Journal of Gastroenterology and Hepatology最新文献

{"title":"Beyond Pooled Prevalence: Validating MASLD Risk Pathways Across South Asia.","authors":"Sham Singh, Rajesh Prasad Jayaswal","doi":"10.1111/jgh.70785","DOIUrl":"https://doi.org/10.1111/jgh.70785","url":null,"abstract":"","PeriodicalId":15877,"journal":{"name":"Journal of Gastroenterology and Hepatology","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149110814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gel Immersion in Colorectal UEMR: From Improved Visibility to Clinical Benefit","authors":"Yuquan Cai, Meng Yuan, Haiyang Song, Xiaobin Sun, Lei Liu","doi":"10.1111/jgh.70660","DOIUrl":"10.1111/jgh.70660","url":null,"abstract":"","PeriodicalId":15877,"journal":{"name":"Journal of Gastroenterology and Hepatology","volume":"41 10","pages":"3230-3231"},"PeriodicalIF":3.5,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148712726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparable Predictive Performance of Non-VCTE–Based Machine Learning Model for HBV-Infected Hepatocellular Carcinoma Risk","authors":"Hahn Yi,&nbsp;Hye Won Lee,&nbsp;Jae Il Shin,&nbsp;Hyung Woong Lee,&nbsp;Tae Seop Lim,&nbsp;Beom Kyung Kim,&nbsp;Namkug Kim","doi":"10.1111/jgh.70686","DOIUrl":"10.1111/jgh.70686","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Accurate risk stratification for hepatocellular carcinoma (HCC) among chronic hepatitis B (CHB) patients remains challenging. Vibration-controlled transient elastography (VCTE) is useful for HCC prediction; however, its nationwide use might be limited in CHB-endemic or resource-limited regions. We developed and validated non-VCTE–based machine learning (ML) models for HCC prediction, integrating routine clinical and laboratory parameters.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We analyzed a multicenter cohort of CHB patients receiving entecavir or tenofovir. ML-based survival models were developed and validated, with their performance compared both with and without VCTE-derived parameters (liver stiffness measurement/controlled attenuation parameter) to analyze VCTE's role amidst routine variables. Non-VCTE–based ML models were then compared against the modified PAGE-B (mPAGE-B) score. Model performance was assessed by Uno's C-index, area under the ROC curve (AUC), and Brier score at 5-, 6-, and 7-year follow-up using cross-validation and external validation.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Among 2736 patients (training <i>n</i> = 1954; validation <i>n</i> = 782), no statistically significant difference in predictive performance was observed between ML-based models with and without VCTE-derived parameters. Non-VCTE–based ML models consistently demonstrated superior overall performance and a statistically significant difference compared to the mPAGE-B score. The non-VCTE–based RSF model demonstrated the highest discrimination (5-year C-index: 0.821; Brier score: 0.0592) in external validation. Statistically significant improvements over the mPAGE-B score were observed across all metrics except for rpCox's AUC up to 5 years.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>ML-based models provide superior long-term HCC risk prediction in CHB patients compared to the mPAGE-B score. Importantly, their performance remains robust even without VCTE-derived parameters, suggesting that effective risk stratification is achievable across diverse clinical settings, especially CHB-endemic or resource-limited regions.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15877,"journal":{"name":"Journal of Gastroenterology and Hepatology","volume":"41 10","pages":"3199-3208"},"PeriodicalIF":3.5,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148840331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pharmacokinetic and Pharmacodynamic Characteristics of Tegoprazan According to Helicobacter pylori Infection Status","authors":"Sungpil Han,&nbsp;Heechan Lee,&nbsp;Seokuee Kim,&nbsp;Hee Youn Choi,&nbsp;Yo Han Kim,&nbsp;Ji Yeon Nam,&nbsp;Bongtae Kim,&nbsp;Geun Seog Song,&nbsp;Hyeong-Seok Lim,&nbsp;Kyun-Seop Bae","doi":"10.1111/jgh.70671","DOIUrl":"10.1111/jgh.70671","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>Tegoprazan is a novel potassium-competitive acid blocker (P-CAB) used to treat acid-related diseases. This study aimed to evaluate the effect of the <i>H. pylori</i> infection status on the pharmacokinetic (PK) and pharmacodynamic (PD) characteristics and safety of tegoprazan.