Journal of Evidence-based Integrative Medicine最新文献

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Objective Evaluation of Pulse Width Using an Array Pulse Diagram. 使用阵列脉冲图客观评估脉冲宽度。
IF 3.5
Journal of Evidence-based Integrative Medicine Pub Date : 2024-01-01 DOI: 10.1177/2515690X241241859
Zi-Juan Bi, Ji Cui, Xing-Hua Yao, Xiao-Juan Hu, Si-Han Wang, Meng-Chen Liang, Zhi-Hui Zhou, Jia-Tuo Xu
{"title":"Objective Evaluation of Pulse Width Using an Array Pulse Diagram.","authors":"Zi-Juan Bi, Ji Cui, Xing-Hua Yao, Xiao-Juan Hu, Si-Han Wang, Meng-Chen Liang, Zhi-Hui Zhou, Jia-Tuo Xu","doi":"10.1177/2515690X241241859","DOIUrl":"10.1177/2515690X241241859","url":null,"abstract":"<p><strong>Background: </strong>Pulse width, which can reflect <i>qi</i>, <i>blood</i> excess, and deficiency, has been used for diagnosing diseases and determining the prognosis in traditional Chinese medicine (TCM). This study aimed to devise an objective method to measure the pulse width based on an array pulse diagram for objective diagnosis.</p><p><strong>Methods: </strong>The channel 6, the region wherein the pulse wave signal is the strongest, is located in the middle of the pulse sensor array and at the <i>guan</i> position of <i>cunkou</i> during data collection. Therefore, the main wave (h<sub>1</sub>) time of the pulse wave was collected from the channel 6 through calculation. The left h<sub>1</sub> time was collected from the remaining 11 channels. The amplitudes at these time points were extracted as the h<sub>1</sub> amplitudes for each channel. However, the pulse width could not be calculated accurately at 12 points. Consequently, a bioharmonic spline interpolation algorithm was used to interpolate the h<sub>1</sub> amplitude data obtained from the horizontal and vertical points, yielding 651 (31 × 21) h<sub>1</sub> amplitude data. The 651 data points were converted into a heat map to intuitively calculate the pulse width. The pulse width was calculated by multiplying the number of grids on the vertical axis with the unit length of the grid. The pulse width was determined by TCM doctors to verify the pulse width measurement accuracy. Meanwhile, a color Doppler ultrasound examination of the volunteers' radial arteries was performed and the intravascular meridian widths of the radial artery compared with the calculated pulse widths to determine the reliability.</p><p><strong>Results: </strong>The pulse width determined using the maximal h<sub>1</sub> amplitude method was comparable with the radial artery intravascular meridian widths measured using color Doppler ultrasound. The h<sub>1</sub> amplitude was higher in the high blood pressure group and the pulse width was greater.</p><p><strong>Conclusions: </strong>The pulse width determined using the maximal h<sub>1</sub> amplitude was objective and accurate. Comparison between the pulse widths of the normal and high blood pressure groups verified the reliability of the method.</p>","PeriodicalId":15714,"journal":{"name":"Journal of Evidence-based Integrative Medicine","volume":"29 ","pages":"2515690X241241859"},"PeriodicalIF":3.5,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11119526/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140305821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Phytolacca Dodecandra (L' Herit) (Phytolaccaceae) Methanol Root Extract Protects Liver from Acetaminophen-Induced Injury in Rats. Phytolacca Dodecandra (L' Herit)(Phytolaccaceae)甲醇根提取物可保护大鼠肝脏免受对乙酰氨基酚引起的损伤。
IF 3.3
Journal of Evidence-based Integrative Medicine Pub Date : 2024-01-01 DOI: 10.1177/2515690X241263063
Gudeta Duga Geresu, Tilahun Tesfaye Abebe, Diriba Alemayehu Gadisa, Getu Melese Taye, Dejene Hailu Bedada, Tamirat Bekele Baressa, Shemsu Umer Hussen, Tesemma Sileshi Chala
