Journal of Evidence-based Integrative Medicine最新文献

{"title":"Ganoderma Spore Lipids Inhibit Perineural Invasion in Pancreatic Cancer by Downregulating NGF-TrkA Pathway.","authors":"Haohui Lin, Manhon Chung, Yi Yang, Li Zhang, Xiaohua Pan, Sa Cai, Yu Pan","doi":"10.1177/2515690X251356473","DOIUrl":"10.1177/2515690X251356473","url":null,"abstract":"<p><p>Perineural invasion (PNI) is an important factor leading to the recurrence of pancreatic cancer (PanCa). The NGF-TrkA pathway is related to PNI progression. <i>Ganoderma</i> spore lipid (GSL) is a drug with anti-cancer properties. In this study, we find out whether GSL can prevent PNI of PanCa by inhibiting NGF-TrkA pathway. <i>In vitro</i>, wound healing assays, transwell-based assays and three-dimensional tumor-nerve cell co-culture system showed that GSL significantly inhibited the migration and invasion capacity of PanCa cells. Inhibiting the NGF-TrkA pathway is considered an effective approach for treating PanCa. We showed that GSL effectively inhibited NGF-TrkA pathway <i>via</i> immunofluorescence assays and western blotting analysis. The supplement of recombinant NGF reversed the GSL inhibitory effect on the migration and invasion of PANC-1. <i>In vivo</i>, a sciatic nerve invasion animal model was constructed using BALB/c mice. GSL significantly suppressed tumor growth and suppressed the expression of TrkA, NGF, and vimentin and upregulated the level of the epithelial marker E-Cadherin. Moreover, GSL reduced the expression of S100 and PGP9.5. These findings suggested that GSL effectively inhibited the PNI of PanCa cells by downregulating the NGF-TrkA pathway, which may provide a new adjuvant for PanCa treatment.</p>","PeriodicalId":15714,"journal":{"name":"Journal of Evidence-based Integrative Medicine","volume":"30 ","pages":"2515690X251356473"},"PeriodicalIF":3.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12246538/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144584039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of Yoga in Distinctly Targeting Modifiable Risk Factors in Type 2 Diabetes to Improve Immuno-Metabolic Axis.","authors":"Harshit B Joshi, Aswathy S Nair, Ramya Bellave, Krishna Raghava Hebbar, Anupama Nayak, Nandi Krishnamurthy Manjunath, Shashikiran Umakanth, Basavaraj Hadapad, Manjunath B Joshi","doi":"10.1177/2515690X251345730","DOIUrl":"https://doi.org/10.1177/2515690X251345730","url":null,"abstract":"<p><p>Modifiable and non-modifiable risk factors in Type 2 Diabetes (T2D) contribute to chronic inflammation characterized by elevated pro-inflammatory mediators and constitutively activated immune cells. Chronic inflammation in T2D leads to perturbations in metabolism, resulting in altered immuno-metabolic axis and further vascular complications. Hence, reducing inflammation by targeting modifiable risk factors such as adiposity, sedentary lifestyle and psychological stress in T2D may facilitate efficient clinical management. Yoga has been shown to improve glucose metabolism, reduce psychological stress, and decrease obesity, hence we sought to review the role of Yoga on cellular mechanisms regulating the immuno-metabolic axis in T2D. Elevated levels of inflammatory mediators such as IL-1b, IL-6, TNF-a, and CRP contributing to insulin resistance are reduced upon practicing Surya Namaskara, Pranayama, and meditation and further improved glycemic index in T2D individuals. Specific Asanas and Pranayama significantly decreased adipokines including leptin, adiponectin, and vaspin in subjects with high BMI, triglycerides and HOMA-IR values, and concomitantly reduced inflammation. Bidirectional activation of inflammatory mediators and stress hormones including epinephrine, catecholamines and cortisol manifesting in diabetes are also reduced upon practising meditation and Yoga. Yoga practices such as Pranayama, Asanas and Mudras improve insulin sensitivity, contribute to weight management, mitigate stress levels in T2D, and maintain immuno-metabolic homeostasis.</p>","PeriodicalId":15714,"journal":{"name":"Journal of Evidence-based Integrative Medicine","volume":"30 ","pages":"2515690X251345730"},"PeriodicalIF":3.