Journal of Gastroenterology and Hepatology最新文献

{"title":"A Novel Natural Language Processing Tool Improves Colonoscopy Auditing of Adenoma and Serrated Polyp Detection Rates.","authors":"Melissa Chew, Catherine Yu, Leanne Stojevski, Paul Conilione, Anthony Gust, Mani Suleiman, Will Swansson, Bennett Anderson, Mayur Garg, Diana Lewis","doi":"10.1111/jgh.16933","DOIUrl":"https://doi.org/10.1111/jgh.16933","url":null,"abstract":"<p><strong>Background and study aims: </strong>Determining adenoma detection rate (ADR) and serrated polyp detection rate (SDR) can be challenging as they usually involve manual matching of colonoscopy and histology reports. This study aimed to validate a Natural Language Processing (NLP) code that enables rapid and efficient data extraction to calculate ADR and SDR.</p><p><strong>Design: </strong>A NLP code was developed to automatically extract colonoscopy quality indicators from colonoscopy and histology reports at a tertiary health service. These reports were manually reviewed to verify the concordance of ADR and SDR between the two methods. This process was applied in the initial training phase, repeated following modification of the code, and again with a validation cohort.</p><p><strong>Results: </strong>Included in the training and test phases were 5911 colonoscopies, with 2022 in the validation phase. The NLP code extracted patient names with 99.9% concordance and had a 98.9% accuracy in ADR and SDR in the training phase. Search terms were subsequently modified to take into consideration spelling variations and overlapping terminologies. Using data from the same cohort, accuracy of the NLP improved to 100%, excluding four colonoscopies that had missing histology reports in the test phase. Using a validated cohort, NLP had a 99.9% accuracy in ADR and SDR. The total time taken for auditing using NLP in the validation phase was less than 1 h.</p><p><strong>Conclusions: </strong>An automatic NLP code had an accuracy of almost 100% in determining ADR and SDR in a tertiary colonoscopy service. Wider adoption of NLP enables significant improvements in colonoscopy audits that is accurate and time efficient.</p>","PeriodicalId":15877,"journal":{"name":"Journal of Gastroenterology and Hepatology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143753124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of Endoscopy in Clinical Management of Intraductal Papillary Mucinous Neoplasms.","authors":"Tsuyoshi Hamada, Hiroki Oyama, Naminatsu Takahara, Yousuke Nakai, Mitsuhiro Fujishiro","doi":"10.1111/jgh.16938","DOIUrl":"https://doi.org/10.1111/jgh.16938","url":null,"abstract":"<p><p>Intraductal papillary mucinous neoplasm (IPMN) of the pancreas is a well-recognized precursor of pancreatic carcinoma. Along with cross-sectional abdominal imaging tests, endoscopic examinations remain the cornerstone in the diagnosis of pancreatic cysts, early detection of IPMN-derived carcinomas, and risk stratification of patients with IPMNs for subsequent surveillance strategies. In particular, endoscopic ultrasound (EUS) facilitates the optimal patient management by providing high-resolution morphological information, and the contrast-enhanced harmonic mode may further enhance diagnostic accuracy. EUS-guided fine-needle aspiration for solid mass and/or cyst fluid is considered for pathological and molecular examinations for the diagnosis of pancreatic cysts and malignancy. Emerging evidence suggests the usefulness of through-the-needle biopsy and confocal laser microendoscopy in this setting. In addition to the undoubtful diagnostic utility, recent studies have demonstrated the potential effect of endoscopic interventions (i.e., ablation) on the control of IPMNs. Despite the increasing role of endoscopy in the clinical management of IPMNs, there remains a gap in our understanding of how to utilize endoscopy in the personalized care for patients with IPMNs (e.g., the optimal interval of EUS) and the prevention of deaths due to pancreatic carcinomas developing concomitantly with IPMNs. This review summarizes the current evidence on the role of endoscopy in both the diagnostic and therapeutic landscapes of clinical management of IPMNs and identifies key clinical unmet needs that should be addressed in future research. Combined with emerging technologies (e.g., artificial intelligence and high-throughput molecular profiling), endoscopy would offer more effective and tailored management strategies for patients with IPMNs.