Journal of Gastroenterology and Hepatology最新文献

{"title":"The Effect of Computer-Aided Device on Adenoma Detection Rate in Different Implement Scenarios: A Real-World Study.","authors":"Chenxia Zhang, Xiao Tao, Jie Pan, Li Huang, Zehua Dong, Jiejun Lin, Huang Su, Yijie Zhu, Hongliu Du, Bing Xiao, Mingkai Chen, Lianlian Wu, Honggang Yu","doi":"10.1111/jgh.16847","DOIUrl":"https://doi.org/10.1111/jgh.16847","url":null,"abstract":"<p><strong>Background: </strong>Several recent studies have found that the efficacy of computer-aided polyp detection (CADe) on the adenoma detection rate (ADR) diminished in real-world settings. The role of unmeasured factors in AI-human interaction, such as monitor approaches, remains unknown. This study aimed to validate the effectiveness of CADe in the real world and assess the impact of monitor approaches.</p><p><strong>Methods: </strong>A retrospective propensity score-matched cohort study was conducted using routine data from a tertiary endoscopy center in China before and after the implementation of CADe. Four propensity score-matched cohorts were established: Cohort 1: pre-CADe matched with dual-monitor CADe-assisted group; Cohort 2: dual-monitor CADe-assisted with single-monitor CADe-assisted group; Cohort 3: pre-CADe with single-monitor CADe-assisted group; and Cohort 4: pre-CADe with CADe period. ADR was set as the primary outcome.</p><p><strong>Results: </strong>There were 5390, 6083, and 6131 eligible patients in the pre-CADe group, dual-monitor group, and single-monitor group, respectively. In the matched analysis, results indicated that regardless of the monitor setup, CADe-assisted groups showed a trend of increased ADR compared with the pre-CADe period (CADe period: OR 1.141, 95% CI 1.047-1.243; p = 0.003; dual-monitor: OR 1.178, 95% CI 1.069-1.299, p = 0.001; single-monitor: OR 1.094, 95% CI 0.998-1.200, p = 0.056). Moreover, no significant difference between different monitor approaches was observed, although dual-monitor setup showed an increasing tendency on ADR compared with single-monitor setup (OR 1.069, 95% CI 0.985-1.161, p = 0.109).</p><p><strong>Conclusion: </strong>CADe shows great potential to improve ADR during colonoscopy in the real world. Meanwhile, changes in monitor setup do not significantly impact the assistance capability of CADe. Further research dedicated to evaluating the unmeasured elements in the AI-clinician hybrid for better implementation of CADe would be beneficial.</p>","PeriodicalId":15877,"journal":{"name":"Journal of Gastroenterology and Hepatology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142813065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Poster Presentations","authors":"","doi":"10.1111/jgh.16780","DOIUrl":"10.1111/jgh.16780","url":null,"abstract":"&lt;p&gt;&lt;b&gt;PP-01-001&lt;/b&gt;&lt;/p&gt;&lt;p&gt;&lt;b&gt;Long-term prognosis after ESD for superficial spreading esophageal squamous cell carcinoma of ≥50 mm&lt;/b&gt;&lt;/p&gt;&lt;p&gt;&lt;b&gt;Satoshi Masuda&lt;/b&gt;&lt;sup&gt;1&lt;/sup&gt;, Yuji Urabe&lt;sup&gt;1&lt;/sup&gt;, Takahiro Uda&lt;sup&gt;1&lt;/sup&gt;, Tomoyuki Gurita&lt;sup&gt;1&lt;/sup&gt;, Yoshiki Hatsushika&lt;sup&gt;1&lt;/sup&gt;, Yukiko Sako&lt;sup&gt;1&lt;/sup&gt;, Takeo Nakamura&lt;sup&gt;1&lt;/sup&gt;, Kazuki Ishibashi&lt;sup&gt;1&lt;/sup&gt;, Hirona Konishi&lt;sup&gt;1&lt;/sup&gt;, Junichi Mizuno&lt;sup&gt;1&lt;/sup&gt;, Yuichi Hiyama&lt;sup&gt;1&lt;/sup&gt;, Akira Ishikawa&lt;sup&gt;2&lt;/sup&gt;, Toshio Kuwai&lt;sup&gt;1&lt;/sup&gt; and Shiro Oka&lt;sup&gt;1&lt;/sup&gt;&lt;/p&gt;&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;&lt;i&gt;Department of Gastroenterology, Hiroshima University Hospital;&lt;/i&gt; &lt;sup&gt;2&lt;/sup&gt;&lt;i&gt;Department of Molecular Pathology, Graduate School of Biomedical and Health Sciences, Hiroshima University&lt;/i&gt;&lt;/p&gt;&lt;p&gt;Poster (Day 1), Poster Area, November 22, 2024, 8:30 AM - 5:00 PM&lt;/p&gt;&lt;p&gt;&lt;b&gt;&lt;i&gt;Objective:&lt;/i&gt;&lt;/b&gt; To evaluate the outcomes and prognosis after ESD for superficial spreading esophageal squamous cell carcinoma (SESCC).