Effects of atipamezole on selected physiologic parameters in cynomolgus macaques (Macaca fascicularis)

IF 0.8 4区农林科学 Q3 VETERINARY SCIENCES

Journal of Medical Primatology Pub Date : 2023-10-31 DOI:10.1111/jmp.12682

K. Schwartz, M. Zhang, B. Franco, K. Jampachaisri, R. M. Cotton, M. K. Huss, K. M. Fisher, C. Darian-Smith, P. Sharp, L. Pablo, C. Pacharinsak

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Abstract

Background

Atipamezole, an α-2 adrenergic receptor antagonist, reverses the α-2 agonist anesthetic effects. There is a dearth of information on the physiological effects of these drugs in cynomolgus macaques (Macaca fascicularis). We assessed atipamezole's physiologic effects. We hypothesized atipamezole administration would alter anesthetic parameters.

Methods

Five cynomolgus macaques were sedated with ketamine/dexmedetomidine intramuscularly, followed 45 min later with atipamezole (0.5 mg/kg). Anesthetic parameters (heart rate, blood pressure [systolic (SAP), diastolic (DAP), and mean (MAP) blood pressure], body temperature, respiratory rate, and %SpO2) were monitored prior to and every 10 min (through 60 min) post atipamezole injection.

Results

While heart rate was significantly increased for 60 min; SAP, DAP, MAP, and temperature were significantly decreased at 10 min.

Conclusions

This study indicates subcutaneous atipamezole results in increased heart rate and transient blood pressure decrease. These findings are clinically important to ensure anesthetist awareness to properly support and treat patients as needed.

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阿替帕美唑对食蟹猴选定生理参数的影响。

背景：阿替美唑是一种α-2肾上腺素受体拮抗剂，可逆转α-2激动剂的麻醉作用。关于这些药物对食蟹猴的生理作用，目前还缺乏相关信息。我们评估了阿替帕美唑的生理作用。我们假设阿替帕美唑给药会改变麻醉参数。方法：用氯胺酮/右美托咪定对5只食蟹猕猴进行肌肉注射，45只分钟后使用阿替帕美唑（0.5 mg/kg）。麻醉参数（心率、血压[收缩压（SAP）、舒张压（DAP）和平均血压（MAP）]、体温、呼吸频率和%SpO2）在10 最小值（到60 min）注射后。结果：心率在60 min；SAP、DAP、MAP和温度在10 结论：本研究表明皮下注射阿替帕美唑可使心率加快，血压短暂下降。这些发现对于确保麻醉师意识到根据需要适当支持和治疗患者具有重要临床意义。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Medical Primatology 生物-动物学

CiteScore

1.40

自引率

42.90%

发文量

审稿时长

6 months

期刊介绍： The Journal of Medical Primatology publishes research on non-human primates as models to study, prevent, and/or treat human diseases; subjects include veterinary medicine; morphology, physiology, reproductive biology, central nervous system, and cardiovascular diseases; husbandry, handling, experimental methodology, and management of non-human primate colonies and laboratories; non-human primate wildlife management; and behaviour and sociology as related to medical conditions and captive non-human primate needs. Published material includes: Original Manuscripts - research results; Case Reports - scientific documentation of a single clinical study; Short Papers - case histories, methodologies, and techniques of particular interest; Letters to the Editor - opinions, controversies and sporadic scientific observations; Perspectives – opinion piece about existing research on a particular topic; Minireviews – a concise review of existing literature; Book Reviews by invitation; Special Issues containing selected papers from specialized meetings; and Editorials and memoriams authored by the Editor-in-Chief.