Journal of Medical Primatology最新文献

{"title":"The Owl Monkey (Aotus spp.) as an Animal Research Model—Part 1: Taxonomy, Geographic Distribution, Anatomy, and Behavior","authors":"Alfonso S. Gozalo,&nbsp;William R. Elkins","doi":"10.1111/jmp.70022","DOIUrl":"https://doi.org/10.1111/jmp.70022","url":null,"abstract":"<div>\u0000 \u0000 <p>Owl monkeys (<i>Aotus</i> spp.) are the only nocturnal simian primates and, as such, they are very different from other nonhuman primate species. Despite owl monkeys being used as animal models to study malaria for over 50 years, there is not much information about their requirements in captivity compared to other primate species commonly used in biomedical research. This may be due to the fact that owl monkeys are nocturnal, making them more difficult to study in their natural environment. Information about their natural environment and behavior is important for designing the most appropriate husbandry for these species in captivity. Here we briefly review the taxonomy, geographic distribution, anatomy, and behavior of the owl monkey in hopes that it will be useful for animal care personnel and researchers designing and conducting research with this invaluable animal model.</p>\u0000 </div>","PeriodicalId":16439,"journal":{"name":"Journal of Medical Primatology","volume":"54 3","pages":""},"PeriodicalIF":0.8,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143871683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pitted Keratolysis in an Olive Baboon (Papio anubis)","authors":"Emily A. Blackwell,&nbsp;Ryan C. Navarro,&nbsp;Katti R. Crakes,&nbsp;Amanda R. Maxwell,&nbsp;John G. Trupkiewicz","doi":"10.1111/jmp.70019","DOIUrl":"https://doi.org/10.1111/jmp.70019","url":null,"abstract":"<div>\u0000 \u0000 <p>Pitted keratolysis, a dermatologic condition in humans, was diagnosed in an olive baboon (<i>Papio anubis</i>) via biopsy and responded well to topical treatment. In humans, pitted keratolysis is caused by the overgrowth of keratinolytic bacteria within the stratum corneum. This represents the first reported case in a nonhuman primate.</p>\u0000 </div>","PeriodicalId":16439,"journal":{"name":"Journal of Medical Primatology","volume":"54 2","pages":""},"PeriodicalIF":0.8,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143831102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hematological and Biochemical Profile of Callithrix kuhlii (COIMBRA-FILHO, 1985) in Urban and Peri-Urban Areas of Southern Bahia, Brazil","authors":"Antônio Victor Veloso Ramos,&nbsp;Sofía Bernal-Valle,&nbsp;Ana Vitória Dias do Nascimento,&nbsp;Letícia Soto da Costa,&nbsp;Lucas Eduardo França Sarubi,&nbsp;Pedro Vinícius Japiassú de Almeida Nunes,&nbsp;Filipe Vieira Santos de Abreu,&nbsp;Fabrício Souza Campos,&nbsp;Danilo Simonini Teixeira","doi":"10.1111/jmp.70020","DOIUrl":"https://doi.org/10.1111/jmp.70020","url":null,"abstract":"<p>Brazil harbors the greatest diversity of primates, and among them, the genus <i>Callithrix</i> is notable for its adaptation to urban environments. Despite being endemic to southern Bahia and northeastern Minas Gerais, the Wied's marmoset (<i>Callithrix kuhlii</i>) remains understudied, highlighting the need for baseline health data. This study aimed to characterize the hematological and biochemical profiles of <i>C. kuhlii</i> in urban and peri-urban areas within its distribution range. A total of 106 wild marmosets were captured, and blood samples were collected from the femoral plexus of the individuals. Hematological parameters showed no significant differences between sexes. However, sex-based variations were observed in serum biochemistry, with males showing higher triglycerides and urea levels, possibly influenced by dietary factors and testosterone. This pioneering study establishes essential baseline data on the hematology and biochemistry parameters of <i>C. kuhlii</i> in the wild, supporting future research on its ecology and conservation within the Atlantic Forest.