.27% and 33.16% and increased muscle volume by 17.47% and 23.00% at doses of 250 and 500 mg/kg/day, respectively, compared with the DEX group, and also markedly restored hind limb muscle weight. At the molecular level, LCE decreased the mRNA expression of myostatin, muscle ring finger1, and muscle atrophy F-box, which are involved in proteolysis, by inhibiting forkhead box O3a translocation. Furthermore, LCE activated the mammalian target of rapamycin pathway and upregulated myogenesis-related genes via the phosphoinositide 3-kinase/Akt pathway. It also reduced nuclear factor kappa B-mediated inflammatory cytokines, including tumor necrosis factor alpha and interleukin-6. Thus, LCE may serve as a functional food ingredient that prevents muscle atrophy.","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":"247-256"},"PeriodicalIF":1.8,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147390216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hydroxypropyl Methylcellulose as a Functional Dietary Fiber Preserves Intestinal Barrier Integrity via NF-κB Modulation Under Inflammatory Conditions. 羟丙基甲基纤维素作为功能性膳食纤维在炎症条件下通过NF-κB调节保持肠道屏障完整性。

IF 1.8 3区农林科学

Journal of medicinal food Pub Date : 2026-04-01 Epub Date: 2026-03-25 DOI: 10.1177/1096620X261430170

Mingyeong Kim, Chi Heung Cho, Sera Kim, Mi-Jin Oh, Ho-Young Park, In-Wook Choi, Sang-Hoon Lee

{"title":"Hydroxypropyl Methylcellulose as a Functional Dietary Fiber Preserves Intestinal Barrier Integrity via NF-κB Modulation Under Inflammatory Conditions.","authors":"Mingyeong Kim, Chi Heung Cho, Sera Kim, Mi-Jin Oh, Ho-Young Park, In-Wook Choi, Sang-Hoon Lee","doi":"10.1177/1096620X261430170","DOIUrl":"10.1177/1096620X261430170","url":null,"abstract":"Intestinal epithelial barrier integrity is crucial for maintaining gut homeostasis and preventing luminal inflammation. Disruption of tight junctions (TJs) by pro-inflammatory cytokines such as tumor necrosis factor-α and interferon-γ contributes to barrier dysfunction, a hallmark of disorders like inflammatory bowel disease. In this study, we investigated the protective effects of hydroxypropyl methylcellulose (HPMC), a widely used excipient and dietary fiber, against cytokine-induced epithelial barrier dysfunction in Caco-2 cell monolayers. HPMC treatment preserved transepithelial electrical resistance, reduced paracellular leakage of FITC-dextran, and significantly suppressed the secretion of inflammatory mediators, including interleukin (IL)-8, IL-1β, IL-6, and monocyte chemoattractant protein (MCP)-1. Furthermore, HPMC restored the expression and localization of TJ proteins zonula occludens-1 and occludin and attenuated NF-κB activation by inhibiting IκBα phosphorylation and subsequent nuclear translocation. These findings indicate that HPMC counteracts cytokine-driven epithelial barrier disruption through coordinated anti-inflammatory and barrier-stabilizing actions. Collectively, our results demonstrate that noncytotoxic HPMC (12.5-100 μg/mL) has potential as a safe pharmaceutical excipient and functional dietary fiber capable of supporting intestinal health under inflammatory conditions.","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":"222-231"},"PeriodicalIF":1.8,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147512849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Heat-Treated Culture-Dried Lactiplantibacillus plantarum L-14 Regulates Lipid Metabolism and Attenuates Diet-Induced Obesity in Adipose Tissue. 加热培养-干燥植物乳杆菌L-14调节脂肪组织脂质代谢和减轻饮食诱导的肥胖。

IF 1.8 3区农林科学

Journal of medicinal food Pub Date : 2026-04-01 Epub Date: 2026-03-25 DOI: 10.1177/1096620X261434662

