Journal of Evidence-based Integrative Medicine最新文献

{"title":"A Narrative Review of the Efficacy of Acupuncture in Chemotherapy-Induced Peripheral Neuropathy in Cancer Patients.","authors":"Li-Juan Chen, Li-Tian Ye, Jia-Yu Wang, Xuan Qiu","doi":"10.1177/2515690X251411764","DOIUrl":"10.1177/2515690X251411764","url":null,"abstract":"<p><p>ObjectiveThis review synthesizes current evidence on the efficacy of acupuncture in managing chemotherapy-induced peripheral neuropathy (CIPN) in cancer patients, focusing on its mechanisms, clinical applications, and future research directions.MethodsThis narrative review synthesizes and critically appraises findings from randomized controlled trials (RCTs), meta-analyses, and preclinical studies, evaluating acupuncture's impact on pain relief, neurological function, and quality of life. Key databases were searched for studies published up to 2024.ResultsNineteen RCTs (<i>n</i> = 1174) demonstrated significant improvements in CIPN symptoms with acupuncture, particularly in reducing neuropathic pain (eg, via endogenous opioid modulation) and enhancing sensory function (eg, BDNF-mediated neuroplasticity). Optimal protocols involved 2-3 sessions/week for 4-12 weeks, targeting acupoints such as ST36 and LI4. Acupuncture outperformed pharmacotherapy (eg, duloxetine) in safety and patient-reported outcomes.ConclusionAcupuncture is a promising adjunctive therapy for CIPN, offering multimodal mechanisms and clinical benefits. Standardization of protocols and further high-quality RCTs are needed to strengthen evidence and guide integration into oncology care.</p>","PeriodicalId":15714,"journal":{"name":"Journal of Evidence-based Integrative Medicine","volume":"31 ","pages":"2515690X251411764"},"PeriodicalIF":3.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12759135/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145892578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neural and Behavioral Effects of Harp Music: Frontal Alpha Suppression and Reaction Times in Relation to Depression-Related Traits.","authors":"Misako Matsui, Yuri Masaoka, Nobuyoshi Koiwa, Motoyasu Honma, Akira Yoshikawa, Shota Kosuge, Miku Kosuge, Daiki Shoji, Shunsuke Sakakura, Katsunori Inagaki, Masahiko Izumizaki","doi":"10.1177/2515690X261418393","DOIUrl":"10.1177/2515690X261418393","url":null,"abstract":"<p><p>Background/ObjectivesHarp music has long been used for comfort and healing, yet its neural mechanisms remain unclear. This study examined how major and minor harp sounds influence frontal alpha activity, mood, and reaction times, with a focus on depression-related individual differences.MethodsParticipants listened to 3-min major and minor harp excerpts while EEG alpha activity was recorded. Subjective ratings of arousal, stress, comfort, and mood were assessed, followed by auditory and visual reaction-time tasks.ResultsIndividuals with lower depression scores showed marked frontal alpha suppression during harp listening, which was associated with faster auditory reaction times. Those with higher depression scores exhibited consistently lower frontal alpha power with minimal modulation by harp sounds.ConclusionsFrontal alpha suppression during harp listening may reflect enhanced auditory attentional processing in individuals with lower depression levels. These findings suggest that depression-related traits shape neural responsiveness to harp music and should be considered when evaluating its therapeutic potential.</p>","PeriodicalId":15714,"journal":{"name":"Journal of Evidence-based Integrative Medicine","volume":"31 ","pages":"2515690X261418393"},"PeriodicalIF":3.