PROSTAGLANDIN F2α の術後消化管運動におよぼす影響について

Abstract

The effect of prostaglandin F2α was studied clinically and electromyographically on the motility of the gastric antrum, duodenum, jejunum, ileum and transverse colon in 20 patients by giving 2 hours intravenous drip infusion at 0.3-0.5 μg/kg/min for 2 hours after major abdominal surgery. Following results were obtained.1. The motility of stomach and colon was least active than any other site of alimentary tract during 48 hours after surgery. This seems to be one of the most important causes of so called postoperative ileus.2. Recovery from reflex inhibition of motility of the alimentary tract after surgery was seen in duodenum at first, and then in jejunum and ileum in order.3. It was proved that intravenous drip infusion of PGF2α, at 0.3-0.5 μg/kg/min for 2 hours had produced the increase of electrical activity in any site of gastrointestinal tract and subsequently brought about the increasing of propulsive movement. The effect of PGF2α is proportional to its concentration.4. It was concluded that PGF2α could be administered most effectively by intravvenous drip infusion at 0.5 μg/kg/min 3 times daily for 3 days after surgery for the satisfactory recovery from the postoperative ileus, and no appreciable side effect was observed.