{"title":"Investigation of the Effects of Ozon and Propolis on the Healing of Bone Defects: An Experimental Study.","authors":"Halil İbrahim Durmuş, Nedim Gunes","doi":"10.1097/SCS.0000000000010722","DOIUrl":"10.1097/SCS.0000000000010722","url":null,"abstract":"<p><strong>Background/aim: </strong>This study explores the effects of ozone and propolis on the healing of critically sized bone defects at both the histologic and molecular levels, and the locations and concentrations of osteopontin and osteonectin during healing; both proteins play roles during bone healing.</p><p><strong>Materials and methods: </strong>This study used 56 adult male Sprague-Dawley rats of an average weight of 350 g, divided into four groups of 14: a control group, a topical ozone group (O), a topical ozone + systemic propolis (O + PO) group, and a systemic propolis group (PO). Seven rats from each group were sacrificed at the end of week 4 and the other seven at the end of week 6. Tissues were subjected to histologic and immunohistochemical examinations in a fixative solution. The results were analyzed using the statistical software package SPSS 23 (Statistical Package for the Social Sciences-IBM). Results were considered significant at the 95% confidence level ( P <0.05).</p><p><strong>Results: </strong>Graft sections were immunostained for osteonectin. Staining was low in the control group but moderate in the other three groups; the differences were significant. The three experimental groups did not differ significantly. Graft sections were also immunostained for osteonectin. At 4 weeks, staining was low in the control group but moderate in the other 3 groups. At 6 weeks, stronger staining was apparent in the 3 experimental groups. At both 4 and 6 weeks, the differences between the control and experimental groups were significantly different, but the differences among the experimental groups were not.</p><p><strong>Conclusion: </strong>The authors' results are compatible with the literature. Ozone and propolis, given separately or together, improved bone healing, increased bone formation, and reduced bone destruction. However, further research is required.</p>","PeriodicalId":15462,"journal":{"name":"Journal of Craniofacial Surgery","volume":" ","pages":"1383-1386"},"PeriodicalIF":1.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142894678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Chenjie Zhao, Tianyi Gu, Xueshan Bai, Jianjian Lu, Li Teng, Liya Yang
{"title":"Comparison of Accuracy in Mandible-First and Maxilla-First Approaches in Bimaxillary Orthognathic Surgery: A Meta-Analysis.","authors":"Chenjie Zhao, Tianyi Gu, Xueshan Bai, Jianjian Lu, Li Teng, Liya Yang","doi":"10.1097/SCS.0000000000011066","DOIUrl":"10.1097/SCS.0000000000011066","url":null,"abstract":"<p><p>This meta-analysis compares the accuracy of mandible-first and maxilla-first approaches in bimaxillary orthognathic surgery to improve clinical decision-making. A systematic search was performed in PubMed, Web of Science, Embase, and Cochrane databases up to August 2024. The analysis included randomized controlled trials and cohort studies with a minimum of 10 patients. Data extraction followed Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, and pooled effect estimates for continuous outcomes were calculated using weighted mean difference (WMD) with 95% CIs. Heterogeneity was assessed using Cochran I2 and Q statistics, with a random-effect model applied when I2 exceeded 50%. Seven studies involving 316 patients were included. The analysis showed no significant differences in vertical (WMD: -0.05, 95% CI: -0.57 to 0.48, P = 0.86), transverse (WMD: -0.17, 95% CI: -0.43 to 0.09, P = 0.21), and sagittal (WMD: -0.41, 95% CI: -0.98 to 0.15, P = 0.15) surgical errors between the two approaches. Rotational surgical errors were also similar, including pitch (WMD: 0.07, 95% CI: -0.11 to 0.25, P = 0.29), roll (WMD: 0.01, 95% CI: -0.18 to 0.25, P = 0.69), and yaw (WMD: 0.12, 95% CI: -0.56 to 0.81, P = 0.72). The findings suggest that there is no significant difference in surgical accuracy between mandible-first and maxilla-first approaches. Therefore, the choice of sequence should be based on patient-specific factors rather than a presumed advantage of one method over the other. Further research, including large-scale randomized controlled trials, is needed to confirm these results and evaluate long-term outcomes.</p>","PeriodicalId":15462,"journal":{"name":"Journal of Craniofacial Surgery","volume":" ","pages":"e459-e464"},"PeriodicalIF":1.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142949584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Luca Bernardo, Alessandro Visioli, Emanuela Del Giudice, Vittoria Carlotta Magenes, Francesca Casini, Giovanni Chiaffoni, Martina Sandini, Valentina Ansuini, Riccardo Lubrano, Angela Mauro