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144956511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Yiqi Jianpi Kangai Decoction Enhances the Chemotherapy Effect by Inducing Apoptosis and Regulating Treg and Th17 Cells in Colorectal Cancer Mice Model with Spleen Qi Deficiency.","authors":"Qinsha Wang, Shichao Li, Yao Fan, Weidong Chen, Qingfeng Jiang, Xin Sun, Qijun Lv, Wusheng Li, Yingtian Jia","doi":"10.1177/2515690X241313097","DOIUrl":"10.1177/2515690X241313097","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Colorectal Cancer (CRC) is widely prevalent worldwide and its incidence is increasing. Chemotherapy is an important treatment method for colorectal cancer in addition to surgery, but it often causes physical and mental pain to patients due to its side effects. TCM emphasizes evidence-based treatment and a holistic concept, and the combination of TCM and chemotherapy can reduce chemotherapy side effects, improve chemotherapy efficacy, and enhance patients' immunity. Yiqi Jianpi Kangai Decoction (YQJP) has been used clinically to treat patients with advanced colorectal cancer and may improve their immune function and prognosis. However, its mechanism has not been elucidated.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Objective: &lt;/strong&gt;The study aims to explore the effect and mechanism of YQJP on enhancing the therapeutic effect of chemotherapy on spleen qi deficiency type CRC mice.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;We used HPLC/MS to characterize the active substance components in YQJP. We established the spleen qi deficiency model induced by using the compound methods of diarrhea of bitter and cold, starvation, and full and excessive labor. and then inoculated CT-26 mouse colon cancer cells subcutaneously to establish the CRC Mice. We also evaluated the efficacy and mechanism of YQJP by using oral Yiqi Jianpi Kangai Decoction combined with an intraperitoneal injection of chemotherapeutic drugs (FOLFOX regimen). We evaluated the efficacy and safety of YQJP by observing the general condition (body weight, tumor size, food intake, hair condition, stool condition), HE staining, blood routine, and organ index of the mice. The expression of CD8&lt;sup&gt;+&lt;/sup&gt;, CD4&lt;sup&gt;+&lt;/sup&gt; T cells, Th17 cells, and Treg cells in the tumor and spleen were detected by flow cytometry, and the levels of IL-17, IL-10, IFN-γ and TGF-β in the tumor were detected by ELISA; the expression of Ki-67, PCNA, RORγt and FOXP3 proteins in the tumor was detected by immunohistochemistry.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;YQJP contains 7 herbal compounds, which can effectively improve body weight, spleen condition, and bone marrow suppression in tumor-bearing mice inhibit tumor growth, and do not damage tissues and organs, which initially confirmed the anti-cancer effect and safety of YQJP. Further experiments showed that YQJP could elevate the proportion of CD8&lt;sup&gt;+&lt;/sup&gt;, CD4&lt;sup&gt;+&lt;/sup&gt; T cells in the spleen, increase the proportion of Th17 cells in the tumor tissue of mice, and decrease the level of Treg cells. It can inhibit the expression of Ki-67 and PCNA. Meanwhile, it promotes the expression of IL-17 and IFN-γ and inhibits the expression of IL-10 and TGF-β. In addition, it can reduce the relative expression of FOXP3 and increase the relative expression of RORγt.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;The combination of YQJP with chemotherapy had the effect of tumor suppression and enhanced chemotherapeutic efficacy in the spleen qi deficiency CRC mice. The related mechanism may be r","PeriodicalId":15714,"journal":{"name":"Journal of Evidence-based Integrative Medicine","volume":"30 ","pages":"2515690X241313097"},"PeriodicalIF":3.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11843709/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143468034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Meta-Analysis of Studies of the Effect of Mind Body Exercise on Various Domains of Cognitive Function in Older People With or Without Mild Cognitive Impairment.","authors":"Ji-Woo Suk, Kahye Kim, Jaeuk U Kim","doi":"10.1177/2515690X251363709","DOIUrl":"10.1177/2515690X251363709","url":null,"abstract":"<p><p>Objectivethis meta-analysis evaluates the effects of mind-body exercise (MBE) on cognitive function in older adults with or without mild cognitive impairment (MCI). We examined the impact of different MBE, including yoga, tai chi, qigong, and meditation, on six cognitive domains: attention, executive function, working memory, verbal memory, processing speed, and visual-spatial construction.MethodsWe searched eight electronic databases from inception till August 2024. The literature search, study selection, data extraction, methodological quality assessment and statistical analyses were performed.ResultsA total of 45 studies, comprising 4602 participants, were included. Results indicated that MBE had a moderate positive effect on visual-spatial construction (Hedges' <i>g</i> = 