Journal of Craniofacial Surgery最新文献

{"title":"Hearing Loss in 5-Year-Old and 12-Year-Old Patients With a Cleft Palate and Evaluating Standardized Assessment Methods.","authors":"Philip van der Goes, Saranda Ombashi, Sarah Versnel, Jantien Vroegop, Marc van der Schroeff","doi":"10.1097/SCS.0000000000011407","DOIUrl":"https://doi.org/10.1097/SCS.0000000000011407","url":null,"abstract":"<p><p>This study describes the results of hearing assessment in patients with cleft palate with or without cleft lip (CP±L) enrolled in the International Consortium for Health Outcome Measures set for cleft lip and palate (ICHOM set). Other cleft initiatives were examined to provide an overview of the hearing assessment used. Data were analyzed from 390 patients with CP±L, aged 5 or 12 years, who were followed up according to the ICHOM set between 2016 and 2023. Statistical analysis evaluated pure-tone average (PTA) differences by age, cleft phenotype, sex, ventilation tube (VT) insertion, isolated CP±L, syndromes associated with hearing loss (HL), and syndromes with unknown associations with HL. Other cleft initiatives were reviewed to compare hearing assessments. The median PTA was higher in 5-year-olds (15.31 dB HL; IQR 10.0-27.5) than in 12-year-olds (10.0 dB HL; IQR 6.9-16.7; P<0.001). Patients with VT insertions had worse thresholds (median 12.50 dB HL; IQR 8.1-24.0) compared with those without (median 9.4 dB HL; IQR 5.8-13.8; P<0.001). Patients with syndromes associated with HL showed worse hearing thresholds (median 17.81 dB HL) than isolated CP±L (median 11.25 dB HL). Conductive hearing loss (CHL) was found in 35% of 5-year-olds and 15% of 12-year-olds. To improve the ICHOM set and align with other initiatives, assessments at additional frequencies (0.25-8 kHz), air and bone conduction, tympanometry, and evaluations around age 3 are recommended.</p>","PeriodicalId":15462,"journal":{"name":"Journal of Craniofacial Surgery","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143968258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Temporobasal Hemorrhage Following Retrosigmoid Resection of Cerebellopontine Angle Meningioma: A Rare Surgical Complication.","authors":"Qiang Chen, Lang Chen","doi":"10.1097/SCS.0000000000011416","DOIUrl":"https://doi.org/10.1097/SCS.0000000000011416","url":null,"abstract":"<p><p>The authors aim to report a rare case of supratentorial temporobasal hemorrhage occurring after resection of a cerebellopontine angle (CPA) meningioma through a retrosigmoid approach and to elucidate the underlying mechanisms of this postoperative complication while offering surgical insights to prevent its occurrence. In the present study, the authors report a case of a 52-year-old female patient admitted for \"dizziness for 1 year, exacerbated over the past 3 months\". Preoperative magnetic resonance imaging (MRI) revealed a 2.5 cm×2 cm ×2 CPA meningioma, classified as Simpson grade I, attached to the right petrous bone and tentorium cerebelli. The patient underwent gross total resection (GTR) through a retrosigmoid approach. Intraoperatively, tumor invasion into the tentorium was found, with slow oozing from the tentorial layer during resection, controlled by repeated electrocoagulation. Three hours postoperatively, the patient's consciousness deteriorated. Emergency computed tomography (CT) revealed a massive supratentorial temporobasal hemorrhage, prompting urgent hematoma evacuation. The patient fully recovered without neurological sequelae after hematoma evacuation. The authors propose that excessive electrocoagulation during resection may have impaired temporobasal venous drainage, leading to hemorrhage. This case illustrates a novel mechanism underlying surgical hemorrhagic complications and underscores the importance of hemostasis techniques during resection of the tumor within the tentorial layer, as well as the protection of temporobasal venous drainage.