Journal of Medical Primatology最新文献

{"title":"Characteristics of the Serum Microbiota and Circulating Metabolites in Cynomolgus Monkeys With Spontaneous Type 2 Diabetes Mellitus","authors":"Chaoyang Tian,&nbsp;Qunhui Yang,&nbsp;Haizhou Lv,&nbsp;Feng Yue","doi":"10.1111/jmp.12738","DOIUrl":"https://doi.org/10.1111/jmp.12738","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Type 2 diabetes mellitus (T2DM) is widely recognized as a serious global public health concern with a substantial economic burden on patients, their families, and society. Accumulating evidence suggests that an etiologic role for serum microbiota and circulating metabolites in the pathogenesis of T2DM. This study aims to characterize the serum microbiota and circulating metabolites in cynomolgus monkeys with spontaneous T2DM, and provide a reference for the diagnosis and treatment of clinical T2DM.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We collected serum samples of the 14 cynomolgus monkeys (15–20 years old, male) for serum microbiota analysis by 16S rRNA gene V3-V4 region amplicon sequencing and circulating metabolites analysis by ultra-high-performance liquid chromatography–tandem mass spectrometry, of which seven were spontaneous T2DM cynomolgus monkeys and seven were healthy controls.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Our results showed that the serum microbiota abundance and diversity were significantly increased in cynomolgus monkeys with spontaneous T2DM compared to healthy controls, the phyla of <i>Cyanobacteria</i> and <i>Chloroflexi</i> and the genera of <i>Lactobacillus, rhodobacter</i> and <i>collinsella</i> were also significantly increased. A total of 114 serum differentially expressed metabolites (DEMs) were identified, of which 22 were selected as potential biomarkers candidates related to spontaneous T2DM in cynomolgus monkeys by multivariate data analysis. In addition, serum levels of total SCFAs, acetate, butyrate, caproate, isobutyrate, and isovalerate were also significantly increased in the present study. The correlation network analyses have selected certain key DEMs, such as D-Psicose, 4-Oxoproline, D-Glutamine, and Hydroxyphenyllactic acid, which may serve as potential biomarkers for distinguishing between T2DM and healthy controls.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Our results provide preliminary insights on perturbed serum microbiota and circulating metabolites of cynomolgus monkeys with spontaneous T2DM. These findings would be useful to develop microbiota-based strategies for T2DM prevention and control.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16439,"journal":{"name":"Journal of Medical Primatology","volume":"53 5","pages":""},"PeriodicalIF":0.8,"publicationDate":"2024-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142276648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Experimental Study to Optimize Neuromuscular Blockade Protocols in Cynomolgus Macaques: Monitoring, Doses, and Antagonism","authors":"Hélène Letscher,&nbsp;Julien Lemaitre,&nbsp;Emma Burban,&nbsp;Roger Le Grand,&nbsp;Pierre Bruhns,&nbsp;Francis Relouzat,&nbsp;Aurélie Gouel-Chéron","doi":"10.1111/jmp.12736","DOIUrl":"https://doi.org/10.1111/jmp.12736","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Neuromuscular blocking agents (NMBAs) are a crucial component of anesthesia and intensive care through the relaxation of skeletal muscles. They can lead to adverse reactions such as postoperative residual neuromuscular block. Only one agent is capable of an instant block reversal in deep block situations, but is restricted to aminosteroid agents. Among animal models, non-human primates are an essential model for a great diversity of human disease models. The main objective of this study was to establish a model for NMBA monitoring with current available drugs before testing new reversal agents.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Seven healthy male cynomolgus macaques were randomly assigned to this study. Experiments using macaques were approved by the local ethical committee (CEtEA #44). All animals were anesthetized according to institutional guidelines, with ketamine and medetomidine, allowing IV line placement and tracheal intubation. Anesthesia was maintained with isoflurane. Either rocuronium bromine (with or without sugammadex reversal) or atracurium besylate was evaluated. Monitoring was performed with two devices, TOF-Watch and ToFscan, measuring the T4/T1 and the T4/Tref ratios, respectively. Nonparametric Mann–Whitney statistical analyses were done when indicated.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>NMBA monitoring required adaptation compared to humans, such as stimulus intensity and electrode placement, to be efficient and valid in cynomolgus macaques. When administered, both NMBAs induced deep and persistent neuro-muscular block at equivalent doses to clinical doses in humans. The rocuronium-induced profound neuromuscular block could be reversed using the cyclodextrin sugammadex as a reversal agent. We report no adverse effects in these models by clinical observation, blood chemistry, or complete blood count.