Journal of Craniofacial Surgery最新文献

{"title":"Acute Upper Extremity Deep Vein Thrombosis Following Extensive Nasal Reconstruction Surgery: A Case Report.","authors":"Yuan Chen, Ronghao Ouyang, Hang Zhang, Jiaqi Yao, Yingzi Li, Hongli Chai, Jintian Hu","doi":"10.1097/SCS.0000000000011242","DOIUrl":"https://doi.org/10.1097/SCS.0000000000011242","url":null,"abstract":"<p><p>Upper extremity deep vein thrombosis (DVT) is an uncommon complication in plastic surgery, with a high potential for misdiagnosis due to its rarity. This case report describes a 21-year-old male who developed upper extremity DVT after a comprehensive nasal reconstruction surgery. Despite an initially uneventful procedure, the patient presented with significant pain and swelling in his right arm on the first postoperative day. Doppler ultrasound confirmed acute thrombosis in the brachial, ulnar, and radial veins. Timely anticoagulation therapy led to symptom resolution and thrombus clearance. This case underscores the importance of early recognition and management of upper extremity DVT in postoperative patients to prevent complications. Clinicians should maintain a high index of suspicion for DVT in patients with postoperative extremity pain and swelling, regardless of its perceived rarity.</p>","PeriodicalId":15462,"journal":{"name":"Journal of Craniofacial Surgery","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143730219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Systematic Review of the Application of Artificial Intelligence in Keloid.","authors":"Jingyang Zhou, Runmeng Cui, Lin Lin","doi":"10.1097/SCS.0000000000011259","DOIUrl":"https://doi.org/10.1097/SCS.0000000000011259","url":null,"abstract":"<p><p>Aberrant skin healing after trauma sometimes causes substantial physical and psychological problems for patients with keloid. Therefore, it is particularly important to understand the pathogenic process, find additional risk factors, investigate novel, comprehensive, and accurate therapeutic options, and set up an efficient workflow for accurate prognostic prediction of keloid. Artificial intelligence technology, which has made significant strides in recent years, maybe a good option for achieving the aforementioned objectives. On the basis of actual clinical big data, it can perform sufficiently thorough data mining and quickly and accurately anticipate diseases, providing us with new ideas and insights for the keloid. This article seeks to do a thorough analysis of the recently published literature that looks at the application of artificial intelligence in keloid holistically to serve as a reference and inspiration for future research in this field.</p>","PeriodicalId":15462,"journal":{"name":"Journal of Craniofacial Surgery","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143730202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the Impact of 731 Immunophenotypes on Alopecia Areata Risk: A Mendelian Randomization Analysis With Plasma Metabolites as Mediators.","authors":"Cuimei Wang, Chong Wu, Hongwei Liang","doi":"10.1097/SCS.0000000000011291","DOIUrl":"https://doi.org/10.1097/SCS.0000000000011291","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to delineate the causal relationship between immunophenotypes and alopecia areata (AA) and to assess the intermediary role of plasma metabolites.</p><p><strong>Methods: </strong>The authors utilized bidirectional Mendelian randomization (MR) to parse the causal associations between 731 immunophenotypes and AA using genome-wide association study (GWAS) summary statistics from 767 cases and 394,105 controls. A 2-step MR strategy was adopted to quantify the influence of 1400 plasma metabolites on AA through their impacts on immunophenotypes.</p><p><strong>Results: </strong>The MR findings indicated that an elevated genetically predicted expression of HLA DR on CD14+ CD16- monocytes correlates with an augmented AA risk [Odds Ratio (OR) = 1.199, 95% CI = 1.079-1.332, P = 0.0007]. This association was primarily estimated using the inverse variance weighted (IVW) method. In contrast, the data did not provide robust evidence supporting an influence of genetically predicted AA on the expression of HLA DR in these monocytes (OR = 1.008, 95% CI = 0.989-1.028, P = 0.401). The mediating effect of glycochenodeoxycholate glucuronide on the immunophenotype-AA relationship was quantified at 6.5%, whereas arachidoylcarnitine (C20) mediated 4.7% of the effect.</p><p><strong>Conclusion: </strong>The analysis substantiates a causal link between HLA DR expression on CD14+ CD16- monocytes and AA, with partial mediation by arachidoylcarnitine (C20) and glycochenodeoxycholate glucuronide. The principal mechanisms by which HLA DR affects AA are yet to be fully elucidated, necessitating further investigations to uncover additional mediators and risk factors.</p>","PeriodicalId":15462,"journal":{"name":"Journal of Craniofacial Surgery","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143729954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diced Cartilage Graft for Correction of Alar Base Asymmetry in Post Unilateral Cleft-Lip Nose Deformity.","authors":"Magdy Ahmed Abd-Al Moktader, Mohamed Osama Ouf, Ahmed Khaled Noweir","doi":"10.1097/SCS.0000000000011269","DOIUrl":"https://doi.org/10.1097/SCS.0000000000011269","url":null,"abstract":"<p><strong>Background: </strong>Cleft lip is one of the most common birth defects. Unilateral cleft-lip nose deformity is often complicated by maxillary bone hypoplasia that involves the pyriform aperture.</p><p><strong>Aim: </strong>To evaluate the outcome of using diced cartilage graft to correct asymmetry in the alar base postunilateral cleft lip nasal deformity through the analysis of preoperative and postoperative 3D CT volume rendering images, clinical assessments, and photogrammetry.