Journal of Craniofacial Surgery最新文献

{"title":"The Architect of Identity: The Life and Legacy of Dr. John M. Converse.","authors":"Ilana R Siegal, Sameep Kadakia, Mutaz B Habal","doi":"10.1097/SCS.0000000000012316","DOIUrl":"https://doi.org/10.1097/SCS.0000000000012316","url":null,"abstract":"","PeriodicalId":15462,"journal":{"name":"Journal of Craniofacial Surgery","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2026-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147838364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Single-Fraction Versus Fractionated Adjuvant Electron Beam Radiotherapy Following Excision of Auricular Keloids: A Retrospective Cohort Study.","authors":"Fang Tian, Fenghua Shi, Chunan Qu, Dongyue Li","doi":"10.1097/SCS.0000000000012855","DOIUrl":"https://doi.org/10.1097/SCS.0000000000012855","url":null,"abstract":"<p><p>Postoperative radiotherapy is effective for reducing recurrence of auricular keloids, yet the optimal dose fractionation remains debated. This retrospective cohort study compared single-fraction 10 Gy versus fractionated 10 Gy (2×5 Gy) electron beam radiotherapy following keloid excision. Seventy-seven patients were enrolled, with 37 receiving a single 10 Gy fraction (group A) and 40 receiving 5 Gy×2 fractions (group B). All patients underwent complete surgical excision and initiated radiotherapy within 24 hours postoperatively. The primary endpoint was local recurrence; secondary endpoints included scar aesthetic quality assessed using the Patient and Observer Scar Assessment Scale (POSAS 2.0) and radiotherapy-related complications. With a median follow-up of 19.0 months in both groups, the recurrence rate was 2.7% in group A and 7.5% in group B (P=0.616). The total observer POSAS score was significantly lower in group A (14.3±3.7 versus 16.5±4.3, P=0.019), indicating superior objective scar quality, while patient-reported scores showed no significant difference. Both regimens were well-tolerated, with no severe adverse events and comparable rates of acute dermatitis, pigmentary changes, and telangiectasia. In conclusion, single-fraction 10 Gy electron beam radiotherapy achieves comparable local control to fractionated 10 Gy and yields superior objective aesthetic outcomes. Combined with its convenience and health economic advantages, single-fraction 10 Gy represents a safe and preferred clinical option for auricular keloids.</p>","PeriodicalId":15462,"journal":{"name":"Journal of Craniofacial Surgery","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2026-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147838518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Esthetic Unit-Based Surgical Management of Large Facial Plexiform Neurofibromas.","authors":"Tuan-Anh Hoang, Diep L Le, Thang D Nguyen, Ngoc D Nguyen, Van T Phan, Son T Tran","doi":"10.1097/SCS.0000000000012822","DOIUrl":"https://doi.org/10.1097/SCS.0000000000012822","url":null,"abstract":"<p><p>Large facial plexiform neurofibromas in patients with neurofibromatosis type 1 (NF1) often cause extensive soft-tissue hypertrophy, facial asymmetry, and functional impairment, resulting in significant aesthetic and psychosocial morbidity. Complete excision is often unfeasible because of infiltrative growth, indistinct margins, and high tumor vascularity. Accordingly, staged resection combined with tailored reconstruction represents a pragmatic surgical strategy. The authors retrospectively evaluated outcomes of an aesthetic unit-based, staged surgical approach in patients with large facial plexiform neurofibromas treated at Hanoi Medical University Hospital and 108 Military Central Hospital between 2018 and 2024. Nineteen patients (12 females and 7 males; mean age, 28 years) were included. Tumors most commonly involve the cheek, temporal, and periorbital regions. Near-total excision (>90%) was achieved in 4 patients, subtotal excision (50%-90%) in 12 patients, and planned staged partial excision (<50%) in 3 patients, with a mean of 4 procedures per patient. Immediate reconstruction was performed using 1 free flap and 18 local and/or regional flaps selected according to defect location and vascular reliability. All flaps survived. Minor complications occurred in 16.7% of patients and were managed conservatively. Objective aesthetic assessment demonstrated significant improvement in facial symmetry, with the mean Facial Symmetry Index decreasing from 1.35±0.18 preoperatively to 1.12±0.10 postoperatively (P<0.001). Patient-reported outcomes measured using the Global Aesthetic Improvement Scale indicated high satisfaction (mean score: 4.2/5). An aesthetic unit-based approach incorporating staged excision and individualized reconstruction yields reliable functional recovery and satisfactory aesthetic outcomes in patients with large facial plexiform neurofibromas.