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12852580/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146093310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Saffron and Pregnancy: Cultural Practices, Beliefs, and Safety Evidence: An Integrative Review.","authors":"Aisha Alshdefat, Ahmad Ayed, Ibrahim Aqtam, Olabisi Ibitoye, Sophia Vincent, Atiya Al Furqani","doi":"10.1177/2515690X261455162","DOIUrl":"10.1177/2515690X261455162","url":null,"abstract":"<p><p>Background<i>Crocus sativus</i> L. is a culturally significant herbal remedy used by pregnant women in many regions, particularly in South Asia and the Middle East. Despite its widespread use, evidence regarding its clinical efficacy and safety profile remains limited and inconclusive.ObjectivesThis integrative review aims to synthesize cultural beliefs, reported use, and clinical evidence on saffron use during pregnancy and childbirth, and to critically evaluate evidence regarding its maternal and fetal safety and therapeutic potential.MethodsA systematic search of PubMed, Google Scholar, Scopus, and Web of Science was conducted to identify English-language articles from inception to June 2025. Included studies comprised clinical trials, observational studies, systematic reviews, and cultural accounts. Data were extracted on cultural beliefs, use patterns, clinical outcomes, and potential risks. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) framework guided study selection.ResultsTwelve studies were selected. Cultural practices strongly influence saffron use, with women consuming it to improve fetal complexion, maternal strength, and labor readiness. Clinical evidence indicates low-dose saffron (approximately 250 milligrams daily) may facilitate cervical ripening, reduce labor pain and anxiety, and shorten labor duration in term pregnancies. These effects are dose-dependent, with higher doses or occupational exposure linked to uterine stimulation and increased miscarriage risk.ConclusionsLow-dose saffron shows promise for improving labor outcomes, though excessive consumption poses significant risks. Saffron use is deeply rooted in cultural beliefs, underscoring the need for respectful, dialogue-based approaches to guide patients safely. Standardized preparations and long-term safety data are needed before clinical recommendations can be made.</p>","PeriodicalId":15714,"journal":{"name":"Journal of Evidence-based Integrative Medicine","volume":"31 ","pages":"2515690X261455162"},"PeriodicalIF":3.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13213103/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148015867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In Vitro Anti-Cancer Effects of <i>Artemisia sieberi</i> on Human Breast Cancer Cells: A Systematic Review.","authors":"Fatimah G Albani, Entissar S Alsuhaibani, Sahar S Alghamdi","doi":"10.1177/2515690X261418415","DOIUrl":"10.1177/2515690X261418415","url":null,"abstract":"<p><p><i>Artemisia sieberi</i> (Asteraceae) is a grey, dwarf, dry woolly shrub, locally known as \"Shih\" in Arab countries, with significant medicinal properties due to its content of up to 160 active compounds with anti-cancer activity. <i>A. sieberi</i> has been investigated for its potential effects in various cancer types, including breast cancer. The aim of this systematic review is to examine the <i>in vitro</i> evidence on the potential activity of <i>A. sieberi</i> extracts against breast cancer, specifically in MCF-7 and MDA-MB-231 cells. A search of PubMed, ScienceDirect, Scopus, Web of Science, and Google Scholar electronic databases was conducted for studies published from inception to 2024, following PRISMA guidelines and the Cochrane Handbook for Systematic Reviews. The search strategy applied was ((<i>Artemisia sieberi</i>) AND (anti-breast cancer)). The Quality Assessment Tool (QUIN tool) was used to assess the risk of bias for <i>in vitro</i> studies. Six <i>in vitro</i> experimental studies were included. These studies suggested that <i>A. sieberi</i> extracts may exert anti-breast cancer effects via multiple mechanisms, including apoptosis induction, cell growth inhibition, and gene expression modulation. However, the anticancer potential <i>of A. sieberi</i> against breast cancer has been explored only at a preliminary <i>in vitro</i> level. Future research should evaluate different <i>A. sieberi</i> extracts across diverse breast cancer cell lines, particularly treatment-resistant types such as triple negative breast cancer (TNBC), and extend to <i>in vivo</i> and clinical investigation.</p>","PeriodicalId":15714,"journal":{"name":"Journal of Evidence-based Integrative Medicine","volume":"31 ","pages":"2515690X261418415"},"PeriodicalIF":3.