</p>","PeriodicalId":15877,"journal":{"name":"Journal of Gastroenterology and Hepatology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143753155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preferred Reporting Items for Microbiotherapy (PRIM) Guidelines Across Medical Disciplines: An International Delphi Consensus.","authors":"Faming Zhang, Michael A Kamm, Xia Wu, Dina Kao, Thomas J Borody, Lea Ann Chen, Xingxiang He, Monika Fischer, Sunny H Wong, Siew C Ng, Bota Cui, Francis K-L Chan, Yongzhan Nie, Ajit Sood, Jingnan Li, Yang Sun, Ishikawa Dai, Qiyi Chen, Muhan Lv, Zulun Zhang, Gianluca Ianiro, Yunsheng Yang, Colleen R Kelly","doi":"10.1111/jgh.16947","DOIUrl":"https://doi.org/10.1111/jgh.16947","url":null,"abstract":"<p><p>Microbiotherapy has opened new avenues for managing dysbiosis-related diseases. However, many studies did not cover all the necessary reporting items for microbiotherapy making the interpretation of results, safety assessment, technology extension, and even the transparency of legitimacy difficult. This project consisted of 2 phases. First, we proposed an initial preferred reporting items for microbiotherapy (PRIM) checklist and applied it to oncology studies from 2011 to 2023 according to Meta-Analyses guideline. Only 39.3% (n = 64) of these studies (n = 163) met all PRIM checklist items. The culture-based microbiotherapy (CMT) studies had higher score than non-culture-based (NMT) ones (p = 0.018). In the second phase, the expert panel consisting of 22 specialists from eight countries across Asia, Australia, Europe, and North America refined and finalized the PRIM guidelines (named as PRIM 2024) through Delphi consensus. The PRIM 2024 guidelines conclude 10 statements and 18 points on diagnosis, delivery route, source, classification, preparation, dosage, state, concomitant treatment, efficacy, and safety. The panel defined less than 80% of all PRIM points (14 points) as low-quality reports. These guidelines are recommended for reporting on microbiotherapy in clinical studies and reports on compassionate use, including but not limited to fecal microbiota transplantation, phage therapy, probiotics, and synbiotics. These consistent and transparent reporting items can help researchers and practitioners better evaluate, compare, implement research findings in microbiotherapy.</p>","PeriodicalId":15877,"journal":{"name":"Journal of Gastroenterology and Hepatology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143719816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to Editor: Addressing Methodological and Interpretative Gaps in the Study on Bowel Preparation and Gut Microbiotad.","authors":"Brijesh Sathian, Hanadi Al Hamad, Javed Iqbal","doi":"10.1111/jgh.16957","DOIUrl":"https://doi.org/10.1111/jgh.16957","url":null,"abstract":"","PeriodicalId":15877,"journal":{"name":"Journal of Gastroenterology and Hepatology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143719814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Characteristics and Long-Term Efficacy of Peroral Endoscopic Myotomy in Pediatric Achalasia.","authors":"Yuto Shimamura, Hiroki Sato, Ryusuke Yagi, Hirofumi Abe, Hironari Shiwaku, Junya Shiota, Chiaki Sato, Kenta Hamada, Masaki Ominami, Yoshitaka Hata, Hisashi Fukuda, Ryo Ogawa, Jun Nakamura, Tetsuya Tatsuta, Yuichiro Ikebuchi, Haruhiro Inoue","doi":"10.1111/jgh.16945","DOIUrl":"https://doi.org/10.1111/jgh.16945","url":null,"abstract":"<p><strong>Background and aims: </strong>Pediatric achalasia and peroral endoscopic myotomy (POEM) are not well investigated. This study aimed to examine the clinical characteristics of pediatric achalasia and evaluate the long-term outcomes of POEM.