Journal of Evidence-based Integrative Medicine最新文献

{"title":"An Assay on the Possible Effect of Essential Oil Constituents on Receptors Involved in Women's Hormonal Health and Reproductive System Diseases.","authors":"Amirhossein Sakhteman,&nbsp;Ardalan Pasdaran,&nbsp;Mehdi Afifi,&nbsp;Azadeh Hamedi","doi":"10.1177/2515690X20932527","DOIUrl":"https://doi.org/10.1177/2515690X20932527","url":null,"abstract":"<p><p>Aromatic herbal remedies, hydrosols, and essential oils are widely used for women's hormonal health. Scientific investigation of their major constituents may prevent unwanted infertility cases, fetal abnormalities, and drug-herb interactions. It also may lead to development of new medications. A list of 265 volatile molecules (mainly monoterpenes and sesquiterpenes) were prepared from a literature survey in Scopus and PubMed (2000-2019) on hydrosols and essential oils that are used for women's hormonal and reproductive health conditions. The PDB (protein data bank) files of the receptors (136 native PDB files) that involve with oxytocin, progesterone, estrogen, prolactin, acetyl choline, androgen, dopamine, human chorionic gonadotropin, luteinizing hormone, follicle-stimulating hormone, aromatase, and HER2 receptors were downloaded from Protein Data Bank. An in silico study using AutoDock 4.2 and Vina in parallel mode was performed to investigate possible interactions of the ligands with the receptors. Drug likeliness was investigated for the most active molecules using DruLiTo software. Aristola-1(10),8-diene, bergapten (5-methoxypsoralen), α-bergamotene, bicyclogermacrene, α-bisabolol oxide A, α-bisabolone oxide, <i>p</i>-cymen-8-ol, 10-epi elemol, α-elemol, β-eudesmol, 7-<i>epi</i>-β-eudesmol, ficusin, β-humulene, methyl jasmonate, nerolidol, pinocarvone, (+)-spathulenol, and thujone had better interactions with some androgen, aromatase, estrogen, progesterone, HER2, AChR, and/or dopamine receptors. Most of these molecules had an acceptable drug likeliness except for α-bergamotene, bicyclogermacrene, β-humulene, and aristola-1(10),8-diene. Some volatile natural molecules can be considered as lead compound for drug development to treat hormonal conditions.</p>","PeriodicalId":15714,"journal":{"name":"Journal of Evidence-based Integrative Medicine","volume":"25 ","pages":"2515690X20932527"},"PeriodicalIF":3.5,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/2515690X20932527","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38071346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors Associated With Medication Use Among Individuals Living With Multiple Sclerosis.","authors":"Khrisha B Alphonsus,&nbsp;Carl D'Arcy","doi":"10.1177/2515690X20936978","DOIUrl":"https://doi.org/10.1177/2515690X20936978","url":null,"abstract":"<p><p>Multiple sclerosis (MS) is a chronic autoimmune disease that affects the central nervous system causing neurological deterioration over time. The objective of this study was to examine the predictors associated with MS medication use. The categories that were investigated were various alternative treatments such as complementary/alternative medications (CAMs), rehabilitation therapy and psychotherapy services as well as comorbid health conditions. The Survey on Living with Neurological Conditions in Canada (SLNCC) 2011-2012 was used (N = 73 347) to carry out a logistic regression model. Individuals who did not take CAMs were more (OR = 5.44, 95% CI 1.37-9.29) likely to use medications for MS. Having a mood disorder was associated with greater use of MS medications (OR = 5.39, 95% CI 1.60-18.17) while back problems were associated with lower odds of medication use (OR = 0.38, 95% CI 0.15-0.98). These factors need to be taken into consideration when creating effective medication adherence interventions.</p>","PeriodicalId":15714,"journal":{"name":"Journal of Evidence-based Integrative Medicine","volume":"25 ","pages":"2515690X20936978"},"PeriodicalIF":3.5,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/2515690X20936978","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38113195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation of the In Vitro Antioxidant Potential Of Polyphenolic-Rich Extract of <i>Artocarpus heterophyllus</i> Lam Stem Bark and Its Antidiabetic Activity In Streptozotocin-Induced Diabetic Rats.","authors":"Basiru Olaitan Ajiboye,&nbsp;Oluwafemi Adeleke Ojo,&nbsp;Babatunji Emmanuel Oyinloye,&nbsp;Mary Abiola Okesola,&nbsp;Adeyonu Oluwatosin,&nbsp;Aline Augusti Boligon,&nbsp;Abidemi Paul Kappo","doi":"10.1177/2515690X20916123","DOIUrl":"https://doi.org/10.1177/2515690X20916123","url":null,"abstract":"<p><p><i>Artocarpus