Journal of Gastroenterology and Hepatology最新文献

{"title":"Multisystem Comorbidity in Idiopathic Gastroparesis: Clarifying Targeted Clinical Assessment.","authors":"Marie-Claire Seeley, Kate L M Anderson, Emma Tippett, Alan J Hakim, Celine Gallagher","doi":"10.1111/jgh.70820","DOIUrl":"https://doi.org/10.1111/jgh.70820","url":null,"abstract":"","PeriodicalId":15877,"journal":{"name":"Journal of Gastroenterology and Hepatology","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149194641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of AI-Assisted Endoscopy on Secondary Review and Referral Decisions in Gastric Cancer Screening: A Multicenter Real-World Study.","authors":"Sachiyo Onishi, Seiji Adachi, Masahito Shimizu","doi":"10.1111/jgh.70823","DOIUrl":"https://doi.org/10.1111/jgh.70823","url":null,"abstract":"<p><strong>Objectives: </strong>Artificial intelligence (AI)-assisted endoscopy may support gastric cancer screening, but its impact on structured secondary human review remains unclear. We evaluated secondary review modifications and referral decisions before and after AI implementation.</p><p><strong>Methods: </strong>This retrospective multicenter study included 5013 screening esophagogastroduodenoscopy examinations performed before (n = 2021) and after (n = 2992) AI implementation. The primary outcome was secondary review modifications. Secondary outcomes included referral for further diagnostic evaluation. Multivariable logistic regression analyses adjusted for age, sex, Helicobacter pylori eradication status, prior-year endoscopy, and endoscopist experience were performed. Interaction analyses according to endoscopist experience and inverse probability of treatment weighting analyses were conducted. No external reference standard was available to verify secondary-review modifications or referral decisions.</p><p><strong>Results: </strong>Secondary review modifications increased from 1.2% in the pre-AI period to 3.7% in the AI period (p < 0.01). A significant interaction was observed between AI implementation and endoscopist experience (p for interaction < 0.01), with increased modifications primarily among nonexpert endoscopists. Cancer-related modifications remained uncommon but increased after AI implementation (0.6% vs. 0.2%, p = 0.04). Referral rates decreased from 4.9% to 2.8% (p < 0.01), and AI implementation was independently associated with lower odds of referral (adjusted OR = 0.53; 95% confidence interval = 0.36-0.77).</p><p><strong>Conclusions: </strong>AI-assisted endoscopy was associated with lower referral rates; however, secondary review modifications persisted after AI implementation, particularly among nonexpert endoscopists. These findings describe workflow changes and do not establish the clinical validity of the modifications or the appropriateness of referral decisions.</p>","PeriodicalId":15877,"journal":{"name":"Journal of Gastroenterology and Hepatology","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149194670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Risk-Based Prioritization Model for Advanced Colorectal Neoplasia in Thailand: Strengths and Open Questions.","authors":"Yuze Wu, Chengzhi Qiu","doi":"10.1111/jgh.70816","DOIUrl":"https://doi.org/10.1111/jgh.70816","url":null,"abstract":"","PeriodicalId":15877,"journal":{"name":"Journal of Gastroenterology and Hepatology","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149194553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Role of Gut Microbiota in Chronic Constipation and the Therapeutic Potential of Fecal Microbiota Transplantation.","authors":"Xinxin Wang, Lu Wang, Yuedong Liu","doi":"10.1111/jgh.70807","DOIUrl":"https://doi.org/10.1111/jgh.70807","url":null,"abstract":"<p><strong>Objective: </strong>This study investigates the relationship between gut microbiota dysbiosis and chronic constipation (CC) and evaluates the therapeutic efficacy of fecal microbiota transplantation (FMT) in restoring microbial homeostasis and metabolic function.</p><p><strong>Methods: </strong>We retrospectively analyzed existing before-after clinical data from 206 patients with CC who received FMT. No placebo or case-control group was included. Gut microbiota profiles were analyzed before and after FMT using 16S rRNA sequencing. Alpha and beta diversity indices were calculated to assess microbial community evolution. Gas chromatography-mass spectrometry (GC-MS) was employed to quantify short-chain fatty acids (SCFAs). Patients were stratified into butyrate-high and butyrate-low metabolic subtypes using a partitioning around medoids (PAM) algorithm based on pre-transplant butyrate levels. Clinical severity was independently defined using Rome IV criteria, CSBM, BSFS, and PAC-SYM.