&lt;/p&gt;&lt;p&gt;&lt;b&gt;&lt;i&gt;Subjects and Methods:&lt;/i&gt;&lt;/b&gt; We examined treatment outcomes (en bloc resection rate, tumor depth, lymphovascular invasion, and complications) in 79 patients with SESCC of 50 mm or more diameter and 79 lesions who underwent ESD between 2011 and 2018 at our department (observation period 86.9±33.2 months).&lt;/p&gt;&lt;p&gt;&lt;b&gt;&lt;i&gt;Results:&lt;/i&gt;&lt;/b&gt; En bloc resection rate was 99% (78/79). Tumor depth was pT1a-EP/LPM 45 (57%), pT1a-MM 16 (20%), pT1b-SM1 5 (6%), pT1b-SM2 13 (16%), lymphovascular invasion was observed in 12 (15%). No postoperative bleeding, intraoperative perforation in 4 (5%), and refractory stenosis (≥5 times endoscopic balloon dilatation) in 32 (41%) were observed. No local recurrence was observed, and 16 patients received additional treatment (CRT in 12, and operation in 4). Prognosis was 91%/84% for overall survival, 87%/80% for recurrence-free survival, and 77%/67% for disease-free surviva (3/5 years). Lymph node or other organ metastasis was observed in 6 patients (pT1a-MM,Ly0,V0/pT1b-SM1/pT1b-SM2 3/1/2). Death due to the primary disease was observed in 4 patients (pT1a-MM,Ly0,V0/pT1b-SM1/pT1b-SM2 2/1/1).&lt;/p&gt;&lt;p&gt;&lt;b&gt;&lt;i&gt;Conclusion:&lt;/i&gt;&lt;/b&gt; Although ESD for SESCC could be safely performed with en bloc resection, metastasis and primary death were observed in pT1a-MM lymphovascular invasion-negative cases that did not receive any additional treatment.&lt;/p&gt;&lt;p&gt;&lt;b&gt;PP-01-002&lt;/b&gt;&lt;/p&gt;&lt;p&gt;&lt;b&gt;A rare case of mycobacterium avium complex enteritis in advanced HIV&lt;/b&gt;&lt;/p&gt;&lt;p&gt;&lt;b&gt;Isaac Chan&lt;/b&gt;&lt;sup&gt;1&lt;/sup&gt;, Alyssa Sim&lt;sup&gt;2&lt;/sup&gt;, Raymond Liang&lt;sup&gt;2&lt;/sup&gt;, Hwei Yee Lee&lt;sup&gt;2&lt;/sup&gt; and Stephanie Sutjipto&lt;sup&gt;3&lt;/sup&gt;&lt;/p&gt;&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;&lt;i&gt;National Healthcare Group, Singapore, Singapore;&lt;/i&gt; &lt;sup&gt;2&lt;/sup&gt;&lt;i&gt;Tan Tock Seng Hospital, Singapore, Singapore;&lt;/i&gt; &lt;sup&gt;3&lt;/sup&gt;&lt;i&gt;National Centre for Infectious Diseases, Singapore, Singapore&lt;/i&gt;&lt;/p&gt;&lt;p&gt;Poster (Day 1), Poster Area, November 22, 2024, 8:30 AM - 5:00 PM&lt;/p&gt;&lt;p&gt;&lt;b&gt;&lt;i&gt;Introduction:&lt;/i&gt;&lt;/b&gt; Mycobacterium Avium Complex (MAC) infection is an AIDS-defining oppor","PeriodicalId":15877,"journal":{"name":"Journal of Gastroenterology and Hepatology","volume":"39 S2","pages":"182-487"},"PeriodicalIF":3.7,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jgh.16780","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142818305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Foreword from the APDW federation president","authors":"","doi":"10.1111/jgh.16819","DOIUrl":"10.1111/jgh.16819","url":null,"abstract":"<p>I have the privilege to write the foreword on behalf of the Asian Pacific Digestive Week Federation (APDWF) for the APDW2024 Abstract Supplement published in the Journal of Gastroenterology and Hepatology. The APDW Congress is a reflection of APDWF's commitment to the expansion of cross-disciplinary education in Gastroenterology and Hepatology. Ground-breaking developments in Digestive Endoscopy and Digestive Surgical techniques from around the world in the last few decades have given us a wealth of options on top of traditional practices.