Journal of Gastroenterology and Hepatology最新文献

{"title":"A Novel Clip Device for Safer and Faster Suturing in Endoscopic Papillectomy: A Retrospective Study of 241 Procedures","authors":"Kohei Takano,&nbsp;Kentaro Yamao,&nbsp;Takuya Ishikawa,&nbsp;Yoshihisa Takada,&nbsp;Yasuyuki Mizutani,&nbsp;Tadashi Iida,&nbsp;Kota Uetsuki,&nbsp;Takeshi Yamamura,&nbsp;Yoji Ishizu,&nbsp;Kazuhiro Furukawa,&nbsp;Takashi Honda,&nbsp;Masanao Nakamura,&nbsp;Hiroki Kawashima","doi":"10.1111/jgh.16963","DOIUrl":"https://doi.org/10.1111/jgh.16963","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background and Aim</h3>\u0000 \u0000 <p>Endoscopic papillectomy (EP) is a minimally invasive treatment for ampullary neoplasms. However, traditional endoscopic clips used for hemostasis and suturing during EP are often difficult to manipulate because of limitations in maneuverability. To address this issue, the efficacy of a novel clip was evaluated for its potential to improve suturing and reduce procedure difficulty after EP.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This retrospective study included 241 patients who underwent EP at Nagoya University Hospital between December 2004 and April 2024. Patients were divided into two groups: the conventional clip group (<i>n</i> = 184) and the novel clip group (<i>n</i> = 57). We compared the total clipping time, number of clips used, and incidence of adverse events between the two groups.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The total clipping time was significantly shorter in the novel clip group than in the conventional clip group (6.0 vs. 12.7 min, <i>p</i> &lt; 0.01). The novel clip group also required fewer clips for suturing (3.9 vs. 5.0 clips, <i>p</i> &lt; 0.01) and had fewer dislodged clips at the second look endoscopy (0.05 vs. 0.72 clips, <i>p</i> &lt; 0.01). There was no significant difference in the delayed bleeding rate between the two groups (5.3% vs. 8.7%, <i>p</i> = 0.58).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The novel clip demonstrated superior performance in terms of reducing the procedure time, the number of clips used, and the incidence of clip dislodgement in suturing after EP. This offers a promising solution for improving procedural efficiency. In conclusion, the novel clip should be used in wound suturing after EP.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15877,"journal":{"name":"Journal of Gastroenterology and Hepatology","volume":"40 5","pages":"1238-1244"},"PeriodicalIF":3.7,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143926107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond Identified Risk Factors: Exploring Diet, Microbial Dysbiosis, and Immune Crosstalk in Autoimmune Gastritis","authors":"Yadi Li,&nbsp;Xinmei Gao,&nbsp;Xinmin Deng","doi":"10.1111/jgh.16970","DOIUrl":"10.1111/jgh.16970","url":null,"abstract":"","PeriodicalId":15877,"journal":{"name":"Journal of Gastroenterology and Hepatology","volume":"40 6","pages":"1638-1639"},"PeriodicalIF":3.7,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144022359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to Editor: Comments on NLRP3 and Gut–Liver Axis: New Possibility for the Treatment of Alcohol-Associated Liver Disease","authors":"Muhammad Adnan,&nbsp;Khalil Ullah Khan,&nbsp;Sohaib Raza,&nbsp;Shah Rukh Rehman,&nbsp;Muzamil Ahmed","doi":"10.1111/jgh.16979","DOIUrl":"10.1111/jgh.16979","url":null,"abstract":"","PeriodicalId":15877,"journal":{"name":"Journal of Gastroenterology and Hepatology","volume":"40 6","pages":"1648-1649"},"PeriodicalIF":3.7,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144023210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PCED1A as a Predictive Biomarker for Immunotherapy and Anti-Angiogenic Treatment in Hepatocellular and Colorectal Cancer","authors":"Valbert Oliveira Costa Filho,&nbsp;Pedro Robson Costa Passos","doi":"10.1111/jgh.16969","DOIUrl":"10.1111/jgh.16969","url":null,"abstract":"","PeriodicalId":15877,"journal":{"name":"Journal of Gastroenterology and Hepatology","volume":"40 6","pages":"1635-1637"},"PeriodicalIF":3.7,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143983640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Depression