Journal of Gastroenterology and Hepatology最新文献

{"title":"Natural History and Predictors of Clinical Outcomes in Autoimmune Liver Diseases: A Multicenter Study.","authors":"Dujinthan Jayabalan, Yi Huang, Luis Calzadilla-Bertot, Leon A Adams, Wendy Cheng, Simon Hazeldine, Briohny W Smith, Gerry C MacQuillan, Michael C Wallace, George Garas, Gary P Jeffrey","doi":"10.1111/jgh.16850","DOIUrl":"https://doi.org/10.1111/jgh.16850","url":null,"abstract":"<p><strong>Background and aim: </strong>Prognosis in autoimmune hepatitis (AIH), primary biliary cholangitis (PBC), and primary sclerosing cholangitis (PSC) has historically been poor. This multicenter retrospective cohort study investigated the natural history and assessed the predictors of outcomes in patients with AIH, PBC, and PSC.</p><p><strong>Methods: </strong>AIH, PBC, and PSC patients were identified from the state-wide Hepascore and Clinical Outcome cohort. Overall death or transplant, liver-related mortality (liver-related death or transplant), and liver-related decompensation were determined using a population-based data linkage system. Baseline Liver Outcome Score (LOS), Hepascore, and MELD were examined for predicting outcomes.</p><p><strong>Results: </strong>Two-hundred thirty-seven AIH patients (24% male, median age 56.6 years [range, 14.3-94.0]), 157 PBC patients (8.3% male, median age 60.5 years [range, 25.6-87.1]), and 167 PSC patients (52.7% male, median age 55.6 years [range, 18.4-88.6]) were enrolled. Five-year transplant-free survival was 88% (95%CI: 81-92%) in AIH, 92% (95%CI: 85-96%) in PBC, and 61% (95%CI: 51-69%) in PSC. PSC had a significantly worse overall death or transplant, liver-related mortality, and liver-related decompensation when compared to AIH and PBC (p < 0.0001). LOS was a significant independent predictor of overall death or transplant, liver-related mortality, and liver-related decompensation among patients with AIH and PBC. LOS was a significant independent predictor of overall death or transplant in patients with PSC, and Hepascore was a significant independent predictor of liver-related mortality and liver-related decompensation.</p><p><strong>Conclusions: </strong>Outcomes for AIH and PBC are excellent but remain poor in PSC. LOS is a predictor of outcomes in autoimmune liver disease.</p>","PeriodicalId":15877,"journal":{"name":"Journal of Gastroenterology and Hepatology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142837111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Risk-Scoring Models to Predict Gastrointestinal Bleeding in Patients With Direct Oral Anticoagulants.","authors":"Ilsoo Kim, Joon Sung Kim, Dae Young Cheung, Byung-Wook Kim, Jong-Uk Hou","doi":"10.1111/jgh.16853","DOIUrl":"https://doi.org/10.1111/jgh.16853","url":null,"abstract":"<p><strong>Background and aim: </strong>The risk of gastrointestinal bleeding (GIB) remains a concern with the use of direct oral anticoagulants (DOAC). We evaluated the efficacy of four risk-scoring models (HAS-BLED, ATRIA, VTE-BLEED, and ORBIT) in predicting GIB according to the concomitant use of antiplatelet therapy in DOAC users.</p><p><strong>Methods: </strong>Patients prescribed DOAC between December 2014 and October 2020 were enrolled in two university-affiliated hospitals. The performance of the four models was compared based on the concomitant use of antiplatelet therapy. The primary outcomes were likelihood ratios and the area under the receiver operating characteristic (AUROC) curve to predict GIB.</p><p><strong>Results: </strong>A total of 4494 patients were included in the study. The AUROC values for the entire cohort were 0.643 (95% CI: 0.601-0.686) for HAS-BLED, 0.693 (95% CI: 0.649-0.737) for ATRIA, 0.708 (95% CI: 0.665-0.750) for VTE-BLEED, and 0.709 (95% CI: 0.667-0.751) for ORBIT. The AUROC for all scoring models increased in patients without antiplatelet therapy compared to the entire cohort and patients with antiplatelet therapy. The specificity and diagnostic accuracy for all scoring models increased in patients without antiplatelet therapy compared to patients with antiplatelet.