Journal of Current Ophthalmology最新文献

{"title":"Assessment of MIR200B Polymorphisms Association with Sight-Threatening Diabetic Retinopathy.","authors":"Niloufar Zal, Sare Safi, Hamid Ahmadieh, Sahba Fekri, Sajad Najafi, Ali Forouhari, Afrooz Moghaddasi, Majd Hejazi, Bahareh Kheiri, Maryam Eslami, Fatemeh Suri","doi":"10.4103/joco.joco_287_22","DOIUrl":"https://doi.org/10.4103/joco.joco_287_22","url":null,"abstract":"<p><strong>Purpose: </strong>To assess the possible association between MIR200B variations and sight-threatening diabetic retinopathy (STDR).</p><p><strong>Methods: </strong>A total number of 141 diabetes mellitus patients were enrolled in the study and divided into two groups including 76 patients diagnosed with STDR assigned to the case group, and 65 subjects without STDR considered in the control group. Peripheral blood specimens were used to extract the DNA content, and the primary MIR200B encoding sequence was amplified using a polymerase chain reaction. Then, the amplified DNA was sequenced by the Sanger method. The sequences were compared to the MIR200B reference sequence to find sequence variations. RNAfold, miRVaS, and Mfold bioinformatics web servers were employed to predict the potential effects of the identified variations on RNA structure.</p><p><strong>Results: </strong>Two MIR200B gene variants were identified. Although both variations were found more frequent in cases than controls, statistical analysis of allelic and genotypic features did not reach statistical significance.</p><p><strong>Conclusions: </strong><i>In silico</i> analysis showed mild changes in MIR200B secondary structure and increased free energy in the presence of one of the identified variants (g.1167183G>A; rs72563729). Increasing the sample size in future studies may help a more accurate interpretation of the allelic association of MIR200B variations with STDR.</p>","PeriodicalId":15423,"journal":{"name":"Journal of Current Ophthalmology","volume":"35 4","pages":"355-361"},"PeriodicalIF":1.2,"publicationDate":"2024-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11392297/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142288286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Correlation of Global Burden of Vision Impairment and Ambient Atmospheric Fine Particulate Matter.","authors":"Parya Abdolalizadeh, Khalil Ghasemi Falavarjani","doi":"10.4103/joco.joco_125_23","DOIUrl":"https://doi.org/10.4103/joco.joco_125_23","url":null,"abstract":"<p><strong>Purpose: </strong>To assess the correlation between the worldwide burden of vision impairment (VI) and fine particulate matter (PM) 2.5.</p><p><strong>Methods: </strong>In this retrospective cross-sectional study, global and national prevalence and disability-adjusted lost year (DALY) numbers and rates of total VI, glaucoma, cataract, and age-related macular degeneration (AMD) were obtained from the Global Burden of Disease database. The global and national levels of PM2.5 levels were also extracted. The main outcome measures were the correlation of PM2.5 levels with total VI and three ocular diseases in different age, sex, and socioeconomic subgroups.</p><p><strong>Results: </strong>In 2019, the worldwide prevalence of total VI and exposure level of PM2.5 was 9.6% (95% uncertainty interval: 8.0-11.3) and 42.5 μg/m³, respectively. The national age-standardized prevalence rates of total VI (<i>r</i> _p = 0.52, <i>P</i> < 0.001), glaucoma (<i>r</i> _p = 0.65, <i>P</i> < 0.001), AMD (<i>r</i> _p = 0.67, <i>P</i> < 0.001), and cataract (<i>r</i> _p = 0.44, <i>P</i> < 0.001) have a positive correlation with PM2.5 levels. In addition, the national age-standardized DALY rates of total VI (<i>r</i> _p = 0.62, <i>P</i> < 0.001), glaucoma (<i>r</i> _p = 0.62, <i>P</i> < 0.001), AMD (<i>r</i> _p = 0.54, <i>P</i> < 0.001), and cataract (<i>r</i> _p = 0.45, <i>P</i> < 0.001) significantly correlated with PM2.5 levels. The correlations remained significant in different age, sex, and sociodemographic subgroups.</p><p><strong>Conclusion: </strong>National prevalence rates of VI and three major ocular diseases correlate significantly with PM2.5 exposure levels, worldwide.