Journal of Gastroenterology and Hepatology最新文献

{"title":"Natural History and Prognosis of Chronic Hepatitis B Patients in the Indeterminate Phase.","authors":"Hao Jiang, Hongsheng Yu, Yinan Huang, Mingkai Li, Bilan Yang, Xiaoli Xi, Yiming Lei, Bin Wu, Yidong Yang","doi":"10.1111/jgh.16849","DOIUrl":"https://doi.org/10.1111/jgh.16849","url":null,"abstract":"<p><strong>Background and aims: </strong>In chronic hepatitis B (CHB), an indeterminate phase exists outside the typical predefined phases. Our study investigates this indeterminate phase's natural history and prognosis, focusing on antiviral treatment outcomes.</p><p><strong>Methods: </strong>We conducted a retrospective cohort study to compare the risk of transitioning to immune active phase between inactive and indeterminate CHB and the incidence of hepatocellular carcinoma (HCC) and cirrhosis between untreated patients with indeterminate CHB (at baseline and throughout follow-up) and those who received treatment, following standard AASLD 2018 guidance.</p><p><strong>Results: </strong>The risk of transitioning to the immune active phase over 3, 5, and 10 years was 6.3%, 8.9%, and 14.2%, respectively, for inactive phase patients (n = 104). For HBeAg-negative indeterminate phase patients (n = 194), the risk was significantly higher at 23.0%, 31.9%, and 38.2%, and for HBeAg-positive indeterminate phase patients (n = 140), it was 40.4%, 52.0%, and 55.0% (p < 0.001). Inverse probability of treatment weighting (IPTW) was utilized to balance the groups of treated and untreated indeterminate patients. Following IPTW adjustment, the Kaplan-Meier curve analysis indicates that the risk of HCC and cirrhosis among untreated patients (n = 294) is higher than that among treated patients (n = 76), (p = 0.015 and 0.007, respectively). In the multivariable analysis, antiviral therapy remained an independent predictor of a reduced risk of HCC (aHR 0.128, 95% CI 0.031-0.522, p = 0.005) and cirrhosis (aHR 0.148, 95% CI 0.044-0.496, p = 0.002).</p><p><strong>Conclusion: </strong>The indeterminate phase patients had a high-risk transition to active phase, and antiviral therapy can reduce the incidence of developing HCC and cirrhosis.</p>","PeriodicalId":15877,"journal":{"name":"Journal of Gastroenterology and Hepatology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142846819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Simple Prediction Model for Clostridioides difficile Infection: A Hospital-Based Administrative Database Study.","authors":"Kenta Watanabe, Tsuyotoshi Tsuji, Hisanori Matsuzawa, Yohei Saruta, Yosuke Shimodaira, Katsunori Iijima","doi":"10.1111/jgh.16851","DOIUrl":"https://doi.org/10.1111/jgh.16851","url":null,"abstract":"<p><strong>Background and aim: </strong>Few prediction scores for Clostridioides difficile infection (CDI), a potentially life-threatening nosocomial diarrhea, combine high accuracy with simplicity. A simple prediction score for routine clinical practice is needed.</p><p><strong>Methods: </strong>We conducted a retrospective cohort study of all inpatients aged ≥ 18 at a secondary care hospital in Japan. The derivation and validation cohorts consisted of patients from January 2016 to December 2020 and January 2021 to September 2022, respectively. Demographic and clinical data were retrieved using electronic medical records and an administrative database. The primary outcome was to derive and validate an accurate, simple prediction score for primary hospital-onset CDI. A derived prediction score by logistic regression analysis was calibrated and validated.</p><p><strong>Results: </strong>CDI developed in 102 of 25 517 and 25 of 6259 patients in the derived and validation cohorts (2.7 cases/10 000 patient-days). The derived model for predicting CDI, including antibiotic use, acid suppressant (proton pump inhibitors or vonoprazan) use, Charlson comorbidity index, and Barthel index, yielded c-statistics of 0.89 and 0.82 in the derivation and validation cohort. The model was well calibrated.</p><p><strong>Conclusions: </strong>This simple prediction score enables early medical intervention and modification of treatment plans to reduce the risk of developing primary hospital-onset CDI.