</p><p><strong>Conclusions: </strong>Our results confirmed that current risk-scoring models for predicting GIB perform better in patients without antiplatelet therapy than in those on concomitant antiplatelet therapy. This suggests that future risk prediction models should consider the concomitant use of antiplatelet therapy for diagnostic accuracy.</p>","PeriodicalId":15877,"journal":{"name":"Journal of Gastroenterology and Hepatology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142837172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gastrointestinal: Successful Management of Refractory Achalasia Complicated by Delayed Diagnosis and Prolonged Sepsis.","authors":"Dauda Bawa, Rajvinder Singh","doi":"10.1111/jgh.16855","DOIUrl":"https://doi.org/10.1111/jgh.16855","url":null,"abstract":"","PeriodicalId":15877,"journal":{"name":"Journal of Gastroenterology and Hepatology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142829104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Postcholecystectomy Gut Microbiome Changes and the Clinical Impact: A Systematic Review With Narrative Synthesis.","authors":"Tiing Leong Ang, Seok Hwee Koo, Daphne Ang, Chin Kimg Tan, Lai Mun Wang, Sunny Hei Wong, Pierce K H Chow","doi":"10.1111/jgh.16846","DOIUrl":"https://doi.org/10.1111/jgh.16846","url":null,"abstract":"<p><strong>Background: </strong>Cholecystectomy (CCE) can affect the enterohepatic circulation of bile acids and result in gut microbiome changes. This systematic review aimed to clarify the effect of CCE on gut microbiome composition and its clinical impact.</p><p><strong>Method: </strong>A systematic search was conducted in PubMed, Web of Science, and Scopus, combining keywords such as \"cholecystectomy\" or \"post-cholecystectomy\" with \"gut microbiome,\" \"stool microbiome,\" or \"gut dysbiosis.\" Data were extracted and synthesized using narrative review. Study quality was assessed using the Newcastle-Ottawa scale.</p><p><strong>Results: </strong>A total of 1373 articles were screened and 14 studies were selected. Significant but inconsistent microbiome changes were reported. Changes were observed in alpha and beta diversity. At phylum level, an increase in Bacteroides and Ascomycota, decrease in Firmicutes, Actinomycetes, and Basidiomycota, and both increase and decrease in Fusobacteria were reported. At genus level, an increase in Prevotella and a decrease in Faecalibacterium were reported. In post-CCE diarrhea, decreased beta diversity, a decreased F/B ratio, an increase in Prevotella, an increase in Phocaeicola vulgatus, and a decrease in Prevotella copri were noted. For post-CCE syndrome, a higher abundance of Proteobacteria and decreased Firmicutes/Bacteroides (F/B) ratio were reported. A decreased relative abundance of Bifidobacterium longum subsp. longum from controls to CCE without colonic neoplasia to CCE with colonic neoplasia, and an increased abundance of Candida glabrata from controls, to CCE without colonic neoplasia and CCE with colonic neoplasia, were reported.</p><p><strong>Conclusion: </strong>Patients who underwent CCE had significant gut dysbiosis. However, current studies could not clarify the detailed gut microbial structural and functional changes associated with CCE.