heterophyllus</i> Lam (Moraceae) stem bark has been used locally in managing diabetes mellitus with sparse scientific information. This study investigates the in vitro antioxidant potential of polyphenolic-rich extract of <i>A heterophyllus</i> stem bark as well as its antidiabetic activity in streptozotocin-induced diabetic rats. Fifty male Wistar rats were used with the induction of diabetes by a single intraperitoneal injection of streptozotocin (45 mg/kg body weight) and were orally administered 400 mg/kg free and bound phenols of <i>A heterophyllus</i> stem bark. The animals were sacrificed on the 28th day of the experiment using the cervical dislocation method; antihyperglycemia and anti-inflammatory parameters were subsequently assessed. The polyphenolic extracts demonstrated antioxidant potentials (such as hydrogen peroxide and diphenyl-1-picrylhydrazyl), as well as strong inhibitory activity against amylase and glucosidase. There was a significant (<i>P</i> < .05) increase in glycogen, insulin concentration, pancreatic β-cell scores (HOMA-β), antioxidant enzymes and hexokinase activities, as well as glucose transporter concentration in diabetic animals administered the extracts and metformin. Also, a significant (<i>P</i> < .05) reduction in fasting blood glucose, lipid peroxidation, glucose-6-phosphatase, and all anti-inflammatory parameters were observed in diabetic rats administered the extracts and metformin. The extracts demonstrated antidiabetic potential, which may be useful in the management of diabetes mellitus.</p>","PeriodicalId":15714,"journal":{"name":"Journal of Evidence-based Integrative Medicine","volume":"25 ","pages":"2515690X20916123"},"PeriodicalIF":3.5,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/2515690X20916123","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37950293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ethnobotany of Medicinal Plants Used by Rakhine Indigenous Communities in Patuakhali and Barguna District of Southern Bangladesh.","authors":"A T M Rafiqul Islam,&nbsp;Mahadiy Hasan,&nbsp;Tahidul Islam,&nbsp;Ashikur Rahman,&nbsp;Shawon Mitra,&nbsp;Subroto K Das","doi":"10.1177/2515690X20971586","DOIUrl":"https://doi.org/10.1177/2515690X20971586","url":null,"abstract":"<p><p>An extensive study has been made to identify, document, and investigate the ethnomedicinal plants used by Rakhine ethnic minorities in Patuakhali and Barguna District of southern Bangladesh for the term of April 2018 to June 2019. In this article, we have focused on the Rakhine population trends, management concerns, and some actions for conserving the Rakhine population diversity in the study area. In this study, we have identified the locations where Rakhine population lives in Patuakhali and Barguna districts. A total of 86 plant species belonging to 71 genera and 43 families were reported to be used for treating more than 57 various physical ailments under 14 illness categories from the study area. For each of the species, the botanic name, common name, Rakhine name, family, habit, parts used and traditional medicinal uses of the plant species have been presented. The maximum numbers of ethnomedicinal plant species were utilized to treat gastrointestinal complaints (43) taken after by the treatment of dermatological issues (36). The highly cited (75.60%) plant species were found to be <i>Ananas comosus</i> and <i>Aegle marmelos</i> used for gastro-intestinal (Stomach pain, indigestion, and dysentery) digestive disorders and subsequently followed by <i>Colocasia esculenta</i> (70.73%) used for cut, bleeding and wound healing. The results of this study have shown that Rakhine indigenous communities still depend on conventional plant-based medication to remedy various diseases and therapeutic purposes in the study area. Our findings have also shown that despite there have adequate phytodiversity in the natural habitat of the study area but the number of Rakhine population has been declining significantly day-by-day. As an ultimate result, we have lost the plant-based traditional medicinal knowledge of Rakhine indigenous communities in Bangladesh. As a rich source of traditional knowledge and cultural diversity, it calls for urgent initiatives to conserve the cultural heritage of the Rakhine community as well as the diversity of Rakhine ethnic group.