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>These results support the use of non-human primate models for neuromuscular block monitoring. This represented the first step before the forthcoming testing of new NMBA-reversal agents.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16439,"journal":{"name":"Journal of Medical Primatology","volume":"53 5","pages":""},"PeriodicalIF":0.8,"publicationDate":"2024-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jmp.12736","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142276649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diffuse Large B-Cell Lymphoma in a Cynomolgus Monkey","authors":"Heling Li,&nbsp;Long Zhang,&nbsp;Zhigang Chen,&nbsp;Faliang Zong,&nbsp;Baohong Tian,&nbsp;Xinglong Chen,&nbsp;Deli Liu,&nbsp;Qing Ning,&nbsp;Hong Wang","doi":"10.1111/jmp.12734","DOIUrl":"10.1111/jmp.12734","url":null,"abstract":"<div>\u0000 \u0000 <p>A captive 17-year-old male cynomolgus monkey (<i>Macaca fascicularis</i>) developed diffuse large B-cell lymphoma (DLBCL). This was the first report of DLBCL presenting with a mandible mass and violation of the paranasal sinus in a cynomolgus monkey. The neoplasm showed marked microscopical malignant aspects. Immunohistochemical staining showed strong positive expression of CD20. These features may contribute to the diagnosis and therapeutics of DLBCL in NHPs.</p>\u0000 </div>","PeriodicalId":16439,"journal":{"name":"Journal of Medical Primatology","volume":"53 5","pages":""},"PeriodicalIF":0.8,"publicationDate":"2024-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142154396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Successful Treatment of Cryptococcus gattii in an Immunocompetent Adult Rhesus Macaque (Macaca mulatta)","authors":"Joshua M. Taylor,&nbsp;Cassandra O. Cullin,&nbsp;Andrew J. Haertel,&nbsp;Anne D. Lewis,&nbsp;Lauren Renner","doi":"10.1111/jmp.12733","DOIUrl":"10.1111/jmp.12733","url":null,"abstract":"<div>\u0000 \u0000 <p>An adult female rhesus macaque presented during routine annual physical examination for evaluation of a 2.5-cm diameter superficial ulcerated dermal lesion that was subsequently diagnosed as a systemic fungal infection caused by <i>Cryptococcus gattii</i>. <i>Cryptococcus gattii</i> is one of several basidiomycetic yeasts responsible for pulmonary, neurologic, and disseminated infections in humans and animals. This report describes the diagnosis, management, and clinical resolution of a <i>C. gattii</i> infection in an immunocompetent 5-year-old female rhesus macaque.</p>\u0000 </div>","PeriodicalId":16439,"journal":{"name":"Journal of Medical Primatology","volume":"53 5","pages":""},"PeriodicalIF":0.8,"publicationDate":"2024-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142154397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Staphylococcus spp. as part of the microbiota and as opportunistic pathogen in free-ranging black-tuffed marmosets (Callithrix penicillata) from urban areas: Epidemiology, antimicrobial resistance, and pathology","authors":"Daniel Oliveira dos Santos,&nbsp;Bruna Hermine de Campos,&nbsp;Thayanne Gabryelle Viana de Souza,&nbsp;Yasmin Gonçalves de Castro,&nbsp;Geraldo Alves Neto,&nbsp;André Duarte Vieira,&nbsp;Letícia Neves Ribeiro,&nbsp;Caio Castro Cunha de Figueiredo,&nbsp;Janaina Ribeiro Duarte,&nbsp;Vinícius Henrique Barbosa Amaral,&nbsp;Lucas Reis de dos Souza,&nbsp;Nayara Ferreira de Paula,&nbsp;Carlyle Mendes Coelho,&nbsp;Herlandes Penha Tinoco,&nbsp;Ayisa Rodrigues Oliveira,&nbsp;Marcelo Pires Nogueira de Carvalho,&nbsp;Rodrigo Otávio Silveira Silva,&nbsp;Renato Lima Santos","doi":"10.1111/jmp.12732","DOIUrl":"10.1111/jmp.12732","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Marmosets (<i>Callithrix</i> sp.), including black-tuffed marmosets (<i>C. penicillata</i>), are neotropical primates that can be highly adapted to urban environments, especially parks and forested areas near cities. <i>Staphylococcus</i> spp. are part of the microbiota of many different hosts and lead to opportunistic severe infection. Isolates from wild animals can be resistant to antimicrobial drugs. However, there are a few studies that evaluated <i>Staphylococcus</i> spp. in neotropical primates. The goal of this study was to evaluate <i>Staphylococcus</i> spp. isolated from free-ranging black-tuffed marmosets.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Marmosets were captured in six urban parks. After sedation, skin and rectal swabs and feces were sampled. <i>Staphylococcus</i> spp. isolates were identified by MALDI-ToF and their antimicrobial susceptibility was determined.