Journal of Gastroenterology and Hepatology最新文献

{"title":"Second Examination of the Right Colon Using Narrow-Band Imaging Increases Adenoma Detection Rates in the Right Colon: A Multicenter, Randomized Controlled Trial.","authors":"Shin Hee Kim, One Zoong Kim, In Kyung Yoo, Jae Yong Park, Young Joo Yang, Jin Hwa Park, Sang Pyo Lee, Jae Gon Lee","doi":"10.1111/jgh.16964","DOIUrl":"https://doi.org/10.1111/jgh.16964","url":null,"abstract":"<p><strong>Background/aims: </strong>Repeat examination of the right colon increases adenoma detection rates (ADRs) in the right colon. This study aimed to investigate whether a second examination of the right colon using narrow-band imaging (NBI) increases ADRs in the right colon compared with repeat examinations using white light imaging (WLI).</p><p><strong>Methods: </strong>Consecutive patients with routine indications for colonoscopy were enrolled and randomly assigned to two groups. The control arm underwent two repeat forward examinations of the right colon using WLI only (repeat-WLI group), and the intervention arm underwent the first examination of the right colon using WLI and the second examination using NBI (WLI-NBI group). Lesions detected during the first and second examinations in each group were analyzed. The primary outcome was ADR in the right colon.</p><p><strong>Results: </strong>A total of 476 colonoscopies were analyzed, including 240 and 236 in the repeat-WLI and WLI-NBI groups, respectively. The overall ADR in the right colon was significantly higher in the WLI-NBI group than that in the repeat-WLI group (27.1% vs. 17.9%; p = 0.022). The number of adenomas per colonoscopy in the right colon was also significantly higher in the WLI-NBI group than in the repeat-WLI group (mean number of adenomas, 0.36 vs. 0.24; p = 0.042). However, there were no significant differences in the detection rates of advanced adenomas and sessile serrated lesions between the WLI-NBI and repeat-WLI groups (advanced adenoma, 4.7% vs. 2.9%; sessile serrated lesion, 2.5% vs. 3.3%).</p><p><strong>Conclusion: </strong>A second forward examination of the right colon using NBI increased ADRs in the right colon.</p>","PeriodicalId":15877,"journal":{"name":"Journal of Gastroenterology and Hepatology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143988463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of an AI-Assisted System for Automatic Recognition and Localization Marking of Colonic Polyps (With Video).","authors":"Jian Chen, Ganhong Wang, Yu Ding, Zihao Zhang, Kaijian Xia, Lu Xu, Xiaodan Xu","doi":"10.1111/jgh.16980","DOIUrl":"https://doi.org/10.1111/jgh.16980","url":null,"abstract":"<p><strong>Background: </strong>Localizing colorectal polyps identified during the initial colonoscopy in minimally invasive endoscopic surgery presents significant challenges. These challenges include imprecise location descriptions, unclear images, a high number of polyps, and polyp characteristics such as flat shapes and low color contrast. To address these issues, we developed an AI-assisted system for the automatic detection and localization of colorectal polyps.</p><p><strong>Methods: </strong>Colonic images and videos from three medical centers, collected between January 2018 and August 2024, were categorized based on pathology results into normal, adenomatous polyp, and serrated lesion groups. Transfer learning and fine-tuning were conducted on five pretrained CNN models, with performance evaluated using metrics such as accuracy, precision, sensitivity, and AUC. The best-performing model was selected for interpretability analysis and developed into an AI-assisted system capable of both polyp recognition and location marking.</p><p><strong>Results: </strong>Among the five models, EfficientNetV2 performed the best, achieving accuracy, precision, sensitivity, and F1 scores of 0.933, 0.917, 0.916, and 0.917, respectively, on the validation set. On the test set, the model's overall weighted average precision, specificity, and AUC were 0.903, 0.946, and 0.983, respectively. Two representative colonoscopy case videos predicted by the model further demonstrated the feasibility of this AI system in clinical practice.</p><p><strong>Conclusions: </strong>The AI system we developed for the automatic recognition and localization marking of colonic polyps in colonoscopy aids in the rapid localization of polyps during minimally invasive endoscopic surgery.