Journal of Medical Primatology最新文献

{"title":"Simian retrovirus transmission in rhesus macaques","authors":"Peter Nham,&nbsp;Bryson Halley,&nbsp;Koen K. A. Van Rompay,&nbsp;Jeffrey Roberts,&nbsp;JoAnn Yee","doi":"10.1111/jmp.12726","DOIUrl":"10.1111/jmp.12726","url":null,"abstract":"<p>Historically, to generate Simian Retrovirus (SRV) positive control materials, we performed in vivo passage by inoculating uninfected rhesus macaques with whole blood from an SRV-1 infected (antibody and PCR positive) macaque. However, recent attempts using this approach have failed. This study reports observations and explores why it has become more difficult to transmit SRV via in vivo passage.</p>","PeriodicalId":16439,"journal":{"name":"Journal of Medical Primatology","volume":"53 4","pages":""},"PeriodicalIF":0.8,"publicationDate":"2024-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141788400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Age and sex associated organ weight differences in vervets/African green monkeys (Chlorocebus aethiops sabaeus)","authors":"Gayathriy Balamayooran,&nbsp;Janet A. Tooze,&nbsp;Jean F. Gardin,&nbsp;Margaret C. Long,&nbsp;David L. Caudell,&nbsp;J. Mark Cline,&nbsp;Nancy D. Kock,&nbsp;Monica Paitsel,&nbsp;Stacy Moore,&nbsp;Matthew J. Jorgensen","doi":"10.1111/jmp.12721","DOIUrl":"10.1111/jmp.12721","url":null,"abstract":"&lt;p&gt;Nonhuman primates are crucial biomedical research models, intermediate between rodents and humans. AGMs have been utilized in a variety of research studies for many years.&lt;span&gt;&lt;sup&gt;1-3&lt;/sup&gt;&lt;/span&gt; These primates have similar behavior and physiology&lt;span&gt;&lt;sup&gt;1&lt;/sup&gt;&lt;/span&gt; to that of other Old-World primates used in biomedical research and are useful alternatives to Asian species, such as rhesus and cynomolgus macaques. AGMs are phylogenetically similar to other laboratory primates as well as to humans. Furthermore, AGMs are highly adaptable, less expensive than macaques, and are safer to work with for humans since they are not carriers of macacine herpesvirus 1.&lt;/p&gt;&lt;p&gt;AGMs have been used in a wide variety of biomedical studies including infectious disease, diabetes/metabolism, behavior, aging/Alzheimer's disease, toxicity and medical device testing.&lt;span&gt;&lt;sup&gt;4&lt;/sup&gt;&lt;/span&gt; Infectious diseases,&lt;span&gt;&lt;sup&gt;5-9&lt;/sup&gt;&lt;/span&gt; metabolic disorders,&lt;span&gt;&lt;sup&gt;3&lt;/sup&gt;&lt;/span&gt; and aging&lt;span&gt;&lt;sup&gt;10&lt;/sup&gt;&lt;/span&gt; all influence body&lt;span&gt;&lt;sup&gt;10, 11&lt;/sup&gt;&lt;/span&gt; and organ weight variability. Inflammation due to infectious agents, age-related thymic atrophy, hepatic lipidosis in diabetes mellitus, and neoplasms are a few examples. Additionally, AGMs demonstrate sexual dimorphism&lt;span&gt;&lt;sup&gt;12&lt;/sup&gt;&lt;/span&gt; that results in differences in organ and body weights. Some studies also demonstrate that stress can considerably alter the body and adrenal gland weights.&lt;span&gt;&lt;sup&gt;13&lt;/sup&gt;&lt;/span&gt;&lt;/p&gt;&lt;p&gt;Among nonhuman primates, organ weight data have been published for baboons (&lt;i&gt;Papio hamadryas&lt;/i&gt;),&lt;span&gt;&lt;sup&gt;14, 15&lt;/sup&gt;&lt;/span&gt; rhesus macaques (&lt;i&gt;Macaca mulatta&lt;/i&gt;),&lt;span&gt;&lt;sup&gt;16&lt;/sup&gt;&lt;/span&gt; cynomolgus macaques (&lt;i&gt;Macaca fascicularis&lt;/i&gt;),&lt;span&gt;&lt;sup&gt;17&lt;/sup&gt;&lt;/span&gt; and stump-tailed macaques (&lt;i&gt;Macaca arctoides&lt;/i&gt;).&lt;span&gt;&lt;sup&gt;18&lt;/sup&gt;&lt;/span&gt; Normative organ weight data have not been reported for AGMs. Normative organ weights are used as reference points for the study of pathology in various research and diagnostic settings. Establishing a reference for age-associated organ weight changes in both sexes would be an important resource for primate researchers and pathologists. This study was conducted to provide normative body and organ weight data by age category and sex from the breeding colony of AGMs.&lt;/p&gt;&lt;p&gt;The scatterplots of body and organ weights age-by-sex are shown in Figures 1-16. Organ weights as a percentage of body weight age-by-sex are shown in Figures 17-31. Descriptive statistics by age category and sex are shown in Tables 2–6. Percentage organ weights by age category and sex are shown in Tables S1–S5.