{"title":"<i>Phytolacca Dodecandra</i> (L' Herit) (Phytolaccaceae) Methanol Root Extract Protects Liver from Acetaminophen-Induced Injury in Rats.","authors":"Gudeta Duga Geresu, Tilahun Tesfaye Abebe, Diriba Alemayehu Gadisa, Getu Melese Taye, Dejene Hailu Bedada, Tamirat Bekele Baressa, Shemsu Umer Hussen, Tesemma Sileshi Chala","doi":"10.1177/2515690X241263063","DOIUrl":"10.1177/2515690X241263063","url":null,"abstract":"<p><p><i>Phytolacca dodecandra</i> (L' Herit), or 'Endod', is one of the widely known medicinal plants in Ethiopia. Berries of the endod have been used as a detergent for centuries. The present study was aimed to test the hepatoprotective effects of the plant against acetaminophen (APAP)-induced liver injury in rats. Mice of either sex were used for oral acute toxicity tests and APAP-induced lethality tests. Hepatoprotective experiments were done on male rats using 2 g/kg of APAP to induce liver damage. Liver enzymes, total bilirubin (TB), and lipid profile were determined. Liver tissues were also examined histopathologically to see a morphologic change in the control and experiment groups. The protective effect of the plant extract was also tested through sodium pentobarbital (SPB)-induced sleeping time. A significant increase in serum levels of liver enzymes, TB, low-density lipoprotein (LDL), and triglycerides (TGs) was seen from oral administration of 2 g/kg APAP. Total cholesterol (TC) and high-density lipoprotein (HDL) levels were decreased. Serum levels of all parameters were reversed to normal after administration of silymarin 100 mg/kg and, 100, 200, and 400 mg/kg doses of the extract. A significant dose-dependent hepatoprotective effect of <i>Phytolacca dodecandra</i> Methanol Root Extract (PDME) was seen in terms of LDL. Histopathological investigations and SPB-induced sleeping time confirmed the findings of biochemical analysis. The findings of the present study indicate that PDME protected the liver from APAP injury.</p>","PeriodicalId":15714,"journal":{"name":"Journal of Evidence-based Integrative Medicine","volume":"29 ","pages":"2515690X241263063"},"PeriodicalIF":3.3,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11273601/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141759078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Melanogenesis Inhibitory Activity, Chemical Components and Molecular Docking Studies of Prunus cerasoides Buch.-Ham. D. Don. Flowers. 桃李黑素生成抑制活性、化学成分及分子对接研究。d .堂。花。
IF 3.5
Journal of Evidence-based Integrative Medicine Pub Date : 2023-01-01 DOI: 10.1177/2515690X231152928
Nateelak Kooltheat, Aman Tedasen, Kenshi Yamasaki, Moragot Chatatikun
{"title":"Melanogenesis Inhibitory Activity, Chemical Components and Molecular Docking Studies of <i>Prunus cerasoides</i> Buch.-Ham. D. Don. Flowers.","authors":"Nateelak Kooltheat,&nbsp;Aman Tedasen,&nbsp;Kenshi Yamasaki,&nbsp;Moragot Chatatikun","doi":"10.1177/2515690X231152928","DOIUrl":"https://doi.org/10.1177/2515690X231152928","url":null,"abstract":"<p><p>Safe depigmenting agents are currently increasing in the cosmetic or pharmaceutical industry because various compounds have been found to have undesirable side effects. Therefore, the present study aimed to investigate the melanogenesis inhibitory effects of <i>Prunus cerasoides</i> Buch. -Ham. D. Don. flower extracts and their molecular mechanism in B16F10 mouse melanoma cells. Moreover, we also examined phenolic and flavonoid contents, antioxidant activity, chemical constituents of potential extracts, and molecular docking. The highest phenolic and flavonoid contents with the greatest scavenging activity were found in the butanol extract of the <i>P. cerasoides</i> flower compared to other extracts. From all extracts, only crude, diethyl ether, and butanol extracts showed an inhibition of mushroom tyrosinase activity, cellular tyrosinase activity, and melanin content as well as the downregulation of the gene expression of the microphthalmia-associated transcription factor (MITF), tyrosinase, tyrosinase-related protein-1 (TRP-1), and tyrosinase-related protein-2 (TRP-2) in α-MSH-stimulated B16F10 cells. Based on the molecular docking study, n-hexadecanoic acid, heptadecanoic acid, octadecanoic acid, 9,12-octadecadienoic acid, 9,12,15-octadecanoic acid, and eicosanoic acid might show an inhibitory effect against tyrosinase and MITF. In conclusion, this finding demonstrates that both the diethyl ether and butanol extracts of the <i>P. cerasoides</i> flower can effectively reduce tyrosinase activity and melanin synthesis through the downregulation of the melanogenic gene expression in B16F10 cells and through the molecular docking study. Taken together, the diethyl ether and butanol extracts of the <i>P. cerasoides</i> flower could be an anti-melanogenic ingredient for hyperpigmentary or melasma treatment.