</p>","PeriodicalId":15877,"journal":{"name":"Journal of Gastroenterology and Hepatology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142829105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to \"Menstrual blood-derived mesenchymal stem cells attenuate inflammation and improve the mortality of acute liver failure combining with A2AR agonist in mice\".","authors":"","doi":"10.1111/jgh.16848","DOIUrl":"https://doi.org/10.1111/jgh.16848","url":null,"abstract":"","PeriodicalId":15877,"journal":{"name":"Journal of Gastroenterology and Hepatology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142829103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Moderated Poster Presentation","authors":"","doi":"10.1111/jgh.16778","DOIUrl":"10.1111/jgh.16778","url":null,"abstract":"&lt;p&gt;&lt;b&gt;MP-01-01&lt;/b&gt;&lt;/p&gt;&lt;p&gt;&lt;b&gt;Bloody stool: diagnosis from colonoscopy findings in Dr. Cipto Mangunkusumo General National Hospital&lt;/b&gt;&lt;/p&gt;&lt;p&gt;&lt;b&gt;Saskia Nursyirwan&lt;/b&gt;&lt;sup&gt;1&lt;/sup&gt; and Izzati Diyanah&lt;sup&gt;2&lt;/sup&gt;&lt;/p&gt;&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;&lt;i&gt;Division of Gastroenterology, Pancreatobiliary, and Digestive Endoscopy, Department of Internal Medicine, Dr. Cipto Mangunkusumo Hospital/Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia;&lt;/i&gt; &lt;sup&gt;2&lt;/sup&gt;&lt;i&gt;Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia&lt;/i&gt;&lt;/p&gt;&lt;p&gt;Moderated Poster 1, November 22, 2024, 12:20 PM - 12:50 PM.&lt;/p&gt;&lt;p&gt;&lt;b&gt;&lt;i&gt;Objectives:&lt;/i&gt;&lt;/b&gt; A colonoscopy is a diagnostic and therapeutic tool widely used to confirm the diagnosis of digestive tract diseases, including GI bleeding. It is beneficial in determining the etiology of a complaint. Bloody stool is one of the complaints frequently encountered in health facilities. This study examines the various colonoscopy findings in patients with bloody stool who underwent gastrointestinal colonoscopy. It is essential to determine the enforcement of the diagnosis and provide appropriate management.&lt;/p&gt;&lt;p&gt;&lt;b&gt;&lt;i&gt;Materials and methods:&lt;/i&gt;&lt;/b&gt; Data were retrospectively collected and analyzed from the medical records of patients who underwent colonoscopy procedures between 2021–2023 at Digestive Endoscopy Center, Dr. Cipto Mangunkusumo General National Hospital.&lt;/p&gt;&lt;p&gt;&lt;b&gt;&lt;i&gt;Results:&lt;/i&gt;&lt;/b&gt; Between 2021 and 2023, data from 1,120 colonoscopy patients at Dr. Cipto Mangunkusumo General National Hospital revealed that 656 (58.6%) were female and 464 (41.4%) were male. Among the 372 patients reporting bloody stool. The most common findings were internal or external hemorrhoids (38.98%), followed by proctitis (18.28%), and other findings that were dominated by tumors or masses (17.5%). Other diagnoses included polyps (12.36%), ileitis (9.7%), colorectal cancer (7.26%), ulcerative colitis (5.64%), and Crohn's disease (5.1%). Diverticulosis and rectal ulcers were each identified in 11 patients (2.96%). On the other hand, 12 patients (3.22%) were identified as normal in their colonoscopy results.&lt;/p&gt;&lt;p&gt;&lt;b&gt;&lt;i&gt;Conclusion:&lt;/i&gt;&lt;/b&gt; This study found that most colonoscopy findings in patients with bloody stool are internal or external hemorrhoids, followed by proctitis and other findings that were dominated by tumors or masses.&lt;/p&gt;&lt;p&gt;&lt;b&gt;MP-01-02&lt;/b&gt;&lt;/p&gt;&lt;p&gt;&lt;b&gt;Effect and safety of sofosbuvir/velpatasvir/voxilaprevir for patients with CHC previously treated with DAAs&lt;/b&gt;&lt;/p&gt;&lt;p&gt;Sangdeok Shin&lt;sup&gt;1&lt;/sup&gt;, Sung Hwan Yoo&lt;sup&gt;2,3&lt;/sup&gt;, Tae Seop Lim&lt;sup&gt;2,4&lt;/sup&gt;, Chang Won Ha&lt;sup&gt;1&lt;/sup&gt;, Byeong Geun Song&lt;sup&gt;1&lt;/sup&gt;, Myung Ji Goh&lt;sup&gt;1&lt;/sup&gt;, Dong Hyun Shin&lt;sup&gt;1&lt;/sup&gt;, Geum-Youn Gwak&lt;sup&gt;1&lt;/sup&gt;, Young Han Paik&lt;sup&gt;1,6&lt;/sup&gt;, Moon Seok Choi&lt;sup&gt;1&lt;/sup&gt;, Hye Won Lee&lt;sup&gt;2,5&lt;/sup&gt; and Wonseok