Journal of Medical Primatology最新文献

{"title":"Hematological Profile of Naturally Infected Long-Tailed Macaques (Macaca fascicularis) With Plasmodium Inui in Ex Situ Captivity Prior to Ex Vivo Cultivation","authors":"Risqa Novita,&nbsp;Agik Suprayogi,&nbsp;Andria Agusta,&nbsp;Arifin Budiman Nugraha,&nbsp;Huda Shalahudin Darusman","doi":"10.1111/jmp.70011","DOIUrl":"https://doi.org/10.1111/jmp.70011","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Anemia, characterized by low hemoglobin, is a key malaria indicator. Malaria in non-human primates (NHPs) is often asymptomatic, requiring laboratory tests and microscopy for diagnosis. Hematological profiles are crucial for understanding NHP clinical conditions and supporting ex vivo <i>Plasmodium</i> culture for antimalarial testing. This study examines hematological changes in <i>Macaca fascicularis</i> naturally infected with <i>Plasmodium inui</i> and provides hematocrit guidelines for ex vivo culture.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Ten <i>M. fascicularis</i> were diagnosed with <i>Plasmodium inui</i> in 2023 and subsequently re-screened in this study through microscopic and molecular analyses. Two monkeys (M4, M10) with the highest parasitemia and one negative control (M6) were analyzed. Hematological, albumin, and glucose levels were measured.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>M4 and M10 showed 34.5% and 30.2% hematocrit values, with hemoglobin levels of 10.5 and 8.6 g/dL. M10 exhibited anemia and thrombocytopenia.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>M10 showed hematological signs of malaria, while all macaques exhibited microcytic hypochromic anemia. High hematocrit levels are recommended for ex vivo culture.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16439,"journal":{"name":"Journal of Medical Primatology","volume":"54 2","pages":""},"PeriodicalIF":0.8,"publicationDate":"2025-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143530495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cor Pulmonale and Secondary Pulmonary Arteriolar Hypertension in a Red Howler (Alouatta seniculus) Associated With Klebsiella pneumoniae Pneumonia","authors":"Kavita Sant,&nbsp;Jenelle Johnson,&nbsp;Rod Suepaul,&nbsp;Ignacio Corradini","doi":"10.1111/jmp.70010","DOIUrl":"https://doi.org/10.1111/jmp.70010","url":null,"abstract":"<div>\u0000 \u0000 <p>A captive red howler (<i>Alouatta seniculus</i>) monkey developed right-sided heart failure and pulmonary arteriolar hypertension associated with a <i>Klebsiella pneumoniae</i> pneumonia and typhlocolitis. Clinical signs of right-sided heart failure, along with a low-grade diastolic heart murmur and diarrhea, were present.</p>\u0000 </div>","PeriodicalId":16439,"journal":{"name":"Journal of Medical Primatology","volume":"54 2","pages":""},"PeriodicalIF":0.8,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143513828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High-Throughput DNA Metabarcoding for the Gut Microbiome Assessment of Captive White-Handed Gibbon and Siamang","authors":"Badrul Munir Md-Zain,&nbsp;Wan Ainin Sofiya Wan-Mustafa,&nbsp;Roberta Chaya Tawie Tingga,&nbsp;Millawati Gani,&nbsp;Abd Rahman Mohd-Ridwan","doi":"10.1111/jmp.70009","DOIUrl":"https://doi.org/10.1111/jmp.70009","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>The gut microbiota plays a vital role in primates' overall health and well-being, including small apes (Hylobatidae). The symbiotic relationships between bacteria and the gut aid food digestion, maintain host health, and help them adapt to their environment, including captive conditions. Despite being listed as endangered in the International Union for Conservation of Nature (IUCN) red list category, molecular studies on the small ape's gut microbiome are limited compared to other primates. This study aimed to characterize the gut microbiota of captive small apes at Zoo Taiping and Night Safari, Peninsular Malaysia, by evaluating their microbial communities.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Seven fecal samples from Hylobatidae (white-handed gibbon and siamang) were collected, and the bacteria therein were successfully isolated and subjected to high-throughput sequencing of the 16S rRNA gene.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The acquired amplicon sequence variants (ASVs) were successfully classified into 17 phyla, 82 families, 164 genera, and 43 species of microbes. Each small ape exhibited a unique gut microbiota profile. The phyla Bacteroidota and Firmicutes were dominant in each individual. Environmental conditions and host genetics are among the factors that influence the small ape's gut microbiome composition.