</p><p><strong>Methods: </strong>We conducted a multicenter study across 14 high-volume centers, comparing the clinical characteristics of children (aged < 18 years) diagnosed with achalasia to those of adults (aged < 65 years). The POEM procedures and outcomes were also compared between the two groups.</p><p><strong>Results: </strong>Of the 3421 patients with achalasia, 50 (1.5%) were children. Compared with adults, children had a shorter period to diagnosis (1.0 vs. 3.4 years; p < 0.001) and were more likely to be severely underweight (body mass index: 17.8 vs. 20.9 kg/m²; p < 0.001). However, children exhibited less esophageal dilation (46.0% vs. 64.1%; p = 0.013) and higher lower esophageal sphincter pressure (37.3 vs. 29.9 mmHg; p = 0.002). Notably, a significant failure to thrive was not observed in the pediatric group. The POEM procedure time was shorter for children compared to adults (58.0 vs. 83.0 min; p < 0.001). Clinical success rates were not significant between the two groups. Over the 5-year follow-up period, children had a lower incidence of reflux esophagitis following POEM compared to adults (11.0% vs. 26.4%; p = 0.013).</p><p><strong>Conclusions: </strong>Pediatric achalasia is rare and typically presents with early-stage manometric and esophagogastric features, along with severe systemic symptoms requiring an early diagnosis. POEM is a durable and effective treatment for pediatric achalasia, offering advantages such as shorter procedural times and a lower incidence of postprocedure reflux compared to adults.</p>","PeriodicalId":15877,"journal":{"name":"Journal of Gastroenterology and Hepatology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143719810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is Telemedicine Enough to Eradicate Hepatitis C Virus by 2030?","authors":"Amina Hassan","doi":"10.1111/jgh.16952","DOIUrl":"https://doi.org/10.1111/jgh.16952","url":null,"abstract":"","PeriodicalId":15877,"journal":{"name":"Journal of Gastroenterology and Hepatology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143719812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Benefits of TIPS for Patients With Large Ascites Preceding Recurrent or Refractory ascites: A Multicenter Cohort Study.","authors":"Yifu Xia, Jun Tie, Guangchuan Wang, Hao Wu, Yuzheng Zhuge, Xulong Yuan, Guangjun Huang, Zhen Li, Xu Liu, Anbang Chen, Linhao Zhang, Zihao Cai, Chengwei Tang, Chunqing Zhang","doi":"10.1111/jgh.16948","DOIUrl":"https://doi.org/10.1111/jgh.16948","url":null,"abstract":"<p><strong>Background and aim: </strong>Patients with recurrent or refractory ascites can benefit from transjugular intrahepatic portosystemic shunt (TIPS). However, the value of TIPS for patients with large ascites remains unclear.</p><p><strong>Methods: </strong>This retrospective multicenter study included patients who underwent TIPS or medicine plus large-volume paracentesis (medicine + LVP) for ascites between January 2014 and December 2022 at five centers. The primary endpoint was recurrence or worsening of ascites. The secondary endpoints were liver-related death, all-cause hemorrhage, overt hepatic encephalopathy (OHE), and shunt dysfunction.</p><p><strong>Results: </strong>Overall, 724 patients were evaluated, including 373 patients with large ascites preceding recurrent or refractory ascites received TIPS (the LA-TIPS group), 282 patients with recurrent and refractory ascites received TIPS (the RA-TIPS group), and 69 patients with large ascites preceding recurrent or refractory ascites received medicine + LVP (the LA-M group). Patients in the LA-TIPS group had significantly lower incidences of recurrence or worsening of ascites (37.4% vs. 45.3%, p < 0.001), liver-related death (44.8% vs. 62.0%, p < 0.001), and OHE (47.3% vs. 60.3%, p < 0.001) than those in the RA-TIPS group. Meanwhile, patients in the LA-TIPS group had significantly lower incidences of recurrence or worsening of ascites (37.4% vs. 44.6%, p = 0.006) and hemorrhage (38.3% vs. 47.2%, p = 0.042), but a higher incidence of OHE (34.2% vs. 4.5%, p < 0.001) than those in the LA-M group.