Journal of Medical Primatology最新文献

{"title":"Viral evolution of SIV chimpanzee toward HIV-1 using humanized mice","authors":"James Z. Curlin,&nbsp;Kimberly Schmitt,&nbsp;Leila Remling-Mulder,&nbsp;Corina Valencia Tibbitts,&nbsp;Shelby O'Connor,&nbsp;Preston Marx,&nbsp;Ramesh Akkina","doi":"10.1111/jmp.12675","DOIUrl":"10.1111/jmp.12675","url":null,"abstract":"<p>HIV-1 emerged from SIVcpz evolving in humans. Humanized mice are an effective tool for assessing viral evolution via measuring viral loads, CD4⁺ T cell decline, and analyzing genetic changes. Four serial passages showed many non-synonymous mutations important for the adaptation and evolution of SIVcpz to human immune cells.</p>","PeriodicalId":16439,"journal":{"name":"Journal of Medical Primatology","volume":"52 5","pages":"294-297"},"PeriodicalIF":0.7,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jmp.12675","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10305370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterizing the phenotypic and genetic changes of pre-epidemic HIV-2 group F virus following serial passage in humanized mice","authors":"James Z. Curlin,&nbsp;Kimberly Schmitt,&nbsp;Leila Remling-Mulder,&nbsp;Corina Valencia Tibbitts,&nbsp;Shelby O'Connor,&nbsp;Preston Marx,&nbsp;Ramesh Akkina","doi":"10.1111/jmp.12674","DOIUrl":"10.1111/jmp.12674","url":null,"abstract":"<p>HIV-2 Group F virus with an origin in NHPs was isolated from only two individuals. Two serial passages in hu-mice showed increased viral loads, CD4⁺ T cell decline and nonsynonymous genetic changes showing its capacity for further evolution, and spread in the human.</p>","PeriodicalId":16439,"journal":{"name":"Journal of Medical Primatology","volume":"52 5","pages":"290-293"},"PeriodicalIF":0.7,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jmp.12674","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10652354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"First report of spontaneous hepatic fibrosarcoma in a white-tufted marmoset (Callithrix jacchus) kept in captivity","authors":"Soraya Kezam Malaga,&nbsp;Melina Castilho de Souza Balbueno,&nbsp;Jéssica Amâncio Martins,&nbsp;Leonardo Dourado da Costa,&nbsp;Maria Luiza de Sousa Barbosa,&nbsp;Cidéli de Paula Coelho","doi":"10.1111/jmp.12671","DOIUrl":"10.1111/jmp.12671","url":null,"abstract":"<p>Reports of sarcomas in nonhuman primates are scarce and, specifically, primary hepatic sarcomas are rare, as in humans. This is the first report of an aggressive hepatic fibrosarcoma in a young adult <i>Callithrix jacchus.</i> The final postmortem diagnosis was obtained by means of immunohistochemical analysis, which confirmed the tumor histogenesis.</p>","PeriodicalId":16439,"journal":{"name":"Journal of Medical Primatology","volume":"53 1","pages":""},"PeriodicalIF":0.7,"publicationDate":"2023-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10110462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quality of hematology and clinical chemistry results in laboratory and zoo nonhuman primates: Effects of the preanalytical phase. A review","authors":"Fanny A. Granat,&nbsp;Catherine Trumel,&nbsp;Jean-Pierre D. Braun,&nbsp;Nathalie H. Bourgès-Abella","doi":"10.1111/jmp.12666","DOIUrl":"10.1111/jmp.12666","url":null,"abstract":"<p>Most errors in clinical pathology originate in the preanalytical phase, which includes all steps from the preparation of animals and equipment to the collection of the specimen and its management until analyzed. Blood is the most common specimen collected in nonhuman primates. Other specimens collected include urine, saliva, feces, and hair. The primary concern is the variability of blood hematology and biochemistry results due to sampling conditions with the effects of capture, restraint, and/or anesthesia. Housing and diet have fewer effects, with the exception of food restriction to reduce obesity. There has been less investigation regarding the impact of sampling conditions of nonblood specimens.</p>","PeriodicalId":16439,"journal":{"name":"Journal of Medical Primatology","volume":"52 6","pages":"414-427"},"PeriodicalIF":0.7,"publicationDate":"2023-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jmp.12666","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10060378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fatal Simplexvirus humanalpha1 infection in howler-monkeys (Alouatta sp.) under human care: Clinical, molecular, and pathological findings","authors":"Joanna V. Z. Echenique,&nbsp;Anderson H. Gris,&nbsp;Laura J. Camargo,&nbsp;Cíntia De Lorenzo,&nbsp;Marianna Bertolini,&nbsp;Franscisca M. S. Barbosa,&nbsp;Moira Ansolch,&nbsp;Cláudio W. Canal,&nbsp;Welden Panziera,&nbsp;Saulo P. Pavarini,&nbsp;Luciana Sonne","doi":"10.1111/jmp.12670","DOIUrl":"10.1111/jmp.12670","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p><i>Simplexvirus humanalpha1</i> (HuAHV-1) are common anthropozoonosis reported in marmosets but rare in howler monkeys (<i>Alouatta</i> sp.).