Journal of Evidence-based Integrative Medicine最新文献

{"title":"Antioxidant, Anti-Inflammatory, Acute Oral Toxicity, and Qualitative Phytochemistry of The Aqueous Root Extract of <i>Launaea cornuta</i> (Hochst. Ex Oliv. & Hiern.).","authors":"Evans Kapanat Akimat,&nbsp;George Isanda Omwenga,&nbsp;Gervason Apiri Moriasi,&nbsp;Mathew Piero Ngugi","doi":"10.1177/2515690X211064585","DOIUrl":"https://doi.org/10.1177/2515690X211064585","url":null,"abstract":"<p><p>The root and leaf extracts of <i>Launaea cornuta</i> have been locally used in traditional medicine for decades to manage inflammatory conditions and other oxidative-stress-related syndromes; however, their pharmacologic efficacy has not been scientifically investigated and validated. Accordingly, we investigated the <i>in vitro</i> antioxidant activity, anti-inflammatory (<i>in vitro, ex vivo,</i> and <i>in vivo</i>) efficacy, acute oral toxicity, and qualitative phytochemical composition of the aqueous root extract of <i>L. cornuta</i>. The ferric-reducing antioxidant power (FRAP) and the 2,2-diphenyl-2-pycrylhydrazyl (DPPH) radical scavenging test methods were used to determine the studied plant extract's antioxidant activity. Besides, the anti-inflammatory efficacy of the studied plant extract was investigated using <i>in vitro</i> (anti-proteinase and protein denaturation), <i>ex vivo</i> (membrane stabilization), and <i>in vivo</i> (carrageenan-induced paw oedema in Swiss albino mice) methods. The studied plant extract demonstrated significant <i>in vitro</i> antioxidant effects, which were evidenced by higher DPPH radical scavenging and FRAP activities, in a concentration-dependent manner (<i>p</i> < 0.05). Generally, the studied plant extract exhibited significant <i>in vitro, ex vivo,</i> and <i>in vivo</i> anti-inflammatory efficacy, respectively, and in a concentration/dose-dependent manner compared with respective controls (<i>p</i> < 0.05). Moreover, the studied plant extract did not cause any observable signs of acute oral toxicity, even at the cut-off dose of 2000 mg/Kg BW (LD₅₀ > 2000 mg/Kg BW), and was thus considered safe. Additionally, qualitative phytochemistry revealed the presence of various antioxidant- and anti-inflammatory-associated phytochemicals, which were deemed responsible for the reported pharmacologic efficacy. Further studies to characterise bioactive molecules and their mode(s) of pharmacologic efficacy are encouraged.</p>","PeriodicalId":15714,"journal":{"name":"Journal of Evidence-based Integrative Medicine","volume":"26 ","pages":"2515690X211064585"},"PeriodicalIF":3.5,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/86/45/10.1177_2515690X211064585.PMC8842406.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39958649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Complementary and Alternative Therapies for Weight Loss: A Narrative Review.","authors":"Pei Lin Lua,&nbsp;Nurul Afiedia Roslim,&nbsp;Aryati Ahmad,&nbsp;Mardiana Mansor,&nbsp;Myat Moe Thwe Aung,&nbsp;Farrahdilla Hamzah","doi":"10.1177/2515690X211043738","DOIUrl":"https://doi.org/10.1177/2515690X211043738","url":null,"abstract":"<p><p>Despite various strategies, overweight and obesity problems are still increasingly prevalent worldwide with serious health outcomes. Consequently, the continuous demand for more effective, safe and acceptable therapies for reducing body weight is also escalating-including complementary and alternative therapies (CATs). The aim of this review is to provide a summary of the most commonly- and recently-used CATs, with evaluation of their safety and efficacy for weight loss. Electronic scientific databases such as Scopus, PubMed and EBSCO Host were explored for articles that reported CATs for overweight and obesity treatment from 2015 to December 2019. Only systematic reviews, meta-analysis and randomized controlled trials (RCTs) published in English were included. Studies whereby CATs were not utilized for reducing body weight were excluded. Eight systematic reviews and meta-analyses and 11 additional RCTs with 765 participants (50.2% overweight and 49.8% obese) related to hypnotherapy, acupuncture and dietary supplements met the inclusion criteria. Their results suggested that spirulina, chitosan, probiotic, EPA + DHA, vitamin D, fiber, and herbal extract supplementation may all provide small reductions in body weight (ranging from 1-10 kg). Interestingly, hypnotherapy and acupuncture reported significantly greater reduction in body weight compared with placebo (p < 0.001 and p < 0.0001, respectively). Nonetheless, the evidence is still relatively limited and not encouraging to provide a definitive conclusion due to the methodological shortcomings and the presence of adverse events in chitosan and fiber supplementation. Hence, studies of this nature need to be further replicated and improved to corroborate the efficacy and safety of the CATs to combat weight issues.