Journal of Current Ophthalmology最新文献

{"title":"Cross-Sectional Study of Differences between Intraocular Pressure Measurements using Goldmann, iCare, and Air-Puff Tonometers and their Correlation with Central Corneal Thickness.","authors":"Sameh Saad Mandour, Ahmed Elframawy, Mohammad Moataz Murad, Sara Abd Elmegeed Nage","doi":"10.4103/joco.joco_180_23","DOIUrl":"https://doi.org/10.4103/joco.joco_180_23","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the agreement between the Goldmann tonometer (GAT), the air-puff tonometer, and the iCare tonometer in intraocular pressure (IOP) evaluation as well as their association with central corneal thickness (CCT) in normal participants, glaucoma patients, and patients following refractive surgery.</p><p><strong>Methods: </strong>This is a cross-sectional study conducted on 204 eyes from 102 patients. The study consisted of three equal groups: group I (control group, <i>n</i> = 34), group II (glaucoma patients on medication, <i>n</i> = 34), and group III (refractive surgery patients, <i>n</i> = 34). All patients were subjected to examination (complete ocular examination, refraction, and IOP measurement).</p><p><strong>Results: </strong>A total of 102 participants were included in the study with both genders distributed equally. The mean ± standard deviation age was 44.12 ± 12.8 years in the control group while it was 46.29 ± 13.24 years in the glaucoma group and 40.68 ± 15.86 years in the refractive surgery group. Overall, there was a high correlation between the three methods. The mean IOP measured by GAT was 14.03 ± 3.43. The mean IOP measured by iCare was 15.16 ± 3.46. The mean IOP measured by air-puff was 16.66 ± 3.6. The iCare showed the most significant agreement with the GAT (intraclass correlation coefficient [ICC] 0.985, <i>P</i> > 0.05) and the mean difference in IOP between GAT and iCare was 1.1 (95% limits of agreement, -0.62-+2.85 mmHg). The mean difference in IOP between iCare and air-puff was 1.5 and it was 2.6 between GAT and air-puff. There were no significant differences in IOP measurements between GAT and iCare tonometer or between iCare tonometer and air-puff in all groups (<i>P</i> > 0.05). However, there were significant differences in IOP measurements between GAT and air-puff in all groups (<i>P</i> < 0.001). The ICC between all studied methods was strong (ICC > 0.92 for all). Regarding CCT, the mean CCT was 517.14 ± 29.82 μm. There were significant positive correlations between increasing CCT and increasing IOP by GAT, iCare, and air-puff tonometer among the three groups (<i>P</i> < 0.001).</p><p><strong>Conclusions: </strong>In conclusion, the iCare tonometer, specifically the iCare PRO RT model, is a reliable and efficient alternative instrument for assessing IOP. The IOP values obtained with the iCare PRO RT were found to be consistent with those obtained using the air-puff and GAT.</p>","PeriodicalId":15423,"journal":{"name":"Journal of Current Ophthalmology","volume":"35 4","pages":"326-331"},"PeriodicalIF":1.2,"publicationDate":"2024-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11392305/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142288291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hereditary Multiple Exostoses with Rare Ocular Finding: A Case Report.","authors":"Shashi Tanwar, Nishtha Saini, Krutika Boriwal, Prashant Sharma","doi":"10.4103/joco.joco_128_23","DOIUrl":"https://doi.org/10.4103/joco.joco_128_23","url":null,"abstract":"<p><strong>Purpose: </strong>To study rare ocular findings in a rare case of hereditary multiple exostoses (HME) and to study HME in one family.</p><p><strong>Methods: </strong>HME is an autosomal dominant genetic disease characterized by the presence of multiple exostoses (osteochondromas). It is caused by mutations in two genes: exostosin-1 (EXT1) and exostosin-2 (EXT2). We report HME in a family over three generations. The index case was a 14-year-old female who presented with an ocular mass and multiple hard nodules in the upper and lower limbs. Family history revealed similar multiple nodules in the younger brother, father, and grandfather. Hence, the paternal family history for HME is positive. All the family members were examined. Family members who were diagnosed with HME had a series of radiology tests completed. Furthermore, the family members with HME were also seen by an orthopedic surgeon.</p><p><strong>Results: </strong>Family history and physical examination revealed multiple exostoses in the younger brother, father, and grandfather. They were all diagnosed with HME. The index case also had an ocular surface mass with scleral ectasia in the right eye.