</p>","PeriodicalId":15877,"journal":{"name":"Journal of Gastroenterology and Hepatology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143988562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gender Parity in Authorship of Gastroenterology Publications: Some Way yet Over the Horizon","authors":"Sundramoorthy Mahendra Raj,&nbsp;Sharmila Sachithanandan","doi":"10.1111/jgh.16981","DOIUrl":"10.1111/jgh.16981","url":null,"abstract":"&lt;p&gt;It is poignant that as the Trump administration in the United States dials back on policies effecting diversity, equity, and inclusion (DEI) [&lt;span&gt;1&lt;/span&gt;], this issue of the journal carries a paper by Ng et al. that examined gender disparity in the authorship of Gastroenterology Clinical Practice Guidelines in the United States [&lt;span&gt;2&lt;/span&gt;]. The key finding was that in 2019–2022, men outnumbered women as first authors of guidelines by 3 to 1, and as senior authors by more than 5 to 1. Even more telling was that when compared to retired guidelines on the same topics, female author representation had not improved between 2010 and 2020. Furthermore, the overwhelming majority of male first and senior authors held the faculty rank of professor in stark contrast to female authors among whom only a minority were professors. A marginally brighter picture emerged when the authorship of articles cited in the guidelines was analyzed. Between 1980 and 2020, there was an increase in the number of cited articles with women as first and senior authors, perhaps simply a reflection of the overall proliferation of research publications over time. However, while women still constituted a minority of first and senior authors, there was an encouraging increase in female representation over the period. A closer look at the data on cited articles gives more insight into the publication landscape. Women were even more underrepresented as first or senior authors in cited articles that were randomized controlled trials, systemic reviews or meta-analyses than of articles that were observational studies. As an extension of that, cited articles of which women were first or senior authors were much less likely to support a strong recommendation than articles authored by men. First and senior female authors of cited articles were again substantially less likely to hold the faculty rank of professor than their male counterparts.&lt;/p&gt;&lt;p&gt;While a similar study in the Asia Pacific region has not been conducted, it is more than likely that the gender disparity would be even more pronounced. There is already data showing that female participation as speakers, chairpersons, and organizing committee members of gastroenterology, hepatology, and endoscopy conferences in Asia is low [&lt;span&gt;3&lt;/span&gt;].&lt;/p&gt;&lt;p&gt;Twenty-five years after the turn of the century, it seems anachronistic to have to argue the case for greater participation of women. Sadly, the lack of progress in many parts of the world and indeed regression in some parts, makes it important to revisit some of the arguments for greater female involvement. Moral and ethical considerations aside, there is compelling evidence from the business world that greater gender diversity among company leadership teams is associated with higher performance [&lt;span&gt;4&lt;/span&gt;]. A recent study showed that patients treated by female physicians had lower mortality and readmission rates, an effect even more noticeable among female patients [&lt;spa","PeriodicalId":15877,"journal":{"name":"Journal of Gastroenterology and Hepatology","volume":"40 6","pages":"1339-1341"},"PeriodicalIF":3.7,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jgh.16981","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144012534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Use of Aspirin Increased the Adenoma Detection Rate and Positive Predictive Value of Fecal Immunochemical Test","authors":"Zhongxue Han,&nbsp;Ruchen Zhou,&nbsp;Yueyue Li,&nbsp;Yanqing Li","doi":"10.1111/jgh.16949","DOIUrl":"10.1111/jgh.16949","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background and Aim</h3>\u0000 \u0000 <p>We aim to evaluate the effect of aspirin on fecal immunochemical test (FIT) performance for advanced colorectal neoplasia (ACRN) including advanced adenoma (AA) and colorectal cancer (CRC).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A multicenter study involved 4887 individuals who were asked to complete a quantitative FIT and subsequent colonoscopy. Aspirin users and nonusers were matched for age and sex. The primary outcome was the positive predictive value (PPV) of FIT compared between users and matched nonusers. Univariable and multivariable logistic regression analyses were also conducted in the entire cohort and expressed as odds ratio (OR) with 95% confidence interval (CI).