Journal of Gastroenterology and Hepatology最新文献

{"title":"m6A Modification-Mediated Regulation of DCAF13 Promotes Glycolytic Metabolism and Drives Hepatocellular Carcinoma Progression via Interaction With G6PD","authors":"Chao Liu,&nbsp;Guanyuan Chen,&nbsp;Jie Liao,&nbsp;Dan Wu,&nbsp;Xu Chen,&nbsp;Na Wang","doi":"10.1111/jgh.70015","DOIUrl":"10.1111/jgh.70015","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Hepatocellular carcinoma (HCC) is a highly aggressive malignancy with poor prognosis due to enhanced glycolytic metabolism and tumor heterogeneity. Identifying key regulators of glycolysis may provide novel therapeutic targets.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We investigated the role of DCAF13 in HCC using bioinformatics analysis, CRISPR/Cas9-mediated knockout, overexpression assays, in vitro and in vivo functional studies, and molecular dynamics simulations. m6A modification of DCAF13 was analyzed through MeRIP-qPCR and RIP assays.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>DCAF13 was significantly upregulated in HCC tissues and associated with poor prognosis. Functional assays revealed that DCAF13 promotes HCC cell proliferation, migration, invasion, and tumor growth. Mechanistically, DCAF13 directly interacts with glucose-6-phosphate dehydrogenase (G6PD), enhancing glycolytic flux. Molecular dynamics simulations confirmed the stability of the DCAF13–G6PD complex. Furthermore, METTL3-mediated m6A modification and YTHDF1 binding stabilized DCAF13 mRNA, maintaining its high expression. Silencing METTL3 or YTHDF1 reduced DCAF13 levels and impaired its oncogenic function.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>We identified a METTL3–DCAF13–YTHDF1–G6PD axis that promotes glycolytic reprogramming and HCC progression. DCAF13 may serve as a promising biomarker and therapeutic target for metabolic intervention in HCC.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15877,"journal":{"name":"Journal of Gastroenterology and Hepatology","volume":"40 9","pages":"2311-2323"},"PeriodicalIF":3.4,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144707722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adrenal Insufficiency in Inflammatory Bowel Disease: A Call for Personalized Approaches and Multidisciplinary Management in Steroid Therapy","authors":"Amina Hassan,&nbsp;Javed Iqbal","doi":"10.1111/jgh.70023","DOIUrl":"10.1111/jgh.70023","url":null,"abstract":"","PeriodicalId":15877,"journal":{"name":"Journal of Gastroenterology and Hepatology","volume":"40 9","pages":"2335-2336"},"PeriodicalIF":3.4,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144698718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Remarks on the Visibility and Performance of Small Bowel Video Capsule Endoscopy With and Without Preparation in the Same Patients","authors":"Soban Ahmed Qureshi,&nbsp;Sohaib Raza,&nbsp;Muhammad Adnan,&nbsp;Muzzamil Ahmed,&nbsp;Khalil Ullah Khan","doi":"10.1111/jgh.70024","DOIUrl":"10.1111/jgh.70024","url":null,"abstract":"","PeriodicalId":15877,"journal":{"name":"Journal of Gastroenterology and Hepatology","volume":"40 9","pages":"2337-2338"},"PeriodicalIF":3.4,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144698723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Steatotic Liver Disease-Related Polygenetic Risk Score Prediction of Hepatocellular Carcinoma in Nucleotide/Nucleoside Analog-Treated Chronic Hepatitis B","authors":"Tyng-Yuan Jang,&nbsp;Chih-Wen Wang,&nbsp;Po-Cheng Liang,&nbsp;Yu-Ju Wei,&nbsp;Ming-Lun Yeh,&nbsp;Yi-Hung Lin,&nbsp;Chao-Kuan Huang,&nbsp;Pei-Chien Tsai,&nbsp;Yu-Min Ko,&nbsp;Yi-Shan Tsai,&nbsp;Kuan-Yu Chen,&nbsp;Ching-Chih Lin,&nbsp;Zu-Yau Lin,&nbsp;Jee-Fu Huang,&nbsp;Chia-Yen Dai,&nbsp;Chung-Feng Huang,&nbsp;Wan-Long Chuang,&nbsp;Ming-Lung Yu","doi":"10.1111/jgh.70021","DOIUrl":"10.1111/jgh.70021","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background and Aims</h3>\u0000 \u0000 <p>We aimed to investigate the association between steatotic liver disease-related genetic risk and hepatocellular carcinoma (HCC) in Taiwanese patients with chronic hepatitis B (CHB) treated with nucleotide/nucleoside analogs (NAs).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We enrolled 745 Taiwanese patients with CHB treated with NAs and analyzed the incidence and risk factors for HCC. Steatotic liver disease (SLD)–related single nucleotide polymorphisms (SNPs) were tested, and a polygenetic risk score (PRS) for hepatocellular carcinoma was created.