Journal of Medical Primatology最新文献

{"title":"Housing relocation does not have to induce a significant stress response in captive Japanese macaques (Macaca fuscata)","authors":"Nelson Broche Jr.,&nbsp;Vanessa Gris,&nbsp;Naoko Suda-Hashimoto,&nbsp;Keiko Mouri,&nbsp;Takako Miyabe-Nishiwaki,&nbsp;Juri Suzuki,&nbsp;Michael A. Huffman","doi":"10.1111/jmp.12667","DOIUrl":"10.1111/jmp.12667","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Previous studies suggest that housing relocation may be stressful for captive non-human primates. Our study investigated the stress levels of Japanese macaques during a housing relocation by measuring their daily fecal cortisol metabolites, which are often used as an indicator of stress.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Ten adult Japanese macaques, single-housed for research purposes, were relocated to a new facility. Fecal samples were collected daily for 7 days. Cortisol metabolite concentrations were determined via enzyme immunoassay.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>No significant differences in cortisol metabolite levels were found in 7 days, but concentration levels showed that the highest median was associated to the relocation day.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The minimal cortisol metabolite increase suggests that there was a slight activity increase in the hypothalamic-pituitary-adrenal axis. Techniques encouraging cooperation of the monkeys, the short time duration of the relocation, and consistency in the environment may have contributed to the minimal stress levels observed.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16439,"journal":{"name":"Journal of Medical Primatology","volume":"52 6","pages":"347-352"},"PeriodicalIF":0.7,"publicationDate":"2023-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10268971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Klebsiella pneumoniae infection in cynomolgus monkeys at primate research center facility in Indonesia","authors":"Suryo Saputro,&nbsp;Uus Saepuloh,&nbsp;Huda Shalahudin Darusman,&nbsp;Wahyu Putriyani,&nbsp; Permanawati,&nbsp;Ellis Dwi Ayuningsih,&nbsp;Silvia Arin Prabandari,&nbsp;Dyah Setyawati,&nbsp;Joko Pamungkas","doi":"10.1111/jmp.12665","DOIUrl":"10.1111/jmp.12665","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p><i>Klebsiella pneumoniae</i> infection in nonhuman primates has been widely reported and causes significant morbidity and mortality. Animal deaths occur routinely at the Primate Research Center of IPB University. The results of necropsy and culture suggested a <i>K. pneumoniae</i> infection.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A mass health assessment of Cynomolgus monkeys (<i>n</i> = 429) was carried out by physical examination and molecular targeting <i>K. pneumoniae</i> (<i>n</i> = 96), family of <i>Coronaviridae</i> (<i>n</i> = 148) and <i>Paramyxoviridae</i> (<i>n</i> = 148).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of 49.18% of the animals had clinical symptoms of respiratory disorders, abscesses, trauma, and others. PCR results indicated that 28.57% were positive for <i>K. pneumoniae</i> with 35.71% mortality, while all samples were negative for both virus families.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>There have been outbreaks caused by <i>K. pneumoniae</i> and/or <i>K. pneumoniae subsp. pneumoniae</i>. This disease is chronic, infects all of the buildings, and no tendency for disease transmission according to gender and age class.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16439,"journal":{"name":"Journal of Medical Primatology","volume":"52 6","pages":"361-368"},"PeriodicalIF":0.7,"publicationDate":"2023-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10268968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mediastinal T-cell lymphoma in a free-ranging brown howler monkey (Alouatta guariba clamitans)","authors":"Alex Junior Souza de Souza,&nbsp;Victor Lopes da Silva,&nbsp;Lilian Rose Marques de Sá","doi":"10.1111/jmp.12663","DOIUrl":"10.1111/jmp.12663","url":null,"abstract":"<p>A free-ranging brown howler monkey (Atelidae: <i>Alouatta guariba clamitans</i>) was necropsied and a mediastinal T-cell lymphoma and esophageal dilation were diagnosed. The case report may contribute to the differential diagnosis of neoplastic and esophageal lesions in non-human primates and highlighted the importance of surveillance of cancer in wildlife.