</p><p><strong>Conclusion: </strong>HME is a rare, genetic disorder. Cases of HME with ocular findings are rare. This patient has a paternal family history of HME and presents with an ocular surface mass.</p>","PeriodicalId":15423,"journal":{"name":"Journal of Current Ophthalmology","volume":"35 4","pages":"411-414"},"PeriodicalIF":1.2,"publicationDate":"2024-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11392300/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142288273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Low Ocular Perfusion Pressure Values at Rest and during Resistance Exercise in Offspring of Glaucoma Patients.","authors":"Diana de Medeiros Andrade, Jordane Benedito Vargas Oliveira, Marta Halfeld Ferrari Alves Lacordia, Mateus Camaroti Laterza, Daniel Godoy Martinez","doi":"10.4103/joco.joco_207_23","DOIUrl":"https://doi.org/10.4103/joco.joco_207_23","url":null,"abstract":"<p><strong>Purpose: </strong>To compare the ocular perfusion pressure (OPP) response during physical exercise in individuals with and without a family history (FH+, FH-) of glaucoma.</p><p><strong>Methods: </strong>Thirty-four subjects, divided into FH+ and FH- groups, realized 3 min at rest, 3 min of isometric handgrip exercise at 30% of maximal voluntary contraction, followed by 3 min of recovery. Blood pressure (Dixtal^® automatic device) and intraocular pressure (Goldmann applanation tonometer) were measured during rest, exercise, and recovery. The mean OPP (mOPP) was calculated.</p><p><strong>Results: </strong>In the FH+ group (17 subjects), baseline mOPP values were significantly lower than in the FH- group (17 subjects) (right eye: <i>P</i> < 0.001, left eye: <i>P</i> < 0.001, respectively). During exercise, both the FH+ and FH- groups showed a similar increase in mOPP in both eyes (right eye: FH+: 38 ± 4 mmHg vs. 51 ± 7 mmHg, FH-: 48 ± 5 mmHg vs. 57 ± 9 mmHg, <i>P</i> < 0.001; left eye: FH+: 39 ± 3 mmHg vs. 51 ± 7 mmHg; FH-: 46 ± 5 mmHg vs. 58 ± 8 mmHg, <i>P</i> < 0.001, respectively). However, the FH+ group maintained significantly lower mOPP values compared to the FH- group in the right and left eyes (group effect: <i>P</i> = 0.002, <i>P</i> = 0.002, respectively). The percentage of increase in mOPP in the FH+ group was greater compared to the FH- group during exercise (right eye: 34.1% ± 15.9% vs. 22.1% ± 13.2%, respectively; <i>P</i> = 0.025; left eye: 33.2% ± 17.7% vs. 22.4% ± 13.7%, respectively, <i>P</i> = 0.056).</p><p><strong>Conclusions: </strong>mOPP increased during physical exercise in both groups, but the FH+ group had lower absolute values. In addition, the FH+ group appears to demonstrate a higher percentage increase in mOPP compared to the FH- group.</p>","PeriodicalId":15423,"journal":{"name":"Journal of Current Ophthalmology","volume":"35 4","pages":"320-325"},"PeriodicalIF":1.2,"publicationDate":"2024-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11392303/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142288276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of Corneal Biomechanical Properties using Scheimpflug Camera-Based Imaging in Night Shift Medical Staff.","authors":"Keyvan Shirzadi, Ali Makateb, Hassan Asadigandomani, Maziyar Irannejad","doi":"10.4103/joco.joco_196_23","DOIUrl":"https://doi.org/10.4103/joco.joco_196_23","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the effect of night shifts on the biomechanical properties of the cornea using Scheimpflug camera-based imaging (Corvis and Pentacam).</p><p><strong>Methods: </strong>Thirty-four participants from the medical staff who had at least six night shifts per month as a case group and fifty-two participants as a control group participated in the study. The biomechanical characteristics of the cornea using the Corvis device and the topographical characteristics of the cornea using the Pentacam device were investigated in the participants.</p><p><strong>Results: </strong>The main indices of corneal biomechanics including Corvis Biomechanical Index (0.17 ± 0.18 vs. 0.15 ± 0.14; <i>P</i> = 0.66 [adjusted] and 0.66 [unadjusted]) and Tomographic and Biomechanical Index (0.16 ± 0.19 vs. 0.14 ± 0.19; <i>P</i> = 0.78 [adjusted] and 0.63 [unadjusted]) were not significantly different between case and control groups.</p><p><strong>Conclusion: </strong>Our study showed that night shifts do not independently affect corneal biomechanical indices.