{"title":"含柚木叶提取物的生发配方的有效性和安全性：一项针对雄激素性脱发男性患者的随机、双盲、安慰剂对照研究。","authors":"Nutchaninad Tanuphol, Neti Waranuch, Vanuchawan Wisuitiprot, Wudtichai Wisuitiprot, Kamonlak Insumrong, Prapapan Temkitthawon, Nungruthai Suphrom, Katechan Jampachaisri, Corine Girard, Kornkanok Ingkaninan","doi":"10.1177/2515690X241291141","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Androgenic alopecia (AGA) is commonly known as male patterned baldness. A high level of dihydrotestosterone (DHT) plays a significant role in AGA development. Inhibition of the enzyme steroid 5-alpha reductase (S5AR), responsible for converting testosterone into DHT, has been shown to delay the progression of AGA. Teak (<i>Tectona grandis</i> L.f) leaf extract exhibited a potent S5AR inhibitory activity. To prove the effectiveness and safety of teak leaf extract as a hair growth promotor, a double-blind, randomized placebo-controlled trial was conducted.</p><p><strong>Methods: </strong>Eighty-one AGA subjects were randomly assigned to receive either a hair tonic containing 1% teak leaf extract (HT-teak), 5%minoxidil (positive control), or a placebo administered twice daily, for 24 weeks. Efficacy was assessed through target area hair count (TAHC), anagen-to-telogen ratio (A/T), hair shedding every 4 weeks, and patients' subjective assessments of hair regrowth were assessed at the end of the experiment. Data was analyzed using repeated measure ANOVA.</p><p><strong>Results: </strong>Both the HT-teak and minoxidil groups exhibited a significant increase in TAHC and A/T, along with a decrease in hair shedding compared to baseline values. Conversely, the placebo group showed no observable signs of hair regrowth. Furthermore, the HT-teak group reported the highest satisfaction scores, and there were no indications of skin irritation or systemic effects on sexual dysfunction and palpitation after 24 weeks of HT-teak application.</p><p><strong>Conclusion: </strong>Teak leaf extract, as incorporated in HT-teak, demonstrates potential as an alternative mild hair growth promoter for individuals with AGA, offering both efficacy and safety.</p><p><strong>Trial registration: </strong>This study was retrospectively registered on International Standard Randomised Controlled Trial Number (ISRCTN.com); ISRCTN24541842 (registered on January 8, 2024).</p>","PeriodicalId":15714,"journal":{"name":"Journal of Evidence-based Integrative Medicine","volume":null,"pages":null},"PeriodicalIF":3.3000,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Effectiveness and Safety of Hair Growth Formulation Containing <i>Tectona grandis</i> L.f (Teak) Leaf Extract: A Randomized, Double-Blind, Placebo-Controlled Study on Males with Androgenic Alopecia.\",\"authors\":\"Nutchaninad Tanuphol, Neti Waranuch, Vanuchawan Wisuitiprot, Wudtichai Wisuitiprot, Kamonlak Insumrong, Prapapan Temkitthawon, Nungruthai Suphrom, Katechan Jampachaisri, Corine Girard, Kornkanok Ingkaninan\",\"doi\":\"10.1177/2515690X241291141\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Androgenic alopecia (AGA) is commonly known as male patterned baldness. 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Data was analyzed using repeated measure ANOVA.</p><p><strong>Results: </strong>Both the HT-teak and minoxidil groups exhibited a significant increase in TAHC and A/T, along with a decrease in hair shedding compared to baseline values. Conversely, the placebo group showed no observable signs of hair regrowth. 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引用次数: 0
摘要
背景：雄激素性脱发（AGA）俗称男性型秃发。高水平的双氢睾酮（DHT）在 AGA 的发病中起着重要作用。抑制负责将睾酮转化为双氢睾酮的类固醇 5-α还原酶（S5AR）已被证明可以延缓 AGA 的发展。柚木（Tectona grandis L.f）叶提取物具有强效的 S5AR 抑制活性。为了证明柚木叶提取物作为生发促进剂的有效性和安全性，我们进行了一项双盲、随机安慰剂对照试验：81名AGA受试者被随机分配到含有1%柚叶提取物（HT-teak）、5%米诺地尔（阳性对照）或安慰剂的生发剂中，每天服用两次，连续服用24周。疗效通过目标区毛发计数（TAHC）、生长期与新生期毛发比率（A/T）、每 4 周一次的毛发脱落情况进行评估，并在实验结束时评估患者对毛发再生的主观评价。数据采用重复测量方差分析：与基线值相比，HT-teak 组和米诺地尔组的 TAHC 和 A/T 均有显著增加，头发脱落也有所减少。相反，安慰剂组则没有明显的头发再生迹象。此外，HT-柚木组的满意度得分最高，在使用 HT- 柚木 24 周后，没有迹象表明皮肤受到刺激，或对性功能障碍和心悸产生系统性影响：结论：HT-teak 中的柚叶提取物具有促进 AGA 患者毛发生长的潜力，是一种替代性的温和生发剂，既有效又安全：本研究在国际标准随机对照试验编号（ISRCTN.com）上进行了回顾性注册；ISRCTN24541842（注册日期：2024年1月8日）。
Effectiveness and Safety of Hair Growth Formulation Containing Tectona grandis L.f (Teak) Leaf Extract: A Randomized, Double-Blind, Placebo-Controlled Study on Males with Androgenic Alopecia.
Background: Androgenic alopecia (AGA) is commonly known as male patterned baldness. A high level of dihydrotestosterone (DHT) plays a significant role in AGA development. Inhibition of the enzyme steroid 5-alpha reductase (S5AR), responsible for converting testosterone into DHT, has been shown to delay the progression of AGA. Teak (Tectona grandis L.f) leaf extract exhibited a potent S5AR inhibitory activity. To prove the effectiveness and safety of teak leaf extract as a hair growth promotor, a double-blind, randomized placebo-controlled trial was conducted.
Methods: Eighty-one AGA subjects were randomly assigned to receive either a hair tonic containing 1% teak leaf extract (HT-teak), 5%minoxidil (positive control), or a placebo administered twice daily, for 24 weeks. Efficacy was assessed through target area hair count (TAHC), anagen-to-telogen ratio (A/T), hair shedding every 4 weeks, and patients' subjective assessments of hair regrowth were assessed at the end of the experiment. Data was analyzed using repeated measure ANOVA.
Results: Both the HT-teak and minoxidil groups exhibited a significant increase in TAHC and A/T, along with a decrease in hair shedding compared to baseline values. Conversely, the placebo group showed no observable signs of hair regrowth. Furthermore, the HT-teak group reported the highest satisfaction scores, and there were no indications of skin irritation or systemic effects on sexual dysfunction and palpitation after 24 weeks of HT-teak application.
Conclusion: Teak leaf extract, as incorporated in HT-teak, demonstrates potential as an alternative mild hair growth promoter for individuals with AGA, offering both efficacy and safety.
Trial registration: This study was retrospectively registered on International Standard Randomised Controlled Trial Number (ISRCTN.com); ISRCTN24541842 (registered on January 8, 2024).
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