Journal of Gastroenterology and Hepatology最新文献

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Long-Term Prognostic Factors for Patients Aged 80 and Older With Superficial Esophageal Squamous Cell Carcinoma Undergoing Endoscopic Submucosal Dissection. 80岁及以上浅表性食管鳞状细胞癌患者行内镜下粘膜剥离的远期预后因素分析。
IF 3.7 3区 医学
Journal of Gastroenterology and Hepatology Pub Date : 2024-12-26 DOI: 10.1111/jgh.16859
Yugo Suzuki, Daisuke Kikuchi, Kenichi Ohashi, Shu Hoteya
{"title":"Long-Term Prognostic Factors for Patients Aged 80 and Older With Superficial Esophageal Squamous Cell Carcinoma Undergoing Endoscopic Submucosal Dissection.","authors":"Yugo Suzuki, Daisuke Kikuchi, Kenichi Ohashi, Shu Hoteya","doi":"10.1111/jgh.16859","DOIUrl":"https://doi.org/10.1111/jgh.16859","url":null,"abstract":"<p><strong>Background and aim: </strong>Endoscopic submucosal dissection (ESD) is an acceptable treatment for superficial esophageal squamous cell carcinoma (ESCC) even in elderly patients. However, studies on the prognostic factors in very elderly patients are limited. Therefore, we aimed to explore the prognostic factors affecting overall survival (OS) in patients aged ≥ 80 with superficial ESCC who underwent ESD.</p><p><strong>Methods: </strong>This study included 155 patients aged ≥ 80 who underwent ESD for superficial ESCC. Clinicopathological findings and long-term outcomes were examined. The prognostic nutritional index (PNI) and geriatric nutritional index (GNRI) were used to assess pre-treatment nutritional status.</p><p><strong>Results: </strong>Twenty-nine patients (18.7%) were aged ≥ 85. Thirty-five (22.6%) and 61 (39.4%) patients had a GNRI < 92 and PNI < 45, respectively. Metastatic relapse was observed in five cases, four (80%) of which resulted in death due to the primary disease. The median OS of all patients was 86 months. Although factors specifically associated with disease-specific survival were not identified, GNRI, PNI, comorbidity, and physical status were associated with OS. In multivariate analysis, age ≥ 85 years (p = 0.03), GNRI (p < 0.01), and PNI (p < 0.01) remained factors associated with OS. Patients aged ≥ 85 with either GNRI ≥ 92 or PNI ≥ 45 had a median OS of 106 months, whereas those aged ≥ 85 with GNRI < 92 had a median OS of 12 months.</p><p><strong>Conclusions: </strong>GNRI and PNI are important indicators for assessing the suitability of ESD in elderly patients aged ≥ 80. These indices can help predict OS and guide clinical decision-making for this patient population.</p>","PeriodicalId":15877,"journal":{"name":"Journal of Gastroenterology and Hepatology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142895194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Asia-Pacific Survey on the Management of Helicobacter pylori Infection. 亚太地区幽门螺杆菌感染管理调查。
IF 3.7 3区 医学
Journal of Gastroenterology and Hepatology Pub Date : 2024-12-26 DOI: 10.1111/jgh.16862
Koji Otani, Dao Viet Hang, Rapat Pittayanon, Henry Liu, Kee Huat Chuah, John Hsiang, Ning Zhang, Akira Higashimori, Yasuhiro Fujiwara
{"title":"Asia-Pacific Survey on the Management of Helicobacter pylori Infection.","authors":"Koji Otani, Dao Viet Hang, Rapat Pittayanon, Henry Liu, Kee Huat Chuah, John Hsiang, Ning Zhang, Akira Higashimori, Yasuhiro Fujiwara","doi":"10.1111/jgh.16862","DOIUrl":"https://doi.org/10.1111/jgh.16862","url":null,"abstract":"<p><strong>Background and aim: </strong>Gastric cancer (GC)-related incidence and mortality rates remain high owing to Helicobacter pylori infection in Asia, and the importance of primary and secondary prevention of GC has been well recognized. We aimed to investigate the extent of overall agreement among clinicians in the Asia-Pacific region regarding the management of H. pylori infection.