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The annual incidence of HCC was 1.7/100 person-years after a follow-up of &gt; 3346.9 person-years. Factors with the strongest association with HCC were liver cirrhosis (hazard ratio [HR]/95% confidence interval [CI]: 4.51/2.12–9.62; <i>p</i> &lt; 0.001), followed by male sex (4.20/1.64–10.79; <i>p</i> = 0.003), a sSLD-related PRS &gt; 0.062 (2.24/1.09–4.58; <i>p</i> = 0.03), body mass index (BMI) (1.15/1.07–1.24; <i>p</i> &lt; 0.001), and age (1.06/1.03–1.10; <i>p</i> &lt; 0.001). Among patients without cirrhosis, the HCC-associated factors were male sex (HR/CI: 1.17/1.10–1.24; <i>p</i> &lt; 0.001) and BMI (1.16/1.03–1.30; <i>p</i> = 0.01). In contrast, a high PRS (HR/CI: 2.57/1.19–5.57; <i>p</i> = 0.02) was the only HCC-associated factor in patients with cirrhosis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The SLD-related gPRS predicted HCC development in CHB patients treated with NAs. The genetic effects were particularly enhanced in patients with cirrhosis.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15877,"journal":{"name":"Journal of Gastroenterology and Hepatology","volume":"40 9","pages":"2290-2299"},"PeriodicalIF":3.4,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144698724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comments on Programmed Cell Death Signature and THBS1 in Gastric Cancer: Advancing Toward Translational Clarity","authors":"F. N. U. Wajeeha,&nbsp;Sohaib Raza,&nbsp;Zernain Toor","doi":"10.1111/jgh.70035","DOIUrl":"10.1111/jgh.70035","url":null,"abstract":"","PeriodicalId":15877,"journal":{"name":"Journal of Gastroenterology and Hepatology","volume":"40 10","pages":"2642-2643"},"PeriodicalIF":3.4,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144698719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"HDAC9 as a Sex-Dependent Epigenetic Driver of Hepatic Steatosis and Adipose Inflammation","authors":"Yu Ji Kim,&nbsp;Jong-Won Kim","doi":"10.1111/jgh.70029","DOIUrl":"10.1111/jgh.70029","url":null,"abstract":"","PeriodicalId":15877,"journal":{"name":"Journal of Gastroenterology and Hepatology","volume":"40 10","pages":"2632-2633"},"PeriodicalIF":3.4,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144698721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nonsuperiority of Simultaneous Compared With Sequential Interventions in Infected Necrotic Collections at Multiple Sites in Acute Necrotizing Pancreatitis: A Randomized Trial","authors":"Bikkina Venkat Siddharda,&nbsp;Jimil Shah,&nbsp;Pankaj Gupta,&nbsp;Harish Bhujade,&nbsp;Sanish Ancil,&nbsp;Vaneet Jearth,&nbsp;Anupam K. Singh,&nbsp;Harshal S. Mandavdhare,&nbsp;Vishal Sharma,&nbsp;Yashwant Raj Sakaray,&nbsp;Harjeet Singh,&nbsp;Rajesh Gupta,&nbsp;Paraskevas Gkolfakis,&nbsp;Marianna Arvanitakis,&nbsp;Surinder Rana,&nbsp;Usha Dutta","doi":"10.1111/jgh.70010","DOIUrl":"10.1111/jgh.70010","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Patients with infected pancreatic necrosis (IPN) may need multiple interventions when the necrotic collection is multifocal. However, the efficacy of simultaneous interventions has not been compared with sequential interventions in this group of patients.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We performed a single-center, open-label, superiority, randomized trial at a tertiary-level hospital to compare simultaneous versus sequential intervention of infected necrotic collections involving at least two anatomical sites. In the simultaneous group (Group A), all sites were drained simultaneously. In the sequential group (Group B), only the largest site or the site with gas foci was drained initially. Additional interventions in either group were done based on predefined clinical criteria. The primary outcome was the Comprehensive Complication Index (CCI) until clinical success or death. Secondary outcomes were the number of interventions, major disease-related complications, and mortality. An intention-to-treat analysis was performed.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>We assessed 253 patients for eligibility, and 60 patients were enrolled (29 in Group A and 31 in Group B). The mean age was 36.9 ± 13.4 years. The mean CCI was similar among both groups (72.5 ± 28.3 vs. 64.4 ± 34.9; 95% CI, −24.59 to 8.39). The number of interventions in Group B was significantly lower (4.17 ± 2.00 vs. 2.97 ± 1.94; 95% CI, −0.18 to −2.22). Development of new-onset organ failure (34.5% vs. 38.7%), need for surgical intervention (27.5% vs. 22.5%), and mortality (41.3% vs. 38.7%) were not significantly different between the groups.