Journal of Gastroenterology and Hepatology最新文献

{"title":"Nonlinear Trend and Inequality Analysis of Colorectal Cancer Burden From 1990 to 2021: Insights From the Global Burden of Disease Study 2021","authors":"Yunduo Zhou, Ruilong Hao","doi":"10.1111/jgh.16976","DOIUrl":"10.1111/jgh.16976","url":null,"abstract":"","PeriodicalId":15877,"journal":{"name":"Journal of Gastroenterology and Hepatology","volume":"40 6","pages":"1642-1643"},"PeriodicalIF":3.7,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144027934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hereditary Gastrointestinal Cancer Syndromes and Early-Onset Gastrointestinal Cancers","authors":"Rashid N. Lui, Han-Mo Chiu","doi":"10.1111/jgh.16965","DOIUrl":"https://doi.org/10.1111/jgh.16965","url":null,"abstract":"<p>Gastroenterologists are frequently at the forefront of patient care for patients with hereditary gastrointestinal (GI) cancer syndromes. Familiarity to the main hereditary colorectal cancer (HCRC) syndromes such as Lynch syndrome (LS) and familial adenomatous polyposis (FAP) and understanding the genotype/phenotype relationship are paramount for recommending personalized management and surveillance. Furthermore, it would be considered good practice to refer patients and family members to dedicated cancer genetic services for genetic counseling, address specific concerns associated with each genetic susceptibility, and for cascade testing if appropriate [<span>1</span>].</p><p>In recent issues of the <i>Journal of Gastroenterology and Hepatology</i>, several studies have been published that shed further light on hereditary GI cancer syndromes. First, lifestyle and environmental risk factors still play an important role in disease burden for this patient group. A Korean study found that apart from high baseline polyp burden of > 100 polyps and specific genetic mutations, exposure to smoking independently predicted a high risk of increased polyp burden in patients with suspected polyposis syndrome. A similar finding was found for patients with LS where patients who smoked had CRC at a younger age, and heavy drinkers had a high risk of CRC and any cancer [<span>2</span>]. This suggests that lifestyle modification such as smoking cessation and alcohol abstinence not only reduces the risk of sporadic CRC but may also play a prominent role in reducing the risk of HCRC. Second, there are some differences in the cancer surveillance guidelines for LS that may cause confusion and difficulty for clinicians. This includes the age to begin CRC screening, recommendations on gynecological surveillance and modalities, urological surveillance, recommendations for surgery, and chemoprophylaxis strategies [<span>3</span>]. Third, the prevalence and incidence of Peutz–Jeghers syndrome (PJS) and juvenile polyposis syndrome (JPS) in Japan were determined for the first time. In 2021, the prevalence of PJS and JPS were 0.6/100000 and 0.15/100000, respectively, and the incidence of PJS and JPS were 0.07/100000 and 0.02/100000, respectively [<span>4</span>]. In Korean polyposis patients (≥ 10 biopsy-proven cumulative polyps) but without germline mutations for known HCRC syndromes, genome-wide association studies revealed 71 novel risk single-nucleotide polymorphisms (SNPs). Two novel genes (<i>CNTN4</i> and <i>CNTNAP3B</i>) were identified, and three SNPs (rs149368557, rs12438834, and rs9707935) were associated with a higher risk of polyposis recurrence [<span>5</span>]. This implies that ethnic and regional variations may exist and emphasizes the importance of identifying the polygenic risk profile of these low to medium penetrant genes and their cumulative effects on the risk of CRC.