{"title":"Triphasic Evolution of Spontaneous Calvarial Neo-Ossification After Decompressive Craniectomy: A 15-Year Serial Imaging Study.","authors":"Kaiyan Song, Min Wei, Hengzhu Zhang","doi":"10.1097/SCS.0000000000013456","DOIUrl":"https://doi.org/10.1097/SCS.0000000000013456","url":null,"abstract":"<p><p>Spontaneous cranial bone regeneration after decompressive craniectomy (DC) is rare in adults and has uniformly been described as a unidirectional, progressive process. The authors report the first case of a triphasic, nonlinear evolution-formation, resorption, and reactivation-of spontaneous calvarial neo-ossification in an adult. A 24-year-old man underwent bilateral DC for severe traumatic brain injury; the native dura was preserved almost intact on the left side, whereas the right side underwent extensive durotomy with expansile duraplasty. Serial computed tomography at 8 time points over 15 years revealed, on the left, patchy neo-ossification by day 107 that peaked around day 133, resorbed to a nadir at 9 months, reactivated at 23 months, and formed a continuous bony plate bridging the native bone margin by 15 years. The right side showed only 2 punctate bone islands at 15 years. Spontaneous neo-ossification in adults may be nonlinearly and reversibly regulated by the local biomechanical microenvironment, and the integrity of the native dura seems to be a key prerequisite for its initiation. These findings have implications for the timing of cranioplasty, choice of implant material, and duration of imaging follow-up.</p>","PeriodicalId":15462,"journal":{"name":"Journal of Craniofacial Surgery","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2026-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149110451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kyu-Ho Yi, Jong Keun Song, Han Earl Lee, Olena Sydorchuk
{"title":"Hypertonic Dextrose in Aesthetic Dermatology: Route-Dependent Evidence, Biological Rationale, and Research Priorities.","authors":"Kyu-Ho Yi, Jong Keun Song, Han Earl Lee, Olena Sydorchuk","doi":"10.1097/SCS.0000000000013471","DOIUrl":"https://doi.org/10.1097/SCS.0000000000013471","url":null,"abstract":"<p><strong>Objective: </strong>To critically evaluate whether local hypertonic dextrose has sufficient biological and clinical support to be considered an independent dermal biostimulant in aesthetic dermatology.</p><p><strong>Methods: </strong>PubMed/MEDLINE was searched from inception through June, 2026, with backward and forward citation tracking. Direct evidence included human aesthetic or dermatologic studies using local dextrose and translational studies examining dermal delivery or tissue response. Evidence was appraised by design, comparator, blinding, cointerventions, outcome validity, follow-up, and directness to a dextrose-specific effect.</p><p><strong>Results: </strong>Six human reports enrolled 125 participants in aggregate, and 2 translational studies examined pneumatic delivery. Favorable signals were reported for facial laxity, atrophic lesions, pores, fine wrinkles, and acne-scar volume. However, every human protocol included pneumatic pressure, microneedling, focused ultrasound, hyaluronic acid, or another active cointervention. A 5% versus 20% split-face study supports a concentration-dependent or osmolarity-dependent signal within pneumatic delivery, not glucose-specific neocollagenesis. Translational studies demonstrate device-induced tissue injury and penetration into fat and fascia. Reported adverse events were mainly transient; 2 cases of postinflammatory hyperpigmentation occurred in one 30-patient series.</p><p><strong>Conclusion: </strong>Hypertonic dextrose should be regarded as an investigational, route-dependent adjunct rather than an established stand-alone biostimulant. Controlled trials should isolate device, vehicle, osmolarity, and glucose-specific effects and include objective structural endpoints and long-term safety follow-up.</p>","PeriodicalId":15462,"journal":{"name":"Journal of Craniofacial Surgery","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2026-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149110448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ahad Daudi, Cameron J Leong, Hui Jie Gwen Farm, Brandon S Chai, Kevin Nickel