or Anxiety in GI Outpatients: Upper GI Symptoms and Symptom Clusters Showed Stronger Associations Than Lower GI","authors":"Zhiyue Xu,&nbsp;Shengyan Zhang,&nbsp;Saier Li,&nbsp;Shu Xu,&nbsp;Dongke Wang,&nbsp;Siran Zhu,&nbsp;Xinghuang Liu,&nbsp;Jun Song,&nbsp;Jingsong Liu,&nbsp;Xiaohua Hou,&nbsp;Tao Bai,&nbsp;Likun Zhong","doi":"10.1111/jgh.16955","DOIUrl":"10.1111/jgh.16955","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background and Aim</h3>\u0000 \u0000 <p>Gastrointestinal (GI) problems have been always linked to psychiatric disorders. The aim of our study was to explore specific GI symptoms or symptom clusters that may indicate the presence of depression or anxiety in outpatients.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>One thousand one hundred twenty-five outpatients from 20 hospitals completed questionnaires assessing GI symptoms, depression (the Patient Health Questionnaire-9, PHQ-9), and anxiety (General Anxiety Disorder-7, GAD-7). Principal component analysis was employed to identify symptom clusters based on 22 GI symptoms. The patients were categorized into three groups: Control (PHQ-9 &lt; 5 and GAD-7 &lt; 5), DA1 (5 ≤ PHQ-9 &lt; 10 or/and 5 ≤ GAD-7 &lt; 10), and DA2 (PHQ-9 ≥ 10 or GAD-7 ≥ 10).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>There were 781, 249, and 95 patients in the group of Control, DA1, and DA2, respectively. Fecal incontinence (4.835, [2.213–10.563]), heartburn (3.338, [2.416–4.611]), belching (2.862, [2.145–3.821]), and globus sensation (2.845, [2.110–3.837]) demonstrated the highest potential risk of psychiatric comorbidity. The 22 GI symptoms were categorized into eight clusters. Dyspepsia-related Cluster F2, reflux-related Cluster F3, and esophageal-related Cluster F4 were noteworthy in the identification of psychiatric comorbidity. Cluster F4, including globus sensation, discomfort with swallowing, and chest pain, exhibited the most significant increase in the prevalence of depression or anxiety (2.645, [1.851–3.778]).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Specific GI symptoms including heartburn, belching, globus sensation, and GI symptom clusters including F2, F3, and F4 were noteworthy in the identification of psychiatric comorbidity. They were mostly focused on the upper GI tract. It is critical for gastroenterologists to recognize psychiatric comorbidities and implement appropriate measures accordingly.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15877,"journal":{"name":"Journal of Gastroenterology and Hepatology","volume":"40 6","pages":"1492-1499"},"PeriodicalIF":3.7,"publicationDate":"2025-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143795509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endoscopic Ultrasound–Guided Gastrojejunostomy as a Primary Treatment Modality for Malignant Gastric Outlet Obstruction: A Large Multicenter Experience","authors":"Nikhil Sonthalia,&nbsp;Radhika Chavan,&nbsp;Pankaj Singh,&nbsp;Jimmy Narayan,&nbsp;Sukrit Sud,&nbsp;Chirag N. Shah,&nbsp;Shankar Zanwar,&nbsp;Awanish Tewari,&nbsp;Sanjay Rajput,&nbsp;Vikas Singla,&nbsp;Akash Roy,&nbsp;Shanky Koul,&nbsp;Akash Goel,&nbsp;Uday C. Ghoshal,&nbsp;Mahesh Kumar Goenka","doi":"10.1111/jgh.16959","DOIUrl":"10.1111/jgh.16959","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>This work aims to describe technical feasibility and clinical outcomes of endoscopic-ultrasound-guided gastrojejunostomy (EUS-GJ) as a first line treatment option for malignant gastric outlet obstruction (mGOO).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This is a large multicenter study where patients undergoing EUS-GJ across seven tertiary care centers from India were analyzed. The primary outcomes were technical success defined as correct stent placement without any leak, and clinical success defined as improvement in gastric outlet obstruction symptom score (GOOSS) on follow-up. Secondary outcomes were (a) adverse events rates, (b) symptoms recurrence, (c) death on follow-up, and (d) resumption of chemotherapy.