</p><p><strong>Results: </strong>FMT significantly increased microbial α-diversity and shifted the community structure toward that of healthy donors. Post-transplant, the Bacteroidetes/Firmicutes ratio decreased from 46.8% to 38.9%, with a marked enrichment of beneficial taxa such as Faecalibacterium, Akkermansia, and Bifidobacterium. These shifts correlated with a significant rise in SCFA concentrations, particularly acetic and butyric acids. Butyrate deficiency was characterized by broader SCFA deficiencies and fragmented microbial networks. Multivariable binary logistic regression identified Faecalibacterium, ACE index, and acetic acid as independent predictors of clinically defined constipation severity.</p><p><strong>Conclusion: </strong>FMT was associated with increased microbial diversity, restoration of SCFA-producing taxa, and increased SCFA concentrations in patients with CC. These changes accompanied improvements in CSBM, BSFS, PAC-SYM, and PAC-QOL.</p>","PeriodicalId":15877,"journal":{"name":"Journal of Gastroenterology and Hepatology","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149181741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the Editor Regarding \"BEAT-B Study (Behavior, Aspirations, and Treatment Needs): A Mixed-Methods Study of Patient Values, Preferences, and Barriers to Care Among People Living With Chronic Hepatitis B in South and Southeast Asia\".","authors":"Zhenlin Zhang, Luojie Liu","doi":"10.1111/jgh.70842","DOIUrl":"https://doi.org/10.1111/jgh.70842","url":null,"abstract":"","PeriodicalId":15877,"journal":{"name":"Journal of Gastroenterology and Hepatology","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2026-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149194654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comments on CCT2 Promotes Immune Escape in Colorectal Cancer by Regulating the JAK1-STAT3-PD-L1 Axis.","authors":"Toua Abbasi, Abdullah Abdullah, Asiya Shahzad","doi":"10.1111/jgh.70817","DOIUrl":"https://doi.org/10.1111/jgh.70817","url":null,"abstract":"","PeriodicalId":15877,"journal":{"name":"Journal of Gastroenterology and Hepatology","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2026-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149182537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is Helicobacter pylori Status Responsible for the Altered Pharmacodynamics of Tegoprazan?","authors":"Muhammad Hanzla Shahzad, Muhammad Wajid Siddique","doi":"10.1111/jgh.70814","DOIUrl":"https://doi.org/10.1111/jgh.70814","url":null,"abstract":"","PeriodicalId":15877,"journal":{"name":"Journal of Gastroenterology and Hepatology","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2026-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149181283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the Editor: Strengthening Scientific Rigor in Reviews of Post-Translational Modifications in Pancreatic Cancer: Conceptual and Methodological Considerations.","authors":"Khadija Eman, Fasiha Daud","doi":"10.1111/jgh.70819","DOIUrl":"https://doi.org/10.1111/jgh.70819","url":null,"abstract":"","PeriodicalId":15877,"journal":{"name":"Journal of Gastroenterology and Hepatology","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2026-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149181458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Upadacitinib in East Asia: Translating Trial Results Into Maintenance Care.","authors":"Lee Sheung, Piao Zheng","doi":"10.1111/jgh.70813","DOIUrl":"https://doi.org/10.1111/jgh.70813","url":null,"abstract":"","PeriodicalId":15877,"journal":{"name":"Journal of Gastroenterology and Hepatology","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2026-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149181883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Methodological Considerations in Interpreting Dairy-Free Diet Efficacy in Adult Eosinophilic Oesophagitis.","authors":"Zia Ullah","doi":"10.1111/jgh.70822","DOIUrl":"https://doi.org/10.1111/jgh.70822","url":null,"abstract":"","PeriodicalId":15877,"journal":{"name":"Journal of Gastroenterology and Hepatology","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2026-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149181807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}