</p><p>APDW Congress serves as a stage to unify the various disciplines in the pursuit of the optimization of patient care. It also provides a great platform for exchange of knowledge and networking. More than 3200 participants gathered in Bali, and among them, at least 40% will be sharing their work and research papers during the congress to an audience from 60 countries.</p><p>We trust some of the research work and latest development presented will inspire positive changes in your practices in the years ahead.</p><p>Justin Che-Yuen Wu</p><p>President</p><p>Asian Pacific Digestive Week Federation</p>","PeriodicalId":15877,"journal":{"name":"Journal of Gastroenterology and Hepatology","volume":"39 S2","pages":"24"},"PeriodicalIF":3.7,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jgh.16819","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142818353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Young Investigator's Award Finals","authors":"","doi":"10.1111/jgh.16777","DOIUrl":"10.1111/jgh.16777","url":null,"abstract":"&lt;p&gt;&lt;b&gt;YIA-01&lt;/b&gt;&lt;/p&gt;&lt;p&gt;&lt;b&gt;Piezo1-mediated lactate metabolism in intestinal vascular endothelial cell is involved in macrophage activation in IBD&lt;/b&gt;&lt;/p&gt;&lt;p&gt;Chang Liang and Yan Zhang&lt;/p&gt;&lt;p&gt;&lt;i&gt;Department of Gastroenterology, West China Hospital of Sichuan University, Chengdu, China&lt;/i&gt;&lt;/p&gt;&lt;p&gt;APDWF and JGHFoundation Young Investigator's Awards, November 23, 2024, 5:10 PM - 6:30 PM.&lt;/p&gt;&lt;p&gt;&lt;b&gt;&lt;i&gt;Objectives:&lt;/i&gt;&lt;/b&gt; In IBD patients, elevated mesenteric blood flow alters mechanical forces in intestinal vascular endothelial cells (VECs). These cells sense changes via the mechanosensitive ion channel Piezo1, converting mechanical stimuli into inflammatory signals and inducing inflammation. VECs also secrete lactate, contributing to inflammation. The role of Piezo1 in regulating intestinal vascular lactate metabolism in IBD remains unclear.&lt;/p&gt;&lt;p&gt;&lt;b&gt;&lt;i&gt;Materials and Methods:&lt;/i&gt;&lt;/b&gt; Single-cell sequencing was performed on colon tissues from IBD patients and healthy controls to investigate Piezo1 expression and lactate metabolism. Endothelial cell-specific Piezo1 knockout (Piezo1iΔEC/iΔEC) mice were generated and subjected to DSS-induced colitis. Inflammation severity, lactate levels in endothelial cells and plasma, and macrophage polarization were measured. HIF-1α-MCT signaling was explored.&lt;/p&gt;&lt;p&gt;&lt;b&gt;&lt;i&gt;Results:&lt;/i&gt;&lt;/b&gt; Piezo1 expression was significantly higher in the colonic mucosa of active IBD patients and DSS-induced colitis mice compared to controls. Single-cell sequencing showed Piezo1 enrichment in intestinal VECs in active IBD. Piezo1iΔEC/iΔEC mice with DSS-induced colitis showed reduced IL-6, TNF-α, IL-1β levels, decreased M1 macrophage activation, and lower lactate levels compared to controls. Piezo1 knockdown inhibited HIF-1α and MCT expression in VECs.