</p><p><strong>Methods: </strong>The Upper Gastrointestinal (GI) Focus Group of the Asian Pacific Association of Gastroenterology-Emerging Leaders Committee developed an international survey, which was distributed to 98 clinicians in the Asia-Pacific region, compromising an online questionnaire focusing on the management of H. pylori infection.</p><p><strong>Results: </strong>Participants responded from Japan (15, 15.3%), Hong Kong (15, 15.3%), Thailand (33, 33.7%), Vietnam (23, 23.5%), Malaysia (4, 4.1%), Singapore (3, 3.1%), and others (5, 5.1%). The most common first-line eradication regimen was clarithromycin (CAM) triple therapy, including proton pump inhibitor (PPI), amoxicillin (AMPC), and CAM (64.3%) for 14 days (70.4%). The most common second-line eradication regimen was levofloxacin (LVX) triple therapy, including PPI, AMPC, and LVX (22.4%) for 14 days (67.3%). Eradication therapy was deemed necessary for all asymptomatic adults and minors (aged ≤ 17 years) currently infected with H. pylori by 81.6% and 64.3% of respondents, respectively, with 82.7% considering upper GI endoscopy for GC screening useful in the secondary prevention of GC.</p><p><strong>Conclusion: </strong>There appears to be a growing consensus among clinicians, acknowledging the necessity of eradication therapy. We anticipate that this study will establish a new benchmark in preventive medicine aimed at eradicating GC in the Asia-Pacific region.</p>","PeriodicalId":15877,"journal":{"name":"Journal of Gastroenterology and Hepatology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142895152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exploring the Association Between Food Insecurity, Bowel Health, and All-Cause Mortality in the United States: Insights from NHANES 2005-2010. 探索美国食品不安全、肠道健康和全因死亡率之间的关系:来自NHANES 2005-2010的见解。
IF 3.7 3区 医学
Journal of Gastroenterology and Hepatology Pub Date : 2024-12-26 DOI: 10.1111/jgh.16861
Yunlong Li, Yang Chen, Ziqing Yu, Xiaoyin Bai, Gechong Ruan, Yinghao Sun, Wei Han, Hong Yang, Xiaoqing Li
{"title":"Exploring the Association Between Food Insecurity, Bowel Health, and All-Cause Mortality in the United States: Insights from NHANES 2005-2010.","authors":"Yunlong Li, Yang Chen, Ziqing Yu, Xiaoyin Bai, Gechong Ruan, Yinghao Sun, Wei Han, Hong Yang, Xiaoqing Li","doi":"10.1111/jgh.16861","DOIUrl":"https://doi.org/10.1111/jgh.16861","url":null,"abstract":"<p><strong>Background and aim: </strong>Functional gastrointestinal disorders such as chronic constipation (CC) and chronic diarrhea (CD) impose a significant burden on global healthcare resources. Food insecurity, a crucial social determinant of health, remains unclearly associated with CC and CD. We aim to explore the association between food insecurity and CC and CD, and its impact on all-cause mortality among participants with abnormal bowel health.</p><p><strong>Methods: </strong>We used data from National Health and Nutrition Survey 2005-2010. We assessed food insecurity using the Household Food Security Survey Module, and bowel health, including CD and CC, was evaluated using fecal characteristics and bowel movement frequency from the Bowel Health Questionnaire. Finally, 13 199 participants were included.</p><p><strong>Results: </strong>A total of 15.26% (2014) participants experienced food insecurity. Multivariate analysis revealed that food insecurity was associated with a higher proportion of CD (odds ratio [OR]: 1.24, 95% confidence interval [CI]: 1.02-1.52, p = 0.03), especially in women. CC did not exhibit a significant association with food insecurity (OR: 1.10, CI: 0.86-1.40, p = 0.41). Furthermore, food insecurity was significantly linked to higher all-cause mortality in patients with CD (OR: 1.59, CI: 1.01-2.50, p = 0.046) and CC (OR: 2.01, CI: 1.20-3.46, p = 0.01).