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>A simultaneous intervention approach aimed at draining multiple sites is not superior to a sequential intervention approach guided by clinical outcomes in patients with IPN involving multiple sites.</p>\u0000 \u0000 <p><b>Trial Registration:</b> CTRI identifier: CTRI/2022/07/04387</p>\u0000 </section>\u0000 </div>","PeriodicalId":15877,"journal":{"name":"Journal of Gastroenterology and Hepatology","volume":"40 10","pages":"2463-2471"},"PeriodicalIF":3.4,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144698722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative Efficacy and Safety of 0.8-L Versus 2-L Polyethylene Glycol-Ascorbic Acid Solutions in Colonoscopy Preparation: A Prospective, Multicenter, Randomized, Controlled Trial","authors":"Bomee Lee,&nbsp;Bora Keum,&nbsp;Sung Noh Hong,&nbsp;Hyun Gun Kim,&nbsp;Jong Pil Im,&nbsp;Soo-Young Na,&nbsp;Min Seob Kwak,&nbsp;Kwangwoo Nam,&nbsp;Jeong-Sik Byeon","doi":"10.1111/jgh.70006","DOIUrl":"10.1111/jgh.70006","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background and Aim</h3>\u0000 \u0000 <p>High-volume polyethylene glycol (PEG) solutions are associated with low patient compliance, whereas low-volume alternatives pose higher risks of adverse events. We compared a new 0.8-L PEG–ascorbic acid solution containing simethicone to a 2-L PEG–ascorbic acid solution.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>In this prospective, investigator-blinded study, 137 outpatients from five centers were randomized into three groups: Group A (0.8-L PEG–ascorbic acid with a split-dose regimen), Group B (0.8-L PEG–ascorbic acid on the same day as the colonoscopy), and Group C (2-L PEG–ascorbic acid with a split-dose regimen). The primary outcome was the cleansing efficacy, assessed using the Harefield Cleansing Scale (HCS). Secondary outcomes included bubble score, polyp and adenoma detection rates, patient satisfaction, tolerability, and safety.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>All groups achieved 100% successful preparation (HCS grades A and B). Group B had a higher HCS grade in the ascending colon than Group C (3.2 vs. 3.0, <i>p</i> = 0.01). Groups A and B showed better bubble scores than Group C (<i>p</i> &lt; 0.0001). Polyp and adenoma detection rates were similar across the groups. Group B demonstrated the highest satisfaction score (139.1 ± 76.7), followed by Group A (129.8 ± 64.9) and Group C (125.6 ± 60.0), with no significant differences. The tolerability and safety parameters were similar between the groups.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The novel 0.8-L PEG–ascorbic acid solution was effective, safe, and highly tolerable, showing noninferiority to the 2-L PEG–ascorbic acid solution. The same-day regimen showed a tendency toward better cleansing efficacy in the ascending colon and higher patient satisfaction.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15877,"journal":{"name":"Journal of Gastroenterology and Hepatology","volume":"40 9","pages":"2248-2257"},"PeriodicalIF":3.4,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jgh.70006","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144698720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Radiofrequency Ablation Is Expected to Become One of the Standard Treatment Methods for High-Risk Gastrointestinal Metaplasia","authors":"Jing-Yu Zhu,&nbsp;Xing-Jie Shen,&nbsp;Liang Liu","doi":"10.1111/jgh.70034","DOIUrl":"10.1111/jgh.70034","url":null,"abstract":"","PeriodicalId":15877,"journal":{"name":"Journal of Gastroenterology and Hepatology","volume":"40 10","pages":"2640-2641"},"PeriodicalIF":3.4,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144690414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on “Impact of Positive Glucose, Lactose, and Fructose Hydrogen Breath Tests on Symptoms and Quality of Life in Irritable Bowel Syndrome”","authors":"Yu Yan,&nbsp;Liang Liu,&nbsp;Xing-Jie Shen","doi":"10.1111/jgh.70032","DOIUrl":"10.1111/jgh.70032","url":null,"abstract":"","PeriodicalId":15877,"journal":{"name":"Journal of Gastroenterology and Hepatology","volume":"40 10","pages":"2638-2639"},"PeriodicalIF":3.4,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144690412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}