</p>","PeriodicalId":15714,"journal":{"name":"Journal of Evidence-based Integrative Medicine","volume":"25 ","pages":"2515690X20971586"},"PeriodicalIF":3.5,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/2515690X20971586","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38746273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of In Vivo Antidiabetic, In Vitro α-Amylase Inhibitory, and In Vitro Antioxidant Activity of Leaves Crude Extract and Solvent Fractions of <i>Bersama abyssinica</i> Fresen (Melianthaceae).","authors":"Zemene Demelash Kifle,&nbsp;Engidaw Fentahun Enyew","doi":"10.1177/2515690X20935827","DOIUrl":"https://doi.org/10.1177/2515690X20935827","url":null,"abstract":"<p><strong>Background: </strong>The leaves of <i>Bersama abyssinica</i> are used for the treatment of diabetes mellitus in folk medicine system of Ethiopia. The present study was done based on the traditional claim of <i>B abyssinica</i> for the treatment of diabetes mellitus.</p><p><strong>Methods: </strong>The α-amylase inhibition and antioxidant activities of <i>B abyssinica</i> extracts were evaluated by using 3,5-dinitrosalicylic acid method and diphenyl-2-picrylhydrazyl assay model, respectively. Blood glucose lowering activity of the extracts was studied in 4 animal models; normoglycemic, oral glucose loaded, and streptozotocin-induced diabetic mice models.</p><p><strong>Results: </strong>Among the extracts, the crude extract showed the highest α-amylase enzyme inhibition activity with an IC₅₀ of 6.57 μg/mL. The water fraction showed the strongest antioxidant activity with an IC₅₀ of 3.43 μg/mL. The crude extract at doses of 200, and 400 mg/kg showed significant (<i>P</i> < .05) hypoglycemic activity in normoglycemic mice. All doses of the crude extract significantly (<i>P</i> < .05) reduced blood glucose levels of oral glucose-loaded mice. In streptozotocin-induced diabetic mice models, both the crude and solvent fractions showed a significant (<i>P</i> < .05) blood glucose lowering effect as compared with the negative control group post 8 hour treatment.</p><p><strong>Conclusion: </strong>The results demonstrated the beneficial biochemical effects of <i>B abyssinica</i> extract by inhibiting α-amylase and scavenging the free radicals. The crude extract and solvent fractions of <i>B abyssinica</i> had significant blood glucose lowering effect in all animal models.</p>","PeriodicalId":15714,"journal":{"name":"Journal of Evidence-based Integrative Medicine","volume":"25 ","pages":"2515690X20935827"},"PeriodicalIF":3.5,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/2515690X20935827","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38197232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Court-Type Thai Traditional Massage Versus Senokot Treatment on Chronic Constipation: A Randomized Controlled Trial.","authors":"Jurairat Boonruab,&nbsp;Phiyaphon Poonsuk,&nbsp;Watchara Damjuti","doi":"10.1177/2515690X20960644","DOIUrl":"https://doi.org/10.1177/2515690X20960644","url":null,"abstract":"<p><p>Chronic constipation is the disturbances of intestinal motility which is a challenge in primary healthcare around the world. In this study, Court-type Thai traditional massage and Senokot, treatments were assessed and compared in terms of their efficacy in relieving constipation. Forty subjects diagnosed with constipation were recruited and randomized into the massage group and drug group. For 7 days, Thai traditional abdominal massage was provided regularly for the patients in the massage group, while the drug group was subjected to Senokot treatment only. The Bristol stool chart scale and demographics questionnaire were used as instruments. As a result, both court type Thai traditional massage and Senokot are effective in relieving constipation. However, although both treatment options can increase the frequency of defecations and the sensation of complete evacuation, the court type Thai traditional massage seems to be better since it leads to normal defecations rather than watery or entirely liquid defecations with no solid pieces (<i>p</i> < 0.05). This randomized controlled trial suggested that Thai traditional abdominal massage can be used as an optional public health treatment for constipation.