Journal of Gastroenterology and Hepatology最新文献

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CCL25 contributes to the pathogenesis of D-Gal/LPS-induced acute liver failure. CCL25是D-Gal/LPS诱导的急性肝衰竭的发病机制之一。
IF 3.7 3区 医学
Journal of Gastroenterology and Hepatology Pub Date : 2024-09-04 DOI: 10.1111/jgh.16732
Fei Sun, Jingwei Wang, Xiangfen Ji, Zhenli Wang, Shuai Gao, Kai Wang
{"title":"CCL25 contributes to the pathogenesis of D-Gal/LPS-induced acute liver failure.","authors":"Fei Sun, Jingwei Wang, Xiangfen Ji, Zhenli Wang, Shuai Gao, Kai Wang","doi":"10.1111/jgh.16732","DOIUrl":"https://doi.org/10.1111/jgh.16732","url":null,"abstract":"<p><strong>Background and aim: </strong>Acute liver failure (ALF) is a fatal clinical syndrome of severe hepatic dysfunction. Chemokines promote liver diseases by recruiting and activating immune cells. We aimed to investigate the role of C-C chemokine ligand 25 (CCL25) in ALF.</p><p><strong>Methods: </strong>An ALF mouse model induced by D-galactosamine/lipopolysaccharide was evaluated through liver hematoxylin and eosin staining and serum transaminase and cytokine measurement. CCL25 expression in serum was analyzed by ELISA and in liver by immunohistochemical staining and western blot. C-C chemokine receptor 9 (CCR9)-expressing cells in the liver were identified by immunofluorescence staining. The effects of anti-CCL25 on ALF were evaluated in vivo. Cytokine expression and migration of CCL25-stimulated RAW264.7 macrophages were studied. We also investigated the role of anti-CCL25 and BMS-345541, an NF-κB signaling inhibitor, in vitro. NF-κB activation was assessed via western blot, and p65 nuclear translocation was detected using cellular immunofluorescence.</p><p><strong>Results: </strong>ALF mice showed severe histological damage and high serum levels of aminotransferase and inflammatory cytokines. Elevated CCL25 and NF-κB activation was observed in vivo. CCR9 was expressed on macrophages in ALF mouse liver. ALF was suppressed after anti-CCL25 treatment, with significant NF-κB inhibition. In vitro, CCL25 induced strong migration and cytokine release in RAW264.7 macrophages, which were eliminated by anti-CCL25 and BMS-345541. Furthermore, the NF-κB activation and p65 nuclear translocation induced by CCL25 were also inhibited by anti-CCL25 and BMS-345541.</p><p><strong>Conclusion: </strong>CCL25 contributes to ALF development by inducing macrophage-mediated inflammation via activation of the NF-κB signaling.</p>","PeriodicalId":15877,"journal":{"name":"Journal of Gastroenterology and Hepatology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142132947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Development of irreversible pancreatic ductal change triggered by pancreatic duct stenting in chronic pancreatitis. 慢性胰腺炎患者胰管支架植入引发的不可逆胰管病变
IF 3.7 3区 医学
Journal of Gastroenterology and Hepatology Pub Date : 2024-09-03 DOI: 10.1111/jgh.16733
Kensuke Takuma, Naoki Okano, Yusuke Kimura, Kensuke Hoshi, Yoichiro Sato, Wataru Ujita, Shuntaro Iwata, Hiroki Nakagawa, Koji Watanabe, Yuto Yamada, Susumu Iwasaki, Yoshinori Igarashi, Takahisa Matsuda
{"title":"Development of irreversible pancreatic ductal change triggered by pancreatic duct stenting in chronic pancreatitis.","authors":"Kensuke Takuma, Naoki Okano, Yusuke Kimura, Kensuke Hoshi, Yoichiro Sato, Wataru Ujita, Shuntaro Iwata, Hiroki Nakagawa, Koji Watanabe, Yuto Yamada, Susumu Iwasaki, Yoshinori Igarashi, Takahisa Matsuda","doi":"10.1111/jgh.16733","DOIUrl":"https://doi.org/10.1111/jgh.16733","url":null,"abstract":"<p><strong>Background and aim: </strong>Stent-induced ductal change is a complication of endoscopic pancreatic stent placement for chronic pancreatitis, potentially leading to irreversible changes that may contribute to pancreatic dysfunction. This study aimed to examine the long-term outcomes of stent-induced ductal change and evaluate factors that correlate with the development of irreversible ductal changes.