Journal of Gastroenterology and Hepatology最新文献_第2页

Comment on "CAFs-Derived Exosomes Promote Colorectal Cancer Progression Through METTL1-Mediated m7G Modification of SLC1A5 mRNA". 对“cafs衍生外泌体通过mettl1介导的SLC1A5 mRNA的m7G修饰促进结直肠癌进展”的评论。

IF 3.4 3区医学

Journal of Gastroenterology and Hepatology Pub Date : 2026-04-30 DOI: 10.1111/jgh.70396

Hongyu Chen, Chengchen Li

引用次数: 0

Evaluation of Factors Affecting Alpha Fetoprotein Levels in Patients With Hepatocellular Carcinoma in a Large Multicenter Cohort. 在一项大型多中心队列研究中评估肝癌患者甲胎蛋白水平的影响因素。

IF 3.4 3区医学

Journal of Gastroenterology and Hepatology Pub Date : 2026-04-30 DOI: 10.1111/jgh.70386

Nicole Shu Ying Tang, Ethan Kai Jun Tham, Nicholas Syn, Ken Liu, Gang Chen, Beom Kyung Kim, Mark Muthiah, Takumi Kawaguchi, Asahiro Morishita, Sung Won Lee, Karn Wijarnpreecha, Hirokazu Takahashi, Daniel Q Huang

{"title":"Evaluation of Factors Affecting Alpha Fetoprotein Levels in Patients With Hepatocellular Carcinoma in a Large Multicenter Cohort.","authors":"Nicole Shu Ying Tang, Ethan Kai Jun Tham, Nicholas Syn, Ken Liu, Gang Chen, Beom Kyung Kim, Mark Muthiah, Takumi Kawaguchi, Asahiro Morishita, Sung Won Lee, Karn Wijarnpreecha, Hirokazu Takahashi, Daniel Q Huang","doi":"10.1111/jgh.70386","DOIUrl":"https://doi.org/10.1111/jgh.70386","url":null,"abstract":"Background: Alpha-fetoprotein (AFP) is the most widely used biomarker for hepatocellular carcinoma (HCC). Given the wide variation in AFP values, conventional linear regression methods may provide an incomplete understanding of complex predictor relationships. Therefore, we utilized quantile regression to examine the association of clinical factors with AFP distribution.Methods: In this multicenter study, we analyzed retrospective data from an adult HCC cohort, collected across nine tertiary healthcare institutions from 2003 to 2021. Quantile regression, which can model covariate effects at different specified points of the outcome distribution, was used to account for heterogeneity across the AFP value range, assessing the effects of predictors associated with AFP levels at the 0.10, 0.50, and 0.90 quantiles. Logistic regression was performed with AFP < 20 ng/mL and ≥ 20 ng/mL groups.Results: The cohort included 2298 individuals with HCC, with median AFP of 13.70 ng/mL. Multivariable quantile regression determined that factors such as Asian ethnicity, elevated aspartate aminotransferase (AST), alanine aminotransferase (ALT), Barcelona Clinic Liver Cancer (BCLC) stage, hepatitis B (HBV), and hepatitis C (HCV) were associated with higher AFP, while male sex, older age, higher BMI, and elevated creatinine were associated with lower AFP levels. Compared to metabolic dysfunction-associated steatotic liver disease, HBV (β = 0.44 at Q50) and HCV (β = 0.30 at Q10; β = 0.40 at Q50) were associated with higher AFP.Conclusion: There is substantial heterogeneity in how clinical factors influence AFP levels across its distribution. These data may stimulate the development of more granular cut-points for AFP that differ according to disease stage and etiology.","PeriodicalId":15877,"journal":{"name":"Journal of Gastroenterology and Hepatology","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147773534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Burden of Esophageal Cancer in Asia in 2022 and Projections for 2050. 2022年亚洲食管癌负担及2050年预测。

IF 3.4 3区医学

Journal of Gastroenterology and Hepatology Pub Date : 2026-04-29 DOI: 10.1111/jgh.70400

Hang Yi, Boyuan Wen, Xin Zhao, Mingzhong Wan, Kun Wang, Yinyan Gao, Yan Wang, Guochao Zhang, Gefei Zhao, Yuanda Cheng, Yousheng Mao