&lt;/p&gt;&lt;p&gt;&lt;b&gt;YIA-02&lt;/b&gt;&lt;/p&gt;&lt;p&gt;&lt;b&gt;Prevalence and endoscopic characteristics of dyspepsia in Japanese adults: insights from a cancer screening initiative&lt;/b&gt;&lt;/p&gt;&lt;p&gt;Suguo Suzuki&lt;sup&gt;1&lt;/sup&gt;, Takeshi Kanno&lt;sup&gt;1,2&lt;/sup&gt;, Tomoyuki Koike&lt;sup&gt;1&lt;/sup&gt;, Takashi Chiba&lt;sup&gt;3&lt;/sup&gt;, Kiyotaka Asanuma&lt;sup&gt;3&lt;/sup&gt;, Katsuaki Kato&lt;sup&gt;3&lt;/sup&gt;, Yutaka Hatayama&lt;sup&gt;1&lt;/sup&gt;, Yohei Ogata&lt;sup&gt;1&lt;/sup&gt;, Masahiro Saito&lt;sup&gt;1&lt;/sup&gt;, Xiaoyi Jin&lt;sup&gt;1&lt;/sup&gt;, Waku Hatta&lt;sup&gt;1&lt;/sup&gt;, Kamane Uno&lt;sup&gt;1&lt;/sup&gt;, Akira Imatani&lt;sup&gt;1&lt;/sup&gt; and Atsushi Masamune&lt;sup&gt;1&lt;/sup&gt;&lt;/p&gt;&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;&lt;i&gt;Division of Gastroenterology, Tohoku University Graduate School of Medicine, Sendai, Japan;&lt;/i&gt; &lt;sup&gt;2&lt;/sup&gt;&lt;i&gt;R and D Division of Career Education for Medical Professionals, Medical Education Center, Jichi Medical University, Shimotsuke, Japan;&lt;/i&gt; &lt;sup&gt;3&lt;/sup&gt;&lt;i&gt;Miyagi Cancer Society, Sendai, Japan&lt;/i&gt;&lt;/p&gt;&lt;p&gt;APDWF and JGHFoundation Young Investigator's Awards, November 23, 2024, 5:10 PM - 6:30 PM.&lt;/p&gt;&lt;p&gt;&lt;b&gt;&lt;i&gt;Objectives:&lt;/i&gt;&lt;/b&gt; Dyspepsia is a significant social issue due to its negative impact on quality of life, with substantial cases showing no findings on upper gastrointestinal endoscopy (EGD). Recent Japanese epidemiologic reports on dyspeps","PeriodicalId":15877,"journal":{"name":"Journal of Gastroenterology and Hepatology","volume":"39 S2","pages":"25-27"},"PeriodicalIF":3.7,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jgh.16777","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142818258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oral Presentations","authors":"","doi":"10.1111/jgh.16779","DOIUrl":"10.1111/jgh.16779","url":null,"abstract":"&lt;p&gt;&lt;b&gt;OP-01-01&lt;/b&gt;&lt;/p&gt;&lt;p&gt;&lt;b&gt;Innovations in diagnosing indeterminate biliary strictures: Pilot comparison of the specs tool and peroral cholangioscopy&lt;/b&gt;&lt;/p&gt;&lt;p&gt;&lt;b&gt;James Emmanuel&lt;/b&gt; and Raman A/L Muthukaruppan&lt;/p&gt;&lt;p&gt;&lt;i&gt;Queen Elizabeth Hospital, Kota Kinabalu, Malaysia&lt;/i&gt;&lt;/p&gt;&lt;p&gt;Oral Presentation 1, APDW Theatre 1, Exhibition Hall, November 22, 2024, 10:30 AM - 11:50 AM&lt;/p&gt;&lt;p&gt;&lt;b&gt;&lt;i&gt;Objective:&lt;/i&gt;&lt;/b&gt; This study evaluates the diagnostic capabilities of a new tool, Stent Pusher- guided Endobiliary Forceps (SPECS) in assessing indeterminate biliary strictures.&lt;/p&gt;&lt;p&gt;&lt;b&gt;&lt;i&gt;Procedure (Material):&lt;/i&gt;&lt;/b&gt; SPECS procedure utilises a 10F sized stent pusher, advanced over a guidewire. Once pusher is correctly positioned with confirmation by fluoroscopy, contrast is injected via the pusher to redelineate the stricture followed by biopsies that are performed using a paediatric biopsy forceps.&lt;/p&gt;&lt;p&gt;&lt;b&gt;&lt;i&gt;Methods:&lt;/i&gt;&lt;/b&gt; 6 patients with indeterminate biliary strictures underwent evaluation and biopsy using ERCP and POCS followed by a tandem SPECS procedure. Key metrics evaluated included and the technical and clinical success, size of tissue samples, procedure length, and complications.&lt;/p&gt;&lt;p&gt;&lt;b&gt;&lt;i&gt;Results:&lt;/i&gt;&lt;/b&gt; Technical success for both procedures were 100%. SPECS demonstrated higher diagnostic accuracy compared to POCS 4/6 (66.7%) vs 2/6 (33.3%). Average size of tissue samples (mm) obtained with SPECS were comparable to those with POCS ( median 5.5 vs 4.0 ; p = 0.285). Procedure length (minutes) was shorter with SPECS (median 9.6 vs 14.6 ; p = 0.005). There were no complications reported for both methods.