</p>","PeriodicalId":15714,"journal":{"name":"Journal of Evidence-based Integrative Medicine","volume":"26 ","pages":"2515690X211043738"},"PeriodicalIF":3.5,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/b9/05/10.1177_2515690X211043738.PMC8436299.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39395737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the Biochemical Basis of the Meridian Tropism Theory for the Qi-Invigorating Traditional Chinese Medicine Herb <i>Panax ginseng</i>.","authors":"Mengmei Li,&nbsp;Yu Chen,&nbsp;Zhongzhen Cai,&nbsp;Jie Teng,&nbsp;Qian Feng,&nbsp;Yuming Chen,&nbsp;Lin Wang,&nbsp;Caixia Li,&nbsp;Bruce Qing Tang,&nbsp;Xuemei Bai","doi":"10.1177/2515690X20983249","DOIUrl":"https://doi.org/10.1177/2515690X20983249","url":null,"abstract":"<p><p>We examined the effect of the Qi-invigorating Traditional Chinese Medicines (TCM) herb <i>Panax ginseng</i> (<i>P.G.</i>) on mitochondrial functions and cellular antioxidant capacity in different organs of mice. We found that the <i>P.G.</i> extracts had a significant effect on tissues of mice, with the generation of total adenylate pool (TAP) enhanced in all visceral tissues, but not for the brain. The mitochondrial membrane potential (MMP) and antioxidant capacity reflected by superoxide dismutase (SOD) and glutathione (GSH) increased only for the meridian tissues that <i>P.G.</i> belongs to including Heart, Spleen and Lung. Reactive oxygen species (ROS), as a combined result of the increased energy metabolism and antioxidant capacity, varied in different organs. We concluded that: 1) the Qi-invigorating TCM herb <i>P.G.</i> had a significant effect on mice by enhancing TAP production in all of the visceral tissues examined, except for the brain; 2) for the meridional tissues of <i>P.G.</i> (Heart, Spleen and Lung), the <i>P.G.</i> extracts not only promoted the TAP production, but also boosted the antioxidant capacity demonstrated by the simultaneous increase in TAP, and SOD and GSH.</p>","PeriodicalId":15714,"journal":{"name":"Journal of Evidence-based Integrative Medicine","volume":"26 ","pages":"2515690X20983249"},"PeriodicalIF":3.5,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/2515690X20983249","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25406717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Licorice: A Potential Herb in Overcoming SARS-CoV-2 Infections.","authors":"Swee Li Ng, Kooi-Yeong Khaw, Yong Sze Ong, Hui Poh Goh, Nurolaini Kifli, Siew Phooi Teh, Long Chiau Ming, Vijay Kotra, Bey Hing Goh","doi":"10.1177/2515690X21996662","DOIUrl":"10.1177/2515690X21996662","url":null,"abstract":"<p><p>The management of the global pandemic outbreak due to the coronavirus disease (COVID-19) has been challenging with no exact dedicated treatment nor established vaccines at the beginning of the pandemic. Nonetheless, the situation seems to be better controlled with the recent COVID-19 vaccines roll-out globally as active immunisation to prevent COVID-19. The extensive usage and trials done in recent outbreak in China has shown the effectiveness of traditional Chinese Medicines (TCM) in improving the wellbeing of COVID-19 patients. Therefore, COVID-19 Prevention and Treatment guidelines has listed a number of recommended concoctions meant for COVID-19 patients. Licorice, more commonly known as Gancao in Chinese Pinyin, is known as one of the most frequently used ingredients in TCM prescriptions for treatment of epidemic diseases. Interestingly, it is deemed as food ingredient as well, where it is normally used in Western cuisines' desserts and sweets. The surprising fact that licorice appeared in the top 10 main ingredients used in TCM prescriptions in COVID-19 has drawn great attention from researchers in revealing its biological potential in overcoming this disease. To date, there are no comprehensive review on licorice and its benefits when used in COVID-19. Thus, in this current review, the possible benefits, mechanism of actions, safety and limitations of licorice were explored in hope to provide a quick reference guide for its preclinical and clinical experimental set-up in this very critical moment of pandemic.</p>","PeriodicalId":15714,"journal":{"name":"Journal of Evidence-based Integrative Medicine","volume":"26 ","pages":"2515690X21996662"},"PeriodicalIF":3.5,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/19/3e/10.1177_2515690X21996662.PMC8020229.