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Over 30% of captured individuals were positive for <i>Staphylococcus</i> spp., and <i>S. aureus</i> was the most isolated species followed by <i>Mammaliicoccus</i> (<i>Staphylococcus</i>) <i>sciuri</i>. With the exception of the marmoset subjected to necropsy, none of the other had lesions, which supports that notion that <i>Staphylococcus</i> spp. are members of the microbiota, but also opportunistic pathogens. Most isolates were susceptible to all antimicrobials tested; however, one isolate of <i>S. epidermidis</i> was resistant to multiple antimicrobials (penicillin, cefoxitin, ciprofloxacin, clindamycin, and erythromycin). We considered <i>S. aureus</i> as the main staphylococci to colonize black-tuffed marmosets.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Black-tuffed marmosets can be colonized by several <i>Staphylococcus</i> species, most frequently by <i>S. aureus</i>, and the majority of isolates were sensible to the antimicrobials tested. One <i>S. epidermidis</i> isolate was considered multidrug resistant.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16439,"journal":{"name":"Journal of Medical Primatology","volume":"53 5","pages":""},"PeriodicalIF":0.8,"publicationDate":"2024-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142004483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterizing the gastrointestinal microbiome diversity in endangered Malayan Siamang (Symphalangus syndactylus): Insights into group composition, age variability and sex-related patterns","authors":"Nur Hartini Sariyati,&nbsp;Nursyuhada Othman,&nbsp;Nurfatiha Akmal Fawwazah Abdullah-Fauzi,&nbsp;Eddie Chan,&nbsp;Badrul Munir Md-Zain,&nbsp;Kayal Vizi Karuppannan,&nbsp;Muhammad Abu Bakar Abdul-Latiff","doi":"10.1111/jmp.12730","DOIUrl":"10.1111/jmp.12730","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>The gut morphology of <i>Symphalangus syndactylus</i> exhibits an intermediate structure that aligns with its consumption of fruit and ability to supplement its diet with leaves. The Siamang relies on its gut microbiome for energy extraction, immune system development, and the synthesis of micronutrients. Gut microbiome composition may be structured based on several factors such as age, sex, and habitat. No study has yet been carried out on the gut microbiota of the Hylobatidae members in Malaysia especially <i>S. syndactylus.</i></p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This study aims to resolve the gut microbiome composition of <i>S. syndactylus</i> by using a fecal sample as DNA source, adapting high-throughput sequencing, and 16S rRNA as the targeted region.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of 1 272 903 operational taxonomic units (OTUs) reads were assigned to 22 phyla, 139 families, and 210 genera of microbes. The {Unknown Phylum} Bacteria-2 is the dominant phyla found across all samples. Meanwhile, {<i>Unknown Phylum</i>} <i>Bacteria-2</i> and <i>Firmicutes</i> are genera that have the highest relative abundance found in the Siamang gut.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>This study yields nonsignificance relationship between Siamang gut microbiome composition with these three factors: group, sex, and age.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16439,"journal":{"name":"Journal of Medical Primatology","volume":"53 5","pages":""},"PeriodicalIF":0.8,"publicationDate":"2024-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141988181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiological characterization of oral focal epithelial hyperplasia in brown howler monkeys (Alouatta guariba clamitans)","authors":"Sandy Lorena Pulecio-Santos,&nbsp;Alex Junior Souza de Souza,&nbsp;Lilian Rose Marques de Sá","doi":"10.1111/jmp.12728","DOIUrl":"10.1111/jmp.12728","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Oral focal epithelial hyperplasia (FEH) is an uncommon infection affecting humans, chimpanzees, bonobos, and howler monkeys. This study describes 10 cases of free-ranging brown howler monkeys (<i>Alouatta guariba</i> clamitans) diagnosed with FEH and <i>Alouatta guariba</i> Papillomavirus 1 (AgPV 1).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We analyzed demographic characteristics, rescue conditions, clinical and pathological findings, and species-specific behavior factors in these cases. The study assessed the frequency of occurrence and potential contributing factors of FEH and AgPV 1 infection.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The frequency of FEH was 8.13%. Most affected howlers were adult or geriatric males with comorbidities or stressful conditions. Clinical and pathological observations were consistent with AgPV 1 infection. Species-specific behaviors and environmental stressors were identified as contributing factors.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>FEH associated with AgPV 1 affected mainly adult or geriatric males with ongoing comorbidities or stressful conditions. Further research is needed to understand these factors for effective management.