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This study involved two cohorts. In Cohort 1, 12 <i>H. pylori</i>-negative subjects were administered tegoprazan at 50 or 100 mg for 7 days. In Cohort 2, four subjects positive for <i>H. pylori</i> received 50 and 100 mg of tegoprazan in a single dose crossover study. We estimated the PK parameters using non-compartment analysis and measured PD parameters using an intragastric pH monitor.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The PK and PD of tegoprazan in both groups were dose-dependent. The <i>C</i>_max of each dose of tegoprazan in subjects with <i>H. pylori</i> decreased more than in the <i>H. pylori</i> negative group, but the AUC_last and AUC_inf of the two groups were similar. All PD parameters in <i>H. pylori</i>-positive subjects increased more than in the negative group, which suggests that tegoprazan's intragastric acid suppression is enhanced in cases of <i>H. pylori</i>.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The presence of <i>H. pylori</i> did not have a clinically significant effect on tegoprazan's PK and tolerability, but significantly enhanced its intragastric acid suppression efficacy.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15877,"journal":{"name":"Journal of Gastroenterology and Hepatology","volume":"41 10","pages":"3101-3108"},"PeriodicalIF":3.5,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148865375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond the Meta-Analysis: Reconsidering Class Effects, Resistance Surveillance, and Dosing Optimization in Tegoprazan-Amoxicillin Dual Therapy.","authors":"Yuxin Ye, Xinhao Pei, Jing Yang, Yu Deng, Liangyong Wan, Mingchen Huang, Ruihang Luo","doi":"10.1111/jgh.70724","DOIUrl":"10.1111/jgh.70724","url":null,"abstract":"","PeriodicalId":15877,"journal":{"name":"Journal of Gastroenterology and Hepatology","volume":" ","pages":"3319-3320"},"PeriodicalIF":3.5,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148887624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to \"Efficacy and Safety of Tegoprazan-Amoxicillin Dual Therapy for Helicobacter pylori Eradication: A Systematic Review and Meta-Analysis With Trial Sequential Analysis of Randomized Controlled Trials\".","authors":"Anisha Kumari, Guria Heerani, Vishal Kumar, Chahat Devi","doi":"10.1111/jgh.70711","DOIUrl":"10.1111/jgh.70711","url":null,"abstract":"","PeriodicalId":15877,"journal":{"name":"Journal of Gastroenterology and Hepatology","volume":" ","pages":"3304-3305"},"PeriodicalIF":3.5,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148880801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Methodological Considerations Regarding the Association Between Gastrointestinal Symptoms and Cognitive Decline in Parkinson's Disease.","authors":"Attiqa Khan, Mehnaz Ejaz Khokhar, Deepa Kumari, Peritee Dawani, Chandni Bai, Mah Noor Jamali","doi":"10.1111/jgh.70695","DOIUrl":"10.1111/jgh.70695","url":null,"abstract":"","PeriodicalId":15877,"journal":{"name":"Journal of Gastroenterology and Hepatology","volume":" ","pages":"3277-3278"},"PeriodicalIF":3.5,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148808810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to Letter to the Editor: Five-Year Survival Prognosis of Early-Onset and Later-Onset Colorectal Cancer by Clinical and Lifestyle Characteristics.","authors":"Jason J Liu","doi":"10.1111/jgh.70689","DOIUrl":"10.1111/jgh.70689","url":null,"abstract":"","PeriodicalId":15877,"journal":{"name":"Journal of Gastroenterology and Hepatology","volume":" ","pages":"3266-3267"},"PeriodicalIF":3.5,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148808769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Need for Mature Overall Survival Data Before Routine Adoption of TACE-Immunotherapy Combinations in HCC.","authors":"YaoYao Dai, Yeyun Lu, WenQiang Xie","doi":"10.1111/jgh.70663","DOIUrl":"10.1111/jgh.70663","url":null,"abstract":"","PeriodicalId":15877,"journal":{"name":"Journal of Gastroenterology and Hepatology","volume":" ","pages":"3236-3237"},"PeriodicalIF":3.5,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148764915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Accounting for Endoscopy Capacity When Linking Barrett's Esophagus Identification and Surveillance.","authors":"Yuqi He, Jianhong Zhang, Sheng Li","doi":"10.1111/jgh.70664","DOIUrl":"10.1111/jgh.70664","url":null,"abstract":"","PeriodicalId":15877,"journal":{"name":"Journal of Gastroenterology and Hepatology","volume":" ","pages":"3238-3239"},"PeriodicalIF":3.5,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148813161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}