{"title":"Isolated Temporomandibular Arthritis as Presentation of Juvenile Idiopathic Arthritis.","authors":"Luca Bernardo, Alessandro Visioli, Emanuela Del Giudice, Vittoria Carlotta Magenes, Francesca Casini, Giovanni Chiaffoni, Martina Sandini, Valentina Ansuini, Riccardo Lubrano, Angela Mauro","doi":"10.1097/SCS.0000000000011000","DOIUrl":"10.1097/SCS.0000000000011000","url":null,"abstract":"<p><p>Involvement of the temporomandibular joint (TMJ) in patients with juvenile idiopathic arthritis (JIA) has been increasingly reported, affecting up to 87% of cases. This involvement generally occurs after the diagnosis of JIA has been established; however, in the authors' cases, as in a few others documented in the literature, patients presented with isolated TMJ arthritis as the sole joint involvement. The authors performed a narrative literature review on TMJ involvement in JIA and reported 2 cases that presented with isolated TMJ arthritis as the initial manifestation of JIA. Although isolated TMJ involvement may be rare, it can lead to severe complications, such as complete loss of TMJ function. Thus, clinicians should be aware of this potential presentation to conduct necessary investigations and provide appropriate treatment.</p>","PeriodicalId":15462,"journal":{"name":"Journal of Craniofacial Surgery","volume":" ","pages":"e422-e425"},"PeriodicalIF":1.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142931928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Complex Scalp Reconstruction in Moyamoya Disease Using Distant Flap After Free Tissue Transfer Failure.","authors":"Rah Yoon Kim, Chang Jun Lee, Sang Oon Baek","doi":"10.1097/SCS.0000000000010879","DOIUrl":"10.1097/SCS.0000000000010879","url":null,"abstract":"<p><p>A preferred option among many surgeons for treating large defects in the head and neck area is reconstruction using autologous tissue, particularly free tissue transfer with microvascular anastomosis. However, some defects cannot be resolved with conventional microvascular techniques or algorithmic approaches. In this case study, a 55-year-old female, who previously underwent bypass surgery for Moyamoya disease, presented with a large scalp defect following surgical necrosis. After initial coverage using a free anterolateral thigh flap, partial necrosis developed, leaving a persistent 2×4 cm² defect. To resolve this, a distant thenar flap was harvested and successfully used for reconstruction. Postoperatively, the patient exhibited full recovery without complications. This case highlights the effectiveness of distant flap techniques, particularly when microvascular surgery is not feasible or has failed. The historical significance and continued applicability of distant flaps in challenging cases underscore their importance in the reconstructive armamentarium.</p>","PeriodicalId":15462,"journal":{"name":"Journal of Craniofacial Surgery","volume":" ","pages":"e390-e392"},"PeriodicalIF":1.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143006225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Gonzalo Ruiz-de-Leon, Carlos Navarro-Cuellar, Manuel Tousidonis
{"title":"Maxillary Jaw-in-a-Day: The Role of Point-of-Care Manufacturing and Implant Stability Quotient in Centrofacial Chondrosarcoma.","authors":"Gonzalo Ruiz-de-Leon, Carlos Navarro-Cuellar, Manuel Tousidonis","doi":"10.1097/SCS.0000000000011142","DOIUrl":"10.1097/SCS.0000000000011142","url":null,"abstract":"<p><p>Chondrosarcoma is a rare malignant tumor of epithelial origin, with fewer than 0.1% of cases affecting the nasal septum. Maxillofacial oncological surgery presents significant challenges, particularly in maxillary reconstruction, often requiring complex rehabilitation. This case report describes the use of point-of-care manufacturing, customized cutting guides, and 3D printing technology for fibular-free flap reconstruction and guided dental implant placement in a 42-year-old male with centrofacial nasal chondrosarcoma. After a bilateral maxillectomy, continuity across the maxillomalar buttress was restored using a fibular-free flap and a patient-specific reconstruction plate. Immediate implant placement and prosthetic loading were performed, supported by the Implant Stability Quotient (ISQ), which provided objective data on implant stability, allowing immediate loading due to high primary stability. The integration of point-of-care manufacturing and ISQ enhances precision in guided surgery, facilitating quicker functional and esthetic rehabilitation, and offering faster recovery and improved quality of life for oncological patients requiring complex maxillofacial reconstruction.</p>","PeriodicalId":15462,"journal":{"name":"Journal of Craniofacial Surgery","volume":" ","pages":"e481-e483"},"PeriodicalIF":1.