</p>","PeriodicalId":15423,"journal":{"name":"Journal of Current Ophthalmology","volume":"35 4","pages":"345-349"},"PeriodicalIF":1.2,"publicationDate":"2024-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11392290/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142288285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electrophysiological and Visual Parameter Changes in Retinitis Pigmentosa Patients undergoing Autologous Platelet-Rich Plasma Therapy: A Randomized Control Trial.","authors":"Perwez Khan, Lubna Khan, Kumari Kanchan Kiran","doi":"10.4103/joco.joco_216_22","DOIUrl":"https://doi.org/10.4103/joco.joco_216_22","url":null,"abstract":"<p><strong>Purpose: </strong>To assess the efficacy of autologous platelet-rich plasma (PRP) injections in suprachoroidal space and subtenon space in cases of retinitis pigmentosa, which is a genetic disease, leading to gradual loss of vision. Till date, no treatment is available.</p><p><strong>Methods: </strong>Seventy-eight eyes of 39 patients of retinitis pigmentosa having visual acuity ranging from reading of Early Treatment Diabetic Retinopathy Study (ETDRS) chart from 1 m onward to patients who were not able to read the ETDRS chart but whose visual acuity ranged from finger count close to face to <1 m were included in the study. The left and right eyes of each patient were randomized as the intervention eye and control eye. 0.2 mL of autologous PRP was injected in suprachoroidal space and 0.5 mL of PRP was injected in subtenon space of the intervention eye taking aseptic precautions. Injections were repeated at 15-day intervals up to 3 injections.</p><p><strong>Results: </strong>Majority of patients were in the age group of 18-30 years (20 cases) followed by 31-45 years (13 cases) and more than 45 years (6 cases). Intervention eyes showed a statistically significant improvement in visual acuity and multifocal electroretinography (mfERG). Improvement was noted in amplitude density latency and in ring ratio of mfERG. There was a significant improvement in best-corrected visual acuity (BCVA). However, no improvement in mfERG or BCVA was observed in the control group.</p><p><strong>Conclusions: </strong>Gene therapy may be the ultimate cure for retinitis pigmentosa, but it is unaffordable for many patients due to its high cost. PRP may be recognized as a modality to improve vision and stop further deterioration, especially in cases where functional vision is preserved. Negligible treatment costs and affordability will give power to economically disadvantaged patients.</p>","PeriodicalId":15423,"journal":{"name":"Journal of Current Ophthalmology","volume":"35 3","pages":"267-275"},"PeriodicalIF":1.5,"publicationDate":"2024-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11047807/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140864901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multiple Bilateral Retinal Pigment Epithelial Detachments in a Patient with Systemic Lupus Erythematosus: A Case Report.","authors":"Renata Diniz Lemos, Ahmad Mohamad Ali Hamade, Leangelo Nicholas Hall, Maurício Abujamra Nascimento","doi":"10.4103/joco.joco_267_22","DOIUrl":"https://doi.org/10.4103/joco.joco_267_22","url":null,"abstract":"<p><strong>Purpose: </strong>To report a case of multiple bilateral retinal pigment epithelial detachments (PEDs) in a woman with systemic lupus erythematosus (SLE).</p><p><strong>Methods: </strong>Case Report.</p><p><strong>Results: </strong>A 28-year-old female with mild blurred bilateral vision in both eyes (OU) without pain or any other symptom was admitted to the hospital due to worsening renal function and uncontrolled high blood pressure (HBP). Best-corrected visual acuity (BCVA) was 20/30 and 20/40, right and left eyes, respectively. She had SLE, glucose-6-phosphate dehydrogenase deficiency, and immune thrombocytopenic purpura. BP was over 150/90 mmHg for more than 1.5 years, and she used corticosteroids at varying doses for more than 4 years. During hospitalization, she was taking prednisone 60 mg daily as Class IV lupus nephritis was diagnosed. On fundoscopy, she had a lacy retinal pattern, remarkably on the macula in OU. Spectral-domain optical coherence tomography revealed multiple bilateral serous PEDs and pachychoroid. Angiofluoresceinography displayed multiple pooling hyperfluorescence areas. Six months afterward, while she was on prednisolone 10 mg daily, and antihypertensive medications, BCVA was improved to 20/25 OU. Nevertheless, she had no retinal or choroidal changes. Her findings could be related to SLE choroidopathy, central serous chorioretinopathy-like disease, and/or hypertensive choroidopathy.</p><p><strong>Conclusions: </strong>Ocular involvement affects nearly one-third of SLE patients. The findings are variable and can include nearly any part of the eyeball. Multiple bilateral PEDs have been described in the literature; however, in this case, it is probably multifactorial and not only related to SLE.