</p>","PeriodicalId":15714,"journal":{"name":"Journal of Evidence-based Integrative Medicine","volume":"25 ","pages":"2515690X20960644"},"PeriodicalIF":3.5,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/2515690X20960644","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38434223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of Yoga and Meditation as Complimentary Therapeutic Regime for Stress-Related Neuropsychiatric Disorders: Utilization of Brain Waves Activity as Novel Tool.","authors":"Medha Kaushik, Akarshi Jain, Puneet Agarwal, Shiv Dutt Joshi, Suhel Parvez","doi":"10.1177/2515690X20949451","DOIUrl":"10.1177/2515690X20949451","url":null,"abstract":"<p><p>During recent decades, stress-related neuropsychiatric disorders such as anxiety, depression, chronic tension headache, and migraine have established their stronghold in the lives of a vast number of people worldwide. In order to address this global phenomenon, intensive studies have been carried out leading to the advancement of drugs like anti-depressants, anxiolytics, and analgesics which although help in combating the symptoms of such disorders but also create long-term side effects. Thus, as an alternative to such clinical practices, various complementary therapies such as yoga and meditation have been proved to be effective in alleviating the causes and symptoms of different neuropsychiatric disorders. The role of altered brain waves in this context has been recognized and needs to be pursued at the highest level. Thus, the current study provides a review focused on describing the effects of yoga and meditation on anxiety and depression as well as exploring brain waves as a tool for assessing the potential of these complementary therapies for such disorders.</p>","PeriodicalId":15714,"journal":{"name":"Journal of Evidence-based Integrative Medicine","volume":"25 ","pages":"2515690X20949451"},"PeriodicalIF":3.5,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/2515690X20949451","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38430657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of an Expert Guided Integrative Therapy Concept in Patients With Breast or Gynecological Cancer During Systemic Therapy.","authors":"Georg Schmidt,&nbsp;Sofia Mathes,&nbsp;Evelyn Klein,&nbsp;Marion Kiechle,&nbsp;Daniela Paepke","doi":"10.1177/2515690X20949444","DOIUrl":"https://doi.org/10.1177/2515690X20949444","url":null,"abstract":"<p><strong>Purpose: </strong>Breast and gynecological cancer patients undergoing systemic therapy frequently request integrative therapy concepts. The potential of integrative therapy (IM) lies in minimizing side effects of conventional cancer treatments and therefore decreasing treatment delays. IM can help to improve patients' physical and emotional well-being, optimizing health and quality of life as IM involves patients in their own treatment. A counseling service for integrative medicine concepts as an outpatient program was implemented in our cancer center in 2013.</p><p><strong>Methods: </strong>In 2016 and 2017 144 breast and gynecological cancer patients were included into our specific IM program. The program comprises biological based complementary and alternative medicines (BB-CAM), a structured exercise therapy, manipulative and body-based practices, nutritional counseling, psycho-oncological and relaxing therapies. Therapists with additional specialization for IM, guide the treatment units. The program was evaluated via self-administered questionnaire.</p><p><strong>Results: </strong>78% of the participating patients noticed an improvement by using BB-CAMs. 86% stated to feel better through participation in the structured exercise program. 74% profited from nutritional counseling and 91% from manual therapy. 93% of the patients treated with body compresses considered the application as soothing. The Bio-Frequency Sound Color Bed led to a relaxation in 96%. Psychological therapy improved coping with the disease in 70% of the patients.</p><p><strong>Conclusion: </strong>Integrative oncology combines the best practices of conventional and complementary therapy, uniting them in a holistic concept. Data show that our integrative therapy concept is well accepted by the patients and that therapy- and disease-related side effects can be reduced.</p>","PeriodicalId":15714,"journal":{"name":"Journal of Evidence-based Integrative Medicine","volume":"25 ","pages":"2515690X20949444"},"PeriodicalIF":3.5,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/2515690X20949444","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38276379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Older Adult Caregivers' Experiences in an Online, Interactive Mindfulness Intervention.","authors":"Janella Hudson, Rachel Ungar, Laurie Albright, Rifky Tkatch, James Schaeffer, Ellen R Wicker","doi":"10.1177/2515690X20960659","DOIUrl":"10.1177/2515690X20960659","url":null,"abstract":"<p><strong>Background: </strong>While today's older adults experience longevity, they often manage several chronic conditions and increasingly serve as informal caregivers for aging parents, children with life-long disabilities, and spouses. Older adult caregivers managing personal chronic illness often experience significant psychosocial hardships.