Journal of Evidence-based Integrative Medicine最新文献

{"title":"Laxative Activities of 80% Methanolic Extract of the Leaves of <i>Grewia ferruginea</i> Hochst Ex A Rich in Mice.","authors":"Mulusew Yemiru Tessema, Zewdu Birhanu Wubneh, Assefa Belay Asrie","doi":"10.1177/2515690X20926922","DOIUrl":"10.1177/2515690X20926922","url":null,"abstract":"<p><strong>Background: </strong>There are numerous medicinal plants including the leaves of <i>Grewia ferruginea</i> used as traditional medicine for the treatment of constipation. This study was conducted to evaluate the laxative activity of the leaves of <i>G ferruginea</i>.</p><p><strong>Methods: </strong>The laxative activity of the leaves of <i>G ferruginea</i> was tested using 3 models: laxative activity, gastrointestinal motility, and gastrointestinal secretion tests. The effect of the plant extract on mean number of feces, fecal water content, ratio of intestinal distance traveled by the charcoal meal and intestinal fluid accumulation were evaluated and analyzed.</p><p><strong>Results: </strong>Significant increase was observed in the mean weight of wet fecal matter at 200 (1.00 ± 0.03 g, <i>P</i> < .05) and 400 mg/kg (1.01 ± 0.02 g, <i>P</i> < .01), relative to loperamide constipated negative control group. Similarly, percent fecal water content was significantly improved in extract treated groups at 100 mg/kg (52.10% ± 2.04%, <i>P</i> < .05), 200 mg/kg (54.02% ± 2.15%, <i>P</i> < .01), and 400 mg/kg (54.25% ± 2.50%, <i>P</i> < .01) compared with the negative control group. The gastroinestinal transit ratio was also significantly increased with 200 mg/kg (<i>P</i> < .01) and 400 mg/kg (<i>P</i> < .001) of the extract relative to the constipated negative control. The crude extract showed significant increase in intestinal fluid accumulation at 200 mg/kg (0.48 ± 0.07 g, <i>P</i> < .05) and 400 mg/kg (0.51 ± 0.08 g, <i>P</i> < .01) compared with the negative control.</p><p><strong>Conclusion: </strong>The results of the present study indicated that 80% methanol extract of the leaves of <i>G ferruginea</i> possessed significant laxative activity. As such, this study corroborates the traditional claim of using <i>G ferruginea</i> in the treatment of constipation.</p>","PeriodicalId":15714,"journal":{"name":"Journal of Evidence-based Integrative Medicine","volume":null,"pages":null},"PeriodicalIF":3.3,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/e1/b7/10.1177_2515690X20926922.PMC7271677.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38005618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Valerian Root in Treating Sleep Problems and Associated Disorders-A Systematic Review and Meta-Analysis.","authors":"Noriko Shinjyo,&nbsp;Guy Waddell,&nbsp;Julia Green","doi":"10.1177/2515690X20967323","DOIUrl":"https://doi.org/10.1177/2515690X20967323","url":null,"abstract":"<p><p>Sleep problems are widely prevalent and associated with various comorbidities including anxiety. Valerian (<i>Valeriana officinalis</i> L.) is a popular herbal medicine used as a sleep aid, however the outcomes of previous clinical studies are inconsistent. This study was conducted to update and re-evaluate the available data in order to understand the reason behind the inconsistent outcomes and to provide a broader view of the use of valerian for associated disorders. PubMed, ScienceDirect, and Cochrane Library were searched to retrieve publications relevant to the effectiveness of valerian as a treatment of sleep problems and associated disorders. A total of 60 studies (n=6,894) were included in this review, and meta-analyses were performed to evaluate the effectiveness to improve subjective sleep quality (10 studies, n=1,065) and to reduce anxiety (8 studies, n=535). Results suggested that inconsistent outcomes were possibly due to the variable quality of herbal extracts and that more reliable effects could be expected from the whole root/rhizome. In addition, therapeutic benefits could be optimized when it was combined with appropriate herbal partners. There were no severe adverse events associated with valerian intake in subjects aged between 7 and 80 years. In conclusion, valerian could be a safe and effective herb to promote sleep and prevent associated disorders. However, due to the presence of multiple active constituents and relatively unstable nature of some of the active constituents, it may be necessary to revise the quality control processes, including standardization methods and shelf life.