</p>","PeriodicalId":16439,"journal":{"name":"Journal of Medical Primatology","volume":"54 2","pages":""},"PeriodicalIF":0.8,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jmp.70020","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143831098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the Hematological and Biochemical Profile of Leontopithecus chrysomelas (Kuhl, 1820) Under Ex-Situ Conditions","authors":"Gabriel Feliciano Felizardo,&nbsp;Silvia Bahadian Moreira,&nbsp;Alcides Pissinatti,&nbsp;Amanda de Oliveira Alcantara,&nbsp;Guilherme N. Souza,&nbsp;Aline Moreira de Souza","doi":"10.1111/jmp.70018","DOIUrl":"https://doi.org/10.1111/jmp.70018","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <p><i>Leontopithecus chrysomelas</i> is a neotropical primate in danger of extinction and its ex-situ maintenance is one of the species' conservation and preservation strategies. Knowledge of biological standards of normality, such as hematological and biochemical analytes, provides valuable information on the animals' state of health and aids in the diagnosis of diseases.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Blood samples from 65 individuals of the species <i>L. chrysomelas</i> were collected and analyzed for complete blood count analytes and biochemical analytes. Each variable was statistically analyzed according to the ASVCP guidelines and compared between the sexes.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>This study provides hematological and biochemical reference values for <i>L. chrysomelas</i> under humane care. Statistical differences were observed between the sexes in hematological and biochemical analytes. Differences were observed in hemoglobinometry and mean corpuscular volume (MCV), in which males showed higher values (<i>p</i> &lt; 0.05). Considering the biochemical analytes, the males of <i>L. chrysomelas</i> showed higher alkaline phosphatase values compared to the females (<i>p</i> &lt; 0.05).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Our study provides the first reports of hematological and biochemical reference values for <i>L. chrysomelas</i> ex-situ. The normal ranges described can be used for the management, diagnosis, monitoring, and disease prevention of animals in similar conditions.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16439,"journal":{"name":"Journal of Medical Primatology","volume":"54 2","pages":""},"PeriodicalIF":0.8,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143778251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Desmoplastic Ameloblastoma in a Specimen of Alouatta caraya (Primates, Atelidae) From Northeastern Argentina","authors":"Carlos A. Luna,&nbsp;María Belén Natalini,&nbsp;Carolina Repetto,&nbsp;Francisco Sanchez Gavier,&nbsp;Pedro Cuaranta,&nbsp;Martín M. Kowalewski","doi":"10.1111/jmp.70015","DOIUrl":"https://doi.org/10.1111/jmp.70015","url":null,"abstract":"<div>\u0000 \u0000 <p>Different studies have indicated that there is a high prevalence of neoplasms in nonhuman primates; however, in Platyrrhini species, and especially in South American species, the available information is very scarce. The black howler monkey (<i>Alouatta caraya</i>) is the most widely distributed species in northeastern Argentina. In this contribution, we report an adult male individual of <i>A. caraya</i> with an important maxillofacial lesion whose morphological and radiographic characteristics allow us to diagnose it as the first record of a desmoplastic ameloblastoma in this species. The occurrence of this benign neoplasm raises the need to increase population monitoring, as well as the postmortem analysis of the different carcasses recovered from the different regions inhabited by this species.</p>\u0000 </div>","PeriodicalId":16439,"journal":{"name":"Journal of Medical Primatology","volume":"54 2","pages":""},"PeriodicalIF":0.8,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143770409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mitochondrial Complex I Molecular Alterations in Sapajus apella as a Human Gastric Carcinogenesis Model After MNU Exposure","authors":"Bárbara dos Santos Dias,&nbsp;Symara Rodrigues Antunes,&nbsp;Danilo do Rosário Pinheiro,&nbsp;Rommel Mario Rodriguez Burbano,&nbsp;Bárbara do Nascimento Borges","doi":"10.1111/jmp.70017","DOIUrl":"https://doi.org/10.1111/jmp.70017","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Gastric cancer (GC) remains among the top five global health problems. Therefore, comprehending the tumor energetic behavior is critical to understanding its progression. This study aimed to investigate mitochondrial DNA (mtDNA) alterations in GC cancer cell lines in an animal model.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Material and Methods</h3>\u0000 \u0000 <p>Four mitochondrial genes (<i>COI</i>, <i>ATP8</i>, <i>ND1</i>, and <i>ND3</i>) were analyzed in GC (AGP01, ACP02, ACP03, and PG100) and control (Walker 256 carcinosarcoma) cell lines inoculated in <i>Sapajus apella</i>, exposed and not exposed to N-methyl-N-nitrosourea.