{"title":"ERCP-Based Cell Block: A Potential One-Stop Shop in the Management of Malignant Biliary Obstruction.","authors":"Rareș Crăciun, Andrada Seicean, Cristina Pojoga, Roxana Popa, Bobe Petrushev, Marcel Tanțău, Cristian Tefas","doi":"10.1111/jgh.70014","DOIUrl":"https://doi.org/10.1111/jgh.70014","url":null,"abstract":"<p><strong>Background and aim: </strong>Malignant biliary obstruction (MBO) typically results from cancers like pancreatic adenocarcinoma, cholangiocarcinoma, and gallbladder carcinoma, and it often presents at an advanced stage. Diagnostic tools such as ERCP and EUS-FNA are commonly used for tissue sampling, but each has limitations regarding accuracy and cost. This study aimed to compare the diagnostic accuracy and cost-effectiveness of cell block (CB) cytology collected during ERCP-guided stenting with the traditional EUS-FNA plus ERCP-guided stenting approach in patients with unresectable MBO.</p><p><strong>Methods: </strong>This prospective observational study included 102 patients with advanced unresectable MBO who underwent both EUS-FNA and ERCP-guided stenting with CB sampling. The study evaluated the diagnostic yield of three strategies: CB alone, EUS-FNA alone, and a combination of both methods. A cost-effectiveness analysis was conducted using publicly available reimbursement rates from the public healthcare system to assess potential procedural cost savings.</p><p><strong>Results: </strong>The diagnostic yield for EUS-FNA (82.35%) was higher than for CB (72.54%), though the difference was not statistically significant (p = 0.23). Combining both methods increased the diagnostic yield to 93.13% (p = 0.04). CB performed better in cases with direct biliary invasion (88.23% vs. 79.41% for EUS-FNA, p = 0.01). A cost reduction of 319.17 € per case was achieved using a CB-only strategy in appropriate cases.</p><p><strong>Conclusions: </strong>EUS-FNA remains superior for diagnosing extrinsic MBO, but ERCP-based CB offers a cost-effective and reliable diagnostic option, particularly for biliary tract cancers. The combination of both approaches enhances diagnostic accuracy, supporting their concurrent use in specific clinical scenarios, while optimizing costs.</p>","PeriodicalId":15877,"journal":{"name":"Journal of Gastroenterology and Hepatology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144659374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Cong Zhang, Yong-Wen Ouyang, Hui-Xin He, Pei-Zhu Su, Zhao-Tao Li
{"title":"The Emerging Role of CCL17 in the Immunologic Regulation of Inflammatory Bowel Disease.","authors":"Cong Zhang, Yong-Wen Ouyang, Hui-Xin He, Pei-Zhu Su, Zhao-Tao Li","doi":"10.1111/jgh.70005","DOIUrl":"https://doi.org/10.1111/jgh.70005","url":null,"abstract":"<p><p>Chemokine (C-C) ligand 17 (CCL17) is a key molecule that mediates immune cell migration and inflammation. As a ligand for the type 4 C-C chemokine receptor (CCR4), CCL17 mainly affects T cells, but also influences other cell types, suggesting a broader role in immune regulation. This review comprehensively demonstrates the molecular structure and function of CCL17, its interaction with CCR4, and its involvement in the pathogenesis of inflammatory bowel disease (IBD). Additionally, we also discuss how CCL17 regulates the behavior of various immune cells, including T cells, dendritic cells, monocytes/macrophages, eosinophils, neutrophils, and fibroblasts, highlighting its involvement in the pathogenesis of IBD and its potential contribution to IBD-related colon cancer. In conclusion, this review emphasizes the important role of CCL17 in the pathogenesis of IBD and its potential as a therapeutic target.</p>","PeriodicalId":15877,"journal":{"name":"Journal of Gastroenterology and Hepatology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144659376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Javier Tejedor-Tejada, Laura Sanchez-Sanmamed, Benito Hermida, Deepak Madhu, Rui Morais, Sónia Barros, Krzysztof Kurek, Ulrike Beilenhoff, Abdelaleem Helal, Alan Ovalle, Jose M Pérez-Pariente