</p>","PeriodicalId":15714,"journal":{"name":"Journal of Evidence-based Integrative Medicine","volume":"28 ","pages":"2515690X231152928"},"PeriodicalIF":3.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/45/35/10.1177_2515690X231152928.PMC9905211.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9237947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of Antimalarial Activity of Ethanolic Extract of Annona muricata L.: An in vivo and an in silico Approach. 番荔枝醇提物抗疟活性的体内和体外研究。
IF 3.5
Journal of Evidence-based Integrative Medicine Pub Date : 2023-01-01 DOI: 10.1177/2515690X231165104
Charles Obiora Nwonuma, Elizabeth Abiodun Balogun, Gideon Ampoma Gyebi
{"title":"Evaluation of Antimalarial Activity of Ethanolic Extract of <i>Annona muricata L</i>.: An <i>in vivo</i> and an <i>in silico</i> Approach.","authors":"Charles Obiora Nwonuma,&nbsp;Elizabeth Abiodun Balogun,&nbsp;Gideon Ampoma Gyebi","doi":"10.1177/2515690X231165104","DOIUrl":"https://doi.org/10.1177/2515690X231165104","url":null,"abstract":"<p><p>In Nigeria, <i>Annona muricata</i> L. has been used to treat a variety of ailments. The mechanism of the antimalarial activity of ethanolic leaf extract of <i>Annona muricata</i> (EEAML) was investigated using both an in vivo and an in silico approach. The experimental mice were divided into five groups: A-F. The mice in groups B-F were inoculated with <i>Plasmodium berghei</i> NK-65 and treated accordingly. Groups A and B are the negative and positive controls (infected and untreated), respectively. Group C received 10 mg/kg chloroquine (standard drug), whereas groups D-F received 100, 200, and 300 mg/kg body weight of the extract orally respectively. The mice were euthanized eight days after infection, and their liver and blood were collected and used in biochemical tests. Molecular docking was performed using the extract's HPLC compounds and <i>Plasmodium falciparum</i> proteins. In the suppressive, prophylactic, and curative tests, there was a significant decrease (p < 0.05) in parasitemia levels in groups treated with the extract compared to the positive control and standard drug. When compared to the positive control, there was a significant (p < 0.05) reduction in liver MDA, total cholesterol, and total triglyceride levels. The binding energies of luteolin and apigenin-<i>pf</i>protein complexes were significantly (p < 0.05) higher compared to their respective references. The anti-plasmodial activity of the extract may result from its hypolipidemic effect, which deprives the parasite of essential lipid molecules needed for parasite growth, as well as from the inhibitory effects of apigenin and luteolin on specific proteins required for the <i>Plasmodium</i> metabolic pathway.</p>","PeriodicalId":15714,"journal":{"name":"Journal of Evidence-based Integrative Medicine","volume":"28 ","pages":"2515690X231165104"},"PeriodicalIF":3.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/25/56/10.1177_2515690X231165104.PMC10084581.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9997074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Antiproliferative and Anti-Inflammatory Activities of Deprungsith Formulation and Its Bioactive Compounds Against Mild Psoriasis and Potential of Metabolic Herb-Drug Interactions. Deprungsith制剂及其生物活性化合物对轻度银屑病的抗增殖和抗炎活性以及代谢药物相互作用的潜力。
IF 3.5
Journal of Evidence-based Integrative Medicine Pub Date : 2023-01-01 DOI: 10.1177/2515690X231191101
Kesara Na-Bangchang, Monthaka Teerachaisakul, Phunuch Muhamad, Yositha Kasemnitichok, Nattida Sangnarong, Kanyarat Boonprasert, Mayuri Tarasuk, Tullayakorn Plengsuriyakarn