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25535521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Natural Supplements for COVID19-Background, Rationale, and Clinical Trials.","authors":"Melody Hermel,&nbsp;Megan Sweeney,&nbsp;Yu-Ming Ni,&nbsp;Robert Bonakdar,&nbsp;Douglas Triffon,&nbsp;Christopher Suhar,&nbsp;Sandeep Mehta,&nbsp;Sarah Dalhoumi,&nbsp;James Gray","doi":"10.1177/2515690X211036875","DOIUrl":"https://doi.org/10.1177/2515690X211036875","url":null,"abstract":"<p><p>Worldwide, the turmoil of the SARS-CoV-2 (COVID-19) pandemic has generated a burst of research efforts in search of effective prevention and treatment modalities. Current recommendations on natural supplements arise from mostly anecdotal evidence in other viral infections and expert opinion, and many clinical trials are ongoing. Here the authors review the evidence and rationale for the use of natural supplements for prevention and treatment of COVID-19, including those with potential benefit and those with potential harms. Specifically, the authors review probiotics, dietary patterns, micronutrients, antioxidants, polyphenols, melatonin, and cannabinoids. Authors critically evaluated and summarized the biomedical literature published in peer-reviewed journals, preprint servers, and current guidelines recommended by expert scientific governing bodies. Ongoing and future trials registered on clinicaltrials.gov were also recorded, appraised, and considered in conjunction with the literature findings. In light of the controversial issues surrounding the manufacturing and marketing of natural supplements and limited scientific evidence available, the authors assessed the available data and present this review to equip clinicians with the necessary information regarding the evidence for and potential harms of usage to promote open discussions with patients who are considering dietary supplements to prevent and treat COVID-19.</p>","PeriodicalId":15714,"journal":{"name":"Journal of Evidence-based Integrative Medicine","volume":"26 ","pages":"2515690X211036875"},"PeriodicalIF":3.5,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/8b/52/10.1177_2515690X211036875.PMC8369961.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39315459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antimalarial Activity of Seed Extracts of <i>Schinus molle</i> Against <i>Plasmodium berghei</i> in Mice.","authors":"Abebe Basazn Mekuria,&nbsp;Mestayet Geta,&nbsp;Eshetie Melese Birru,&nbsp;Desalegn Asmelashe Gelayee","doi":"10.1177/2515690X20984287","DOIUrl":"https://doi.org/10.1177/2515690X20984287","url":null,"abstract":"<p><strong>Background: </strong>Malaria is a major public health problem in developing countries. In Ethiopian, the seeds of <i>Schinus molle</i> are used for the management of malaria. Therefore, the current study aimed to evaluate <i>in vivo</i> antimalarial activity of hydro-alcoholic crude extract and solvent fractions of <i>Schinus molle</i> seeds in <i>Plasmodium berghei</i> infected mice.</p><p><strong>Methods: </strong>An 80 percent of methanolic crude extract and solvent fractions of <i>Schinus molle</i> seeds were tested for antimalarial activity at 100, 200 and 400 mg/kg doses. The parasitemia level, packed cell volume, body weight, survival of date and rectal temperature were used to evaluate the anti-malarial activity of the extracts. One-way ANOVA followed by post hoc Tukey's HSD multiple comparison test was employed and the result was expressed in mean ± SEM (standard error of the mean).</p><p><strong>Results: </strong>The curative activity of the highest dose of crude extract and aqueous fraction of <i>Schinus molle</i> seeds was 69.86% and 73.82% (<i>p</i> < 0.001), respectively. In the prophylactic test, aqueous fraction had 72.39% (<i>p</i> < 0.001) suppression antimalarial activity. Among solvent fractions, only chloroform fraction was significantly attenuated packed cell volume reduction. The mice treated with crude extract and aqueous fraction had longer survival date than vehicle-treated mice (<i>p</i> < 0.001).</p><p><strong>Conclusion: </strong>The experiment finding showed that the crude extract and solvent fractions of <i>Schinus molle</i> seeds had significant curative and prophylaxis anti-plasmodial activity. This result revealed that the <i>Schinus molle</i> seeds extract has promising antimalarial activity against <i>Plasmodium berghei</i>. However, further confirmatory studies, isolation and characterization of the active constituents are recommended.