</p>","PeriodicalId":15462,"journal":{"name":"Journal of Craniofacial Surgery","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144009900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the Relationship Between Altmetric Attention Scores and Citations: A Study Based on Articles Published in the Journal of Craniofacial Surgery.","authors":"Burak Erkmen, Yusuf Muhammed Durna, Şamil Şahin, Yaşar Kemal Duymaz, İlhan Bahşi","doi":"10.1097/SCS.0000000000011420","DOIUrl":"https://doi.org/10.1097/SCS.0000000000011420","url":null,"abstract":"<p><strong>Objective: </strong>This study investigates the relationship between Altmetric Attention Scores (AAS) and traditional citation metrics for articles published in the Journal of Craniofacial Surgery between 1990 and 2025. Bibliometric analyses are commonly used to assess the impact and productivity of scientific studies. However, the growing role of social media platforms in academic dissemination has led to the emergence of alternative metrics like AAS, which measure online engagement and attention.</p><p><strong>Methods: </strong>A search conducted on the Dimensions website identified 17,232 articles published during the study period. Of these, 228 articles had an AAS of 5 or higher. The highest AAS values were predominantly associated with articles published in the last decade. Metrics such as the Field Citation Ratio (FCR) and Relative Citation Ratio (RCR) were analyzed alongside AAS values. The top 10 articles with the highest AAS showed that there was no statistical correlation between AAS and traditional citation metrics, including citation count, FCR, and RCR.</p><p><strong>Results: </strong>The findings indicate that although altmetric analyses provide valuable insights into the online visibility of articles, they should be used in conjunction with traditional bibliometric methods for a comprehensive evaluation of scholarly impact. The study also underscores the need for further research to understand the interplay between social media engagement and academic citations.</p><p><strong>Conclusions: </strong>This research contributes to the ongoing discourse on the utility of altmetrics in complementing traditional metrics and provides insights for evaluating the multifaceted impact of scientific publications.</p>","PeriodicalId":15462,"journal":{"name":"Journal of Craniofacial Surgery","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143973512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hairline Polycaprolactone Injections for Facial Lifting: An Anatomical-Based Approach.","authors":"Isaac Kai Jie Wong, Jovian Wan, Kyu-Ho Yi","doi":"10.1097/SCS.0000000000011365","DOIUrl":"https://doi.org/10.1097/SCS.0000000000011365","url":null,"abstract":"<p><p>Polycaprolactone (PCL) is a bioresorbable, biostimulatory polymer offering unique advantages in non-surgical facial rejuvenation, including immediate tissue support and long-term collagen stimulation. This manuscript introduces a novel zone-based framework to guide the use of PCL in achieving facial lifting and contouring. The approach segments the face into 3 zones: zone 1 (red) for lateral lifting, zone 2 (blue) for volumization, and zone 3 (green) for 3-dimensional enhancement, tailored to Asian facial anatomy. By targeting zone 1, the lateral hairline, PCL injections can create a lifting effect by strengthening ligamentous structures and redistributing facial tension. Two split-face case studies demonstrate the efficacy and safety of this approach in addressing midface sagging, nasolabial folds, and jowling, avoiding the facial overfilled syndrome. This innovative technique offers a safe, effective, and anatomically informed method for facial rejuvenation.</p>","PeriodicalId":15462,"journal":{"name":"Journal of Craniofacial Surgery","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144012421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Novel Surgical Technique for Bilateral Reconstruction of the Philtrum and Cupid's Bow in Secondary Unilateral Cleft Lip Deformities.","authors":"Hongru Zhou, Leheng Jiang, Congxiao Zhu, Haoyue Guo, Ningbei Yin","doi":"10.1097/SCS.0000000000011426","DOIUrl":"https://doi.org/10.1097/SCS.0000000000011426","url":null,"abstract":"<p><strong>Background: </strong>Secondary deformities involving the philtrum and Cupid's bow often persist in cleft lip and palate patients, leading to compromised aesthetic outcomes. This study aimed to evaluate a novel bilateral surgical approach for addressing unilateral secondary cleft lip deformities and improving philtral column and Cupid's bow prominence.</p><p><strong>Materials and methods: </strong>This study included 16 patients with unilateral cleft lip deformities who underwent this procedure from June 2018 to June 2024, with a mean follow-up of 12 months (range 6-36). Three-dimensional stereophotogrammetry was used to assess philtral projection and lip height before and after surgery. Expert evaluations and patient satisfaction scores were collected.