</p>","PeriodicalId":15462,"journal":{"name":"Journal of Craniofacial Surgery","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2026-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147838586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reconstruction of Surgical Defects From Early Carcinoma of Tongue Supported by Cross-Linked Hyaluronic Acid.","authors":"Roberta Iaria, Paolo Vescovi, Carmen Mortellaro, Alberta Greco Lucchina, Anton Friedmann, Ilaria Giovannacci","doi":"10.1097/SCS.0000000000012815","DOIUrl":"https://doi.org/10.1097/SCS.0000000000012815","url":null,"abstract":"<p><strong>Background: </strong>Although treatment strategies for oral cancer of the tongue are determined based on the stage of the malignant lesion, surgical resection remains the cornerstone of therapy. Depending on the extent of the tumor, tissue resection can result in aesthetic and functional alterations of varying severity, with a significant impact on the patient's quality of life.</p><p><strong>Methods: </strong>The following paper describes an innovative surgical technique performed under local anesthesia in an outpatient setting that combines the application of a cross-linked hyaluronic acid gel with a biocompatible membrane for the reconstruction of surgical defects after the excision of early-stage tongue carcinoma (T1-2, N0, DOI <5 mm). Five clinical cases of patients undergoing partial glossectomy with Neodymium-Doped Yttrium Aluminum Garnet (Nd:YAG) laser surgery are reported. Postoperative outcomes were evaluated at 1 week, 3 weeks, 2 months, and 1 year, focusing on wound healing, patient-reported symptoms, and functional recovery.</p><p><strong>Results: </strong>The evaluations showed that the proposed surgical technique was well tolerated by patients and resulted in favorable healing within 2 months. Furthermore, no complications or disease recurrence were observed.</p><p><strong>Conclusions: </strong>These results indicate that the proposed approach, performed under local anesthesia, may represent a valid reconstructive surgical option for early-stage tongue cancer, as it is associated with operative advantages such as the absence of a donor site and postoperative complications related to harvesting.</p>","PeriodicalId":15462,"journal":{"name":"Journal of Craniofacial Surgery","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2026-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147838317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Material Science and Bioengineering Principles of Injectable Facial Fillers: Rheological Properties and Structural Design-Part A.","authors":"Brett P Weiss, Hana Shah, Nicholas J Iglesias, Sara E Munkwitz, Camilla Christian Gomes Moura, Jonathan P Yasmeh, Vasudev Vivekanand Nayak, Isabela Fleischfresser, Seth R Thaller, Paulo G Coelho","doi":"10.1097/SCS.0000000000012830","DOIUrl":"https://doi.org/10.1097/SCS.0000000000012830","url":null,"abstract":"<p><p>Injectable dermal fillers represent a rapidly evolving class of soft-tissue biomaterials whose clinical behavior is determined by their underlying material properties. Despite widespread use in aesthetic medicine, the relationships between structure and behavior that dictate filler performance remain incompletely synthesized across material classes. This review examines the material science foundations of modern dermal fillers, spanning hyaluronic acid formulations, collagen-based materials, and biostimulatory systems, including calcium hydroxylapatite, poly-L-lactic acid, and polycaprolactone. Emphasis is placed on the material parameters that govern filler behavior in vivo, such as polymer chemistry, crosslinking methodology, particulate microstructure, and degradation kinetics. These factors collectively determine key rheological characteristics such as storage modulus (G'), loss modulus (G″), cohesivity, and injectability. In turn, these influence material stability, tissue integration, and resistance to mechanical deformation within dynamic facial environments. Recent advances in formulation strategies, including multiphasic fillers, microspheres, and hybrid systems, illustrate how modification of microstructure can be leveraged to improve durability, biocompatibility, and tissue remodeling potential. This review establishes a mechanistic framework linking filler composition to rheological performance and degradation behavior. As the first part of a 2-part review, the focus here is on the material science and bioengineering principles that inform filler behavior in order to provide the scientific foundation for the clinical decision-making framework explored in Part B.