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>For AA, the PPV of FIT was 25.30% in users vs. 14.71% in nonusers (<i>p</i> = 0.005), and the detection rate was 8.28% in users vs. 4.44% in nonusers (<i>p</i> = 0.003). The multivariable OR after adjusting age and sex was 1.52 (95% CI, 1.02–2.22, <i>p</i> = 0.036) for PPV and 1.41 (95% CI, 0.99–1.99, <i>p</i> = 0.052) for the detection rate compared between users and nonusers. Aspirin did not affect the sensitivity and specificity of FIT for AA. Additionally, no significant difference in FIT performance for ACRN and CRC was observed.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The use of aspirin increased detection rate and PPV of FIT for AA, without impact on FIT performance for ACRN and CRC. Given the risk of cardiovascular events and influence on participation rate of FIT screening, aspirin withdrawal before FIT is unnecessary.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15877,"journal":{"name":"Journal of Gastroenterology and Hepatology","volume":"40 6","pages":"1461-1471"},"PeriodicalIF":3.7,"publicationDate":"2025-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144029309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"AI-Assisted Reading in Small-Bowel Capsule Endoscopy: Are We Ready for Prime Time?","authors":"Pablo Cortegoso Valdivia,&nbsp;Noemi Gualandi,&nbsp;Ervin Toth,&nbsp;Anastasios Koulaouzidis","doi":"10.1111/jgh.16968","DOIUrl":"10.1111/jgh.16968","url":null,"abstract":"","PeriodicalId":15877,"journal":{"name":"Journal of Gastroenterology and Hepatology","volume":"40 6","pages":"1633-1634"},"PeriodicalIF":3.7,"publicationDate":"2025-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143983639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to “PLK2 Inhibited Oxidative Stress and Ameliorated Hepatic Ischemia–Reperfusion Injury Through Phosphorylating GSK3β”","authors":"","doi":"10.1111/jgh.16966","DOIUrl":"https://doi.org/10.1111/jgh.16966","url":null,"abstract":"<p>\u0000 <span>W. Ge</span>, <span>Z. Wang</span>, <span>X. Zhong</span>, et al., “ <span>PLK2 Inhibited Oxidative Stress and Ameliorated Hepatic Ischemia–Reperfusion Injury Through Phosphorylating GSK3β</span>,” <i>Journal of Gastroenterology and Hepatology</i> <span>40</span>, no. <span>1</span> (<span>2025</span>): <span>304</span>–<span>314</span>, https://doi.org/10.1111/jgh.16815.</p><p>An author affiliation was missed out, and the symbol linked to the first author affiliation is incorrect.</p><p>Additionally, the affiliations for the co-author, Kai Wang, should include both “Zhejiang University School of Medicine, Hangzhou, China” and “Department of Hepatobiliary &amp; Pancreatic Surgery and Minimally Invasive Surgery, Zhejiang Provincial People's Hospital (Affiliated People's Hospital), School of Clinical Medicine, Hangzhou Medical College, Hangzhou 310 024, Zhejiang, China.”</p><p>The correct author and affiliation lists are displayed below:</p><p>Wenwen Ge*, Zhoucheng Wang*, Xinyang Zhong*, Yutong Chen^†, Xiao Tang*, Shusen Zheng^‡,§, Xiao Xu^‡,¶,**, and Kai Wang^*,¶</p><p>*Zhejiang University School of Medicine, †The Fourth School of Clinical Medicine, Zhejiang Chinese Medical University, ‡NHC Key Laboratory of Combined Multi-Organ Transplantation, Zhejiang University, §Department of Hepatobiliary and Pancreatic Surgery, Shulan (Hangzhou) Hospital, ¶Department of Hepatobiliary and Pancreatic Surgery and Minimally Invasive Surgery, Zhejiang Provincial People's Hospital (Affiliated People's Hospital), School of Clinical Medicine, Hangzhou Medical College, Hangzhou, China **Institute of Translational Medicine, Zhejiang University School of Medicine.</p><p>We apologize for this error.</p>","PeriodicalId":15877,"journal":{"name":"Journal of Gastroenterology and Hepatology","volume":"40 5","pages":"1333"},"PeriodicalIF":3.7,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jgh.16966","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143925832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Remarks on Colonic Diverticulosis and Uncomplicated Diverticulitis Are Associated With Lower Not Higher Risk of Mortality","authors":"Sohaib Raza,&nbsp;Soban Ahmed Qureshi,&nbsp;Muzzamil Ahmed,&nbsp;Muhammad Adnan,&nbsp;Shah Rukh Rehman","doi":"10.1111/jgh.16971","DOIUrl":"10.1111/jgh.16971","url":null,"abstract":"","PeriodicalId":15877,"journal":{"name":"Journal of Gastroenterology and Hepatology","volume":"40 6","pages":"1640-1641"},"PeriodicalIF":3.7,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143986089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nonlinear Trend and Inequality Analysis of Colorectal Cancer