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of 71 patients underwent EUS-GJ with technical success of 94.3%. After successful stent placement, all patients tolerated oral liquid diet on day 1, whereas 89.5% and 95.5% tolerated oral solid diet on day 2 and day 7, respectively. Overall, 9/71(12.6%) patients had major adverse events, which included maldeployment in 6/71(8.4%). Mean duration of follow-up was 76.13 ± 58.09 days. On follow-up, reintervention was required in two (3%) patients. Around two-thirds of patients gained weight and could resume their chemotherapy post-EUS-GJ. Kaplan–Meier survival analysis showed that post EUS-GJ, mean overall survival (symptom recurrence or death) of 144.39 ± 11.53 days (95% CI 121.7–167.0).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>EUS-GJ is an excellent modality for the palliation of mGOO, providing high clinical success with extremely low rates of reintervention and acceptable safety profile. It should be considered as a primary modality for managing these patients, and enteral stent should be reserved for patients where EUS-GJ is not possible.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15877,"journal":{"name":"Journal of Gastroenterology and Hepatology","volume":"40 6","pages":"1515-1524"},"PeriodicalIF":3.7,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143780224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bifidobacterium Lactobacillus Triple Viable Alleviates Slow Transit Constipation by Regulating Gut Microbiota and Metabolism","authors":"Mei Luo,&nbsp;Peiwei Xie,&nbsp;Xuehong Deng,&nbsp;Jiahui Fan,&nbsp;Lishou Xiong","doi":"10.1111/jgh.16960","DOIUrl":"10.1111/jgh.16960","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Gut microbiota plays a crucial role in the pathogenesis and treatment of functional constipation (FC). The aim of this study was to explore the therapeutic effects of Bifidobacterium Lactobacillus triple viable on slow transit constipation (STC).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Patients with STC who met the Rome IV criteria received Bifidobacterium Lactobacillus triple viable. Gastrointestinal transit time (GITT) and constipation-related symptoms were assessed before and after receiving Bifidobacterium Lactobacillus triple viable. Additionally, a rat STC model was induced by loperamide and was treated with Bifidobacterium Lactobacillus triple viable to evaluate whether Bifidobacterium Lactobacillus triple viable could improve constipation in the rats and to explore the possible mechanisms involved.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>In patients with STC, Bifidobacterium Lactobacillus triple viable accelerated GITT and improved constipation-related symptoms, including bowel movement frequency, hard bowel movement, incomplete defecation, defecation time, purgative measures, and stool form. In addition, Bifidobacterium Lactobacillus triple viable improved body weight, food intake, bowel movement, the fecal water content, and the intestinal propulsion rate in STC rats. It regulates the gut microbiota structure in rats; increases serum acetylcholine (Ach), 5-hydroxytryptamine (5-HT), substance P (SP), and vasoactive intestinal peptide (VIP); increases fecal long-chain fatty acids (LCFAs); upregulates the mRNA expression of aquaporin 3 (AQP3) and aquaporin 3 (AQP8); and downregulates the mRNA expression of Toll-like receptor 2 (TLR2), Toll-like receptor 4 (TLR4), and interleukin-1β (IL-1β).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Bifidobacterium Lactobacillus triple viable ameliorated the GITT and constipation-related symptoms of patients with STC and improved the STC in rats by regulating the gut microbiota and metabolism.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15877,"journal":{"name":"Journal of Gastroenterology and Hepatology","volume":"40 6","pages":"1561-1573"},"PeriodicalIF":3.7,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jgh.16960","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143780222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Visibility and Performance of Small Bowel Video Capsule Endoscopy With and Without Pre-Procedural Purge Preparation in the Same Patients","authors":"Reuma Margalit Yehuda,&nbsp;Yana Davidov,&nbsp;Limor Selinger,&nbsp;Bella Ungar,&nbsp;Adi Lahat,&nbsp;Doron Yablecovitch,&nbsp;Sandra Neuman,&nbsp;Uri Kopylov,&nbsp;Shomron Ben Horin,&nbsp;Rami Eliakim,&nbsp;For the Israeli IBD Research Nucleus (IIRN)","doi":"10.1111/jgh.16954","DOIUrl":"10.1111/jgh.16954","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Small bowel (SB) video capsule endoscopy (VCE) is an established diagnostic tool for the investigation of SB pathologies. Despite clinical studies and a few meta-analyses, an area of continuing controversy is the role of pre-procedural bowel preparation.