</p><p><strong>Conclusions: </strong>Assessing food insecurity's impact on bowel health is crucial for policy formulation and risk identification. Research should explore links between food insecurity and CD or CC severity, treatment, and psychosocial aspects to improve patient quality of life.</p>","PeriodicalId":15877,"journal":{"name":"Journal of Gastroenterology and Hepatology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142895174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Efficacy of a Novel Adjustable Snare Technique Versus the Conventional Technique for Converting the Orobiliary Catheter to a Nasobiliary Catheter. 一种新型可调节陷阱技术与传统技术在将口胆管转换为鼻胆管的疗效比较。
IF 3.7 3区 医学
Journal of Gastroenterology and Hepatology Pub Date : 2024-12-26 DOI: 10.1111/jgh.16860
Xinglin Li, Yumei Ning, Yue Zhu, Wei Li, Pengcheng Yang, Jing Wang, Xiaojun He, Qiu Zhao, Lingling Duan, Xiaodan Zhang
{"title":"Efficacy of a Novel Adjustable Snare Technique Versus the Conventional Technique for Converting the Orobiliary Catheter to a Nasobiliary Catheter.","authors":"Xinglin Li, Yumei Ning, Yue Zhu, Wei Li, Pengcheng Yang, Jing Wang, Xiaojun He, Qiu Zhao, Lingling Duan, Xiaodan Zhang","doi":"10.1111/jgh.16860","DOIUrl":"https://doi.org/10.1111/jgh.16860","url":null,"abstract":"<p><strong>Background and object: </strong>It is a challenging step to guide a nasobiliary catheter from the mouth to the nasal cavity in endoscopic nasobiliary drainage (ENBD), and new methods are always being explored to improve the procedure. We have developed a novel device which is composed of a dedicated adjustable snare and a tongue depressor-like handle, for completing oral-nasal conversion of the ENBD tube. In this study, we aim to assess the utility of our new technique in repositioning the ENBD catheter by comparing it with conventional guidewire technique.</p><p><strong>Method: </strong>The patients who underwent ENBD at Zhongnan Hospital of Wuhan University were enrolled to the study. They were randomly divided into the new and conventional technique groups. The primary outcome was the first-time success rate of operation. The secondary outcome included the procedure time, the comfortable degree, and adverse event rates.</p><p><strong>Results: </strong>Compared with using the conventional technique, the first-time success rate of operation using the novel adjustable snare technique to replace the ENBD catheter from the mouth to the nostril was significantly improved (76.19% vs. 51.43%, p < 0.001). The procedure time was significantly shorter using the new device (78.96 s vs. 102.4 s, p < 0.001). In addition, the discomfort scores of patients in the new technique group were lower than those in the conventional group (p < 0.001).</p><p><strong>Conclusion: </strong>Our novel adjustable snare technique improved the first-time success rate of the nasobiliary catheter repositioning, shortened the procedure time, and alleviated the patient's discomfort.</p><p><strong>Trial registration: </strong>Chinese Clinical Trial Registry number: ChiCTR2400085838.</p>","PeriodicalId":15877,"journal":{"name":"Journal of Gastroenterology and Hepatology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142895170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Editorial: Learning Curve for ESD and Other Advanced Endoscopy Procedures. 编辑:ESD和其他高级内窥镜检查的学习曲线。
IF 3.7 3区 医学
Journal of Gastroenterology and Hepatology Pub Date : 2024-12-26 DOI: 10.1111/jgh.16864
Tiing Leong Ang, Osamu Dohi, Han-Mo Chiu
