{"title":"From Fallen Angels to Bridal Rights: A Historical Journey of Cosmetics in Sacred Traditions and Their Aesthetic Legacy.","authors":"Kun Hwang","doi":"10.1097/SCS.0000000000012025","DOIUrl":"https://doi.org/10.1097/SCS.0000000000012025","url":null,"abstract":"<p><p>Cosmetics occupy a paradoxical role in human history, functioning both as sacred instruments of ritual and as contested symbols of vanity and seduction. This paper traces the shifting meanings of cosmetics across mythic, religious, and cultural contexts, with a focus on their enduring legacy. The narrative begins with the Book of Enoch, where the fallen angel Azazel imparts forbidden knowledge of beautification, framing cosmetics as a transgressive act that blurred the boundary between divine order and human artifice. Ancient Near Eastern and Mediterranean societies, however, incorporated pigments, perfumes, and ointments into religious rites, where adornment symbolized consecration as well as potential corruption. In the Hellenistic period, elite women, particularly in Ptolemaic and Seleucid contexts, wielded cosmetics as expressions of status and cultural agency, despite philosophical critiques that labeled them deceptive. Bridal adornment emerged as a sanctified practice, enshrined in Jewish and early Christian traditions as both a ritual obligation and a symbol of spiritual fidelity. While Church Fathers such as Tertullian condemned cosmetic use, local customs maintained it as an essential expression of purity and joy. These ancient tensions persisted in subsequent religious debates, with rabbinic, Christian, and ascetic authorities negotiating the fine line between sanctification and vanity. Yet many ancient ingredients and ritual practices survive in modern beauty culture, revealing continuity beneath evolving meanings. Ultimately, cosmetics emerge as cultural constants-mutable in interpretation yet enduring in practice-embodying humanity's perennial effort to reconcile bodily fragility with ideals of beauty, power, and transcendence.</p>","PeriodicalId":15462,"journal":{"name":"Journal of Craniofacial Surgery","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2025-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145300952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Topical 5-FU in Odontogenic Keratocyst: Clinical Outcomes and Molecular Insights.","authors":"Jing-Rui Yi, Shu-Hang Deng, Qi-Wen Man","doi":"10.1097/SCS.0000000000012047","DOIUrl":"https://doi.org/10.1097/SCS.0000000000012047","url":null,"abstract":"<p><p>Odontogenic keratocyst (OKC) is a locally aggressive jaw cyst with a high recurrence rate. This study evaluated the efficacy of topical 5-fluorouracil (5-FU) as an adjunct to enucleation in 12 OKC patients. After cyst removal, residual bone cavities were packed with 5% 5-FU-coated iodoform gauze for 72 hours. Over a mean follow-up of 14 months, all patients healed uneventfully, and one recurrence occurred (8.3%; 95% CI: 0.2%-38.5%) at 12 months. Bulk RNA sequencing revealed enrichment of necroptosis and cellular senescence pathways, with upregulation of pro-apoptotic genes (FAS, TNFRSF10A, TNFRSF10D) and downregulation of proliferation-related genes (TOP2A, CDK1, CDK5) after 5-FU treatment in OKC tissues. These findings support topical 5-FU as a safe, cost-effective, adjuvant therapy that potentially reducing recurrence risk. Validation in larger multicenter studies with extended follow-up is warranted.</p>","PeriodicalId":15462,"journal":{"name":"Journal of Craniofacial Surgery","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2025-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145286201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Successful Puncture and Drainage of Primary Brainstem Hemorrhage With Robotic Assistance.","authors":"Di Tian, Long Liu, Xiaoman Chen, Qi Liu","doi":"10.1097/SCS.0000000000012068","DOIUrl":"https://doi.org/10.1097/SCS.0000000000012068","url":null,"abstract":"<p><p>Primary brainstem hemorrhage (PBH) is characterized by sudden onset, rapid progression, and high mortality. The optimal therapeutic strategy for PBH remains controversial. This case report demonstrates the safety and efficacy of robot-assisted stereotactic puncture and drainage for PBH. A 56-year-old female presented with sudden-onset unconsciousness persisting for 48 hours. Noncontrast cranial computed tomography (CT) revealed a pontine hemorrhage. On the basis of hematoma location and clinical status, robot-assisted stereotactic puncture and drainage was performed. Postoperatively, the patient exhibited gradual neurological improvement without new deficits. At the 3-month follow-up, the patient regained consciousness but required substantial assistance for activities of daily living. Current management focuses on intensive rehabilitation with ongoing clinical surveillance. This case suggests that robot-assisted drainage may enhance procedural safety and efficacy in PBH, potentially improving survival and long-term functional outcomes.