&lt;/p&gt;&lt;p&gt;AGMs are widely used in biomedical research, but a reference for normal organ weights and organ weights as percentages of body weights has not been previously reported. This retrospective study was designed to generate normal body and organ weights and their relationships to the body weight, providing a reference range for AGMs by sex and age ca","PeriodicalId":16439,"journal":{"name":"Journal of Medical Primatology","volume":"53 4","pages":""},"PeriodicalIF":0.8,"publicationDate":"2024-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jmp.12721","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141759295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lingual neoplasia in nonhuman primates: Description of five cases and a literature review","authors":"Alexis Berrocal,&nbsp;Krystal Vail,&nbsp;Olga Gonzalez,&nbsp;Vinay Shivanna,&nbsp;Edward J. Dick Jr,&nbsp;Tatiane Terumi Negrão Watanabe,&nbsp;Daniel Felipe Barrantes Murillo","doi":"10.1111/jmp.12725","DOIUrl":"10.1111/jmp.12725","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Documentation of lingual tumors is scarce in nonhuman primates.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Through a multi-institutional retrospective study we compile cases of primary and metastatic neoplasia in non-human primates.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>We describe five cases of lingual neoplasia. Three cases are primary lingual tumors: chondro-osteoblastic lipoma in a howler monkey, squamous cell carcinoma, and fibroma in two baboons. We describe two cases of metastatic lymphoma in the tongue in rhesus macaques. A literature review of published lingual neoplasia in nonhuman primates is included in this manuscript.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Lingual neoplasia is seldom reported in non-human primates.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16439,"journal":{"name":"Journal of Medical Primatology","volume":"53 4","pages":""},"PeriodicalIF":0.8,"publicationDate":"2024-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jmp.12725","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141734390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thyroblastoma in a rhesus macaque (Macaca mulatta): A case report","authors":"J. Greenberg,&nbsp;D. J. Wiener,&nbsp;S. J. Buchl,&nbsp;M. E. Hensel","doi":"10.1111/jmp.12724","DOIUrl":"10.1111/jmp.12724","url":null,"abstract":"<p>In this report, we describe the gross, histopathology, and immunohistochemical findings of a thyroblastoma that arose in the right lobe of the thyroid gland in a 2-month-old rhesus macaque (<i>Macaca mulatta</i>).</p>","PeriodicalId":16439,"journal":{"name":"Journal of Medical Primatology","volume":"53 4","pages":""},"PeriodicalIF":0.8,"publicationDate":"2024-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141626938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Defining blood hematology reference values in female pig-tailed macaques (Macaca nemestrina) using the Isolation Forest algorithm","authors":"Daniel Kim,&nbsp;Abigail Derton,&nbsp;George Khalil,&nbsp;Yi Pan,&nbsp;Shanon Bachman,&nbsp;Kristen Kelley,&nbsp;Gerardo Garcίa-Lerma,&nbsp;Charles W. Dobard,&nbsp;Michele B. Daly","doi":"10.1111/jmp.12723","DOIUrl":"10.1111/jmp.12723","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Pig-tailed macaques (PTMs) are commonly used as preclinical models to assess antiretroviral drugs for HIV prevention research. Drug toxicities and disease pathologies are often preceded by changes in blood hematology. To better assess the safety profile of pharmaceuticals, we defined normal ranges of hematological values in PTMs using an Isolation Forest (<i>i</i>Forest) algorithm.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Eighteen female PTMs were evaluated. Blood was collected 1–24 times per animal for a total of 159 samples. Complete blood counts were performed, and <i>i</i>Forest was used to analyze the hematology data to detect outliers.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Median, IQR, and ranges were calculated for 13 hematology parameters. From all samples, 22 outliers were detected. These outliers were excluded from the reference index.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Using <i>i</i>Forest, we defined a normal range for hematology parameters in female PTMs. This reference index can be a valuable tool for future studies evaluating drug toxicities in PTMs.