{"title":"Antiproliferative and Anti-Inflammatory Activities of Deprungsith Formulation and Its Bioactive Compounds Against Mild Psoriasis and Potential of Metabolic Herb-Drug Interactions.","authors":"Kesara Na-Bangchang, Monthaka Teerachaisakul, Phunuch Muhamad, Yositha Kasemnitichok, Nattida Sangnarong, Kanyarat Boonprasert, Mayuri Tarasuk, Tullayakorn Plengsuriyakarn","doi":"10.1177/2515690X231191101","DOIUrl":"10.1177/2515690X231191101","url":null,"abstract":"<p><p>Psoriasis is an incurable, chronic and auto-immune skin disorder with a global prevalence rate of approximately 2-3%. The study investigated the antipsoriasis activities of Deprungsith formulation and its bioactive components and their potential for inhibitory activities on human cytochrome P450 (CYP450). HaCaT and peripheral blood mononuclear cells (PBMCs) from healthy volunteers (n = 9) and psoriasis patients (n = 10) were exposed to Deprungsith formulation (Thai traditional medicine for psoriasis consisting of 16 plants), ethyl p-methoxycinnamate (EPMC), ligustilide and cyclosporin for 24 and 48 h. The antiproliferative, cell apoptosis and cell cycle arrest activities were evaluated using MTT assay and flow cytometry, respectively. The pro-inflammatory cytokine mRNA expression levels were measured using real-time polymerase chain reaction (RT-PCR). The CYP450 inhibitory effect was investigated using a bioluminescent-based CYP450 assay. Deprungsith formulation and the bioactive compounds inhibited HaCaT cells and PBMCs with weak to moderate potencies. EPMC and ligustilide combination produced an additive effect. Most substances arrested cell transition at sub-G<sub>1</sub> and S phases, leading to early and late apoptosis induction. With prolonged exposure (48 h), all test substances decreased PBMCs necrosis. The mRNA expression of all pro-inflammatory cytokines was downregulated. Deprungsith formulation, EPMC, ligustilide and ferulic acid inhibited CYP1A2, CYP2C9, CYP2D6 and CYP3A4 activities with weak to moderate potencies. Deprungsith formulation and bioactive components induced cell apoptosis by inhibiting cell transition at specific cell cycle phases, which was correlated with the mRNA downregulation of interleukin (IL-6, IL-12p19, IL-23) and tumor necrosis factor (TNF-α). There is a low risk of potential adverse drug reactions and toxicity due to CYP450 interaction when Deprungsith formulation is concurrently administered with modern medicines.</p>","PeriodicalId":15714,"journal":{"name":"Journal of Evidence-based Integrative Medicine","volume":"28 ","pages":"2515690X231191101"},"PeriodicalIF":3.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/6f/37/10.1177_2515690X231191101.PMC10413907.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10032030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cananga odorata Aromatherapy Reduces Anxiety in Unexperienced Patients Hospitalized for Interventional Neuroradiology Procedures: A Randomized Control Trial. 芳香疗法可减少因介入神经放射学手术住院的无经验患者的焦虑:一项随机对照试验。
IF 3.5
Journal of Evidence-based Integrative Medicine Pub Date : 2023-01-01 DOI: 10.1177/2515690X221150527
Jetsada Sriboonlert, Waranon Munkong, Sunantha Rintawut, Soodjai Paladkhua, Ratchalita Suwongsa, Woranan Kirisattayakul
{"title":"<i>Cananga odorata</i> Aromatherapy Reduces Anxiety in Unexperienced Patients Hospitalized for Interventional Neuroradiology Procedures: A Randomized Control Trial.","authors":"Jetsada Sriboonlert,&nbsp;Waranon Munkong,&nbsp;Sunantha Rintawut,&nbsp;Soodjai Paladkhua,&nbsp;Ratchalita Suwongsa,&nbsp;Woranan Kirisattayakul","doi":"10.1177/2515690X221150527","DOIUrl":"https://doi.org/10.1177/2515690X221150527","url":null,"abstract":"<p><p>The hospitalization and the unfamiliar experiences of patients in interventional radiology procedures cause a moderate to high levels of anxiety. This study was aimed to evaluate the anxiolytic effect of <i>Cananga odorata</i> essential oil (COE) aromatherapy in unexperienced patients hospitalized for interventional neuroradiology (INR) procedures. Forty-four patients admitted for their first INR procedure were randomly divided into COE and placebo control groups. COE or distilled water was dropped onto 2 pieces of mulberry paper and attached to the participant's gown at the shoulder level overnight. The main outcomes were observed from the morning salivary cortisol levels and salivary