{"title":"Editorial: Learning Curve for ESD and Other Advanced Endoscopy Procedures.","authors":"Tiing Leong Ang, Osamu Dohi, Han-Mo Chiu","doi":"10.1111/jgh.16864","DOIUrl":"https://doi.org/10.1111/jgh.16864","url":null,"abstract":"","PeriodicalId":15877,"journal":{"name":"Journal of Gastroenterology and Hepatology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142895157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gastrointestinal: Esophageal Achalasia With Unusual Endoscopic Findings. 胃肠道:食管贲门失弛缓症的内镜异常表现。
IF 3.7 3区 医学
Journal of Gastroenterology and Hepatology Pub Date : 2024-12-18 DOI: 10.1111/jgh.16852
Kazuya Sumi, Haruhiro Inoue
{"title":"Gastrointestinal: Esophageal Achalasia With Unusual Endoscopic Findings.","authors":"Kazuya Sumi, Haruhiro Inoue","doi":"10.1111/jgh.16852","DOIUrl":"https://doi.org/10.1111/jgh.16852","url":null,"abstract":"","PeriodicalId":15877,"journal":{"name":"Journal of Gastroenterology and Hepatology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142854322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical Significance of Lymphatic Involvement in Intramucosal (pT1a) Gastric Cancer Resected by Endoscopic Submucosal Dissection. 内镜下粘膜下剥离术切除粘膜内淋巴结累及胃癌的临床意义。
IF 3.7 3区 医学
Journal of Gastroenterology and Hepatology Pub Date : 2024-12-18 DOI: 10.1111/jgh.16854
Katsunori Matsueda, Yoshiyasu Kono, Koji Miyahara, Masahiro Nakagawa, Hirokazu Mouri, Kazuhiro Matsueda, Kenta Hamada, Masaya Iwamuro, Seiji Kawano, Yoshiro Kawahara, Takehiro Tanaka, Motoyuki Otsuka
{"title":"Clinical Significance of Lymphatic Involvement in Intramucosal (pT1a) Gastric Cancer Resected by Endoscopic Submucosal Dissection.","authors":"Katsunori Matsueda, Yoshiyasu Kono, Koji Miyahara, Masahiro Nakagawa, Hirokazu Mouri, Kazuhiro Matsueda, Kenta Hamada, Masaya Iwamuro, Seiji Kawano, Yoshiro Kawahara, Takehiro Tanaka, Motoyuki Otsuka","doi":"10.1111/jgh.16854","DOIUrl":"https://doi.org/10.1111/jgh.16854","url":null,"abstract":"<p><strong>Background and aim: </strong>Lymphatic involvement is sometimes detected during routine examination of intramucosal (pT1a) gastric cancer resected endoscopically. However, its clinical significance and association with the risk of metastasis remain unknown.</p><p><strong>Methods: </strong>This was a retrospective cohort study of 6797 consecutive patients with pT1a gastric cancers treated by endoscopic submucosal dissection (ESD) at three institutions in Japan from January 2005 to August 2023. Patients with 49 uncommon-type gastric cancer types were excluded. The risk of metastasis for pT1a cancers with lymphatic involvement was quantified by comparing lymph node metastasis and/or metastatic recurrence in patient groups who underwent additional surgery post-ESD or did not undergo surgery but were followed up for > 3 years.</p><p><strong>Results: </strong>Among the 6748 pT1a cancers treated by ESD, 41 lesions (0.6%) had histologically confirmed lymphatic involvement. Among the 41 patients, 1 was excluded from the analysis of metastasis risk because the follow-up period after ESD without additional surgery was ≤ 3 years. Metastasis was identified in 1 of 40 patients analyzed (2.5%; 95% confidence interval [CI] 0.4%-12.9%), and was not detected in any of the 25 patients with pure differentiated-type lesions (0.0%; 95% CI 0.0%-13.7%).</p><p><strong>Conclusions: </strong>The low prevalence of metastasis after ESD for pT1a gastric cancer with lymphatic involvement, particularly in patients with pure differentiated-type lesions, suggests a low risk of metastatic recurrence.</p>","PeriodicalId":15877,"journal":{"name":"Journal of Gastroenterology and Hepatology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142846818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Natural History and Prognosis of Chronic Hepatitis B Patients in the Indeterminate Phase. 不确定期慢性乙型肝炎患者的自然史和预后。