</p>","PeriodicalId":15714,"journal":{"name":"Journal of Evidence-based Integrative Medicine","volume":"26 ","pages":"2515690X20984287"},"PeriodicalIF":3.5,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/2515690X20984287","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25378145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Toxicity and Antimicrobial Activities of <i>Amaranthus caudatus</i> L. (Amaranthaceae) Harvested From Formulated Soils at Different Growth Stages.","authors":"Muhali Olaide Jimoh, Anthony Jide Afolayan, Francis Bayo Lewu","doi":"10.1177/2515690X20971578","DOIUrl":"10.1177/2515690X20971578","url":null,"abstract":"<p><p>This study examined the toxicity and antimicrobial effects of ethanol and aqueous extracts from <i>Amaranthus caudatus</i> grown on soils formulated from parent particles of silt, sand and clay in a glasshouse. Four different soils namely; sandy clay loam, loam, clayey loam and silty clay loam from were formulated were used for cultivation with the unfractionated soil which was the control. Crude extracts obtained from the plant shoots harvested at different growth stages were tested on some certain gram-negative and gram-positive bacteria and some fungi via agar dilution assay. The toxicity of the water and ethanol extracts was also examined via <i>Artemia salina</i> assay and the level of lethality was measured against Clarkson's lethality scale. All aqueous samples, as well as ethanol extracts of flowering and pre-flowering harvests of control soil tested, were non-toxic (LC₅₀ > 1 mg/mL). At post flowering, the ethanolic extracts were highly toxic mostly in clayey loam, control, sandy-clayey loam soils (LC₅₀ < 0.5 mg/mL). Also, antifungal effects of the plant revealed that extracts inhibited the growth of <i>Candida albicans</i> significantly with mild effect on <i>Candida glabrata</i>, <i>Penicillium chrysogenum</i> and <i>Penicillium aurantiogriseum</i> suggesting that the plant is a promising pharmacological candidate in the treatment of candidiasis. For an optimal yield of non-toxic supplement for household consumption which may also serve as pharmacological precursors, clayey loam soil is recommended for cultivation and harvesting may occur at pre-flowering or flowering stage using ethanol and water as solvents of extraction.</p>","PeriodicalId":15714,"journal":{"name":"Journal of Evidence-based Integrative Medicine","volume":"25 ","pages":"2515690X20971578"},"PeriodicalIF":3.5,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/2515690X20971578","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38643848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anti-Proliferative and Pro-Apoptotic Effects of <i>Calligonum comosum</i> (L'Her.) Methanolic Extract in Human Triple-Negative MDA-MB-231 Breast Cancer Cells.","authors":"Zeyad Alehaideb, Saleh AlGhamdi, Wesam Bin Yahya, Hamad Al-Eidi, Mashael Alharbi, Monira Alaujan, Abeer Albaz, Muruj Tukruni, Atef Nehdi, Maha-Hamadien Abdulla, Sabine Matou-Nasri","doi":"10.1177/2515690X20978391","DOIUrl":"10.1177/2515690X20978391","url":null,"abstract":"<p><p>Triple-negative breast cancer (TNBC), the most aggressive subtype, does not respond to targeted therapy due to the lack of hormone receptors. There is an urgent need for alternative therapies, including natural product-based anti-cancer drugs, at lower cost. We investigated the impact of a <i>Calligonum comosum</i> L'Hér. methanolic extract (CcME) on the TNBC MDA-MB-231 cell line proliferation and related cell death mechanisms performing cell viability and cytotoxicity assays, flow cytometry to detect apoptosis and cell cycle analysis. The apoptosis-related protein array and cellular reactive oxygen species (ROS) assay were also carried out. We showed that the CcME inhibited the TNBC cell viability, in a dose-dependent manner, with low cytotoxic effects. The CcME-treated TNBC cells underwent apoptosis, associated with a concomitant increase of apoptosis-related protein expression, including cytochrome c, cleaved caspase-3, cyclin-dependent kinase inhibitor p21, and the anti-oxidant enzyme catalase, compared with the untreated cells. The CcME also enhanced the mitochondrial transition pore opening activity and induced G₀/G₁ cell growth arrest, which confirmed the cytochrome c release and the increase of the p21 expression detected in the CcME-treated TNBC cells. The CcME-treated TNBC cells resulted in intracellular ROS production, which, when blocked with a ROS scavenger, did not reduce the CcME-induced apoptosis. In conclusion, CcME exerts anti-proliferative effects against TNBC cells through the induction of apoptosis and cell growth arrest. <i>In vivo</i> studies are justified to verify the CcME anti-proliferative activities and to investigate any potential anti-metastatic activities of CcME against TNBC development and progression.