</p>","PeriodicalId":15877,"journal":{"name":"Journal of Gastroenterology and Hepatology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142846834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of Deep Learning-Based Virtual Lugol Chromoendoscopy for Superficial Esophageal Squamous Cell Carcinoma.","authors":"Yosuke Toya, Sho Suzuki, Yusuke Monno, Ryo Arai, Takahiro Dohmen, Makoto Eizuka, Masatoshi Okutomi, Takayuki Matsumoto","doi":"10.1111/jgh.16843","DOIUrl":"https://doi.org/10.1111/jgh.16843","url":null,"abstract":"<p><strong>Background: </strong>Lugol chromoendoscopy has been shown to increase the sensitivity of detection of esophageal squamous cell carcinoma (ESCC). We aimed to develop a deep learning-based virtual lugol chromoendoscopy (V-LCE) method.</p><p><strong>Methods: </strong>We developed still V-LCE images for superficial ESCC using a cycle-consistent generative adversarial network (CycleGAN). Six endoscopists graded the detection and margins of ESCCs using white-light endoscopy (WLE), real lugol chromoendoscopy (R-LCE), and V-LCE on a five-point scale ranging from 1 (poor) to 5 (excellent). We also calculated and compared the color differences between cancerous and non-cancerous areas using WLE, R-LCE, and V-LCE.</p><p><strong>Results: </strong>Scores for the detection and margins were significantly higher with R-LCE than V-LCE (detection, 4.7 vs. 3.8, respectively; p < 0.001; margins, 4.3 vs. 3.0, respectively; p < 0.001). There were nonsignificant trends towards higher scores with V-LCE than WLE (detection, 3.8 vs. 3.3, respectively; p = 0.089; margins, 3.0 vs. 2.7, respectively; p = 0.130). Color differences were significantly greater with V-LCE than WLE (p < 0.001) and with R-LCE than V-LCE (p < 0.001) (39.6 with R-LCE, 29.6 with V-LCE, and 18.3 with WLE).</p><p><strong>Conclusions: </strong>Our V-LCE has a middle performance between R-LCE and WLE in terms of lesion detection, margin, and color difference. It suggests that V-LCE potentially improves the endoscopic diagnosis of superficial ESCC.</p>","PeriodicalId":15877,"journal":{"name":"Journal of Gastroenterology and Hepatology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142837174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Natural History and Predictors of Clinical Outcomes in Autoimmune Liver Diseases: A Multicenter Study.","authors":"Dujinthan Jayabalan, Yi Huang, Luis Calzadilla-Bertot, Leon A Adams, Wendy Cheng, Simon Hazeldine, Briohny W Smith, Gerry C MacQuillan, Michael C Wallace, George Garas, Gary P Jeffrey","doi":"10.1111/jgh.16850","DOIUrl":"https://doi.org/10.1111/jgh.16850","url":null,"abstract":"<p><strong>Background and aim: </strong>Prognosis in autoimmune hepatitis (AIH), primary biliary cholangitis (PBC), and primary sclerosing cholangitis (PSC) has historically been poor. This multicenter retrospective cohort study investigated the natural history and assessed the predictors of outcomes in patients with AIH, PBC, and PSC.</p><p><strong>Methods: </strong>AIH, PBC, and PSC patients were identified from the state-wide Hepascore and Clinical Outcome cohort. Overall death or transplant, liver-related mortality (liver-related death or transplant), and liver-related decompensation were determined using a population-based data linkage system. Baseline Liver Outcome Score (LOS), Hepascore, and MELD were examined for predicting outcomes.</p><p><strong>Results: </strong>Two-hundred thirty-seven AIH patients (24% male, median age 56.6 years [range, 14.3-94.0]), 157 PBC patients (8.3% male, median age 60.5 years [range, 25.6-87.1]), and 167 PSC patients (52.7% male, median age 55.6 years [range, 18.4-88.6]) were enrolled. Five-year transplant-free survival was 88% (95%CI: 81-92%) in AIH, 92% (95%CI: 85-96%) in PBC, and 61% (95%CI: 51-69%) in PSC. PSC had a significantly worse overall death or transplant, liver-related mortality, and liver-related decompensation when compared to AIH and PBC (p < 0.0001). LOS was a significant independent predictor of overall death or transplant, liver-related mortality, and liver-related decompensation among patients with AIH and PBC. LOS was a significant independent predictor of overall death or transplant in patients with PSC, and Hepascore was a significant independent predictor of liver-related mortality and liver-related decompensation.