</p><p>Moving on to sporadic GI cancers, there has been a plethora of studies that ","PeriodicalId":15877,"journal":{"name":"Journal of Gastroenterology and Hepatology","volume":"40 5","pages":"1037-1039"},"PeriodicalIF":3.7,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jgh.16965","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143926063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Strengthening Predictive Models and Risk Assessment in Autoimmune Gastritis: A Critical Appraisal","authors":"Eisha Abid, Areeba Abid, Hiba Abid, Syed Ibad Hussain, Amna Amir Jalal","doi":"10.1111/jgh.16967","DOIUrl":"10.1111/jgh.16967","url":null,"abstract":"","PeriodicalId":15877,"journal":{"name":"Journal of Gastroenterology and Hepatology","volume":"40 6","pages":"1631-1632"},"PeriodicalIF":3.7,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144013659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Novel Clip Device for Safer and Faster Suturing in Endoscopic Papillectomy: A Retrospective Study of 241 Procedures","authors":"Kohei Takano,&nbsp;Kentaro Yamao,&nbsp;Takuya Ishikawa,&nbsp;Yoshihisa Takada,&nbsp;Yasuyuki Mizutani,&nbsp;Tadashi Iida,&nbsp;Kota Uetsuki,&nbsp;Takeshi Yamamura,&nbsp;Yoji Ishizu,&nbsp;Kazuhiro Furukawa,&nbsp;Takashi Honda,&nbsp;Masanao Nakamura,&nbsp;Hiroki Kawashima","doi":"10.1111/jgh.16963","DOIUrl":"https://doi.org/10.1111/jgh.16963","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background and Aim</h3>\u0000 \u0000 <p>Endoscopic papillectomy (EP) is a minimally invasive treatment for ampullary neoplasms. However, traditional endoscopic clips used for hemostasis and suturing during EP are often difficult to manipulate because of limitations in maneuverability. To address this issue, the efficacy of a novel clip was evaluated for its potential to improve suturing and reduce procedure difficulty after EP.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This retrospective study included 241 patients who underwent EP at Nagoya University Hospital between December 2004 and April 2024. Patients were divided into two groups: the conventional clip group (<i>n</i> = 184) and the novel clip group (<i>n</i> = 57). We compared the total clipping time, number of clips used, and incidence of adverse events between the two groups.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The total clipping time was significantly shorter in the novel clip group than in the conventional clip group (6.0 vs. 12.7 min, <i>p</i> &lt; 0.01). The novel clip group also required fewer clips for suturing (3.9 vs. 5.0 clips, <i>p</i> &lt; 0.01) and had fewer dislodged clips at the second look endoscopy (0.05 vs. 0.72 clips, <i>p</i> &lt; 0.01). There was no significant difference in the delayed bleeding rate between the two groups (5.3% vs. 8.7%, <i>p</i> = 0.58).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The novel clip demonstrated superior performance in terms of reducing the procedure time, the number of clips used, and the incidence of clip dislodgement in suturing after EP. This offers a promising solution for improving procedural efficiency. In conclusion, the novel clip should be used in wound suturing after EP.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15877,"journal":{"name":"Journal of Gastroenterology and Hepatology","volume":"40 5","pages":"1238-1244"},"PeriodicalIF":3.7,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143926107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond Identified Risk Factors: Exploring Diet, Microbial Dysbiosis, and Immune Crosstalk in Autoimmune Gastritis","authors":"Yadi Li,&nbsp;Xinmei Gao,&nbsp;Xinmin Deng","doi":"10.1111/jgh.16970","DOIUrl":"10.1111/jgh.16970","url":null,"abstract":"","PeriodicalId":15877,"journal":{"name":"Journal of Gastroenterology and Hepatology","volume":"40 6","pages":"1638-1639"},"PeriodicalIF":3.7,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144022359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to Editor: Comments on NLRP3 and Gut–Liver Axis: New Possibility for the Treatment of Alcohol-Associated Liver Disease","authors":"Muhammad Adnan,&nbsp;Khalil Ullah Khan,&nbsp;Sohaib Raza,&nbsp;Shah Rukh Rehman,&nbsp;Muzamil Ahmed","doi":"10.1111/jgh.16979","DOIUrl":"10.1111/jgh.16979","url":null,"abstract":"","PeriodicalId":15877,"journal":{"name":"Journal of Gastroenterology and Hepatology","volume":"40 6","pages":"1648-1649"},"PeriodicalIF":3.7,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144023210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PCED1A as a Predictive Biomarker for Immunotherapy and Anti-Angiogenic Treatment in Hepatocellular and Colorectal Cancer","authors":"Valbert Oliveira Costa Filho,&nbsp;Pedro Robson Costa