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12881324/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146131358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alleviating Job-Related Burnout in Medical Professionals through Guided Imagery Hypnotherapy.","authors":"Ying Choon Wu, Enrique Carrillosulub, Leon Lange, Nicole Wells, Paula Jackson, Thomas Thudiyanplackal, Paul J Mills","doi":"10.1177/2515690X261418396","DOIUrl":"10.1177/2515690X261418396","url":null,"abstract":"<p><p>This pilot study examines the impact of guided imagery hypnotherapy (GIH) on symptoms of job-related burnout in medical professionals. Nine adults (eight female) involved in direct medical care in the region of San Diego, California participated in eight consecutive weekly GIH sessions. Subjective measures of burn-out, compassion, and self-compassion were recorded roughly one week before the start of the hypnotherapy series (baseline session zero) and after the first, fourth, and final GIH sessions. Resting state electroencephalographic data (EEG) was also recorded at each of these measurement times. Additionally, EEG was recorded for the duration of the hypnotherapy protocol during sessions one, four, and eight. Two sets of frontal alpha asymmetry (FAA) scores were computed for each participant. First, for each session, FAA was derived from the cleaned, preprocessed EEG recorded for the full duration of the GIH protocol. Additionally, FAA was computed from segments of EEG centered on eleven key events associated with hypnosis and visualization during the protocol. Linear mixed model analysis revealed a reliable increase in self-compassion and a decrease in emotional exhaustion across the four measurement times. Further, a reliable shift toward left over right hemispheric dominance, indicated by increases in FAA, was observed both across and within sessions, suggesting an evolution toward approach-related self-regulation at short and longer time scales. These outcomes indicate the promising potential of GIH for alleviating symptoms of job-related burnout and improving self-regulation in response to challenging work situations.</p>","PeriodicalId":15714,"journal":{"name":"Journal of Evidence-based Integrative Medicine","volume":"31 ","pages":"2515690X261418396"},"PeriodicalIF":3.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12873069/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146119216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does <i>Crocus sativus</i> (Saffron) Have an Influence or Effect on Ocular Health: A Systematic Literature Review.","authors":"Sonia Ferrara, Janet Schloss","doi":"10.1177/2515690X261478846","DOIUrl":"10.1177/2515690X261478846","url":null,"abstract":"<p><p>Background<i>Crocus sativus</i> (Saffron) and its bioactive constituents, crocin and crocetin have gained attention for their neuroprotective and antioxidant properties in ocular health. This review synthesises clinical evidence from extracted studies evaluating their efficacy, safety and dosing across Age-related Macular Degeneration (AMD), Primary Open-Angle Glaucoma (POAG), Diabetic Macular Edema (DME), Central Serous Retinopathy (CSR), Stargardt Disease (STGD1) and Paediatric Myopia (PM).MethodologyA systematic literature review was undertaken assessing randomized trials, observational or cohort studies, case studies or series written in English between January 2015 to January 2025. Studies were identified using PubMed, AMED, CINHAL, ScienceDirect and Scopus as well as the grey literature.ResultsTen clinical trials were identified from 529 citations. Interventions involved oral supplementation of saffron (20-50mg/day), crocin (5-15mg/day) and crocetin (7.5mg/day) over durations ranging from 6 weeks to 12 months. Primary outcomes included visual acuity, retinal electrophysiology, intra-ocular pressure, macular thickness, and safety profiles.ConclusionSaffron, crocin and crocetin, demonstrate consistent efficacy and exceptional safety profiles across a range of ocular conditions. Saffron's dose-dependent therapeutic effects are a promising adjunctive therapy in ophthalmology. Further large-scale trials are warranted to confirm these findings and refine condition specific dosing.