</p>","PeriodicalId":16439,"journal":{"name":"Journal of Medical Primatology","volume":"53 1","pages":""},"PeriodicalIF":0.7,"publicationDate":"2023-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9873748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dolichocolon (redundant colon) in a rhesus macaque (Macaca mulatta)","authors":"Diego Celdran-Bonafonte,&nbsp;Kathryn A. O'Connell,&nbsp;Katalin M. Gothard,&nbsp;Iman Ghaderi,&nbsp;David Besselsen,&nbsp;Cynthia J. Doane","doi":"10.1111/jmp.12664","DOIUrl":"10.1111/jmp.12664","url":null,"abstract":"<p>Dolichocolon (redundant colon) is an underdiagnosed cause of severe constipation in humans. The clinical presentation reported here in a rhesus macaque closely resembles that of intestinal adenocarcinoma, the most common neoplasia in macaques. Dolichocolon should be considered in differential diagnosis of macaques with anorexia, weight loss, and constipation.</p>","PeriodicalId":16439,"journal":{"name":"Journal of Medical Primatology","volume":"53 1","pages":""},"PeriodicalIF":0.7,"publicationDate":"2023-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9854166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex-specific differences and predictors of echocardiographic measures of diastolic dysfunction in rhesus macaques (Macaca mulatta)","authors":"Victor N. Rivas,&nbsp;Yu Ueda,&nbsp;Joshua A. Stern","doi":"10.1111/jmp.12662","DOIUrl":"10.1111/jmp.12662","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Diastolic dysfunction in humans is an age-related process with an overrepresentation in women. In rhesus macaques (<i>Macaca mulatta</i>), the incidence and predictors of diastolic dysfunction have yet to be reported.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Data from routine echocardiographic evaluations on clinically healthy rhesus macaques was obtained and used for univariate, bivariate, hypothesis testing, and linear regression statistical analyses interrogating differences and predictors of diastolic function.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Rhesus macaques fully recapitulate previously reported human hemodynamic studies. Female monkeys display impaired diastology and are at an increased risk for developing diastolic dysfunction. Age, sex, and proxies of exercise activity are confirmed predictors for measures of diastolic dysfunction, regardless of specific pathogen-free status.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Rhesus macaques share common sex- and age-related echocardiographic findings as humans, therefore, serve as a valuable translational nonhuman primate model for future studies of diastolic dysfunction. These findings confirm the importance of sex- and age-matching within future rhesus macaque cardiovascular research.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16439,"journal":{"name":"Journal of Medical Primatology","volume":"52 6","pages":"374-383"},"PeriodicalIF":0.7,"publicationDate":"2023-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jmp.12662","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9839294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A pharmacokinetic study of extended-release buprenorphine in cynomolgus monkeys (Macaca fasicularis)","authors":"Hilton Klein,&nbsp;Barry L. Levinson,&nbsp;Steven L. Leary,&nbsp;Glenn Dobson","doi":"10.1111/jmp.12661","DOIUrl":"10.1111/jmp.12661","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>A novel buprenorphine (BUP) extended-release formulation (BUP-XR) produced as a lipid-encapsulated, low viscosity BUP suspension for subcutaneous (SC) injection to control pain was evaluated for pharmacokinetics and safety in four adult male cynomolgus monkeys.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Each animal was given 0.2 mg/kg reformulated BUP-XR SC. Clinical observations were made during the course of the study. Blood samples were obtained from each animal before BUP-XR administration, 6, 24, 48, 72, and 96 h post-BUP-XR injection. Plasma levels of buprenorphine were analyzed using HPLC-MS/MS. The PK values calculated included peak plasma concentration of the BUP analyte, time to peak plasma concentration, plasma half-life, area under the plasma concentration–time curve, clearance, apparent volume of distribution, and elimination rate constant (C_max, T_max, T_½, AUC_0-t, CL, Vd, and Ke, respectively).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Observable adverse clinical signs were not detected. BUP concentration peaked from 6 to 48 h, then declined in a linear fashion. Quantifiable plasma BUP was measured in all monkeys at all time points. Results indicate that a single BUP-XR dose at 0.2 mg/kg can reliably provide plasma levels of BUP reported in the literature to be therapeutically relevant for up to 96 h.