alpha-amylase activity after intervention. The Thai version of Spielberger State-Trait Anxiety Inventory (STAI) and the vital signs (blood pressure and heart rate) were also assessed before and after COE intervention as the secondary outcome. The demographic and baseline data of both groups did not show any significant difference. After intervention, COE group had a significantly lower salivary alpha-amylase activity than placebo control group. The post-intervention scores of Trait (STAI-T) and State (STAI-S) anxiety were significantly less than those of baseline in both groups. Interestingly, the COE group had a greater percentage reduction on STAI-T after intervention than placebo control group. No significant difference was observed in other outcomes. In addition, the salivary alpha-amylase activity was weak but showed significant correlation with STAI anxiety scores. This study indicates that COE aromatherapy reduces the saliva alpha amylase activity and STAI-T anxiety in unexperienced patients hospitalized for INR procedures.</p>","PeriodicalId":15714,"journal":{"name":"Journal of Evidence-based Integrative Medicine","volume":"28 ","pages":"2515690X221150527"},"PeriodicalIF":3.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/19/57/10.1177_2515690X221150527.PMC9871980.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9243252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cardioprotective Effects of Vitex negundo: A Review of Bioactive Extracts and Compounds. 黄荆的心脏保护作用:生物活性提取物和化合物的研究进展。
IF 3.5
Journal of Evidence-based Integrative Medicine Pub Date : 2023-01-01 DOI: 10.1177/2515690X231176622
Boniface Nyamweya, Dilani Rukshala, Narmada Fernando, Rajiva de Silva, Sunil Premawansa, Shiroma Handunnetti
{"title":"Cardioprotective Effects of <i>Vitex negundo</i>: A Review of Bioactive Extracts and Compounds.","authors":"Boniface Nyamweya,&nbsp;Dilani Rukshala,&nbsp;Narmada Fernando,&nbsp;Rajiva de Silva,&nbsp;Sunil Premawansa,&nbsp;Shiroma Handunnetti","doi":"10.1177/2515690X231176622","DOIUrl":"https://doi.org/10.1177/2515690X231176622","url":null,"abstract":"<p><p>There has been accumulating interest in the application of medicinal plants as alternative medicine to treat various diseases and/or to develop modern medicines. <i>Vitex negundo</i> is one of such medicinal plants that has been of interest to many researchers and has been of use in traditional medicine<i>. V. negundo</i> is found in Sri Lanka, Madagascar, Malaysia, India, China, The Philippines and East Africa. Therapeutic properties of <i>V. negundo</i> have previously been reviewed. Different parts, preparations and bioactive components of <i>V. negundo</i> possess potential protective and therapeutic effects against cardiovascular disease and related conditions as demonstrated in previous studies. We review the present state of scientific knowledge on the potential use of <i>V. negundo</i> and some of its bioactive components in protecting against cardiovascular diseases and related pathologies. Previous studies in animal and non-animal experimental models, although limited in number and vary in design, seem to support the cardioprotective effect of <i>V. negundo</i> and some of its active components. However, there is need for further preclinical and clinical studies to validate the use of <i>V. negundo</i> and its active constituents in protection and treatment of cardiovascular diseases. Additionally, since only a few <i>V. negundo</i> compounds have been evaluated, specific cardioprotective effects or mechanisms and possible side effects of other <i>V. negundo</i> compounds need to be extensively evaluated.</p>","PeriodicalId":15714,"journal":{"name":"Journal of Evidence-based Integrative Medicine","volume":"28 ","pages":"2515690X231176622"},"PeriodicalIF":3.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/ef/e6/10.1177_2515690X231176622.PMC10259128.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9623663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cassava (Manihot esculenta Crantz): A Systematic Review for the Pharmacological Activities, Traditional Uses, Nutritional Values, and Phytochemistry. 木薯:药理活性、传统用途、营养价值和植物化学的系统综述。