IF 3.7 3区 医学
Journal of Gastroenterology and Hepatology Pub Date : 2024-12-18 DOI: 10.1111/jgh.16849
Hao Jiang, Hongsheng Yu, Yinan Huang, Mingkai Li, Bilan Yang, Xiaoli Xi, Yiming Lei, Bin Wu, Yidong Yang
{"title":"Natural History and Prognosis of Chronic Hepatitis B Patients in the Indeterminate Phase.","authors":"Hao Jiang, Hongsheng Yu, Yinan Huang, Mingkai Li, Bilan Yang, Xiaoli Xi, Yiming Lei, Bin Wu, Yidong Yang","doi":"10.1111/jgh.16849","DOIUrl":"https://doi.org/10.1111/jgh.16849","url":null,"abstract":"<p><strong>Background and aims: </strong>In chronic hepatitis B (CHB), an indeterminate phase exists outside the typical predefined phases. Our study investigates this indeterminate phase's natural history and prognosis, focusing on antiviral treatment outcomes.</p><p><strong>Methods: </strong>We conducted a retrospective cohort study to compare the risk of transitioning to immune active phase between inactive and indeterminate CHB and the incidence of hepatocellular carcinoma (HCC) and cirrhosis between untreated patients with indeterminate CHB (at baseline and throughout follow-up) and those who received treatment, following standard AASLD 2018 guidance.</p><p><strong>Results: </strong>The risk of transitioning to the immune active phase over 3, 5, and 10 years was 6.3%, 8.9%, and 14.2%, respectively, for inactive phase patients (n = 104). For HBeAg-negative indeterminate phase patients (n = 194), the risk was significantly higher at 23.0%, 31.9%, and 38.2%, and for HBeAg-positive indeterminate phase patients (n = 140), it was 40.4%, 52.0%, and 55.0% (p < 0.001). Inverse probability of treatment weighting (IPTW) was utilized to balance the groups of treated and untreated indeterminate patients. Following IPTW adjustment, the Kaplan-Meier curve analysis indicates that the risk of HCC and cirrhosis among untreated patients (n = 294) is higher than that among treated patients (n = 76), (p = 0.015 and 0.007, respectively). In the multivariable analysis, antiviral therapy remained an independent predictor of a reduced risk of HCC (aHR 0.128, 95% CI 0.031-0.522, p = 0.005) and cirrhosis (aHR 0.148, 95% CI 0.044-0.496, p = 0.002).</p><p><strong>Conclusion: </strong>The indeterminate phase patients had a high-risk transition to active phase, and antiviral therapy can reduce the incidence of developing HCC and cirrhosis.</p>","PeriodicalId":15877,"journal":{"name":"Journal of Gastroenterology and Hepatology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142846819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Simple Prediction Model for Clostridioides difficile Infection: A Hospital-Based Administrative Database Study. 艰难梭菌感染的简单预测模型:基于医院管理数据库的研究。
IF 3.7 3区 医学
Journal of Gastroenterology and Hepatology Pub Date : 2024-12-18 DOI: 10.1111/jgh.16851
Kenta Watanabe, Tsuyotoshi Tsuji, Hisanori Matsuzawa, Yohei Saruta, Yosuke Shimodaira, Katsunori Iijima
{"title":"A Simple Prediction Model for Clostridioides difficile Infection: A Hospital-Based Administrative Database Study.","authors":"Kenta Watanabe, Tsuyotoshi Tsuji, Hisanori Matsuzawa, Yohei Saruta, Yosuke Shimodaira, Katsunori Iijima","doi":"10.1111/jgh.16851","DOIUrl":"https://doi.org/10.1111/jgh.16851","url":null,"abstract":"<p><strong>Background and aim: </strong>Few prediction scores for Clostridioides difficile infection (CDI), a potentially life-threatening nosocomial diarrhea, combine high accuracy with simplicity. A simple prediction score for routine clinical practice is needed.