Passos","doi":"10.1111/jgh.16969","DOIUrl":"10.1111/jgh.16969","url":null,"abstract":"","PeriodicalId":15877,"journal":{"name":"Journal of Gastroenterology and Hepatology","volume":"40 6","pages":"1635-1637"},"PeriodicalIF":3.7,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143983640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Depression or Anxiety in GI Outpatients: Upper GI Symptoms and Symptom Clusters Showed Stronger Associations Than Lower GI","authors":"Zhiyue Xu,&nbsp;Shengyan Zhang,&nbsp;Saier Li,&nbsp;Shu Xu,&nbsp;Dongke Wang,&nbsp;Siran Zhu,&nbsp;Xinghuang Liu,&nbsp;Jun Song,&nbsp;Jingsong Liu,&nbsp;Xiaohua Hou,&nbsp;Tao Bai,&nbsp;Likun Zhong","doi":"10.1111/jgh.16955","DOIUrl":"10.1111/jgh.16955","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background and Aim</h3>\u0000 \u0000 <p>Gastrointestinal (GI) problems have been always linked to psychiatric disorders. The aim of our study was to explore specific GI symptoms or symptom clusters that may indicate the presence of depression or anxiety in outpatients.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>One thousand one hundred twenty-five outpatients from 20 hospitals completed questionnaires assessing GI symptoms, depression (the Patient Health Questionnaire-9, PHQ-9), and anxiety (General Anxiety Disorder-7, GAD-7). Principal component analysis was employed to identify symptom clusters based on 22 GI symptoms. The patients were categorized into three groups: Control (PHQ-9 &lt; 5 and GAD-7 &lt; 5), DA1 (5 ≤ PHQ-9 &lt; 10 or/and 5 ≤ GAD-7 &lt; 10), and DA2 (PHQ-9 ≥ 10 or GAD-7 ≥ 10).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>There were 781, 249, and 95 patients in the group of Control, DA1, and DA2, respectively. Fecal incontinence (4.835, [2.213–10.563]), heartburn (3.338, [2.416–4.611]), belching (2.862, [2.145–3.821]), and globus sensation (2.845, [2.110–3.837]) demonstrated the highest potential risk of psychiatric comorbidity. The 22 GI symptoms were categorized into eight clusters. Dyspepsia-related Cluster F2, reflux-related Cluster F3, and esophageal-related Cluster F4 were noteworthy in the identification of psychiatric comorbidity. Cluster F4, including globus sensation, discomfort with swallowing, and chest pain, exhibited the most significant increase in the prevalence of depression or anxiety (2.645, [1.851–3.778]).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Specific GI symptoms including heartburn, belching, globus sensation, and GI symptom clusters including F2, F3, and F4 were noteworthy in the identification of psychiatric comorbidity. They were mostly focused on the upper GI tract. It is critical for gastroenterologists to recognize psychiatric comorbidities and implement appropriate measures accordingly.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15877,"journal":{"name":"Journal of Gastroenterology and Hepatology","volume":"40 6","pages":"1492-1499"},"PeriodicalIF":3.7,"publicationDate":"2025-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143795509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endoscopic Ultrasound–Guided Gastrojejunostomy as a Primary Treatment Modality for Malignant Gastric Outlet Obstruction: A Large Multicenter Experience","authors":"Nikhil Sonthalia,&nbsp;Radhika Chavan,&nbsp;Pankaj Singh,&nbsp;Jimmy Narayan,&nbsp;Sukrit Sud,&nbsp;Chirag N. Shah,&nbsp;Shankar Zanwar,&nbsp;Awanish Tewari,&nbsp;Sanjay Rajput,&nbsp;Vikas Singla,&nbsp;Akash Roy,&nbsp;Shanky Koul,&nbsp;Akash Goel,&nbsp;Uday C. Ghoshal,&nbsp;Mahesh Kumar Goenka","doi":"10.1111/jgh.16959","DOIUrl":"10.1111/jgh.16959","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>This work aims to describe technical feasibility and clinical outcomes of endoscopic-ultrasound-guided gastrojejunostomy (EUS-GJ) as a first line treatment option for malignant gastric outlet obstruction (mGOO).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This is a large multicenter study where patients undergoing EUS-GJ across seven tertiary care centers from India were analyzed. The primary outcomes were technical success defined as correct stent placement without any leak, and clinical success defined as improvement in gastric outlet obstruction symptom score (GOOSS) on follow-up. Secondary outcomes were (a) adverse events rates, (b) symptoms recurrence, (c) death on follow-up, and (d) resumption of chemotherapy.