Journal of Medical Primatology最新文献

{"title":"Nerve sheath tumor in the forearm of a common marmoset (Callithrix jacchus)","authors":"Sarah Kezar,&nbsp;Natalie W. Fowlkes,&nbsp;Martha E. Hensel","doi":"10.1111/jmp.12659","DOIUrl":"10.1111/jmp.12659","url":null,"abstract":"<p>Tumors of the skin and subcutaneous tissues are uncommon in marmosets. In this report, we describe the gross, histopathology, and immunohistochemical findings of a nerve sheath tumor that arose in the left forearm of an adult female marmoset (<i>Callthrix jacchus</i>).</p>","PeriodicalId":16439,"journal":{"name":"Journal of Medical Primatology","volume":"53 1","pages":""},"PeriodicalIF":0.7,"publicationDate":"2023-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9668719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Successful surgical correction of a cataract in a chimpanzee (Pan troglodytes) via field setting at a zoological facility","authors":"Chelsea E. Anderson,&nbsp;Jonathan H. Tzu,&nbsp;Elizabeth E. Hammond","doi":"10.1111/jmp.12657","DOIUrl":"10.1111/jmp.12657","url":null,"abstract":"<p>A 41-year-old male vasectomized, zoo-housed chimpanzee (<i>Pan troglodytes</i>) presented with progressive visual deficits due to bilateral cataract formation. Phacoemulsification and lenticular implant were performed by a veterinary and human board-certified ophthalmologist team in a field setting. Post-operative healing occurred without complication, and the patient returned to the troop with improved vision.</p>","PeriodicalId":16439,"journal":{"name":"Journal of Medical Primatology","volume":"52 4","pages":"276-278"},"PeriodicalIF":0.7,"publicationDate":"2023-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10154830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Filarial hyperinfection in two neotropical primates from eastern Amazon peri-urban areas","authors":"David F. Conga,&nbsp;Amanda A. Figueiredo,&nbsp;Ana Sílvia S. Ribeiro,&nbsp;Andrea M. Bezerra,&nbsp;Washington L. A. Pereira","doi":"10.1111/jmp.12658","DOIUrl":"10.1111/jmp.12658","url":null,"abstract":"<p>We report two cases of disseminated hyperinfection by filariae in free-living primates <i>Saimiri sciureus</i> and <i>Saguinus niger</i> from eastern Amazon. Histopathological examination showed the presence of <i>Dipetalonema gracile</i> microfilariae in blood, liver, lungs, spleen, small intestine, kidney, brain, liver, and adults in peritoneal thoracic cavity.</p>","PeriodicalId":16439,"journal":{"name":"Journal of Medical Primatology","volume":"52 4","pages":"272-275"},"PeriodicalIF":0.7,"publicationDate":"2023-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9795617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Kidney cell culture Macaca fascicularis as a candidate for vaccine development and in vitro model","authors":"Rahmat Yusni,&nbsp;Silmi Mariya,&nbsp;Uus Saepuloh,&nbsp;Sela S. Mariya,&nbsp;Huda S. Darusman","doi":"10.1111/jmp.12655","DOIUrl":"10.1111/jmp.12655","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Cell culture is the proliferation of a cell population in vitro by isolating from the original tissue or growing from existing ones. One essential source is the monkey kidney cell cultures which have an essential role in biomedical study. This is due to the significant homology between the human and macaque genomes making these useful for cultivating human viruses, especially enteroviruses, and growing vaccines.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This study developed cell cultures derived from the kidney of <i>Macaca fascicularis</i> (<i>Mf</i>) and validated its gene expression.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The primary cultures were successfully subcultured up to six passages, grew as monolayers, and exhibited epithelial-like morphology. The cultured cells remained heterogeneous in phenotype and they expressed CD155 and CD46 as viral receptors, cell morphology (CD24, endosialin, and vWF), proliferation, also apoptosis markers (Ki67 and p53).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>These results indicated that the cell cultures can be used as in vitro model cells for vaccine development and bioactive compound.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16439,"journal":{"name":"Journal of Medical Primatology","volume":"52 4","pages":"213-222"},"PeriodicalIF":0.7,"publicationDate":"2023-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9799699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Radiographic measurements of the hind limbs in capuchin monkeys (Sapajus spp.)","authors":"Rafael H. de Souza Siragusi,&nbsp;Sheila C. Rahal,&nbsp;Anneke Moresco,&nbsp;Jeana P. da Silva,&nbsp;Maria J. Mamprim,&nbsp;Eduardo B. Mayrink Cardoso","doi":"10.1111/jmp.12654","DOIUrl":"10.1111/jmp.12654","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Radiographic measurements are a useful tool to assess skeletal health and development in primates. This study aimed to perform radiographic measurements of hind limbs in capuchin monkeys.