</p>","PeriodicalId":15714,"journal":{"name":"Journal of Evidence-based Integrative Medicine","volume":"25 ","pages":"2515690X20978391"},"PeriodicalIF":3.5,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/2515690X20978391","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38696733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Toxicity and Activity of Ethanolic Leaf Extract of <i>Paullinia pinnata</i> Linn (Sapindaceae) in <i>Shigella flexneri</i>-Induced Diarrhea in Wistar Rats.","authors":"Maximilienne Ascension Nyegue,&nbsp;Alian Désiré Afagnigni,&nbsp;Youchahou Njankouo Ndam,&nbsp;Steve Valdi Djova,&nbsp;Marie Christine Fonkoua,&nbsp;François-Xavier Etoa","doi":"10.1177/2515690X19900883","DOIUrl":"https://doi.org/10.1177/2515690X19900883","url":null,"abstract":"<p><p>Herbal products from <i>Paullinia pinnata</i> Linn are widely used in African folk medicine to treat several infectious diseases. Although the extracts from this plant has been shown to possess antimicrobial potential, their activity in infectious diarrhea is less reported. Diarrhea was induced by oral administration of 1.2 × 10⁹ CFU/mL of <i>Shigella flexneri</i> to the rats. The infected rats were treated for 5 days with the doses of 111.42, 222.84, and 445.68 mg/kg of <i>P pinnata</i>. The level of biochemical parameters was assessed and histology of organs examined by 14 days subacute toxicity. <i>S flexneri</i> stool load was considerably reduced after 4 days of treatment with the dose of 445.68 mg/kg, 5 days at the dose of 222.84 mg/kg for the extract, and 2 days with ciprofloxacin. The dose of 111.42 mg/kg appeared efficient after 5 days of treatment. The creatinine level increased at the dose of 445.68 mg/kg in both male and female rats and decrease at the dose of 222.84 mg/mL in female rats while an increase was noted in the male rats. Liver and kidney histology were modified at the dose of 445.68 mg/kg while no change was observed at the doses of 111.42 and 222.84 mg/kg. <i>P pinnata</i> leaf extract is efficient against infectious diarrhea at 111.42 mg/kg without side effect.</p>","PeriodicalId":15714,"journal":{"name":"Journal of Evidence-based Integrative Medicine","volume":"25 ","pages":"2515690X19900883"},"PeriodicalIF":3.5,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/2515690X19900883","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37569148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Feasibility and Efficacy of a Brief Integrative Treatment for Adults With Depression and/or Anxiety: A Randomized Controlled Trial.","authors":"Adrian L Lopresti,&nbsp;Stephen J Smith,&nbsp;Alexandra P Metse,&nbsp;Tiffany Foster,&nbsp;Peter D Drummond","doi":"10.1177/2515690X20937997","DOIUrl":"https://doi.org/10.1177/2515690X20937997","url":null,"abstract":"<p><p>The aim of this study was to investigate the efficacy and suitability of a brief integrative intervention, Personalized Integrative Therapy (PI Therapy), for the treatment of adult depression and/or anxiety. In this 6-week, 3-arm, parallel-group, randomized trial, PI Therapy delivered alone or with nutritional supplements (PI Therapy + Supps) was compared to cognitive behavior therapy (CBT) in 48 adults with depression and/or anxiety. All treatments were delivered as a 1-day workshop plus 6 weeks of reminder phone text messages to reinforce topics and skills covered in the workshop. Affective symptoms decreased significantly and to the same extent in all 3 conditions. At the end of treatment, 33% to 58% of participants reported levels of depressive symptoms in the normal range, and 50% to 58% reported nonclinical levels of anxiety. Compared to CBT and PI Therapy, PI Therapy + Supps was associated with significantly greater improvements in sleep quality. These findings suggest that a brief integrative intervention with or without supplements was comparable to CBT in reducing affective symptoms in adults with depression and/or anxiety. However, sleep quality improved only in the PI Therapy + Supps condition. These findings will require replication with a larger cohort.</p>","PeriodicalId":15714,"journal":{"name":"Journal of Evidence-based Integrative Medicine","volume":"25 ","pages":"2515690X20937997"},"PeriodicalIF":3.5,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/2515690X20937997","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38130229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}