{"title":"Ergonomics and Endoscopy-Related Injuries Among Endoscopists and Endoscopy Nurses. Results of International Multicenter Survey.","authors":"Javier Tejedor-Tejada, Laura Sanchez-Sanmamed, Benito Hermida, Deepak Madhu, Rui Morais, Sónia Barros, Krzysztof Kurek, Ulrike Beilenhoff, Abdelaleem Helal, Alan Ovalle, Jose M Pérez-Pariente","doi":"10.1111/jgh.70012","DOIUrl":"https://doi.org/10.1111/jgh.70012","url":null,"abstract":"<p><strong>Background and aim: </strong>The aim was to determine the prevalence, risk factors, and patterns of endoscopy-related injury (ERI) and the knowledge of ergonomics.</p><p><strong>Methods: </strong>A multicenter, international, cross-sectional study was conducted using a 21-item electronic survey to investigate ERI. The study included 484 (67.8%) endoscopists and 230 (32.2%) endoscopy nurses from 91 centers.</p><p><strong>Results: </strong>A total of 714 respondents (60.5% women, 93% right-handed, median age 40 years [IQR 33-48 years]) from 36 countries participated. Among them, 42.1% of endoscopists and 27.8% of nurses had > 10 years of experience performing endoscopy. ERI affecting at least one anatomic location was reported frequently by 70.1% of endoscopists and 87.8% of nurses (p < 0.001). Additionally, 87.1% of participants experienced pain in multiple areas. ERI was most common in the lower back (70% vs. 85.7%, p < 0.001) and the neck (62.4% vs. 74.3%, p = 0.001) among symptomatic endoscopists and nurses, respectively. Twenty-three percent of symptomatic respondents had modified their endoscopic practice. Among symptomatic respondents, 33% had sought a medical consultation, and 12% had required sick leave. However, only 12.7% of participants reported previous formal ergonomics education. Female gender, level of experience, number of endoscopic procedures, use of one-piece lead aprons, and the profession of endoscopy nursing were identified as factors associated with the development of ERI.</p><p><strong>Conclusions: </strong>The prevalence of ERI among endoscopists and nurses was very high. The pattern and risk factors for ERI were similar between the two groups. Ergonomics and educational measures for the prevention and management of ERIs are necessary.</p>","PeriodicalId":15877,"journal":{"name":"Journal of Gastroenterology and Hepatology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144659375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Anett Rancz, Brigitta Teutsch, Mahmoud Obeidat, Anna Walter, Gergő Weidinger, Bálint Erőss, Péter Hegyi, Emese Mihály
{"title":"Risk Factors for Microscopic Colitis: A Systematic Review and Meta-Analysis.","authors":"Anett Rancz, Brigitta Teutsch, Mahmoud Obeidat, Anna Walter, Gergő Weidinger, Bálint Erőss, Péter Hegyi, Emese Mihály","doi":"10.1111/jgh.70007","DOIUrl":"https://doi.org/10.1111/jgh.70007","url":null,"abstract":"<p><strong>Background: </strong>Microscopic colitis (MC) is still an underdiagnosed disease due to its primarily histological appearance. We aimed to address the scarcity and inconsistency of data on MC risk factors.</p><p><strong>Methods: </strong>Our protocol was prospectively registered in PROSPERO (CRD42022286624). We systematically searched PubMed, Embase, and Cochrane from inception to January 6, 2025. Cohort, case-control, and cross-sectional studies were included. Controls were distinguished with or without a histopathological examination. We used the random-effect model to calculate pooled odds ratios (ORs) with 95% confidence intervals (CIs).</p><p><strong>Results: </strong>The systematic search yielded 6493 articles, of which 45 were meta-analyzed. We found increased odds for MC in the case of nonsteroidal anti-inflammatory drug (NSAID) and statin use compared to histological (OR = 2.57, CI: 1.45-4.53; OR = 2.15, CI: 1.14-4.05) and random (OR = 2.56, CI: 1.13-5.79; OR = 1.84, CI: 0.58-5.80) controls. Our results did not show an association between proton pump inhibitors (PPIs) and MC, compared to histological controls (OR = 1.81, CI: 0.75-4.35), except in the case of random controls (OR = 4.31, CI: 1.66-11.20). Neither current (OR = 1.35, CI: 0.88-2.06) nor previous smoking (OR = 1.26, CI: 0.67-2.39) increased the odds of MC compared to histological controls. In contrast, the odds doubled for current smoking and slightly changed for past smoking when MC patients were compared to random controls (OR = 2.40, CI: 1.64-3.50; OR = 1.11, CI: 0.93-1.31).</p><p><strong>Conclusions: </strong>NSAID and statin treatment were associated with an increased risk for MC compared to histological controls. PPIs and smoking showed only an association with MC when random controls were used.</p>","PeriodicalId":15877,"journal":{"name":"Journal of Gastroenterology and Hepatology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144649679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Helicobacter pylori Infection and Eradication in Relation to Gastroesophageal Reflux Disease.","authors":"Hejie Wang, Yaxin Qu, Yuan Lin, Zhiqiang Liu, Jesper Lagergren, Shuai Yuan, Eivind Ness-Jensen, Wei Jiang, Shao-Hua Xie","doi":"10.1111/jgh.70009","DOIUrl":"https://doi.org/10.1111/jgh.70009","url":null,"abstract":"<p><strong>Background and aim: </strong>The effect of Helicobacter pylori (H. pylori) infection and eradication on the risk of gastroesophageal reflux disease (GERD) is still unclear.