{"title":"A Comparison Between 2-Stage Versus 3-Stage Paramedian Forehead Flap Aesthetic Outcomes and Complications for Nasal Reconstruction: A Systematic Review and Meta-Analysis.","authors":"Ahad Daudi, Cameron J Leong, Hui Jie Gwen Farm, Brandon S Chai, Kevin Nickel","doi":"10.1097/SCS.0000000000013474","DOIUrl":"https://doi.org/10.1097/SCS.0000000000013474","url":null,"abstract":"<p><strong>Background: </strong>The paramedian forehead flap (PFF) remains the gold standard for complex nasal reconstruction; however, controversy persists regarding the optimal number of surgical stages. The 3-stage technique utilizes vascular delay to promote angiogenesis and allows for intermediate contour refinement, but inherently increases operative burden and health care resource utilization. This systematic review aimed to compare flap survival and aesthetic outcomes between 2-stage and 3-stage PFF reconstruction.</p><p><strong>Methods: </strong>A systematic search of MEDLINE, PubMed, EMBASE, and Web of Science (CRD420261296186) identified comparative studies reporting complications and aesthetic outcomes following 2-stage and 3-stage PFF repair. Results were pooled through pairwise meta-analysis and standardized mean differences (SMD) using Cohen's d model.</p><p><strong>Results: </strong>Seven studies comprising 428 patients were included in the final analysis: 221 patients underwent 2-stage PFF reconstruction and 207 patients underwent 3-stage reconstruction. Aesthetic outcomes were assessed in 3 studies (n=88) using a standardized mean difference model due to scale heterogeneity, demonstrating no significant difference between groups (SMD=-0.42, 95% CI: -2.40 to 1.56). Flap necrosis was reported in 6 studies (n=397), with no significant difference observed between 2-stage and 3-stage cohorts (OR=1.82, 95% CI: 0.78 to 4.28). Overall, neither flap survival nor aesthetic satisfaction differed significantly between the 2 reconstruction approaches.</p><p><strong>Conclusions: </strong>This review demonstrates comparable flap survival and aesthetic outcomes between 2-stage and 3-stage reconstructions. Future prospective studies utilizing standardized outcome measures are needed to clarify whether specific patient characteristics or defect complexities favor one technique.</p>","PeriodicalId":15462,"journal":{"name":"Journal of Craniofacial Surgery","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2026-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149110325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Francesco Arcuri, Francesco Laganà, Ferri Andrea, Ferrari Silvano, Lilloni Giovanni, Bernardo Bianchi
{"title":"Algorithm for the Treatment of Oronasal Communications: Introducing a Novel Classification.","authors":"Francesco Arcuri, Francesco Laganà, Ferri Andrea, Ferrari Silvano, Lilloni Giovanni, Bernardo Bianchi","doi":"10.1097/SCS.0000000000013472","DOIUrl":"https://doi.org/10.1097/SCS.0000000000013472","url":null,"abstract":"<p><strong>Introduction: </strong>Breach of the palate leading to a pathological communication between the oral cavity and the nose is known as oronasal communication/fistula (ONC). Various methods for the closure of communications have been reported in the literature, such as obturators, local flaps, and microvascular surgery. Due to the lack of a classification system for ONC, the purpose of this study was to trace an operative algorithm in a group of patients affected by ONC who underwent surgical reconstruction of the oronasal communication.</p><p><strong>Methods: </strong>A retrospective study was conducted for all patients affected by ONC who had undergone reconstruction between January 2016 and December 2021 at the University Hospital of Genoa and Parma. Our classification for ONC is based on the extent of the defect; clinical variations range from a defect <2 cm (type I) to a defect that includes both the hard and soft palate (type IV).</p><p><strong>Results: </strong>The final study population consisted of 19 patients (11 men and 8 women) with an average age at the time of surgery of 49.2 years (range: 18-78 y). Local flaps were the following: temporalis muscle flap (3 patients), palatal flap (3 patients), Bozola flap (3 patients), facial artery myomucosal flap (2 patients), temporalis fascia flap (1 patient), temporalis fascia flap plus Bichat flap (1 patient), temporalis fascia flap plus pharyngeal flap (1 patient), and Bichat flap (1 patient). Microvascular reconstructive procedures were adopted in 8 cases: forearm free flaps (6 patients), scapular tip plus serratus anterior free flap (1 patient), and serratus anterior free flap (1 patient). At the 1-year follow-up, all patients had no evidence of oronasal communications.</p><p><strong>Conclusion: </strong>Reconstructive options for ONC are still opinion-based rather than evidence-based. Our algorithm attempts to bridge this gap together with the latest opinions and trends in the treatment choice.