0.46) and small effects on other domains such as verbal memory (Hedge's <i>g</i> = 0.24), processing speed (Hedge's <i>g</i> = 0.26), working memory (Hedges' <i>g</i> = 0.15) and executive function (Hedges' <i>g</i> = 0.10). However, there was no improvement in attention (Hedge's <i>g</i> = 0.08, 95% CI = -0.07 to 0.23). The meta-regression analysis further revealed that participants with MCI experienced greater improvements in visual-spatial construction and executive function than healthy participants. Additionally, significant differences were observed among intervention types, with yoga and tai chi showing stronger effects on visual-spatial construction and verbal memory than meditation.ConclusionsThese findings suggest MBE is an effective intervention for improving cognitive function, especially in MCI populations and with certain types of interventions. Utilization of validated modules for MBE intervention and inclusion of long-term follow-up assessments to establish conclusive findings were also suggested.</p>","PeriodicalId":15714,"journal":{"name":"Journal of Evidence-based Integrative Medicine","volume":"30 ","pages":"2515690X251363709"},"PeriodicalIF":3.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12329208/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144789296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and Safety of Warm Acupuncture Compared to Gabapentin for Pain Management in Patients with Sciatica in Bhutan: A Randomized Controlled (ACUWARM) Trial.","authors":"Dorji Gyeltshen, Thinley Dorji, Karma Tenzin, Tshering Choeda, Mongal Singh Gurung, Krit Pongpirul, Li Jing","doi":"10.1177/2515690X251355513","DOIUrl":"10.1177/2515690X251355513","url":null,"abstract":"<p><p>IntroductionSciatica is a significant health issue, primarily affecting the young population, and causes considerable distress. Acupuncture has been investigated as a potential treatment to address the gap in effective management options for sciatica. This study aimed to compare pain severity, disability, and quality of life, and adverse events in subjects with sciatica receiving warm acupuncture compared those receiving oral gabapentin.MethodsThis randomized controlled non-inferiority clinical trial involved the use of the minimization technique for randomization. Seventy participants were enrolled and divided into two groups: Warm Acupuncture Group and Gabapentin Group.ResultsOn Day 15, the Visual Analogue Scale (VAS) score was significantly lower in the acupuncture group compared to the gabapentin group (4.3 vs 5.2, <i>P</i> = .029). On Day 30, the VAS score further decreased in the acupuncture group (1.4 vs 3.6, <i>P</i> < .001). Warm acupuncture demonstrated non-inferiority in reducing low back pain at Day 30 and showed significant improvement in gluteal, thigh, and leg pain scores on Days 15 and 30. Improvements in disability scores were significantly higher in the acupuncture group on Days 15 (73.7% vs 22.3%) and Day 30 (92.3% vs 44.6%). No adverse events related to warm acupuncture were reported.ConclusionThe standardized protocol of warm acupuncture was non-inferior to gabapentin in reducing pain severity by Days 15 and 30. Warm acupuncture resulted in higher improvements in disability scores with no reported adverse events. Thus, warm acupuncture presents a viable alternative to gabapentin for managing pain in patients with sciatica.</p>","PeriodicalId":15714,"journal":{"name":"Journal of Evidence-based Integrative Medicine","volume":"30 ","pages":"2515690X251355513"},"PeriodicalIF":3.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12227939/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144560268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Body Acupuncture Conjunction with Rehabilitation for Upper Limb Improves Motor Functions in Children with Spastic Hemiplegic Cerebral Palsy: A Pilot Study.","authors":"Hui Wang, Yu Du, Tong Chen, Zheng-Huan Mao, Jia-Yu Xu, Li Ding, Wen-Cong Ruan, Hai-Feng Li","doi":"10.1177/2515690X251317438","DOIUrl":"10.1177/2515690X251317438","url":null,"abstract":"<p><strong>Objective: </strong>Aimed to investigate the effectiveness of body acupuncture on motor function of the upper limb in children with spastic hemiplegic cerebral palsy (CP) conjunction with rehabilitation program.</p><p><strong>Design: </strong>The study is a randomized controlled experimental trial. Children with CP were randomly divided into the acupuncture group (body acupuncture with rehabilitation) and the rehabilitation group. The muscle volume difference between the upper limbs, the fine motor scores of the Peabody developmental motor scale-2 (PDMS-FM) and the surface electromyography (SEMG) parameter-root mean square (RMS)-on upper limb muscles (biceps brachii, radial wrist extensors and pronator teres) of both groups were measured before and after a 12-week treatment.