</p><p><strong>Methods: </strong>Between January 2008 and December 2022, 52/223 patients with chronic pancreatitis in whom an S-type plastic stent was successfully placed from the main papilla for duct stricture were detected with stent-induced ductal change on pancreatography at stent removal. We retrospectively investigated the clinical features of patients whose main pancreatic duct was reassessed by endoscopic pancreatography after >1 month without stent and whose residual stent-induced ductal change was irreversible.</p><p><strong>Results: </strong>The patients with chronic pancreatitis with stent-induced ductal change (n = 28) (elevated change, 15; stricture change, 13) were evaluated using follow-up pancreatography. Eleven patients (39.3%) showed residual change associated with stent-induced ductal change, the degree of which was partial improvement, no change, and obstructive change in one, seven, and three patients, respectively. Stricture changes during stent removal and duration of stent placement that triggered ductal changes were significantly associated with the development of residual ductal changes.</p><p><strong>Conclusions: </strong>Irreversible stent-induced ductal change in patients with chronic pancreatitis was associated with stricture changes in the main pancreatic duct and continued plastic-stent placement. Careful evaluation of the pancreatic duct is required during plastic-stent placement. Early plastic-stent removal may result in an effective response to the development of stent-induced ductal change.</p>","PeriodicalId":15877,"journal":{"name":"Journal of Gastroenterology and Hepatology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142125939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical guidance for cannabidiol-associated hepatotoxicity: A narrative review. 大麻二酚相关肝毒性临床指南:叙述性综述。
IF 3.7 3区 医学
Journal of Gastroenterology and Hepatology Pub Date : 2024-09-03 DOI: 10.1111/jgh.16730
Lauren Eadie, Lindsay A Lo, Michael Boivin, Jagpaul K Deol, Caroline A MacCallum
{"title":"Clinical guidance for cannabidiol-associated hepatotoxicity: A narrative review.","authors":"Lauren Eadie, Lindsay A Lo, Michael Boivin, Jagpaul K Deol, Caroline A MacCallum","doi":"10.1111/jgh.16730","DOIUrl":"https://doi.org/10.1111/jgh.16730","url":null,"abstract":"<p><p>There is increasing evidence that cannabidiol (CBD) use is associated with clinically significant liver enzyme (LE) elevations and drug-induced liver injury (DILI). The proportion of LE elevations and DILI events reported in the literature meet the Council for International Organizations of Medical Sciences' (CIOMS) classification of a common adverse drug reaction. However, these potential adverse events are unknown to many clinicians and may be overlooked. The increasing use of CBD for both medical and non-medical use necessitates clear direction in the diagnosis and management of CBD-associated hepatotoxicity. To our knowledge, no such clinical guidance currently exists. For people presenting with elevated LEs, CBD use should be screened for and be considered in the differential diagnosis. This narrative review will provide clinicians with guidance in the prevention, detection, and management of CBD-related hepatotoxicity.</p>","PeriodicalId":15877,"journal":{"name":"Journal of Gastroenterology and Hepatology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142125938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gastrointestinal: Annular pancreas: duodenal ampulla cancer. 胃肠道:环状胰腺:十二指肠瓿癌。
IF 3.7 3区 医学
Journal of Gastroenterology and Hepatology Pub Date : 2024-08-27 DOI: 10.1111/jgh.16691
J Cao, L Sha, J Wang
{"title":"Gastrointestinal: Annular pancreas: duodenal ampulla cancer.","authors":"J Cao, L Sha, J Wang","doi":"10.1111/jgh.16691","DOIUrl":"https://doi.org/10.1111/jgh.16691","url":null,"abstract":"","PeriodicalId":15877,"journal":{"name":"Journal of Gastroenterology and Hepatology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142080561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lower hepatocellular carcinoma surveillance in metabolic dysfunction-associated steatotic liver disease: Impact on treatment eligibility. 降低代谢功能障碍相关脂肪性肝病的肝细胞癌监测率:对治疗资格的影响。
IF 3.7 3区 医学
Journal of Gastroenterology and Hepatology Pub Date : 2024-08-27 DOI: 10.1111/jgh.16727