</p><p><strong>Objective: </strong>The primary purpose of this study was to explore the experiences of older adult caregivers in an online, interactive mindfulness intervention.</p><p><strong>Methods: </strong>Self-reported older caregivers who participated in an online-based mindfulness program (n = 20) were recruited for semi-structured interviews. Participants were asked to provide feedback about any previous experience with mindfulness and/or meditation, hopes or goals held prior to the start of the program, desired expectations, motivation for joining, impressions of sessions, most beneficial topics, potential application of content, and any perceived effects. Participants' responses were analyzed using qualitative content analysis.</p><p><strong>Results: </strong>Five themes emerged from the analysis: Managing the Comprehensive Effects of Caregiving, Openness to Meditation and Mindfulness, Course Engagement and Incremental Growth, Building Rapport through Shared Experiences, and Ongoing Application and Opportunities for Refinement. Participants reported both short-term post-exercise benefits such as increased calm, relaxation, and stress relief, as well as long-term positive outcomes. Notably, participants found the program's unique interactive feature to be particularly beneficial as a form of perceived social support.</p><p><strong>Conclusions: </strong>Caregivers for older adults may derive benefit and potentially experience reduced subjective caregiver burden as a result of participating in a Mindfulness-Based Stress Reduction (MBSR) program, particularly when the program is augmented with a self-compassion approach and perceived social support.</p>","PeriodicalId":15714,"journal":{"name":"Journal of Evidence-based Integrative Medicine","volume":"25 ","pages":"2515690X20960659"},"PeriodicalIF":3.5,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/1c/03/10.1177_2515690X20960659.PMC7573722.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38488323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In Vitro Antioxidant Properties of Dichloromethanolic Leaf Extract of Gnidia glauca (Fresen) as a Promising Antiobesity Drug","authors":"W. Arika, C. Kibiti, J. Njagi, M. Ngugi","doi":"10.1177/2515690X19883258","DOIUrl":"https://doi.org/10.1177/2515690X19883258","url":null,"abstract":"The acquisition of ethnobotanical information from traditional practitioners remains an empirical aspect of understanding the ethnopharmacology research. However, integration of information on chemical composition of plant extracts and their pharmacological activities forms a key resource for synthesis of new and effective therapeutics. In traditional African medicine, Gnidia glauca has folkloric remedies against obesity and its associated oxidative stress-mediated complications. However, the upsurge in its use has not been accompanied with scientific validations to support these claims. The present study aimed to determine the antioxidant potential of G glauca as a promising antiobesity agent. The antioxidant effects of the extract were assessed against 1,1-diphenyl-2-picrylhydrazyl, hydroxyl, hydrogen peroxide, nitric oxide, and superoxide radicals as well as lipid peroxidation, iron-chelating effect, and ferric-reducing power. Phytochemical analysis was conducted using gas chromatography linked to mass spectrophotometry. The results revealed that G glauca exhibited scavenging activities against all radicals formed. Besides, the extract showed iron chelation and ferric reducing abilities. The extract indicated a lower half maximal inhibitory concentration value than the standards used. For instance, the extract inhibited 50% of the formation of 2,2-diphenyl-1-picrylhydrazine at the concentration of 1.33 ± 0.03 mg/mL relative to 1.39 ± 0.06 mg/mL of the standard, vitamin C at 1% confidence limit. Similarly, the extract scavenged 50% of hydroxyl radical at 204.34 ± 10.64 μg/mL relative to 210.05 ± 8.80 μg/mL of gallic acid. The extract also contained various phytochemicals that have been associated with antiobesity effects. The synergistic effects of these phytocompounds increase their bioavailability and action on multiple molecular targets thereby correcting obesity-induced oxidative stress.","PeriodicalId":15714,"journal":{"name":"Journal of Evidence-based Integrative Medicine","volume":" ","pages":""},"PeriodicalIF":3.5,"publicationDate":"2019-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/2515690X19883258","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46701943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}