</p>","PeriodicalId":15423,"journal":{"name":"Journal of Current Ophthalmology","volume":"35 3","pages":"287-290"},"PeriodicalIF":1.5,"publicationDate":"2024-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11047803/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140855359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hypotony and Anterior Uveitis following Dual Therapy with Nivolumab and Ipilimumab for Metastatic Melanoma: A Case Report.","authors":"Nikhil S Patil, David Dudok, Sarit Khimdas","doi":"10.4103/joco.joco_21_23","DOIUrl":"https://doi.org/10.4103/joco.joco_21_23","url":null,"abstract":"<p><strong>Purpose: </strong>To describe a rare case of hypotony and anterior uveitis following dual therapy with nivolumab and ipilimumab for metastatic melanoma.</p><p><strong>Methods: </strong>Case report.</p><p><strong>Results: </strong>Here, we present the case of a 64-year-old man taking nivolumab and ipilimumab dual therapy for BRAF+ (v-raf murine sarcoma viral oncogene homolog B1) metastatic melanoma. After treatment for 3 months, he presented to the ophthalmology clinic with bilateral intraocular pressures of 1 mmHg, bilateral keratic precipitates, cataracts, posterior synechiae, and anterior chamber inflammation. He improved with topical medications and the cessation of immunotherapy.</p><p><strong>Conclusions: </strong>Immunotherapies are a novel class of chemotherapy that has increased in prevalence for the treatment of numerous malignancies. There are many rare complications from these medications that are sparsely reported. Knowledge of ocular hypotony as a potential consequence of nivolumab and ipilimumab is important, particularly as it may arise months after treatment initiation and necessitate immunotherapy cessation.</p>","PeriodicalId":15423,"journal":{"name":"Journal of Current Ophthalmology","volume":"35 3","pages":"294-296"},"PeriodicalIF":1.5,"publicationDate":"2024-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11047816/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140858804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Discriminatory Ability of Ganglion Cell Inner Plexiform Layer Complex Thickness in Patients with Preperimetric Glaucoma.","authors":"Bhavya Mehta, Somesh Ranjan, Vinod Sharma, Neha Singh, Nidhi Raghav, Acid Dholakia, Rahul Bhargava, P Laxmi Sireesha Reddy, Pooja Bargujar","doi":"10.4103/joco.joco_124_23","DOIUrl":"https://doi.org/10.4103/joco.joco_124_23","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate diagnostic performance of ganglion cell inner plexiform layer (GCIPL) and retinal nerve fiber layer (RNFL) parameters measured with Cirrus high-definition optical coherence tomography (OCT) in patients with preperimetric glaucoma.</p><p><strong>Methods: </strong>In this multicenter cross-sectional study, 150 eyes of 83 patients with preperimetric glaucoma were compared with 200 eyes of age and sex matched healthy subjects. All patients had visual field testing and OCT scanning of GCIPL and RNFL in all quadrants. The independent Samples <i>t</i>-test was used to determine if a difference exists between the means of two independent groups on a continuous dependent variable. The area under the receiver operating characteristic (ROC) curve (AUC) of each parameter was calculated for discriminatory ability between normal controls and preperimetric glaucoma. The sensitivity and specificity were estimated by point coordinates on ROC curve.</p><p><strong>Results: </strong>The best parameters for distinguishing preperimetric glaucoma from healthy eyes were the combined average GCIPL + average RNFL, followed by average RNFL + GCIPL (inferotemporal), and average RNFL + GCIPL (minimum). The GCIPL parameters with the highest to lowest AUC (in decreasing order) were inferotemporal, followed by average, minimum, superior, inferior, superonasal, inferonasal, superotemporal, and quadrants. The RNFL parameters with the highest to lowest AUC (in decreasing order) were average, followed by nasal, temporal, superior, and inferior quadrants. The sensitivity of combined GCIPL + RNFL parameters ranged 85%-88% and the specificity ranged 76%-88%. The sensitivity for RNFL parameters ranged 80%-90% and the specificity ranged 64%-88%.</p><p><strong>Conclusion: </strong>GCIPL and RNFL have good discriminatory ability; the sensitivity and specificity increase when both parameters are combined for early detection of glaucoma.