Journal of Gastroenterology and Hepatology最新文献

{"title":"IBD 2024: Charting a New Course in IBD Proceedings of the Takeda Symposium 22–23 November 2024 W Hotel, Brisbane, Queensland, Australia","authors":"Uma Mahadevan,&nbsp;Vipul Jairath,&nbsp;Jakob Begun,&nbsp;Aviv Pudipeddi,&nbsp;Mayur Garg,&nbsp;Peter De Cruz,&nbsp;Christopher F. D. Li Wai Suen,&nbsp;Matthew C. Choy,&nbsp;Danny Con,&nbsp;Rose Vaughan,&nbsp;John D. Chetwood,&nbsp;David A. Clark,&nbsp;Craig Haifer,&nbsp;Miles P. Sparrow,&nbsp;Rupert Leong,&nbsp;Réme Mountifield","doi":"10.1111/jgh.70020","DOIUrl":"https://doi.org/10.1111/jgh.70020","url":null,"abstract":"<p>The symposium <i>IBD 2024: Charting a New Course in IBD</i> was held in Brisbane, Australia, in November 2024. This was the fifth such meeting for the Australian inflammatory bowel disease (IBD) healthcare community. This symposium provided an overview of current and emerging management strategies for ulcerative colitis (UC) and Crohn's disease (CD). Key topic areas covered included the importance of treating to a minimum of endoscopic remission; important considerations for treatment choice, treatment switch, and treatment de-escalation; treatment during pregnancy; and emerging therapeutic options. This supplement provides a detailed summary of each of the symposium presentations, as well as key take-home messages.</p>","PeriodicalId":15877,"journal":{"name":"Journal of Gastroenterology and Hepatology","volume":"40 S3","pages":"3-22"},"PeriodicalIF":3.4,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jgh.70020","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145248446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comments on \"Twenty Years of Disease-Modifying Anti-IBD Drug Use Preceding Colectomy for Refractory IBD-Associated Colitis\".","authors":"Xianjie Zhu, Hongping Gu, Niansong Kang","doi":"10.1111/jgh.70104","DOIUrl":"https://doi.org/10.1111/jgh.70104","url":null,"abstract":"","PeriodicalId":15877,"journal":{"name":"Journal of Gastroenterology and Hepatology","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145251177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Amyloidosis for the Gastroenterologist: A Comprehensive Systematic Review of Diagnosis and Management of Gastrointestinal Manifestations.","authors":"Myo Jin Tang, Theng Yi Tay, Simon Gibbs, Ola Niewiadomski","doi":"10.1111/jgh.70083","DOIUrl":"https://doi.org/10.1111/jgh.70083","url":null,"abstract":"<p><strong>Background: </strong>Amyloidosis is a rare, multisystem disorder characterized by extracellular deposition of misfolded protein fibrils. Gastrointestinal (GI) amyloidosis is uncommon but under-recognized due to nonspecific symptoms, but early diagnosis is critical to improve quality of life and prognosis. This comprehensive systematic review aimed to summarize current literature on GI and hepatic manifestations of amyloidosis, highlighting diagnostic and management strategies across the major subtypes of amyloidosis, in particular AL (immunoglobulin light chain), ATTR (transthyretin), and AA (serum amyloid A) amyloidosis.</p><p><strong>Methods: </strong>A systematic search of MEDLINE, Embase, and PubMed conducted for studies published between January 2014 and December 2024 identified 77 studies meeting inclusion criteria.</p><p><strong>Results: </strong>GI symptoms occur in approximately 1 in 6 patients with amyloidosis, but symptoms correlate poorly with gastrointestinal deposition. Current literature suggests that duodenal biopsy is the most reliable diagnostic site. Fibroscan shows promise in detecting hepatic amyloid involvement. Management is subtype specific. However, supportive care, particularly nutritional intervention, is essential across all subtypes.</p><p><strong>Conclusions: </strong>GI amyloidosis presents diversely with nonspecific symptoms. Standardized diagnostic algorithms, targeted therapies, and nutritional support can lead to improved outcomes and enhance quality of life.</p>","PeriodicalId":15877,"journal":{"name":"Journal of Gastroenterology and Hepatology","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145244521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on \"Associations of Long-Term Night Shift Work With Incident Irritable Bowel Syndrome: A Population-Based Cohort Study\".","authors":"Ying Du, Hongjia Fan","doi":"10.1111/jgh.70113","DOIUrl":"https://doi.org/10.1111/jgh.70113","url":null,"abstract":"","PeriodicalId":15877,"journal":{"name":"Journal of Gastroenterology and Hepatology","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145244548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the Editor: Five-Year Effectiveness and Renal Safety Following Switching to Tenofovir Alafenamide in Chronic Hepatitis B Patients With Renal Impairment.","authors":"Zanzan Zhao, Wenhong Liu","doi":"10.1111/jgh.70105","DOIUrl":"https://doi.org/10.1111/jgh.70105","url":null,"abstract":"","PeriodicalId":15877,"journal":{"name":"Journal of Gastroenterology and Hepatology","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145244490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comments on Endoscopic Sub-Stent Dissection for Removal of Esophageal Self-Expanding Metallic Stents.","authors":"Sohaib Raza, Muhammad Adnan, Muhammad Saad Arshad, Abdul Rafay, Umer Majid