Journal of Evidence-based Integrative Medicine最新文献_第9页

Modulation of Oxidative Stress and Inflammatory Cytokines as Therapeutic Mechanisms of Ocimum americanum L Extract in Carbon Tetrachloride and Acetaminophen-Induced Toxicity in Rats. 欧鼠李提取物在四氯化碳和对乙酰氨基酚诱导的大鼠毒性中调节氧化应激和炎性细胞因子的治疗机制

IF 3.5

Journal of Evidence-based Integrative Medicine Pub Date : 2020-01-01 DOI: 10.1177/2515690X20938002

Afua Kobi Ampem Genfi, Christopher Larbie, Benjamin O Emikpe, Ademola A Oyagbemi, Caleb K Firempong, Clement O Adjei

{"title":"Modulation of Oxidative Stress and Inflammatory Cytokines as Therapeutic Mechanisms of Ocimum americanum L Extract in Carbon Tetrachloride and Acetaminophen-Induced Toxicity in Rats.","authors":"Afua Kobi Ampem Genfi, Christopher Larbie, Benjamin O Emikpe, Ademola A Oyagbemi, Caleb K Firempong, Clement O Adjei","doi":"10.1177/2515690X20938002","DOIUrl":"10.1177/2515690X20938002","url":null,"abstract":"Liver diseases have now become a global canker due to increasing drug abuse and several viral infections. The current medicines on the market are woefully inadequate and limited in the application against these diseases. Fortunately, medicinal plants continue to serve as a potential source of drug discovery that could be explored to improve the situation. The present study, therefore, evaluated the hepatoprotective activities of the aqueous extract of various parts (leaves, flower and stem) of Ocimum americanum L on carbon tetrachloride (CCl4)- and acetaminophen-induced toxicity in rats. The protective effect of the plant was assessed using biochemical parameters, histology, levels of liver antioxidants, and expression of some pro-inflammatory cytokines (NF-κβ and IL-1) in the liver. The leaves and stem extracts, orally administered for 7 days at 250 mg/kg, effectively prevented CCl4-induced elevation of serum biochemical parameters, prooxidants, as well as the expression of NFk-B and IL-1, which were comparable to Silymarin (standard drug). A comparative histopathological analyses of the liver exhibited virtually normal architecture compared with CCl4-treated group. The findings showed that the hepatoprotective effect of Ocimum americanum was probably due to the inhibition of oxidative stress and downregulation of proinflammatory cytokines by the effective parts of the medicinal plant.","PeriodicalId":15714,"journal":{"name":"Journal of Evidence-based Integrative Medicine","volume":"25 ","pages":"2515690X20938002"},"PeriodicalIF":3.5,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/d1/cb/10.1177_2515690X20938002.PMC7520933.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38508500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dysfunction of the Microbiota-Gut-Brain Axis in Neurodegenerative Disease: The Promise of Therapeutic Modulation With Prebiotics, Medicinal Herbs, Probiotics, and Synbiotics. 神经退行性疾病中的微生物群-肠-脑轴功能失调：用益生元、药草、益生菌和合成益生菌进行治疗调节的前景。

IF 3.5

Journal of Evidence-based Integrative Medicine Pub Date : 2020-01-01 DOI: 10.1177/2515690X20957225

Christine Tara Peterson

{"title":"Dysfunction of the Microbiota-Gut-Brain Axis in Neurodegenerative Disease: The Promise of Therapeutic Modulation With Prebiotics, Medicinal Herbs, Probiotics, and Synbiotics.","authors":"Christine Tara Peterson","doi":"10.1177/2515690X20957225","DOIUrl":"10.1177/2515690X20957225","url":null,"abstract":"Recent data suggest gut microbiota dysbiosis as a contributing factor in neurodegenerative diseases, such as Parkinson's Disease (PD) and Alzheimer's Disease (AD), and these pathologies may manifest via the microbiota-gut-brain-axis, which comprises bidirectional communication through neuroimmune, neuroendocrine, and direct neural pathways such as the vagus nerve. Preclinical and human clinical trial data reveal exciting potential for novel treatment targets and therapeutic modulation with prebiotics, medicinal herbs, probiotics, and synbiotics in health, aging, and neurodegeneration and are reviewed here. While greater insights and characterization of the microbiota-gut-brain axis have been revealed over the past decade, salient questions related to the pathology, pathogenesis and clinical treatment of the axis in the context of both health and neurodegenerative disease remain and are discussed in this review. Future directions such as additional well-controlled, large scale, longitudinal human clinical trials are urgently needed to further elucidate both mechanism and therapeutic opportunity in health, neurological disease, and disease subpopulations to ensure that the next decade ushers the dawn of targeted therapeutic modulation of the microbiota-gut-brain axis.","PeriodicalId":15714,"journal":{"name":"Journal of Evidence-based Integrative Medicine","volume":"25 ","pages":"2515690X20957225"},"PeriodicalIF":3.5,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/8f/0c/10.1177_2515690X20957225.PMC7586271.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38519074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In Vitro and In Vivo Antimalarial Activities and Toxicological Assessment of Pogostemon Cablin (Blanco) Benth. 广藿香的体内外抗疟活性及毒理学评价。