</p><p><strong>Conclusions: </strong>Outcomes for AIH and PBC are excellent but remain poor in PSC. LOS is a predictor of outcomes in autoimmune liver disease.</p>","PeriodicalId":15877,"journal":{"name":"Journal of Gastroenterology and Hepatology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142837111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Risk-Scoring Models to Predict Gastrointestinal Bleeding in Patients With Direct Oral Anticoagulants.","authors":"Ilsoo Kim, Joon Sung Kim, Dae Young Cheung, Byung-Wook Kim, Jong-Uk Hou","doi":"10.1111/jgh.16853","DOIUrl":"https://doi.org/10.1111/jgh.16853","url":null,"abstract":"<p><strong>Background and aim: </strong>The risk of gastrointestinal bleeding (GIB) remains a concern with the use of direct oral anticoagulants (DOAC). We evaluated the efficacy of four risk-scoring models (HAS-BLED, ATRIA, VTE-BLEED, and ORBIT) in predicting GIB according to the concomitant use of antiplatelet therapy in DOAC users.</p><p><strong>Methods: </strong>Patients prescribed DOAC between December 2014 and October 2020 were enrolled in two university-affiliated hospitals. The performance of the four models was compared based on the concomitant use of antiplatelet therapy. The primary outcomes were likelihood ratios and the area under the receiver operating characteristic (AUROC) curve to predict GIB.</p><p><strong>Results: </strong>A total of 4494 patients were included in the study. The AUROC values for the entire cohort were 0.643 (95% CI: 0.601-0.686) for HAS-BLED, 0.693 (95% CI: 0.649-0.737) for ATRIA, 0.708 (95% CI: 0.665-0.750) for VTE-BLEED, and 0.709 (95% CI: 0.667-0.751) for ORBIT. The AUROC for all scoring models increased in patients without antiplatelet therapy compared to the entire cohort and patients with antiplatelet therapy. The specificity and diagnostic accuracy for all scoring models increased in patients without antiplatelet therapy compared to patients with antiplatelet.</p><p><strong>Conclusions: </strong>Our results confirmed that current risk-scoring models for predicting GIB perform better in patients without antiplatelet therapy than in those on concomitant antiplatelet therapy. This suggests that future risk prediction models should consider the concomitant use of antiplatelet therapy for diagnostic accuracy.</p>","PeriodicalId":15877,"journal":{"name":"Journal of Gastroenterology and Hepatology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142837172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gastrointestinal: Successful Management of Refractory Achalasia Complicated by Delayed Diagnosis and Prolonged Sepsis.","authors":"Dauda Bawa, Rajvinder Singh","doi":"10.1111/jgh.16855","DOIUrl":"https://doi.org/10.1111/jgh.16855","url":null,"abstract":"","PeriodicalId":15877,"journal":{"name":"Journal of Gastroenterology and Hepatology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142829104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Postcholecystectomy Gut Microbiome Changes and the Clinical Impact: A Systematic Review With Narrative Synthesis.","authors":"Tiing Leong Ang, Seok Hwee Koo, Daphne Ang, Chin Kimg Tan, Lai Mun Wang, Sunny Hei Wong, Pierce K H Chow","doi":"10.1111/jgh.16846","DOIUrl":"https://doi.org/10.1111/jgh.16846","url":null,"abstract":"<p><strong>Background: </strong>Cholecystectomy (CCE) can affect the enterohepatic circulation of bile acids and result in gut microbiome changes. This systematic review aimed to clarify the effect of CCE on gut microbiome composition and its clinical impact.</p><p><strong>Method: </strong>A systematic search was conducted in PubMed, Web of Science, and Scopus, combining keywords such as \"cholecystectomy\" or \"post-cholecystectomy\" with \"gut microbiome,\" \"stool microbiome,\" or \"gut dysbiosis.