</p>","PeriodicalId":15462,"journal":{"name":"Journal of Craniofacial Surgery","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2025-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145280201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Retrospective Analysis of the Results of Mini-Monoka Monocanalicular Stent Intubation in Adult Traumatic Canalicular Laceration Patients.","authors":"Zeki Baysal, Ömer Özer, Levent Doğan","doi":"10.1097/SCS.0000000000012067","DOIUrl":"https://doi.org/10.1097/SCS.0000000000012067","url":null,"abstract":"<p><strong>Objective: </strong>The aim of this study is to evaluate the outcomes of Mini-Monoka (FCI Ophthalmics, Marshfield Hills, MA) monocanalicular stent intubation in adult patients with traumatic canalicular lacerations and to investigate the factors influencing anatomical and functional outcomes.</p><p><strong>Methods: </strong>All patients aged 18 years and older who underwent surgery for traumatic canalicular lacerations at the Niğde Ömer Halisdemir University Ophthalmology Department between August 2023 and December 2024 were included in the study.</p><p><strong>Results: </strong>Anatomical success was achieved in all patients included in the study, but functional success was not achieved in 2 patients. Two (3.9%) of the patients who did not achieve functional success had accompanying punctum laceration. The most common accompanying pathology was eyelid margin involvement in 45 (86.5%) patients and orbicularis oculi injury in 23 (44.2%) patients.</p><p><strong>Conclusions: </strong>In conclusion, the Mini-Monoka stent application is a reliable, inexpensive, and effective method for patients with canalicular trauma. While it achieves quite satisfactory anatomical and functional success in simple cases, additional interventions may be required to achieve functional success in complex and severe cases.</p>","PeriodicalId":15462,"journal":{"name":"Journal of Craniofacial Surgery","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2025-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145280175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Judith Monzy, Emily L Isch, Meryem Guler, Emily Yanoshak, Edward J Caterson
{"title":"Nasal Glioma in a Newborn With Suspected Pai Syndrome: Surgical and Diagnostic Insights.","authors":"Judith Monzy, Emily L Isch, Meryem Guler, Emily Yanoshak, Edward J Caterson","doi":"10.1097/SCS.0000000000012061","DOIUrl":"https://doi.org/10.1097/SCS.0000000000012061","url":null,"abstract":"<p><strong>Introduction: </strong>Nasal glial heterotopias, or nasal gliomas, are rare congenital midline lesions composed of ectopic, non-neoplastic glial tissue. They are often mistaken for encephaloceles due to overlapping clinical and embryologic features. Accurate diagnosis is essential to avoid complications associated with surgical intervention.</p><p><strong>Methods: </strong>The authors present the case of a newborn female infant born at 35 weeks and 6 days of gestation with a midline nasal mass, respiratory distress, and multiple dysmorphic features. Prenatal and postnatal imaging revealed a pedunculated nasal lesion without intracranial extension and a corpus callosal lipoma suggestive of Pai syndrome. The mass was surgically excised on day of life 2, and tissue was sent for histopathologic evaluation.</p><p><strong>Results: </strong>Pathology confirmed a benign fibroepithelial polyp with rare nerve fibers and negative GFAP staining, consistent with nasal glioma. Postoperatively, the patient exhibited persistent hypotonia, respiratory, and feeding difficulties. Imaging revealed bilateral vestibulocochlear nerve atresia and a hypoplastic facial nerve. Genetic evaluation for Pai syndrome is ongoing.</p><p><strong>Conclusion: </strong>This case highlights the diagnostic and management challenges of nasal gliomas, particularly when associated with syndromic features. MRI is critical for preoperative assessment to exclude intracranial communication. Early surgical excision and multidisciplinary follow-up are essential for optimal outcomes in affected neonates.</p>","PeriodicalId":15462,"journal":{"name":"Journal of Craniofacial Surgery","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2025-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145280153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Intraoperative Analysis of Unilateral Cleft Lip Nasal Deformity: Assessment of the Lower Lateral Cartilage Following Correction of the Nasal Foundation and Nasal Tip Dissection Via a Modified Tajima Incision.","authors":"Daniela Tanikawa, Álvaro Figueroa, David Chong","doi":"10.1097/SCS.0000000000012026","DOIUrl":"https://doi.org/10.1097/SCS.0000000000012026","url":null,"abstract":"<p><strong>Background: </strong>Achieving consistent correction of unilateral cleft lip nasal deformity (uCLND) remains challenging due to the complex interplay between skeletal, soft tissue, and cartilaginous components. This study evaluates intraoperative lower lateral cartilage (LLC) distortions, their distribution, and their associations with cleft characteristics and presurgical infant orthopedics (PSIO), using the modified Tajima incision for direct visualization.