</p>","PeriodicalId":15423,"journal":{"name":"Journal of Current Ophthalmology","volume":"35 4","pages":"387-394"},"PeriodicalIF":1.2,"publicationDate":"2024-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11392291/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142288293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Peripapillary Retinal Nerve Fiber Layer Thickness Changes in Preterm Children with or without Retinopathy of Prematurity History.","authors":"Siamak Zarei-Ghanavati, Hadi Ostadimoghaddam, Marzieh Najjaran, Nasser Shoeibi, Mohammed Ziaei","doi":"10.4103/joco.joco_159_23","DOIUrl":"https://doi.org/10.4103/joco.joco_159_23","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate peripapillary retinal nerve fiber layer (pRNFL) thickness changes in preterm children with or without retinopathy of prematurity (ROP) history compared to full-term children.</p><p><strong>Methods: </strong>A retrospective comparative cohort study assessing pRNFL thickness was completed in children aged 4-8 years. Four groups of children were included (<i>n</i> = 30 each group): children with a history of ROP who were treated with intravitreal bevacizumab, children with ROP who received no treatment, and preterm children without ROP compared to age- and gender-matched full-term children.</p><p><strong>Results: </strong>A total of 120 eyes from 120 children were enrolled in this study. Both treated and regressed ROP children showed a significantly thinner pRNFL in the nasal quadrant compared to full-term children (<i>P</i> = 0.017 and <i>P</i> = 0.008, respectively). The pRNFL in the superior quadrant of treated ROP children was thinner than the preterm and control groups (<i>P</i> = 0.015 and <i>P</i> = 0.023, respectively), whereas the inferior quadrant of treated ROP children was thinner than the preterm group alone (<i>P</i> = 0.008). The pRNFL thickness in the temporal quadrant was comparable between groups (<i>P</i> = 0.129). The average spatial distribution profile of pRNFL thickness in treated ROP children was significantly thinner than in the preterm group (<i>P</i> = 0.041).</p><p><strong>Conclusion: </strong>pRNFL thickness is significantly altered in children with a prior history of treated ROP with thinning of the nasal and superior quadrants compared to full-term children.</p>","PeriodicalId":15423,"journal":{"name":"Journal of Current Ophthalmology","volume":"35 4","pages":"381-386"},"PeriodicalIF":1.2,"publicationDate":"2024-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11392296/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142288279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Q Fever Endocarditis with Bilateral Multifocal Retinitis: A Case Report.","authors":"Rym Maamouri, Olfa Beizig, Khadija Mzoughi, Monia Cheour","doi":"10.4103/joco.joco_81_23","DOIUrl":"https://doi.org/10.4103/joco.joco_81_23","url":null,"abstract":"<p><strong>Purpose: </strong>To describe a case of bilateral retinitis in a patient with endocarditis and a serologically confirmed Q fever.</p><p><strong>Methods: </strong>A single case report documented with multimodal imaging.</p><p><strong>Results: </strong>A 55-year-old patient with culture-negative endocarditis was referred to our department for an ocular examination. His visual acuity was 20/20 in both eyes. Fundus examination showed white retinal infiltrates with few superficial retinal hemorrhages scattered in the posterior pole. There was no staining on fluorescein angiography. Swept-source optical coherence tomography (SS-OCT) revealed increased inner retinal reflectivity with a focal area of retinal thickening. Laboratory tests showed a high titer of antibodies against <i>Coxiella burnetii</i>. The patient was treated with doxycycline. Two weeks later, fundus examination showed partial resolution of retinitis with inner retinal thinning in SS-OCT.</p><p><strong>Conclusions: </strong>Multifocal retinitis is an uncommon presentation of Q fever. The diagnosis should be considered, especially when associated with culture-negative infective endocarditis, highlighting the importance of routine ocular examination.</p>","PeriodicalId":15423,"journal":{"name":"Journal of Current Ophthalmology","volume":"35 4","pages":"405-407"},"PeriodicalIF":1.2,"publicationDate":"2024-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11392299/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142288281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-Term Surgical Outcomes of Bilateral Symmetrical Superior Oblique Nasal Tenotomy in Patients of Large A-Pattern Exotropia.","authors":"Pramod Kumar Pandey, Anupam Singh, Sreeram Jayaraj, Rupal Verma, Rakesh Panyala, Sanjeev Kumar Mittal, Barun Kumar","doi":"10.4103/joco.joco_175_23","DOIUrl":"https://doi.org/10.4103/joco.joco_175_23","url":null,"abstract":"<p><strong>Purpose: </strong>To report the long-term outcomes of bilateral symmetrical superior oblique (SO) nasal tenotomy in patients with large A-pattern exotropia (≥25 prism diopter [PD]).