</p>","PeriodicalId":15714,"journal":{"name":"Journal of Evidence-based Integrative Medicine","volume":null,"pages":null},"PeriodicalIF":3.5,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/2515690X20967323","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38610605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nutritional and Functional Properties of Wild Food-Medicine Plants From the Coastal Region of South China.","authors":"Yuan Xu, Dan Liang, Gang-Tao Wang, Jun Wen, Rui-Jiang Wang","doi":"10.1177/2515690X20913267","DOIUrl":"10.1177/2515690X20913267","url":null,"abstract":"<p><p>Food-medicine plants play an important role in providing nutrition and treating chronic diseases, especially in many minority communities and developing regions. The coastal region of South China has abundant resources of medicinal plants. A long history of cross-cultural medicinal practices among different minority groups has facilitated the development of a remarkable dietary culture by using food-medicine plants. However, integrative ethnobotanical research on both nutritional and functional properties of the food-medicine plants in this region is still limited. In this study, 27 commonly used wild food-medicine plants were recorded and analyzed from the coastal region of South China. Most of them are good sources for calcium (47.83-1099.89 mg/100 g fresh weight), dietary fiber (3.00-31.87 mg/100 g fresh weight), iron (1.17-24.73 mg/100 g fresh weight), and vitamin C (0.44-68.32 mg/100 g fresh weight). <i>Solanum americanum</i> has the highest average nutritive value and is also considered to be good sources for proteins (7.90 g/100 g fresh weight). Medicinal properties of the studied species can be classified into 8 categories: treatment of the damp-heat syndrome, digestive diseases, urologic diseases, arthropathy, respiratory diseases, gynecological diseases, snake or insect bites, and uses as a tonic. Treating the damp-heat syndrome or expelling warm pathogenic factors is the most commonly used ethnomedicinal practice in the study area. The present study highlights that the local ethnomedicinal practices are deeply influenced by local natural conditions and customs. Food-medicine plants with superior key nutrients have been used regularly in the diet as medicinal food to alleviate common endemic diseases.</p>","PeriodicalId":15714,"journal":{"name":"Journal of Evidence-based Integrative Medicine","volume":null,"pages":null},"PeriodicalIF":3.5,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/2515690X20913267","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37839584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Gene-Eden-VIR and Novirin on SARS-CoV: Implications for COVID-19.","authors":"Hanan Polansky,&nbsp;Gillad Lori","doi":"10.1177/2515690X20932523","DOIUrl":"https://doi.org/10.1177/2515690X20932523","url":null,"abstract":"<p><p>The coronavirus (SARS-CoV-2), which causes COVID-19, is a betacoronavirus closely related to the human severe acute respiratory syndrome (SARS)-coronavirus (SARS-CoV). The recent COVID-19 outbreak created an urgent need for treatment. To expedite the development of such treatment, pharmaceutical companies and government agencies are currently testing several existing drugs for their effect on the virus. Gene-Eden-VIR and Novirin are natural, broad-spectrum, antiviral treatments proven to be safe and effective in several clinical studies. In this article, we present evidence indicating that the 5 Gene-Eden-VIR/Novirin ingredients have anti-betacoronavirus, and specifically, anti-SARS-CoV effects. We consider this evidence as a first indication of the anti-coronavirus effects of Gene-Eden-VIR/Novirin. Next, we are planning to conduct a clinical study with users of the treatments to test the effects of Gene-Eden-VIR/Novirin on individuals at risk and those infected with the virus.</p>","PeriodicalId":15714,"journal":{"name":"Journal of Evidence-based Integrative Medicine","volume":null,"pages":null},"PeriodicalIF":3.5,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/2515690X20932523","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38055508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Antimalarial Activity of Methanolic Root Extract of <i>Myrica salicifolia</i> A Rich (Myricaceae) Against <i>Plasmodium berghei</i>-Infected Mice.","authors":"Zemene Demelash Kifle, Getnet Mequanint Adinew, Mestayet Geta Mengistie, Abyot Endale Gurmu, Engidaw Fentahun Enyew, Bahiru Tenaw Goshu, Gedefaw Getenet Amare","doi":"10.1177/2515690X20920539","DOIUrl":"10.1177/2515690X20920539","url":null,"abstract":"<p><strong>Background: </strong>The management and control of malaria has become gradually challenging due to the spread of drug-resistant parasites, lack of effective vaccine, and the resistance of vector to insecticides. Consequently, novel agents are urgently needed from different sources including from medicinal plants. In Ethiopia and Uganda, <i>Myrica salicifolia</i> root is traditionally claimed for the treatment of malaria. The aim of this study was to evaluate the in vivo antimalarial activity of root crude extract of <i>M salicifolia</i>.