</p><p><strong>Methods: </strong>Fifty patients undergoing unilateral cleft lip repair with foundation-based primary rhinoplasty were analyzed. Intraoperative LLC distortions were classified based on location (dome, medial crus, lateral crus, or combined) and severity (significant or non-significant). Correlations were assessed with cleft type, PSIO use, and pre-Tajima nasal morphology.</p><p><strong>Results: </strong>LLC distortions were observed in 80% of patients; 45% of these were significant. Dome involvement was most common (60%), especially in incomplete clefts, while combined deformities predominated in complete clefts. Severity was associated with cleft type (P=0.0045), and location was linked to both severity (P<0.001) and laterality (P=0.012). Before tip dissection, unfavorable nostril shape on the non-cleft side appeared in 85.7% of CLA and 80.0% of CLP cases, correlating with cleft type (P<0.001) and location of distortion (P=0.0014). Affected-side morphology predicted both anatomic location (P<0.000001) and severity (P=0.014) of the distortion. PSIO use showed an inverse correlation with the frequency of significant cases (ρ=-0.80).</p><p><strong>Conclusions: </strong>Intraoperative assessment via the modified Tajima incision revealed consistent LLC distortion patterns linked to cleft severity, nasal morphology, and PSIO use.</p>","PeriodicalId":15462,"journal":{"name":"Journal of Craniofacial Surgery","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2025-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145280145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Orthognathic Management of Facial Asymmetry Due to Inactive Idiopathic Condylar Hyperplasia: Accuracy and Morbidity Reduction Without Condylectomy.","authors":"Jean-Thomas Bachelet, Christian Demange","doi":"10.1097/SCS.0000000000012039","DOIUrl":"https://doi.org/10.1097/SCS.0000000000012039","url":null,"abstract":"<p><strong>Background: </strong>Idiopathic condylar hyperplasia (ICH) is a challenging cause of progressive facial asymmetry, particularly when condylar growth becomes inactive. While condylectomy is traditionally recommended in active forms, its necessity in inactive cases remains controversial.</p><p><strong>Objective: </strong>This study aimed to evaluate the accuracy and outcomes of a conservative orthognathic protocol for facial asymmetry secondary to inactive ICH, avoiding condylectomy and using patient-specific digital planning.</p><p><strong>Methods: </strong>Ten patients (aged 19-56) with confirmed inactive ICH were retrospectively analyzed. All underwent orthodontic preparation followed by bimaxillary orthognathic surgery guided by 3D virtual planning and patient-specific surgical guides. Postoperative accuracy was assessed by comparing 1-year CT scans to the preoperative plan. Long-term follow-up was conducted over 5 years.</p><p><strong>Results: </strong>Mean deviations between planned and actual postoperative bone positions were 0.79 mm for the maxilla and 1.33 mm for the mandible. No cases of condylar reactivation or relapse were observed. Orthodontic finishing and physiotherapy were completed in all cases without complications. Surgical time and intraoperative adjustments were minimized, with no significant postoperative morbidity.</p><p><strong>Conclusions: </strong>This study supports the use of a conservative orthognathic protocol in selected cases of inactive ICH, offering precise, stable, and low-morbidity outcomes without requiring condylectomy. Computer-assisted planning and patient-specific instruments allow for accurate translation of surgical simulations into clinical reality. Further studies with larger samples and multicenter designs are encouraged to validate these findings.</p>","PeriodicalId":15462,"journal":{"name":"Journal of Craniofacial Surgery","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145258435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sema Polat, Çağatay Bölgen, Elif İpek Sönmez, Mahmut Öksüzler, Mahmut Tunç, Hazal Duyan Yüksel, Pinar Göker