&lt;/p&gt;&lt;p&gt;&lt;b&gt;&lt;i&gt;Discussion:&lt;/i&gt;&lt;/b&gt; While both modalities have strengths, SPECS which allows contrast instillation, shows advantages in diagnostic accuracy, tissue adequacy and procedure duration. Although our study did not measure cost, accessories used in SPECS are generally more cost-effective. Additionally, SPECS addresses technical challenges and complications seen with free-handed cannulation with biopsy forceps.&lt;/p&gt;&lt;p&gt;&lt;b&gt;&lt;i&gt;Conclusion:&lt;/i&gt;&lt;/b&gt; Our study highlights SPECS as an effective alternative to POCS for biliary strictures; further research is needed to confirm findings and assess cost-effectiveness in larger populations.&lt;/p&gt;&lt;p&gt;&lt;b&gt;OP-01-02&lt;/b&gt;&lt;/p&gt;&lt;p&gt;&lt;b&gt;Differences in peroral cholangioscopic findings between primary sclerosing cholangitis and other bile duct diseases&lt;/b&gt;&lt;/p&gt;&lt;p&gt;&lt;b&gt;Taito Fukuma&lt;/b&gt;, Toshio Fujisawa and Hiroyuki Isayama&lt;/p&gt;&lt;p&gt;&lt;i&gt;Department of Gastroenterology, Graduate School of Medicine, Juntendo University, Tokyo, Japan&lt;/i&gt;&lt;/p&gt;&lt;p&gt;Oral Presentation 1, APDW Theatre 1, Exhibition Hall, November 22, 2024, 10:30 AM - 11:50 AM&lt;/p&gt;&lt;p&gt;&lt;b&gt;&lt;i&gt;Objective:&lt;/i&gt;&lt;/b&gt; To evaluate the utility of peroral cholangioscopy (POCS) in distinguishing primary sclerosing cholangitis (PSC) from cholangiocarcinoma by comparing POCS findings among PSC, cholangiocarcinoma, and intrahepatic stones.&lt;/p&gt;&lt;p&gt;&lt;b&gt;&lt;i&gt;Methods:&lt;/i&gt;&lt;/b&gt; We analyzed POCS findings from pati","PeriodicalId":15877,"journal":{"name":"Journal of Gastroenterology and Hepatology","volume":"39 S2","pages":"37-181"},"PeriodicalIF":3.7,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jgh.16779","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142818288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gastrointestinal: Direct Visualization of Biliary Tuberculosis.","authors":"Aniwat Saleepol, Thitinan Chulroek, Thanrada Vimonsuntirungsri, Thanawat Luangsukrerk","doi":"10.1111/jgh.16836","DOIUrl":"https://doi.org/10.1111/jgh.16836","url":null,"abstract":"<p><strong>Background: </strong>Biliary tuberculosis is a rare type of hepatobiliary tuberculosis. Clinical presentation, imaging, or cholangiogram are difficult to distinguish from other common causes of cholangiopathy or malignancy. Direct visualization of bile duct via cholangioscopy and targeted biopsy was introduced as one of effective investigations for tissue acquisition and diagnosis.</p><p><strong>Case report: </strong>We present a case of biliary tuberculosis presented with pruritus, progressive painless jaundice and significant weight loss. Laboratory findings showed an obstructive jaundice. MRI showed multifocal bile duct stricture and intrahepatic duct stone. Single operator cholangioscopy revealed ductal stricture with papillary projection at common hepatic duct and pigmented stone. Targeted biopsy was performed, which showed non-necrotizing granulomatous inflammation and detection of Mycobacterium tuberculosis complex DNA.</p><p><strong>Conclusion: </strong>Direct visualization via cholangioscopy can aid and increase diagnostic yield of biliary tuberculosis.</p>","PeriodicalId":15877,"journal":{"name":"Journal of Gastroenterology and Hepatology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142813001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative Efficacy and Safety of Lubiprostone and Osmotic Laxatives in Chronic Idiopathic Constipation: A Systematic Review and Network Meta-Analysis.","authors":"Luoyao Yang, Ye Zong, Fandong Meng, Yongdong Wu, Shutian Zhang","doi":"10.1111/jgh.16844","DOIUrl":"https://doi.org/10.1111/jgh.16844","url":null,"abstract":"<p><strong>Objective: </strong>The objective of this study is to compare the efficacy and safety of lubiprostone (Lub) with osmotic laxatives in the treatment of chronic idiopathic constipation (CIC).