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>These findings provide valuable insights into the gut microbiota composition of small apes at Zoo Taiping and Night Safari, thus contributing to the health management and welfare efforts of small apes in captivity.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16439,"journal":{"name":"Journal of Medical Primatology","volume":"54 2","pages":""},"PeriodicalIF":0.8,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143496927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bioconvergence and Non-Human Primate Models in Human Metapneumovirus Research","authors":"Taeho Kwon","doi":"10.1111/jmp.70012","DOIUrl":"https://doi.org/10.1111/jmp.70012","url":null,"abstract":"<div>\u0000 \u0000 <p>Human metapneumovirus (HMPV) poses a significant global health threat. While nonhuman primates (NHPs) remain crucial models, ethical and economic limitations necessitate complementary approaches. Advanced bioconvergence technologies, including organoids, artificial intelligence (AI), and quantum computing, offer scalable, cost-effective, and ethical solutions, enhancing HMPV research, antiviral development, and future clinical applications.</p>\u0000 </div>","PeriodicalId":16439,"journal":{"name":"Journal of Medical Primatology","volume":"54 2","pages":""},"PeriodicalIF":0.8,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143496928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of A Combination of Ketamine and Dexmedetomidine as A Field Anesethetic Protocol for Immobilization of Golden-Mantled Howler Monkeys (Alouatta palliata palliata)","authors":"Shannon B. Nodolf,&nbsp;Joseph A. Smith,&nbsp;Kurt A. Volle,&nbsp;Sofía Bernal-Valle,&nbsp;Maraiah Russell","doi":"10.1111/jmp.70007","DOIUrl":"https://doi.org/10.1111/jmp.70007","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>The golden-mantled howler monkey (<i>Alouatta palliata palliata</i>) is an endangered primate experiencing acute population declines for reasons not fully identified. Health and disease monitoring are critical factors for understanding animal and ecosystem health, yet limited research has been achieved in this species due to difficulties in successful immobilization and sample collection. The purpose of this research is to investigate the efficacy of combined ketamine and dexmedetomidine in providing safe field anesthesia for golden-mantled howler monkeys (<i>A. palliata palliata</i>) to perform physical examinations and biological data collection.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Eighteen free-ranging golden-mantled howler monkeys from the Marino las Baulas National Park in Costa Rica received a remote intramuscular injection of a ketamine-dexmedetomidine combination. Anesthetic timing intervals, cardiorespiratory parameters, and venous blood gases were evaluated.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Successful anesthesia was induced with mean doses of ketamine 8.65 mg/kg (±0.9) and dexmedetomidine 0.043 mg/kg (±0). Recoveries after reversal administration were rapid and smooth, with all animals successfully reintroduced to their colonies within 49 min (mean 38 min) of reversal administration.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Ketamine-dexmedetomidine combination is effective at inducing the appropriate anesthetic plane required for field work in this species and should be considered for in situ capture of free-ranging mantled howler monkeys.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16439,"journal":{"name":"Journal of Medical Primatology","volume":"54 2","pages":""},"PeriodicalIF":0.8,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143489648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Profiling the Gut Microbiome of Hylobatidae and Cercopithecinae: Insights Into the Health of Primates in Captivity","authors":"Roberta Chaya Tawie Tingga,&nbsp;Abd Rahman Mohd-Ridwan,&nbsp;Azroie Denel,&nbsp;Badrul Munir Md-Zain","doi":"10.1111/jmp.70008","DOIUrl":"https://doi.org/10.1111/jmp.70008","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>A healthy gut microbiome is essential for digestion in primates, for developing the gut immune system, and for defense against pathogen invasion. Next-generation sequencing allows for determining the microbiome composition and enables the continuous monitoring of primate health.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>To comprehensively analyze the gut microbiome diversity of three endangered primate species at Matang Wildlife Centre—<i>Hylobates abbotti</i>, <i>Macaca fascicularis</i>, and <i>Macaca nemestrina</i>, using high-throughput sequencing of the 16S rRNA gene.