Jeongjin Park, Woojin Jun

{"title":"Heat-Treated Culture-Dried Lactiplantibacillus plantarum L-14 Regulates Lipid Metabolism and Attenuates Diet-Induced Obesity in Adipose Tissue.","authors":"Jeongjin Park, Woojin Jun","doi":"10.1177/1096620X261434662","DOIUrl":"10.1177/1096620X261434662","url":null,"abstract":"Obesity is a major global health concern associated with metabolic complications such as insulin resistance, dyslipidemia, and chronic inflammation. Hence, we investigated the effects of heat-treated culture-dried Lactiplantibacillus plantarum L-14 (L14) supplementation on lipid metabolism and obesity-related metabolic dysregulation in a high-fat diet (HFD)-induced mouse model. Male C57BL/6J mice were fed an HFD with or without L14 supplementation for 10 weeks. Throughout this period, body weight, fat mass, and biochemical parameters were evaluated, while adipose tissue was analyzed for histological changes and gene expression related to lipogenesis and lipolysis. L14 supplementation significantly reduced body weight and fat mass without affecting food intake. Serum glucose levels, lipid profiles, and liver function markers were improved in the supplemented groups. Histological and micro-CT analyses showed reduced fat mass and adipocyte size in adipose tissue. At the molecular level, L14 downregulated key lipogenic genes SREBP-1, PPARγ, SCD1, FAS, ACC, and DCAT while upregulating genes AMPK, PGC-1α, PPARα, ATGL, HSL, UCP-1, and CPT-1 involved in lipolysis and fatty acid oxidation. These findings indicate that L14 suppresses lipid synthesis while enhancing lipid breakdown and energy utilization in adipose tissue. L14 effectively mitigated HFD-induced obesity and metabolic dysregulation by modulating lipid metabolism in adipose tissue. These results suggest that L14 has potential as a functional probiotic for the management of obesity and related metabolic disorders.","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":"232-240"},"PeriodicalIF":1.8,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147512811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Low-Molecular-Weight Collagen Peptide Supplementation Improves Cellulite Severity, Skin Elasticity, and Hair Shaft Diameter: A Clinical Study with Pharmacokinetic Evaluation. 补充低分子胶原蛋白肽可改善脂肪团严重程度、皮肤弹性和毛干直径：一项药代动力学评价的临床研究。

IF 1.8 3区农林科学

Journal of medicinal food Pub Date : 2026-04-01 Epub Date: 2026-03-06 DOI: 10.1177/1096620X261428336

Sehee Hwang, Jihyun Won, Suyeon Kim, Wonku Kang, Miyoung Park

{"title":"Low-Molecular-Weight Collagen Peptide Supplementation Improves Cellulite Severity, Skin Elasticity, and Hair Shaft Diameter: A Clinical Study with Pharmacokinetic Evaluation.","authors":"Sehee Hwang, Jihyun Won, Suyeon Kim, Wonku Kang, Miyoung Park","doi":"10.1177/1096620X261428336","DOIUrl":"10.1177/1096620X261428336","url":null,"abstract":"The objective of this study was to evaluate the potential applications of low-molecular-weight collagen peptides (LMWCPs), produced through enzymatic hydrolysis of fish skin-derived gelatin using a specific protease. LMWCP is enriched in Gly-X-Y tripeptide sequences, particularly Gly-Pro-Hyp (GPH). Preliminary human pharmacokinetic data showed that oral LMWCP markedly increased systemic exposure to GPH, yielding an approximately 54-fold higher area under the concentration-time curve from 0 to 2 h (3388 ± 1084 ng·h/mL) than general collagen. In a subsequent randomized, placebo-controlled trial, 114 women aged 20-50 years with thigh cellulite and self-reported hair thinning received either LMWCP (1000 mg/day) or placebo for 24 weeks. Efficacy endpoints included cellulite severity, dermal-subcutaneous border length, skin roughness, skin elasticity, and hair diameter. The LMWCP group demonstrated significant improvements in cellulite severity, dermal-subcutaneous border length, skin roughness, and skin elasticity at weeks 12 and 24 compared to the placebo group. Hair diameter also increased significantly at week 24, with a larger proportion of participants in the LMWCP group exhibiting measurable hair thickening. These findings indicate that LMWCP, characterized by high GPH content and enhanced systemic exposure resulting from targeted enzymatic hydrolysis, exerts beneficial effects on both skin and hair parameters. Daily intake of LMWCP for 24 weeks effectively reduces thigh cellulite and promotes hair thickness, supporting its potential as an orally administered functional ingredient for skin and hair health.","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":"187-195"},"PeriodicalIF":1.8,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147365868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anthocyanin-Containing Rose Petal Extract for Photoaging Improvement: A 12-Week Double-Blind Placebo-Controlled Clinical Trial. 含花青素玫瑰花瓣提取物改善光老化：一项为期12周的双盲安慰剂对照临床试验。