</p><p><strong>Results: </strong>Three-dimensional measurements revealed significant improvements in philtral column and Cupid's bow projection, with reduced asymmetry (P < 0.01). Both sides of the philtrum exhibited enhanced projections, reducing side-to-side differences (P < 0.01), and philtrum height increased on the cleft side (P = 0.017), demonstrating enhanced symmetry. Expert assessments yielded an average overall score of 4.2, indicating a generally \"satisfactory\" postoperative outcome. Patient-reported satisfaction was 3.1 out of 4.</p><p><strong>Conclusions: </strong>This technique innovatively introduces the concept of bilateral surgical correction to address secondary unilateral cleft lip deformities. Enhanced symmetry, high patient satisfaction, and minimal complications underscore its potential to safely achieve refined, balanced upper lip contours.</p>","PeriodicalId":15462,"journal":{"name":"Journal of Craniofacial Surgery","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144003680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative Analysis of the Lateral and Superior Cerebellar Keyhole Approach and Subtemporal Keyhole Approach to the Ventrolateral Brainstem Regions: A Different Perspective.","authors":"Bingwei Song, Jianwei Liu, Hengzhu Zhang, Yong Zhen, Qing Wang, Zhemin Ding, Xiaojie Lu","doi":"10.1097/SCS.0000000000011378","DOIUrl":"https://doi.org/10.1097/SCS.0000000000011378","url":null,"abstract":"<p><strong>Objective: </strong>To compare the exposure and working distances of lateral and superior cerebellar keyhole approach (LSCKA) with subtemporal keyhole approach (STKA) and Kawase approach (KA) in the ventrolateral brainstem regions.</p><p><strong>Methods: </strong>The LSCKA was performed in 6 cadaveric heads (12 sides). The STKA was performed in another 6 cadaveric heads (12 sides), and then the KA was performed. The related anatomic structures for the 3 approaches were observed by a 0-degree endoscope and microscope. The distances of exposure and operation were measured and analyzed using a dedicated ruler and software ImageJ.</p><p><strong>Results: </strong>The exposure margin provided by the microscope is equated to the surgical margin. The LSCKA gained greater superior and inferior exposure margin of the ventrolateral brainstem region created by the microscope than the STKA and KA (all P<0.001). When the anatomic structures of the ventrolateral brainstem region were observed and measured using the 0 endoscope, the LSCKA increased the superior and inferior exposure and working distances of the ventrolateral brainstem region, and also increased dorsal working distances, but decreased ventral exposure distance compared with the STKA and KA. In addition, the LSCKA provided fewer working distances in the ventral brainstem region than the KA.</p><p><strong>Conclusions: </strong>The LSCKA offers greater advantages in the inferior and superior brainstem regions than the STKA and KA, but limitations in the ventral brainstem region than the KA. The LSCKA is a powerful window into lesions predominantly located in the posterior fossa with extension into the middle fossa.</p>","PeriodicalId":15462,"journal":{"name":"Journal of Craniofacial Surgery","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144020622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Safety and Efficacy of Autologous Calvarial Graft Reconstruction for Large Cranial Defects in Pediatric Patients.","authors":"Esperanza Mantilla-Rivas, Kathleen N Johnson, Perry S Bradford, Robert F Keating, Athena Zhang, Chenyu Liu, Nathanael S Oh, Monica Manrique, Albert K Oh, Gary F Rogers","doi":"10.1097/SCS.0000000000011398","DOIUrl":"https://doi.org/10.1097/SCS.0000000000011398","url":null,"abstract":"<p><p>Reconstruction of cranial defects using autologous calvarial grafts offers long-term advantages over alloplastic alternatives, especially in pediatric patients. However, the effectiveness of this method has been questioned for larger defects. This study evaluates outcomes after cranial reconstructions with fresh autologous calvarial grafts in pediatric patients. Medical records of pediatric patients who