</p><p><strong>Results: </strong>37 children completed the study. In the two groups, differences in muscle volume, PDMS-FM scores and RMS values (biceps brachii, radial wrist extensors and pronator teres) were significantly improved, except PDMS-FM score difference and difference of RMS values (biceps brachii, radial wrist extensors and pronator teres) between the upper limbs in the rehabilitation group. Comparison post-treatment/pre-treatment change for two groups showed significant difference in affected upper limb PDMS-FM total score, PDMS-FM score difference between the upper limbs, affected upper limb RMS values and RMS value difference between the upper limbs in favor of the acupuncture group.</p><p><strong>Conclusion: </strong>Our preliminary research indicates that body acupuncture therapy combined with rehabilitation may be more effective than rehabilitation alone, further improving muscle strength of affected upper limb and possibility of bimanual coordination in children with spastic hemiplegic CP.</p>","PeriodicalId":15714,"journal":{"name":"Journal of Evidence-based Integrative Medicine","volume":"30 ","pages":"2515690X251317438"},"PeriodicalIF":3.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11831640/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143433266","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to \"Efficacy and safety of warm acupuncture compared to gabapentin for pain management in patients with sciatica in Bhutan: a randomized controlled (ACUWARM) trial\".","authors":"","doi":"10.1177/2515690X251378411","DOIUrl":"10.1177/2515690X251378411","url":null,"abstract":"","PeriodicalId":15714,"journal":{"name":"Journal of Evidence-based Integrative Medicine","volume":"30 ","pages":"2515690X251378411"},"PeriodicalIF":3.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12417657/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145015578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New Therapy for Chronic Sarcoidosis with <i>Viscum Album</i> L. and Ferrum Chloratum Preparations: Results of a Retrospective Survey.","authors":"Christian Grah, Irina Gatov, Shiao Li Oei, Marcus Reif, Hannah Wüstefeld, Annika Marzok","doi":"10.1177/2515690X251345931","DOIUrl":"10.1177/2515690X251345931","url":null,"abstract":"<p><p>BackgroundSarcoidosis is a chronic, inflammatory, granulomatous, multisystem disease. At the Department of Pneumology of the hospital Gemeinschaftskrankenhaus Havelhöhe, the treatment of sarcoidosis is complemented with a multi-component mixture based on <i>Viscum album L.</i>, mistletoe extracts and Ferrum chloratum according to the Havelhöhe Sarcoidosis Protocol (HSP). The aim of this study was to evaluate the course of disease in sarcoidosis patients treated with HSP.MethodsA retrospective cohort study was conducted by evaluating data on clinical progression, pulmonary function, fatigue, and adverse events in a real-world sarcoidosis cohort using descriptive statistics.Results956 patients with sarcoidosis were treated with HSP between 2003 and 2022 and a total of 124 consenting patients (all stages, 35% multi-organ sarcoidosis, mean age 43 years, 69% female) were evaluated for clinical outcomes over a median follow-up of 23 months. The response rate for controlling pulmonary disease in this study cohort was 69%. At baseline, 81 patients (65%) had clinically relevant fatigue, which improved in 48 patients (59%) during HSP therapy. At the last follow-up visit, 103 (83%) did not need glucocorticosteroids or other medications and were receiving only HSP. Pharmacovigilant monitoring demonstrated a safe HSP therapeutic profile, with only 10 (8%) subjects experiencing grade 1 adverse events.ConclusionThe feasibility and safety of complementary HSP therapy in the treatment of sarcoidosis have been demonstrated. These results should be used for the creation of hypotheses and further investigations.</p>","PeriodicalId":15714,"journal":{"name":"Journal of Evidence-based Integrative Medicine","volume":"30 ","pages":"2515690X251345931"},"PeriodicalIF":3.