Connor Henry-Blake, Vinay Balachandrakumar, Mohamed Kassab, Joshua Devonport, Charmaine Matthews, James Fox, Elisabeth Baggus, Alexander Henney, Nicholas Stern, Daniel J Cuthbertson, Daniel Palmer, Philip J Johnson, David M Hughes, Theresa J Hydes, Timothy J S Cross
{"title":"Lower hepatocellular carcinoma surveillance in metabolic dysfunction-associated steatotic liver disease: Impact on treatment eligibility.","authors":"Connor Henry-Blake, Vinay Balachandrakumar, Mohamed Kassab, Joshua Devonport, Charmaine Matthews, James Fox, Elisabeth Baggus, Alexander Henney, Nicholas Stern, Daniel J Cuthbertson, Daniel Palmer, Philip J Johnson, David M Hughes, Theresa J Hydes, Timothy J S Cross","doi":"10.1111/jgh.16727","DOIUrl":"https://doi.org/10.1111/jgh.16727","url":null,"abstract":"<p><strong>Background and aim: </strong>This study aimed to compare the determinants and impact of hepatocellular carcinoma (HCC) surveillance rates for people with metabolic dysfunction-associated steatotic liver disease (MASLD) versus other chronic liver diseases.</p><p><strong>Methods: </strong>A dataset of HCC patients from a UK hospital (2007-2022) was analyzed. The Mann-Whitney U-test compared continuous variables. The χ<sup>2</sup> and two-tailed Fisher exact tests compared categorical data. Regression modeling analyzed the impact of MASLD on the size and number of HCC nodules and curative treatment. The Cox proportional hazards model assessed the influence of MASLD on overall survival.</p><p><strong>Results: </strong>A total of 176 of 687 (25.6%) HCC patients had MASLD. Fewer people with MASLD HCC were enrolled in HCC surveillance compared to non-MASLD HCC (38 [21.6%] vs 215 [42.1%], P < 0.001). Patients with MASLD HCC were less likely to have been under secondary care (n = 57 [32.4%] vs 259 [50.7%], P < 0.001) and less likely to have cirrhosis (n = 113 [64.2%] vs 417 [81.6%], P < 0.001). MASLD was associated with a 12.3-mm (95% confidence interval [CI] 10.8-14.0 mm) greater tumor diameter compared to people without MASLD (P = 0.002). Patients with MASLD HCC had 0.62 reduced odds (95% CI 0.43-0.91) of receiving curative treatment compared to non-MASLD HCC (P = 0.014). Overall survival was similar for patients with MASLD HCC versus non-MASLD HCC (hazard ratio 1.03, 95% CI 0.85-1.25, P = 0.748).</p><p><strong>Conclusion: </strong>Patients with MASLD are less likely to have been enrolled in HCC surveillance due to undiagnosed cirrhosis or presenting with non-cirrhotic HCC. Patients with MASLD HCC present with larger tumors and are less likely to receive curative treatment.</p>","PeriodicalId":15877,"journal":{"name":"Journal of Gastroenterology and Hepatology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142080562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Letter to the editor: In vitro digestion and radiolabeling characteristics of Vital® for gastric emptying scintigraphy. 致编辑的信:用于胃排空闪烁成像的 Vital® 的体外消化和放射性标记特性。
IF 3.7 3区 医学
Journal of Gastroenterology and Hepatology Pub Date : 2024-08-26 DOI: 10.1111/jgh.16729
N Tagiling, H W Ngo, N-F Sahran, M D Mohamad Kamarulzaman, Mp-K Wong, N Mustaffa, S H Syed Abd Aziz, Y Y Lee, N Mat Nawi
{"title":"Letter to the editor: In vitro digestion and radiolabeling characteristics of Vital<sup>®</sup> for gastric emptying scintigraphy.","authors":"N Tagiling, H W Ngo, N-F Sahran, M D Mohamad Kamarulzaman, Mp-K Wong, N Mustaffa, S H Syed Abd Aziz, Y Y Lee, N Mat Nawi","doi":"10.1111/jgh.16729","DOIUrl":"https://doi.org/10.1111/jgh.16729","url":null,"abstract":"","PeriodicalId":15877,"journal":{"name":"Journal of Gastroenterology and Hepatology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142073023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Efficacy and safety of tegoprazan- and rabeprazole-based concomitant therapies for Helicobacter pylori infection: Real-world evidence. 以替戈拉赞和雷贝拉唑为基础的幽门螺杆菌感染联合疗法的有效性和安全性:真实世界的证据。
IF 3.7 3区 医学
Journal of Gastroenterology and Hepatology Pub Date : 2024-08-26 DOI: 10.1111/jgh.16719
Byung Wook Jung, Chan Hyuk Park, Yoon Suk Jung