Kang&lt;sup&gt;1,6&lt;/sup&gt;&lt;/p&gt;&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;&lt;i&gt;Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine;&lt;/i&gt; &lt;sup&gt;2&lt;/sup&gt;&lt;i&gt;Department of Internal ","PeriodicalId":15877,"journal":{"name":"Journal of Gastroenterology and Hepatology","volume":"39 S2","pages":"28-36"},"PeriodicalIF":3.7,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jgh.16778","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142818284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identifying Risk Factors of Major Adverse Cardiac Events in Patients With Ulcerative Colitis: A Retrospective Japanese Claims Data Analysis.","authors":"Tomohisa Takagi, Linghua Xu, Masato Hoshi, Shoko Arai","doi":"10.1111/jgh.16831","DOIUrl":"https://doi.org/10.1111/jgh.16831","url":null,"abstract":"<p><strong>Background and aim: </strong>We conducted a retrospective study to identify incidence rates and potential risk factors of major adverse cardiac events (MACE) in Japanese patients with ulcerative colitis (UC), as existing data are scarce, inconsistent, and provide limited representation of the real-world situation of MACE in Japan.</p><p><strong>Methods: </strong>We utilized administrative claims data, collected between January 2013 and December 2022, from Medical Data Vision, Japan. Patients (aged ≥ 20 years) diagnosed with UC within ± 1 month of the prescription date during the study period were included in the incident cohort. Exclusions comprised patients diagnosed with UC in the first 365 days or with myocardial infarction, heart failure, stroke, or other ischemic heart diseases within 30 days pre-index. The cumulative incidence rate of MACE was calculated using the Kaplan-Meier method. Multivariate Cox regression models were used to calculate hazard ratios (HRs) for all relevant potential risk factors.</p><p><strong>Results: </strong>Of 11 407 patients in the incident cohort, 91 (0.8%) experienced incident MACE. Over 120 months, the cumulative incidence rate of MACE was 2.86% (95% confidence interval [CI]: 1.89-4.32). Significant HRs (95% CI) were found for age category (≥ 65 years) (4.557 [2.786-7.452]), diabetes (1.709 [1.030-2.835]), and atrial fibrillation (AF) (2.759 [1.188-6.405]) (all p < 0.05). Patients with a history of stroke showed numerically increased risk (1.871 [0.508-6.886]) of MACE.</p><p><strong>Conclusions: </strong>The cumulative incidence rate of MACE was 2.86% over 120 months. Age, comorbidities of diabetes and AF, and history of stroke were the major risk factors for MACE in Japanese UC patients.</p>","PeriodicalId":15877,"journal":{"name":"Journal of Gastroenterology and Hepatology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142813002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Foreword from the APDW 2024 Congress president","authors":"","doi":"10.1111/jgh.16818","DOIUrl":"10.1111/jgh.16818","url":null,"abstract":"<p>The APDW Congress last came to Bali in 2014 to great success, and we are pleased to once again welcome you to the beautiful island of Bali.</p><p>This year, we received more than 1500 abstracts from 1100 authors for presentation at the APDW2024 Congress. Within this abstract supplement, we have curated some of the best and most exciting research carried out over the past year.</p><p>The digitization of medical education over the past few years has significantly improved the ease of access to knowledge, but has also resulted in the compartmentalization and regionalization of medical education across the Asia-Pacific region.</p><p>Through APDW 2024, we seek to reaffirm the core ideals of the APDWF with the deepening of understanding and collaboration with colleagues across the myriad yet important specialties spanning gastroenterology, hepatology, digestive endoscopy, and digestive surgery.