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12144380/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144234251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of Dry Needling Combined with Eccentric Exercise Versus Oral and Topical NSAID Treatment in Patients with Tennis Elbow: A Randomized Controlled Trial.","authors":"Zacarías Sánchez-Milá, Vanesa Abuín-Porras, Helena Fidalgo-Gómez, Isabel Mínguez-Esteban, Jaime Almazán-Polo, Jorge Velázquez-Saornil","doi":"10.1177/2515690X251355017","DOIUrl":"10.1177/2515690X251355017","url":null,"abstract":"<p><p>ObjectiveThe study aimed to compare the effects of a combined intervention of dry needling and eccentric exercises versus oral and topical NSAID treatment, each combined with eccentric exercises, on pain intensity and hand function in patients with lateral epicondylalgia.DesignA single-blind, randomized controlled trial.MethodsA total of 111 participants with LE were randomly assigned to three groups: Dry needling plus eccentric exercise, Oral treatment plus eccentric exercise, and Topical treatment plus eccentric exercise. Pain intensity was assessed using the Visual Analog Scale and pressure pain threshold at the lateral epicondyle, medial epicondyle, radial styloid, and ulnar styloid. Functional impairment was measured using the HAND10 questionnaire. Statistical analysis included repeated measures ANOVA and post-hoc tests.ResultsAll groups showed significant improvements in pain intensity and function over the 30-day intervention period The DN group achieved the most substantial reduction in pain and the greatest improvement in pressure pain threshold and functional scores, followed by the TopA group. The OralI group demonstrated the least improvement across all measures. Significant differences were found between the three groups,with the dry needling group outperforming both Oral and Topical treatment groups in pain relief and functional outcomes.ConclusionThe combination of dry needling and eccentric exercises was more effective in reducing pain and improving hand function compared to NSAID-based interventions. These findings support the use of dry needling as an adjunct therapy to eccentric exercises for the management of lateral epicondylalgia.<b>Clinical Trials Registry number:</b> NCT05021354.</p>","PeriodicalId":15714,"journal":{"name":"Journal of Evidence-based Integrative Medicine","volume":"30 ","pages":"2515690X251355017"},"PeriodicalIF":3.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12254548/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144591391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High-intensity Interval Training and Mindfulness Breathing Induce Hormonal, Metabolic, and Anticarcinogenic Effects in Obese Postmenopausal Women: A Randomized Controlled Trial.","authors":"Ebtesam N Nagy, Marwa Shafiek, Hend Elsheimy, Hussein G Mogahed, Marwa M Elsayed","doi":"10.1177/2515690X251372718","DOIUrl":"10.1177/2515690X251372718","url":null,"abstract":"<p><p>ObjectiveTo find out the effect of high-intensity interval training (HIIT) and mindfulness breathing on the levels of sex hormones, insulin resistance, lipid profiles, and tumor biomarkers in postmenopausal obese women.DesignSeventy obese postmenopausal women (aged 55-65 years, with a body mass index (BMI) ranging from 35-44.9 kg/m²) were allocated into two groups for this prospective, randomized, controlled study: the experimental group, which received HIIT and mindfulness breathing in addition to their medications, and the control group, which only received medication. Serum sex hormone levels (estradiol, total testosterone [TT], free testosterone [FT], and sex hormone-binding globulin [SHBG]), insulin resistance assessment using the homeostasis model [HOMA-IR], lipids (total cholesterol [TC], triglycerides [TGs], high-density lipoprotein [HDL], and TC/HDL), and tumor markers (Carcino Embryonic Antigen [CEA] and Cancer Antigen [CA125]) were among the pre and post assessments conducted after 12 weeks.ResultsAfter 12 weeks of the study, the HIIT and mindfulness breathing group showed significant decreases in weight, BMI, FT, TT, estradiol, HOMA-IR, CEA, CA125, TC, TGs, and TC/HDL and increases in SHBG and HDL (all <i>p</i> < 0.001). In contrast, the control group had increases in weight, BMI, FT, TT, estradiol, HOMA-IR, CEA, CA125, TC, TGs, and TC/HDL and decreases in SHBG and HDL (all <i>p</i> < 0.001).ConclusionHIIT and mindfulness breathing were efficient approaches for lowering metabolic, hormonal, and tumor-related risk factors in obese postmenopausal women.</p>","PeriodicalId":15714,"journal":{"name":"Journal of Evidence-based Integrative Medicine","volume":"30 ","pages":"2515690X251372718"},"PeriodicalIF":3.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12405701/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144956494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}