Japanese Journal of Smooth Muscle Research最新文献

{"title":"PROSTAGLANDIN F2α の術後消化管運動におよぼす影響について","authors":"茂二 福西, 信一 天野, 英郎 西城, 好市 松本, 圭二 入山, 敏行 藤野","doi":"10.1540/JSMR1965.13.141","DOIUrl":"https://doi.org/10.1540/JSMR1965.13.141","url":null,"abstract":"The effect of prostaglandin F2α was studied clinically and electromyographically on the motility of the gastric antrum, duodenum, jejunum, ileum and transverse colon in 20 patients by giving 2 hours intravenous drip infusion at 0.3-0.5 μg/kg/min for 2 hours after major abdominal surgery. Following results were obtained.1. The motility of stomach and colon was least active than any other site of alimentary tract during 48 hours after surgery. This seems to be one of the most important causes of so called postoperative ileus.2. Recovery from reflex inhibition of motility of the alimentary tract after surgery was seen in duodenum at first, and then in jejunum and ileum in order.3. It was proved that intravenous drip infusion of PGF2α, at 0.3-0.5 μg/kg/min for 2 hours had produced the increase of electrical activity in any site of gastrointestinal tract and subsequently brought about the increasing of propulsive movement. The effect of PGF2α is proportional to its concentration.4. It was concluded that PGF2α could be administered most effectively by intravvenous drip infusion at 0.5 μg/kg/min 3 times daily for 3 days after surgery for the satisfactory recovery from the postoperative ileus, and no appreciable side effect was observed.","PeriodicalId":156233,"journal":{"name":"Japanese Journal of Smooth Muscle Research","volume":"75 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1977-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133079377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A STUDY OF THE HUMAN ELECTROGASTROGRAM USING CUTANEOUS ELECTRODES","authors":"S. Kohatsu","doi":"10.1540/JSMR1965.4.148","DOIUrl":"https://doi.org/10.1540/JSMR1965.4.148","url":null,"abstract":"Since Alvarez first recorded the el ectrical waves from the human stomach in 1922, many investigators, both basic scientists and clinicians have contributed to our understanding of the eletrophysiology of the stomach. These studies have ranged from recordings of electrical activity from within the cell to recordings from the intact stomachs of man and animals. Various investigators have attempted to apply this knowledge to the study of human gastric physiology and abnormalities of the stomach, such as gastric ulcer, gastric carcinoma, and dumping syndrome. Many of the early investigators in the United States used cutaneous or swallowed electrodes, and their analysis of the electrogastrograms primarily stressed the variations of wave form, the DC potential, and the amplitudes of the waves with minimal analysis of rate variations. By the nature of the recordings obtainable with their electrodes and their method of recording, in light of our present understanding of electrophysiology of smooth muscle and electrodes, some of their data are difficult to interpret. Several groups in Japan have improved upon the swallowed electrode and have been able to obtain good electrical recordings from the human stomach. The analysis of their electrogastrograms have emphasized variations of wave form, amplitude, conduction, and also the variations of rate. The findings in normals and the variations from the normal in certain gastric abnormalities suggest the clinical possibilities of the electrogastrogram. We too became interested in studying the electrophysiology of the human stomach several years ago. We started our studies with swallowed electrodes, but found that many of our subjects would not tolerate a tube for any length of time and often became nauseated. In addition we were interested in studying the response of the stomach to a meal, and felt that it would be better not to have a tube within the stomach. We appreciated the disadvantages of the cutaneous electrodes, but we were primarily interested in obtaining electrogastrograms adequate for analysis of rate variations. The following study was undertaken to: 1) evaluate the efficacy of a cutaneous electrode; 2) establish the fasting rate of normal subjects using this electrode; and 3) determine the pattern of electrical rate change following ingestion of a meal.","PeriodicalId":156233,"journal":{"name":"Japanese Journal of Smooth Muscle Research","volume":"76 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1968-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116410881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"胃腸管に対するPyrodifenium bromide (Padrin) の実験的ならびに臨床的効果","authors":"常男 白鳥, 長 塚本, 禎量 斎藤, 謙 