</p><p><strong>Patients and methods: </strong>This was a case series clinical trial conducted between April 2021 and April 2024 on 40 patients with post cleft-lip nose alar base asymmetry (treated by injection of diced cartilage for alar base asymmetry in addition to rhinoplasty). The patients were evaluated preoperatively and postoperatively using 3D CT volume rendering images processed using specialized programs (RadiAnt DICOM Viewer), clinical assessments, and photogrammetry.</p><p><strong>Results: </strong>Forty unilateral cleft lip patients were included. There was a statistically highly significant difference between preoperative and postoperative evaluations among the studied patients regarding nostril height, alar base position, vertical lip length, nasal base inclination angle, and alar base width. In all, 10% of patients were unsatisfied, 82.5% were satisfied, and 7.5% were very satisfied. In all, 12.5% of patients had alar base asymmetry, 5% of patients had nostril asymmetry, and 82.5% of patients did not complain of asymmetry. Five percent of patients had a poor functional assessment, while 95% had a good functional assessment.</p><p><strong>Conclusion: </strong>The use of diced cartilage showed excellent surgical outcomes in correcting alar base asymmetry in postunilateral cleft-lip nose deformity patients. The study demonstrated a statistically significant difference between preoperative and postoperative evaluations among the studied patients regarding nostril height, alar base position, vertical lip length, nasal base inclination angle, and alar base width, with a high score of patient satisfaction.</p><p><strong>Level of evidence: </strong>Level II, therapeutic study.</p>","PeriodicalId":15462,"journal":{"name":"Journal of Craniofacial Surgery","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143728754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Posterior Pharyngeal Wall Augmentation: An Alternative Approach for Managing Nasal Regurgitation in Velopharyngeal Incompetence.","authors":"Mark H Moore, Sarut Chaisrisawadisuk, Christina Richards","doi":"10.1097/SCS.0000000000011290","DOIUrl":"https://doi.org/10.1097/SCS.0000000000011290","url":null,"abstract":"<p><p>This study examines the management of nasal regurgitation associated with velopharyngeal incompetence (VPI), a condition primarily recognized for its effects on speech. While significant surgical interventions are available for speech-related symptoms, nasal regurgitation often goes unnoticed. We assessed the effectiveness of posterior pharyngeal wall augmentation (PPWA) using costal cartilage as a treatment for patients experiencing nasal regurgitation due to VPI. A retrospective review was conducted at Cleft and Craniofacial South Australia over the past 5 years. Patients underwent simultaneous nasendoscopy and lateral videofluoroscopy evaluations. Our focus was on those suffering from nasal regurgitation who received PPWA. Among the 20 patients treated with PPWA, 8 specifically indicated nasal regurgitation. Five had regurgitation as their only symptom, while 3 had additional speech-related concerns. All patients noted a significant improvement in regurgitation symptoms postoperatively, along with an elevation of the posterior pharyngeal wall. Notably, no complications, such as graft exposure, were observed. The results indicate that PPWA is another effective surgical intervention for managing nasal regurgitation in VPI patients. This study promotes a multidisciplinary approach that combines treatment for both speech and nasal regurgitation, ultimately enhancing patient quality of life.</p>","PeriodicalId":15462,"journal":{"name":"Journal of Craniofacial Surgery","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143730105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Temporomandibular Joint Disc Replacement by Autogenous Composite Tissue Transplantation (Sandwich Method) in the Treatment of TMJOA With Perforation: A Preliminary Study.","authors":"Haoran Dong, Bimeng Jie, Shuo Chen, Jie Lei, Yang He","doi":"10.1097/SCS.0000000000011164","DOIUrl":"https://doi.org/10.1097/SCS.0000000000011164","url":null,"abstract":"<p><p>Temporomandibular joint (TMJ) disc replacement is a treatment option for severe temporomandibular joint osteoarthritis (TMJOA) with disc perforation, yet there is still a lack of an ideal disc substitute. This retrospective study evaluated the \"sandwich method,\" using a temporal myofascial flap (TMF) and auricular cartilage graft (ACG) as a composite tissue flap for disc replacement in patients treated at Peking University School of Stomatology between January 2021 and November 2023. Clinical assessments, including a maximum interincisal opening (MIO) and joint pain changes, and MRI and CBCT imaging of the TMJs were performed preoperatively and postoperatively (with a follow-up period of over 6 mo). A total of 5 patients were included in the study, with an average of 29.2 months of the course of disease. The average follow-up interval was 10.8 months. The mean preoperative and postoperative MIO was 29.9 and 38.0 mm. All 5 patients experienced relief from joint pain postoperatively, and condylar bone repair was observed (P<0.05). No complications were observed during the follow-up. This study introduces an effective method for treating TMJOA with disc perforation using TMF and ACG as a composite tissue flap (the sandwich method) for disc replacement, demonstrating favorable clinical outcomes.