</p>","PeriodicalId":15462,"journal":{"name":"Journal of Craniofacial Surgery","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2026-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147838608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Polynucleotide-Hyaluronic Acid Gel as an Adjunct to Tooth Extraction in Patients at Risk of MRONJ: A Randomized Split-Mouth Clinical Trial.","authors":"Vincenzo Ronsivalle, Umberto Cammarata, Rosario Perrotta, Roberta Giudice, Marco Cicciù","doi":"10.1097/SCS.0000000000012842","DOIUrl":"https://doi.org/10.1097/SCS.0000000000012842","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate whether adjunctive intrasocket application of a polynucleotide-hyaluronic acid gel improves early post-extraction soft-tissue healing and postoperative pain in patients exposed to medications associated with medication-related osteonecrosis of the jaw.</p><p><strong>Materials and methods: </strong>In this single-center randomized split-mouth clinical study, adults requiring bilateral simple tooth extractions in the same arch and opposite hemi-arches underwent 2 procedures in separate sessions spaced 4 weeks apart. After extraction and socket debridement, the test site received 5 mL of polynucleotide-hyaluronic acid gel (Regenfast®) before primary closure, whereas the control site received standard management without adjunctive biomaterial. Wound healing was assessed using the inflammatory proliferative remodeling (IPR) wound-healing scale. The primary outcome was the total IPR score at 6 weeks. Secondary outcomes were IPR subscale scores at 3 to 5 days, 14 days, and 6 weeks, and postoperative pain measured with the Numerical Rating Scale (NRS). Paired comparisons were performed with appropriate within-patient tests.</p><p><strong>Results: </strong>Thirty-two patients (13 men, 19 women) completed follow-up without adverse events. No significant differences were found between test and control sites at 3 to 5 days (P=0.521), at 6 weeks (P=0.841), or for total IPR score at 6 weeks (P=0.318). A statistically significant difference favoring the test sites was observed at 14 days (P<0.05). Postoperative pain did not differ between sites (P=0.873).</p><p><strong>Conclusions: </strong>Adjunctive polynucleotide-hyaluronic acid gel was associated with a phase-specific improvement in soft-tissue healing at 14 days, without significant differences in overall 6-week healing or pain.</p>","PeriodicalId":15462,"journal":{"name":"Journal of Craniofacial Surgery","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2026-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147838121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of Demographic Features and Risk Factors in Patients With Ocular Trauma.","authors":"Yunus Fidan, Ömer Özer, Levent Doğan, Zeki Baysal","doi":"10.1097/SCS.0000000000012901","DOIUrl":"https://doi.org/10.1097/SCS.0000000000012901","url":null,"abstract":"<p><strong>Background: </strong>The aim of this study is to determine the demographic characteristics of patients with closed or open globe injuries at a tertiary referral center and to analyze the risk factors associated with the occurrence of ocular trauma.</p><p><strong>Methods: </strong>Data on age, gender, education level, affected eye, type of trauma (closed or open globe), and location (workplace, home, traffic), and any accompanying systemic injuries, ocular trauma score, and visual acuity were recorded for all patients.</p><p><strong>Results: </strong>A total of 1,638,568 adult and pediatric emergency department visits were analyzed in the study. Of these visits, 4546 involved patients with ocular trauma. Among patients with ocular trauma, 589 were children, and 3957 were adults. Work-related injuries were reported in 869 of the patients in our study. Of the patients with work-related injuries, 804 were male. The risk of a work-related injury was found to be 6.56 times higher in males compared with females. Only 15 of these patients were wearing protective eyewear and/or a welding shield at the time of the incident. All patients with sports injuries and bullet/gunshot wounds were male. The age distribution of patients with ocular trauma due to falls peaked in 2 age groups: young males aged 20 to 30 and adults aged 70 and older.