ELECTROPHYSIOLOGICAL STUDIES ON THE PERISTALTIC PROPAGATION IN THE INTESTINAL BLIND POUCH

Abstract

To clarify the basic conduction pattern of the anastomosed intestine with a blind pouch, the author performed the experiments, in which the action potential was recorded from the blind loop developed following a sideto-side anastomosis after resection of rabbit's intestine and the motile function of the loop was observed.The electrodes were placed at four different sites and the whole preparation was immersed in Tyrode solution.1. Dilatation and hypertrophy of the blind loop were progressive, and diarrhea, weight loss, malnutrition and dehydration were aggravated in time.2. Over more than three months after blind loop formation, iso-peristaltic propagation is seen in a caudal direction and anti-peristaltic conduction from blind end to the entrance of the loop, causing collision of both peristaltic waves. The amplitude of spikes recorded from the distal site was apparently increased.3. In view of the fact that a side-to-side anastomosis may cause blind pouch formation, the superiority of an end-to-end anastomosis over a side-toside anastomosi s is suggested.