</p><p><strong>Methods: </strong>A comprehensive literature search was conducted using PubMed, EMBASE, and the Cochrane Library in May 2024. Studies that met the inclusion criteria were manually searched by two independent reviewers. The efficacy was assessed by the proportion of patients with spontaneous bowel movements (SBMs) within 24 h after the first administration of the medication and SBMs in Weeks 1 and 4. Safety was evaluated based on adverse events including nausea, diarrhea, and abdominal distension. Optimal probability values and the surface under the cumulative ranking area (SUCRA) were also calculated for all interventions. Higher SUCRA values indicate better efficacy and safety of the intervention.</p><p><strong>Results: </strong>Following a thorough search and screening process, 25 articles were included. Among the selected trials, 8 compared Lub to placebo, 10 compared polyethylene glycol (PEG) to placebo, 4 compared lactulose (Lac) to placebo, and 3 compared PEG to Lac. The meta-analysis results indicated that Lub and osmotic laxatives were significantly more effective than placebo. According to the SUCRA results, the highest rank probabilities were for Lub in increasing the SBMs and reducing abdominal distension.</p><p><strong>Conclusion: </strong>Lubiprostone is more effective than PEG and Lactulose for treating CIC, with comparable safety profiles. However, this conclusion requires further validation through large-scale, high-quality studies.</p>","PeriodicalId":15877,"journal":{"name":"Journal of Gastroenterology and Hepatology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142807263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Impact of Smoking on Ulcerative Colitis and Interaction With Family History: A Population-Based Cohort Study.","authors":"Hyeong Sik Ahn, Heather Swan, Sayada Zartasha Kazmi, Young Shin Kim, Gahwi Hong, Seeun Choi, Taeuk Kang, Minjung Kim, Jaewoo Cha, Hoo Jae Hann, Hyun Jung Kim","doi":"10.1111/jgh.16834","DOIUrl":"https://doi.org/10.1111/jgh.16834","url":null,"abstract":"<p><strong>Background: </strong>The impact of smoking on ulcerative colitis (UC) among Asian populations is controversial, and interactions between genetic factors and smoking are not well studied. We evaluated the association between smoking and UC and assessed interactions between smoking and family history.</p><p><strong>Methods: </strong>Using the National Health Insurance database, we identified 5.5 million individuals from 2002 to 2019 with information on familial relationships and smoking history. Cox proportional hazard regression was used to examine the association between UC and current/former smoking and estimate familial risk. Interactions between family history and smoking were assessed on an additive scale using relative excess risk due to interaction (RERI).</p><p><strong>Results: </strong>Current smoking was associated with a decreased risk of disease (hazard ratio [HR] 0.53 95% CI 0.49-0.56), whereas former smoking was associated with an increased risk (HR 1.62 95% CI 1.53-1.71), compared to nonsmokers. Familial risk was HR 7.51 (95% CI 6.68-8.48). The protective effect of current smoking was more pronounced among those with a family history, as their combined effect was lower than the sum of their individual risks (HR 4.37 vs. 7.55), whereas the harmful effect of former smoking was more prominent among this group, and their combined effect exceeded the sum of their individual effects (HR 10.20 vs. 8.57), indicating statistically significant interactions (RERI current: -3.18 95% CI -4.89 to -1.47; former: 1.63 95% CI -1.00-4.25).