</p><p><strong>Methods: </strong>We conducted a systematic review with a comprehensive literature search in the bibliographic databases Embase, Medline, and Cochrane Library through May 2024. Random-effects meta-analyses estimated the pooled odds ratios (OR) for the associations of H. pylori infection and eradication with GERD risk in prospective studies. A two-sample Mendelian randomization analysis based on data from the FinnGen study assessed associations between genetically predicted levels of seven H. pylori antibodies, that is, immunoglobulin G (IgG) and six virulence factors (cytotoxin-associated gene A [CagA], Outer Membrane Protein [OMP], vacuolating cytotoxin A [VacA], urease A [UreA], catalase and GroEL), and GERD risk.</p><p><strong>Results: </strong>A total of 24 eligible studies were included. Meta-analysis combining data from three cohort studies and one nested case-control study indicated an inverse association between H. pylori infection and GERD (pooled OR = 0.58; 95% confidence interval [CI], 0.23-1.44). Meta-analysis of 17 cohort studies and three randomized controlled trials (RCTs) showed an increased risk of GERD after H. pylori eradication (pooled OR = 2.01; 95% CI, 1.44-2.81), and this association was stronger when specifically analyzing reflux esophagitis (pooled OR = 2.27; 95% CI, 1.57-3.29). No associations were found in Mendelian randomization analysis for any of the studied H. pylori antibodies.</p><p><strong>Conclusions: </strong>The study suggests that H. pylori infection is associated with a decreased risk of GERD and that H. pylori eradication increases the risk.</p>","PeriodicalId":15877,"journal":{"name":"Journal of Gastroenterology and Hepatology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144637215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Tae Seung Lee, Young Hoon Choi, Jun Yeol Kim, Myeong Hwan Lee, Kyu-Hyun Paik, In Rae Cho, Woo Il Kwon, Sang Hyub Lee, In Seok Lee, Myung Ah Lee, Jin-Young Jang, Ji Kon Ryu, Yong-Tae Kim, Woo Hyun Paik
{"title":"Comparison of 5-Fluorouracil/Leucovorin and Capecitabine as Adjuvant Therapies in Biliary Tract Cancer.","authors":"Tae Seung Lee, Young Hoon Choi, Jun Yeol Kim, Myeong Hwan Lee, Kyu-Hyun Paik, In Rae Cho, Woo Il Kwon, Sang Hyub Lee, In Seok Lee, Myung Ah Lee, Jin-Young Jang, Ji Kon Ryu, Yong-Tae Kim, Woo Hyun Paik","doi":"10.1111/jgh.17044","DOIUrl":"https://doi.org/10.1111/jgh.17044","url":null,"abstract":"<p><strong>Background: </strong>The prognosis of biliary tract cancer (BTC) is poor, and recurrence rates remain high even after curative resection. This study aimed to compare the efficacy and safety of capecitabine and 5-fluorouracil/leucovorin (FL) as adjuvant treatments following curative resection in patients with BTC.</p><p><strong>Methods: </strong>We retrospectively reviewed the medical records of patients with BTC (including gallbladder and extrahepatic and intrahepatic bile duct cancers) who underwent curative surgical resection and adjuvant chemotherapy between 2011 and 2023. The recurrence-free survival, overall survival, and adverse events were investigated between the two groups.</p><p><strong>Results: </strong>Of the 263 patients, 85 and 178 received capecitabine and FL, respectively. The recurrence-free survival and overall survival did not show statistically significant differences between the capecitabine and FL groups. After propensity score matching, the capecitabine group showed significantly longer overall survival (median, NA [52 - NA] vs. 43 months [32 - NA], p = 0.032). Although severe adverse events did not differ between both groups (29.4% vs. 20.2%, p = 0.135), overall adverse events, including anemia, thrombocytopenia, hand-foot syndrome, and skin color change, were significantly more frequent in the capecitabine group (90.6% vs. 57.9%, p < 0.001). After propensity score matching, severe adverse events (30.3% vs. 14.5%, p = 0.032) and overall adverse events (90.8% vs. 65.8%, p < 0.001) were significantly more frequent in the capecitabine group.</p><p><strong>Conclusion: </strong>In patients with curatively resected BTC, capecitabine demonstrated superior efficacy in prolonging overall survival, whereas FL had a more favorable safety profile with fewer adverse events.