Burden From 1990 to 2021: Insights From the Global Burden of Disease Study 2021","authors":"Yunduo Zhou,&nbsp;Ruilong Hao","doi":"10.1111/jgh.16976","DOIUrl":"10.1111/jgh.16976","url":null,"abstract":"","PeriodicalId":15877,"journal":{"name":"Journal of Gastroenterology and Hepatology","volume":"40 6","pages":"1642-1643"},"PeriodicalIF":3.7,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144027934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hereditary Gastrointestinal Cancer Syndromes and Early-Onset Gastrointestinal Cancers","authors":"Rashid N. Lui,&nbsp;Han-Mo Chiu","doi":"10.1111/jgh.16965","DOIUrl":"https://doi.org/10.1111/jgh.16965","url":null,"abstract":"&lt;p&gt;Gastroenterologists are frequently at the forefront of patient care for patients with hereditary gastrointestinal (GI) cancer syndromes. Familiarity to the main hereditary colorectal cancer (HCRC) syndromes such as Lynch syndrome (LS) and familial adenomatous polyposis (FAP) and understanding the genotype/phenotype relationship are paramount for recommending personalized management and surveillance. Furthermore, it would be considered good practice to refer patients and family members to dedicated cancer genetic services for genetic counseling, address specific concerns associated with each genetic susceptibility, and for cascade testing if appropriate [&lt;span&gt;1&lt;/span&gt;].&lt;/p&gt;&lt;p&gt;In recent issues of the &lt;i&gt;Journal of Gastroenterology and Hepatology&lt;/i&gt;, several studies have been published that shed further light on hereditary GI cancer syndromes. First, lifestyle and environmental risk factors still play an important role in disease burden for this patient group. A Korean study found that apart from high baseline polyp burden of &gt; 100 polyps and specific genetic mutations, exposure to smoking independently predicted a high risk of increased polyp burden in patients with suspected polyposis syndrome. A similar finding was found for patients with LS where patients who smoked had CRC at a younger age, and heavy drinkers had a high risk of CRC and any cancer [&lt;span&gt;2&lt;/span&gt;]. This suggests that lifestyle modification such as smoking cessation and alcohol abstinence not only reduces the risk of sporadic CRC but may also play a prominent role in reducing the risk of HCRC. Second, there are some differences in the cancer surveillance guidelines for LS that may cause confusion and difficulty for clinicians. This includes the age to begin CRC screening, recommendations on gynecological surveillance and modalities, urological surveillance, recommendations for surgery, and chemoprophylaxis strategies [&lt;span&gt;3&lt;/span&gt;]. Third, the prevalence and incidence of Peutz–Jeghers syndrome (PJS) and juvenile polyposis syndrome (JPS) in Japan were determined for the first time. In 2021, the prevalence of PJS and JPS were 0.6/100000 and 0.15/100000, respectively, and the incidence of PJS and JPS were 0.07/100000 and 0.02/100000, respectively [&lt;span&gt;4&lt;/span&gt;]. In Korean polyposis patients (≥ 10 biopsy-proven cumulative polyps) but without germline mutations for known HCRC syndromes, genome-wide association studies revealed 71 novel risk single-nucleotide polymorphisms (SNPs). Two novel genes (&lt;i&gt;CNTN4&lt;/i&gt; and &lt;i&gt;CNTNAP3B&lt;/i&gt;) were identified, and three SNPs (rs149368557, rs12438834, and rs9707935) were associated with a higher risk of polyposis recurrence [&lt;span&gt;5&lt;/span&gt;]. This implies that ethnic and regional variations may exist and emphasizes the importance of identifying the polygenic risk profile of these low to medium penetrant genes and their cumulative effects on the risk of CRC.&lt;/p&gt;&lt;p&gt;Moving on to sporadic GI cancers, there has been a plethora of studies that ","PeriodicalId":15877,"journal":{"name":"Journal of Gastroenterology and Hepatology","volume":"40 5","pages":"1037-1039"},"PeriodicalIF":3.7,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jgh.16965","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143926063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Strengthening Predictive Models and Risk Assessment in Autoimmune Gastritis: A Critical Appraisal","authors":"Eisha Abid,&nbsp;Areeba Abid,&nbsp;Hiba Abid,&nbsp;Syed Ibad Hussain,&nbsp;Amna Amir Jalal","doi":"10.1111/jgh.16967","DOIUrl":"10.1111/jgh.16967","url":null,"abstract":"","PeriodicalId":15877,"journal":{"name":"Journal of Gastroenterology and Hepatology","volume":"40 6","pages":"1631-1632"},"PeriodicalIF":3.7,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144013659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}