\" Data were extracted and synthesized using narrative review. Study quality was assessed using the Newcastle-Ottawa scale.</p><p><strong>Results: </strong>A total of 1373 articles were screened and 14 studies were selected. Significant but inconsistent microbiome changes were reported. Changes were observed in alpha and beta diversity. At phylum level, an increase in Bacteroides and Ascomycota, decrease in Firmicutes, Actinomycetes, and Basidiomycota, and both increase and decrease in Fusobacteria were reported. At genus level, an increase in Prevotella and a decrease in Faecalibacterium were reported. In post-CCE diarrhea, decreased beta diversity, a decreased F/B ratio, an increase in Prevotella, an increase in Phocaeicola vulgatus, and a decrease in Prevotella copri were noted. For post-CCE syndrome, a higher abundance of Proteobacteria and decreased Firmicutes/Bacteroides (F/B) ratio were reported. A decreased relative abundance of Bifidobacterium longum subsp. longum from controls to CCE without colonic neoplasia to CCE with colonic neoplasia, and an increased abundance of Candida glabrata from controls, to CCE without colonic neoplasia and CCE with colonic neoplasia, were reported.</p><p><strong>Conclusion: </strong>Patients who underwent CCE had significant gut dysbiosis. However, current studies could not clarify the detailed gut microbial structural and functional changes associated with CCE.</p>","PeriodicalId":15877,"journal":{"name":"Journal of Gastroenterology and Hepatology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142829105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to \"Menstrual blood-derived mesenchymal stem cells attenuate inflammation and improve the mortality of acute liver failure combining with A2AR agonist in mice\".","authors":"","doi":"10.1111/jgh.16848","DOIUrl":"https://doi.org/10.1111/jgh.16848","url":null,"abstract":"","PeriodicalId":15877,"journal":{"name":"Journal of Gastroenterology and Hepatology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142829103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identifying Risk Factors of Major Adverse Cardiac Events in Patients With Ulcerative Colitis: A Retrospective Japanese Claims Data Analysis.","authors":"Tomohisa Takagi, Linghua Xu, Masato Hoshi, Shoko Arai","doi":"10.1111/jgh.16831","DOIUrl":"https://doi.org/10.1111/jgh.16831","url":null,"abstract":"<p><strong>Background and aim: </strong>We conducted a retrospective study to identify incidence rates and potential risk factors of major adverse cardiac events (MACE) in Japanese patients with ulcerative colitis (UC), as existing data are scarce, inconsistent, and provide limited representation of the real-world situation of MACE in Japan.</p><p><strong>Methods: </strong>We utilized administrative claims data, collected between January 2013 and December 2022, from Medical Data Vision, Japan. Patients (aged ≥ 20 years) diagnosed with UC within ± 1 month of the prescription date during the study period were included in the incident cohort. Exclusions comprised patients diagnosed with UC in the first 365 days or with myocardial infarction, heart failure, stroke, or other ischemic heart diseases within 30 days pre-index. The cumulative incidence rate of MACE was calculated using the Kaplan-Meier method. Multivariate Cox regression models were used to calculate hazard ratios (HRs) for all relevant potential risk factors.</p><p><strong>Results: </strong>Of 11 407 patients in the incident cohort, 91 (0.8%) experienced incident MACE. Over 120 months, the cumulative incidence rate of MACE was 2.86% (95% confidence interval [CI]: 1.89-4.32). Significant HRs (95% CI) were found for age category (≥ 65 years) (4.557 [2.786-7.452]), diabetes (1.709 [1.030-2.835]), and atrial fibrillation (AF) (2.759 [1.188-6.405]) (all p < 0.05). Patients with a history of stroke showed numerically increased risk (1.871 [0.508-6.886]) of MACE.</p><p><strong>Conclusions: </strong>The cumulative incidence rate of MACE was 2.86% over 120 months. Age, comorbidities of diabetes and AF, and history of stroke were the major risk factors for MACE in Japanese UC patients.