</p><p><strong>Conclusion: </strong>In conclusion, ocular trauma is more common among males and is frequently associated with workplace accidents. Closed globe injuries are the predominant type, and high-energy trauma, such as bullet wounds, is associated with poorer visual acuity. Furthermore, the fact that falls and injuries from sharp/piercing tools are among the most common causes, combined with the very low rate of protective equipment use, indicates that these injuries are largely preventable. Therefore, enhancing workplace safety measures, promoting the widespread use of protective equipment, and developing educational programs to raise public awareness will play a critical role in reducing the frequency and severity of ocular trauma.</p>","PeriodicalId":15462,"journal":{"name":"Journal of Craniofacial Surgery","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2026-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147838459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vertigo Presentations to the Emergency Departments in Mersin, Türkiye: Demographics, Etiologic and Clinical Patterns.","authors":"Fatma Örs, Mesut Yeşilova, Muhammet Ali Erinmez","doi":"10.1097/SCS.0000000000012852","DOIUrl":"https://doi.org/10.1097/SCS.0000000000012852","url":null,"abstract":"<p><strong>Objective: </strong>To describe the demographic characteristics, symptom profiles, comorbidities, investigation patterns, and treatments of patients presenting with vertigo at emergency departments in Mersin, Türkiye, and to identify predictors of advanced imaging (CT and/or MRI).</p><p><strong>Methods: </strong>A retrospective review of 4656 de-identified emergency department cases admitted between 2022 and 2025 was performed. Variables included age, sex, comorbidities (diabetes, hypertension, infection), symptoms (imbalance, tinnitus, nausea), laboratory risk factors (high hematocrit, high cholesterol, high lipid profile), diagnostic workup (audiometry, CT, MRI), and treatments (medical therapy, maneuvers, hyperbaric oxygen). Multivariable logistic regression was used to evaluate predictors of advanced imaging.</p><p><strong>Results: </strong>The mean age was 53.0 ± 19.3 years (median 54, IQR 37-70); 2742 (58.9%) were female. Hypertension was recorded in 1303 (28.0%) and diabetes in 976 (21.0%). Advanced imaging (CT/MRI) was documented in 1314 (28.2%). In adjusted analysis, age and cardiometabolic risk factors were associated with increased odds of advanced imaging.</p><p><strong>Conclusion: </strong>ED vertigo cases in Mersin mainly affect middle-aged to older adults and often occur alongside cardiometabolic comorbidities. The use of advanced imaging correlates with age and the number of risk factors, supporting structured ED risk assessment.</p>","PeriodicalId":15462,"journal":{"name":"Journal of Craniofacial Surgery","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2026-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147838350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Economic Valuation and Disability Averted After Cleft Lip and/or Palate Repair in Botswana From 2018 to 2022.","authors":"Isabel A Ryan, Allison C Hu, Mattia A Mahmoud, Dominic J Romeo, Connor S Wagner, Philip D Tolley, Nicholas A Han, Zina Khona, Warona S Motlhwa, Obakeng Vincent Lekaba, Katso Salo, Ludo Masole, Merrian J Brooks, Jesse A Taylor, Uamunovandu Tjinjeka, Jordan W Swanson","doi":"10.1097/SCS.0000000000012787","DOIUrl":"https://doi.org/10.1097/SCS.0000000000012787","url":null,"abstract":"<p><strong>Background: </strong>Little is known about access to surgical care for patients with cleft lip and/or palate (CL/P) in Botswana, nor have the effects on both the patient and the societal level been quantified. This study aims to assess the impact of CL/P repair on patient disability and economic productivity over a 5-year period in Botswana.