</p><p><strong>Methods: </strong>The parasite, <i>Plasmodium berghei</i> was used in this study since it is an appropriate parasite that is most commonly used because of its higher accessibility. A 4-day suppressive test was employed to evaluate the antimalarial effect of crude extract against early infection. The curative and prophylactic effect of the crude extract was further tested by Rane's test and residual infection procedure. Parasitemia, survival time, packed cell volume, body weight, and rectal temperature of mice were used as evaluation parameters. Windows SPSS version 24 was used to analyze the data and analysis of variance followed by Tukey's honestly significant difference to compare results between groups.</p><p><strong>Results: </strong>The root crude extract of <i>M salicifolia</i> significantly (<i>P</i> < .05-.0001) suppressed parasitemia. The crude extract exhibited a chemosuppression of 40.90.</p><p><strong>Conclusion: </strong>The development of new antimalarial agents and the finding supports the traditional claims and previous in vitro studies.</p>","PeriodicalId":15714,"journal":{"name":"Journal of Evidence-based Integrative Medicine","volume":null,"pages":null},"PeriodicalIF":3.5,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/22/67/10.1177_2515690X20920539.PMC7180309.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37860316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Assay on the Possible Effect of Essential Oil Constituents on Receptors Involved in Women's Hormonal Health and Reproductive System Diseases.","authors":"Amirhossein Sakhteman,&nbsp;Ardalan Pasdaran,&nbsp;Mehdi Afifi,&nbsp;Azadeh Hamedi","doi":"10.1177/2515690X20932527","DOIUrl":"https://doi.org/10.1177/2515690X20932527","url":null,"abstract":"<p><p>Aromatic herbal remedies, hydrosols, and essential oils are widely used for women's hormonal health. Scientific investigation of their major constituents may prevent unwanted infertility cases, fetal abnormalities, and drug-herb interactions. It also may lead to development of new medications. A list of 265 volatile molecules (mainly monoterpenes and sesquiterpenes) were prepared from a literature survey in Scopus and PubMed (2000-2019) on hydrosols and essential oils that are used for women's hormonal and reproductive health conditions. The PDB (protein data bank) files of the receptors (136 native PDB files) that involve with oxytocin, progesterone, estrogen, prolactin, acetyl choline, androgen, dopamine, human chorionic gonadotropin, luteinizing hormone, follicle-stimulating hormone, aromatase, and HER2 receptors were downloaded from Protein Data Bank. An in silico study using AutoDock 4.2 and Vina in parallel mode was performed to investigate possible interactions of the ligands with the receptors. Drug likeliness was investigated for the most active molecules using DruLiTo software. Aristola-1(10),8-diene, bergapten (5-methoxypsoralen), α-bergamotene, bicyclogermacrene, α-bisabolol oxide A, α-bisabolone oxide, <i>p</i>-cymen-8-ol, 10-epi elemol, α-elemol, β-eudesmol, 7-<i>epi</i>-β-eudesmol, ficusin, β-humulene, methyl jasmonate, nerolidol, pinocarvone, (+)-spathulenol, and thujone had better interactions with some androgen, aromatase, estrogen, progesterone, HER2, AChR, and/or dopamine receptors. Most of these molecules had an acceptable drug likeliness except for α-bergamotene, bicyclogermacrene, β-humulene, and aristola-1(10),8-diene. Some volatile natural molecules can be considered as lead compound for drug development to treat hormonal conditions.