</p><p>The great response in terms of registrations and abstract submissions has reaffirmed our belief that the diversity of solutions made possible by a multidisciplinary approach represents the greatest ideal in optimizing patient management and that the APDW Congress serves as an important vehicle in which to connect with colleagues across diverse backgrounds and experiences to elevate the standards of our patient care.</p><p>On behalf of the Local Organizing Committee, thank you for joining us for the finale of this incredible 2-year journey. I trust that the knowledge revealed in this abstract supplement will serve you well in your practice.</p><p>Professor Dadang Makmun</p><p>President, APDW2024-Bali</p>","PeriodicalId":15877,"journal":{"name":"Journal of Gastroenterology and Hepatology","volume":"39 S2","pages":"23"},"PeriodicalIF":3.7,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jgh.16818","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142818345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of Computer-Aided Device on Adenoma Detection Rate in Different Implement Scenarios: A Real-World Study.","authors":"Chenxia Zhang, Xiao Tao, Jie Pan, Li Huang, Zehua Dong, Jiejun Lin, Huang Su, Yijie Zhu, Hongliu Du, Bing Xiao, Mingkai Chen, Lianlian Wu, Honggang Yu","doi":"10.1111/jgh.16847","DOIUrl":"https://doi.org/10.1111/jgh.16847","url":null,"abstract":"<p><strong>Background: </strong>Several recent studies have found that the efficacy of computer-aided polyp detection (CADe) on the adenoma detection rate (ADR) diminished in real-world settings. The role of unmeasured factors in AI-human interaction, such as monitor approaches, remains unknown. This study aimed to validate the effectiveness of CADe in the real world and assess the impact of monitor approaches.</p><p><strong>Methods: </strong>A retrospective propensity score-matched cohort study was conducted using routine data from a tertiary endoscopy center in China before and after the implementation of CADe. Four propensity score-matched cohorts were established: Cohort 1: pre-CADe matched with dual-monitor CADe-assisted group; Cohort 2: dual-monitor CADe-assisted with single-monitor CADe-assisted group; Cohort 3: pre-CADe with single-monitor CADe-assisted group; and Cohort 4: pre-CADe with CADe period. ADR was set as the primary outcome.</p><p><strong>Results: </strong>There were 5390, 6083, and 6131 eligible patients in the pre-CADe group, dual-monitor group, and single-monitor group, respectively. In the matched analysis, results indicated that regardless of the monitor setup, CADe-assisted groups showed a trend of increased ADR compared with the pre-CADe period (CADe period: OR 1.141, 95% CI 1.047-1.243; p = 0.003; dual-monitor: OR 1.178, 95% CI 1.069-1.299, p = 0.001; single-monitor: OR 1.094, 95% CI 0.998-1.200, p = 0.056). Moreover, no significant difference between different monitor approaches was observed, although dual-monitor setup showed an increasing tendency on ADR compared with single-monitor setup (OR 1.069, 95% CI 0.985-1.161, p = 0.109).</p><p><strong>Conclusion: </strong>CADe shows great potential to improve ADR during colonoscopy in the real world. Meanwhile, changes in monitor setup do not significantly impact the assistance capability of CADe. Further research dedicated to evaluating the unmeasured elements in the AI-clinician hybrid for better implementation of CADe would be beneficial.