</p>","PeriodicalId":15462,"journal":{"name":"Journal of Craniofacial Surgery","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143730187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ear Replantation as Super-Microsurgery: Technical Tips.","authors":"ShinHyuk Kang, KyoBin Choo, JungSoo Yoon, SooA Lim, SuRak Eo","doi":"10.1097/SCS.0000000000011271","DOIUrl":"https://doi.org/10.1097/SCS.0000000000011271","url":null,"abstract":"<p><p>Compared with other techniques of ear reattachment, microvascular replantation produces a superior esthetic result. However, its rarity and very tiny vessel size make ear replantation a complex and difficult procedure for microsurgeons. With the development of microsurgical skills, it has been possible to restore even the partially amputated ear, as well as the totally avulsed ear. Currently, only a few successful results have been published as case reports and included in review articles. The authors present, for the first time in the literature, a small clinical series of ear replantations, together with super-microsurgical intraoperative video clips. The authors also share several technical tips for successful ear replantation, which might prove of help to microsurgeons.</p>","PeriodicalId":15462,"journal":{"name":"Journal of Craniofacial Surgery","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143729542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Three-Dimensional Morphometric Analysis of the Infraorbitale Foramen.","authors":"Esin Özşahin, Sema Polat, Zafer Altun, Mahmut Tunç, Ufuk Can Aksay, Pinar Göker","doi":"10.1097/SCS.0000000000011254","DOIUrl":"https://doi.org/10.1097/SCS.0000000000011254","url":null,"abstract":"<p><p>The infraorbital foramen (IOF) is a key reference point on the face, as the infraorbital nerve, which passes through it, is distributed across the face and provides sensation to important structures of midface region. The objective of this study is to conduct a morphometric analysis of the IOF in 3 dimensions. CBCT images of 92 individuals (50 females and 42 males) aged between 18 and 60 years were taken and transferred to the 3D Slicer program, and 3D images were obtained. Vertical and transverse diameter of the IOF and distance from IOF to inferior orbital margin, anterior nasal spine, and nasion were measured. IOF shapes (oval, round, triangular, and semilunar) were also determined in the study. While it was found that the transverse and vertical diameters of the IOF did not change statistically on the right according to gender (P>0.05), they changed statistically on the left (P<0.05). Furthermore, a statistically significant difference was observed in the distance measurements between the IOF and the anterior nasal spine, nasion, both on the right and left (P<0.05). In addition, a statistically significant difference was observed between the genders in the measured angle (P<0.05). The semilunar shape (41.3%) was more common on the right side, while oval (40.2%) and semilunar (39.1%) were seen more frequently and in close amounts on the left side. The 3-dimensional nature of our study distinguishes it from other studies in the literature. The authors suggest that these reference values will be helpful to clinicians for appropriate surgical and invasive procedure choices.</p>","PeriodicalId":15462,"journal":{"name":"Journal of Craniofacial Surgery","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143730216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nitrate Promotes the Survival of Diabetic Skin Flaps by Enhancing Autophagy Through the AMPK Signaling Pathway.","authors":"Mozi Li, Lin Zhu, Yifan Xu, Zhengxue Han","doi":"10.1097/SCS.0000000000011273","DOIUrl":"https://doi.org/10.1097/SCS.0000000000011273","url":null,"abstract":"<p><p>Random skin flap is commonly used for the repair of craniofacial defects. However, ischemic necrosis is frequently detected postoperatively, which severely affects patients' prognosis and quality of life, especially for those with diabetes. Although nitrate has been found to protect against the development of ischemic diseases, its effects on ischemic injury in diabetic skin flaps remains to be thoroughly explored. This study investigated the effects of nitrate on the survival of diabetic skin flaps and the associated mechanisms. The results showed that nitrate increased blood perfusion in diabetic skin flaps and decreased the area of ischemic necrosis. It also promoted angiogenesis, reduced apoptosis, and oxidative stress, while upregulating autophagy levels in the ischemic regions. These protective effects were reversed by the autophagy inhibitor, 3-MA, indicating that autophagy mediated the protective effects of nitrate on diabetic flaps. RNA-seq analysis revealed that nitrate activated the Adenosine 5'-monophosphate (AMP)-activated protein kinase (AMPK) signaling pathway in diabetic skin flaps. Inhibition of the AMPK phosphorylation by compound C reduced autophagy levels and reversed the protective effects. In conclusion, this study demonstrates that nitrate can promote the survival of diabetic skin flaps by improving angiogenesis, inhibiting apoptosis, and reducing oxidative stress. These beneficial effects are mediated by the enhancement of autophagy through the AMPK signaling pathway.</p>","PeriodicalId":15462,"journal":{"name":"Journal of Craniofacial Surgery","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143700535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Embryologic Basis of Craniofacial Structures.","authors":"Mutaz B Habal","doi":"10.1097/SCS.0000000000011229","DOIUrl":"https://doi.org/10.1097/SCS.0000000000011229","url":null,"abstract":"","PeriodicalId":15462,"journal":{"name":"Journal of Craniofacial Surgery","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143700473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}