</p>","PeriodicalId":15714,"journal":{"name":"Journal of Evidence-based Integrative Medicine","volume":null,"pages":null},"PeriodicalIF":3.5,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/2515690X20932527","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38071346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"WITHDRAWAL - Administrative Duplicate Publication: Complementary Therapies as a Strategy to Reduce Stress and Stimulate Immunity of Women With Breast Cancer.","authors":"","doi":"10.1177/2515690X19889145","DOIUrl":"https://doi.org/10.1177/2515690X19889145","url":null,"abstract":"Understanding the effect of domestic macroeconomic forces on equity market is essential since macroeconomic forces have a systematic effect on the equity market returns. The present study uses monthly observations from India for the period from January 2012 to December 2019 to investigate the long-run and short-run relationship between the domestic macroeconomic forces and equity market. The study employed the autoregressive distributed lag (ARDL) bounds testing approach and pair-wise granger causality test to attain the objective. The long-run empirical results indicated that the Indian equity market and the domestic macroeconomic forces are cointegrated. The long-run coefficients of foreign exchange rate and money supply are found to be significant. The short-run coefficients suggest that money supply, inflation and foreign exchange rate significantly influence the Indian equity market. The study also observed the presence of feedback mechanism between foreign exchange rate and Indian equity market. The study provides the policy and managerial implications.","PeriodicalId":15714,"journal":{"name":"Journal of Evidence-based Integrative Medicine","volume":null,"pages":null},"PeriodicalIF":3.5,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/2515690X19889145","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37601175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In Vitro Antioxidant Activities of the Aqueous and Methanolic Stem Bark Extracts of <i>Piliostigma thonningii</i> (Schum.).","authors":"Gervason Moriasi, Anthony Ireri, Mathew Piero Ngugi","doi":"10.1177/2515690X20937988","DOIUrl":"10.1177/2515690X20937988","url":null,"abstract":"<p><p>Oxidative stress has been recognized as a key driver of many ailments affecting humankind. Free radicals attack biologically important biomolecules, impairing their functioning, thereby initiating and exacerbating diseases. As a comeback, antioxidant therapies have been proposed as novel approaches to ameliorating oxidative stress-associated diseases including chronic ones. Antioxidants are thought to employ multifaceted and multitargeted mechanisms that either restore oxidative homeostasis or prevent free radical buildup in the body, which overwhelm the endogenous defenses. Plants have been used for many ages across time to manage human diseases, and have a host of antioxidant phytocompounds. <i>Piliostigma thonningii</i> is traditionally used for the management of inflammation, malaria fever, rheumatism, and insanity, among other diseases caused by a disturbed redox state in the body. In this study, <i>in vitro</i> antioxidant activities of the methanolic and aqueous stem bark extracts of <i>P. thonningii</i> were evaluated using the <i>in vitro</i> antilipid peroxidation, the 1,1-diphenyl-2-picryhydrazyl (DPPH) free radical scavenging, and the ferric reducing antioxidant power assay methods. The obtained results revealed remarkable antioxidant activities of the studied plant extracts as evidenced by the low IC₅₀ and EC₅₀ values. These antioxidant activities could be due to the presence of antioxidant phytochemicals like flavonoids, carotenoids, tannins, and phenols, among others. Therefore, the therapeutic potency of this plant could be due to its antioxidant properties. This study recommends <i>in vivo</i> antioxidant efficacy testing of the studied plant extracts, as well as isolation and characterization of bioactive antioxidant compounds that are potent against oxidative stress.</p>","PeriodicalId":15714,"journal":{"name":"Journal of Evidence-based Integrative Medicine","volume":null,"pages":null},"PeriodicalIF":3.3,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/9a/ae/10.1177_2515690X20937988.PMC7364801.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38159602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ethnobotany of Medicinal Plants Used by Rakhine Indigenous Communities in Patuakhali and Barguna District of Southern Bangladesh.","authors":"A T M Rafiqul Islam,&nbsp;Mahadiy Hasan,&nbsp;Tahidul Islam,&nbsp;Ashikur Rahman,&nbsp;Shawon Mitra,&nbsp;Subroto K Das","doi":"10.1177/2515690X20971586","DOIUrl":"https://doi.org/10.1177/2515690X20971586","url":null,"abstract":"<p><p>An extensive study has been made to identify, document, and investigate the ethnomedicinal plants used by Rakhine ethnic minorities in Patuakhali and Barguna District of southern Bangladesh for the term of April 2018 to June 2019. In this