使用人源化小鼠的SIV黑猩猩向HIV-1的病毒进化。

IF 0.8 4区农林科学 Q3 VETERINARY SCIENCES

Journal of Medical Primatology Pub Date : 2023-09-01 DOI:10.1111/jmp.12675

James Z. Curlin, Kimberly Schmitt, Leila Remling-Mulder, Corina Valencia Tibbitts, Shelby O'Connor, Preston Marx, Ramesh Akkina

引用次数: 0

摘要

HIV-1是由在人类中进化的SIVcpz产生的。人源化小鼠是通过测量病毒载量、CD4+T细胞下降和分析基因变化来评估病毒进化的有效工具。四个连续传代显示了许多对SIVcpz对人类免疫细胞的适应和进化很重要的非同义突变。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Viral evolution of SIV chimpanzee toward HIV-1 using humanized mice

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Viral evolution of SIV chimpanzee toward HIV-1 using humanized mice

HIV-1 emerged from SIVcpz evolving in humans. Humanized mice are an effective tool for assessing viral evolution via measuring viral loads, CD4⁺ T cell decline, and analyzing genetic changes. Four serial passages showed many non-synonymous mutations important for the adaptation and evolution of SIVcpz to human immune cells.

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来源期刊

Journal of Medical Primatology 生物-动物学

CiteScore

1.40

自引率

42.90%

发文量

审稿时长

6 months

期刊介绍： The Journal of Medical Primatology publishes research on non-human primates as models to study, prevent, and/or treat human diseases; subjects include veterinary medicine; morphology, physiology, reproductive biology, central nervous system, and cardiovascular diseases; husbandry, handling, experimental methodology, and management of non-human primate colonies and laboratories; non-human primate wildlife management; and behaviour and sociology as related to medical conditions and captive non-human primate needs. Published material includes: Original Manuscripts - research results; Case Reports - scientific documentation of a single clinical study; Short Papers - case histories, methodologies, and techniques of particular interest; Letters to the Editor - opinions, controversies and sporadic scientific observations; Perspectives – opinion piece about existing research on a particular topic; Minireviews – a concise review of existing literature; Book Reviews by invitation; Special Issues containing selected papers from specialized meetings; and Editorials and memoriams authored by the Editor-in-Chief.