</p>","PeriodicalId":15877,"journal":{"name":"Journal of Gastroenterology and Hepatology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142813002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Moderated Poster Presentation","authors":"","doi":"10.1111/jgh.16778","DOIUrl":"10.1111/jgh.16778","url":null,"abstract":"&lt;p&gt;&lt;b&gt;MP-01-01&lt;/b&gt;&lt;/p&gt;&lt;p&gt;&lt;b&gt;Bloody stool: diagnosis from colonoscopy findings in Dr. Cipto Mangunkusumo General National Hospital&lt;/b&gt;&lt;/p&gt;&lt;p&gt;&lt;b&gt;Saskia Nursyirwan&lt;/b&gt;&lt;sup&gt;1&lt;/sup&gt; and Izzati Diyanah&lt;sup&gt;2&lt;/sup&gt;&lt;/p&gt;&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;&lt;i&gt;Division of Gastroenterology, Pancreatobiliary, and Digestive Endoscopy, Department of Internal Medicine, Dr. Cipto Mangunkusumo Hospital/Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia;&lt;/i&gt; &lt;sup&gt;2&lt;/sup&gt;&lt;i&gt;Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia&lt;/i&gt;&lt;/p&gt;&lt;p&gt;Moderated Poster 1, November 22, 2024, 12:20 PM - 12:50 PM.&lt;/p&gt;&lt;p&gt;&lt;b&gt;&lt;i&gt;Objectives:&lt;/i&gt;&lt;/b&gt; A colonoscopy is a diagnostic and therapeutic tool widely used to confirm the diagnosis of digestive tract diseases, including GI bleeding. It is beneficial in determining the etiology of a complaint. Bloody stool is one of the complaints frequently encountered in health facilities. This study examines the various colonoscopy findings in patients with bloody stool who underwent gastrointestinal colonoscopy. It is essential to determine the enforcement of the diagnosis and provide appropriate management.&lt;/p&gt;&lt;p&gt;&lt;b&gt;&lt;i&gt;Materials and methods:&lt;/i&gt;&lt;/b&gt; Data were retrospectively collected and analyzed from the medical records of patients who underwent colonoscopy procedures between 2021–2023 at Digestive Endoscopy Center, Dr. Cipto Mangunkusumo General National Hospital.&lt;/p&gt;&lt;p&gt;&lt;b&gt;&lt;i&gt;Results:&lt;/i&gt;&lt;/b&gt; Between 2021 and 2023, data from 1,120 colonoscopy patients at Dr. Cipto Mangunkusumo General National Hospital revealed that 656 (58.6%) were female and 464 (41.4%) were male. Among the 372 patients reporting bloody stool. The most common findings were internal or external hemorrhoids (38.98%), followed by proctitis (18.28%), and other findings that were dominated by tumors or masses (17.5%). Other diagnoses included polyps (12.36%), ileitis (9.7%), colorectal cancer (7.26%), ulcerative colitis (5.64%), and Crohn's disease (5.1%). Diverticulosis and rectal ulcers were each identified in 11 patients (2.96%). On the other hand, 12 patients (3.22%) were identified as normal in their colonoscopy results.&lt;/p&gt;&lt;p&gt;&lt;b&gt;&lt;i&gt;Conclusion:&lt;/i&gt;&lt;/b&gt; This study found that most colonoscopy findings in patients with bloody stool are internal or external hemorrhoids, followed by proctitis and other findings that were dominated by tumors or masses.&lt;/p&gt;&lt;p&gt;&lt;b&gt;MP-01-02&lt;/b&gt;&lt;/p&gt;&lt;p&gt;&lt;b&gt;Effect and safety of sofosbuvir/velpatasvir/voxilaprevir for patients with CHC previously treated with DAAs&lt;/b&gt;&lt;/p&gt;&lt;p&gt;Sangdeok Shin&lt;sup&gt;1&lt;/sup&gt;, Sung Hwan Yoo&lt;sup&gt;2,3&lt;/sup&gt;, Tae Seop Lim&lt;sup&gt;2,4&lt;/sup&gt;, Chang Won Ha&lt;sup&gt;1&lt;/sup&gt;, Byeong Geun Song&lt;sup&gt;1&lt;/sup&gt;, Myung Ji Goh&lt;sup&gt;1&lt;/sup&gt;, Dong Hyun Shin&lt;sup&gt;1&lt;/sup&gt;, Geum-Youn Gwak&lt;sup&gt;1&lt;/sup&gt;, Young Han Paik&lt;sup&gt;1,6&lt;/sup&gt;, Moon Seok Choi&lt;sup&gt;1&lt;/sup&gt;, Hye Won Lee&lt;sup&gt;2,5&lt;/sup&gt; and Wonseok Kang&lt;sup&gt;1,6&lt;/sup&gt;&lt;/p&gt;&lt;p&gt;&lt;sup&gt;1&lt;/sup&gt;&lt;i&gt;Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine;&lt;/i&gt; &lt;sup&gt;2&lt;/sup&gt;&lt;i&gt;Department of Internal ","PeriodicalId":15877,"journal":{"name":"Journal of Gastroenterology and Hepatology","volume":"39 S2","pages":"28-36"},"PeriodicalIF":3.7,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jgh.16778","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142818284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}