IF 3.5

Journal of Evidence-based Integrative Medicine Pub Date : 2020-01-01 DOI: 10.1177/2515690X20978387

Arisara Phuwajaroanpong, Prapaporn Chaniad, Natharinee Horata, Saowanee Muangchanburee, Kantarakorn Kaewdana, Chuchard Punsawad

{"title":"In Vitro and In Vivo Antimalarial Activities and Toxicological Assessment of Pogostemon Cablin (Blanco) Benth.","authors":"Arisara Phuwajaroanpong, Prapaporn Chaniad, Natharinee Horata, Saowanee Muangchanburee, Kantarakorn Kaewdana, Chuchard Punsawad","doi":"10.1177/2515690X20978387","DOIUrl":"https://doi.org/10.1177/2515690X20978387","url":null,"abstract":"The aim of this study was to investigate the antimalarial activities and toxicity of Pogostemon cablin extracts. In vitro activities against the chloroquine-resistant Plasmodium falciparum K1 strain were assessed by using the Plasmodium lactate dehydrogenase enzyme (pLDH) assay, while in vivo activity against the Plasmodium berghei ANKA strain in mice was investigated using a 4-day suppressive test. The in vitro and in vivo toxicity were determined in Vero cells and mice, respectively. The ethanolic extract possessed antimalarial activity with an IC50 of 24.49 ± 0.01 µg/ml, whereas the aqueous extract showed an IC50 of 549.30 ± 0.07 µg/ml. Cytotoxic analyses of the ethanolic and aqueous extracts revealed a nontoxic effect on Vero cells at a concentration of 80 µg/ml. Based on a preliminary study of in vitro antimalarial activity, the ethanolic extract was chosen as a potential agent for further in vivo antimalarial activity analysis in mice. The ethanolic extract, which showed no toxic effect on mice at a dose of 2000 mg/kg body weight, significantly suppressed parasitemia in mice by 38.41%, 45.12% and 89.00% at doses of 200, 400 and 600 mg/kg body weight, respectively. In conclusion, this study shows that the ethanolic P. cablin extract possesses in vitro and in vivo antimalarial activity without toxic effects.","PeriodicalId":15714,"journal":{"name":"Journal of Evidence-based Integrative Medicine","volume":"25 ","pages":"2515690X20978387"},"PeriodicalIF":3.5,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/2515690X20978387","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38708652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 13

Laxative Activities of 80% Methanolic Extract of the Leaves of Grewia ferruginea Hochst Ex A Rich in Mice. Grewia ferruginea Hochst Ex A Rich 叶子 80% 甲醇提取物对小鼠的泻药活性。

IF 3.3

Journal of Evidence-based Integrative Medicine Pub Date : 2020-01-01 DOI: 10.1177/2515690X20926922

