Global Epidemiology of Early-Onset Digestive System Malignancy: A Systematic Analysis for the Global Burden of Disease Study 2021

IF 3.7 3区医学 Q2 GASTROENTEROLOGY & HEPATOLOGY

Journal of Gastroenterology and Hepatology Pub Date : 2025-05-22 DOI:10.1111/jgh.17012

Jiayi Wang, Deming Li, Fangzhou Ye, Jian Li, Zhe Qing, Xiaohong Zhang, Huanqing Li, Li Feng

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引用次数: 0

Abstract

Background and Aim

The researches on the global burden of digestive system malignancy in young populations were limited. This study aimed to comprehensively investigate the burden of early-onset digestive system malignancy (often defined as cancers diagnosed below the age of 50) based on the Global Burden of Disease 2021.

Methods

Data of incidence, prevalence, deaths, disability-adjusted life years (DALYs), and risk factors for the five major early-onset digestive system malignancies, including early-onset esophageal cancer (EOEC), early-onset gastric cancer (EOGC), early-onset liver cancer (EOLC), early-onset pancreatic cancer (EOPC), and early-onset colorectal cancer (EOCRC), were extracted from GBD 2021. The average annual percent change (AAPC) was calculated using joinpoint regression analysis. The Bayesian age–period–cohort (BAPC) model was utilized to predict the burden up to 2030.

Results

From 1990 to 2021, the age-standardized incidence rate (ASIR) of early-onset digestive system malignancies, except for EOCRC (AAPC, 0.37), showed a decreasing pattern. Meanwhile, the age-standardized mortality rate (ASMR) and age-standardized DALYs rate (ASDR) of early-onset digestive system malignancy presented a downward trend. Notably, high-middle sociodemographic index (SDI) countries experienced higher disease burdens. Dietary risk factors, tobacco, alcohol consumption, and metabolic factors were the main risk factors. The ASIR of EOEC and EOCRC was projected to increase in 2030, whereas the trend for EOGC, EOLC, and EOPC was projected to decrease.

Conclusions

Early-onset digestive system malignancy presented notable heterogeneity across gender, geography, and cancer types. This emphasizes the urgency of addressing the public health challenge of early-onset digestive system malignancy.

查看原文本刊更多论文

早发性消化系统恶性肿瘤的全球流行病学：全球疾病负担研究2021的系统分析。

背景与目的：关于全球年轻人群消化系统恶性肿瘤负担的研究有限。本研究旨在全面调查基于2021年全球疾病负担的早发性消化系统恶性肿瘤（通常定义为50岁以下诊断的癌症）的负担。方法：从GBD 2021中提取早发性食管癌（EOEC）、早发性胃癌（EOGC）、早发性肝癌（EOLC）、早发性胰腺癌（EOPC）、早发性结直肠癌（EOCRC）等5种主要早发性消化系统恶性肿瘤的发病率、患病率、死亡、残疾调整生命年（DALYs）及危险因素数据。采用结合点回归分析计算年均变化百分数（AAPC）。使用贝叶斯年龄-时期-队列（BAPC）模型预测到2030年的负担。结果：1990 - 2021年，除EOCRC （AAPC, 0.37）外，早发性消化系统恶性肿瘤的年龄标准化发病率（ASIR）呈下降趋势。同时，早发性消化系统恶性肿瘤的年龄标准化死亡率（ASMR）和年龄标准化DALYs率（ASDR）呈下降趋势。值得注意的是，中高社会人口指数（SDI）国家的疾病负担较高。饮食危险因素、吸烟、饮酒和代谢因素是主要的危险因素。预计2030年EOEC和EOCRC的ASIR将增加，而EOGC、EOLC和EOPC的ASIR将减少。结论：早发性消化系统恶性肿瘤在性别、地域和癌症类型上存在显著的异质性。这强调了解决早发性消化系统恶性肿瘤这一公共卫生挑战的紧迫性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Gastroenterology and Hepatology 医学-胃肠肝病学

CiteScore

7.90

自引率

2.40%

发文量

326

审稿时长

2.3 months

期刊介绍： Journal of Gastroenterology and Hepatology is produced 12 times per year and publishes peer-reviewed original papers, reviews and editorials concerned with clinical practice and research in the fields of hepatology, gastroenterology and endoscopy. Papers cover the medical, radiological, pathological, biochemical, physiological and historical aspects of the subject areas. All submitted papers are reviewed by at least two referees expert in the field of the submitted paper.