</p>","PeriodicalId":15714,"journal":{"name":"Journal of Evidence-based Integrative Medicine","volume":"31 ","pages":"2515690X261478846"},"PeriodicalIF":3.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13473767/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148758832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>Tacca chantrieri</i> (Andre) Crude Extract Promoted Immunity in the Elderly (<i>Ex-Vivo</i>), and Inhibited Pathogenic and Opportunistic Bacteria.","authors":"Chitsanucha Chatsakulphanit, Supranee Phanthanawiboon, Malinee Thanee, Kanin Salao, Patcharaporn Tippayawat, Chanvit Leelayuwat, Nisa Chuangchot, Auttawit Sirichoat, Arnone Nithichanon, Chatcharin Kamsom, Saitharn Papalee, Chalida Chuenchom, Wisitsak Phoksawat","doi":"10.1177/2515690X261418404","DOIUrl":"10.1177/2515690X261418404","url":null,"abstract":"<p><p>Background<i>Tacca chantrieri</i> (Andre), or the black bat flower, is commonly found in Southeast Asia; however, its effects on immunity have not been studied. This study aimed to investigate the effects of <i>T. chantrieri</i> crude extract on CD4+ T cell phenotypes and on the phagocytosis and oxidative burst of polymorphonuclear neutrophils (PMNs) in the elderly (ex-vivo). Its ability to inhibit opportunistic and pathogenic bacteria was also evaluated.Methods<i>T chantrieri</i> crude extract was obtained by ethanolic extraction. A total of eight elderly (age ≥65 years) were enrolled in the study. Investigations used flow cytometric analysis. Antimicrobial effects were explored by agar well diffusion and minimum inhibition concentration (MIC) testing.ResultsCD4+ T cell proportion significantly decreased at the 100 μg/ml concentration (<i>p</i> = 0.015). CD4+NKG2D+ T cells decreased at all concentrations (50, 100, 200, 300 μg/ml). Regarding PMNs, phagocytosis and oxidative burst in the treated group were significantly increased at 15 min compared with the untreated group (<i>p</i> = 0.039 and 0.015, respectively). Regarding antimicrobial effect, 100 mg/ml crude extract inhibited <i>Staphylococcus epidermidis, Staphylococcus aureus</i>, <i>Neisseria sicca</i>, and <i>Acinetobacter lwoffii</i>. MIC values were 1.23, 3.70, 33.33, and 100 mg/ml, respectively.ConclusionsThis work reports preliminary findings of immunity promotion in the elderly following treatment with <i>T. chantrieri</i> crude extract. In future, the extract may be developed into a natural herb product or a form of alternative medicine for immune status enhancement, as well as a potential antimicrobial agent, particularly in the elderly.</p>","PeriodicalId":15714,"journal":{"name":"Journal of Evidence-based Integrative Medicine","volume":"31 ","pages":"2515690X261418404"},"PeriodicalIF":3.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12833147/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146040804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Syndrome Differentiation on Treatment Effects and side Effects of Chinese Herbal Medicine in Randomized Controlled Trials: A Meta-Epidemiological Study.","authors":"Claire C W Zhong, Betty Huan Wang, Mary Y Jiang, Irene X Y Wu, Leonard Ho, Fai Fai Ho, Shan Shan Xu, Ming Hong Kwong, Joson H S Zhou, Jason K C Lam, Vincent C H Chung","doi":"10.1177/2515690X261422020","DOIUrl":"10.1177/2515690X261422020","url":null,"abstract":"<p><p>ObjectiveIn Traditional Chinese medicine (TCM), syndrome differentiation is considered to be an essential diagnostic process for tailoring Chinese herbal medicine (CHM) treatments to individual patients. We conducted a meta-epidemiological study to evaluate the potential impact of syndrome differentiation on improving effect estimates in randomized controlled trials (RCTs).Study Design and SettingSeven databases were searched to identify systematic reviews (SRs) published between 2021 and 2022 that pooled RCTs evaluating CHM treatment effects or side effects. Meta-epidemiological analyses were conducted using a two-step approach. Subgroup analyses were performed based on the disease category, outcome nature, and funding.ResultsWe included 137 SRs comprising 2,064 RCTs. The