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143414391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Recurrent Giant Subcutaneous Tumor in Juvenile Hyaline Fibromatosis.","authors":"Xinyao Wang, Jia Wei, Xiaoqiang Wang","doi":"10.1097/SCS.0000000000011062","DOIUrl":"10.1097/SCS.0000000000011062","url":null,"abstract":"<p><p>This case report presents a 5-year-old boy diagnosed with juvenile hyaline fibromatosis (JHF), an extremely rare autosomal recessive disorder characterized by the abnormal accumulation of collagen. The patient exhibited a recurrent giant subcutaneous tumor measuring 20 cm in diameter, along with multiple tumors in the oral cavity, gingiva, and joints, leading to significant facial deformity and functional impairments. Previous surgeries at ages 1 and 2 for tumor removal resulted in recurrence. Surgical intervention was performed to excise the large tumor and alleviate symptoms. Pathologic analysis confirmed the diagnosis of JHF. This case highlights the challenges in managing JHF and the need for multidisciplinary approaches in treatment.</p>","PeriodicalId":15462,"journal":{"name":"Journal of Craniofacial Surgery","volume":" ","pages":"e473-e475"},"PeriodicalIF":1.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143441047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Secondary Cleft Rhinoplasty Using Circumferential Alar Rim Cartilage Graft: Surgical Technique and Morphometric Study.","authors":"S Moltaji, A Wang, F Cardemil, J A Fialkov","doi":"10.1097/SCS.0000000000011086","DOIUrl":"10.1097/SCS.0000000000011086","url":null,"abstract":"<p><strong>Background: </strong>Achieving symmetry in secondary cleft rhinoplasty is challenging even for the most skilled surgeon. The authors present their technique and outcomes of using a circumferential alar rim graft to relocate the cleft-sided anterior ala superiorly and anteriorly. The graft, under tension, is anchored to the septum at one end and the intermediate crus at the other, exerting an upward and anteriorly projected force.</p><p><strong>Methods: </strong>Adult patients with unilateral cleft lip and palate who underwent secondary cleft rhinoplasty between 2013 and 2022, using the circumferential alar rim graft (CARG) technique, were included. Standardized photographs were used to obtain morphometric measurements. Ratios of cleft side to non-cleft side nostril height, width, and area, as well as tip projection, were compared preoperatively and postoperatively. Wilcoxon signed-rank test evaluated statistically significant differences between the measurements.</p><p><strong>Results: </strong>Twenty-seven patients were included, with a mean age of 26.9 years (range 19-42). Most were female (n=18), with left-sided clefts (n=20). Nostril height symmetry, expressed as a ratio of cleft side over the non-cleft side (with 1 being perfect symmetry), improved significantly by 10% ( P <0.001). Nostril width symmetry improved significantly by 22% ( P =0.012), and nostril area symmetry improved significantly by 21% ( P =0.008). When preoperative and postoperative subnasale-pronasale over inter-alar width ratios were compared, tip projection was found to increase significantly by 10% ( P =0.029). Five CARG-related complications occurred, including 2 graft detachments and 1 graft fracture.</p><p><strong>Conclusions: </strong>Using a circumferential alar rim graft in secondary cleft rhinoplasty significantly improved nasal symmetry in terms of nostril height and area.</p>","PeriodicalId":15462,"journal":{"name":"Journal of Craniofacial Surgery","volume":" ","pages":"1137-1142"},"PeriodicalIF":1.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143542125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Matthew A Brett, Natalie M Plana, Andrea Torroni, Roberto L Flores
{"title":"Utilization of Bonney's Blue Dye as an Adjunct to Orthognathic Surgery Augmented by Virtual Surgical Planning.","authors":"Matthew A Brett, Natalie M Plana, Andrea Torroni, Roberto L Flores","doi":"10.1097/SCS.0000000000011192","DOIUrl":"10.1097/SCS.0000000000011192","url":null,"abstract":"<p><p>Virtual surgical planning (VSP) has revolutionized orthognathic and craniomaxillofacial surgeries by enabling precise 3-dimensional analysis, detailed osteotomy planning, and custom fabrication of surgical guides and fixation hardware. However, the visualization of registration holes-critical for accurate plate fixation-remains challenging, especially in a blood-filled surgical field. This paper presents a novel technique to enhance the visibility of registration holes using Bonney's blue dye. The technique involves injecting micro-aliquots of Bonney's blue dye (a mixture of crystal violet and brilliant green) into the registration holes before performing osteotomies. This approach ensures that the holes remain clearly marked despite potential visual contamination in the surgical field. The dye helps to identify screw placements and align patient-specific fixation plates more accurately. The proposed method addresses common difficulties in aligning registration holes with patient-specific plates during surgery. Bonney's blue dye provides a clear contrast against the bone, making the registration holes more visible and easier to locate. This improvement is particularly advantageous in a bloody surgical field and benefits less experienced surgeons by offering a straightforward solution to enhance accuracy and efficiency. The technique can also reduce overall operative time by minimizing the time spent locating and aligning the registration holes. Utilizing Bonney's blue dye in virtual surgical planning significantly improves the visibility and alignment of registration holes in orthognathic surgeries. This simple, cost-effective method enhances surgical precision and efficiency and can be applied to other computer-assisted surgical procedures in craniofacial surgery.