Age-Related Changes in the Cardiothoracic Ratio of Juvenile Japanese Macaques (Macaca fuscata)

IF 0.5 4区农林科学 Q3 VETERINARY SCIENCES

Journal of Medical Primatology Pub Date : 2025-09-15 DOI:10.1111/jmp.70033

Yuto Sawada, Akihisa Kaneko, Naohide Ageyama, Shinichiro Nakamura, Takako Miyabe-Nishiwaki, Atsushi Tsukamoto

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Abstract

Background

Evaluation of the cardiothoracic ratio (CTR) using chest radiography is a valuable tool for screening cardiac diseases; however, age-related changes in CTR remain unclear, particularly in Japanese macaques. This study assessed the CTR in juvenile Japanese macaques and examined its relationship with age and sex.

Materials and Methods

CTR was calculated from chest radiographs of juvenile macaques aged 1–4 years and compared with those of adults. Correlations between CTR and age in months and differences between sexes were analyzed.

Results

Juvenile macaques showed a significantly higher CTR than adults. A significant negative correlation was observed between age and CTR. No significant sex-related differences in CTR were observed across ages.

Conclusions

The CTR in Japanese macaques decreases with age, indicating that age-specific reference values are essential for accurately assessing cardiac size in juvenile individuals. These findings will contribute to the early detection and management of cardiac diseases in juvenile Japanese macaques.

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幼年日本猕猴心胸比例的年龄相关变化。

背景：胸片评价胸廓比值（CTR）是筛查心脏疾病的一种有价值的工具；然而，与年龄相关的CTR变化仍不清楚，特别是在日本猕猴中。本研究评估了幼年日本猕猴的CTR，并探讨了其与年龄和性别的关系。材料与方法：利用1 ~ 4岁幼年猕猴胸片计算CTR，并与成年猕猴胸片进行比较。分析CTR与月龄、性别差异的相关性。结果：幼年猕猴的CTR明显高于成年猕猴。年龄与CTR呈显著负相关。不同年龄的CTR没有明显的性别差异。结论：日本猕猴的CTR随年龄的增长而降低，表明年龄特异性参考值对于准确评估幼年个体的心脏大小至关重要。这些发现将有助于日本猕猴幼年心脏疾病的早期发现和治疗。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Medical Primatology 生物-动物学

CiteScore

1.40

自引率

42.90%

发文量

审稿时长

6 months

期刊介绍： The Journal of Medical Primatology publishes research on non-human primates as models to study, prevent, and/or treat human diseases; subjects include veterinary medicine; morphology, physiology, reproductive biology, central nervous system, and cardiovascular diseases; husbandry, handling, experimental methodology, and management of non-human primate colonies and laboratories; non-human primate wildlife management; and behaviour and sociology as related to medical conditions and captive non-human primate needs. Published material includes: Original Manuscripts - research results; Case Reports - scientific documentation of a single clinical study; Short Papers - case histories, methodologies, and techniques of particular interest; Letters to the Editor - opinions, controversies and sporadic scientific observations; Perspectives – opinion piece about existing research on a particular topic; Minireviews – a concise review of existing literature; Book Reviews by invitation; Special Issues containing selected papers from specialized meetings; and Editorials and memoriams authored by the Editor-in-Chief.