長岡","doi":"10.1540/JSMR1965.3.140","DOIUrl":"https://doi.org/10.1540/JSMR1965.3.140","url":null,"abstract":"","PeriodicalId":156233,"journal":{"name":"Japanese Journal of Smooth Muscle Research","volume":"102 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1967-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124977066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"1, 1-diethy1-2-methy1-3-diphenylmethylene pyrrolidinium bromide (Pyrodifenium bromide) の胃腸運動に及ぼす作用","authors":"武彦 福原, 沃 中山, 良司 難波, 博之 福田, 俊昭 禰屋","doi":"10.1540/JSMR1965.3.94","DOIUrl":"https://doi.org/10.1540/JSMR1965.3.94","url":null,"abstract":"","PeriodicalId":156233,"journal":{"name":"Japanese Journal of Smooth Muscle Research","volume":"66 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1967-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124854795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"N-(diethylaminoethyl)-2-methoxy-4-amino-5-chlorobenzamide dihydrochloride (Métoclopramide) の腸管運動におよぼす効果","authors":"武彦 福原, 沃 中山, 博之 福田, 俊昭 禰屋","doi":"10.1540/JSMR1965.3.19","DOIUrl":"https://doi.org/10.1540/JSMR1965.3.19","url":null,"abstract":"ヒトの治療量10-30mg, 体重50kgとして0.2-0.6mg/kgに相当する量のMetoclopramideをイヌに静注するとき, 胃腸の壁内神経性要素および脊髄中枢の麻痺が招来されるかどうかを研究した.壁内神経性要素の健否の指標としては粘膜内反射効果および迷走神経刺激効果を, 脊髄反射中枢の健否の指標としては小腸―小腸反射あるいは小腸―胃反射を用いた.これら実験の結果によれば, Metoclopramideのヒトの治療量に相当する量はイヌの壁内神経性要素ならびに脊髄反射中枢に対して認むべき麻痺作用をおよぼさないと結論することができる.","PeriodicalId":156233,"journal":{"name":"Japanese Journal of Smooth Muscle Research","volume":"27 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1967-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122437007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"N-(diethylaminoethyl)-2-methoxy-4-amino-5-chlorobenzamide dihydrochlorideの胃および小腸運動におよぼす効果","authors":"武彦 福原, 沃 中山, 博之 福田, 宏 椎名, 俊昭 禰屋","doi":"10.1540/JSMR1965.2.15","DOIUrl":"https://doi.org/10.1540/JSMR1965.2.15","url":null,"abstract":"1. The effects of N-(diethylaminoethyl)-2-methoxy-4-amino-5-chlorobenz-amide dihydrochloride (metoclopramide) upon the motility of the stomach as well as of the small intestine of dogs were studied.2. In the stomach, when 0.2-10mg/kg of metoclopramide was administered intravenously, there was produced a slight to moderate rise of tone superimposed with the gastric peristalses with increased amplitude. The emptying of the gastric content was accelerated when the rise of tone is of a slight degree, whereas it was retarded when the tone considerably rose.3. In the small intestine, when 0.2-20mg/kg metoclopramide was administered intravenously, the excitatory effect was most frequently produced, occasionally an inhibitory effect or a transitory inhibition followed by an excitation was also observed.4. It is presumed that the drug acts upon the intramural nervous elements and/or the intestinal muscle, since the effects of the drug seen after the severance of extraintestinal autonomic nerves were the same as those observed before the severance of the nerves.","PeriodicalId":156233,"journal":{"name":"Japanese Journal of Smooth Muscle Research","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1966-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114828875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"腸管運動に対するN-(diethylaminoethyl)-2-methoxy-4-amino-5-chlorobenzalnide dihydrochloride (Métoclopramide) の作用機序","authors":"武彦 福原, 沃 中山, 博之 福田, 俊昭 禰屋","doi":"10.1540/JSMR1965.2.22","DOIUrl":"https://doi.org/10.1540/JSMR1965.2.22","url":null,"abstract":"1) 各種動物特にネズミの別出小腸片の運動におよぼすmetoclopramideの影響ならびにこの薬物の作用点を研究した.2) (a)この薬物は一般に小腸運動の亢進をひきおこした.そして(b)神経節遮断剤, nicotineあるいはhexamethonium適用後においても, またatropine適用後においても, これら薬物の適用前に匹敵する亢進効果をひきおこした.(c)他方この薬物適用後間もなく神経節刺激剤DMPPは無効となり, nicotine適用によって現われるべき一過性亢進効果も認められなくなった.(d)またこの薬物の大量適用後においては腸間膜動脈神経刺激は全く無効であった.3) この薬物の大量適用によって小腸の緊張が極度にたかめられた後に, さらにこの薬物を適用すると著明な緊張低下がおこった.4) これを要するにmetoclopramideは,(a)腸壁内神経要素に対して麻痺的に作用し,(b)筋自身に対しては, 一般に運動亢進的に作用するが, 筋が特殊な状態, たとえば, 異常な緊張上昇状態におかれた場合には.