results demonstrated small and statistically nonsignificant differences in both treatment effects (ROR: 0.93, 95% confidence interval (CI): 0.86 to 1.00, <i>P</i> = .04 for binary outcomes; dSMD: -1.44, 95% CI: -3.95 to 1.08, <i>P</i> = .26 for continuous outcomes) and side effects (ROR: 1.13, 95% CI: 0.66 to 1.92, <i>P</i> = .66) between RCTs that incorporated syndrome differentiation and those did not. Subgroup analysis showed RCTs of gastrointestinal disease that incorporated syndrome differentiation exhibited a larger magnitude of side effects than that did not. For binary outcomes, subgroup analyses of RCTs of circulatory diseases or those reporting subjective outcomes showed that syndrome differentiation led to a statistically significantly smaller treatment effect.ConclusionIndividualizing CHM treatments through syndrome differentiation provide no significant evidence of improvement in TCM practice outcomes in RCTs. Furthermore, subgroup analyses suggest that syndrome differentiation may be associated with a smaller treatment effect among RCTs of CHM for circulatory diseases and a possible trend toward increased side effects in patients with gastrointestinal diseases.</p>","PeriodicalId":15714,"journal":{"name":"Journal of Evidence-based Integrative Medicine","volume":"31 ","pages":"2515690X261422020"},"PeriodicalIF":3.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12894648/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146165511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Complementary and Alternative Medicine Utilization: Moving Beyond Prevalence Estimates Toward Context-Specific Integration and Health Policy.","authors":"Leandro John Aglusulos","doi":"10.1177/2515690X261487761","DOIUrl":"10.1177/2515690X261487761","url":null,"abstract":"","PeriodicalId":15714,"journal":{"name":"Journal of Evidence-based Integrative Medicine","volume":"31 ","pages":"2515690X261487761"},"PeriodicalIF":3.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13546420/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148887222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-Term Effects of Yoga Practice on Metabolic, Hormonal, and Anthropometric Parameters in Climacteric Women.","authors":"Laura Alves Cota E Souza, Ilka Afonso Reis, Angélica Alves Lima","doi":"10.1177/2515690X261437460","DOIUrl":"10.1177/2515690X261437460","url":null,"abstract":"<p><p>Metabolic and hormonal disturbances are common during the climacteric period and contribute to an increased risk of chronic diseases. Yoga has emerged as a promising complementary approach to promote women's health during midlife; however, long-term evidence remains limited. This longitudinal, community-based controlled study evaluated the effects of regular yoga practice over 24 months on anthropometric, metabolic, and hormonal parameters in climacteric women. A total of 182 Brazilian women aged 40-65 were followed; participants who chose to engage in yoga formed the intervention group, while sedentary women served as controls. Data were collected at baseline and after 6, 12, and 24 months. After 24 months, the yoga group showed significant reductions in BMI (-2.24 kg/m²; p = 0.008) and body fat percentage (-4.29%; p = 0.008), as well as decreases in systolic (-11.4 mm Hg; p = 0.012) and diastolic blood pressure (-5.5 mm Hg; p = 0.044). Improvements were also observed in fasting glucose (-9.1 mg/dL; p = 0.024), QUICKI (+0.03; p = 0.046), HDL-c (+9.6 mg/dL; p = 0.012), and non-HDL-c (-23.4 mg/dL; p = 0.018). Estradiol levels increased by 24.4 pg/mL in the yoga group and were significantly higher than in controls at 24 months (+40.9 pg/mL; p < 0.001), suggesting an endocrine-modulating effect. These findings support yoga as a promising nonpharmacological strategy to promote metabolic and hormonal health during the climacteric phase.</p>","PeriodicalId":15714,"journal":{"name":"Journal of Evidence-based Integrative Medicine","volume":"31 ","pages":"2515690X261437460"},"PeriodicalIF":3.4,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13452939/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148697539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}