{"title":"Burden of Esophageal Cancer in Asia in 2022 and Projections for 2050.","authors":"Hang Yi, Boyuan Wen, Xin Zhao, Mingzhong Wan, Kun Wang, Yinyan Gao, Yan Wang, Guochao Zhang, Gefei Zhao, Yuanda Cheng, Yousheng Mao","doi":"10.1111/jgh.70400","DOIUrl":"https://doi.org/10.1111/jgh.70400","url":null,"abstract":"Background and aim: Esophageal cancer (EC) is a major global health issue, with its burden disproportionately affecting Asia. However, a comprehensive analysis using the latest data and robust future projections for the continent is lacking. We aimed to assess the current EC burden in Asia and project its trajectory to 2050.Methods: We extracted 2022 incidence and mortality data for 47 Asian countries from the GLOBOCAN database. Age-standardized rates (ASRs) were calculated. We analyzed long-term trends using joinpoint regression and assessed correlations between ASRs and the Human Development Index (HDI). Projections to 2050 were calculated based on demographic changes, assuming constant current cancer rates.Results: In 2022, Asia shouldered a disproportionate global burden, accounting for approximately 75% of new esophageal cancer cases (382 800) and deaths (329 800). The burden was heavily concentrated in males and individuals aged 50 and over, with stark geographical disparities; countries like Bangladesh and Mongolia recorded some of the world's highest age-standardized rates. A significant negative correlation was observed between disease rates and the Human Development Index (HDI) in females (p < 0.05), but not in males. Driven purely by demographic changes (population growth and aging), the number of new cases is projected to increase by 89% to 729 000 and deaths by 97% to 649 000 by 2050.Conclusions: Asia's immense EC burden is set to nearly double by 2050 due to demographic shifts, which highlights the substantial pressure on healthcare systems. Mitigating this impending crisis requires immediate, evidence-based interventions focusing on risk factor control and stratified screening for high-risk populations.","PeriodicalId":15877,"journal":{"name":"Journal of Gastroenterology and Hepatology","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147773540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comment on "Novel Liquid Biopsy in Gastrointestinal Cancers". “新型液体活检在胃肠道肿瘤中的应用”述评。

IF 3.4 3区医学

Journal of Gastroenterology and Hepatology Pub Date : 2026-04-29 DOI: 10.1111/jgh.70375

Linfan Qi, Hui Cai

引用次数: 0

Comment on "Liver Fat Quantification and Steatosis Grading in Fatty Liver Disease by Magnetic Resonance Imaging: Systematic Review and Meta-Analysis". “磁共振成像在脂肪肝疾病中的肝脂肪量化和脂肪变性分级：系统综述和荟萃分析”评论。

IF 3.4 3区医学

Journal of Gastroenterology and Hepatology Pub Date : 2026-04-28 DOI: 10.1111/jgh.70383

Yuanyuan Jiang, Jing Wang

引用次数: 0

Tocilizumab Mitigates Immune Checkpoint Inhibitor-Induced Colitis and Inhibits Tumor Growth by Targeting the IL-6-JAK2-STAT3 Signaling Pathway. Tocilizumab通过靶向IL-6-JAK2-STAT3信号通路减轻免疫检查点抑制剂诱导的结肠炎并抑制肿瘤生长

IF 3.4 3区医学

Journal of Gastroenterology and Hepatology Pub Date : 2026-04-28 DOI: 10.1111/jgh.70293

Yanxin Chen, Yong Wang, Ying Hu, Lingrong Luo, Wenjuan Yang, Yu Li, Qian Peng

{"title":"Tocilizumab Mitigates Immune Checkpoint Inhibitor-Induced Colitis and Inhibits Tumor Growth by Targeting the IL-6-JAK2-STAT3 Signaling Pathway.","authors":"Yanxin Chen, Yong Wang, Ying Hu, Lingrong Luo, Wenjuan Yang, Yu Li, Qian Peng","doi":"10.1111/jgh.70293","DOIUrl":"https://doi.org/10.1111/jgh.70293","url":null,"abstract":"Intestinal adverse effects induced by immune checkpoint inhibitors (ICIs) during oncology treatment reduce patients' quality of life and limit the clinical application of ICIs. To elucidate the pathogenesis of ICI-associated colitis and explore potential therapeutic strategies, we established a mouse model of PD-1 inhibitor-induced colitis. Utilizing a comprehensive suite of experimental techniques, including RNA sequencing, single-cell RNA sequencing data analysis, hematoxylin-eosin (HE) staining, immunohistochemistry (IHC), enzyme-linked immunosorbent assay (ELISA), Western blot (WB), small-animal in vivo imaging, and tumor cell function assays, we demonstrated that IL-6 is highly upregulated in the colitis mouse model. Moreover, the IL-6-JAK2-STAT3 signaling pathway was significantly enriched, and the expression of proteins involved in this pathway was reduced following the addition of tocilizumab. This led to a decrease in colonic inflammation and a slowing of tumor growth. Therefore, we conclude that tocilizumab may attenuate PD-1 inhibitor-associated colonic inflammation and coinhibit tumor growth by targeting the IL-6-JAK2-STAT3 pathway, providing new insights for clinical treatment.","PeriodicalId":15877,"journal":{"name":"Journal of Gastroenterology and Hepatology","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147773011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Beyond the Protocol: The Vital Role of Patient Guidance in Modern Gastroenterology and Hepatology. 超越协议：病人指导在现代胃肠病学和肝病学中的重要作用。

IF 3.4 3区医学

Journal of Gastroenterology and Hepatology Pub Date : 2026-04-27 DOI: 10.1111/jgh.70402

Han-Mo Chiu

引用次数: 0

Comment on: "Effects of Piperine on Obese and Lean Nonalcoholic Fatty Liver Disease in Mice". 评论：“胡椒碱对小鼠肥胖和瘦非酒精性脂肪肝的影响”。