</p><p><strong>Conclusions: </strong>In terms of controlling ascites, the benefit of TIPS was greater in patients with large ascites preceding recurrent or refractory ascites, suggesting that TIPS might be considered in patients with large ascites before they progress to recurrent or refractory stages.</p>","PeriodicalId":15877,"journal":{"name":"Journal of Gastroenterology and Hepatology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143710152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Role of BMP2/4 in Intestinal Ischemia-Reperfusion Injury: Bridging Smad1/5 and Notch Pathways via Smad6.","authors":"Binyu Luo, Qin Zhang, Long Qin, Xiangxin Kong, Ke Song, Zhenghang Yu, Yixing Ren","doi":"10.1111/jgh.16944","DOIUrl":"https://doi.org/10.1111/jgh.16944","url":null,"abstract":"<p><strong>Background and aim: </strong>Intestinal ischemia-reperfusion (I/R) injury is a significant clinical problem linked to conditions like acute mesenteric ischemia and intestinal obstruction. This study explores the mechanisms of bone morphogenetic proteins (BMPs)-Smads and Notch pathways in I/R injury.</p><p><strong>Methods: </strong>The study employed both in vitro experiments and animal models to analyze the interactions between BMP2/4, the Smad1/5 pathway, and the Notch signaling pathway. Various assays, including western blotting, immunohistochemistry, and RNA sequencing, were utilized to measure molecular and cellular changes. The effects of BMP and Notch pathway inhibitors were also assessed. Specifically, barrier function, cell damage, and inflammatory responses were investigated.</p><p><strong>Results: </strong>Elevated levels of BMP2/4 were observed following intestinal I/R, leading to the activation of the Smad1/5 pathway, which contributed to mucosal barrier damage and increased inflammatory responses. Blocking BMPs or intervening in Notch intracellular domain (NICD), hairy and enhancer of split-1 (HES-1), and Smad6 produced significant regulatory effects on cell damage, inflammatory responses, and barrier function integrity in both in vivo and in vitro models.</p><p><strong>Conclusions: </strong>The findings indicate that BMP2/4 exacerbate intestinal I/R injury through the Smad1/5 pathway, promoting mucosal barrier breakdown and inflammation. The Notch pathway appears to counteract these effects, offering potential therapeutic targets. Further research may focus on developing strategies to modulate these pathways to improve clinical outcomes in intestinal I/R injury.</p>","PeriodicalId":15877,"journal":{"name":"Journal of Gastroenterology and Hepatology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143710160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinicopathological Features of Esophageal Squamous Cell Carcinomas in Patients With No History of Tobacco Smoking or Alcohol Consumption.","authors":"Yoko Tateishi, Takehide Fukuchi, Kingo Hirasawa, Shin Maeda, Koji Okudela, Yukihiro Nakanishi, Mika Tsunomiya, Miwako Arima, Tetsuo Nemoto, Tsuneo Oyama, Yoshiaki Inayama","doi":"10.1111/jgh.16946","DOIUrl":"https://doi.org/10.1111/jgh.16946","url":null,"abstract":"<p><strong>Background and aim: </strong>Esophageal squamous cell carcinoma (ESCC) in patients with no history of tobacco smoking or alcohol consumption accounts for approximately 5% of all ESCCs. This study aimed to clarify the clinicopathological features of superficial ESCCs in patients with no history of tobacco smoking or alcohol consumption.