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of 18 phyla, 84 families, 188 genera, and 46 species were successfully classified. <i>H. abbotti</i> exhibited the highest microbial diversity with a distinct microbiome profile from the <i>Macaca</i> species. The presence of <i>Treponema</i> (nonpallidum), <i>Bifidobacterium</i>, and <i>Faecalibacterium prausnitzii</i> is critical for gut health, promoting digestion and maintaining the microbial balance.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>This study highlights the importance of monitoring microbial diversity in captive primates to better understand their health and facilitate the early detection of potential pathogens. This also offers insights into microbiome-based strategies for improving overall animal welfare.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16439,"journal":{"name":"Journal of Medical Primatology","volume":"54 2","pages":""},"PeriodicalIF":0.8,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143481609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determination of Minimum Alveolar Concentrations of Isoflurane and Effective Plasma Concentration of Propofol in Common Marmosets (Callithrix jacchus)","authors":"Kanako Muta,&nbsp;Makoto Koizumi,&nbsp;Takako Miyabe-Nishiwaki,&nbsp;Yusuke Sotomaru,&nbsp;Asako Nobukiyo,&nbsp;Hiroki Ohta,&nbsp;Hirotaka James Okano,&nbsp;Masatoshi Kamata,&nbsp;Dai Nagakubo,&nbsp;Ryohei Nishimura","doi":"10.1111/jmp.70006","DOIUrl":"https://doi.org/10.1111/jmp.70006","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Common marmosets (<i>Callithrix jacchus</i>) have been widely used as laboratory animals; However, limited sedation and anesthetic protocols have yet to be established. In this study, the minimum alveolar concentration of an inhalant (isoflurane) and effective predicted plasma concentration of an injectable anesthetic (propofol) were measured for optimization of sedation and anesthetic protocols in marmosets.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>The minimum alveolar concentrations (MACs) for several stimulations (nociceptive stimulation, endotracheal intubation, and non-painful direct stimulation), MAC-noci, MAC-extb, and MAC-awake, respectively, were measured for isoflurane with the up-and-down method from four healthy marmosets. Predicted plasma concentrations 50 (Cp50s), which are equivalent to MACs of isoflurane, Cp50-noci, Cp50-extb, and Cp50-awake, respectively, were measured for propofol.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>MAC-noci and MAC-extb of isoflurane in marmosets were 1.91% and 1.38%, respectively. MAC-awake was not determined owing to technical difficulties. Cp50-noci, Cp50-extb, and Cp50-awake were 9.45, 7.21, and 3.54 μg/mL, respectively.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The obtained results refined existing isoflurane and propofol for sedation and anesthesia in marmosets.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16439,"journal":{"name":"Journal of Medical Primatology","volume":"54 2","pages":""},"PeriodicalIF":0.8,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jmp.70006","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143446716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preliminary Field-Based Assessment of Disease Symptoms and Physical Wounds in Endangered Shennongjia Golden Snub-Nosed Monkey (Rhinopithecus roxellanahubeiensis) Colonies: Implications for Conservation","authors":"Muhammad Zaman,&nbsp;Fangyi Wei,&nbsp;Mei Chen,&nbsp;Luwei Chen,&nbsp;Hui Yao,&nbsp;Zuofu Xiang","doi":"10.1111/jmp.70003","DOIUrl":"https://doi.org/10.1111/jmp.70003","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Globally, approximately 60% of primate taxa are in danger of extinction and the population of 75% of primate species are declining in their natural habitats. The Endangered <i>R. roxellana hubeiensis</i> monkeys in Shennongjia National Park face threats due to their limited genetic diversity and restricted habitat.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Method</h3>\u0000 \u0000 <p>Our study aimed to assess the health of these monkeys through focal animal sampling observations of 90 individuals from June 2023 to July 2024. Additionally, we compared the prevalence of health concerns on days with and without snow. We identified health issues in 32 individuals (46%), including wounds, signs suggesting disease, and deaths.