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Necropsy of two brown-howler monkeys (<i>A. caraya</i>) and one red-howler monkey (<i>A. guariba clamitans</i>) from different zoo collections were performed. Fragments of all organs were examined through microscopy. Samples were submitted to IHC for <i>Simplexvirus humanalpha 2</i> (HuAHV-2) [sin. Herpesvirus simplex type 2] and PCR.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Grossly, only the <i>A. guariba</i> showed liver lesions characterized by multifocal, pinpoint white areas corresponding microscopically as random necrotizing herpetic hepatitis and ulcerative glossitis. Both <i>A. caraya</i> showed necrotizing meningoencephalitis with Cowdry A-type body inclusions within neurons and astrocytes. Immunolabeling for HuAHV-1/2 was observed in the tongue, liver, and brain. HuAHV-1 was confirmed in all samples by PCR, Sanger sequencing, and phylogenetic analyses.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Necrotizing meningoencephalitis was appreciated in 2/3 of animals, and it is associated with neurologic signs. Along with ulcerative glossitis, a hallmark lesion in marmosets, it was present in one animal. Regarding herpetic hepatitis, it is not frequent in monkeys and occurs mainly in immunocompromised animals. HuAHV-1 infection was confirmed corroborating with a human source. This is the second report on captive black-howler monkeys and the first gross, histologic, immunohistochemical, and molecular description of herpetic hepatitis and ulcerative glossitis in red-howler monkeys (<i>A. guariba</i>).</p>\u0000 </section>\u0000 </div>","PeriodicalId":16439,"journal":{"name":"Journal of Medical Primatology","volume":"52 6","pages":"392-399"},"PeriodicalIF":0.7,"publicationDate":"2023-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10032501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clostridium ventriculi in a cynomolgus monkey with acute gastric dilatation and rupture: A case report","authors":"Gyu-Seo Bae,&nbsp;Eun-Su Jeon,&nbsp;Hee Chang Son,&nbsp;Philyong Kang,&nbsp;Kyung Seob Lim,&nbsp;Eun-Ha Hwang,&nbsp;Green Kim,&nbsp;Seung Ho Baek,&nbsp;You Jung An,&nbsp;Gyu Young Shim,&nbsp;Young Min Woo,&nbsp;YuJin Kim,&nbsp;Taehwan Oh,&nbsp;Seok-Hwan Kim,&nbsp;JungJoo Hong,&nbsp;Bon-Sang Koo","doi":"10.1111/jmp.12668","DOIUrl":"10.1111/jmp.12668","url":null,"abstract":"<p>Acute gastric dilatation (AGD) is one of the most prevalent and life-threatening diseases in nonhuman primates worldwide. However, the etiology of this syndrome has not been determined. Recently, sudden death occurred in a 7-year-old female cynomolgus monkey with a history of fecal microbiota transplantation using diarrheic stools. The monkey had undergone surgery previously. On necropsy, gastric dilatation and rupture demonstrated a tetrad arrangement on histopathologic examination. On 16S rRNA sequencing, a high population of <i>Clostridium ventriculi</i> was identified in the duodenum adjacent to stomach but not in the colon. This paper is the first report of <i>Clostridium ventriculi</i> infection in a cynomolgus macaque with acute gastric dilatation and rupture.</p>","PeriodicalId":16439,"journal":{"name":"Journal of Medical Primatology","volume":"53 1","pages":""},"PeriodicalIF":0.7,"publicationDate":"2023-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jmp.12668","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10359413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Housing relocation does not have to induce a significant stress response in captive Japanese macaques (Macaca fuscata)","authors":"Nelson Broche Jr.,&nbsp;Vanessa Gris,&nbsp;Naoko Suda-Hashimoto,&nbsp;Keiko Mouri,&nbsp;Takako Miyabe-Nishiwaki,&nbsp;Juri Suzuki,&nbsp;Michael A. Huffman","doi":"10.1111/jmp.12667","DOIUrl":"10.1111/jmp.12667","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Previous studies suggest that housing relocation may be stressful for captive non-human primates. Our study investigated the stress levels of Japanese macaques during a housing relocation by measuring their daily fecal cortisol metabolites, which are often used as an indicator of stress.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Ten adult Japanese macaques, single-housed for research purposes, were relocated to a new facility. Fecal samples were collected daily for 7 days. Cortisol metabolite concentrations were determined via enzyme immunoassay.