{"title":"Efficacy and safety of tegoprazan- and rabeprazole-based concomitant therapies for Helicobacter pylori infection: Real-world evidence.","authors":"Byung Wook Jung, Chan Hyuk Park, Yoon Suk Jung","doi":"10.1111/jgh.16719","DOIUrl":"https://doi.org/10.1111/jgh.16719","url":null,"abstract":"<p><strong>Background and aim: </strong>Tegoprazan, a novel potassium-competitive acid blocker, has been approved for Helicobacter pylori eradication in Korea. We compared the efficacy and safety of tegoprazan- and rabeprazole-based concomitant therapies for H. pylori eradication in real-world clinical practice.</p><p><strong>Methods: </strong>We retrospectively analyzed data from patients with H. pylori infection treated with tegoprazan- or rabeprazole-based concomitant therapies. The primary endpoint was H. pylori eradication rate. The secondary endpoint was adverse events.</p><p><strong>Results: </strong>Among the 1474 included patients, 620 and 854 received tegoprazan- and rabeprazole-based concomitant therapies, respectively. Intention-to-treat analysis showed no significant difference in the eradication rates between the tegoprazan- and rabeprazole-based concomitant therapy groups (74.7% [95% confidence interval [CI], 71.1-78.0%] vs 72.7% [95% CI, 69.7-75.6%], P = 0.400). Per-protocol analysis also demonstrated similar eradication rates for the groups (tegoprazan vs rabeprazole: 88.0% [95% CI, 85.0-90.6%] vs 85.9% [95% CI, 83.2-88.3%], P = 0.288). Although the overall adverse event rate did not differ between groups (tegoprazan vs rabeprazole, 39.2% vs 40.6%, P = 0.578), abdominal discomfort was less frequent in the tegoprazan group than in the rabeprazole group (1.3 vs 4.8%, P = 0.001).</p><p><strong>Conclusions: </strong>Tegoprazan- and rabeprazole-based concomitant therapies for H. pylori eradication showed comparable efficacy and overall safety. The effect of tegoprazan on dose increases or other regimens, such as bismuth-containing quadruple therapy, should be further evaluated, because the efficacy of tegoprazan-based concomitant therapy may be suboptimal in regions where the clarithromycin resistance rate is high.</p>","PeriodicalId":15877,"journal":{"name":"Journal of Gastroenterology and Hepatology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142073022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Regression of liver fibrosis after HBsAg loss: A prospective matched case-control evaluation using transient elastography and serum enhanced liver fibrosis test. HBsAg 消失后肝纤维化的消退:使用瞬时弹性成像和血清增强肝纤维化测试进行前瞻性匹配病例对照评估。
IF 3.7 3区 医学
Journal of Gastroenterology and Hepatology Pub Date : 2024-08-26 DOI: 10.1111/jgh.16728
Lung-Yi Mak, Rex Wan-Hin Hui, Matthew S H Chung, Danny Ka-Ho Wong, James Fung, Wai-Kay Seto, Man-Fung Yuen
{"title":"Regression of liver fibrosis after HBsAg loss: A prospective matched case-control evaluation using transient elastography and serum enhanced liver fibrosis test.","authors":"Lung-Yi Mak, Rex Wan-Hin Hui, Matthew S H Chung, Danny Ka-Ho Wong, James Fung, Wai-Kay Seto, Man-Fung Yuen","doi":"10.1111/jgh.16728","DOIUrl":"https://doi.org/10.1111/jgh.16728","url":null,"abstract":"<p><strong>Background and aim: </strong>We assessed the effect of hepatitis B surface antigen (HBsAg) seroclearance (HBsAg-loss) on liver fibrosis regression in patients with chronic hepatitis B (CHB) infection.</p><p><strong>Method: </strong>CHB patients with recent documented HBsAg-loss were age- and gender-matched with treatment-naïve HBeAg-negative CHB infection. Paired assessment with transient elastography and enhanced liver fibrosis (ELF) measurements were performed and repeated at 3 years. Fibrosis regression was arbitrarily defined as decrease in ≥ 1 fibrosis stage by ELF, or combining with reduction > 30% in liver stiffness.</p><p><strong>Results: </strong>A total of 142 HBsAg-loss and 142 CHB subjects were recruited (median age 58.1 years, 51.4% male). A total of 1.8% (1.4% HBsAg-loss vs 2.1% CHB) achieved combined endpoint of fibrosis regression at 3 years. When ELF-only definition of fibrosis regression was used, 14.5% HBsAg-loss and 16.9% CHB subjects achieved this endpoint, which was significantly associated with baseline ELF (hazard ratio (HR) 1.827, 95% confidence interval (CI) 1.085-3.075) and time since HBsAg-loss (HR 2.688, 95% CI 1.257-5.748). While increasing time since HBsAg-loss increased the proportion of ELF-defined fibrosis regression, increasing age was also associated with significant fibrosis. Age of achieving HBsAg-loss (ageSC) was independently associated with high baseline ELF values. Up to 52.3% and 63.8% subjects with ageSC > 50 had advanced fibrosis/cirrhosis at baseline and 3 years, respectively, compared with 5.9% and 20.6% in subjects with ageSC < 50.