underwent cranioplasty with fresh autologous calvarial grafts at our institution over 10 years (2012-2022) were reviewed. The area of the bone defect and degree of postoperative osseus healing was determined clinically or by using 3-dimensional computed tomography (CT) when available. Secondary outcomes, including complications, unanticipated readmissions, and reoperation rates, were assessed. Twenty-seven patients, with a median age of 9.8 years at the time of reconstruction, were included. There were no infections, cerebrospinal fluid leaks, readmissions, or reoperations reported. At a median of 51 months postoperatively, only one patient (3.7%) exhibited a clinically appreciable bone defect. Postoperative CT, obtained at a median of 24 months, was available for thirteen patients (48.1%). These patients had a median bone healing rate of 84.1%. Incomplete bone healing correlated with larger initial defects (median: 24; IQR: 20-40.6 cm2 vs. 260.4; IQR: 198-302 cm2; P=0.002] and a higher number of previous craniofacial procedures (P=0.032). Cranioplasty using fresh autologous bone graft is safe and effective, with a median clinical bone healing rate of 96.3% and radiographic bone healing rate of 84.1%. Patients with a higher number of previous cranial procedures and a larger initial defect size are at higher risk of incomplete bone healing.</p>","PeriodicalId":15462,"journal":{"name":"Journal of Craniofacial Surgery","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144012423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patient-Reported Outcome Measures (PROM) After Endoscopic and Open Correction of Sagittal Suture Synostosis-In Comparison With Surgeons' and Lay Persons' Assessment.","authors":"Matthias Schulz, Maria Renninger, Gesa Cohrs, Valentina Pennacchietti, Ahmed El-Garci, Andreas Schaumann, Tobias Ebker, Ulrich-Wilhelm Thomale","doi":"10.1097/SCS.0000000000011356","DOIUrl":"https://doi.org/10.1097/SCS.0000000000011356","url":null,"abstract":"<p><strong>Objective: </strong>The presented study compares the qualitative subjective outcome assessment after open and endoscopic-assisted correction of sagittal suture synostosis by 3 evaluating groups.</p><p><strong>Methods: </strong>The assessment of the postoperative outcome of 3 groups-parents, surgeons and lay persons (\"neutrals\")-was evaluated by answering items of a patient-reported outcome measurement (PROM) questionnaire. Furthermore, a subjective outcome assessment was performed by the group of surgeons with the ERN CRANIO photo score for sagittal synostosis.</p><p><strong>Results: </strong>The PROM assessment of all 3 evaluating groups demonstrated a significant reduction of the severity of the sagittal synostosis phenotype after open and endoscopic-assisted correction without any difference between both techniques. Although there was a significant correlation of the outcome assessment of all 3 groups, parents scored the postoperative phenotype significantly better than the group of surgeons and \"neutrals\". The assessment by the 3 evaluating groups showed a significant correlation, which was highest between the groups of surgeons and the groups of \"neutrals\" Correspondingly, there was a significant improvement of the ERN CRANIO photo score by the group of surgeons without any difference between both operative techniques and a high correlation between the PROM and the ERN Cranio photo score assessment by the surgeons.</p><p><strong>Conclusion: </strong>Both open and endoscopic-assisted correction of sagittal suture synostosis provided significant improvement of the phenotype in the PROM assessment of parents, surgeons and \"neutrals\" without difference between the 2 operative techniques. The combination of PROM assessment by parents and the ERN CRANIO photo score evaluation performed by health care professionals offers an effective assessment for subjective qualitative judgment of the severity of sagittal synostosis.</p>","PeriodicalId":15462,"journal":{"name":"Journal of Craniofacial Surgery","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144026803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Compact Silicon Carbide Bio Glass Graft Material for Bone Augmentation.","authors":"Randa Alfotawi","doi":"10.1097/SCS.0000000000011421","DOIUrl":"https://doi.org/10.1097/SCS.0000000000011421","url":null,"abstract":"<p><strong>Background: </strong>The significant clinical demand for bone augmentation and the reported complications with the current biomaterials make it an essential area of research. Using a rat model, the study explores the role of dense bioactive silicon carbide (SiC) ceramic and evaluates its integration to long bone.