Journal of Gastroenterology and Hepatology最新文献

{"title":"Reply to Letter to the Editor About the Article \"GLP-1 RA Plus SGLT2i Versus Monotherapy in MASLD and Type 2 Diabetes: Three Pairwise Target Trial Emulations\".","authors":"Mohanad A Alkuwaiti, Faisal A Al-Harbi, Ahmed K Alsaif, Ziyad M AlSughayyir, Rayan Saleh Alsaud, Mohammed N Aljabr, Ahmad K Alanazi, Ahmad A Alosaily, Abdulrhman K Alabdulqader, Hamza Almusabeh, Rayyan F Altemani, Ahmed Y Azzam","doi":"10.1111/jgh.70698","DOIUrl":"10.1111/jgh.70698","url":null,"abstract":"","PeriodicalId":15877,"journal":{"name":"Journal of Gastroenterology and Hepatology","volume":" ","pages":"3283-3284"},"PeriodicalIF":3.5,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148813111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to the Letter Regarding \"Methodological Considerations in Real-World Evaluation of Durvalumab Plus Tremelimumab for Unresectable Hepatocellular Carcinoma\".","authors":"Toshifumi Tada, Tomomitsu Matono, Takashi Kumada","doi":"10.1111/jgh.70674","DOIUrl":"10.1111/jgh.70674","url":null,"abstract":"","PeriodicalId":15877,"journal":{"name":"Journal of Gastroenterology and Hepatology","volume":" ","pages":"3248-3249"},"PeriodicalIF":3.5,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148794012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differences in the Plasma Bile Acid-Gut Microbiota Axis Between IBS-D and IBS-C","authors":"Yao Chengjiao,&nbsp;Zhang Zerui,&nbsp;Pu Mengjun,&nbsp;Liu Liming","doi":"10.1111/jgh.70669","DOIUrl":"10.1111/jgh.70669","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Irritable bowel syndrome with constipation (IBS-C) and diarrhea (IBS-D) exhibit highly divergent clinical manifestations. This study aims to investigate the correlation between IBS-C and IBS-D.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>All participants provided fecal samples and completed IBS-SSS, IBS-QOL, and GSRS. Fecal bacterial composition was analyzed via custom V4-region 16S rRNA amplicon sequencing on the Illumina NovaSeq 6000 platform, while bile acids were quantified using liquid chromatography–tandem mass spectrometry (LC–MS).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Key Results</h3>\u0000 \u0000 <p>Patients with IBS-D reported significantly higher frequency and severity of diarrhea and abdominal pain. Conversely, IBS-C patients experienced more severe bloating and constipation than IBS-D patients. Compared to HCs, total bile acids, primary bile acids, secondary bile acids, conjugated bile acids, and unconjugated bile acids were elevated in IBS-D but reduced in IBS-C. The gut microbiota composition of both IBS-D and IBS-C patients differed significantly from that of HCs. Differential species in the IBS-D group were primarily associated with Prevotella and Ruminococcaceae, those in the IBS-C group were mainly concentrated in Bacteroides and Clostridium, and differential species in the HCs group were primarily found in Ruminococcus. Abundances of Clostridiaceae and Bacteroides correlated negatively with plasma chenodeoxycholic acid and cholic acid, respectively, while Clostridium correlated negatively with ursodeoxycholic acid (UDCA). Ruminococcus correlated positively with isodeoxycholic acid.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Alterations in the bile acid–gut microbiota axis are closely related to the distinct clinical presentations of IBS-C and IBS-D. IBS-D is characterized by a decreased abundance of Ruminococcus and Clostridium, alongside increased bile acid secretion and reduced reabsorption, which primarily contribute to the observed differences.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15877,"journal":{"name":"Journal of Gastroenterology and Hepatology","volume":"41 10","pages":"3168-3179"},"PeriodicalIF":3.5,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148794100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The True Cost of Colonoscopy Training: Time, Not Quality.","authors":"Kennedy Edwards, Niamh Louwman, Sampath Kumar, Suneil A Raju","doi":"10.1111/jgh.70795","DOIUrl":"https://doi.org/10.1111/jgh.70795","url":null,"abstract":"","PeriodicalId":15877,"journal":{"name":"Journal of Gastroenterology and Hepatology","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149110820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond Technology Acceptance: Calibrating Risk Perception in AI-Assisted Endoscopy","authors":"Yawei Li,&nbsp;Dun Wan,&nbsp;Yi Ding","doi":"10.1111/jgh.70564","DOIUrl":"10.1111/jgh.70564","url":null,"abstract":"","PeriodicalId":15877,"journal":{"name":"Journal of Gastroenterology and Hepatology","volume":"41 10","pages":"3224-3225"},"PeriodicalIF":3.5,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148900696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of Aspirin With Improved Clinical Outcomes and Survival in Patients With Compensated Cirrhosis: A Propensity Score-Matched Study of 25 782 Individuals.","authors":"Shahem Abbarh, Bisher Sawaf, Tiago Lemos Cerqueira, Hagen B Huttner, Annahita Sedghi, Norma J Diel, Timo Siepmann","doi":"10.1111/jgh.70780","DOIUrl":"https://doi.org/10.1111/jgh.70780","url":null,"abstract":"<p><strong>Background: </strong>Pharmacologic therapies to prevent decompensation in cirrhosis remain limited.