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Two synonymous alterations were identified in <i>ND1</i>. In <i>ND3</i>, a non-synonymous alteration (A10398G ➔ Thr114Ala) may decrease the respiratory chain Complex I efficiency, enhancing cellular reactive oxygen species and contributing to mtDNA damage. As alterations in <i>ND1</i> and <i>ND3</i> were observed in highly aggressive cell lines, our results suggest these genes may play crucial roles in energetic efficiency and gastric carcinogenesis.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16439,"journal":{"name":"Journal of Medical Primatology","volume":"54 2","pages":""},"PeriodicalIF":0.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jmp.70017","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143741224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pseudomonas Infections in the Common Marmoset (Callithrix jacchus): Gross and Histopathological Findings","authors":"Victoria D. Silva,&nbsp;Pragathi B. Shridhar,&nbsp;Olga D. Gonzalez,&nbsp;Edward J. Dick Jr.,&nbsp;Vinay Shivanna","doi":"10.1111/jmp.70016","DOIUrl":"https://doi.org/10.1111/jmp.70016","url":null,"abstract":"<div>\u0000 \u0000 <p>Common marmosets (<i>Callithrix jacchus</i>) are a New World nonhuman primate (NHP) whose popularity as a research model continues to expand. Marmosets were identified as the predominant NHP species that is susceptible to spontaneous <i>Pseudomonas</i> infections based on a 27-year survey in a primate colony, encompassing several NHP species. 26 common marmosets were retrospectively identified and evaluated for spontaneous <i>Pseudomonas</i> spp. infections. Clinical symptoms included lethargy, weight loss, gastrointestinal issues (diarrhea, bloating, vomiting, poor appetite), increased respiratory effort, and difficulty urinating. Affected organs (larynx, lungs, liver, gallbladder, intestines, colon, uterus, and urinary bladder) appeared discolored, distended, or enlarged. Microscopic findings included inflammatory infiltrates, edema, necrosis, hemorrhage, and pseudomembranous lesions. Only animals with clinical symptoms or gross evidence of bacterial infection were cultured; therefore, the actual incidence of <i>Pseudomonas</i> spp. infections is unknown. We present the common and uncommon lesions associated with <i>Pseudomonas</i> infections in the common marmoset.</p>\u0000 </div>","PeriodicalId":16439,"journal":{"name":"Journal of Medical Primatology","volume":"54 2","pages":""},"PeriodicalIF":0.8,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143741225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Renal Cell Carcinoma in a Common Marmoset: First Report and a Brief Review of Nonhuman Primate Literature","authors":"Taysia Battee,&nbsp;Olga Gonzalez,&nbsp;Phil S. Medlin,&nbsp;Edward J. Dick Jr,&nbsp;Vinay Shivanna","doi":"10.1111/jmp.70014","DOIUrl":"https://doi.org/10.1111/jmp.70014","url":null,"abstract":"<div>\u0000 \u0000 <p>Renal cell carcinoma (RCC) is a malignant form of urogenital cancer that arises from renal tubular epithelial cells. Here, we describe a case of renal cell carcinoma in a common marmoset (<i>Callithrix jacchus</i>). Immunohistochemistry demonstrated positive reactivity for PAX8 and CD10 in the renal neoplasm. We review 115 cases of spontaneous renal tumors in nonhuman primates (NHP) reported in the literature and from the Southwest National Primate Research Center records. Across all NHPs, malignant renal neoplasms were more frequent than benign. There appears to be a male sex predilection for renal tumors in baboons. This is the first reported case of renal cell carcinoma in a marmoset.