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Twelve <i>Sapajus</i> spp. were used; ten adults and two sub-adults, nine females and three males.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results and conclusions</h3>\u0000 \u0000 <p>The pelvimetry showed that the pelvic inlet area presented mean values of 7.63, 10.23, and 5.43 cm² for adult males, adult females, and sub-adult females, respectively. The mean inclination angle was 129.45° and the mean values for the mechanical lateral proximal and distal femoral angles were 102.32° and 90.93°, respectively. The mean values for the anatomic lateral proximal and distal femoral angles were 104.59° and 85.98°, respectively. In conclusion, the radiographic measurements proved feasible for hind limb evaluation in <i>Sapajus</i> spp. and can be used for comparison with animals presenting orthopedic lesions.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16439,"journal":{"name":"Journal of Medical Primatology","volume":"52 4","pages":"223-229"},"PeriodicalIF":0.7,"publicationDate":"2023-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9787025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Regulatory pathway underpinning the development of encephalitis after simian immunodeficiency virus infection in rhesus macaques (Macaca mulatta)","authors":"Taeho Kwon,&nbsp;Hong-Yi Xiang,&nbsp;Xiao-Ya Xing,&nbsp;Peng Jiang,&nbsp;Shuai-Yang Sun,&nbsp;Hu-Nan Sun,&nbsp;Ying-Hao Han","doi":"10.1111/jmp.12656","DOIUrl":"10.1111/jmp.12656","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Simian immunodeficiency virus (SIV) infection in rhesus macaques (<i>Macaca mulatta</i>) can lead to the development of SIV encephalitis (SIVE), which is closely related to human immunodeficiency virus (HIV)-induced dementia.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This was done by analyzing SIV and SIVE encephalitis in infected <i>M. mulatta</i> hippocampus samples from two microarray data sets, identifying two groups of common differentially expressed genes and predicting associated protein interactions.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>We found that eight genes—<i>MX1</i>, <i>B2M</i>, <i>IFIT1</i>, <i>TYMP</i>, <i>STAT1</i>, <i>IFI44</i>, <i>ISG15</i>, and <i>IFI27</i>—affected the negative regulation of biological processes, hepatitis C and Epstein–Barr viral infection, and the toll-like receptor signaling pathway, which mediate the development of encephalitis after SIV infection. In particular, <i>STAT1</i> played a central role in the process by regulating biopathological changes during the development of SIVE.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>These findings provide a new theoretical basis for the treatment of encephalopathy after HIV infection by targeting <i>STAT1</i>.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16439,"journal":{"name":"Journal of Medical Primatology","volume":"52 4","pages":"259-271"},"PeriodicalIF":0.7,"publicationDate":"2023-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jmp.12656","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9796016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Avascular necrosis of the femoral head in a cynomolgus macaque (Macaca fascicularis)","authors":"Jeffrey S. Frankel,&nbsp;Kristin L. Gardiner,&nbsp;Angela K. Brice,&nbsp;Lisa Hagan,&nbsp;Timothy J. Manzi,&nbsp;Leah Makaron","doi":"10.1111/jmp.12653","DOIUrl":"10.1111/jmp.12653","url":null,"abstract":"<p>A cynomolgus macaque presented with right hindlimb lameness as well as crepitus and decreased passive range of motion of the right coxal joint. Radiography and histopathology were consistent with avascular necrosis of the femoral head. This case is the first published report of this condition in a cynomolgus macaque.</p>","PeriodicalId":16439,"journal":{"name":"Journal of Medical Primatology","volume":"52 4","pages":"283-285"},"PeriodicalIF":0.7,"publicationDate":"2023-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9792249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chylothorax associated with pulmonary compressive atelectasis in an emperor tamarin (Saguinus imperator)","authors":"Clarissa Helena Santana,&nbsp;Laice Alves da Silva,&nbsp;Nayara Ferreira de Paula,&nbsp;Lucas dos Reis de Souza,&nbsp;Ayisa Rodrigues Oliveira,&nbsp;Daniel Oliveira dos Santos,&nbsp;Herlandes Penha Tinoco,&nbsp;Carlyle Mendes Coelho,&nbsp;Ângela Tinoco Pessanha Ribeiro Gonçalves,&nbsp;Rodrigo Otávio Silveira Silva,&nbsp;Tatiane Alves da Paixão,&nbsp;Renato Lima Santos","doi":"10.1111/jmp.12646","DOIUrl":"10.1111/jmp.12646","url":null,"abstract":"<p>Chylothorax is the accumulation of lymph in the thoracic cavity, and it has never been reported in neotropical primates. An emperor tamarin died and at necropsy chylothorax associated with pulmonary compressive atelectasis was diagnosed. Idiopathic chylothorax can be a cause of respiratory insufficiency and death in tamarins.