</p>","PeriodicalId":15462,"journal":{"name":"Journal of Craniofacial Surgery","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2026-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149110469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Evaluation of Postoperative Facial Asymmetry Index Following Mandibular Reconstruction Using Free Fibular Flap With Condylar Involvement.","authors":"Parintosa Atmodiwirjo, Kristaninta Bangun, Rizka Khairiza, Vinca Nekezia","doi":"10.1097/SCS.0000000000013409","DOIUrl":"https://doi.org/10.1097/SCS.0000000000013409","url":null,"abstract":"<p><strong>Background: </strong>Loss of the temporomandibular joint (TMJ) following mandibulectomy disrupts maxillomandibular continuity and occlusion, potentially resulting in facial asymmetry with functional, structural, and aesthetic consequences. The free fibular flap remains the gold standard for mandibular reconstruction. However, the impact of condylar involvement on postoperative facial asymmetry remains poorly studied.</p><p><strong>Methods: </strong>A retrospective cohort study was conducted on patients undergoing free fibular flap mandibular reconstruction at Cipto Mangunkusumo Hospital (RSCM) between 2023 and 2025. Subjects were stratified based on the presence or absence of condylar involvement. Postoperative facial asymmetry was quantified using a 3D-derived asymmetry index (AI) based on predefined anatomic landmarks at the TMJ, mandibular angle, and mental region across the transverse (X), vertical (Y), and sagittal (Z) axes. Measurements were obtained using Autodesk Meshmixer and statistically analyzed to compare outcomes.</p><p><strong>Result: </strong>A total of 20 subjects were included, with comparable baseline demographics and mean evaluation periods of 23.20 and 23.80 months, respectively. At the mandibular angle, the condyle-involved group showed significantly greater asymmetry along the vertical (P=0.043) and sagittal axes (P=0.006). At the mental region, significant differences between the 2 groups were observed along the transverse (P=0.002) and sagittal axes (P=0.015). Notably, no significant asymmetry was observed at the TMJ region across any axis (P>0.05).</p><p><strong>Conclusion: </strong>Condylar involvement is a key determinant of postoperative mandibular asymmetry, particularly affecting vertical and sagittal alignment. These findings highlight the importance of incorporating condylar status into preoperative planning to optimize long-term facial symmetry outcomes.</p>","PeriodicalId":15462,"journal":{"name":"Journal of Craniofacial Surgery","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149110417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Non-Fixed Length Short-Incision Double Eyelid Blepharoplasty: A Retrospective Review of 60 Cases.","authors":"Shihan Shen, Jiapeng Yin","doi":"10.1097/SCS.0000000000012805","DOIUrl":"https://doi.org/10.1097/SCS.0000000000012805","url":null,"abstract":"<p><strong>Objective: </strong>To introduce a minimally invasive technique using a non-fixed length incision to create natural-looking, stable double eyelid folds.</p><p><strong>Methods: </strong>Preoperative assessment of eyelid characteristics was conducted, and a short incision of suitable length was made to remove a portion of the orbicularis oculi muscle. In some patients, partial removal of orbital septal fat (OSF) or orbital septum release may be performed concurrently as needed. The skin was then fixed to the pretarsal fascia and tarsus.</p><p><strong>Results: </strong>A total of 60 cases were reviewed in this study. Follow-up ranged from 6 to 55 months, during which no serious complications occurred. Except for 1 patient who experienced the disappearance of the double eyelid 50 months postoperatively, all others achieved satisfactory results. The overall satisfaction rate reached 98.3%.</p><p><strong>Conclusions: </strong>By conducting accurate preoperative assessments and employing incisions of appropriate length, this technique provides excellent clinical outcomes and deserves wider adoption.</p>","PeriodicalId":15462,"journal":{"name":"Journal of Craniofacial Surgery","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149110425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Craniofacial Injuries in International Football: From Return to Play to Prevention.","authors":"Luca Fiorillo, Vincenzo Ronsivalle, Marco Cicciù","doi":"10.1097/SCS.0000000000013480","DOIUrl":"https://doi.org/10.1097/SCS.0000000000013480","url":null,"abstract":"","PeriodicalId":15462,"journal":{"name":"Journal of Craniofacial Surgery","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149110482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"\"Multimodal Combined Treatment of a Ruptured Cerebellar Arteriovenous Malformation: A Report\".","authors":"Yichuan Qin, Hao Wang","doi":"10.1097/SCS.0000000000013411","DOIUrl":"https://doi.org/10.1097/SCS.0000000000013411","url":null,"abstract":"","PeriodicalId":15462,"journal":{"name":"Journal of Craniofacial Surgery","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149110328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Bone-Nerve Crosstalk: A 2016-2026 Bibliometric Analysis With Experimental Insights.","authors":"Dan Li, Zixuan Liu, Sirui Liu, Qingsong Jiang","doi":"10.1097/SCS.0000000000013286","DOIUrl":"https://doi.org/10.1097/SCS.0000000000013286","url":null,"abstract":"<p><strong>Background: </strong>This study aimed to systematically map the research landscape, collaboration patterns, and emerging trends in bone-nerve crosstalk from 2016 to 2026.