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of 71 patients underwent EUS-GJ with technical success of 94.3%. After successful stent placement, all patients tolerated oral liquid diet on day 1, whereas 89.5% and 95.5% tolerated oral solid diet on day 2 and day 7, respectively. Overall, 9/71(12.6%) patients had major adverse events, which included maldeployment in 6/71(8.4%). Mean duration of follow-up was 76.13 ± 58.09 days. On follow-up, reintervention was required in two (3%) patients. Around two-thirds of patients gained weight and could resume their chemotherapy post-EUS-GJ. Kaplan–Meier survival analysis showed that post EUS-GJ, mean overall survival (symptom recurrence or death) of 144.39 ± 11.53 days (95% CI 121.7–167.0).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>EUS-GJ is an excellent modality for the palliation of mGOO, providing high clinical success with extremely low rates of reintervention and acceptable safety profile. It should be considered as a primary modality for managing these patients, and enteral stent should be reserved for patients where EUS-GJ is not possible.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15877,"journal":{"name":"Journal of Gastroenterology and Hepatology","volume":"40 6","pages":"1515-1524"},"PeriodicalIF":3.7,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143780224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bifidobacterium Lactobacillus Triple Viable Alleviates Slow Transit Constipation by Regulating Gut Microbiota and Metabolism","authors":"Mei Luo,&nbsp;Peiwei Xie,&nbsp;Xuehong Deng,&nbsp;Jiahui Fan,&nbsp;Lishou Xiong","doi":"10.1111/jgh.16960","DOIUrl":"10.1111/jgh.16960","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Gut microbiota plays a crucial role in the pathogenesis and treatment of functional constipation (FC). The aim of this study was to explore the therapeutic effects of Bifidobacterium Lactobacillus triple viable on slow transit constipation (STC).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Patients with STC who met the Rome IV criteria received Bifidobacterium Lactobacillus triple viable. Gastrointestinal transit time (GITT) and constipation-related symptoms were assessed before and after receiving Bifidobacterium Lactobacillus triple viable. Additionally, a rat STC model was induced by loperamide and was treated with Bifidobacterium Lactobacillus triple viable to evaluate whether Bifidobacterium Lactobacillus triple viable could improve constipation in the rats and to explore the possible mechanisms involved.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>In patients with STC, Bifidobacterium Lactobacillus triple viable accelerated GITT and improved constipation-related symptoms, including bowel movement frequency, hard bowel movement, incomplete defecation, defecation time, purgative measures, and stool form. In addition, Bifidobacterium Lactobacillus triple viable improved body weight, food intake, bowel movement, the fecal water content, and the intestinal propulsion rate in STC rats. It regulates the gut microbiota structure in rats; increases serum acetylcholine (Ach), 5-hydroxytryptamine (5-HT), substance P (SP), and vasoactive intestinal peptide (VIP); increases fecal long-chain fatty acids (LCFAs); upregulates the mRNA expression of aquaporin 3 (AQP3) and aquaporin 3 (AQP8); and downregulates the mRNA expression of Toll-like receptor 2 (TLR2), Toll-like receptor 4 (TLR4), and interleukin-1β (IL-1β).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Bifidobacterium Lactobacillus triple viable ameliorated the GITT and constipation-related symptoms of patients with STC and improved the STC in rats by regulating the gut microbiota and metabolism.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15877,"journal":{"name":"Journal of Gastroenterology and Hepatology","volume":"40 6","pages":"1561-1573"},"PeriodicalIF":3.7,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jgh.16960","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143780222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}