</p>","PeriodicalId":15877,"journal":{"name":"Journal of Gastroenterology and Hepatology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144626525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Associations of Long-Term Night Shift Work With Incident Irritable Bowel Syndrome: A Population-Based Cohort Study.","authors":"Yuxin Yao, Xiaojie You, Shiyu Yang, Yujia Xie, Haoyu Yin, Bingxin Shang, Yu Jiang, Mingyue Xue, Jixuan Ma","doi":"10.1111/jgh.70002","DOIUrl":"https://doi.org/10.1111/jgh.70002","url":null,"abstract":"<p><strong>Background and aim: </strong>To explore the impact of long-term night shift work on the incidence of irritable bowel syndrome (IBS) and the underlying mechanism.</p><p><strong>Methods: </strong>This cohort study included 239 760 participants who were in paid employment or self-employed from the UK Biobank. The start date refers to the date when a participant joined the cohort between 2006 and 2010, whereas the end of follow-up was December 31, 2021. In-depth lifetime employment information was used to calculate the duration and frequency of night shifts. Low-grade inflammation index (INFLA score) was calculated from five circulating inflammatory biomarkers. Cox proportional hazard models were used to estimate the relationships between long-term night shifts and IBS risk.</p><p><strong>Results: </strong>An increasing trend of IBS incidence was observed from day workers to regular night shift workers. Compared to day workers, rarely/some night shift workers (HR 1.097, 95% CI 1.007-1.195) and usual/permanent night shift workers (HR 1.213, 95% CI 1.046-1.407) had a higher risk of IBS. INFLA score significantly mediated this association (mediation proportion 3.6%, p < 0.05). Workers with a longer duration (≥ 3 years) (HR 1.241, 95% CI 1.073-1.436) and a higher frequency of night shifts (> 7 shifts/month) (HR 1.248, 95% CI 1.045-1.491) also showed higher IBS risks.</p><p><strong>Conclusion: </strong>Night shift work, longer night shift duration, and higher night shift frequency were associated with higher risks of IBS. The potential underlying mechanism may be heightened low-grade inflammation.</p>","PeriodicalId":15877,"journal":{"name":"Journal of Gastroenterology and Hepatology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144618577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ke-Yi Guo, Li-Yun Ma, Zu-Qiang Liu, Li Wang, Pei-Rong Xu, Tao Tan, Xue-Feng Yan, Jian-Wei Hu, Ping-Hong Zhou, Hao Hu
{"title":"Endoscopic Sub-Stent Dissection for Removal of Long-Term Embedded Esophageal Self-Expanding Metallic Stents.","authors":"Ke-Yi Guo, Li-Yun Ma, Zu-Qiang Liu, Li Wang, Pei-Rong Xu, Tao Tan, Xue-Feng Yan, Jian-Wei Hu, Ping-Hong Zhou, Hao Hu","doi":"10.1111/jgh.17041","DOIUrl":"https://doi.org/10.1111/jgh.17041","url":null,"abstract":"<p><strong>Background and aim: </strong>Self-expanding metallic stents (SEMS) have been extensively applied to manage esophageal disorders. The hyperplastic mucosal tissue induced by the stent can provide a good anchoring function but also make the stent removal difficult, especially after long-term placement. Here, we report a new technique, endoscopic sub-stent dissection, for removing the long-term embedded SEMS and assessing its safety and efficacy.</p><p><strong>Methods: </strong>Patients with long-term embedded esophageal SEMS who underwent endoscopic sub-stent dissection between July 2018 and September 2024 were analyzed retrospectively. Demographic characteristics, procedure-related parameters, adverse events, and long-term outcomes were investigated.</p><p><strong>Results: </strong>A total of 16 patients with 17 embedded esophageal SEMS were included, where three patients had undergone a failed attempt using the stent-in-stent technique. Five patients (31.25%) were diagnosed with esophageal fistula, seven (43.75%) with stenosis, one (6.25%) with diverticulum, and three (18.75%) were placed for sealing the defects of endoscopic resection. Nine (52.94%) were partially covered SEMS (PCSEMS) and eight (47.06%) were fully covered SEMS (FCSEMS). The median stent retention time was 88.5 days (range, 28-1080). All embedded stents (100.0%) were successfully removed. The median procedure time was 26 min (range, 10-140). Procedure-related adverse events included one fever (6.25%) and one subcutaneous emphysema (6.25%). Three patients underwent outpatient surgery, and the median postoperative hospital stay was 3 days (range, 1-49).</p><p><strong>Conclusions: </strong>Endoscopic sub-stent dissection is relatively safe and effective for removing long-term embedded esophageal SEMS. Further study with a larger sample size is warranted.</p>","PeriodicalId":15877,"journal":{"name":"Journal of Gastroenterology and Hepatology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144608506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nicky E McCarthy, Michael Schultz, Catherine L Wall