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>We compared the visibility and performance of VCE with and without purge preparation in the same patients.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Design</h3>\u0000 \u0000 <p>Post hoc analysis of randomized control trial.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This is a post hoc analysis of the prospective randomized CURE-CD Trial (Comprehensive individUalized pRoactive ThErapy of Crohn's Disease trial). Established Crohn's disease (CD) patients in clinical remission were enrolled and classified into two groups according to relapse risk assessment. All patients are followed up in our clinic and undergo laboratory tests every 3 months and serial VCE studies every 6 months. The first VCE is done after bowel preparation with a clear liquid diet, PEG, and laxative, whereas the subsequent VCEs, when disease is confined to SB only, are done after a day on clear liquid diet. The VCE visibility is rated (1–4 points) by a blind observer, unaware to the preparation regimen.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Forty patients who underwent at least two VCEs, at baseline and after 6 months were included. Visibility scores were similar in these two time points (3.15 vs. 3.10, <i>p</i> = 0.8). Among the low-risk patients' group (<i>n</i> = 16) in whom the clinical parameters (CDAI, CRP, and fecal calprotectin) have not changed significantly during this period, Inflammatory scores assessed by the capsule Lewis score (LS) and PillCam-CD score (PCDS) were similar (median LS 225 vs. 225, <i>p</i> = 0.87, median PCDS 4 vs. 2, <i>p</i> = 0.37).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The visibility and performance of SB VCE for monitoring Crohn's disease is not significantly influenced by purge preparation.</p>\u0000 \u0000 <p><b>Trial Registration:</b> Clinicatrials.gov identifier: NCT03555058.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15877,"journal":{"name":"Journal of Gastroenterology and Hepatology","volume":"40 6","pages":"1485-1491"},"PeriodicalIF":3.7,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/jgh.16954","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143772708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Irisin Alleviates Impaired Mitochondrial Fusion via Enhancing PKA/SIRT3/mTOR Pathway in Hepatic Steatosis","authors":"Jia Li,&nbsp;Ying Zhao,&nbsp;Zhihong Wang,&nbsp;Anran Ma,&nbsp;Yunzhi Ni,&nbsp;Di Wu,&nbsp;Yue Zhou,&nbsp;Na Zhang,&nbsp;Li Zhang,&nbsp;Yongsheng Chang,&nbsp;Qinghua Wang","doi":"10.1111/jgh.16950","DOIUrl":"10.1111/jgh.16950","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background and Aim</h3>\u0000 \u0000 <p>Hepatic steatosis, a hallmark of metabolic dysfunction–associated steatotic liver disease (MASLD), arises from disrupted lipid homeostasis. Mitochondrial dysfunction, particularly imbalances in mitochondrial fusion and fission, plays a crucial role in MASLD progression. Irisin, an exercise-induced myokine, is involved in lipid metabolism, though its precise mechanisms of action remain unclear.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>An irisin-Fc fusion protein was prophylactically administered to mice with high-fat diet (HFD)–induced MASLD for 12 weeks. Liver tissues were analyzed using oil red O staining and hepatic and serum lipid profiling to evaluate irisin's therapeutic efficacy. Expression levels of proteins involved in fatty acid metabolism and mitochondrial dynamics were assessed. In palmitate (PA)-treated HepG2 cells, mitochondrial morphology was analyzed, and fatty acid uptake was determined through colocalization of fluorescently labeled PA with mitochondria. PKA activity and SIRT3 expression were validated using a PKA agonist/inhibitor and SIRT3 overexpression or knockdown via plasmid transfection and siRNA.