IF 1.8 3区农林科学

Journal of medicinal food Pub Date : 2026-04-01 Epub Date: 2026-03-06 DOI: 10.1177/1096620X261430177

Ha Na Kim, Minhee Park, Kyoungae Won, Yuri Park, Myeonghwan Oh, Jeongrai Lee, Miyeong Lee, Tae-Gyu Lim, Wonchul Lim

{"title":"Anthocyanin-Containing Rose Petal Extract for Photoaging Improvement: A 12-Week Double-Blind Placebo-Controlled Clinical Trial.","authors":"Ha Na Kim, Minhee Park, Kyoungae Won, Yuri Park, Myeonghwan Oh, Jeongrai Lee, Miyeong Lee, Tae-Gyu Lim, Wonchul Lim","doi":"10.1177/1096620X261430177","DOIUrl":"10.1177/1096620X261430177","url":null,"abstract":"Skin photoaging, characterized by wrinkles, loss of elasticity, dryness, and pigmentation, is primarily driven by UV-induced oxidative stress, inflammation, and degradation of extracellular matrix proteins. Polyphenol-rich botanicals, particularly anthocyanin-containing Rosa chinensis Jacq. petals, have shown promising antioxidant and collagen-supportive properties in preclinical studies, yet clinical evidence has been lacking. This randomized, double-blind, placebo-controlled clinical trial evaluated the efficacy and safety of a standardized Rosa chinensis petal extract (RPE; NOVAROSE®) in 100 healthy men and women aged 25-65 years over 12 weeks. Participants received one tablet per day containing 300 mg of RPE or placebo. Skin parameters were assessed at baseline, week 6, and week 12 using validated instruments. RPE supplementation significantly improved wrinkle indices, skin roughness, elasticity, dermal density, and sagging compared with placebo. Additionally, RPE increased hydration, reduced transepidermal water loss, and decreased stratum corneum desquamation, reflecting enhanced barrier and renewal functions. Additionally, RPE significantly improved skin hydration and barrier function, as evidenced by increased hydration, reduced transepidermal water loss, decreased stratum corneum desquamation, and enhanced skin brightness (L*). Compliance exceeded 95%, and no serious adverse events were reported. These findings provide the first clinical evidence that anthocyanin-containing RPE supplementation yields meaningful improvements in both structural and functional markers of skin health. RPE is a safe, plant-based nutraceutical with potential as a systemic oral strategy for managing photoaging.","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":"196-204"},"PeriodicalIF":1.8,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147365851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fermented Whey Protein Supplement Slows the Progression of Frailty and Sarcopenia Among Older Korean Adults: A Randomized Blinded Trial. 发酵乳清蛋白补充剂减缓韩国老年人虚弱和肌肉减少症的进展：一项随机盲法试验。

IF 1.8 3区农林科学

Journal of medicinal food Pub Date : 2026-04-01 Epub Date: 2026-03-10 DOI: 10.1177/1096620X261430172

Hee-Sook Lim, Dong Hoon Jung, Ha Yul Kim, Jung Wan Lee, Young Sun Kim, Hyeri Shin