</p><p><strong>Methods: </strong>We conducted a retrospective cohort study of all inpatients aged ≥ 18 at a secondary care hospital in Japan. The derivation and validation cohorts consisted of patients from January 2016 to December 2020 and January 2021 to September 2022, respectively. Demographic and clinical data were retrieved using electronic medical records and an administrative database. The primary outcome was to derive and validate an accurate, simple prediction score for primary hospital-onset CDI. A derived prediction score by logistic regression analysis was calibrated and validated.</p><p><strong>Results: </strong>CDI developed in 102 of 25 517 and 25 of 6259 patients in the derived and validation cohorts (2.7 cases/10 000 patient-days). The derived model for predicting CDI, including antibiotic use, acid suppressant (proton pump inhibitors or vonoprazan) use, Charlson comorbidity index, and Barthel index, yielded c-statistics of 0.89 and 0.82 in the derivation and validation cohort. The model was well calibrated.</p><p><strong>Conclusions: </strong>This simple prediction score enables early medical intervention and modification of treatment plans to reduce the risk of developing primary hospital-onset CDI.</p>","PeriodicalId":15877,"journal":{"name":"Journal of Gastroenterology and Hepatology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142846834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Development of Deep Learning-Based Virtual Lugol Chromoendoscopy for Superficial Esophageal Squamous Cell Carcinoma. 基于深度学习的虚拟Lugol色内镜在浅表食管鳞状细胞癌中的应用。
IF 3.7 3区 医学
Journal of Gastroenterology and Hepatology Pub Date : 2024-12-17 DOI: 10.1111/jgh.16843
Yosuke Toya, Sho Suzuki, Yusuke Monno, Ryo Arai, Takahiro Dohmen, Makoto Eizuka, Masatoshi Okutomi, Takayuki Matsumoto
{"title":"Development of Deep Learning-Based Virtual Lugol Chromoendoscopy for Superficial Esophageal Squamous Cell Carcinoma.","authors":"Yosuke Toya, Sho Suzuki, Yusuke Monno, Ryo Arai, Takahiro Dohmen, Makoto Eizuka, Masatoshi Okutomi, Takayuki Matsumoto","doi":"10.1111/jgh.16843","DOIUrl":"https://doi.org/10.1111/jgh.16843","url":null,"abstract":"<p><strong>Background: </strong>Lugol chromoendoscopy has been shown to increase the sensitivity of detection of esophageal squamous cell carcinoma (ESCC). We aimed to develop a deep learning-based virtual lugol chromoendoscopy (V-LCE) method.</p><p><strong>Methods: </strong>We developed still V-LCE images for superficial ESCC using a cycle-consistent generative adversarial network (CycleGAN). Six endoscopists graded the detection and margins of ESCCs using white-light endoscopy (WLE), real lugol chromoendoscopy (R-LCE), and V-LCE on a five-point scale ranging from 1 (poor) to 5 (excellent). We also calculated and compared the color differences between cancerous and non-cancerous areas using WLE, R-LCE, and V-LCE.</p><p><strong>Results: </strong>Scores for the detection and margins were significantly higher with R-LCE than V-LCE (detection, 4.7 vs. 3.8, respectively; p < 0.001; margins, 4.3 vs. 3.0, respectively; p < 0.001). There were nonsignificant trends towards higher scores with V-LCE than WLE (detection, 3.8 vs. 3.3, respectively; p = 0.089; margins, 3.0 vs. 2.7, respectively; p = 0.130). Color differences were significantly greater with V-LCE than WLE (p < 0.001) and with R-LCE than V-LCE (p < 0.001) (39.6 with R-LCE, 29.6 with V-LCE, and 18.3 with WLE).</p><p><strong>Conclusions: </strong>Our V-LCE has a middle performance between R-LCE and WLE in terms of lesion detection, margin, and color difference. It suggests that V-LCE potentially improves the endoscopic diagnosis of superficial ESCC.</p>","PeriodicalId":15877,"journal":{"name":"Journal of Gastroenterology and Hepatology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142837174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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