</p><p><strong>Methods: </strong>This retrospective study was conducted on 15 patients (aged: 4-28 years) of large A-pattern exotropia. An A-pattern was defined as >10 PD difference between up and down gaze at 6 m by use of the alternate prism cover test. Objective ocular torsion was assessed by fundus photography and subjective torsion by double Maddox rod test. All patients underwent horizontal muscle surgery according to the primary position horizontal deviation and bilateral symmetrical SO nasal tenotomy for A-pattern. Surgical success was defined as postoperative A-pattern of ≤10 PD, the absence of vertical and torsional diplopia, and the absence of V-pattern. The minimum follow-up period was 24 months.</p><p><strong>Results: </strong>A total of 15 patients of large A-pattern exotropia (7 males and 8 females) with a mean age of 17.09 ± 7.9 years were included in the study. All patients had bilateral SO overaction of grade +3 or +4 with a mean preoperative A-pattern of 30.3 ± 3.9 PD. At 24 months of follow-up, esotropia in down gaze (V-pattern) was present in four patients with a mean of 11.25 ± 2.5 PD, (range, 10-15 PD). The rest of the 11 patients maintained successful alignment with a mean A-pattern of 3.18 ± 1.17 PD, (range, 2-5 PD). There was significant A-pattern collapse with a mean of 31 ± 9.1 PD after 2 years of follow-up, which was significantly associated with preoperative A-pattern (Pearson correlation, <i>r</i> = 0.7; <i>t</i>[¹⁵] = 4.0; <i>P</i> = 0.002). The mean of pre- and postoperative objective ocular torsion was found to be -0.5 ± 4° and -4.8 ± 3.8° with a mean extorsion effect of 4.67 ± 3.85°. There was a statistically significant difference between pre- and postoperative ocular torsion (°) (<i>t</i> [30] = 5.42; <i>P</i> < 0.001), the change in ocular torsion was significantly associated with preoperative torsion (Pearson correlation, <i>r</i> = 0.5; <i>t</i> [30] = 7.2; <i>P</i> < 0.001). None of the patients had subjective torsion on the double Maddox rod test pre- and postoperatively.</p><p><strong>Conclusions: </strong>Bilateral symmetrical SO nasal tenotomy is effective in cases with large A-pattern (>25 PD). The reduction of A-pattern and postoperative change in fundus torsion have a positive correlation with preoperative A-pattern and preoperative torsion, respectively.</p>","PeriodicalId":15423,"journal":{"name":"Journal of Current Ophthalmology","volume":"35 4","pages":"375-380"},"PeriodicalIF":1.2,"publicationDate":"2024-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11392289/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142288275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Physical Characteristics, Clinical Application, and Side Effects of Viscoelastics in Ophthalmology.","authors":"Mehrdad Mohammadpour, Hassan Asadigandomani, Mehdi Aminizade, Saeed Raeisi","doi":"10.4103/joco.joco_178_23","DOIUrl":"https://doi.org/10.4103/joco.joco_178_23","url":null,"abstract":"<p><strong>Purpose: </strong>To explain the physical properties of ophthalmic viscoelastic devices (OVDs), covering their structural units, optimal features, existing viscoelastic materials, clinical applications, and potential side effects.</p><p><strong>Methods: </strong>This is a narrative review on the OVDs. A literature review was conducted in PubMed, Google Scholar, and Scopus databases. Studies that investigated physical characteristics, clinical applications, OVD commercial products, and their complications were included.</p><p><strong>Results: </strong>We included 42 articles from 2010 and discussed physical characteristics, properties of a desirable OVD, structural units of common OVDs, OVD commercial products, clinical applications, and also complications of OVDs.</p><p><strong>Conclusions: </strong>Today, viscoelastics hold a distinct and crucial role in intraocular surgery due to their remarkable properties. These materials safeguard the endothelium and epithelium, uphold anterior chamber depth, manage intraocular bleeding, ease tissue handling, and aid intraocular lens placement. Currently, the American market features 12 prevalent viscoelastic types, including 7 sodium hyaluronate derivatives (Healon, Healon-Greater Viscosity, Healon-5, Amvisc, Amvisc Plus, Advanced Medical Optics Vitrax, and Provisc), 2 hydroxypropyl methylcellulose 2% derivatives (OcuCoat and Cellugel), and 3 combinations of sodium hyaluronate and chondroitin sulfate (Viscoat, DisCoVisc, and DuoVisc). Despite the introduction of new viscoelastic materials annually, no single material encompasses all desired properties. Surgeons must select and employ suitable viscoelastics based on surgical conditions and patient requirements. Advancements in material development and understanding of physical properties and clinical applications continue to refine viscoelastic selection.