Mulusew Yemiru Tessema, Zewdu Birhanu Wubneh, Assefa Belay Asrie

{"title":"Laxative Activities of 80% Methanolic Extract of the Leaves of Grewia ferruginea Hochst Ex A Rich in Mice.","authors":"Mulusew Yemiru Tessema, Zewdu Birhanu Wubneh, Assefa Belay Asrie","doi":"10.1177/2515690X20926922","DOIUrl":"10.1177/2515690X20926922","url":null,"abstract":"Background: There are numerous medicinal plants including the leaves of Grewia ferruginea used as traditional medicine for the treatment of constipation. This study was conducted to evaluate the laxative activity of the leaves of G ferruginea.Methods: The laxative activity of the leaves of G ferruginea was tested using 3 models: laxative activity, gastrointestinal motility, and gastrointestinal secretion tests. The effect of the plant extract on mean number of feces, fecal water content, ratio of intestinal distance traveled by the charcoal meal and intestinal fluid accumulation were evaluated and analyzed.Results: Significant increase was observed in the mean weight of wet fecal matter at 200 (1.00 ± 0.03 g, P < .05) and 400 mg/kg (1.01 ± 0.02 g, P < .01), relative to loperamide constipated negative control group. Similarly, percent fecal water content was significantly improved in extract treated groups at 100 mg/kg (52.10% ± 2.04%, P < .05), 200 mg/kg (54.02% ± 2.15%, P < .01), and 400 mg/kg (54.25% ± 2.50%, P < .01) compared with the negative control group. The gastroinestinal transit ratio was also significantly increased with 200 mg/kg (P < .01) and 400 mg/kg (P < .001) of the extract relative to the constipated negative control. The crude extract showed significant increase in intestinal fluid accumulation at 200 mg/kg (0.48 ± 0.07 g, P < .05) and 400 mg/kg (0.51 ± 0.08 g, P < .01) compared with the negative control.Conclusion: The results of the present study indicated that 80% methanol extract of the leaves of G ferruginea possessed significant laxative activity. As such, this study corroborates the traditional claim of using G ferruginea in the treatment of constipation.","PeriodicalId":15714,"journal":{"name":"Journal of Evidence-based Integrative Medicine","volume":"25 ","pages":"2515690X20926922"},"PeriodicalIF":3.3,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/e1/b7/10.1177_2515690X20926922.PMC7271677.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38005618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Valerian Root in Treating Sleep Problems and Associated Disorders-A Systematic Review and Meta-Analysis. 缬草治疗睡眠问题及相关障碍的系统综述和荟萃分析。

IF 3.5

Journal of Evidence-based Integrative Medicine Pub Date : 2020-01-01 DOI: 10.1177/2515690X20967323

Noriko Shinjyo, Guy Waddell, Julia Green

{"title":"Valerian Root in Treating Sleep Problems and Associated Disorders-A Systematic Review and Meta-Analysis.","authors":"Noriko Shinjyo, Guy Waddell, Julia Green","doi":"10.1177/2515690X20967323","DOIUrl":"https://doi.org/10.1177/2515690X20967323","url":null,"abstract":"Sleep problems are widely prevalent and associated with various comorbidities including anxiety. Valerian (Valeriana officinalis L.) is a popular herbal medicine used as a sleep aid, however the outcomes of previous clinical studies are inconsistent. This study was conducted to update and re-evaluate the available data in order to understand the reason behind the inconsistent outcomes and to provide a broader view of the use of valerian for associated disorders. PubMed, ScienceDirect, and Cochrane Library were searched to retrieve publications relevant to the effectiveness of valerian as a treatment of sleep problems and associated disorders. A total of 60 studies (n=6,894) were included in this review, and meta-analyses were performed to evaluate the effectiveness to improve subjective sleep quality (10 studies, n=1,065) and to reduce anxiety (8 studies, n=535). Results suggested that inconsistent outcomes were possibly due to the variable quality of herbal extracts and that more reliable effects could be expected from the whole root/rhizome. In addition, therapeutic benefits could be optimized when it was combined with appropriate herbal partners. There were no severe adverse events associated with valerian intake in subjects aged between 7 and 80 years. In conclusion, valerian could be a safe and effective herb to promote sleep and prevent associated disorders. However, due to the presence of multiple active constituents and relatively unstable nature of some of the active constituents, it may be necessary to revise the quality control processes, including standardization methods and shelf life.","PeriodicalId":15714,"journal":{"name":"Journal of Evidence-based Integrative Medicine","volume":"25 ","pages":"2515690X20967323"},"PeriodicalIF":3.5,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/2515690X20967323","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38610605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 43

Effects of Gene-Eden-VIR and Novirin on SARS-CoV: Implications for COVID-19. Gene-Eden-VIR和Novirin对SARS-CoV的作用:对COVID-19的影响

IF 3.5

Journal of Evidence-based Integrative Medicine Pub Date : 2020-01-01 DOI: 10.1177/2515690X20932523

Hanan Polansky, Gillad Lori

引用次数: 1

Nutritional and Functional Properties of Wild Food-Medicine Plants From the Coastal Region of South China. 华南沿海野生食药植物的营养和功能特性。

IF 3.5

Journal of Evidence-based Integrative Medicine Pub Date : 2020-01-01 DOI: 10.1177/2515690X20913267