IF 3.5
Journal of Evidence-based Integrative Medicine Pub Date : 2023-01-01 DOI: 10.1177/2515690X231206227
Siti Raudhah Noor Shifa Putri Mohidin, Said Moshawih, Andi Hermansyah, Mohd Ikmal Asmuni, Naeem Shafqat, Long Chiau Ming
{"title":"Cassava (<i>Manihot esculenta</i> Crantz): A Systematic Review for the Pharmacological Activities, Traditional Uses, Nutritional Values, and Phytochemistry.","authors":"Siti Raudhah Noor Shifa Putri Mohidin, Said Moshawih, Andi Hermansyah, Mohd Ikmal Asmuni, Naeem Shafqat, Long Chiau Ming","doi":"10.1177/2515690X231206227","DOIUrl":"10.1177/2515690X231206227","url":null,"abstract":"<p><p>Cassava (<i>Manihot esculenta</i> Crantz) is considered one of the essential tuber crops, serving as a dietary staple food for various populations. This systematic review provides a comprehensive summary of the nutritional and therapeutic properties of cassava, which is an important dietary staple and traditional medicine. The review aims to evaluate and summarize the phytochemical components of cassava and their association with pharmacological activities, traditional uses, and nutritional importance in global food crises. To collect all relevant information, electronic databases; Cochrane Library, PubMed, Scopus, Web of Science, Google Scholar, and Preprint Platforms were searched for studies on cassava from inception until October 2022. A total of 1582 studies were screened, while only 34 were included in this review. The results of the review indicate that cassava has diverse pharmacological activities, including anti-bacterial, anti-cancer, anti-diabetic, anti-diarrheal, anti-inflammatory, hypocholesterolemic effects, and wound healing properties. However, more studies that aim to isolate the phytochemicals in cassava extracts and evaluate their pharmacological property are necessary to further validate their medical and nutritional values.</p>","PeriodicalId":15714,"journal":{"name":"Journal of Evidence-based Integrative Medicine","volume":"28 ","pages":"2515690X231206227"},"PeriodicalIF":3.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/7e/eb/10.1177_2515690X231206227.PMC10571719.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41202876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Short-Term Safety Evaluation of Silbinol®- an Extract from Pterocarpus marsupium in Healthy Adults- a Randomized, Double-Blind, Placebo-Controlled Study. Silbinol®——一种从有袋翼龙中提取的提取物——在健康成年人中的短期安全性评估——一项随机、双盲、安慰剂对照研究。
IF 3.5
Journal of Evidence-based Integrative Medicine Pub Date : 2023-01-01 DOI: 10.1177/2515690X231198312
Muhammed Majeed, Kalyanam Nagabhushanam, Shaji Paulose, Lakshmi Mundkur
{"title":"A Short-Term Safety Evaluation of Silbinol<sup>®</sup>- an Extract from <i>Pterocarpus marsupium</i> in Healthy Adults- a Randomized, Double-Blind, Placebo-Controlled Study.","authors":"Muhammed Majeed, Kalyanam Nagabhushanam, Shaji Paulose, Lakshmi Mundkur","doi":"10.1177/2515690X231198312","DOIUrl":"10.1177/2515690X231198312","url":null,"abstract":"<p><p><b>Background:</b> <i>Ptero</i>stilbene is an active molecule from the bark of the <i>Pterocarpus marsupium</i> tree with antioxidant and anti-inflammatory properties. <b>Objective:</b> This study aimed to evaluate the clinical safety of a standardized <i>P. marsupium</i> extract (PME) containing 90% pterostilbene (200 mg per day) in healthy adults. <b>Methods:</b> In a randomized, double-blind, placebo-controlled study, 60 healthy adult participants (27 males and 33 females) were randomized to receive PME-100 mg or placebo capsule twice a day for two months. The primary objectives of the study were to assess any changes in laboratory parameters, vital signs, and the occurrence of adverse events from screening to the final visit. Serum antioxidant enzyme levels were evaluated as a secondary outcome. <b>Results:</b> The hematological, lipid, glycemic, thyroid profiles and liver and renal functions remained within the normal range in all participants, with no difference between PME and placebo. Vital signs, including blood pressure, pulse rate, body weight, body mass index and