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16439,"journal":{"name":"Journal of Medical Primatology","volume":"53 4","pages":""},"PeriodicalIF":0.8,"publicationDate":"2024-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jmp.12723","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141558907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hematology and serum biochemistry of free-ranging mantled howler monkeys (Alouatta palliata) at La Pacifica, Costa Rica","authors":"R. Scott Larsen,&nbsp;Anneke Moresco,&nbsp;Ana Meneses,&nbsp;Kenneth E. Glander","doi":"10.1111/jmp.12720","DOIUrl":"10.1111/jmp.12720","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Hematologic and blood biochemical values are key tools for assessing primate health. A long-term behavioral study of howler monkeys at a single site (La Pacífica, Guanacaste, Costa Rica), afforded the opportunity to develop baseline values for a large group of animals, evaluating differences between adult males and females and comparing to a report in the same population two decades later.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>In 1998, 64 free-ranging mantled howler monkeys were anesthetized and sampled for hematologic and biochemical analysis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Blood analysis is reported for 29 adult females, 9 juvenile females, 19 adult males and 3 juvenile males. Four adults were excluded due to external injury or disease. There were few significant differences between adult females, juvenile females, and adult males.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Baseline blood parameters are useful for determining normal values for howler monkey populations. The values for total protein, blood urea nitrogen, glucose, liver enzymes and potassium differed from a later study in 2019 may indicate changes that are influencing howler monkey health.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16439,"journal":{"name":"Journal of Medical Primatology","volume":"53 4","pages":""},"PeriodicalIF":0.8,"publicationDate":"2024-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141492256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An exploratory deep learning approach to investigate tuberculosis pathogenesis in nonhuman primate model: Combining automated radiological analysis with clinical and biomarkers data","authors":"Faisal Yaseen,&nbsp;Murtaza Taj,&nbsp;Resmi Ravindran,&nbsp;Fareed Zaffar,&nbsp;Paul A. Luciw,&nbsp;Aamer Ikram,&nbsp;Saerah Iffat Zafar,&nbsp;Tariq Gill,&nbsp;Michael Hogarth,&nbsp;Imran H. Khan","doi":"10.1111/jmp.12722","DOIUrl":"10.1111/jmp.12722","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Tuberculosis (TB) kills approximately 1.6 million people yearly despite the fact anti-TB drugs are generally curative. Therefore, TB-case detection and monitoring of therapy, need a comprehensive approach. Automated radiological analysis, combined with clinical, microbiological, and immunological data, by machine learning (ML), can help achieve it.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Six rhesus macaques were experimentally inoculated with pathogenic Mycobacterium tuberculosis in the lung. Data, including Computed Tomography (CT), were collected at 0, 2, 4, 8, 12, 16, and 20 weeks.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Our ML-based CT analysis (TB-Net) efficiently and accurately analyzed disease progression, performing better than standard deep learning model (LLM OpenAI's CLIP Vi4). TB-Net based results were more consistent than, and confirmed independently by, blinded manual disease scoring by two radiologists and exhibited strong correlations with blood biomarkers, TB-lesion volumes, and disease-signs during disease pathogenesis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The proposed approach is valuable in early disease detection, monitoring efficacy of therapy, and clinical decision making.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16439,"journal":{"name":"Journal of Medical Primatology","volume":"53 4","pages":""},"PeriodicalIF":0.8,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141468706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gastrointestinal helminths of captive proboscis monkey (Nasalis larvatus) in Surabaya zoo, Indonesia","authors":"Masyithah Ramadhani,&nbsp;Nanis Nurhidayah,&nbsp;Dyah Ayu Kurniawati,&nbsp;Muttaqin Purmadi,&nbsp;Fatih Aunur Rafiq,&nbsp;Eni Kusumaningtyas,&nbsp;Dwi Endrawati,&nbsp;Nanik Hidayatik,&nbsp;Ragil Angga Prastiya,&nbsp;Sela Septima Mariya,&nbsp; Mufasirin,&nbsp;Poedji Hastutiek","doi":"10.1111/jmp.12719","DOIUrl":"10.1111/jmp.12719","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>One of the constrain in proboscis monkey (<i>Nasalis larvatus</i>) conservation is gastrointestinal helminth (GH) infection. Here, we conducted a study to determine the prevalence of GHs in captive proboscis monkeys in Surabaya Zoo, Indonesia.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Twenty fecal samples were collected from three groups (i.e., nursery cage [NC] [<i>n</i> = 1], communal show cage [SC] [<i>n</i> = 8], and free-ranging colonies [FC] [<i>n</i> = 11]). The fecal samples have been examined through McMaster and sugar floatation techniques.