{"title":"Fermented Whey Protein Supplement Slows the Progression of Frailty and Sarcopenia Among Older Korean Adults: A Randomized Blinded Trial.","authors":"Hee-Sook Lim, Dong Hoon Jung, Ha Yul Kim, Jung Wan Lee, Young Sun Kim, Hyeri Shin","doi":"10.1177/1096620X261430172","DOIUrl":"10.1177/1096620X261430172","url":null,"abstract":"As the global population ages, frailty and sarcopenia have emerged as pressing public health challenges due to their impact on functional decline and increased health care burden. This study assessed the efficacy of lactic acid bacteria-fermented whey protein (LAB-FWP) supplementation for improving physical function and nutritional markers in community-dwelling older Korean adults. A total of 45 individuals aged 65 years and older (body mass index 18.5-30) who had not used protein supplements in the prior 6 months were enrolled in a 10-week, randomized, blinded trial. Participants were assigned to either the intervention group (n = 22), which received 38 g/day of LAB-FWP, or the control group (n = 23), which received a taste- and texture-matched dextrin placebo. The intervention group demonstrated significant improvements in physical performance, including an increase in electronic Short Physical Performance Battery (eSPPB) scores (P = .034) and hand grip strength (P = .043). Nutritional biomarkers also improved markedly: dietary vitamin D intake increased from 2.2 to 11.6 µg, calcium intake from 280.9 to 566.7 mg, and magnesium intake from 135.5 to 316.3 mg (all P < .001). Compared with controls, the intervention group showed greater gains in skeletal muscle mass index (Δ = 1.5, P = .004) and eSPPB scores (Δ = 1.4, P = .017). Regression analysis revealed that physical function was positively associated with improvements in nutrition. Daily supplementation with LAB-FWP led to clinically meaningful enhancements in both functional capacity and nutritional status, suggesting its potential as a practical strategy to mitigate age-related frailty and sarcopenia.","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":"205-213"},"PeriodicalIF":1.8,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147389948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparative Effects of Agastache rugosa Extract and a Complex of Agastache rugosa, Ficus carica, and Lycium barbarum Extracts on Skin Aging: A Randomized, Double-Blind, Placebo-Controlled Trial. 山茱萸提取物与山茱萸、无花果和枸杞提取物复合物对皮肤衰老的比较作用：一项随机、双盲、安慰剂对照试验。

IF 1.8 3区农林科学

Journal of medicinal food Pub Date : 2026-04-01 Epub Date: 2026-03-12 DOI: 10.1177/1096620X261431197

YoungWoo Cho, Jiahao Shen, Jun Li, JinHee Yoo

{"title":"Comparative Effects of Agastache rugosa Extract and a Complex of Agastache rugosa, Ficus carica, and Lycium barbarum Extracts on Skin Aging: A Randomized, Double-Blind, Placebo-Controlled Trial.","authors":"YoungWoo Cho, Jiahao Shen, Jun Li, JinHee Yoo","doi":"10.1177/1096620X261431197","DOIUrl":"10.1177/1096620X261431197","url":null,"abstract":"Skin aging, driven by intrinsic and extrinsic factors, leads to wrinkles and dryness, primarily due to reduced levels of collagen and hyaluronic acid. Agastache rugosa extract (Agatri®, AG) and a complex of A. rugosa, Ficus carica, and Lycium barbarum extracts (AGEs Blocker™, AB) have been suggested to support skin health in previous studies. Based on preclinical evidence supporting AB's superior efficacy compared to AG, we aimed to investigate whether these effects could also be observed in humans. To this end, we directly compared the effects of AG and AB on skin parameters in a randomized, double-blind, placebo-controlled trial. Forty-five participants were randomized to receive AG (1000 mg/day), AB (500 mg/day), or maltodextrin tablets for 12 weeks. After 8 and 12 weeks of supplementation, both AG and AB significantly reduced wrinkle size and transepidermal water loss compared to placebo. The skin moisture content, dermal density, and elasticity were also improved by supplementation with AG and AB. Notably, AB demonstrated greater efficacy than AG in enhancing these skin parameters. Taken together, this study provides the first clinical evidence that both AG and AB supplementation improves multiple features of skin aging, with AB demonstrating superior efficacy. These findings suggest that AG and AB may serve as promising candidates for the development of dietary supplements targeting skin health.","PeriodicalId":16440,"journal":{"name":"Journal of medicinal food","volume":" ","pages":"214-221"},"PeriodicalIF":1.8,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147433766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0