electrocardiogram, did not reveal any significant differences between the PME and placebo groups at the beginning and end of the study. No serious adverse events were observed in any participant throughout the study period. The serum antioxidant profile was not significantly different between the treatment groups, although the glutathione levels were relatively higher in the PME group. <b>Conclusions:</b> Scientific evaluation of clinical safety of standardized extract is mandatory for its use as a supplement for various health benefits. The results of this study convincingly establish the safety of PME (>90% Pterostilbene) at 200 mg/day (100 mg bid) for human use. The study was approved by the Institutional Ethics Committee of BGS Global Institute of Medical Sciences & Hospital, Bangalore with the registration number CTRI/2019/08/020736.</p>","PeriodicalId":15714,"journal":{"name":"Journal of Evidence-based Integrative Medicine","volume":"28 ","pages":"2515690X231198312"},"PeriodicalIF":3.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/75/98/10.1177_2515690X231198312.PMC10483972.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10189316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparing Vitamin D Level Between Patients with Psoriasis and Healthy Individuals: A Systematic Review and Meta-Analysis. 银屑病患者和健康人维生素D水平的比较:系统综述和荟萃分析。
IF 3.5
Journal of Evidence-based Integrative Medicine Pub Date : 2023-01-01 DOI: 10.1177/2515690X231211663
Mahmood Moosazadeh, Giovanni Damiani, Mohammad Khademloo, Motahareh Kheradmand, Fatemeh Nabinezhad-Male, Amirhossein Hessami
{"title":"Comparing Vitamin D Level Between Patients with Psoriasis and Healthy Individuals: A Systematic Review and Meta-Analysis.","authors":"Mahmood Moosazadeh, Giovanni Damiani, Mohammad Khademloo, Motahareh Kheradmand, Fatemeh Nabinezhad-Male, Amirhossein Hessami","doi":"10.1177/2515690X231211663","DOIUrl":"10.1177/2515690X231211663","url":null,"abstract":"<p><strong>Background: </strong>Psoriasis is nowadays regarded as a systemic inflammatory disorder. Among the topicals, vitamin D derivates are often applied on the skin for their anti-inflammatory and immune-modulatory properties. Vitamin D serum levels in psoriasis (PsO) patients are still debated and an eventual depletion may offer the rational to integrate anti-psoriatic therapies with oral vitamin D. Then, we aimed to perform a systematic review and meta-analysis on the current evidence towards serum vitamin D level in PsO.</p><p><strong>Methods: </strong>We searched in PubMed, Scopus, Web of Sciences, ScienceDirect and Science Information Database (SID) using the terms \"Vitamin D\" and \"Psoriasis\" including manuscripts in English, Italian and Persian. Duplications were excluded using EndNote software and records were screened by title, abstract and full-text. Quality assessment of studies was assessed using Newcastle Ottawa Checklist (NOS). Psoriasis odds ratio (OR) and mean serum vitamin D levels were calculated and displayed in Forest-plots. Heterogeneity indexes were evaluated using <i>I</i><sup>2</sup> and Q. Sensitivity analysis and publication biases were also considered.</p><p><strong>Results: </strong>From 3006 records extracted, after removing duplicates and analyzing full texts we finally included 19 manuscripts involving a total of 1387 PsO cases and 6939 controls. PsO patients exhibited a substantial odds ratio (3.07, 95% CI: 1.56-6.04) for lower serum vitamin D levels compared to the control group. Standardized Mean Difference (SMD) of vitamin D in PsO versus controls was -0.92 (-1.33 to -0.51).</p><p><strong>Conclusion: </strong>Psoriatic patients displayed higher risk to have a vitamin D deficiency. Interventional studies to verify the preventive value are mandatory.</p>","PeriodicalId":15714,"journal":{"name":"Journal of Evidence-based Integrative Medicine","volume":"28 ","pages":"2515690X231211663"},"PeriodicalIF":3.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10631321/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"71482155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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