</p><p><strong>Methods: </strong>Clinical data and pathological features of 108 superficial ESCCs in endoscopic submucosal dissection (ESD) specimens obtained from 102 patients with no history of tobacco smoking or alcohol consumption (NTNA group) were reviewed. For comparison, the clinicopathological features of 767 superficial ESCCs in ESD specimens from 544 patients with history of tobacco smoking and alcohol consumption (TA group) were also reviewed. Factors analyzed included age, sex, synchronous/metachronous cancer, gastroesophageal reflux disease (GERD), tumor size, tumor site, macroscopic type, Lugol-voiding lesion (LVL) grade, invasion depth, and lymphovascular invasion. LVLs were graded as A (no lesions), B (1-9 lesions), and C (> 9 lesions).</p><p><strong>Results: </strong>The univariate analysis revealed that female predominance (p < 0.01), absence of synchronous/metachronous cancer (p < 0.01), grade A LVLs (p < 0.01), presence of GERD (p < 0.01), tumor location in the middle thoracic esophagus (p < 0.05), tumor location at the posterior wall (p < 0.05), and 0-IIa macroscopic type (p < 0.01) were significantly more frequently observed in NTNA group than in TA group. Multivariate analysis identified female predominance (OR 68.2, p < 0.001), LVL grade A (OR 50.6, p < 0.001), and 0-IIa macroscopic type (OR 7.2, p < 0.001) as significant features in the NTNA group.</p><p><strong>Conclusions: </strong>This study demonstrated the unique clinicopathological features of ESCCs in patients with NTNA.</p>","PeriodicalId":15877,"journal":{"name":"Journal of Gastroenterology and Hepatology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143710155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Understanding Role of Nutrition in Inflammatory Bowel Disease: A Comprehensive Review With Incorporation of AGA Update.","authors":"Galvin Dhaliwal, Dushyant Singh Dahiya, Ashvin Singh Dhaliwal, Hassam Ali, Manesh Kumar Gangwani, Fouad Jaber, Saqr Alsakarneh, Islam Mohamed, Umar Hayat, Bhanu Siva Mohan Pinnam, Sahib Singh, Sasha Mangray, Stephen Bickston","doi":"10.1111/jgh.16939","DOIUrl":"https://doi.org/10.1111/jgh.16939","url":null,"abstract":"<p><p>This comprehensive review delves into the evolving landscape of nutrition's role in Inflammatory Bowel Disease (IBD), while incorporating transformative insights from the recently published American Gastroenterology Association (AGA) clinical practice update (CPU) on diet in IBD. Recent years have witnessed a paradigm shift, recognizing diet not only as an influencer in disease development but also as a disease-modifying factor and treatment avenue for IBD. The AGA CPU endorses a balanced Mediterranean-style diet, emphasizing the need for personalized recommendations tailored to individual patient characteristics, including disease course, surgical history, and pharmacotherapy. The implementation of complex nutritional strategies necessitates the involvement of both gastroenterologists and registered dietitians. Guidance for patients and caregivers is available through organizations such as Crohn's and Colitis Canada and Crohn's and Colitis Foundation. While animal models offer valuable insights, the review underscores their limitations in replicating the complexity of IBD biology observed in humans. It advocates for an exploration of nutrigenomics, utilizing molecular tools to analyze how diet-derived bioactive compounds influence gene expression for precision nutrition insights. Practical challenges in dietary intervention studies, including regional variations and complexities in food handling, require attention for enhanced comparability. Limited data exist on combined dietary and medical therapies, but promising outcomes suggest potential synergies. Precision treatments could develop through an understanding of the function of particular food metabolites in influencing inflammation. The objective of this review is to offer a summary of the present comprehension of diet, serving as both a potential factor contributing to and a therapeutic avenue for IBD. Clinical Trial Registration: This study is not a part of a clinical trial.</p>","PeriodicalId":15877,"journal":{"name":"Journal of Gastroenterology and Hepatology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143710166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}