</p>","PeriodicalId":15423,"journal":{"name":"Journal of Current Ophthalmology","volume":"35 4","pages":"313-319"},"PeriodicalIF":1.2,"publicationDate":"2024-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11392293/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142288280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Choroidal Features of Healthy Iranian Individuals.","authors":"Ali Banafsheafshan, Haniyeh Zeidabadinejad, Masoud Mirghorbani, Hooshang Faghihi, Elias Khalili Pour, Hamid Riazi-Esfahani","doi":"10.4103/joco.joco_116_23","DOIUrl":"https://doi.org/10.4103/joco.joco_116_23","url":null,"abstract":"<p><strong>Purpose: </strong>To assess subfoveal choroidal thickness (SFCT) and choroidal vascularity index (CVI) profile in the Iranian healthy population and assessment of the inter-eye difference in this regard.</p><p><strong>Methods: </strong>In a cross-sectional study, 141 healthy subjects underwent an assessment of refraction and best-corrected visual acuity (BCVA), axial length (AL), and measurement of the intraocular pressure. The imaging of the choroid was performed using the enhanced-depth imaging mode of Spectralis optical coherence tomography from the foveal slab to measure SFCT and calculate CVI.</p><p><strong>Results: </strong>A total of 282 eyes of 141 healthy subjects (59.6% men, mean age of 60.86 ± 11.46 years) enrolled in the current study. The mean SFCT of the right and left eye was 247.40 ± 70.37 and 251.25 ± 72.19, respectively. The mean CVI of the right and left eye was 62.63 ± 3.77 and 63.19 ± 3.91, respectively. None of the measured parameters had statistically significant differences between the left and right eyes. In both univariate and multivariate regression analysis, CVI was significantly associated with BCVA (<i>P</i> < 0.001) but was not associated with age, spherical equivalent (SE), gender, central macular thickness (CMT), and SFCT. In univariate regression analysis, SFCT was significantly associated with age, refraction (<i>P</i> = 0.02), BCVA (<i>P</i> = 0.003), AL (<i>P</i> < 0.001), and CVI (<i>P</i> = 0.02) but not significantly associated with gender and CMT. In multivariate analysis, age (<i>P</i> < 0.001), gender (<i>P</i> = 0.001), and AL (<i>P</i> < 0.001) were significantly associated with SFCT, but SE, BCVA, CVI, and CMT were not significantly associated.</p><p><strong>Conclusions: </strong>This was the first investigation to assess the SFCT and CVI simultaneously in the Iranian population to establish a normative database for future studies. CVI was less variable than SFCT in a healthy population, and no statistically significant differences existed between the left and right eyes.</p>","PeriodicalId":15423,"journal":{"name":"Journal of Current Ophthalmology","volume":"35 4","pages":"369-374"},"PeriodicalIF":1.2,"publicationDate":"2024-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11392307/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142288287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinicopathological Features and Management of Orbital Cholesterol Granuloma.","authors":"Yun Zhao, Jiagen Li, Zhongkun Ji, Shasha Yu, Jinyong Lin, Hong Zhao","doi":"10.4103/joco.joco_200_23","DOIUrl":"https://doi.org/10.4103/joco.joco_200_23","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the clinical features, radiographic features, treatment strategies, pathological features, and prognosis of orbital cholesterol granuloma (CG).</p><p><strong>Methods: </strong>Twelve patients with orbital CG who were referred to Tianjin Eye Hospital between January 2002 and December 2020 were included in this retrospective case series study. Data collected including patient ophthalmic manifestations, imaging findings, treatment strategies, pathological features, and prognosis were retrospectively reviewed.