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The total prevalence of GH infection was 85.00% (17/20). We confirmed infection of <i>Trichuris</i> sp., <i>Ascaris</i> sp., <i>Strongyloides</i> sp., and <i>Hymenolepis nana with Trichuris eggs was dominant.</i> Although the prevalence of infection was high, the number of eggs per gram (epg) was low.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>GH infection in captive proboscis monkeys in Surabaya Zoo, Indonesia, is highly prevalent. These results were useful for future research, control, and prevention of zoonotic potency purposes.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16439,"journal":{"name":"Journal of Medical Primatology","volume":"53 4","pages":""},"PeriodicalIF":0.8,"publicationDate":"2024-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141457470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fecal testosterone levels positively correlated with sexually motivated behaviors in male Tibetan macaques (Macaca thibetana)","authors":"Yong Zhu,&nbsp;Qixin Zhang,&nbsp;Ruisong Tao,&nbsp;Zhuozhi Gao,&nbsp;Dongpo Xia","doi":"10.1111/jmp.12718","DOIUrl":"https://doi.org/10.1111/jmp.12718","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Testosterone plays a crucial role in regulating sexual behavior among non-human primates, working primarily by increasing copulatory behavior and sexual motivation. In this study, we analyzed fecal testosterone levels in five adult male Tibetan macaques (<i>Macaca thibetana</i>) living freely in the Huangshan National Reserve in Anhui Province. The aim was to investigate the relationships between fecal testosterone levels and sexually motivated behaviors.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We collected a total of 426 fecal samples and observed approximately 453 h of focal sampling behavioral data. Sexually motivated behaviors were categorized as sexual chase, grimace, and sexual-inspection.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The results showed a positive correlation between sexually motivated behaviors and copulatory behavior. Furthermore, all the three sexually motivated behaviors, including sexual chase, grimace, and sexual-inspection, were positively correlated with fecal testosterone levels.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Our results demonstrated positive correlations between sexually motivated behaviors and fecal testosterone in free-ranging Tibetan macaques.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16439,"journal":{"name":"Journal of Medical Primatology","volume":"53 4","pages":""},"PeriodicalIF":0.8,"publicationDate":"2024-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141439580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oral cavity squamous cell carcinomas in zoo-managed Goeldi's monkeys (Callimico goeldii)","authors":"Andrew F. Rich,&nbsp;Imogen L. Payne,&nbsp;Rowena Killick,&nbsp;Daniela Denk,&nbsp;Nathalie Wissink-Argilaga","doi":"10.1111/jmp.12717","DOIUrl":"10.1111/jmp.12717","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Oral cavity squamous cell carcinomas (OCSCCs) are relatively common in multiple non-human primate species but are poorly documented in Goeldi's monkeys.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Four Goeldi's monkeys with OCSCC, from three zoological collections, underwent necropsy with cytology, histopathology, immunohistochemistry, and pan-herpesvirus PCR analysis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>All animals were euthanised and exhibited poor-to-emaciated body condition. Three OCSCCs arose from the maxillary oral mucosa and a single OCSCC was primarily mandibular, with bone invasion evident in three cases. Histologically, one OCSCC in situ was diagnosed, whilst the rest were typically invasive OCSCCs. Neoplastic cells were immunopositive for pancytokeratin and E-cadherin. All examined cases were negative for regional lymph node (RLN) and/or distant metastases, cyclooxygenase-2 (COX-2) immunoexpression, and panherpesvirus PCR expression.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>OCSCCs in Goeldi's monkeys may be deeply invasive, but not readily metastatic. No herpesvirus-association or COX-2 expression was evident; the latter suggesting that NSAIDs are unlikely to be a viable chemotherapeutic treatment.</p>\u0000 </section>\u0000 </div>","PeriodicalId":16439,"journal":{"name":"Journal of Medical Primatology","volume":"53 3","pages":""},"PeriodicalIF":0.7,"publicationDate":"2024-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141296268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}