</p>","PeriodicalId":15462,"journal":{"name":"Journal of Craniofacial Surgery","volume":" ","pages":"1365-1367"},"PeriodicalIF":1.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143624901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Evaluation of the Awareness and Knowledge Levels of Dentists Regarding Bisphosphonates and Bisphosphonate-Related Jaw Necrosis.","authors":"Ridvan Guler, Emine Yalcin","doi":"10.1097/SCS.0000000000010870","DOIUrl":"https://doi.org/10.1097/SCS.0000000000010870","url":null,"abstract":"<p><p>Bisphosphonates are used in the treatment of osteoporosis, bone metastases, and metabolic bone diseases. Long-term use of bisphosphonates increases the risk of osteonecrosis in patients undergoing dental surgery. This study aimed to evaluate dentists' knowledge about bisphosphonates and bisphosphonate-related osteonecrosis of the jaw (BRONJ) and their treatment approaches in patients using oral and intravenous bisphosphonates. In this study, a 25-question questionnaire was applied to dentists working in different institutions regarding their knowledge and experience about bisphosphonates and BRONJ, and treatment approaches for different surgical procedures in patients using bisphosphonates. The obtained data were statistically analyzed and evaluated. In total, 90.5% of the dentists identified osteoporosis, 79.8% identified bone metastases, 52.4% identified osteitis deformans, and 39.3% identified multiple myeloma as conditions in which bisphosphonates are used, thus answering correctly in a significant proportion. When participants were asked about treatment options according to the stages of BRONJ, participation in the \"I'm not sure\" option increased as the stages progressed, indicating that dentists were not sufficiently familiar with the treatments for different stages of BRONJ. In total, 88.5% of the participants stated that when they see an exposed bone area in patients they examine, they consider bisphosphonate use as a possible cause. There was a statistically significant difference between dentists with and without prior BRONJ experience regarding their ages (P=0.039) and years of practice (P=0.001). There was a statistically significant difference between dentists with and without BRONJ experience regarding whether they inquired about bisphosphonate use (P=0.001). It was found that dentists have serious deficiencies in knowledge regarding bisphosphonates, their side effects, and treatment approaches for patients using bisphosphonates. Increasing dentists' knowledge and awareness of this issue would help reduce the risk of developing BRONJ.</p>","PeriodicalId":15462,"journal":{"name":"Journal of Craniofacial Surgery","volume":"36 4","pages":"e376-e382"},"PeriodicalIF":1.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144215980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Diana Russo, Pierluigi Mariani, Luca Bifulco, Simone Ferrara, Marco Cicciù, Luigi Laino
{"title":"Three-dimensional Morphometric Analysis of the Effectiveness of Kinesio Taping on Postoperative Discomfort Following Mandibular Third Molar Surgery: A Prospective Randomized Split-mouth Study.","authors":"Diana Russo, Pierluigi Mariani, Luca Bifulco, Simone Ferrara, Marco Cicciù, Luigi Laino","doi":"10.1097/SCS.0000000000010756","DOIUrl":"10.1097/SCS.0000000000010756","url":null,"abstract":"<p><p>This study investigates the efficacy of Kinesio taping (KT) in reducing postoperative discomfort, including edema, trismus, and pain, following mandibular third molar extraction. A prospective randomized split-mouth design was employed, involving 7 patients with impacted mandibular third molars. KT was applied immediately postsurgery, and outcomes were assessed on the third and seventh postoperative days using a Visual Analog Scale (VAS) for pain, 3D morphometric analysis for swelling, and caliper measurements for trismus. Results showed significant reductions in pain, swelling, and trismus on the KT-treated side compared with the control side. The most notable differences were observed on day 7, where KT demonstrated superior effectiveness in alleviating symptoms. The control group showed improvement over time, but the KT-treated group experienced faster and more pronounced recovery. In conclusion, KT proved to be a safe and effective method for improving postoperative recovery following mandibular third molar surgery, offering a low-cost, accessible option to enhance patient comfort and quality of life.</p>","PeriodicalId":15462,"journal":{"name":"Journal of Craniofacial Surgery","volume":" ","pages":"1387-1391"},"PeriodicalIF":1.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142894860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}