</p><p><strong>Methods: </strong>A retrospective review of on-site surgical logbooks was used to identify all primary CL/P procedures from 2018 to 2022 across 6 geographically diverse hospitals throughout Botswana. Demographic and procedure-level data were collected. Disability-adjusted life years (DALYs) were calculated for each patient using Global Burden of Disease (GBD) reported disability weights and Botswana-specific life expectancy by sex, as well as estimates of residual disability. Averted DALYs and Botswana's GNI per capita (Atlas and Purchasing Power Parity) were used to determine the economic gains achieved over this 5-year period.</p><p><strong>Results: </strong>Eighty primary CL/P procedures were performed from 2018 to 2022, of which 51.3% (n=41) were cleft lip repair and 48.7% (n=39) were cleft palate repair. The average age at surgery was 4±5 years. Average averted DALYs ranged from 231.5 to 326.1 when utilizing the GBD and Effectiveness Factor Burden of Disease Calculation, respectively. This translated into an average of $24,130.14 to $76,987.60 economic gains per procedure. When considering the total economic impact of these procedures, this translated into $1,930,411.34 to $6,159,007.69 in economic productivity based on Atlas and Purchasing Power Parity calculations.</p><p><strong>Conclusions: </strong>This study highlights the importance of CL/P care in Botswana and the potential impact it has on patients and the large-scale economy. Despite the low numbers of CL/P repairs performed over this 5-year period, there was a meaningful reduction in disability and a resultant increase in the realization of economic gains, showing the need for continued investment in surgical capacity.</p>","PeriodicalId":15462,"journal":{"name":"Journal of Craniofacial Surgery","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2026-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147838583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Could Autism Spectrum Disorder Be Associated With Craniosynostosis?","authors":"Megan E H Still, Amelia Alberts, Prianca Nagda, Chance Fleeting, Isaac Smith, Kyle Ockerman, Sabrina Han, Lance Governale, Jessica Ching","doi":"10.1097/SCS.0000000000012817","DOIUrl":"https://doi.org/10.1097/SCS.0000000000012817","url":null,"abstract":"<p><strong>Introduction: </strong>Craniosynostosis is a common pediatric condition that results in variable symptoms that range from asymptomatic cosmetic deformities to severe signs of intracranial hypertension. Little is understood about the relationship between craniosynostosis and neurocognitive and neurodevelopmental symptoms, including autism spectrum disorder (ASD).</p><p><strong>Objective: </strong>The purpose of this study is to compare skull vault measurements between patients with ASD and craniosynostosis to determine if those with ASD have abnormal findings related to synostotic changes.</p><p><strong>Methods: </strong>The authors performed a retrospective chart review of pediatric patients with CT scans of the head to compare several cranial vault measurements between children with craniosynostosis, those with ASD, and those with neither diagnosis.</p><p><strong>Results: </strong>One hundred ninety-eight patients' CT scans were reviewed. Of those with sagittal craniosynostosis, significant differences were found in cephalic index, interparietal distance, intercoronal distance, and metopic severity index between controls and those with craniosynostosis, but not between controls and those with ASD, nor between those with craniosynostosis with or without ASD. Of those with metopic craniosynostosis, significant differences were found in metopic angle, interparietal distance, intercoronal distance, and metopic severity index between controls and those with craniosynostosis, but not between controls and those with ASD, nor between those with craniosynostosis with or without ASD. There were no significant measurement differences between those with craniosynostosis alone and those with craniosynostosis and ASD diagnosis in either type of craniosynostosis.</p><p><strong>Conclusions: </strong>No significant differences were found in cranial vault measurements of patients with ASD versus controls. Among patients with craniosynostosis, those who also had ASD did not have significantly different measurements, although the population was small. It is likely that the 2 diagnoses are incidental rather than causal.</p>","PeriodicalId":15462,"journal":{"name":"Journal of Craniofacial Surgery","volume":" ","pages":""},"PeriodicalIF":1.0,"publicationDate":"2026-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147838484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}