</p>","PeriodicalId":15877,"journal":{"name":"Journal of Gastroenterology and Hepatology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142813065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Poster Presentations","authors":"","doi":"10.1111/jgh.16780","DOIUrl":"10.1111/jgh.16780","url":null,"abstract":"&lt;p&gt;&lt;b&gt;PP-01-001&lt;/b&gt;&lt;/p&gt;&lt;p&gt;&lt;b&gt;Long-term prognosis after ESD for superficial spreading esophageal squamous cell carcinoma of ≥50 mm&lt;/b&gt;&lt;/p&gt;&lt;p&gt;&lt;b&gt;Satoshi Masuda&lt;/b&gt;&lt;sup&gt;1&lt;/sup&gt;, Yuji Urabe&lt;sup&gt;1&lt;/sup&gt;, Takahiro Uda&lt;sup&gt;1&lt;/sup&gt;, Tomoyuki Gurita&lt;sup&gt;1&lt;/sup&gt;, Yoshiki Hatsushika&lt;sup&gt;1&lt;/sup&gt;, Yukiko Sako&lt;sup&gt;1&lt;/sup&gt;, Takeo Nakamura&lt;sup&gt;1&lt;/sup&gt;, Kazuki Ishibashi&lt;sup&gt;1&lt;/sup&gt;, Hirona Konishi&lt;sup&gt;1&lt;/sup&gt;, Junichi Mizuno&lt;sup&gt;1&lt;/sup&gt;, Yuichi Hiyama&lt;sup&gt;1&lt;/sup&gt;, Akira Ishikawa&lt;sup&gt;2&lt;/sup&gt;, Toshio Kuwai&lt;sup&gt;1&lt;/sup&gt; and Shiro Oka&lt;sup&gt;1&lt;/sup&gt;&lt;/p&gt;&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;&lt;i&gt;Department of Gastroenterology, Hiroshima University Hospital;&lt;/i&gt; &lt;sup&gt;2&lt;/sup&gt;&lt;i&gt;Department of Molecular Pathology, Graduate School of Biomedical and Health Sciences, Hiroshima University&lt;/i&gt;&lt;/p&gt;&lt;p&gt;Poster (Day 1), Poster Area, November 22, 2024, 8:30 AM - 5:00 PM&lt;/p&gt;&lt;p&gt;&lt;b&gt;&lt;i&gt;Objective:&lt;/i&gt;&lt;/b&gt; To evaluate the outcomes and prognosis after ESD for superficial spreading esophageal squamous cell carcinoma (SESCC).&lt;/p&gt;&lt;p&gt;&lt;b&gt;&lt;i&gt;Subjects and Methods:&lt;/i&gt;&lt;/b&gt; We examined treatment outcomes (en bloc resection rate, tumor depth, lymphovascular invasion, and complications) in 79 patients with SESCC of 50 mm or more diameter and 79 lesions who underwent ESD between 2011 and 2018 at our department (observation period 86.9±33.2 months).&lt;/p&gt;&lt;p&gt;&lt;b&gt;&lt;i&gt;Results:&lt;/i&gt;&lt;/b&gt; En bloc resection rate was 99% (78/79). Tumor depth was pT1a-EP/LPM 45 (57%), pT1a-MM 16 (20%), pT1b-SM1 5 (6%), pT1b-SM2 13 (16%), lymphovascular invasion was observed in 12 (15%). No postoperative bleeding, intraoperative perforation in 4 (5%), and refractory stenosis (≥5 times endoscopic balloon dilatation) in 32 (41%) were observed. No local recurrence was observed, and 16 patients received additional treatment (CRT in 12, and operation in 4). Prognosis was 91%/84% for overall survival, 87%/80% for recurrence-free survival, and 77%/67% for disease-free surviva (3/5 years). Lymph node or other organ metastasis was observed in 6 patients (pT1a-MM,Ly0,V0/pT1b-SM1/pT1b-SM2 3/1/2). Death due to the primary disease was observed in 4 patients (pT1a-MM,Ly0,V0/pT1b-SM1/pT1b-SM2 2/1/1).&lt;/p&gt;&lt;p&gt;&lt;b&gt;&lt;i&gt;Conclusion:&lt;/i&gt;&lt;/b&gt; Although ESD for SESCC could be safely performed with en bloc resection, metastasis and primary death were observed in pT1a-MM lymphovascular invasion-negative cases that did not receive any additional treatment.&lt;/p&gt;&lt;p&gt;&lt;b&gt;PP-01-002&lt;/b&gt;&lt;/p&gt;&lt;p&gt;&lt;b&gt;A rare case of mycobacterium avium complex enteritis in advanced HIV&lt;/b&gt;&lt;/p&gt;&lt;p&gt;&lt;b&gt;Isaac Chan&lt;/b&gt;&lt;sup&gt;1&lt;/sup&gt;, Alyssa Sim&lt;sup&gt;2&lt;/sup&gt;, Raymond Liang&lt;sup&gt;2&lt;/sup&gt;, Hwei Yee Lee&lt;sup&gt;2&lt;/sup&gt; and Stephanie Sutjipto&lt;sup&gt;3&lt;/sup&gt;&lt;/p&gt;&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;&lt;i&gt;National Healthcare Group, Singapore, Singapore;&lt;/i&gt; &lt;sup&gt;2&lt;/sup&gt;&lt;i&gt;Tan Tock Seng Hospital, Singapore, Singapore;&lt;/i&gt; &lt;sup&gt;3&lt;/sup&gt;&lt;i&gt;National Centre for Infectious Diseases, Singapore, Singapore&lt;/i&gt;&lt;/p&gt;&lt;p&gt;Poster (Day 1), Poster Area, November 22, 2024, 8:30 AM - 5:00 PM&lt;/p&gt;&lt;p&gt;&lt;b&gt;&lt;i&gt;Introduction:&lt;/i&gt;&lt;/b&gt; Mycobacterium Avium Complex (MAC) infection is an AIDS-defining oppor","PeriodicalId":15877,"journal":{"name":"Journal of Gastroenterology and Hepatology","volume":"39 S2","pages":"182-487"},"PeriodicalIF":3.7,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jgh.16780","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142818305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}