{"title":"Radiological and Anatomical Evaluation of the Hard Palate in Healthy Adults: A Retrospective Study.","authors":"Sema Polat, Çağatay Bölgen, Elif İpek Sönmez, Mahmut Öksüzler, Mahmut Tunç, Hazal Duyan Yüksel, Pinar Göker","doi":"10.1097/SCS.0000000000012044","DOIUrl":"https://doi.org/10.1097/SCS.0000000000012044","url":null,"abstract":"<p><strong>Objectives: </strong>Due to the hard palate's structure and position, it serves as one of the main structural components in the oral sensorimotor system. This study aimed to examine the hard palate angle, inclination, depth types, and the presence of S-shaped projection in healthy individuals.</p><p><strong>Methods: </strong>Cone-beam computed tomography (CBCT) images of 130 healthy individuals, aged between 18 and 58 years, were retrospectively analyzed. Four parameters, such as hard palate angle (HPA), hard palate inclination (HPI), hard palate depth types (HPDT), and hard palate S-shaped projection, were statistically evaluated.</p><p><strong>Results: </strong>The participants' mean age was 32.57 ± 12.77 years. The HPA was measured at 139.44 ± 7.65 degrees in healthy subjects (138.03 ± 7.00 degrees in females and 141.16 ± 7.75 degrees in males, P = 0.020). When the findings were analyzed, no significant differences were found between genders in terms of HPDT and HPI classification, or the distribution of HPI types and the presence of an S-shaped projection.</p><p><strong>Conclusions: </strong>In this study, the authors evaluated the hard palate angle, inclination, depth types, and the presence of S-shaped projection in healthy individuals. Due to its complex anatomy and central position within the craniofacial region, the hard palate serves as a key landmark, providing important anatomical and clinical insights. The data obtained may assist especially anatomists, dentists, and anesthetists in understanding normal variations and supporting accurate diagnosis and treatment planning.</p>","PeriodicalId":15462,"journal":{"name":"Journal of Craniofacial Surgery","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145258394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yutong Liang, Jinge Li, Xueshang Su, Jun Zhuang, Qi Chen, Ziming Zhang, Qingqian Wei, Jintian Hu
{"title":"Exploring the Therapeutic Potential of Fluorouracil in Addressing Skin Aging and Diseases.","authors":"Yutong Liang, Jinge Li, Xueshang Su, Jun Zhuang, Qi Chen, Ziming Zhang, Qingqian Wei, Jintian Hu","doi":"10.1097/SCS.0000000000012050","DOIUrl":"https://doi.org/10.1097/SCS.0000000000012050","url":null,"abstract":"<p><p>Fluorouracil (5-FU) belongs to the class of fluorouracil compounds and is commonly used as an anticancer drug for various types of cancer treatment. It inhibits tumor growth by blocking DNA synthesis and cell proliferation, thereby exerting anticancer effects. 5-fluorouracil is commonly used in combination with other chemotherapy drugs to enhance its curative effects and can be administered orally or intravenously. Despite its high bioavailability and tissue distribution rate, 5-fluorouracil may also cause a series of adverse reactions including gastrointestinal symptoms (nausea, vomiting, diarrhea) and bone marrow suppression. The skin is not only the largest organ of the human body but also highly susceptible to external environmental factors and internal influences. Many chronic skin conditions, such as eczema, psoriasis, and skin cancer, can impact the health and youthful appearance of the skin. 5-FU can alleviate inflammation by inhibiting cell proliferation, inducing apoptosis, and suppressing DNA synthesis, thereby treating keloids and other skin issues. Maintaining skin health and adopting effective treatment measures for skin diseases are effective ways to delay skin aging. This study explores the therapeutic potential of fluorouracil in addressing skin aging and diseases, providing new ideas for anti-aging treatments.</p>","PeriodicalId":15462,"journal":{"name":"Journal of Craniofacial Surgery","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145258413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nicole C Episalla, Athena Zhang, Esperanza Mantilla-Rivas, Natasha E Shur, Haley S Oh, Maria C Barrera, Albert K Oh, Jason Sentosa, Michael J Boyajian, Gary F Rogers
{"title":"Pharyngeal Arches, Chapter 3: Craniofacial Syndromes.","authors":"Nicole C Episalla, Athena Zhang, Esperanza Mantilla-Rivas, Natasha E Shur, Haley S Oh, Maria C Barrera, Albert K Oh, Jason Sentosa, Michael J Boyajian, Gary F Rogers","doi":"10.1097/SCS.0000000000011974","DOIUrl":"https://doi.org/10.1097/SCS.0000000000011974","url":null,"abstract":"<p><p>Pharyngeal arch development is complex and can result in a wide range of unique head and neck anomalies. Understanding the developmental processes and the related pathoanatomy is essential for clinicians who manage affected patients. This manuscript is the third in a 4-part educational series for plastic surgeons focusing on normal and abnormal pharyngeal arch development. A summary of the etiology and clinical features of each syndrome covered in this manuscript is provided in the Supplemental Table, Supplemental Digital Content 1, http://links.lww.com/SCS/I489 for quick reference.</p>","PeriodicalId":15462,"journal":{"name":"Journal of Craniofacial Surgery","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145258431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}