</p>\u0000 </div>","PeriodicalId":16439,"journal":{"name":"Journal of Medical Primatology","volume":"54 2","pages":""},"PeriodicalIF":0.8,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143717377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microbiome-Metabolomics Analysis of the Impacts of Balantidium Coli Infection in Rhesus Monkeys (Macaca mulatta)","authors":"Heling Li,&nbsp;Long Zhang,&nbsp;Faliang Zong,&nbsp;Baohong Tian,&nbsp;Xinglong Chen,&nbsp;Hong Wang","doi":"10.1111/jmp.70013","DOIUrl":"https://doi.org/10.1111/jmp.70013","url":null,"abstract":"<div>\u0000 \u0000 <p><i>Balantidium coli</i> (<i>B. coli</i>) is a prevalent intestinal parasite in monkeys, significantly impacting their health. Previous studies have demonstrated that <i>B. coli</i> infection in pigs leads to severe dysregulation of the gut microbiota. However, there has been no report on the alterations in fecal microbiota and metabolites in rhesus monkeys infected with <i>B. coli</i>. In order to investigate the differences in gut microbiota and metabolites between healthy rhesus monkeys and those infected with <i>B. coli</i>, we conducted gene sequencing and gas chromatography–mass spectrometry (GC–MS) analysis of fecal samples from 6 healthy rhesus monkeys and 5 rhesus monkeys infected with <i>B. coli</i>. The results revealed significant differences in the composition of gut microbiota between rhesus monkeys infected with <i>B. coli</i> and healthy ones (<i>p</i> &lt; 0.01). The abundance of <i>Campylobacterota</i> was significantly increased (<i>p</i> &lt; 0.01), while the abundance of <i>Bacteroidota</i> was significantly decreased (<i>p</i> &lt; 0.05). <i>Prevotella</i> 9 was the dominant genus in both groups, showing a significant increase in the infected group (<i>p</i> &lt; 0.05). At the species level, <i>Brachyspira hampsonii</i> was significantly increased in the infected group (<i>p</i> &lt; 0.01), whereas <i>Prevotella copri</i>, which was the dominant species in both groups, showed a significant decrease in the infected group (<i>p</i> &lt; 0.05). Metabolomics studies indicated a significant decrease in levels of metabolites such as dihydrolipoamide, 9(Z),11(E)-Conjugated Linoleic Acid, and 8,9-DiHETrE within fecal samples from rhesus monkeys infected with <i>B. coli</i> (<i>p</i> &lt; 0.05). Correlation analysis of the microbiome and metabolome suggested a close relationship between differential microbiota and metabolites. In conclusion, this study suggests that the colonization of <i>B. coli</i> is associated with dysbiosis of the monkey gut microbiota. This study provides a new insight that using intestinal microbes instead of antibiotics to treat balantidiosis can also serve as a reference for further research on the relationship between gut microbiota and metabolomics in host infections by other protozoa.</p>\u0000 </div>","PeriodicalId":16439,"journal":{"name":"Journal of Medical Primatology","volume":"54 2","pages":""},"PeriodicalIF":0.8,"publicationDate":"2025-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143632624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hematological Profile of Naturally Infected Long-Tailed Macaques (Macaca fascicularis) With Plasmodium Inui in Ex Situ Captivity Prior to Ex Vivo Cultivation","authors":"Risqa Novita,&nbsp;Agik Suprayogi,&nbsp;Andria Agusta,&nbsp;Arifin Budiman Nugraha,&nbsp;Huda Shalahudin Darusman","doi":"10.1111/jmp.70011","DOIUrl":"https://doi.org/10.1111/jmp.70011","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Anemia, characterized by low hemoglobin, is a key malaria indicator. Malaria in non-human primates (NHPs) is often asymptomatic, requiring laboratory tests and microscopy for diagnosis. Hematological profiles are crucial for understanding NHP clinical conditions and supporting ex vivo <i>Plasmodium</i> culture for antimalarial testing. This study examines hematological changes in <i>Macaca fascicularis</i> naturally infected with <i>Plasmodium inui</i> and provides hematocrit guidelines for ex vivo culture.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Ten <i>M. fascicularis</i> were diagnosed with <i>Plasmodium inui</i> in 2023 and subsequently re-screened in this study through microscopic and molecular analyses. Two monkeys (M4, M10) with the highest parasitemia and one negative control (M6) were analyzed. Hematological, albumin, and glucose levels were measured.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>M4 and M10 showed 34.5% and 30.2% hematocrit values, with hemoglobin levels of 10.5 and 8.6 g/dL. M10 exhibited anemia and thrombocytopenia.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>M10 showed hematological signs of malaria, while all macaques exhibited microcytic hypochromic anemia. High hematocrit levels are recommended for ex vivo culture.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16439,"journal":{"name":"Journal of Medical Primatology","volume":"54 2","pages":""},"PeriodicalIF":0.8,"publicationDate":"2025-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143530495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}