</p><p><strong>Aim: </strong>To evaluate the association between aspirin use and cirrhosis-related outcomes and mortality.</p><p><strong>Methods: </strong>This retrospective cohort study utilized deidentified electronic health records from a global federated network (January 2013-July 2025). Adults with cirrhosis without decompensation in the preceding 12 months and without prior HCC were included. Following 1:1 propensity score matching, outcomes were assessed at 12, 24, and 36 months. The primary outcome was a composite of cirrhosis-related decompensation (ascites, spontaneous bacterial peritonitis, variceal bleeding, hepatorenal syndrome, encephalopathy). Secondary outcomes included hepatocellular carcinoma (HCC), mortality, and gastrointestinal bleeding.</p><p><strong>Results: </strong>Among 458 165 patients, matching yielded 25 782 patients (12 891 per group; mean age 63.3 years). Aspirin was associated with a lower risk of the composite outcome at 12 (HR, 0.75; 95% CI, 0.67-0.83), 24 (HR, 0.76; 95% CI, 0.70-0.84), and 36 months (HR, 0.77; 95% CI, 0.68-0.84), driven by reduced variceal bleeding, spontaneous bacterial peritonitis, and ascites. Absolute risks were 17.8% vs. 22.7% at 12 months, 20.4% vs. 24.7% at 24 months, and 22.0% vs. 25.7% at 36 months. At 12 months, the NNT was 21 for the composite outcome and 20 for mortality. Despite an increased risk of nonvariceal bleeding (NNH 143 at 12 months), serving as a positive control outcome, aspirin demonstrated a net clinical benefit, with more pronounced benefits in high cardiovascular risk patients (p_interaction < 0.05).</p><p><strong>Conclusions: </strong>Aspirin use is associated with reduced cirrhosis complications, HCC, and mortality, suggesting a potential role in the management of compensated cirrhosis.</p>","PeriodicalId":15877,"journal":{"name":"Journal of Gastroenterology and Hepatology","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149110843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on \"Does Local Excision Without Salvage Surgery Affect the Prognostic Outcome of Patients With Malignant Colorectal Polyp? A Long-Term Survival Analysis\".","authors":"Shehzadi Malaika Munsif, Abdullah Ayoob, Wajeeha Mushtaque, Shahzeela Imtiaz, Noor Un Nisa","doi":"10.1111/jgh.70693","DOIUrl":"10.1111/jgh.70693","url":null,"abstract":"","PeriodicalId":15877,"journal":{"name":"Journal of Gastroenterology and Hepatology","volume":" ","pages":"3272-3273"},"PeriodicalIF":3.5,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148813144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combination GLP-1 RA Plus SGLT2i Therapy in MASLD and Type 2 Diabetes: Methodological Considerations for the Three Pairwise Target Trial Emulations.","authors":"Rohma Zubairi","doi":"10.1111/jgh.70703","DOIUrl":"10.1111/jgh.70703","url":null,"abstract":"","PeriodicalId":15877,"journal":{"name":"Journal of Gastroenterology and Hepatology","volume":" ","pages":"3293-3294"},"PeriodicalIF":3.5,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148813097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond Fibrosis: Rethinking Therapeutic Success and Generalizability in MASLD.","authors":"Abubakar Siddique, Muhammad Moawya Nawab, Muhammad Jameel, Dur E Najaf","doi":"10.1111/jgh.70707","DOIUrl":"10.1111/jgh.70707","url":null,"abstract":"","PeriodicalId":15877,"journal":{"name":"Journal of Gastroenterology and Hepatology","volume":" ","pages":"3297-3298"},"PeriodicalIF":3.5,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148850846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on: \"Efficacy and Safety of Tegoprazan-Amoxicillin Dual Therapy for Helicobacter pylori Eradication: A Systematic Review and Meta-Analysis With Trial Sequential Analysis of Randomized Controlled Trials\".","authors":"Warsha Jeswani, Aartee Kumari Jeswani","doi":"10.1111/jgh.70725","DOIUrl":"10.1111/jgh.70725","url":null,"abstract":"","PeriodicalId":15877,"journal":{"name":"Journal of Gastroenterology and Hepatology","volume":" ","pages":"3321-3322"},"PeriodicalIF":3.5,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148891677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}