{"title":"Role of the Dietitian in the Inflammatory Bowel Disease Multidisciplinary Team.","authors":"Nicky E McCarthy, Michael Schultz, Catherine L Wall","doi":"10.1111/jgh.70001","DOIUrl":"https://doi.org/10.1111/jgh.70001","url":null,"abstract":"<p><p>In recent years, nutrition and dietetics have evolved from playing a supporting role in inflammatory bowel disease care to becoming an integral part of the treatment approach. Nutrition and dietary treatments address malnutrition, which is known to be highly prevalent in inflammatory bowel disease patients, reduce active inflammation, provide symptom relief, and enhance quality of life. Patients believe that nutrition-based strategies are an important part of their disease management but generally have difficulty accessing specialist nutrition advice. Best practice inflammatory bowel disease management guidelines recommend coordinated multidisciplinary care models, but many multidisciplinary teams do not currently include dietitians. Research has shown that inflammatory bowel disease multidisciplinary teams that do include dietitians have improved patient disease outcomes and cost efficiencies. As the only health professional with extensive training in medical nutrition therapy and dietary counseling, dietitians are the most appropriate health professional to carry out detailed nutritional assessments and advise patients on individualized diet and nutrition treatments for inflammatory bowel disease. The growing emphasis on dietary therapy in inflammatory bowel disease and the complexity of evidence-based dietary recommendations highlight the need for dietitians to be an integral part of the multidisciplinary team caring for inflammatory bowel disease patients.</p>","PeriodicalId":15877,"journal":{"name":"Journal of Gastroenterology and Hepatology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144600652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Thomas Yuen Tung Lam, Yue Hu, Y Yi, Peter J Schulz, May O Lwin, Kalya M Kee, Wilson W B Goh, Max F K Cheung, H S Lee, Alice S H Fan, Phyllis P Y Lam, S F Lam, L Zhou, Y Chen, F Li, Ying Lau, Jer-Wei Wu, Han-Mo Chiu, H Xu, Joseph J Y Sung
{"title":"A Model Predicting Artificial Intelligence Use by Gastroenterology Nurses in Clinical Practice: A Cross-Sectional Multicenter Survey.","authors":"Thomas Yuen Tung Lam, Yue Hu, Y Yi, Peter J Schulz, May O Lwin, Kalya M Kee, Wilson W B Goh, Max F K Cheung, H S Lee, Alice S H Fan, Phyllis P Y Lam, S F Lam, L Zhou, Y Chen, F Li, Ying Lau, Jer-Wei Wu, Han-Mo Chiu, H Xu, Joseph J Y Sung","doi":"10.1111/jgh.17042","DOIUrl":"https://doi.org/10.1111/jgh.17042","url":null,"abstract":"<p><strong>Background and aims: </strong>Nurses' participation during colonoscopy has been demonstrated to significantly improve the detection rate of polyps and adenomas. Nonetheless, the adoption of AI in clinical practice still poses challenges. There is limited understanding of the factors influencing gastroenterology nurses' intentions to use AI in clinical practice. We aimed to examine how gastroenterology nurses' intentions to use AI are affected by perceived usefulness, acceptance of this technology, and perceived risk via a moderated mediation model controlling for nurses' characteristics.</p><p><strong>Methods: </strong>A cross-sectional multicenter survey study was conducted among gastroenterology nurses from 54 hospitals in Taiwan, Hong Kong, and mainland China. A total of 337 nurses (mean age 37.40 ± 8.29 years, 81.6% females) completed the survey.</p><p><strong>Results: </strong>After controlling for previous experience with AI, number of working years, and work role, a statistically significant direct effect of perceived usefulness on use intention was found. The indirect effect of perceived usefulness on use intention through AI technology acceptance was the most robust when perceived risk was at the lowest level.</p><p><strong>Conclusions: </strong>Findings suggest that perceived usefulness facilitated the intentional use of AI in clinical practice through acceptance of AI, especially when perceived risk was low.</p>","PeriodicalId":15877,"journal":{"name":"Journal of Gastroenterology and Hepatology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144560311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}