逆に抑制的に作用すると結論することができよう.","PeriodicalId":156233,"journal":{"name":"Japanese Journal of Smooth Muscle Research","volume":"14 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1966-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133363396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ON THE RELATION BETWEEN THE CONFIGURATION OF ACTION POTENTIAL AND THE CONTRACTION OF URETER","authors":"Kazuya Inoue","doi":"10.1540/jsmr1965.1.169","DOIUrl":"https://doi.org/10.1540/jsmr1965.1.169","url":null,"abstract":"By recording the electrogram and mechanogram of the ureter simultaneously, the relationship between the configuration of action potential and contraction was studied.The action potential of the guinea pig's ureter consists of two components, the slow potential and the oscillating spike potential. Tetraethylam-monium (TEA) ion diminished the spike component without affecting the slow component. In this case, the slow potentials appeared repetitively and spontaneously, each of them was accompanied by contraction and the evident summation of contraction could be observed. The contraction of TEA-ureter was of tetanic nature.When NaCl in Krebs solution was substituted by choline chloride, the action potential lost its slow component and there occurred the repetitive burst of grouped spike potentials. The single spike potential evoked the single weak contraction. In each burst, the summation of contraction was recorded. The contraction of choline-ureter was also of tetanic nature.The effect of oxytocin upon the ureter was similar to that of Ca ion deficient environment. By the administration of oxytocin in the soaking fluid, the action potential lost its spike component but the slow component remained unaffected. In this case, however, with the decrease in size of the spike potential, the contraction became weaker and finally disappeared. The disappearance of contraction by oxytocin is due to the disturbance or block of the excitation-contraction coupling.From the facts mentioned above, it could be concluded that both slow and spike components in action potential of the guinea pig's ureter held the ability to evoke the contraction, as far as the excitation-contraction coupling was not disturbed.","PeriodicalId":156233,"journal":{"name":"Japanese Journal of Smooth Muscle Research","volume":"41 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114580921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ELECTROPHYSIOLOGICAL STUDIES ON THE PERISTALTIC PROPAGATION IN THE INTESTINAL BLIND POUCH","authors":"T. Tsujimura","doi":"10.1540/jsmr1965.3.54","DOIUrl":"https://doi.org/10.1540/jsmr1965.3.54","url":null,"abstract":"To clarify the basic conduction pattern of the anastomosed intestine with a blind pouch, the author performed the experiments, in which the action potential was recorded from the blind loop developed following a sideto-side anastomosis after resection of rabbit's intestine and the motile function of the loop was observed.The electrodes were placed at four different sites and the whole preparation was immersed in Tyrode solution.1. Dilatation and hypertrophy of the blind loop were progressive, and diarrhea, weight loss, malnutrition and dehydration were aggravated in time.2. Over more than three months after blind loop formation, iso-peristaltic propagation is seen in a caudal direction and anti-peristaltic conduction from blind end to the entrance of the loop, causing collision of both peristaltic waves. The amplitude of spikes recorded from the distal site was apparently increased.3. In view of the fact that a side-to-side anastomosis may cause blind pouch formation, the superiority of an end-to-end anastomosis over a side-toside anastomosi s is suggested.","PeriodicalId":156233,"journal":{"name":"Japanese Journal of Smooth Muscle Research","volume":"12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126221463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EFFECT OF LIDOCAINE ON MOTILITY OF THE STOMACH","authors":"T. Shiratori, K. Sugawara, N. Harata, T. Hatafuku, T. Sekine, E. Kato","doi":"10.1540/JSMR1965.3.129","DOIUrl":"https://doi.org/10.1540/JSMR1965.3.129","url":null,"abstract":"The effect of locally injected lidocaine on the motor function of the canine stomach was studied. 1) When lidocaine was injected into the muscularis mucosae of the stomach encircling the organ, the peristalsis did not propagate across the injected site. In the portion proximal to the injected site, hypermotility was noted electromyographically consisting of prolonged discharge interval, higher amplitude, occurrence of anti-peristalsis and increase in contraction pressure of the pyloric ring. The hypermotility was seen macroscopically, also. 2) The same results were obtained after injection of lidocaine to anterior or posterior half of the circle of the stomach. 3) Following the injection of lidocaine completely encircling the stomach at two levels of about midportion of the corpus (1/2 level of the stomach) and at the borderline between the corpus and antrum (lower 1/3 level), prolongation of the discharge interval was more marked in the latter instance.","PeriodicalId":156233,"journal":{"name":"Japanese Journal of Smooth Muscle Research","volume":"42 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121968638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}