IF 3.4 3区医学

Journal of Gastroenterology and Hepatology Pub Date : 2026-04-27 DOI: 10.1111/jgh.70406

Bhoomeeka Jayramdass

引用次数: 0

Extensive Esophageal Duplication in New Zealand Adult Male Demonstrated on Endoscopy and Barium Swallow With Valsalva Maneuver. 内窥镜和钡吞入法显示新西兰成年男性广泛的食管重复。

IF 3.4 3区医学

Journal of Gastroenterology and Hepatology Pub Date : 2026-04-27 DOI: 10.1111/jgh.70410

V Murphy, J Graham, B Watson

{"title":"Extensive Esophageal Duplication in New Zealand Adult Male Demonstrated on Endoscopy and Barium Swallow With Valsalva Maneuver.","authors":"V Murphy, J Graham, B Watson","doi":"10.1111/jgh.70410","DOIUrl":"https://doi.org/10.1111/jgh.70410","url":null,"abstract":"This case report details the diagnosis of an extensive tubular esophageal duplication in a New Zealand adult patient. A 48-year-old man presented to a regional hospital with fever and respiratory symptoms; initial noncontrast CT imaging suggested the impression of a fluid-filled structure possibly representing a hiatal hernia. However, subsequent upper gastrointestinal endoscopy (OGD) revealed an unexpected second lumen in the fundus. The mucosa lining this secondary lumen notably appeared similar to small bowel mucosa, suggesting possible esophageal duplication opening distally at the gastroesophageal junction, representing a rare congenital anomaly. This endoscopic observation prompted targeted advanced imaging based on radiology multidisciplinary meeting (MDM) discussion. Barium swallow with dynamic Valsalva maneuver definitively confirmed the diagnosis, demonstrating reflux contrast illumination into an extensive tubular esophageal duplication, supported by cross-sectional imaging. The manuscript is accompanied by two high-quality figures, showing the condition demonstrated by color upper GI endoscopic images and key selected frames from a barium swallow esophagram and computed tomography of the chest, abdomen, and pelvis (CTCAP). This case highlights the essential role of endoscopy in identifying key internal anatomic features which, when combined with dynamic imaging, are vital for diagnosing rare congenital entities in patients presenting with nonspecific adult symptoms.","PeriodicalId":15877,"journal":{"name":"Journal of Gastroenterology and Hepatology","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147772567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Five-Year Survival Prognosis of Early-Onset and Later-Onset Colorectal Cancer by Clinical and Lifestyle Characteristics. 早期和晚期结直肠癌的临床和生活方式特征对5年生存预后的影响。

IF 3.4 3区医学

Journal of Gastroenterology and Hepatology Pub Date : 2026-04-26 DOI: 10.1111/jgh.70401

Tai-Chuan Kuan, Chun-Ying Wu, Chien-Chih Chen, Edward Giovannucci, Jason J Liu

{"title":"Five-Year Survival Prognosis of Early-Onset and Later-Onset Colorectal Cancer by Clinical and Lifestyle Characteristics.","authors":"Tai-Chuan Kuan, Chun-Ying Wu, Chien-Chih Chen, Edward Giovannucci, Jason J Liu","doi":"10.1111/jgh.70401","DOIUrl":"https://doi.org/10.1111/jgh.70401","url":null,"abstract":"Background and aim: Early-onset colorectal cancer (EOCRC) diagnosed at before 50 years of age has been increasing globally. We conducted a nationwide study to compare the associations of clinical and lifestyle characteristics with 5-year survival between EOCRC and later-onset colorectal cancer (LOCRC) patients.Methods: We studied 92 365 colorectal cancer (CRC) patients from the Taiwan Cancer Registry diagnosed between 2002 and 2015, with mortality follow-up until 2020. Clinical factors included tumor and treatment characteristics. Lifestyle factors included body mass index (BMI), cigarette smoking, and alcohol consumption. Poisson regression was used to obtain risk ratios and 95% confidence intervals for 5-year overall and CRC-specific survival.Results: EOCRC patients had more advanced cancer staging, less right-sided colon cancer, and less treatment delay of ≥ 30 days than LOCRC patients. EOCRC also had a higher proportion of females and current alcohol or cigarette users. Female sex and treatment delay of < 30 days were significantly associated with improved 5-year overall survival among LOCRC patients but not EOCRC patients. After adjusting for sex and tumor characteristics, EOCRC patients demonstrated slightly better 5-year CRC-specific survival than LOCRC individuals for all CRC sites combined, right-sided colon, left-sided colon, and rectum. Underweight BMI was associated with significantly worse survival only in LOCRC patients.Conclusions: Our findings of distinct characteristics and prognosis between EOCRC and LOCRC patients contribute to the understanding of CRC by age at diagnosis, which may inform patient surveillance and counseling, as well as promote studies to evaluate age-specific CRC screening and treatment strategies.","PeriodicalId":15877,"journal":{"name":"Journal of Gastroenterology and Hepatology","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2026-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147773050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0