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16439,"journal":{"name":"Journal of Medical Primatology","volume":"53 4","pages":""},"PeriodicalIF":0.8,"publicationDate":"2024-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141988180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Morphometry and skeletopy of kidneys and renal vessels in marmoset (Callithrix spp.)","authors":"Rafaela Dünkel-Duarte,&nbsp;Thais Mattos Estruc,&nbsp;Renata Medeiros do Nascimento,&nbsp;Alcides Pissinatti,&nbsp;Paulo de Souza-Júnior,&nbsp;Carlos Augusto dos Santos-Sousa,&nbsp;Marcelo Abidu-Figueiredo","doi":"10.1111/jmp.12731","DOIUrl":"10.1111/jmp.12731","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Marmosets, <i>Callithrix</i> spp, are small New World monkeys that have gained importance as an experimental animal model for human. Despite its use, information on its renal morphometry, vascularization, and location are limited. Therefore, this study will supply basic anatomy for applied studies and for comparative anatomy.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Fifty cadavers of <i>Callithrix</i> spp were collected on highways from the Atlantic Forest biome, identified and injected with a 10% formaldehyde solution. Later, the specimens were dissected and the measurements and topography of the kidneys and renal vessels were recorded. Both left and right kidneys were significantly larger in females.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>In the specimens studied, the average body length was 20.00 ± 2.46 cm in males and 20.50 ± 1.98 cm in females (<i>p</i> = .43). The kidneys of the <i>Callithrix</i> spp. were symmetrical in shape and resembled a “bean.” They were also pale brown with a smooth surface. In males, the most frequent location of the right kidney was at the L1–L2 level (92%), while the location of the left kidney was between L2 and L3 (76%). In females, the most frequent location of the right kidney was at the L1–L2 level (56%), while the location of the left kidney was between L2 and L3 (32%) (Table 1). However, in seven (28%) males and nine (36%) females, the kidneys were at the same level.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>In both sexes, there was a positive and significant linear correlation between body length and kidney length. Regardless of the variable location of the kidneys in both sides and in either sexe, the right kidney was always located more cranially than the left, similar to observations in other non-human primates.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16439,"journal":{"name":"Journal of Medical Primatology","volume":"53 4","pages":""},"PeriodicalIF":0.8,"publicationDate":"2024-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141971308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serological evidence of exposition to Toxoplasma gondii in Saimiri spp. kept in a research institution as biomodels in Rio de Janeiro","authors":"Carolina Andrade de Oliveira,&nbsp;Igor Falco Arruda,&nbsp;Alynne da Silva Barbosa,&nbsp;Thalita de Abreu Pissinatti,&nbsp;Helio Langoni,&nbsp;Maria Regina Reis Amendoeira","doi":"10.1111/jmp.12729","DOIUrl":"10.1111/jmp.12729","url":null,"abstract":"<p>Anti-<i>Toxoplasma gondii</i> antibodies were investigated in 125 <i>Saimiri</i> spp. kept at a research institute. A total of 12% of primates tested positive, all of which were <i>Saimiri sciureus</i>. These results highlight the need to minimize the possibility of this protozoan's circulation, which can lead to fulminant infection in these animals.</p>","PeriodicalId":16439,"journal":{"name":"Journal of Medical Primatology","volume":"53 4","pages":""},"PeriodicalIF":0.8,"publicationDate":"2024-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141889488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic features of metastatic endometrioid carcinoma in a captive black-tufted marmoset (Callithrix penicillata)","authors":"Isabel Luana de Macêdo,&nbsp;Davi Emanuel Ribeiro de Sousa,&nbsp;Mariana Mattioli,&nbsp;Betânia Pereira Borges,&nbsp;Eduardo Mauricio Mendes de Lima,&nbsp;Márcio Botelho de Castro","doi":"10.1111/jmp.12727","DOIUrl":"10.1111/jmp.12727","url":null,"abstract":"<p>A captive marmoset developed metastatic endometrioid carcinoma (EnC), a rare uterine tumor in non-human primates (NHPs). The neoplasm showed marked microscopical malignant and tubulopapillary aspects, immunopositivity for pan-cytokeratin, CK7, estrogen receptor, and a high mitotic index (Ki-67). These features may contribute to the diagnosis and therapeutics of EnC in NHPs.</p>","PeriodicalId":16439,"journal":{"name":"Journal of Medical Primatology","volume":"53 4","pages":""},"PeriodicalIF":0.8,"publicationDate":"2024-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141889487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}