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Nine lactating females one juvenile and one infant had eye injuries. We noticed three females and one male exhibiting symptoms of eye diseases. We observed that one adult male and three females showed signs of respiratory disease, while three females exhibited signs of skin disease. We found that one adult male and three females indicated signs of respiratory disease and three females showed signs of skin disease. We found that seven monkeys of different ages, including adults, juveniles and infants, died from injuries, diseases and unknown causes. Respiratory and skin disease symptoms were more common on snowy days than on non-snowy days. Additionally, physical and eye injuries were also more prevalent on snowy days.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>In general, our study investigated the health status of Shennongjia golden snub-nosed monkeys and found signs of disease, wounds, and death. Our study also highlighted health issues in monkeys, which can help guide conservation efforts to ensure their survival in their natural habitats.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16439,"journal":{"name":"Journal of Medical Primatology","volume":"54 2","pages":""},"PeriodicalIF":0.8,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143431248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Occurrence of Toxoplasma gondii in Three Tamarin Species (Saguinus geoffroyi, Saguinus oedipus, and Leontocebus fuscicollis) Ex Situ in Colombia","authors":"Karime Angarita-Corzo,&nbsp;Lina M. Henao-Montoya,&nbsp;Mónica Franco-G,&nbsp;Henrique G. Riva,&nbsp;Nathalia M. Correa-Valencia","doi":"10.1111/jmp.70005","DOIUrl":"https://doi.org/10.1111/jmp.70005","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Toxoplasmosis, caused by <i>Toxoplasma gondii</i>, is a zoonotic disease affecting public health and wildlife conservation, including nonhuman primates. This study evaluated the presence of <i>T. gondii</i> in three neotropical tamarin species (<i>Leontocebus fuscicollis, Saguinus geoffroyi</i> and <i>Saguinus oedipus</i>) at Barranquilla Zoo, Colombia.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A retrospective analysis (2017–2022) was conducted on 17 tamarins. Clinical evaluations and blood samples were used to detect IgG antibodies via latex agglutination test. Necropsies and histopathological analyses were used to assess organ lesions associated with <i>T. gondii.</i></p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>In 2017, 35% (6/17) of the participants tested seropositive, increasing to 100% (13/13) by 2022. Antibody titer fluctuations were noted, with significant increases in female <i>S. oedipus</i>. Four deaths occurred, two linked to active or chronic infections. Stray cats and rodents in the zoo were identified as possible transmission vectors.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>This study highlights <i>T. gondii</i> exposure to tamarins, associated mortality, and diagnostic challenges. Recommendations include stray cat management, pest control, and the exploration of vaccines to reduce transmission risks.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16439,"journal":{"name":"Journal of Medical Primatology","volume":"54 2","pages":""},"PeriodicalIF":0.8,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143431247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acute Epididymo-Orchitis Caused by Escherichia coli in a Rhesus Monkey","authors":"Heling Li,&nbsp;Long Zhang,&nbsp;Hong Wang","doi":"10.1111/jmp.70004","DOIUrl":"https://doi.org/10.1111/jmp.70004","url":null,"abstract":"<div>\u0000 \u0000 <p>Epididymo-orchitis is characterized by painful swelling and inflammation of the epididymis and testes. A 4-year-old male rhesus monkey has clinical manifestations including anorexia, weakness, as well as redness and swelling of the right testis and epididymis. Bacterial culture of the urine was positive for <i>Escherichia coli</i>. Due to the antibiotic treatment being ineffective, the animal underwent a right orchiectomy. Postoperative histopathology confirmed necrosis and significant inflammatory cell infiltration, indicating severe acute epididymo-orchitis (EO) caused by <i>E. coli</i> infection in the rhesus monkey. After surgical treatment and postoperative care, the animal survived. To our knowledge, this represents the first report of acute EO caused by <i>E. coli</i> in a rhesus monkey. These findings not only enhance our understanding of EO in NHPs but also provide a reference for further biomedical studies of EO induced by <i>E. coli.</i></p>\u0000 </div>","PeriodicalId":16439,"journal":{"name":"Journal of Medical Primatology","volume":"54 2","pages":""},"PeriodicalIF":0.8,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143439100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}