</p>","PeriodicalId":16439,"journal":{"name":"Journal of Medical Primatology","volume":"52 4","pages":"279-282"},"PeriodicalIF":0.7,"publicationDate":"2023-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9791099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical and histopathological investigation of symmetrical alopecia with associated chronic pruritus in tufted capuchin monkeys (Sapajus apella apella)","authors":"Ana Petak,&nbsp;Jadranko Boras,&nbsp;Ingeborg Bata,&nbsp;Ivana Ilić,&nbsp;Marko Hohšteter,&nbsp;Ivan-Conrado Šoštarić-Zuckermann","doi":"10.1111/jmp.12645","DOIUrl":"10.1111/jmp.12645","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Symmetrical alopecia is a common symptom of endocrine and autoimmune diseases, which are rarely manifested with pruritus. Increased levels of stress in primates have been presented with increased levels of pruritus and alopecia appearance.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A pruritic and alopecic disease was investigated in a group of tufted capuchin monkeys (<i>N</i> = 12), but due to ethical reasons, four random animals were further investigated by numerous diagnostic methods. The impact of food and enclosure enrichment was assessed and observed over a 2-year period.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Histopathology of four random tufted capuchin monkeys revealed lymphocytic perifolliculitis, with an appearance of a “swarm of bees” which was suggestive of alopecia areata. Etiological classification of pruritus excluded dermatological, systemic, and neurological causes, making it behavioral. Enclosure and food enrichment had a beneficial impact on pruritus (12/12) and alopecia (10/12).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The findings were suggestive of alopecia areata, while the pruritus was considered behavioral in origin. Alopecia and pruritus improved upon enclosure and food enrichment.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16439,"journal":{"name":"Journal of Medical Primatology","volume":"52 4","pages":"244-258"},"PeriodicalIF":0.7,"publicationDate":"2023-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9791100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hypercholesterolemia induced by spontaneous oligogenic mutations in rhesus macaques (Macaca mulatta)","authors":"Akiko Takenaka,&nbsp;Juri Suzuki,&nbsp;Hiroyuki Tanaka,&nbsp;Kumiko Hibino,&nbsp;Yoshiro Kamanaka,&nbsp;Shin Nakamura,&nbsp;Fusako Mitsunaga,&nbsp;Yoshi Kawamoto,&nbsp;Mayumi Morimoto,&nbsp;Seitaro Aisu,&nbsp;Takayoshi Natsume","doi":"10.1111/jmp.12642","DOIUrl":"10.1111/jmp.12642","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>A rhesus macaque with the fourth highest plasma cholesterol (CH) levels of 501 breeding macaques was identified 22 years ago. Seven offspring with gene mutations causing hypercholesterolemia were obtained.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Activity of low-density lipoprotein receptor (LDLR), plasma CH levels and mRNA expression levels of <i>LDLR</i> were measured after administration of 0.1% (0.27 mg/kcal) or 0.3% CH.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Activity of <i>p</i>. (<i>Cys82Tyr</i>) of LDLR was 71% and 42% in the heterozygotes and a homozygote, respectively. The mRNA expression level of <i>LDLR</i> in the <i>p</i>. (<i>Val241Ile</i>) of membrane-bound transcription factor protease, site 2 (<i>MBTPS2</i>, S2P protein) was 0.83 times lower than normal levels. <i>LDLR</i> mRNA levels were increased for up to 4 weeks by administration of 0.3% CH before suddenly decreasing to 80% of the baseline levels after 6 weeks.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Oligogenic mutations of <i>p</i>. (<i>Cys82Tyr</i>) in <i>LDLR</i> and <i>p</i>. (<i>Val241Ile</i>) in <i>MBTPS2</i> (S2P) caused hypercholesterolemia exceeding cardiovascular risk levels under a 0.1% CH diet.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16439,"journal":{"name":"Journal of Medical Primatology","volume":"52 4","pages":"230-243"},"PeriodicalIF":0.7,"publicationDate":"2023-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jmp.12642","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9792664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}