article, we have focused on the Rakhine population trends, management concerns, and some actions for conserving the Rakhine population diversity in the study area. In this study, we have identified the locations where Rakhine population lives in Patuakhali and Barguna districts. A total of 86 plant species belonging to 71 genera and 43 families were reported to be used for treating more than 57 various physical ailments under 14 illness categories from the study area. For each of the species, the botanic name, common name, Rakhine name, family, habit, parts used and traditional medicinal uses of the plant species have been presented. The maximum numbers of ethnomedicinal plant species were utilized to treat gastrointestinal complaints (43) taken after by the treatment of dermatological issues (36). The highly cited (75.60%) plant species were found to be <i>Ananas comosus</i> and <i>Aegle marmelos</i> used for gastro-intestinal (Stomach pain, indigestion, and dysentery) digestive disorders and subsequently followed by <i>Colocasia esculenta</i> (70.73%) used for cut, bleeding and wound healing. The results of this study have shown that Rakhine indigenous communities still depend on conventional plant-based medication to remedy various diseases and therapeutic purposes in the study area. Our findings have also shown that despite there have adequate phytodiversity in the natural habitat of the study area but the number of Rakhine population has been declining significantly day-by-day. As an ultimate result, we have lost the plant-based traditional medicinal knowledge of Rakhine indigenous communities in Bangladesh. As a rich source of traditional knowledge and cultural diversity, it calls for urgent initiatives to conserve the cultural heritage of the Rakhine community as well as the diversity of Rakhine ethnic group.</p>","PeriodicalId":15714,"journal":{"name":"Journal of Evidence-based Integrative Medicine","volume":null,"pages":null},"PeriodicalIF":3.5,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/2515690X20971586","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38746273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigation of the In Vitro Antioxidant Potential Of Polyphenolic-Rich Extract of <i>Artocarpus heterophyllus</i> Lam Stem Bark and Its Antidiabetic Activity In Streptozotocin-Induced Diabetic Rats.","authors":"Basiru Olaitan Ajiboye,&nbsp;Oluwafemi Adeleke Ojo,&nbsp;Babatunji Emmanuel Oyinloye,&nbsp;Mary Abiola Okesola,&nbsp;Adeyonu Oluwatosin,&nbsp;Aline Augusti Boligon,&nbsp;Abidemi Paul Kappo","doi":"10.1177/2515690X20916123","DOIUrl":"https://doi.org/10.1177/2515690X20916123","url":null,"abstract":"<p><p><i>Artocarpus heterophyllus</i> Lam (Moraceae) stem bark has been used locally in managing diabetes mellitus with sparse scientific information. This study investigates the in vitro antioxidant potential of polyphenolic-rich extract of <i>A heterophyllus</i> stem bark as well as its antidiabetic activity in streptozotocin-induced diabetic rats. Fifty male Wistar rats were used with the induction of diabetes by a single intraperitoneal injection of streptozotocin (45 mg/kg body weight) and were orally administered 400 mg/kg free and bound phenols of <i>A heterophyllus</i> stem bark. The animals were sacrificed on the 28th day of the experiment using the cervical dislocation method; antihyperglycemia and anti-inflammatory parameters were subsequently assessed. The polyphenolic extracts demonstrated antioxidant potentials (such as hydrogen peroxide and diphenyl-1-picrylhydrazyl), as well as strong inhibitory activity against amylase and glucosidase. There was a significant (<i>P</i> < .05) increase in glycogen, insulin concentration, pancreatic β-cell scores (HOMA-β), antioxidant enzymes and hexokinase activities, as well as glucose transporter concentration in diabetic animals administered the extracts and metformin. Also, a significant (<i>P</i> < .05) reduction in fasting blood glucose, lipid peroxidation, glucose-6-phosphatase, and all anti-inflammatory parameters were observed in diabetic rats administered the extracts and metformin. The extracts demonstrated antidiabetic potential, which may be useful in the management of diabetes mellitus.</p>","PeriodicalId":15714,"journal":{"name":"Journal of Evidence-based Integrative Medicine","volume":null,"pages":null},"PeriodicalIF":3.5,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/2515690X20916123","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37950293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}