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Because of the lack of any clinical observations or adverse effects at the injection site or absence of observable abnormal behaviors, it may be concluded that the use of BUP-XR is safe and efficacious in this species of non-human primate at the dose regimen described in this study for up to 96 h post-administration.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16439,"journal":{"name":"Journal of Medical Primatology","volume":"52 6","pages":"369-373"},"PeriodicalIF":0.7,"publicationDate":"2023-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10126299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Traumatic chylothorax in urbanized free-ranging black-tufted marmosets (Callithrix penicillata)","authors":"Rafaela Magalhães Barros,&nbsp;Isabel Luana de Macêdo,&nbsp;Davi Emanuel Ribeiro de Sousa,&nbsp;Líria Queiroz Luz Hirano,&nbsp;Giane Regina Paludo,&nbsp;Márcio Botelho de Castro","doi":"10.1111/jmp.12660","DOIUrl":"10.1111/jmp.12660","url":null,"abstract":"<p>After fatal traumatic injuries, three urbanized free-ranging marmosets developed a milky white or pink-white thoracic alkaline effusion with high specific gravity, triglyceride levels, and predominance of small lymphocytes. Chylothorax is an uncommon thoracic fluid accumulation in animals and humans and has not been reported in free-ranging non-human primates.</p>","PeriodicalId":16439,"journal":{"name":"Journal of Medical Primatology","volume":"53 1","pages":""},"PeriodicalIF":0.7,"publicationDate":"2023-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9795147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nerve sheath tumor in the forearm of a common marmoset (Callithrix jacchus)","authors":"Sarah Kezar,&nbsp;Natalie W. Fowlkes,&nbsp;Martha E. Hensel","doi":"10.1111/jmp.12659","DOIUrl":"10.1111/jmp.12659","url":null,"abstract":"<p>Tumors of the skin and subcutaneous tissues are uncommon in marmosets. In this report, we describe the gross, histopathology, and immunohistochemical findings of a nerve sheath tumor that arose in the left forearm of an adult female marmoset (<i>Callthrix jacchus</i>).</p>","PeriodicalId":16439,"journal":{"name":"Journal of Medical Primatology","volume":"53 1","pages":""},"PeriodicalIF":0.7,"publicationDate":"2023-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9668719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Successful surgical correction of a cataract in a chimpanzee (Pan troglodytes) via field setting at a zoological facility","authors":"Chelsea E. Anderson,&nbsp;Jonathan H. Tzu,&nbsp;Elizabeth E. Hammond","doi":"10.1111/jmp.12657","DOIUrl":"10.1111/jmp.12657","url":null,"abstract":"<p>A 41-year-old male vasectomized, zoo-housed chimpanzee (<i>Pan troglodytes</i>) presented with progressive visual deficits due to bilateral cataract formation. Phacoemulsification and lenticular implant were performed by a veterinary and human board-certified ophthalmologist team in a field setting. Post-operative healing occurred without complication, and the patient returned to the troop with improved vision.</p>","PeriodicalId":16439,"journal":{"name":"Journal of Medical Primatology","volume":"52 4","pages":"276-278"},"PeriodicalIF":0.7,"publicationDate":"2023-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10154830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Filarial hyperinfection in two neotropical primates from eastern Amazon peri-urban areas","authors":"David F. Conga,&nbsp;Amanda A. Figueiredo,&nbsp;Ana Sílvia S. Ribeiro,&nbsp;Andrea M. Bezerra,&nbsp;Washington L. A. Pereira","doi":"10.1111/jmp.12658","DOIUrl":"10.1111/jmp.12658","url":null,"abstract":"<p>We report two cases of disseminated hyperinfection by filariae in free-living primates <i>Saimiri sciureus</i> and <i>Saguinus niger</i> from eastern Amazon. Histopathological examination showed the presence of <i>Dipetalonema gracile</i> microfilariae in blood, liver, lungs, spleen, small intestine, kidney, brain, liver, and adults in peritoneal thoracic cavity.</p>","PeriodicalId":16439,"journal":{"name":"Journal of Medical Primatology","volume":"52 4","pages":"272-275"},"PeriodicalIF":0.7,"publicationDate":"2023-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9795617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}