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>No significant differences in cortisol metabolite levels were found in 7 days, but concentration levels showed that the highest median was associated to the relocation day.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The minimal cortisol metabolite increase suggests that there was a slight activity increase in the hypothalamic-pituitary-adrenal axis. Techniques encouraging cooperation of the monkeys, the short time duration of the relocation, and consistency in the environment may have contributed to the minimal stress levels observed.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16439,"journal":{"name":"Journal of Medical Primatology","volume":"52 6","pages":"347-352"},"PeriodicalIF":0.7,"publicationDate":"2023-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10268971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Klebsiella pneumoniae infection in cynomolgus monkeys at primate research center facility in Indonesia","authors":"Suryo Saputro,&nbsp;Uus Saepuloh,&nbsp;Huda Shalahudin Darusman,&nbsp;Wahyu Putriyani,&nbsp; Permanawati,&nbsp;Ellis Dwi Ayuningsih,&nbsp;Silvia Arin Prabandari,&nbsp;Dyah Setyawati,&nbsp;Joko Pamungkas","doi":"10.1111/jmp.12665","DOIUrl":"10.1111/jmp.12665","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p><i>Klebsiella pneumoniae</i> infection in nonhuman primates has been widely reported and causes significant morbidity and mortality. Animal deaths occur routinely at the Primate Research Center of IPB University. The results of necropsy and culture suggested a <i>K. pneumoniae</i> infection.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A mass health assessment of Cynomolgus monkeys (<i>n</i> = 429) was carried out by physical examination and molecular targeting <i>K. pneumoniae</i> (<i>n</i> = 96), family of <i>Coronaviridae</i> (<i>n</i> = 148) and <i>Paramyxoviridae</i> (<i>n</i> = 148).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of 49.18% of the animals had clinical symptoms of respiratory disorders, abscesses, trauma, and others. PCR results indicated that 28.57% were positive for <i>K. pneumoniae</i> with 35.71% mortality, while all samples were negative for both virus families.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>There have been outbreaks caused by <i>K. pneumoniae</i> and/or <i>K. pneumoniae subsp. pneumoniae</i>. This disease is chronic, infects all of the buildings, and no tendency for disease transmission according to gender and age class.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16439,"journal":{"name":"Journal of Medical Primatology","volume":"52 6","pages":"361-368"},"PeriodicalIF":0.7,"publicationDate":"2023-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10268968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mediastinal T-cell lymphoma in a free-ranging brown howler monkey (Alouatta guariba clamitans)","authors":"Alex Junior Souza de Souza,&nbsp;Victor Lopes da Silva,&nbsp;Lilian Rose Marques de Sá","doi":"10.1111/jmp.12663","DOIUrl":"10.1111/jmp.12663","url":null,"abstract":"<p>A free-ranging brown howler monkey (Atelidae: <i>Alouatta guariba clamitans</i>) was necropsied and a mediastinal T-cell lymphoma and esophageal dilation were diagnosed. The case report may contribute to the differential diagnosis of neoplastic and esophageal lesions in non-human primates and highlighted the importance of surveillance of cancer in wildlife.</p>","PeriodicalId":16439,"journal":{"name":"Journal of Medical Primatology","volume":"53 1","pages":""},"PeriodicalIF":0.7,"publicationDate":"2023-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9873748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dolichocolon (redundant colon) in a rhesus macaque (Macaca mulatta)","authors":"Diego Celdran-Bonafonte,&nbsp;Kathryn A. O'Connell,&nbsp;Katalin M. Gothard,&nbsp;Iman Ghaderi,&nbsp;David Besselsen,&nbsp;Cynthia J. Doane","doi":"10.1111/jmp.12664","DOIUrl":"10.1111/jmp.12664","url":null,"abstract":"<p>Dolichocolon (redundant colon) is an underdiagnosed cause of severe constipation in humans. The clinical presentation reported here in a rhesus macaque closely resembles that of intestinal adenocarcinoma, the most common neoplasia in macaques. Dolichocolon should be considered in differential diagnosis of macaques with anorexia, weight loss, and constipation.</p>","PeriodicalId":16439,"journal":{"name":"Journal of Medical Primatology","volume":"53 1","pages":""},"PeriodicalIF":0.7,"publicationDate":"2023-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9854166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}