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Irisin significantly reduced lipid accumulation in HFD-induced MASLD mouse models and PA-treated HepG2 cells. These effects were associated with enhanced mitochondrial fusion, indicated by increased expression of mitofusin 2 and optic atrophy type 1 and reduced excessive fission, evidenced by decreased activation of dynamin-related protein 1. These changes were mediated partly through PKA/SIRT3/mTOR pathway activation, which facilitated mitochondrial fatty acid uptake and β-oxidation while inhibiting lipogenesis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Our results demonstrate the protective role of irisin in alleviating hepatic steatosis by regulating mitochondrial dynamics. These findings provide valuable evidence of the antisteatogenic mechanisms of irisin and its therapeutic potential for MASLD management.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15877,"journal":{"name":"Journal of Gastroenterology and Hepatology","volume":"40 6","pages":"1616-1630"},"PeriodicalIF":3.7,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143764190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiology and Impact of Disorders of Gut–Brain Interaction in Multiethnic Malaysia: An In-Depth Analysis of Local Data From the Rome Foundation Global Epidemiology Study","authors":"Daniel Martin Simadibrata,&nbsp;Elvira Lesmana,&nbsp;Thai Hau Koo,&nbsp;Hematram Yadav,&nbsp;Kuck Meng Chong,&nbsp;Kamarul Imran Musa,&nbsp;Kueh Yee Cheng,&nbsp;Nashrullhaq Tagiling,&nbsp;NorFilza M. Mokhtar,&nbsp;NurHazwani Abdul Hamid,&nbsp;Nurzulaikha Abdullah,&nbsp;Mohd Helmy Mokhtar,&nbsp;Norhazlina Abdul Wahab,&nbsp;Pojsakorn Danpanichkul,&nbsp;Yung Yang Chong,&nbsp;Zhiqin Wong,&nbsp;Ami Sperber,&nbsp;Shrikant I. Bangdiwala,&nbsp;Olafur S. Palsson,&nbsp;Yeong Yeh Lee","doi":"10.1111/jgh.16953","DOIUrl":"10.1111/jgh.16953","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Previous epidemiology studies from Malaysia on disorders of gut–brain interaction (DGBI) have utilized variable criteria. Furthermore, the impact of DGBI on quality of life (QoL), healthcare utilization, diet, work productivity, and sleep in a multiethnic Asian setting like Malaysia remains underexplored. Here, we aimed to determine the epidemiology and impact of DGBI among multiethnic Malaysians based on the Rome IV criteria.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>2072 Malaysian participants from the Rome Foundation Global Epidemiology Study (RFGES) with complete data on DGBI were included in the in-depth analysis. We assessed the prevalence of DGBI diagnoses, psychological distress, QoL, healthcare utilization, dietary patterns, impact on sleep, work productivity, and activity impairment.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The overall prevalence of any DGBI in Malaysia was 19.3% (95% CI 17.6%–21.0%). The top three most prevalent DGBI diagnoses were functional constipation (5.1%; 95% CI 4.2%–6.1%), functional dyspepsia (3.4%; 95% CI 2.7%–4.3%), and functional diarrhea (1.6%; 95% CI 1.1%–2.2%). Participants with DGBI reported higher levels of psychological distress (somatization, anxiety, and depression), significantly higher healthcare utilization, and dietary change (low FODMAPs but higher Mediterranean-based diet and probiotics). Furthermore, there was greater daytime sleepiness and higher proportions of presenteeism, overall work impairment, and activity impairment in individuals with DGBI.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The disease burden of DGBI is significant in Malaysia, with increased psychological distress, healthcare utilization, dietary change, greater daytime sleepiness, and greater overall work and activity impairment.</p>\u0000 </section>\u0000 </div>","PeriodicalId":15877,"journal":{"name":"Journal of Gastroenterology and Hepatology","volume":"40 6","pages":"1472-1484"},"PeriodicalIF":3.7,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143764188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}