</p>","PeriodicalId":15423,"journal":{"name":"Journal of Current Ophthalmology","volume":"35 3","pages":"231-237"},"PeriodicalIF":1.5,"publicationDate":"2024-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11047817/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140851166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Eyedrop Instillation Techniques, Difficulties, and Currently Available Solutions: A Literature Review.","authors":"Rohan Dadak, Amin Hatamnejad, Nikhil S Patil, Hongbo Qiu, Toby Y B Chan, Jaspreet Rayat","doi":"10.4103/joco.joco_308_22","DOIUrl":"https://doi.org/10.4103/joco.joco_308_22","url":null,"abstract":"<p><strong>Purpose: </strong>To review current eyedrop instillation techniques, common difficulties faced by patients instilling eyedrops, available eyedrop assistive devices, and patient education regarding eyedrop instillation.</p><p><strong>Methods: </strong>PubMed, Embase, and Google Scholar were searched from conception until June 2022 for articles on eyedrop instillation difficulties, techniques, tools, and patient education.</p><p><strong>Results: </strong>Instillation involves pulling down the lower eyelids and placing drops on the corneal surface or conjunctival fornix, followed by closing of the eyelids for about 1 min. Examples of techniques include eyelid closure and nasolacrimal obstruction techniques. Patients encounter many difficulties when administering eyedrops, including but not limited to poor visibility, squeezing the dropper bottle, aiming the bottle, and accidentally blinking. However, devices are available that assist with aim and dropper compression-force reduction in eyedrop instillation. These can be particularly useful in patient demographics with diminished manual dexterity or the ability to generate force from their fingers. Furthermore, despite patient education in eyedrop instillation not being a common practice, it has been found that adequate patient education can lead to significant improvement in eyedrop instillation technique.</p><p><strong>Conclusions: </strong>While many factors are associated with poor eyedrop instillation technique, there are many solutions available including assistive devices and proper instillation education.</p>","PeriodicalId":15423,"journal":{"name":"Journal of Current Ophthalmology","volume":"35 3","pages":"226-230"},"PeriodicalIF":1.5,"publicationDate":"2024-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11047814/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140859299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Postkeratoplasty Corneal Plaques: A Case Series.","authors":"Mohamed Bahgat Badawi Goweida, Mohamed Aly Kolaib, Wael Abdel Rahman El-Menawy, Amr Fathi Abuelkheir, Alaa Atef Ghaith","doi":"10.4103/joco.joco_315_22","DOIUrl":"https://doi.org/10.4103/joco.joco_315_22","url":null,"abstract":"<p><strong>Purpose: </strong>To assess the risk factors and management of corneal plaques formed after keratoplasty.</p><p><strong>Methods: </strong>In this retrospective study, medical records of all eyes with plaques formed on top of corneal grafts performed in the period between January 2014 and January 2022 were reviewed. The retrieved data included prekeratoplasty corneal pathology, ocular risk factors, operative data and complications, plaque management, and chemical composition of the plaques using infrared spectrometer.</p><p><strong>Results: </strong>Thirteen eyes were included in this study. Predisposing ocular comorbidities included ocular surface disorders with variable degrees of dry eye in nine patients, rheumatoid arthritis in three patients, history of herpetic keratitis in two eyes, and cicatrizing conjunctivitis in two patients. Surgical excision and amniotic membrane transplantation (AMT) were performed in 12 eyes. Postoperatively, five eyes showed recurrence after excision, two eyes developed graft vascularization and scarring, and one eye showed persistent epithelial defect and graft scarring, whereas four eyes showed complete epithelialization with mild haze. Rekeratoplasty and AMT were performed in two eyes with no plaque recurrence. Chemical analysis using infrared spectrometry showed that the plaques consisted of ammonium magnesium phosphate and calcium phosphate carbonate in 9 (75%) cases and pure mucus in 3 (25%) cases.</p><p><strong>Conclusions: </strong>Postkeratoplasty corneal plaque formation is an underestimated complication of keratoplasty that may occur after persistent epithelial defects. Ocular surface disorders are the primary predisposing risk factors. In our experience, the prognosis after medical treatment or surgical scraping is guarded, and regrafting can be the only solution to restore graft clarity.</p>","PeriodicalId":15423,"journal":{"name":"Journal of Current Ophthalmology","volume":"35 3","pages":"244-248"},"PeriodicalIF":1.5,"publicationDate":"2024-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11047806/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140855339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}