</p><p><strong>Materials and methods: </strong>SiC cylinders were made at the dimension of 5×3×5 mm using SiC particles size 40 μm and were fabricated by exposing SiC particles to 15% NaOH for 15 minutes before they were mixed with the smaller SiC particles. Thereafter, they were heated to 650 °C for 5 hours. The biocompatibility and osteogencity of the SiC-compacted cylinders were then evaluated in vitro. After being cultured on the surface of SiC compact cylinders, mesenchymal stromal cells (MSCs) were evaluated for cell viability and differentiation using semi-quantitative RT-PCR, quantitative Alkaline Phosphatase (ALP) expression, and scanning electron microscopy. The material was then tested in vivo on 18 rats. After 12 weeks, the transplanted tissues were removed and subjected to mechanical, radiograph, and histologic analysis, including immunohistochemistry for osteopontin and S100.</p><p><strong>Results: </strong>Osteogenic potential and SiC biocompatibility were noted. More radio-opacity that was indistinguishable from the cortical native bone was observed on cone-beam computed tomography for the samples; no radiolucent space was visible, indicating integration with bone. In comparison to the control group, the grafted long bone group exhibited a statistically significant greater Maximum Load and a high mechanical flexural strength compared with non-operated bone (P<0.001). Histologically, SiC integration was observed; mixed lamellar and woven bone is shown in the native bone, and osteoblastic cells were present at the edges of SiC. This was verified by positive osteopontin staining at the interface area. Moreover, positive staining at the interface area for S100 antibody indicates the innervation of the newly formed bone.</p><p><strong>Conclusion: </strong>The tested construct made of compact SiC has potential to osteointegration into native bone, making it a suitable material for bone augmentation.</p>","PeriodicalId":15462,"journal":{"name":"Journal of Craniofacial Surgery","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144011344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sonographic Evaluation of the Submandibular Region and Perforators Mapping Before Harvesting a Submental Flap May Reduce Vascular-Related Complications.","authors":"Dominik A Walczak, Jakub Opyrchał, Łukasz Krakowczyk, Maciej Grajek, Adam Maciejewski, Cezary Szymczyk, Daniel Bula","doi":"10.1097/SCS.0000000000011440","DOIUrl":"https://doi.org/10.1097/SCS.0000000000011440","url":null,"abstract":"<p><p>The submental flap (SF) may serve as an alternative to free flap microvascular reconstruction in the head and neck region for appropriately selected patients. However, despite its apparent simplicity, the SF can be associated with a significant incidence of vascular complications affecting the transferred tissues. The aim of this study was to evaluate the usefulness of preoperative color Doppler ultrasonography (CDU) in planning the submental flap. A total of 62 patients with oral cavity cancers who underwent reconstruction using the submental flap were included. In the first group, perforators and the vascular course were assessed preoperatively using CDU. The second group comprised retrospectively selected patients who did not undergo preoperative perforator mapping. Perforators were most commonly located lateral to the digastric muscle. We observed a lower overall incidence of flap perfusion disorders in patients who underwent CDU evaluation (6 versus 1; P=0.105). Moreover, these patients required fewer reoperations. In conclusion preoperative sonographic assessment of the submandibular region should be performed on all patients for whom SF reconstruction is planned. This approach enables precise identification of vessels and their trajectories, facilitating safer and more efficient flap elevation.</p>","PeriodicalId":15462,"journal":{"name":"Journal of Craniofacial Surgery","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143968090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}