Yuan Xu, Dan Liang, Gang-Tao Wang, Jun Wen, Rui-Jiang Wang

{"title":"Nutritional and Functional Properties of Wild Food-Medicine Plants From the Coastal Region of South China.","authors":"Yuan Xu, Dan Liang, Gang-Tao Wang, Jun Wen, Rui-Jiang Wang","doi":"10.1177/2515690X20913267","DOIUrl":"10.1177/2515690X20913267","url":null,"abstract":"Food-medicine plants play an important role in providing nutrition and treating chronic diseases, especially in many minority communities and developing regions. The coastal region of South China has abundant resources of medicinal plants. A long history of cross-cultural medicinal practices among different minority groups has facilitated the development of a remarkable dietary culture by using food-medicine plants. However, integrative ethnobotanical research on both nutritional and functional properties of the food-medicine plants in this region is still limited. In this study, 27 commonly used wild food-medicine plants were recorded and analyzed from the coastal region of South China. Most of them are good sources for calcium (47.83-1099.89 mg/100 g fresh weight), dietary fiber (3.00-31.87 mg/100 g fresh weight), iron (1.17-24.73 mg/100 g fresh weight), and vitamin C (0.44-68.32 mg/100 g fresh weight). Solanum americanum has the highest average nutritive value and is also considered to be good sources for proteins (7.90 g/100 g fresh weight). Medicinal properties of the studied species can be classified into 8 categories: treatment of the damp-heat syndrome, digestive diseases, urologic diseases, arthropathy, respiratory diseases, gynecological diseases, snake or insect bites, and uses as a tonic. Treating the damp-heat syndrome or expelling warm pathogenic factors is the most commonly used ethnomedicinal practice in the study area. The present study highlights that the local ethnomedicinal practices are deeply influenced by local natural conditions and customs. Food-medicine plants with superior key nutrients have been used regularly in the diet as medicinal food to alleviate common endemic diseases.","PeriodicalId":15714,"journal":{"name":"Journal of Evidence-based Integrative Medicine","volume":"25 ","pages":"2515690X20913267"},"PeriodicalIF":3.5,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/2515690X20913267","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37839584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Evaluation of Antimalarial Activity of Methanolic Root Extract of Myrica salicifolia A Rich (Myricaceae) Against Plasmodium berghei-Infected Mice. 评估 Myrica salicifolia A Rich（Myricaceae）甲醇根提取物对受疟原虫感染的小鼠的抗疟活性。

IF 3.5

Journal of Evidence-based Integrative Medicine Pub Date : 2020-01-01 DOI: 10.1177/2515690X20920539

Zemene Demelash Kifle, Getnet Mequanint Adinew, Mestayet Geta Mengistie, Abyot Endale Gurmu, Engidaw Fentahun Enyew, Bahiru Tenaw Goshu, Gedefaw Getenet Amare

{"title":"Evaluation of Antimalarial Activity of Methanolic Root Extract of Myrica salicifolia A Rich (Myricaceae) Against Plasmodium berghei-Infected Mice.","authors":"Zemene Demelash Kifle, Getnet Mequanint Adinew, Mestayet Geta Mengistie, Abyot Endale Gurmu, Engidaw Fentahun Enyew, Bahiru Tenaw Goshu, Gedefaw Getenet Amare","doi":"10.1177/2515690X20920539","DOIUrl":"10.1177/2515690X20920539","url":null,"abstract":"Background: The management and control of malaria has become gradually challenging due to the spread of drug-resistant parasites, lack of effective vaccine, and the resistance of vector to insecticides. Consequently, novel agents are urgently needed from different sources including from medicinal plants. In Ethiopia and Uganda, Myrica salicifolia root is traditionally claimed for the treatment of malaria. The aim of this study was to evaluate the in vivo antimalarial activity of root crude extract of M salicifolia.Methods: The parasite, Plasmodium berghei was used in this study since it is an appropriate parasite that is most commonly used because of its higher accessibility. A 4-day suppressive test was employed to evaluate the antimalarial effect of crude extract against early infection. The curative and prophylactic effect of the crude extract was further tested by Rane's test and residual infection procedure. Parasitemia, survival time, packed cell volume, body weight, and rectal temperature of mice were used as evaluation parameters. Windows SPSS version 24 was used to analyze the data and analysis of variance followed by Tukey's honestly significant difference to compare results between groups.Results: The root crude extract of M salicifolia significantly (P < .05-.0001) suppressed parasitemia. The crude extract exhibited a chemosuppression of 40.90.Conclusion: The development of new antimalarial agents and the finding supports the traditional claims and previous in vitro studies.","PeriodicalId":15714,"journal":{"name":"Journal of Evidence-based Integrative Medicine","volume":"25 ","pages":"2515690X20920539"},"PeriodicalIF":3.5,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/22/67/10.1177_2515690X20920539.PMC7180309.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37860316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