Ullah","doi":"10.1111/jgh.70118","DOIUrl":"https://doi.org/10.1111/jgh.70118","url":null,"abstract":"","PeriodicalId":15877,"journal":{"name":"Journal of Gastroenterology and Hepatology","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145238881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Usefulness of Automated Analysis System for Microvascular Blood Flow Rate Using Magnifying Endoscopy in Early Gastric Cancer: A Multicenter Retrospective Study (With Video).","authors":"Yoichi Akazawa, Hiroya Ueyama, Shunsuke Nakamura, Yasuko Uemura, Tomoyo Iwano, Momoko Yamamoto, Hisanori Utsunomiya, Ryota Uchida, Daiki Abe, Shotaro Oki, Nobuyuki Suzuki, Atsushi Ikeda, Tsutomu Takeda, Kumiko Ueda, Mariko Hojo, Naoto Iwai, Osamu Dohi, Takehiro Iwasaki, Kunihisa Uchita, Shuko Nojiri, Takashi Yao, Akihito Nagahara","doi":"10.1111/jgh.70102","DOIUrl":"https://doi.org/10.1111/jgh.70102","url":null,"abstract":"<p><strong>Background and aim: </strong>Early gastric cancer (EGC) diagnosis after Helicobacter pylori eradication and differentiation from patchy redness (PR) remains challenging. We developed a novel automated analysis system for microvascular blood flow rate using magnifying endoscopy. This study evaluated its diagnostic performance in differentiating EGC from PR compared with endoscopists in a multicenter setting.</p><p><strong>Methods: </strong>We analyzed 76 magnifying endoscopy videos, including 36 EGCs and 40 PRs recorded at our institution. Lesions were diagnosed as cancer (EGC) or noncancer (PR) by the analysis system, based on the cut-off value calculated from the validation data set. Additionally, 30 endoscopists (15 experts and 15 trainees) from three institutions, all skilled in magnifying endoscopy diagnosis, participated. We compared the diagnostic performance between the analysis system and endoscopists.</p><p><strong>Results: </strong>Diagnostic accuracy, sensitivity, specificity, positive predictive value, and negative predictive value (NPV) were 84.2%, 86.1%, 82.5%, 81.6%, and 86.8%, respectively, for the analysis system, and 84.2%, 80.2%, 87.3%, 83.2%, and 84.9%, respectively, for the endoscopists. Sensitivity and NPV of the analysis system tended to be higher than those of endoscopists. Additionally, the accuracy of the analysis system was comparable to that of all endoscopists and tended to be superior to that of trainees (84.2% [95% CI: 74.0%-91.6%] vs. 81.7% [95% CI: 79.4%-83.8%], respectively).</p><p><strong>Conclusions: </strong>The automated analysis system for microvascular blood flow rate showed diagnostic performance equivalent to or superior to that of endoscopists skilled in magnifying endoscopy, suggesting its utility as a new diagnostic modality for differentiating EGC and PR in clinical practice.</p>","PeriodicalId":15877,"journal":{"name":"Journal of Gastroenterology and Hepatology","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145238890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"O-GlcNAcylation Facilitates the Initiation and Progression of Digestive Tumors.","authors":"Yan Xiong, Qiang Hu, Dan Li, Jiai Yan, Ju Yang, Yingyu Wang, Hong Cao, Yiran Liu, Yanping Xia, Feng Zhang, Jing Sun","doi":"10.1111/jgh.70093","DOIUrl":"https://doi.org/10.1111/jgh.70093","url":null,"abstract":"<p><p>The escalating global burden of digestive system cancers, marked by high morbidity, mortality, and drug resistance, necessitates a more profound understanding of the mechanisms underlying tumorigenesis. Accumulating evidence underscores the pivotal role of O-GlcNAcylation-a dynamic posttranslational modification-mediated by O-GlcNAc transferase (OGT)-in promoting digestive system tumors. Elevated levels of O-GlcNAcylation are intricately associated with tumor progression, metastasis, immune evasion, and chemotherapy resistance. Targeting OGT or its downstream effectors represents a promising strategy to overcome drug resistance and enhance therapeutic efficacy. This review innovatively integrates the core perspective of the metabolism-immune-epigenetics regulatory axis. Based on comprehensive preclinical and clinical evidence, it systematically elaborates on the translational potential of modulating O-GlcNAcylation in precision oncology for digestive system tumors, while emphasizing the necessity for future in-depth mechanistic studies and clinical validation.</p>","PeriodicalId":15877,"journal":{"name":"Journal of Gastroenterology and Hepatology","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145238904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing the Evaluation of Clinical Success in Malignant Gastric Outlet Obstruction.","authors":"Yusa Pan, Jianjun Ding","doi":"10.1111/jgh.70120","DOIUrl":"https://doi.org/10.1111/jgh.70120","url":null,"abstract":"","PeriodicalId":15877,"journal":{"name":"Journal of Gastroenterology and Hepatology","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145225447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating the Quality of Life in Gastric Cancer Survivors: Reflections on Jeon et al.'s Nationwide Study.","authors":"Shanza Arif, Rida Fatima, Raza Ur Rehman Rana","doi":"10.1111/jgh.70108","DOIUrl":"https://doi.org/10.1111/jgh.70108","url":null,"abstract":"","PeriodicalId":15877,"journal":{"name":"Journal of Gastroenterology and Hepatology","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145225459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}