</p><p><strong>Conclusion: </strong>Fibrosis regression occurred in a minority of subjects achieving HBsAg-loss, which was not significantly different compared with subjects with persistent overt CHB. Subjects after achieving HBsAg-loss, especially among those with ageSC > 50, should receive ongoing surveillance for liver-related complications.</p>","PeriodicalId":15877,"journal":{"name":"Journal of Gastroenterology and Hepatology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142073024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effectiveness of high-dose esomeprazole or pantoprazole 10-day sequential therapy empirically prescribed in Helicobacter pylori-infected naïve patients: a retrospective study. 对幽门螺旋杆菌感染的新患者采用大剂量埃索美拉唑或泮托拉唑 10 天序贯疗法的有效性:一项回顾性研究。
IF 3.7 3区 医学
Journal of Gastroenterology and Hepatology Pub Date : 2024-08-26 DOI: 10.1111/jgh.16731
Matteo Pavoni, Giulia Fiorini, Angelo Zullo, Ilaria Maria Saracino, Luigi Gatta, Raffaele Manta, Andrea Imbrogno, Tiziana Lazzarotto, Claudio Borghi, Dino Vaira
{"title":"Effectiveness of high-dose esomeprazole or pantoprazole 10-day sequential therapy empirically prescribed in Helicobacter pylori-infected naïve patients: a retrospective study.","authors":"Matteo Pavoni, Giulia Fiorini, Angelo Zullo, Ilaria Maria Saracino, Luigi Gatta, Raffaele Manta, Andrea Imbrogno, Tiziana Lazzarotto, Claudio Borghi, Dino Vaira","doi":"10.1111/jgh.16731","DOIUrl":"https://doi.org/10.1111/jgh.16731","url":null,"abstract":"<p><strong>Background and aim: </strong>Helicobacter pylori infection is one of the most common bacterial infections affecting humans, causing gastroduodenal and extraintestinal diseases. Treatment of the infection remains challenging for the clinicians, and different factors are involved in the failure of the therapeutic approach. The importance of the intensity of acid secretion inhibition remains an unclear issue. The aim of this study is to assess whether 80 mg/day esomeprazole-based 10-day sequential therapy (esomeprazole-ST) achieved different eradication rates when compared to 80 mg/day pantoprazole-based analogous regimen (pantoprazole-ST).</p><p><strong>Methods: </strong>This was a retrospective observational study where data of consecutive patients referred by their physicians to our unit to perform an upper gastrointestinal endoscopy were analyzed.</p><p><strong>Results: </strong>Overall, 1,327 patients were available for the analysis: 599 and 728 patients received pantoprazole-ST and esomeprazole-ST, respectively. Eradication rate was significantly higher in patients receiving esomeprazole-ST (92.6%, 95% CI: 91-94.5) than pantoprazole-ST (89.3%, 95% CI: 86.7-91.7; difference: 3.3%; 95% CI: 0.2-6.5; P = 0.037). Even after a multivariate analysis, the esomeprazole-ST achieved a significantly higher eradiation (OR: 1.44; 95% CI: 1.1-2.17).</p><p><strong>Conclusions: </strong>This study showed that esomeprazole-ST achieved significantly higher H. pylori cure rates than pantoprazole-ST. Prospective and well-designed trials are demander to confirm this prelaminar finding.</p>","PeriodicalId":15877,"journal":{"name":"Journal of Gastroenterology and Hepatology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142073012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Rituximab carries high risks of hepatitis B virus reactivation in hematologic and rheumatic patients with chronic or resolved hepatitis B. 利妥昔单抗对患有慢性或已治愈乙型肝炎的血液病和风湿病患者具有乙型肝炎病毒再激活的高风险。
IF 3.7 3区 医学
Journal of Gastroenterology and Hepatology Pub Date : 2024-08-24 DOI: 10.1111/jgh.16725
Kuan-Chu Hou, Tung-Hung Su, Chien-Neng Kao, Huei-Ru Cheng, Tai-Chung Tseng, Chun-Jen Liu, Song-Chou Hsieh, Jia-Horng Kao
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