WITHDRAWAL - Administrative Duplicate Publication: Complementary Therapies as a Strategy to Reduce Stress and Stimulate Immunity of Women With Breast Cancer. 撤销-行政复本出版物:补充疗法作为一种策略，以减轻压力和刺激免疫的妇女乳腺癌。

IF 3.5

Journal of Evidence-based Integrative Medicine Pub Date : 2020-01-01 DOI: 10.1177/2515690X19889145

{"title":"WITHDRAWAL - Administrative Duplicate Publication: Complementary Therapies as a Strategy to Reduce Stress and Stimulate Immunity of Women With Breast Cancer.","authors":"","doi":"10.1177/2515690X19889145","DOIUrl":"https://doi.org/10.1177/2515690X19889145","url":null,"abstract":"Understanding the effect of domestic macroeconomic forces on equity market is essential since macroeconomic forces have a systematic effect on the equity market returns. The present study uses monthly observations from India for the period from January 2012 to December 2019 to investigate the long-run and short-run relationship between the domestic macroeconomic forces and equity market. The study employed the autoregressive distributed lag (ARDL) bounds testing approach and pair-wise granger causality test to attain the objective. The long-run empirical results indicated that the Indian equity market and the domestic macroeconomic forces are cointegrated. The long-run coefficients of foreign exchange rate and money supply are found to be significant. The short-run coefficients suggest that money supply, inflation and foreign exchange rate significantly influence the Indian equity market. The study also observed the presence of feedback mechanism between foreign exchange rate and Indian equity market. The study provides the policy and managerial implications.","PeriodicalId":15714,"journal":{"name":"Journal of Evidence-based Integrative Medicine","volume":"25 ","pages":"2515690X19889145"},"PeriodicalIF":3.5,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/2515690X19889145","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37601175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

In Vitro Antioxidant Activities of the Aqueous and Methanolic Stem Bark Extracts of Piliostigma thonningii (Schum.). Piliostigma thonningii（Schum.）茎皮水提取物和甲醇提取物的体外抗氧化活性。

IF 3.3

Journal of Evidence-based Integrative Medicine Pub Date : 2020-01-01 DOI: 10.1177/2515690X20937988

Gervason Moriasi, Anthony Ireri, Mathew Piero Ngugi

{"title":"In Vitro Antioxidant Activities of the Aqueous and Methanolic Stem Bark Extracts of Piliostigma thonningii (Schum.).","authors":"Gervason Moriasi, Anthony Ireri, Mathew Piero Ngugi","doi":"10.1177/2515690X20937988","DOIUrl":"10.1177/2515690X20937988","url":null,"abstract":"Oxidative stress has been recognized as a key driver of many ailments affecting humankind. Free radicals attack biologically important biomolecules, impairing their functioning, thereby initiating and exacerbating diseases. As a comeback, antioxidant therapies have been proposed as novel approaches to ameliorating oxidative stress-associated diseases including chronic ones. Antioxidants are thought to employ multifaceted and multitargeted mechanisms that either restore oxidative homeostasis or prevent free radical buildup in the body, which overwhelm the endogenous defenses. Plants have been used for many ages across time to manage human diseases, and have a host of antioxidant phytocompounds. Piliostigma thonningii is traditionally used for the management of inflammation, malaria fever, rheumatism, and insanity, among other diseases caused by a disturbed redox state in the body. In this study, in vitro antioxidant activities of the methanolic and aqueous stem bark extracts of P. thonningii were evaluated using the in vitro antilipid peroxidation, the 1,1-diphenyl-2-picryhydrazyl (DPPH) free radical scavenging, and the ferric reducing antioxidant power assay methods. The obtained results revealed remarkable antioxidant activities of the studied plant extracts as evidenced by the low IC50 and EC50 values. These antioxidant activities could be due to the presence of antioxidant phytochemicals like flavonoids, carotenoids, tannins, and phenols, among others. Therefore, the therapeutic potency of this plant could be due to its antioxidant properties. This study recommends in vivo antioxidant efficacy testing of the studied plant extracts, as well as isolation and characterization of bioactive antioxidant compounds that are potent against oxidative stress.","PeriodicalId":15714,"journal":{"name":"Journal of Evidence-based Integrative Medicine","volume":"25 ","pages":"2515690X20937988"},"PeriodicalIF":3.3,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/9a/ae/10.1177_2515690X20937988.PMC7364801.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38159602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0