</p><p><strong>Conclusion: </strong>The effects of smoking on UC do not appear to differ between Asian and Western populations. Possible gene-smoking interactions were observed but in opposing directions for current/former smoking.</p>","PeriodicalId":15877,"journal":{"name":"Journal of Gastroenterology and Hepatology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142801020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Role of Antibiotic Exposure as a Risk Factor for IBD Epidemic: An Updated Meta-Analysis.","authors":"Fathimathul Henna, Javed Iqbal, Muhammad Saeed Qazi","doi":"10.1111/jgh.16845","DOIUrl":"https://doi.org/10.1111/jgh.16845","url":null,"abstract":"","PeriodicalId":15877,"journal":{"name":"Journal of Gastroenterology and Hepatology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142794836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between Triglyceride-Glucose Index and Risk of Gallstone Disease: A Prospective Cohort Study of 395 391 Individuals.","authors":"Hongyu Li, Guoheng Jiang, Wenqian Yu, Jing Luo, Shiyi Li, Linjun Xie, Xuan Bai, Yiting Xu, Yi Jiang, Menglin He, Jin Zhou, Xin Wang","doi":"10.1111/jgh.16828","DOIUrl":"https://doi.org/10.1111/jgh.16828","url":null,"abstract":"<p><strong>Objective: </strong>Gallstone disease (GSD) is one of the widespread gastrointestinal conditions. Triglyceride-glucose (TyG) index, a convenient surrogate for insulin resistance, may help identify and prevent gallstones. The present study aims to conduct a longitudinal study to evaluate the association between TyG index and the risk of GSD using the UK Biobank cohort.</p><p><strong>Method: </strong>A total of 395 391 participants in the UK Biobank (median follow-up of 12.52 years) were included. The association between TyG index and the risk of GSD was assessed through Cox models and the restricted cubic spline model, expressed by hazard ratios (HRs) and 95% confidence intervals (CIs). Subgroup analysis was employed concerning age, gender, and body mass index (BMI) and also analyzed the mediating role of BMI in the effect of TyG index on incident GSD. Sensitivity analyses were further performed using a competing risks model and excluding participants who developed GSD in the first year of follow-up to test the stability of the results.</p><p><strong>Results: </strong>The risk of developing GSD increased in the Quartiles 2, 3, and 4 compared with Quartile 1 of TyG index (adjusted HR [aHR] 1.570 [95%CI 1.303-1.893], 1.577 [1.295-1.920], 1.489 [1.181-1.878], P_trend < 0.001 across quartiles of TyG index). The aHR for every unit and SD increment in TyG index were 1.282 [1.100-1.494], 1.151 [1.055-1.256]. The results were consistent when participants who developed GSD in the first year of follow-up were excluded. The restricted cubic spline regression also showed an increased risk of GSD with increasing TyG index.</p><p><strong>Conclusions: </strong>Increased TyG index is associated with an elevated risk of GSD. The TyG index might be an important indicator for identifying people at high risk of GSD.</p>","PeriodicalId":15877,"journal":{"name":"Journal of Gastroenterology and Hepatology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142791950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}