</p><p><strong>Results: </strong>The patients comprised 10 males and 2 females. The mean age was 34.5 years (standard deviation [SD] = 8.9, median: 36 and range: 16-45 years). Four patients had a history of orbital trauma. The clinical manifestations at the first visit were proptosis (7/12, 58.3%), periorbital or eyelid swelling (6/12, 50%), limitation of eye movement (4/12, 33.3%), ptosis (2/12, 16.7%), and decreased visual acuity (1/12, 8.3%). Computed tomography (CT) showed a nonenhancing, well-circumscribed lesion in the orbit with extensive erosion of the adjacent frontal bone and temporal bone. Magnetic resonance imaging (MRI) showed a nonenhancing mass with intermediate-to-high signal intensity on T1- and T2-weighted images. Ten patients underwent lateral orbitotomy, and two patients underwent supraorbital orbitotomy. All patients had aggressive bone erosion. Histopathologic evaluation of the cyst contents and wall revealed cholesterol clefts, multinucleated giant cells, histiocytes, foamy macrophages, and altered blood pigments. The mean follow-up time of 79.6 months (SD = 49.8, range: 19-193 months). Three patients were lost to follow-up. No postoperative diminution of vision was noted, and no recurrence was observed.</p><p><strong>Conclusions: </strong>CGs can present as superotemporal or temporal orbital lesions. The diagnosis can be established based on CT and MRI. Most of the patients can have no history of orbital trauma.</p>","PeriodicalId":15423,"journal":{"name":"Journal of Current Ophthalmology","volume":"35 4","pages":"401-404"},"PeriodicalIF":1.2,"publicationDate":"2024-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11392298/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142288289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum: Corneal Ectasia after Laser-Assisted Small-Incision Lenticule Extraction: The Case for an Enhanced Ectasia Risk Assessment.","authors":"","doi":"10.4103/joco.joco_43_24","DOIUrl":"https://doi.org/10.4103/joco.joco_43_24","url":null,"abstract":"<p><p>[This corrects the article on p. 357 in vol. 34, PMID: 36644473.].</p>","PeriodicalId":15423,"journal":{"name":"Journal of Current Ophthalmology","volume":"35 4","pages":"417"},"PeriodicalIF":1.2,"publicationDate":"2024-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11392301/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142288292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison between the Efficacy and Tolerability of Polyvinylpyrrolidone-Iodine Eye Drops 0.6% and 1% in Adenoviral Keratoconjunctivitis: A Randomized Clinical Trial.","authors":"Ali Makateb, Mahdi Soleymanzadeh, Saeed Soleiman-Meigooni, Ali Asgari, Mohammad Reza Etemadi, Amir Reza Mafi, Nader Mohammadi","doi":"10.4103/joco.joco_251_23","DOIUrl":"https://doi.org/10.4103/joco.joco_251_23","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the effect of topical Polyvinylpyrrolidone-iodine (PVP-I) 0.6% on the clinical course of adenoviral keratoconjunctivitis compared with PVP-I 1% and artificial tears.</p><p><strong>Methods: </strong>We prospectively enrolled all patients over 18 years of age with a polymerase chain reaction (PCR)-confirmed diagnosis of adenoviral keratoconjunctivitis who presented to the hospital between November 2022 and June 2023. Patients were randomized into 3 groups: artificial tears (control), PVP-I 1%, and PVP-I 0.6% eye drops, 4 times daily for 5 days. Clinical signs at presentation and at 6 follow-up visits during the 1^st 3 weeks of the acute phase were recorded. Patients were also followed up at 1 and 3 months.</p><p><strong>Results: </strong>Ninety-four patients completed the study, of which 30, 31, and 33 were in the control, PVP-I 1%, and PVP-I 0.6% groups, respectively. The mean age of the patients was 37.2 years (interquartile range: 25-46). The PCR result was positive in 75.6% of patients with the clinical suspicion. PVP-I, regardless of the concentration, was superior to the artificial tears in terms of time to resolution of lid swelling, discharge, and incidence of subsequent subepithelial infiltrates (<i>P</i> < 0.05). However, a concentration of 0.6% was equivalent to 1%. No significant adverse events were reported in any group.</p><p><strong>Conclusions: </strong>The PVP-I 0.6% topical drops are safe and well tolerated in patients with acute adenoviral keratoconjunctivitis. It can be substituted for the 1% solution as it has comparable effects in improving the clinical course and reducing subsequent complications.</p>","PeriodicalId":15423,"journal":{"name":"Journal of Current Ophthalmology","volume":"35 4","pages":"337-344"},"PeriodicalIF":1.2,"publicationDate":"2024-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11392302/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142288290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}