</p><p><strong>Methods: </strong>A total of 4230 publications from the WoS were analyzed using CiteSpace and Bibliometrix. In vitro, Schwann cells were treated with BMDM conditioned medium, and neural marker expression was assessed. Ovariectomized mice were used to evaluate repair of Schwann cell markers in the sciatic nerve.</p><p><strong>Results: </strong>Annual publications rose steadily, peaking at 553 in 2025. China and the United States dominated productivity and citations. Early research focused on neural regeneration and stem cell transplantation, whereas recent burst keywords (3D bioprinting, hydrogels, extracellular vesicles, and tissue engineering) signaled a marked shift toward engineered regenerative platforms. Co-citation networks showed a foundation built on mesenchymal stem cell standards and peripheral nerve repair, and a transition toward biomaterial-enabled strategies. Experimentally, macrophage-conditioned medium upregulated neurogenic genes (NCAM and GAP43), increased TUBB3 protein expression, and induced an elongated Schwann cell morphology. In ovariectomized mice, both TUBB3 and MBP were elevated in the sciatic nerve, suggesting a repair-associated Schwann cell phenotype.</p><p><strong>Conclusions: </strong>Bone-nerve crosstalk research has evolved into an interdisciplinary, application-oriented field, increasingly driven by smart biomaterials and controlled delivery.</p>","PeriodicalId":15462,"journal":{"name":"Journal of Craniofacial Surgery","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149110475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Surgical Management of Malignant Eyelid Tumors: Reconstruction Outcomes and Location-Specific Thresholds for Preoperative Planning.","authors":"Anıl Ağaçkesen, Murat Oklar, Titap Yazıcıoğlu, Özlen Rodop Özgür, Ezgi Tanyeri Kılınç","doi":"10.1097/SCS.0000000000013473","DOIUrl":"https://doi.org/10.1097/SCS.0000000000013473","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate surgical outcomes of malignant eyelid tumor reconstruction and to develop location-specific tumor size thresholds and a preoperative nomogram for individualized reconstruction planning.</p><p><strong>Methods: </strong>A retrospective case series of 107 patients who underwent surgical excision and reconstruction for malignant eyelid tumors was conducted. Reconstruction techniques were classified as primary closure, local flap, free graft only, or combined reconstruction. Receiver operating characteristic (ROC) curve analysis was performed separately for upper and lower eyelid tumors to identify optimal tumor size thresholds. A logistic regression-based nomogram was developed and internally validated using 5-fold cross-validation.</p><p><strong>Results: </strong>Basal cell carcinoma was the most common diagnosis (79.4%), with a significant predilection for the lower eyelid compared with other tumor types (P=0.002). Tumor size differed significantly across reconstruction groups (P<0.001). Canthal involvement was present in 38.3% of patients and was associated with larger tumor size and more complex reconstruction (P<0.001), without adversely affecting complication or recurrence rates. ROC analysis demonstrated excellent discriminatory performance for upper eyelid tumors (AUC =0.953, 95% CI 0.870-1.000), with an optimal cutoff of ≥0.9 cm. In contrast, tumor size showed only fair performance for lower eyelid tumors (AUC =0.679, 95% CI 0.547-0.799). The nomogram demonstrated acceptable internal validity (AUC =0.754).</p><p><strong>Conclusion: </strong>Reconstruction complexity following malignant eyelid tumor excision is strongly influenced by tumor size and anatomical location. The predictive value of tumor size differed substantially between upper and lower eyelid tumors, highlighting the importance of individualized and anatomy-based surgical planning in periocular reconstruction.</p>","PeriodicalId":15462,"journal":{"name":"Journal of Craniofacial Surgery","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149110506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}